locus-tag	class	description
A6J80_RS00010	COG3473	Maleate cis-trans isomerase
A6J80_RS00015	COG0596	Alpha beta hydrolase
A6J80_RS00020	COG2309	aminopeptidase activity
A6J80_RS00025	COG1335	isochorismatase
A6J80_RS00030	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A6J80_RS00040	COG3284	Transcriptional regulator
A6J80_RS00045	COG0145	ligase activity
A6J80_RS00050	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
A6J80_RS00055	COG4647	ligase activity
A6J80_RS00065	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A6J80_RS00080	COG1122	ATPase activity
A6J80_RS00085	COG1122	ATPase activity
A6J80_RS00145	COG3547	Transposase (IS116 IS110 IS902 family)
A6J80_RS00155	COG3547	Transposase (IS116 IS110 IS902 family)
A6J80_RS00165	COG3547	Transposase (IS116 IS110 IS902 family)
A6J80_RS00185	COG0747	negative chemotaxis
A6J80_RS00190	COG0601	transmembrane transport
A6J80_RS00195	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A6J80_RS00200	COG4172	Belongs to the ABC transporter superfamily
A6J80_RS00205	COG4608	Belongs to the ABC transporter superfamily
A6J80_RS00210	COG0830	nickel cation binding
A6J80_RS00215	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
A6J80_RS00220	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
A6J80_RS00225	COG0829	nickel cation binding
A6J80_RS00230	COG0831	urea catabolic process
A6J80_RS00235	COG0832	Belongs to the urease beta subunit family
A6J80_RS00240	COG0804	urea catabolic process
A6J80_RS00290	COG1797	cobyrinic acid a,c-diamide synthase activity
A6J80_RS00295	COG2875	Belongs to the precorrin methyltransferase family
A6J80_RS00310	COG2099	Precorrin-6x reductase
A6J80_RS00360	COG1120	ATPase activity
A6J80_RS00365	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6J80_RS00385	COG3842	ATPase activity
A6J80_RS00390	COG3842	ATPase activity
A6J80_RS00400	COG0395	ABC-type sugar transport system, permease component
A6J80_RS00425	COG0670	Belongs to the BI1 family
A6J80_RS00455	COG0559	Belongs to the binding-protein-dependent transport system permease family
A6J80_RS00465	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
A6J80_RS00470	COG0129	dihydroxy-acid dehydratase activity
A6J80_RS00475	COG0583	DNA-binding transcription factor activity
A6J80_RS00480	COG1116	anion transmembrane transporter activity
A6J80_RS00485	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A6J80_RS00490	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A6J80_RS00495	COG0431	NADPH-dependent FMN reductase
A6J80_RS00505	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A6J80_RS00520	COG3246	L-lysine catabolic process to acetate
A6J80_RS00525	COG3485	protocatechuate 3,4-dioxygenase
A6J80_RS00530	COG3485	protocatechuate 3,4-dioxygenase
A6J80_RS00540	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A6J80_RS00550	COG2814	Major facilitator Superfamily
A6J80_RS00570	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
A6J80_RS00575	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
A6J80_RS00580	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A6J80_RS00590	COG1192	Involved in chromosome partitioning
A6J80_RS00595	COG1475	DNA binding
A6J80_RS00600	COG1940	carbohydrate kinase activity
A6J80_RS00605	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A6J80_RS00610	COG0523	cobalamin synthesis protein
A6J80_RS00615	COG2951	lytic endotransglycosylase activity
A6J80_RS00620	COG1607	acyl-coa hydrolase
A6J80_RS00625	COG1823	symporter activity
A6J80_RS00640	COG0477	Major facilitator Superfamily
A6J80_RS00645	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A6J80_RS00650	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A6J80_RS00655	COG1845	cytochrome c oxidase, subunit III
A6J80_RS00660	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
A6J80_RS00670	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
A6J80_RS00700	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A6J80_RS00715	COG1960	acyl-CoA dehydrogenase activity
A6J80_RS00720	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
A6J80_RS00745	COG2186	Transcriptional regulator
A6J80_RS00750	COG1172	Belongs to the binding-protein-dependent transport system permease family
A6J80_RS00755	COG1172	Belongs to the binding-protein-dependent transport system permease family
A6J80_RS00760	COG1129	ABC transporter
A6J80_RS00765	COG1879	ABC-type sugar transport system periplasmic component
A6J80_RS00795	COG1132	(ABC) transporter
A6J80_RS00835	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
A6J80_RS00840	COG1301	dicarboxylic acid transport
A6J80_RS00845	COG0583	DNA-binding transcription factor activity
A6J80_RS00865	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A6J80_RS00870	COG0243	molybdopterin cofactor binding
A6J80_RS00875	COG2116	formate transmembrane transporter activity
A6J80_RS00880	COG2146	nitrite reductase [NAD(P)H] activity
A6J80_RS00885	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A6J80_RS00895	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A6J80_RS00895	COG1116	anion transmembrane transporter activity
A6J80_RS00900	COG3707	response regulator
A6J80_RS00905	COG0392	lysyltransferase activity
A6J80_RS00905	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
A6J80_RS00910	COG0517	IMP dehydrogenase activity
A6J80_RS00910	COG0617	tRNA 3'-terminal CCA addition
A6J80_RS00910	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
A6J80_RS00915	COG2197	response regulator
A6J80_RS00925	COG1879	ABC-type sugar transport system periplasmic component
A6J80_RS00930	COG1129	ABC transporter
A6J80_RS00935	COG1172	Belongs to the binding-protein-dependent transport system permease family
A6J80_RS00940	COG1172	Belongs to the binding-protein-dependent transport system permease family
A6J80_RS00960	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
A6J80_RS00965	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
A6J80_RS00985	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A6J80_RS01000	COG2855	membrane
A6J80_RS01005	COG0028	Belongs to the TPP enzyme family
A6J80_RS01020	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A6J80_RS01025	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
A6J80_RS01030	COG4521	taurine ABC transporter
A6J80_RS01040	COG0667	Aldo Keto reductase
A6J80_RS01050	COG0402	S-adenosylhomocysteine deaminase activity
A6J80_RS01055	COG2233	PERMEase
A6J80_RS01060	COG1609	Transcriptional regulator
A6J80_RS01080	COG1116	anion transmembrane transporter activity
A6J80_RS01090	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A6J80_RS01105	COG1172	Belongs to the binding-protein-dependent transport system permease family
A6J80_RS01120	COG1028	Short-chain dehydrogenase reductase Sdr
A6J80_RS01145	COG0438	transferase activity, transferring glycosyl groups
A6J80_RS01160	COG1192	Involved in chromosome partitioning
A6J80_RS01180	COG0183	Belongs to the thiolase family
A6J80_RS01190	COG1268	BioY protein
A6J80_RS01195	COG1609	Transcriptional regulator
A6J80_RS01205	COG0673	inositol 2-dehydrogenase activity
A6J80_RS01210	COG1129	ABC transporter
A6J80_RS01215	COG1172	Belongs to the binding-protein-dependent transport system permease family
A6J80_RS01220	COG1879	ABC-type sugar transport system periplasmic component
A6J80_RS01270	COG1120	ATPase activity
A6J80_RS01275	COG1132	(ABC) transporter
A6J80_RS01285	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
A6J80_RS01305	COG1216	Glycosyl transferase, family 2
A6J80_RS01305	COG0438	transferase activity, transferring glycosyl groups
A6J80_RS01310	COG1522	sequence-specific DNA binding
A6J80_RS01320	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
A6J80_RS01330	COG1045	serine acetyltransferase
A6J80_RS01365	COG2323	membrane
A6J80_RS01380	COG2894	cell division
A6J80_RS01385	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
A6J80_RS01395	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
A6J80_RS01405	COG3547	Transposase (IS116 IS110 IS902 family)
A6J80_RS01430	COG4303	Ethanolamine ammonia lyase large subunit
A6J80_RS01445	COG1349	DNA-binding transcription factor activity
A6J80_RS01450	COG1454	alcohol dehydrogenase
A6J80_RS01465	COG0196	riboflavin kinase activity
A6J80_RS01480	COG1176	ABC-type spermidine putrescine transport system, permease component I
A6J80_RS01485	COG4993	Dehydrogenase
A6J80_RS01500	COG0277	FAD linked oxidase domain protein
A6J80_RS01505	COG1012	belongs to the aldehyde dehydrogenase family
A6J80_RS01515	COG3547	Transposase (IS116 IS110 IS902 family)
A6J80_RS01540	COG0004	ammonium transporteR
A6J80_RS01545	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A6J80_RS01550	COG2218	PFAM glutamate synthase alpha subunit domain protein
A6J80_RS01555	COG0069	glutamate synthase activity
A6J80_RS01560	COG0174	glutamine synthetase
A6J80_RS01565	COG2186	Transcriptional regulator
A6J80_RS01580	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A6J80_RS01590	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A6J80_RS01610	COG4977	sequence-specific DNA binding
A6J80_RS01615	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A6J80_RS01620	COG4311	Sarcosine oxidase, delta subunit
A6J80_RS01625	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A6J80_RS01625	COG0446	pyridine nucleotide-disulphide oxidoreductase
A6J80_RS01635	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A6J80_RS01675	COG0277	FAD linked oxidase domain protein
A6J80_RS01765	COG1132	(ABC) transporter
A6J80_RS01775	COG1012	belongs to the aldehyde dehydrogenase family
A6J80_RS01820	COG0861	Integral membrane protein TerC family
A6J80_RS01830	COG4993	Dehydrogenase
A6J80_RS01850	COG2010	Cytochrome c
A6J80_RS01850	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A6J80_RS01860	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
A6J80_RS01870	COG1028	Short-chain dehydrogenase reductase Sdr
A6J80_RS01875	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
A6J80_RS01880	COG1917	Cupin 2, conserved barrel domain protein
A6J80_RS01895	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A6J80_RS01900	COG1904	glucuronate isomerase
A6J80_RS01910	COG2169	Transcriptional regulator
A6J80_RS01910	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A6J80_RS01915	COG1414	Transcriptional regulator
A6J80_RS01920	COG0628	permease
A6J80_RS01930	COG1960	acyl-CoA dehydrogenase activity
A6J80_RS01935	COG0583	DNA-binding transcription factor activity
A6J80_RS01945	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A6J80_RS01950	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6J80_RS01960	COG2186	Transcriptional regulator
A6J80_RS01995	COG1172	Belongs to the binding-protein-dependent transport system permease family
A6J80_RS02000	COG1879	ABC-type sugar transport system periplasmic component
A6J80_RS02015	COG1028	Short-chain dehydrogenase reductase Sdr
A6J80_RS02055	COG0579	oxidoreductase
A6J80_RS02075	COG4948	Mandelate Racemase Muconate Lactonizing
A6J80_RS02080	COG0006	proline dipeptidase activity
A6J80_RS02090	COG0583	DNA-binding transcription factor activity
A6J80_RS02105	COG2176	DNA-directed DNA polymerase activity
A6J80_RS02105	COG5002	protein histidine kinase activity
A6J80_RS02110	COG0745	RESPONSE REGULATOR receiver
A6J80_RS02115	COG0517	IMP dehydrogenase activity
A6J80_RS02115	COG0516	GMP reductase activity
A6J80_RS02125	COG3162	membrane
A6J80_RS02130	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A6J80_RS02140	COG0826	peptidase U32
A6J80_RS02150	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
A6J80_RS02160	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A6J80_RS02175	COG0235	Class ii aldolase
A6J80_RS02180	COG3395	kinase activity
A6J80_RS02190	COG1414	Transcriptional regulator
A6J80_RS02200	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
A6J80_RS02205	COG0183	Belongs to the thiolase family
A6J80_RS02215	COG0252	asparaginase activity
A6J80_RS02235	COG1858	cytochrome C peroxidase
A6J80_RS02240	COG0753	catalase activity
A6J80_RS02265	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
A6J80_RS02275	COG0438	transferase activity, transferring glycosyl groups
A6J80_RS02300	COG2267	carboxylic ester hydrolase activity
A6J80_RS02305	COG1573	uracil-dna glycosylase
A6J80_RS02320	COG3718	enzyme involved in inositol metabolism
A6J80_RS02330	COG3962	Belongs to the TPP enzyme family
A6J80_RS02350	COG0673	inositol 2-dehydrogenase activity
A6J80_RS02355	COG1082	Xylose isomerase domain protein TIM barrel
A6J80_RS02365	COG4211	Belongs to the binding-protein-dependent transport system permease family
A6J80_RS02370	COG1129	ABC transporter
A6J80_RS02390	COG0583	DNA-binding transcription factor activity
A6J80_RS02400	COG4774	siderophore transport
A6J80_RS02405	COG4592	Periplasmic binding protein
A6J80_RS02410	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6J80_RS02415	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6J80_RS02420	COG1120	ATPase activity
A6J80_RS02425	COG1028	Short-chain dehydrogenase reductase Sdr
A6J80_RS02440	COG4172	Belongs to the ABC transporter superfamily
A6J80_RS02445	COG4239	(ABC) transporter, permease
A6J80_RS02450	COG4174	ABC transporter (Permease)
A6J80_RS02455	COG4166	transmembrane transport
A6J80_RS02470	COG0433	COG0433 Predicted ATPase
A6J80_RS02490	COG0133	tryptophan synthase activity
A6J80_RS02495	COG0135	phosphoribosylanthranilate isomerase activity
A6J80_RS02505	COG0776	regulation of translation
A6J80_RS02510	COG0539	negative regulation of cytoplasmic translation
A6J80_RS02525	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A6J80_RS02530	COG0052	Belongs to the universal ribosomal protein uS2 family
A6J80_RS02545	COG0477	Major facilitator Superfamily
A6J80_RS02550	COG0534	Mate efflux family protein
A6J80_RS02555	COG0443	Heat shock 70 kDa protein
A6J80_RS02565	COG0628	permease
A6J80_RS02590	COG0330	HflC and HflK could
A6J80_RS02595	COG0330	HflC and HflK could
A6J80_RS02605	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
A6J80_RS02610	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
A6J80_RS02610	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
A6J80_RS02620	COG1546	Belongs to the CinA family
A6J80_RS02620	COG1058	Belongs to the CinA family
A6J80_RS02630	COG2983	Belongs to the UPF0260 family
A6J80_RS02635	COG0196	riboflavin kinase activity
A6J80_RS02640	COG2030	dehydratase
A6J80_RS02680	COG0459	protein refolding
A6J80_RS02690	COG3845	ABC transporter
A6J80_RS02695	COG4603	Belongs to the binding-protein-dependent transport system permease family
A6J80_RS02710	COG0783	Belongs to the Dps family
A6J80_RS02715	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A6J80_RS02725	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A6J80_RS02735	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6J80_RS02785	COG0587	DNA-directed DNA polymerase activity
A6J80_RS02795	COG1268	BioY protein
A6J80_RS02800	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A6J80_RS02855	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A6J80_RS02895	COG3118	belongs to the thioredoxin family
A6J80_RS02935	COG0542	response to heat
A6J80_RS02955	COG0071	Belongs to the small heat shock protein (HSP20) family
A6J80_RS02960	COG0071	Belongs to the small heat shock protein (HSP20) family
A6J80_RS02995	COG2186	Transcriptional regulator
A6J80_RS03000	COG0477	Major facilitator Superfamily
A6J80_RS03010	COG0583	DNA-binding transcription factor activity
A6J80_RS03045	COG0583	DNA-binding transcription factor activity
A6J80_RS03100	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A6J80_RS03105	COG3237	CsbD-like
A6J80_RS03110	COG0189	ligase activity
A6J80_RS03120	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A6J80_RS03130	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
A6J80_RS03135	COG0728	peptidoglycan biosynthetic process
A6J80_RS03145	COG0180	Tryptophanyl-tRNA synthetase
A6J80_RS03150	COG0646	methionine synthase
A6J80_RS03150	COG1410	methionine synthase
A6J80_RS03175	COG0737	Belongs to the 5'-nucleotidase family
A6J80_RS03180	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A6J80_RS03185	COG0740	serine-type endopeptidase activity
A6J80_RS03190	COG0193	aminoacyl-tRNA hydrolase activity
A6J80_RS03200	COG4974	Belongs to the 'phage' integrase family
A6J80_RS03205	COG2442	InterPro IPR007367
A6J80_RS03210	COG4634	DNA integration
A6J80_RS03225	COG2433	Pfam Transposase IS66
A6J80_RS03235	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A6J80_RS03255	COG2814	Major facilitator Superfamily
A6J80_RS03260	COG1937	Protein conserved in bacteria
A6J80_RS03270	COG4227	nucleotidyltransferase activity
A6J80_RS03285	COG1475	DNA binding
A6J80_RS03395	COG1192	Involved in chromosome partitioning
A6J80_RS03425	COG0741	lytic transglycosylase activity
A6J80_RS03445	COG0259	pyridoxamine-phosphate oxidase activity
A6J80_RS03455	COG1028	Short-chain dehydrogenase reductase Sdr
A6J80_RS03460	COG0583	DNA-binding transcription factor activity
A6J80_RS03465	COG4962	Type ii secretion system protein e
A6J80_RS03480	COG3451	type IV secretory pathway VirB4
A6J80_RS03495	COG3846	protein secretion by the type IV secretion system
A6J80_RS03510	COG2948	multi-organism process
A6J80_RS03520	COG0583	DNA-binding transcription factor activity
A6J80_RS03530	COG1230	cation diffusion facilitator family transporter
A6J80_RS03535	COG0640	Transcriptional regulator
A6J80_RS03550	COG0678	peroxiredoxin activity
A6J80_RS03550	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A6J80_RS03555	COG1937	Protein conserved in bacteria
A6J80_RS03560	COG2814	Major facilitator Superfamily
A6J80_RS03565	COG0789	Transcriptional regulator
A6J80_RS03585	COG2132	Multicopper oxidase
A6J80_RS03600	COG0640	Transcriptional regulator
A6J80_RS03605	COG2217	Heavy metal translocating P-type atpase
A6J80_RS03610	COG0789	Transcriptional regulator
A6J80_RS03640	COG0719	Fe-S assembly protein
A6J80_RS03645	COG0396	ATPase activity
A6J80_RS03650	COG0393	Putative heavy-metal-binding
A6J80_RS03655	COG0719	Fe-S assembly protein
A6J80_RS03660	COG1104	cysteine desulfurase activity
A6J80_RS03665	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A6J80_RS03720	COG0803	Belongs to the bacterial solute-binding protein 9 family
A6J80_RS03725	COG1121	(ABC) transporter
A6J80_RS03730	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A6J80_RS03735	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A6J80_RS03740	COG0754	glutathionylspermidine amidase activity
A6J80_RS03745	COG5463	Belongs to the UPF0441 family
A6J80_RS03750	COG0800	Aldolase
A6J80_RS03755	COG2814	Major facilitator Superfamily
A6J80_RS03765	COG1570	exodeoxyribonuclease VII activity
A6J80_RS03770	COG0151	Belongs to the GarS family
A6J80_RS03775	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A6J80_RS03795	COG0768	penicillin binding
A6J80_RS03800	COG0772	Belongs to the SEDS family
A6J80_RS03815	COG1309	transcriptional regulator
A6J80_RS03830	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
A6J80_RS03835	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A6J80_RS03840	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A6J80_RS03860	COG3034	peptidoglycan biosynthetic process
A6J80_RS03870	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
A6J80_RS03885	COG0360	Binds together with S18 to 16S ribosomal RNA
A6J80_RS03890	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A6J80_RS03895	COG0359	binds to the 23S rRNA
A6J80_RS03910	COG2186	Transcriptional regulator
A6J80_RS03915	COG1304	FMN binding
A6J80_RS03920	COG1028	Short-chain dehydrogenase reductase Sdr
A6J80_RS03925	COG1509	lysine 2,3-aminomutase activity
A6J80_RS03930	COG4608	Belongs to the ABC transporter superfamily
A6J80_RS03935	COG0444	Belongs to the ABC transporter superfamily
A6J80_RS03940	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A6J80_RS03945	COG0601	transmembrane transport
A6J80_RS03950	COG0747	negative chemotaxis
A6J80_RS03960	COG2313	pseudouridylate synthase activity
A6J80_RS03970	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A6J80_RS03975	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
A6J80_RS03985	COG0436	Aminotransferase
A6J80_RS03995	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
A6J80_RS04005	COG0156	8-amino-7-oxononanoate synthase activity
A6J80_RS04030	COG0519	Catalyzes the synthesis of GMP from XMP
A6J80_RS04035	COG0174	glutamine synthetase
A6J80_RS04040	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A6J80_RS04045	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A6J80_RS04050	COG1758	RNA polymerase activity
A6J80_RS04055	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A6J80_RS04055	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A6J80_RS04100	COG0765	amino acid transport
A6J80_RS04115	COG0071	Belongs to the small heat shock protein (HSP20) family
A6J80_RS04120	COG0071	Belongs to the small heat shock protein (HSP20) family
A6J80_RS04150	COG0375	protein maturation
A6J80_RS04210	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
A6J80_RS04250	COG0842	Transport permease protein
A6J80_RS04255	COG0842	Transport permease protein
A6J80_RS04255	COG1129	ABC transporter
A6J80_RS04260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6J80_RS04265	COG3712	iron ion homeostasis
A6J80_RS04275	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6J80_RS04280	COG0577	efflux transmembrane transporter activity
A6J80_RS04280	COG1136	(ABC) transporter
A6J80_RS04300	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A6J80_RS04305	COG0372	Belongs to the citrate synthase family
A6J80_RS04310	COG4221	oxidoreductase activity
A6J80_RS04315	COG1492	cobalamin metabolic process
A6J80_RS04325	COG0504	CTP synthase activity
A6J80_RS04365	COG0174	glutamine synthetase
A6J80_RS04380	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
A6J80_RS04380	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A6J80_RS04395	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A6J80_RS04410	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
A6J80_RS04415	COG3437	response regulator, receiver
A6J80_RS04420	COG5002	protein histidine kinase activity
A6J80_RS04420	COG2198	Histidine kinase
A6J80_RS04420	COG0784	Response regulator, receiver
A6J80_RS04430	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
A6J80_RS04435	COG2080	2 iron, 2 sulfur cluster binding
A6J80_RS04440	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
A6J80_RS04445	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A6J80_RS04450	COG1028	Short-chain dehydrogenase reductase Sdr
A6J80_RS04475	COG0418	dihydroorotase activity
A6J80_RS04485	COG0305	Participates in initiation and elongation during chromosome replication
A6J80_RS04495	COG2814	Major facilitator Superfamily
A6J80_RS04500	COG1396	sequence-specific DNA binding
A6J80_RS04500	COG3800	Transcriptional regulator
A6J80_RS04505	COG0739	heme binding
A6J80_RS04515	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A6J80_RS04520	COG0517	IMP dehydrogenase activity
A6J80_RS04520	COG0516	GMP reductase activity
A6J80_RS04535	COG1953	Uracil, thiamine, allantoin
A6J80_RS04540	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
A6J80_RS04555	COG0497	DNA recombination
A6J80_RS04560	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A6J80_RS04570	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A6J80_RS04575	COG0849	cell division
A6J80_RS04580	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
A6J80_RS04585	COG1181	Belongs to the D-alanine--D-alanine ligase family
A6J80_RS04590	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A6J80_RS04600	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A6J80_RS04605	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A6J80_RS04625	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
A6J80_RS04630	COG2326	polyphosphate kinase activity
A6J80_RS04645	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
A6J80_RS04675	COG3273	potassium ion transport
A6J80_RS04675	COG0471	metal ion transport
A6J80_RS04680	COG1692	metallophosphoesterase
A6J80_RS04690	COG2226	methyltransferase
A6J80_RS04695	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A6J80_RS04705	COG0268	Binds directly to 16S ribosomal RNA
A6J80_RS04720	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A6J80_RS04730	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
A6J80_RS04735	COG1381	Involved in DNA repair and RecF pathway recombination
A6J80_RS04755	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A6J80_RS04795	COG1660	Displays ATPase and GTPase activities
A6J80_RS04805	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
A6J80_RS04810	COG0557	exoribonuclease II activity
A6J80_RS04820	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
A6J80_RS04825	COG3383	formate dehydrogenase (NAD+) activity
A6J80_RS04845	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A6J80_RS04880	COG1960	acyl-CoA dehydrogenase activity
A6J80_RS04890	COG0183	Belongs to the thiolase family
A6J80_RS04900	COG1024	Enoyl-CoA hydratase
A6J80_RS04900	COG1250	3-hydroxyacyl-CoA dehydrogenase
A6J80_RS04905	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A6J80_RS04910	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A6J80_RS04915	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A6J80_RS04920	COG2885	chlorophyll binding
A6J80_RS04925	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A6J80_RS04940	COG0356	it plays a direct role in the translocation of protons across the membrane
A6J80_RS04955	COG0737	Belongs to the 5'-nucleotidase family
A6J80_RS04970	COG1045	serine acetyltransferase
A6J80_RS05050	COG4695	Portal protein
A6J80_RS05065	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A6J80_RS05070	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A6J80_RS05075	COG3853	Toxic anion resistance protein (TelA)
A6J80_RS05085	COG4260	virion core protein, lumpy skin disease virus
A6J80_RS05100	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A6J80_RS05105	COG1923	regulation of RNA biosynthetic process
A6J80_RS05110	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A6J80_RS05115	COG0569	domain protein
A6J80_RS05120	COG2204	response regulator
A6J80_RS05125	COG5000	phosphorelay sensor kinase activity
A6J80_RS05130	COG2204	response regulator
A6J80_RS05135	COG3852	Histidine kinase
A6J80_RS05140	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A6J80_RS05145	COG1760	l-serine dehydratase
A6J80_RS05155	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A6J80_RS05170	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A6J80_RS05175	COG1121	(ABC) transporter
A6J80_RS05185	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
A6J80_RS05195	COG1187	pseudouridine synthase activity
A6J80_RS05200	COG0590	tRNA wobble adenosine to inosine editing
A6J80_RS05205	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
A6J80_RS05210	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6J80_RS05215	COG1136	(ABC) transporter
A6J80_RS05215	COG0577	efflux transmembrane transporter activity
A6J80_RS05220	COG0435	Glutathione S-transferase
A6J80_RS05225	COG0672	)-iron permease
A6J80_RS05230	COG2822	iron ion transport
A6J80_RS05240	COG2822	iron ion transport
A6J80_RS05245	COG0105	UTP biosynthetic process
A6J80_RS05250	COG0488	(ABC) transporter
A6J80_RS05260	COG2151	metal-sulfur cluster biosynthetic enzyme
A6J80_RS05265	COG0110	maltose O-acetyltransferase activity
A6J80_RS05270	COG0406	alpha-ribazole phosphatase activity
A6J80_RS05275	COG0408	coproporphyrinogen oxidase activity
A6J80_RS05285	COG1028	Short-chain dehydrogenase reductase Sdr
A6J80_RS05290	COG2813	Specifically methylates the guanine in position
A6J80_RS05295	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
A6J80_RS05300	COG1686	Belongs to the peptidase S11 family
A6J80_RS05320	COG0348	domain, Protein
A6J80_RS05325	COG2010	Cytochrome c
A6J80_RS05350	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A6J80_RS05355	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A6J80_RS05360	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6J80_RS05360	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6J80_RS05370	COG1131	(ABC) transporter
A6J80_RS05390	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A6J80_RS05395	COG0416	fatty acid biosynthetic process
A6J80_RS05400	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A6J80_RS05405	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A6J80_RS05410	COG0776	regulation of translation
A6J80_RS05425	COG0717	Belongs to the dCTP deaminase family
A6J80_RS05435	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
A6J80_RS05440	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
A6J80_RS05445	COG1472	Belongs to the glycosyl hydrolase 3 family
A6J80_RS05455	COG0018	arginyl-trna synthetase
A6J80_RS05460	COG0513	Belongs to the DEAD box helicase family
A6J80_RS05465	COG0815	Transfers the fatty acyl group on membrane lipoproteins
A6J80_RS05470	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A6J80_RS05490	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A6J80_RS05510	COG2814	Major facilitator Superfamily
A6J80_RS05545	COG2205	protein histidine kinase activity
A6J80_RS05555	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A6J80_RS05560	COG0424	maF-like protein
A6J80_RS05565	COG1530	ribonuclease E activity
A6J80_RS05570	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
A6J80_RS05680	COG0842	Transport permease protein
A6J80_RS05715	COG0740	serine-type endopeptidase activity
A6J80_RS05735	COG1802	Transcriptional regulator
A6J80_RS05735	COG4626	Terminase
A6J80_RS05795	COG3243	poly(R)-hydroxyalkanoic acid synthase
A6J80_RS05810	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A6J80_RS05815	COG1278	Cold shock
A6J80_RS05830	COG0438	transferase activity, transferring glycosyl groups
A6J80_RS05835	COG3284	Transcriptional regulator
A6J80_RS05850	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A6J80_RS05860	COG1832	CoA-binding protein
A6J80_RS05885	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A6J80_RS05890	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A6J80_RS05895	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A6J80_RS05900	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A6J80_RS05905	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A6J80_RS05915	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6J80_RS05925	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A6J80_RS05945	COG0741	lytic transglycosylase activity
A6J80_RS05950	COG0629	single-stranded DNA binding
A6J80_RS05965	COG3609	addiction module antidote protein, CC2985 family
A6J80_RS05990	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A6J80_RS06015	COG0544	peptidyl-prolyl cis-trans isomerase activity
A6J80_RS06025	COG3750	Belongs to the UPF0335 family
A6J80_RS06035	COG1490	D-aminoacyl-tRNA deacylase activity
A6J80_RS06040	COG0513	Belongs to the DEAD box helicase family
A6J80_RS06045	COG1435	thymidine kinase activity
A6J80_RS06070	COG1028	Short-chain dehydrogenase reductase Sdr
A6J80_RS06080	COG0667	Aldo Keto reductase
A6J80_RS06105	COG0642	Histidine kinase
A6J80_RS06130	COG1960	acyl-CoA dehydrogenase activity
A6J80_RS06140	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A6J80_RS06145	COG0028	Belongs to the TPP enzyme family
A6J80_RS06160	COG0277	FAD linked oxidase domain protein
A6J80_RS06165	COG2354	Protein conserved in bacteria
A6J80_RS06180	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A6J80_RS06185	COG0640	Transcriptional regulator
A6J80_RS06190	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A6J80_RS06200	COG0006	proline dipeptidase activity
A6J80_RS06205	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
A6J80_RS06210	COG0598	Magnesium transport protein CorA
A6J80_RS06240	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A6J80_RS06275	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A6J80_RS06280	COG2862	Uncharacterized protein family, UPF0114
A6J80_RS06290	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
A6J80_RS06295	COG4208	sulfate ABC transporter
A6J80_RS06305	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
A6J80_RS06320	COG0131	Imidazoleglycerol-phosphate dehydratase
A6J80_RS06325	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A6J80_RS06335	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
A6J80_RS06340	COG0107	imidazoleglycerol-phosphate synthase activity
A6J80_RS06345	COG0140	phosphoribosyl-ATP diphosphatase activity
A6J80_RS06350	COG1285	pathogenesis
A6J80_RS06355	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
A6J80_RS06370	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6J80_RS06385	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
A6J80_RS06410	COG4175	Glycine betaine
A6J80_RS06425	COG0583	DNA-binding transcription factor activity
A6J80_RS06430	COG0217	transcriptional regulatory protein
A6J80_RS06445	COG0114	fumarate hydratase activity
A6J80_RS06475	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
A6J80_RS06480	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A6J80_RS06490	COG1228	amidohydrolase
A6J80_RS06495	COG1671	Belongs to the UPF0178 family
A6J80_RS06520	COG0552	protein localization to endoplasmic reticulum
A6J80_RS06540	COG0521	Mo-molybdopterin cofactor biosynthetic process
A6J80_RS06545	COG0137	argininosuccinate synthase activity
A6J80_RS06555	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A6J80_RS06570	COG0494	nUDIX hydrolase
A6J80_RS06590	COG1968	undecaprenyl-diphosphatase activity
A6J80_RS06615	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A6J80_RS06630	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A6J80_RS06645	COG0354	folic acid binding
A6J80_RS06655	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A6J80_RS06670	COG0848	biopolymer transport protein
A6J80_RS06680	COG1253	flavin adenine dinucleotide binding
A6J80_RS06690	COG1902	pentaerythritol trinitrate reductase activity
A6J80_RS06695	COG0483	inositol monophosphate 1-phosphatase activity
A6J80_RS06705	COG0741	lytic transglycosylase activity
A6J80_RS06705	COG0739	heme binding
A6J80_RS06705	COG1196	nuclear chromosome segregation
A6J80_RS06710	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A6J80_RS06715	COG1320	monovalent cation:proton antiporter activity
A6J80_RS06720	COG2212	antiporter activity
A6J80_RS06725	COG1863	multisubunit Na H antiporter MnhE subunit
A6J80_RS06730	COG0651	ATP synthesis coupled electron transport
A6J80_RS06735	COG1006	Multisubunit Na H antiporter MnhC subunit
A6J80_RS06740	COG2111	Na H antiporter
A6J80_RS06740	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A6J80_RS06745	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
A6J80_RS06750	COG0632	four-way junction helicase activity
A6J80_RS06755	COG0501	Belongs to the peptidase M48B family
A6J80_RS06760	COG2255	four-way junction helicase activity
A6J80_RS06770	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A6J80_RS06775	COG0037	tRNA processing
A6J80_RS06785	COG2885	chlorophyll binding
A6J80_RS06790	COG0823	Involved in the tonB-independent uptake of proteins
A6J80_RS06800	COG0848	biopolymer transport protein
A6J80_RS06810	COG0824	Thioesterase
A6J80_RS06835	COG0405	Gamma-glutamyltransferase
A6J80_RS06840	COG1754	DNA topoisomerase type I activity
A6J80_RS06840	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A6J80_RS06855	COG0175	sulfate reduction
A6J80_RS06870	COG1522	sequence-specific DNA binding
A6J80_RS06875	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A6J80_RS06885	COG0534	Mate efflux family protein
A6J80_RS06890	COG3034	peptidoglycan biosynthetic process
A6J80_RS06895	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
A6J80_RS06900	COG0242	peptide deformylase activity
A6J80_RS06905	COG0242	peptide deformylase activity
A6J80_RS06915	COG0242	peptide deformylase activity
A6J80_RS06930	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A6J80_RS06935	COG1643	Atp-dependent helicase
A6J80_RS06945	COG3106	COG3106 Predicted ATPase
A6J80_RS06950	COG3768	UPF0283 membrane protein
A6J80_RS06955	COG4953	penicillin-binding protein 1C
A6J80_RS06970	COG0306	phosphate transporter
A6J80_RS07050	COG3781	membrane
A6J80_RS07055	COG4993	Dehydrogenase
A6J80_RS07075	COG0587	DNA-directed DNA polymerase activity
A6J80_RS07090	COG1126	abc transporter atp-binding protein
A6J80_RS07095	COG0765	amino acid transport
A6J80_RS07150	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A6J80_RS07155	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A6J80_RS07160	COG2350	Protein conserved in bacteria
A6J80_RS07170	COG1132	(ABC) transporter
A6J80_RS07180	COG1652	LysM domain
A6J80_RS07185	COG0318	PFAM AMP-dependent synthetase and ligase
A6J80_RS07215	COG2884	Cell division ATP-binding protein ftsE
A6J80_RS07230	COG1131	(ABC) transporter
A6J80_RS07235	COG0842	Transport permease protein
A6J80_RS07245	COG1278	Cold shock
A6J80_RS07255	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A6J80_RS07265	COG0019	diaminopimelate decarboxylase activity
A6J80_RS07275	COG0165	Argininosuccinate lyase
A6J80_RS07280	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A6J80_RS07285	COG2818	Glycosylase
A6J80_RS07290	COG2200	EAL domain
A6J80_RS07290	COG2771	luxR family
A6J80_RS07320	COG0142	geranyltranstransferase activity
A6J80_RS07325	COG0004	ammonium transporteR
A6J80_RS07340	COG2853	Lipoprotein
A6J80_RS07345	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
A6J80_RS07355	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A6J80_RS07360	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A6J80_RS07365	COG0842	Transport permease protein
A6J80_RS07380	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6J80_RS07385	COG0010	Belongs to the arginase family
A6J80_RS07405	COG1519	Transferase
A6J80_RS07410	COG1663	tetraacyldisaccharide 4'-kinase activity
A6J80_RS07425	COG1194	a g-specific adenine glycosylase
A6J80_RS07450	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A6J80_RS07455	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
A6J80_RS07460	COG2223	nitrite transmembrane transporter activity
A6J80_RS07490	COG1815	bacterial-type flagellum-dependent cell motility
A6J80_RS07495	COG1558	bacterial-type flagellum-dependent cell motility
A6J80_RS07500	COG1677	Flagellar hook-basal body complex protein FliE
A6J80_RS07505	COG1987	bacterial-type flagellum assembly
A6J80_RS07510	COG4786	Flagellar basal body rod
A6J80_RS07515	COG4786	Flagellar basal body rod
A6J80_RS07520	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
A6J80_RS07525	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
A6J80_RS07560	COG3153	acetyltransferase
A6J80_RS07560	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A6J80_RS07580	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
A6J80_RS07585	COG1335	isochorismatase
A6J80_RS07590	COG1054	Belongs to the UPF0176 family
A6J80_RS07595	COG0280	phosphate acetyltransferase
A6J80_RS07595	COG0281	malic enzyme
A6J80_RS07620	COG1215	transferase activity, transferring glycosyl groups
A6J80_RS07640	COG0438	transferase activity, transferring glycosyl groups
A6J80_RS07650	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A6J80_RS07650	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A6J80_RS07685	COG3842	ATPase activity
A6J80_RS07695	COG0395	ABC-type sugar transport system, permease component
A6J80_RS07710	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A6J80_RS07735	COG2308	Evidence 4 Homologs of previously reported genes of
A6J80_RS07770	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A6J80_RS07780	COG3830	Belongs to the UPF0237 family
A6J80_RS07780	COG0560	Phosphoserine phosphatase
A6J80_RS07785	COG1183	phosphatidylcholine synthase activity
A6J80_RS07790	COG0747	negative chemotaxis
A6J80_RS07805	COG1376	ErfK ybiS ycfS ynhG family protein
A6J80_RS07810	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A6J80_RS07825	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A6J80_RS07840	COG2301	Belongs to the HpcH HpaI aldolase family
A6J80_RS07855	COG1126	abc transporter atp-binding protein
A6J80_RS07860	COG0765	amino acid transport
A6J80_RS07865	COG4597	amino acid ABC transporter
A6J80_RS07870	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6J80_RS07880	COG0546	phosphoglycolate phosphatase activity
A6J80_RS07885	COG0564	pseudouridine synthase activity
A6J80_RS07890	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A6J80_RS07895	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A6J80_RS07900	COG3916	Acyl-homoserine-lactone synthase
A6J80_RS07910	COG0203	ribosomal protein L17
A6J80_RS07915	COG0202	RNA polymerase activity
A6J80_RS07920	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A6J80_RS07925	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A6J80_RS07930	COG0563	adenylate kinase activity
A6J80_RS07935	COG0201	protein transport
A6J80_RS07940	COG0200	Binds to the 23S rRNA
A6J80_RS07950	COG1841	ribosomal large subunit assembly
A6J80_RS07955	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A6J80_RS07960	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A6J80_RS07965	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A6J80_RS07970	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A6J80_RS07975	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A6J80_RS07980	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A6J80_RS07985	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A6J80_RS07990	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A6J80_RS07995	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A6J80_RS08000	COG0255	Belongs to the universal ribosomal protein uL29 family
A6J80_RS08005	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A6J80_RS08010	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A6J80_RS08015	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A6J80_RS08020	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A6J80_RS08025	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A6J80_RS08030	COG0089	rRNA binding
A6J80_RS08035	COG0088	Forms part of the polypeptide exit tunnel
A6J80_RS08040	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A6J80_RS08045	COG0051	transcription antitermination factor activity, RNA binding
A6J80_RS08050	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A6J80_RS08055	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A6J80_RS08060	COG0049	tRNA binding
A6J80_RS08065	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A6J80_RS08075	COG0697	spore germination
A6J80_RS08080	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A6J80_RS08085	COG0085	RNA polymerase activity
A6J80_RS08090	COG0222	ribosome binding
A6J80_RS08095	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A6J80_RS08100	COG0081	regulation of translation
A6J80_RS08105	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A6J80_RS08110	COG0250	Participates in transcription elongation, termination and antitermination
A6J80_RS08115	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A6J80_RS08135	COG0473	3-isopropylmalate dehydrogenase activity
A6J80_RS08140	COG1573	uracil-dna glycosylase
A6J80_RS08150	COG1678	Uncharacterized ACR, COG1678
A6J80_RS08155	COG0009	L-threonylcarbamoyladenylate synthase
A6J80_RS08160	COG1960	acyl-CoA dehydrogenase activity
A6J80_RS08200	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A6J80_RS08215	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
A6J80_RS08220	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
A6J80_RS08225	COG0736	holo-[acyl-carrier-protein] synthase activity
A6J80_RS08230	COG0681	Belongs to the peptidase S26 family
A6J80_RS08235	COG0571	ribonuclease III activity
A6J80_RS08240	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A6J80_RS08265	COG1201	RNA secondary structure unwinding
A6J80_RS08270	COG1793	dna ligase
A6J80_RS08290	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A6J80_RS08295	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A6J80_RS08310	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A6J80_RS08315	COG0142	geranyltranstransferase activity
A6J80_RS08325	COG0123	including yeast histone deacetylase and acetoin utilization protein
A6J80_RS08330	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A6J80_RS08335	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A6J80_RS08355	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A6J80_RS08370	COG2133	pyrroloquinoline quinone binding
A6J80_RS08380	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
A6J80_RS08385	COG0612	Peptidase, M16
A6J80_RS08390	COG0612	Peptidase, M16
A6J80_RS08400	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A6J80_RS08405	COG0138	bifunctional purine biosynthesis protein purh
A6J80_RS08430	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A6J80_RS08445	COG4154	Belongs to the RbsD FucU family
A6J80_RS08450	COG0656	L-ascorbic acid biosynthetic process
A6J80_RS08470	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A6J80_RS08490	COG1070	Carbohydrate kinase
A6J80_RS08495	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A6J80_RS08500	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A6J80_RS08510	COG3158	transport of potassium into the cell
A6J80_RS08515	COG4191	Histidine kinase
A6J80_RS08520	COG0745	RESPONSE REGULATOR receiver
A6J80_RS08525	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A6J80_RS08535	COG0346	lactoylglutathione lyase activity
A6J80_RS08550	COG0346	lactoylglutathione lyase activity
A6J80_RS08560	COG0159	tryptophan synthase activity
A6J80_RS08565	COG0012	GTP binding
A6J80_RS08610	COG1131	(ABC) transporter
A6J80_RS08625	COG2205	protein histidine kinase activity
A6J80_RS08630	COG0745	RESPONSE REGULATOR receiver
A6J80_RS08675	COG0714	Associated with various cellular activities
A6J80_RS08695	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A6J80_RS08695	COG0116	Belongs to the methyltransferase superfamily
A6J80_RS08700	COG2514	catechol 2,3-dioxygenase activity
A6J80_RS08705	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
A6J80_RS08710	COG1597	lipid kinase activity
A6J80_RS08720	COG1535	isochorismatase
A6J80_RS08720	COG3433	isochorismatase activity
A6J80_RS08725	COG1028	Short-chain dehydrogenase reductase Sdr
A6J80_RS08735	COG1021	2,3-dihydroxybenzoate-AMP ligase
A6J80_RS08740	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A6J80_RS08760	COG0583	DNA-binding transcription factor activity
A6J80_RS08770	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
A6J80_RS08775	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A6J80_RS08805	COG1473	amidohydrolase
A6J80_RS08810	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A6J80_RS08840	COG0509	glycine decarboxylation via glycine cleavage system
A6J80_RS08845	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A6J80_RS08850	COG1028	Short-chain dehydrogenase reductase Sdr
A6J80_RS08855	COG2205	protein histidine kinase activity
A6J80_RS08855	COG0784	Response regulator, receiver
A6J80_RS08855	COG5002	protein histidine kinase activity
A6J80_RS08870	COG0535	radical SAM domain protein
A6J80_RS08875	COG0535	radical SAM domain protein
A6J80_RS08880	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
A6J80_RS08885	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A6J80_RS08900	COG2373	Large extracellular alpha-helical protein
A6J80_RS08910	COG1012	belongs to the aldehyde dehydrogenase family
A6J80_RS08925	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A6J80_RS08930	COG2835	tetraacyldisaccharide 4'-kinase activity
A6J80_RS08940	COG3118	belongs to the thioredoxin family
A6J80_RS08950	COG0745	RESPONSE REGULATOR receiver
A6J80_RS08965	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
A6J80_RS08985	COG1309	transcriptional regulator
A6J80_RS08995	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A6J80_RS09005	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A6J80_RS09015	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
A6J80_RS09050	COG1338	Plays a role in the flagellum-specific transport system
A6J80_RS09060	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6J80_RS09070	COG0514	ATP-dependent DNA helicase (RecQ)
A6J80_RS09090	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
A6J80_RS09105	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
A6J80_RS09125	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A6J80_RS09140	COG2094	Belongs to the DNA glycosylase MPG family
A6J80_RS09150	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A6J80_RS09175	COG1172	Belongs to the binding-protein-dependent transport system permease family
A6J80_RS09185	COG1879	ABC-type sugar transport system periplasmic component
A6J80_RS09190	COG2207	Transcriptional regulator
A6J80_RS09190	COG3708	Transcriptional regulator
A6J80_RS09195	COG1070	Carbohydrate kinase
A6J80_RS09200	COG1063	alcohol dehydrogenase
A6J80_RS09235	COG0438	transferase activity, transferring glycosyl groups
A6J80_RS09255	COG3685	Protein conserved in bacteria
A6J80_RS09260	COG3920	Histidine kinase
A6J80_RS09260	COG2202	Pas domain
A6J80_RS09275	COG4176	ABC-type proline glycine betaine transport system permease component
A6J80_RS09280	COG4175	Glycine betaine
A6J80_RS09280	COG0517	IMP dehydrogenase activity
A6J80_RS09290	COG2423	ornithine cyclodeaminase activity
A6J80_RS09300	COG0243	molybdopterin cofactor binding
A6J80_RS09305	COG0183	Belongs to the thiolase family
A6J80_RS09315	COG0725	ABC transporter, periplasmic molybdate-binding protein
A6J80_RS09320	COG4149	molybdate abc transporter
A6J80_RS09360	COG0495	leucyl-tRNA aminoacylation
A6J80_RS09380	COG0625	glutathione transferase activity
A6J80_RS09385	COG2271	Major facilitator Superfamily
A6J80_RS09390	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
A6J80_RS09410	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A6J80_RS09430	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
A6J80_RS09440	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
A6J80_RS09445	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
A6J80_RS09450	COG3030	protein affecting phage T7 exclusion by the F plasmid
A6J80_RS09470	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
A6J80_RS09475	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
A6J80_RS09495	COG2887	Belongs to the helicase family. UvrD subfamily
A6J80_RS09500	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
A6J80_RS09505	COG3178	'Phosphotransferase
A6J80_RS09510	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A6J80_RS09515	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A6J80_RS09525	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A6J80_RS09535	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6J80_RS09540	COG0564	pseudouridine synthase activity
A6J80_RS09575	COG1959	2 iron, 2 sulfur cluster binding
A6J80_RS09580	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A6J80_RS09585	COG0237	dephospho-CoA kinase activity
A6J80_RS09590	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A6J80_RS09615	COG0784	Response regulator, receiver
A6J80_RS09625	COG0667	Aldo Keto reductase
A6J80_RS09630	COG0582	viral genome integration into host DNA
A6J80_RS09715	COG0582	viral genome integration into host DNA
A6J80_RS09720	COG0582	viral genome integration into host DNA
A6J80_RS09780	COG3276	selenocysteine insertion sequence binding
A6J80_RS09795	COG2864	formate dehydrogenase
A6J80_RS09800	COG0437	4 iron, 4 sulfur cluster binding
A6J80_RS09815	COG4638	Rieske (2fe-2S)
A6J80_RS09820	COG2358	TRAP transporter, solute receptor (TAXI family
A6J80_RS09825	COG1981	membrane
A6J80_RS09830	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A6J80_RS09835	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A6J80_RS09840	COG0445	tRNA wobble uridine modification
A6J80_RS09845	COG0357	Ribosomal RNA small subunit methyltransferase G
A6J80_RS09860	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A6J80_RS09865	COG1420	regulation of RNA biosynthetic process
A6J80_RS09875	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A6J80_RS09885	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A6J80_RS09890	COG2832	Protein of unknown function (DUF454)
A6J80_RS09895	COG3791	Glutathione-dependent formaldehyde-activating
A6J80_RS09910	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
A6J80_RS09915	COG0746	molybdenum cofactor guanylyltransferase activity
A6J80_RS09920	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A6J80_RS09930	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
A6J80_RS09935	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A6J80_RS09940	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A6J80_RS09950	COG2022	thiamine diphosphate biosynthetic process
A6J80_RS09965	COG0351	phosphomethylpyrimidine kinase
A6J80_RS09980	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A6J80_RS09985	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
A6J80_RS09995	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A6J80_RS10010	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A6J80_RS10025	COG1185	polyribonucleotide nucleotidyltransferase activity
A6J80_RS10035	COG1442	glycosyl transferase family 8
A6J80_RS10040	COG0450	alkyl hydroperoxide reductase
A6J80_RS10050	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A6J80_RS10055	COG3842	ATPase activity
A6J80_RS10065	COG1175	transmembrane transport
A6J80_RS10070	COG3833	ABC-type maltose transport systems, permease component
A6J80_RS10075	COG1028	Short-chain dehydrogenase reductase Sdr
A6J80_RS10080	COG1802	Transcriptional regulator
A6J80_RS10085	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A6J80_RS10100	COG0129	dihydroxy-acid dehydratase activity
A6J80_RS10105	COG1028	Short-chain dehydrogenase reductase Sdr
A6J80_RS10110	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A6J80_RS10125	COG0179	Fumarylacetoacetate (FAA) hydrolase
A6J80_RS10130	COG3622	Belongs to the hyi family
A6J80_RS10135	COG2084	Dehydrogenase
A6J80_RS10150	COG3386	PFAM SMP-30 Gluconolaconase
A6J80_RS10155	COG0800	Aldolase
A6J80_RS10160	COG3734	2-keto-3-deoxy-galactonokinase
A6J80_RS10170	COG0129	dihydroxy-acid dehydratase activity
A6J80_RS10175	COG4214	carbohydrate transport
A6J80_RS10180	COG1129	ABC transporter
A6J80_RS10185	COG4213	ABC transporter substrate-binding protein
A6J80_RS10200	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A6J80_RS10210	COG1346	cytolysis
A6J80_RS10240	COG1028	Short-chain dehydrogenase reductase Sdr
A6J80_RS10255	COG0730	response to heat
A6J80_RS10260	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
A6J80_RS10265	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A6J80_RS10270	COG3103	Sh3 type 3 domain protein
A6J80_RS10270	COG0791	NLP P60 protein
A6J80_RS10270	COG1388	LysM domain
A6J80_RS10275	COG1706	bacterial-type flagellum-dependent cell motility
A6J80_RS10295	COG1360	Flagellar Motor Protein
A6J80_RS10305	COG2995	paraquat-inducible protein a
A6J80_RS10310	COG3008	intermembrane lipid transfer
A6J80_RS10335	COG0312	modulator of DNA gyrase
A6J80_RS10360	COG0837	glucose binding
A6J80_RS10365	COG0729	surface antigen
A6J80_RS10370	COG2911	Protein conserved in bacteria
A6J80_RS10415	COG0154	amidase activity
A6J80_RS10420	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A6J80_RS10455	COG3547	Transposase (IS116 IS110 IS902 family)
A6J80_RS10465	COG0284	orotidine-5'-phosphate decarboxylase activity
A6J80_RS10475	COG0033	Phosphoglucomutase
A6J80_RS10480	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A6J80_RS10485	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
A6J80_RS10540	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A6J80_RS10570	COG2358	TRAP transporter, solute receptor (TAXI family
A6J80_RS10575	COG0306	phosphate transporter
A6J80_RS10580	COG2031	fatty acid transporter
A6J80_RS10585	COG1115	amino acid carrier protein
A6J80_RS10800	COG2948	multi-organism process
A6J80_RS10815	COG3846	protein secretion by the type IV secretion system
A6J80_RS10830	COG3451	type IV secretory pathway VirB4
A6J80_RS10855	COG4962	Type ii secretion system protein e
A6J80_RS10875	COG0583	DNA-binding transcription factor activity
A6J80_RS10945	COG4638	Rieske (2fe-2S)
A6J80_RS10965	COG3845	ABC transporter
A6J80_RS10970	COG4603	Belongs to the binding-protein-dependent transport system permease family
A6J80_RS10975	COG1079	Belongs to the binding-protein-dependent transport system permease family
A6J80_RS11020	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A6J80_RS11060	COG2963	transposase activity
A6J80_RS11065	COG3436	PFAM IS66 Orf2 family protein
A6J80_RS11070	COG4372	Transposase
A6J80_RS11100	COG2132	Multicopper oxidase
A6J80_RS11135	COG1937	Protein conserved in bacteria
A6J80_RS11155	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A6J80_RS11170	COG0789	Transcriptional regulator
A6J80_RS11235	COG0210	DNA helicase
A6J80_RS11235	COG0210	DNA helicase
A6J80_RS11295	COG0583	DNA-binding transcription factor activity
A6J80_RS11330	COG1732	Glycine betaine
A6J80_RS11335	COG1174	glycine betaine transport
A6J80_RS11340	COG1125	glycine betaine transport
A6J80_RS11345	COG1174	glycine betaine transport
A6J80_RS11410	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
A6J80_RS11415	COG1122	ATPase activity
A6J80_RS11425	COG3842	ATPase activity
A6J80_RS11430	COG0395	ABC-type sugar transport system, permease component
A6J80_RS11435	COG1175	transmembrane transport
A6J80_RS11440	COG1653	transport
A6J80_RS11450	COG1454	alcohol dehydrogenase
A6J80_RS11455	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A6J80_RS11465	COG0659	secondary active sulfate transmembrane transporter activity
A6J80_RS11480	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6J80_RS11485	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
A6J80_RS11485	COG0517	IMP dehydrogenase activity
A6J80_RS11500	COG1137	ATPase activity
A6J80_RS11505	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A6J80_RS11510	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6J80_RS11520	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A6J80_RS11525	COG1846	Transcriptional regulator
A6J80_RS11530	COG0745	RESPONSE REGULATOR receiver
A6J80_RS11535	COG0653	protein targeting
A6J80_RS11540	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A6J80_RS11545	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
A6J80_RS11550	COG0494	nUDIX hydrolase
A6J80_RS11555	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A6J80_RS11570	COG0779	Required for maturation of 30S ribosomal subunits
A6J80_RS11575	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
A6J80_RS11595	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A6J80_RS11600	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A6J80_RS11605	COG1040	competence protein
A6J80_RS11635	COG3034	peptidoglycan biosynthetic process
A6J80_RS11645	COG1132	(ABC) transporter
A6J80_RS11650	COG0617	tRNA 3'-terminal CCA addition
A6J80_RS11655	COG0494	nUDIX hydrolase
A6J80_RS11670	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
A6J80_RS11690	COG1850	ribulose-bisphosphate carboxylase activity
A6J80_RS11720	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
A6J80_RS11725	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6J80_RS11740	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
A6J80_RS11740	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A6J80_RS11760	COG0425	Belongs to the sulfur carrier protein TusA family
A6J80_RS11760	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A6J80_RS11765	COG1618	nucleotide phosphatase activity, acting on free nucleotides
A6J80_RS11765	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
A6J80_RS11770	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A6J80_RS11775	COG0540	Belongs to the ATCase OTCase family
A6J80_RS11780	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A6J80_RS11785	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
A6J80_RS11790	COG1250	3-hydroxyacyl-CoA dehydrogenase
A6J80_RS11815	COG0300	oxidoreductase activity
A6J80_RS11820	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A6J80_RS11865	COG1127	ABC transporter
A6J80_RS11870	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A6J80_RS11880	COG0583	DNA-binding transcription factor activity
A6J80_RS11905	COG0742	ribosomal rna small subunit methyltransferase
A6J80_RS11925	COG5507	3-demethylubiquinone-9 3-methyltransferase
A6J80_RS11950	COG0525	valine-tRNA ligase activity
A6J80_RS11975	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A6J80_RS11975	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
A6J80_RS11985	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A6J80_RS11990	COG0825	malonyl-CoA metabolic process
A6J80_RS11995	COG0314	molybdopterin synthase activity
A6J80_RS12005	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A6J80_RS12010	COG3443	Belongs to the bacterial solute-binding protein 9 family
A6J80_RS12015	COG0322	excinuclease ABC activity
A6J80_RS12020	COG0616	signal peptide processing
A6J80_RS12020	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A6J80_RS12045	COG2003	Belongs to the UPF0758 family
A6J80_RS12050	COG0484	heat shock protein binding
A6J80_RS12055	COG0443	Heat shock 70 kDa protein
A6J80_RS12065	COG1218	3'(2'),5'-bisphosphate nucleotidase
A6J80_RS12070	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
A6J80_RS12115	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A6J80_RS12120	COG0625	glutathione transferase activity
A6J80_RS12130	COG3119	arylsulfatase activity
A6J80_RS12150	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A6J80_RS12160	COG0066	3-isopropylmalate dehydratase activity
A6J80_RS12170	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A6J80_RS12180	COG0799	negative regulation of ribosome biogenesis
A6J80_RS12185	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
A6J80_RS12200	COG2171	N-acyltransferase activity
A6J80_RS12215	COG2951	lytic endotransglycosylase activity
A6J80_RS12250	COG0494	nUDIX hydrolase
A6J80_RS12255	COG0793	Belongs to the peptidase S41A family
A6J80_RS12265	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
A6J80_RS12280	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A6J80_RS12315	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A6J80_RS12335	COG0469	pyruvate kinase activity
A6J80_RS12345	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A6J80_RS12350	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A6J80_RS12355	COG2124	cytochrome p450
A6J80_RS12365	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A6J80_RS12380	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6J80_RS12380	COG0072	phenylalanine-tRNA ligase activity
A6J80_RS12385	COG0625	glutathione transferase activity
A6J80_RS12390	COG1970	mechanosensitive ion channel activity
A6J80_RS12395	COG1522	sequence-specific DNA binding
A6J80_RS12400	COG0828	Belongs to the bacterial ribosomal protein bS21 family
A6J80_RS12410	COG1028	Short-chain dehydrogenase reductase Sdr
A6J80_RS12410	COG0604	alcohol dehydrogenase
A6J80_RS12410	COG3321	synthase
A6J80_RS12430	COG3191	aminopeptidase activity
A6J80_RS12435	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6J80_RS12465	COG3047	cAMP biosynthetic process
A6J80_RS12465	COG2885	chlorophyll binding
A6J80_RS12480	COG2897	thiosulfate sulfurtransferase activity
A6J80_RS12485	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A6J80_RS12490	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A6J80_RS12495	COG0477	Major facilitator Superfamily
A6J80_RS12505	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A6J80_RS12510	COG0628	permease
A6J80_RS12515	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A6J80_RS12525	COG0586	Pfam SNARE associated Golgi protein
A6J80_RS12530	COG2321	neutral zinc metallopeptidase
A6J80_RS12540	COG2867	negative regulation of translational initiation
A6J80_RS12555	COG0604	alcohol dehydrogenase
A6J80_RS12560	COG0657	acetylesterase activity
A6J80_RS12580	COG1012	belongs to the aldehyde dehydrogenase family
A6J80_RS12585	COG0477	Major facilitator Superfamily
A6J80_RS12590	COG0583	DNA-binding transcription factor activity
A6J80_RS12605	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A6J80_RS12610	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A6J80_RS12635	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6J80_RS12640	COG1522	sequence-specific DNA binding
A6J80_RS12645	COG0277	FAD linked oxidase domain protein
A6J80_RS12650	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A6J80_RS12650	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A6J80_RS12670	COG0228	four-way junction DNA binding
A6J80_RS12675	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A6J80_RS12690	COG0335	large ribosomal subunit rRNA binding
A6J80_RS12695	COG0254	rRNA binding
A6J80_RS12710	COG1192	Involved in chromosome partitioning
A6J80_RS12725	COG0693	protein deglycase activity
A6J80_RS12730	COG0508	dehydrogenase complex catalyzes the overall conversion of
A6J80_RS12735	COG0508	dehydrogenase complex catalyzes the overall conversion of
A6J80_RS12735	COG0022	dehydrogenase e1 component
A6J80_RS12740	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A6J80_RS12765	COG1012	belongs to the aldehyde dehydrogenase family
A6J80_RS12770	COG3622	Belongs to the hyi family
A6J80_RS12780	COG0714	Associated with various cellular activities
A6J80_RS12800	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A6J80_RS12805	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A6J80_RS12810	COG3494	Protein of unknown function (DUF1009)
A6J80_RS12815	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A6J80_RS12820	COG0251	oxidation-reduction process
A6J80_RS12840	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A6J80_RS12850	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A6J80_RS12855	COG5328	Belongs to the UPF0262 family
A6J80_RS12870	COG0129	dihydroxy-acid dehydratase activity
A6J80_RS12885	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A6J80_RS12895	COG0166	Belongs to the GPI family
A6J80_RS12905	COG2968	Membrane
A6J80_RS12920	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A6J80_RS12935	COG2900	Belongs to the SlyX family
A6J80_RS12940	COG0124	histidyl-tRNA synthetase
A6J80_RS12945	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
A6J80_RS12950	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A6J80_RS12955	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A6J80_RS12965	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A6J80_RS12985	COG0446	pyridine nucleotide-disulphide oxidoreductase
A6J80_RS12985	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A6J80_RS12990	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A6J80_RS13020	COG1160	GTP binding
A6J80_RS13030	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A6J80_RS13040	COG1703	isobutyryl-CoA mutase activity
A6J80_RS13045	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A6J80_RS13055	COG1376	ErfK ybiS ycfS ynhG family protein
A6J80_RS13060	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
A6J80_RS13065	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
A6J80_RS13070	COG1079	Belongs to the binding-protein-dependent transport system permease family
A6J80_RS13075	COG4603	Belongs to the binding-protein-dependent transport system permease family
A6J80_RS13080	COG3845	ABC transporter
A6J80_RS13085	COG1744	ABC transporter substrate-binding protein PnrA-like
A6J80_RS13090	COG0456	acetyltransferase
A6J80_RS13100	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
A6J80_RS13120	COG0101	tRNA pseudouridine synthase activity
A6J80_RS13135	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A6J80_RS13145	COG0752	glycyl-tRNA synthetase alpha subunit
A6J80_RS13155	COG0751	glycine-tRNA ligase activity
A6J80_RS13160	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A6J80_RS13160	COG0574	Belongs to the PEP-utilizing enzyme family
A6J80_RS13170	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A6J80_RS13175	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A6J80_RS13180	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A6J80_RS13185	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A6J80_RS13205	COG0583	DNA-binding transcription factor activity
A6J80_RS13240	COG0508	dehydrogenase complex catalyzes the overall conversion of
A6J80_RS13245	COG0567	Dehydrogenase, E1 component
A6J80_RS13255	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A6J80_RS13265	COG0045	succinate-CoA ligase (ADP-forming) activity
A6J80_RS13300	COG2030	dehydratase
A6J80_RS13340	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
A6J80_RS13345	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A6J80_RS13350	COG0154	amidase activity
A6J80_RS13360	COG3023	N-Acetylmuramoyl-L-alanine amidase
A6J80_RS13365	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
A6J80_RS13375	COG0489	protein tyrosine kinase activity
A6J80_RS13380	COG2001	Belongs to the MraZ family
A6J80_RS13385	COG0275	rRNA processing
A6J80_RS13395	COG0768	penicillin binding
A6J80_RS13400	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A6J80_RS13410	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A6J80_RS13415	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A6J80_RS13420	COG0058	SHG alpha-glucan phosphorylase activity
A6J80_RS13430	COG0297	glycogen (starch) synthase activity
A6J80_RS13435	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
A6J80_RS13440	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
A6J80_RS13445	COG0366	Alpha amylase catalytic
A6J80_RS13465	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A6J80_RS13475	COG3185	4-Hydroxyphenylpyruvate dioxygenase
A6J80_RS13475	COG1082	Xylose isomerase domain protein TIM barrel
A6J80_RS13480	COG1053	succinate dehydrogenase
A6J80_RS13500	COG1999	signal sequence binding
A6J80_RS13510	COG5000	phosphorelay sensor kinase activity
A6J80_RS13520	COG0594	ribonuclease P activity
A6J80_RS13525	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
A6J80_RS13530	COG0037	tRNA processing
A6J80_RS13540	COG0706	membrane insertase activity
A6J80_RS13550	COG0218	Necessary for normal cell division and for the maintenance of normal septation
A6J80_RS13555	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A6J80_RS13565	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A6J80_RS13575	COG0494	nUDIX hydrolase
A6J80_RS13585	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
A6J80_RS13585	COG3264	Mechanosensitive ion channel
A6J80_RS13590	COG0477	Major facilitator Superfamily
A6J80_RS13595	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
A6J80_RS13600	COG0285	dihydrofolate synthase activity
A6J80_RS13605	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
A6J80_RS13615	COG2154	pterin-4-alpha-carbinolamine dehydratase
A6J80_RS13635	COG1546	Belongs to the CinA family
A6J80_RS13635	COG1058	Belongs to the CinA family
A6J80_RS13640	COG0024	Methionine aminopeptidase
A6J80_RS13645	COG1609	Transcriptional regulator
A6J80_RS13670	COG0019	diaminopimelate decarboxylase activity
A6J80_RS13685	COG2945	thiolester hydrolase activity
A6J80_RS13695	COG0538	isocitrate dehydrogenase activity
A6J80_RS13700	COG0047	phosphoribosylformylglycinamidine synthase activity
A6J80_RS13710	COG2204	response regulator
A6J80_RS13715	COG1530	ribonuclease E activity
A6J80_RS13720	COG0785	Cytochrome C biogenesis protein
A6J80_RS13730	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A6J80_RS13735	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A6J80_RS13790	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A6J80_RS13845	COG0464	growth
A6J80_RS13850	COG1404	Belongs to the peptidase S8 family
A6J80_RS13950	COG3800	Transcriptional regulator
A6J80_RS13950	COG1396	sequence-specific DNA binding
A6J80_RS14020	COG2855	membrane
A6J80_RS14025	COG0028	Belongs to the TPP enzyme family
A6J80_RS14040	COG1414	Transcriptional regulator
A6J80_RS14070	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A6J80_RS14095	COG1609	Transcriptional regulator
A6J80_RS14100	COG1012	belongs to the aldehyde dehydrogenase family
A6J80_RS14105	COG0318	PFAM AMP-dependent synthetase and ligase
A6J80_RS14110	COG2271	Major facilitator Superfamily
A6J80_RS14115	COG0028	Belongs to the TPP enzyme family
A6J80_RS14120	COG2855	membrane
A6J80_RS14135	COG1228	amidohydrolase
A6J80_RS14140	COG0583	DNA-binding transcription factor activity
A6J80_RS14145	COG0747	negative chemotaxis
A6J80_RS14155	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A6J80_RS14160	COG0444	Belongs to the ABC transporter superfamily
A6J80_RS14170	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A6J80_RS14175	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A6J80_RS14180	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A6J80_RS14190	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
A6J80_RS14190	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A6J80_RS14200	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A6J80_RS14205	COG0028	Belongs to the TPP enzyme family
A6J80_RS14210	COG2855	membrane
A6J80_RS14225	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
A6J80_RS14280	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A6J80_RS14295	COG0745	RESPONSE REGULATOR receiver
A6J80_RS14300	COG0346	lactoylglutathione lyase activity
A6J80_RS14315	COG0778	Nitroreductase
A6J80_RS14325	COG0149	triose-phosphate isomerase activity
A6J80_RS14335	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A6J80_RS14355	COG2917	probably involved in intracellular septation
A6J80_RS14365	COG1469	GTP cyclohydrolase I activity
A6J80_RS14370	COG0210	DNA helicase
A6J80_RS14375	COG0702	epimerase
A6J80_RS14380	COG1733	regulation of RNA biosynthetic process
A6J80_RS14395	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A6J80_RS14400	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A6J80_RS14405	COG1012	belongs to the aldehyde dehydrogenase family
A6J80_RS14415	COG0583	DNA-binding transcription factor activity
A6J80_RS14425	COG3448	diguanylate cyclase activity
A6J80_RS14425	COG4175	Glycine betaine
A6J80_RS14430	COG4176	ABC-type proline glycine betaine transport system permease component
A6J80_RS14435	COG4176	ABC-type proline glycine betaine transport system permease component
A6J80_RS14450	COG2217	Heavy metal translocating P-type atpase
A6J80_RS14455	COG0789	Transcriptional regulator
A6J80_RS14470	COG3547	Transposase (IS116 IS110 IS902 family)
A6J80_RS14475	COG0659	secondary active sulfate transmembrane transporter activity
A6J80_RS14480	COG1464	Belongs to the NlpA lipoprotein family
A6J80_RS14485	COG1464	Belongs to the NlpA lipoprotein family
A6J80_RS14490	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A6J80_RS14495	COG2011	ABC-type metal ion transport system permease component
A6J80_RS14520	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
A6J80_RS14530	COG0765	amino acid transport
A6J80_RS14535	COG0765	amino acid transport
A6J80_RS14555	COG2986	histidine ammonia-lyase
A6J80_RS14560	COG1228	amidohydrolase
A6J80_RS14565	COG0402	S-adenosylhomocysteine deaminase activity
A6J80_RS14575	COG1872	DUF167
A6J80_RS14595	COG0440	acetolactate synthase activity
A6J80_RS14600	COG0028	Belongs to the TPP enzyme family
A6J80_RS14605	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
A6J80_RS14620	COG0505	Belongs to the CarA family
A6J80_RS14625	COG1610	YqeY-like protein
A6J80_RS14630	COG3454	Phosphonate metabolism
A6J80_RS14635	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A6J80_RS14650	COG0481	GTPase activity
A6J80_RS14655	COG0531	amino acid
A6J80_RS14660	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A6J80_RS14665	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A6J80_RS14670	COG0573	inorganic phosphate transmembrane transporter activity
A6J80_RS14680	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A6J80_RS14690	COG0745	RESPONSE REGULATOR receiver
A6J80_RS14700	COG0758	DNA mediated transformation
A6J80_RS14705	COG0312	modulator of DNA gyrase
A6J80_RS14715	COG0109	protoheme IX farnesyltransferase activity
A6J80_RS14725	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
A6J80_RS14745	COG0612	Peptidase, M16
A6J80_RS14770	COG0427	acetyl-CoA hydrolase
A6J80_RS14780	COG2011	ABC-type metal ion transport system permease component
A6J80_RS14785	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A6J80_RS14800	COG1785	Belongs to the alkaline phosphatase family
A6J80_RS14810	COG1136	(ABC) transporter
A6J80_RS14845	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A6J80_RS14875	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A6J80_RS14895	COG1473	amidohydrolase
A6J80_RS14900	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A6J80_RS14910	COG2814	Major facilitator Superfamily
A6J80_RS14915	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A6J80_RS14935	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A6J80_RS14940	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A6J80_RS14945	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A6J80_RS14995	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A6J80_RS15000	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A6J80_RS15005	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A6J80_RS15020	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A6J80_RS15025	COG0756	dUTP diphosphatase activity
A6J80_RS15030	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A6J80_RS15055	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A6J80_RS15075	COG3474	cytochrome
A6J80_RS15080	COG0321	lipoyl(octanoyl) transferase activity
A6J80_RS15095	COG3842	ATPase activity
A6J80_RS15115	COG1177	transmembrane transport
A6J80_RS15125	COG1234	tRNA 3'-trailer cleavage
A6J80_RS15130	COG0084	hydrolase, TatD family'
A6J80_RS15140	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A6J80_RS15145	COG1686	Belongs to the peptidase S11 family
A6J80_RS15150	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A6J80_RS15155	COG0303	'Molybdopterin
A6J80_RS15160	COG0315	cyclic pyranopterin monophosphate synthase activity
A6J80_RS15165	COG0134	indole-3-glycerol-phosphate synthase activity
A6J80_RS15170	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
A6J80_RS15175	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A6J80_RS15205	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A6J80_RS15215	COG1476	TRANSCRIPTIONal
A6J80_RS15220	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A6J80_RS15230	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
A6J80_RS15240	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A6J80_RS15245	COG0259	pyridoxamine-phosphate oxidase activity
A6J80_RS15250	COG1278	Cold shock
A6J80_RS15270	COG3750	Belongs to the UPF0335 family
A6J80_RS15285	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A6J80_RS15355	COG1278	Cold shock
A6J80_RS15385	COG2375	cellular response to nickel ion
A6J80_RS15400	COG0527	aspartate kinase activity
A6J80_RS15430	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A6J80_RS15435	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A6J80_RS15450	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A6J80_RS15460	COG0649	NAD binding
A6J80_RS15505	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
A6J80_RS15515	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A6J80_RS15530	COG0713	ATP synthesis coupled electron transport
A6J80_RS15545	COG1007	ATP synthesis coupled electron transport
A6J80_RS15555	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
A6J80_RS15565	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A6J80_RS15570	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A6J80_RS15580	COG0280	phosphate acetyltransferase
A6J80_RS15580	COG0281	malic enzyme
A6J80_RS15595	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
A6J80_RS15600	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A6J80_RS15605	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A6J80_RS15620	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A6J80_RS15625	COG0564	pseudouridine synthase activity
A6J80_RS15640	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A6J80_RS15650	COG1496	oxidoreductase activity
A6J80_RS15660	COG1522	sequence-specific DNA binding
A6J80_RS15665	COG0492	ferredoxin-NADP+ reductase activity
A6J80_RS15670	COG2046	Belongs to the sulfate adenylyltransferase family
A6J80_RS15670	COG0529	Catalyzes the synthesis of activated sulfate
A6J80_RS15695	COG0596	Alpha beta hydrolase
A6J80_RS15705	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A6J80_RS15725	COG1764	response to oxidative stress
A6J80_RS15730	COG0232	Belongs to the dGTPase family. Type 2 subfamily
A6J80_RS15750	COG4166	transmembrane transport
A6J80_RS15760	COG1028	Short-chain dehydrogenase reductase Sdr
A6J80_RS15770	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
A6J80_RS15780	COG1215	transferase activity, transferring glycosyl groups
A6J80_RS15785	COG1215	transferase activity, transferring glycosyl groups
A6J80_RS15830	COG4191	Histidine kinase
A6J80_RS15830	COG0784	Response regulator, receiver
A6J80_RS15840	COG0318	PFAM AMP-dependent synthetase and ligase
A6J80_RS15865	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
A6J80_RS15875	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A6J80_RS15885	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A6J80_RS15890	COG1063	alcohol dehydrogenase
A6J80_RS15895	COG1312	Catalyzes the dehydration of D-mannonate
A6J80_RS15900	COG0246	Mannitol dehydrogenase
A6J80_RS15905	COG0246	Mannitol dehydrogenase
A6J80_RS15910	COG1063	alcohol dehydrogenase
A6J80_RS15915	COG2721	sulfolactate sulfo-lyase activity
A6J80_RS15920	COG1609	Transcriptional regulator
A6J80_RS15925	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A6J80_RS15925	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6J80_RS15930	COG1105	Belongs to the carbohydrate kinase PfkB family
A6J80_RS15935	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A6J80_RS15935	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A6J80_RS15940	COG1301	dicarboxylic acid transport
A6J80_RS15945	COG4191	Histidine kinase
A6J80_RS15950	COG2204	response regulator
A6J80_RS15955	COG2183	response to ionizing radiation
A6J80_RS15960	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
A6J80_RS15965	COG2258	MOSC domain
A6J80_RS15970	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A6J80_RS15980	COG1780	Probably involved in ribonucleotide reductase function
A6J80_RS15985	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A6J80_RS15990	COG1252	NADH dehydrogenase
A6J80_RS16020	COG1027	Aspartate ammonia-lyase
A6J80_RS16025	COG0583	DNA-binding transcription factor activity
A6J80_RS16030	COG0523	cobalamin synthesis protein
A6J80_RS16190	COG0419	ATPase involved in DNA repair
A6J80_RS16195	COG0420	3'-5' exonuclease activity
A6J80_RS16205	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A6J80_RS16260	COG3547	Transposase (IS116 IS110 IS902 family)
A6J80_RS16280	COG3842	ATPase activity
A6J80_RS16290	COG1175	transmembrane transport
A6J80_RS16295	COG0395	ABC-type sugar transport system, permease component
A6J80_RS16305	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A6J80_RS16315	COG1028	Short-chain dehydrogenase reductase Sdr
A6J80_RS16335	COG2267	carboxylic ester hydrolase activity
A6J80_RS16340	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A6J80_RS16340	COG0473	3-isopropylmalate dehydrogenase activity
A6J80_RS16375	COG0583	DNA-binding transcription factor activity
A6J80_RS16380	COG2515	1-aminocyclopropane-1-carboxylate deaminase
A6J80_RS16385	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A6J80_RS16395	COG4521	taurine ABC transporter
A6J80_RS16400	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
A6J80_RS16405	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A6J80_RS16410	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A6J80_RS16415	COG0508	dehydrogenase complex catalyzes the overall conversion of
A6J80_RS16415	COG0596	Alpha beta hydrolase
A6J80_RS16420	COG2855	membrane
A6J80_RS16440	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A6J80_RS16450	COG1012	belongs to the aldehyde dehydrogenase family
A6J80_RS16455	COG0583	DNA-binding transcription factor activity
A6J80_RS16470	COG0789	Transcriptional regulator
A6J80_RS16510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6J80_RS16530	COG0010	Belongs to the arginase family
A6J80_RS16560	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A6J80_RS16570	COG2433	Pfam Transposase IS66
A6J80_RS16575	COG3436	PFAM IS66 Orf2 family protein
A6J80_RS16580	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A6J80_RS16690	COG0464	growth
A6J80_RS16720	COG2932	Transcriptional regulator
A6J80_RS16755	COG1061	Type III restriction enzyme res subunit
A6J80_RS16790	COG1475	DNA binding
A6J80_RS16870	COG3550	peptidyl-serine autophosphorylation
A6J80_RS16890	COG3547	Transposase (IS116 IS110 IS902 family)
A6J80_RS16900	COG1971	Probably functions as a manganese efflux pump
A6J80_RS16915	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A6J80_RS16975	COG1064	alcohol dehydrogenase
A6J80_RS17005	COG0753	catalase activity
A6J80_RS17020	COG2223	nitrite transmembrane transporter activity
A6J80_RS17035	COG1178	ABC-type Fe3 transport system permease component
A6J80_RS17045	COG3842	ATPase activity
A6J80_RS17050	COG0583	DNA-binding transcription factor activity
A6J80_RS17060	COG2814	Major facilitator Superfamily
A6J80_RS17065	COG0640	Transcriptional regulator
A6J80_RS17070	COG1230	cation diffusion facilitator family transporter
A6J80_RS17075	COG1120	ATPase activity
A6J80_RS17090	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A6J80_RS17095	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A6J80_RS17100	COG2239	Acts as a magnesium transporter
A6J80_RS17105	COG0483	inositol monophosphate 1-phosphatase activity
A6J80_RS17115	COG0604	alcohol dehydrogenase
A6J80_RS17115	COG4221	oxidoreductase activity
A6J80_RS17115	COG3321	synthase
A6J80_RS17115	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A6J80_RS17120	COG0670	Belongs to the BI1 family
A6J80_RS17135	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
A6J80_RS17540	COG4372	Transposase
A6J80_RS17545	COG3436	PFAM IS66 Orf2 family protein
A6J80_RS17550	COG2963	transposase activity
A6J80_RS17555	COG3757	hydrolase, family 25
A6J80_RS17555	COG3409	Peptidoglycan-binding domain 1 protein
A6J80_RS17570	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A6J80_RS17580	COG3956	TIGRFAM MazG family protein
A6J80_RS17585	COG1862	Preprotein translocase
A6J80_RS17590	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A6J80_RS17595	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A6J80_RS17600	COG3737	Protein of unknown function (DUF498/DUF598)
A6J80_RS17605	COG4133	protoheme IX ABC transporter activity
A6J80_RS17610	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A6J80_RS17615	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A6J80_RS17625	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A6J80_RS17630	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A6J80_RS17635	COG0287	Prephenate dehydrogenase
A6J80_RS17670	COG1247	-acetyltransferase
A6J80_RS17675	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A6J80_RS17675	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A6J80_RS17695	COG4770	biotin carboxylase activity
A6J80_RS17720	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A6J80_RS17725	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A6J80_RS17730	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A6J80_RS17735	COG1127	ABC transporter
A6J80_RS17740	COG1702	phosphate starvation-inducible protein PhoH
A6J80_RS17745	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A6J80_RS17750	COG1253	flavin adenine dinucleotide binding
A6J80_RS17755	COG0456	acetyltransferase
A6J80_RS17755	COG0454	-acetyltransferase
A6J80_RS17760	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A6J80_RS17765	COG0583	DNA-binding transcription factor activity
A6J80_RS17775	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A6J80_RS17780	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
A6J80_RS17795	COG1138	Cytochrome C-type biogenesis protein
A6J80_RS17800	COG3088	subunit of a heme lyase
A6J80_RS17805	COG1024	Enoyl-CoA hydratase
A6J80_RS17830	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A6J80_RS17835	COG2824	Alkylphosphonate utilization operon protein PhnA
A6J80_RS17840	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A6J80_RS17845	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A6J80_RS17850	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A6J80_RS17865	COG2166	iron-sulfur cluster assembly
A6J80_RS17905	COG0482	sulfurtransferase activity
A6J80_RS17980	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A6J80_RS17985	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A6J80_RS17995	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A6J80_RS18000	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A6J80_RS18005	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
A6J80_RS18010	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
A6J80_RS18030	COG0358	DNA primase activity
A6J80_RS18035	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A6J80_RS18045	COG1322	Protein conserved in bacteria
A6J80_RS18050	COG0432	Pfam Uncharacterised protein family UPF0047
A6J80_RS18060	COG1177	transmembrane transport
A6J80_RS18080	COG0215	cysteine-tRNA ligase activity
A6J80_RS18085	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A6J80_RS18095	COG0148	phosphopyruvate hydratase activity
A6J80_RS18105	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
A6J80_RS18110	COG2076	Multidrug Resistance protein
A6J80_RS18115	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A6J80_RS18120	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A6J80_RS18130	COG0308	aminopeptidase N
A6J80_RS18140	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
A6J80_RS18145	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A6J80_RS18150	COG2890	protein-(glutamine-N5) methyltransferase activity
A6J80_RS18160	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A6J80_RS18165	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
A6J80_RS18170	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A6J80_RS18175	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
A6J80_RS18185	COG0795	lipopolysaccharide-transporting ATPase activity
A6J80_RS18190	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A6J80_RS18200	COG3577	Aspartyl protease
A6J80_RS18205	COG2095	MarC family integral membrane protein
A6J80_RS18210	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A6J80_RS18220	COG0805	protein transport
A6J80_RS18235	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A6J80_RS18245	COG2860	membrane
A6J80_RS18250	COG0328	RNA-DNA hybrid ribonuclease activity
A6J80_RS18265	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
A6J80_RS18270	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A6J80_RS18300	COG1522	sequence-specific DNA binding
A6J80_RS18305	COG1280	lysine exporter protein (LysE YggA)
A6J80_RS18315	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
A6J80_RS18320	COG0181	hydroxymethylbilane synthase activity
A6J80_RS18325	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
A6J80_RS18345	COG2814	Major facilitator Superfamily
A6J80_RS18355	COG0277	FAD linked oxidase domain protein
A6J80_RS18360	COG0277	FAD linked oxidase domain protein
A6J80_RS18365	COG0247	lactate metabolic process
A6J80_RS18370	COG0071	Belongs to the small heat shock protein (HSP20) family
A6J80_RS18375	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A6J80_RS18380	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A6J80_RS18385	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A6J80_RS18395	COG0488	(ABC) transporter
A6J80_RS18410	COG1196	nuclear chromosome segregation
A6J80_RS18430	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A6J80_RS18450	COG2081	HI0933 family
A6J80_RS18455	COG2877	3-deoxy-8-phosphooctulonate synthase activity
A6J80_RS18470	COG1573	uracil-dna glycosylase
A6J80_RS18480	COG3108	Peptidase M15
A6J80_RS18490	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A6J80_RS18495	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A6J80_RS18515	COG1217	gtp-binding protein TYPA
A6J80_RS18545	COG2084	Dehydrogenase
A6J80_RS18555	COG1957	nucleoside hydrolase
A6J80_RS18565	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A6J80_RS18570	COG0750	zinc metalloprotease
A6J80_RS18575	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
A6J80_RS18585	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A6J80_RS18590	COG0233	cytoplasmic translational termination
A6J80_RS18595	COG0528	UMP kinase activity
A6J80_RS18600	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A6J80_RS18610	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
A6J80_RS18615	COG0248	Ppx GppA phosphatase
A6J80_RS18625	COG0501	Belongs to the peptidase M48B family
A6J80_RS18640	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
A6J80_RS18645	COG1612	heme a metabolic process
A6J80_RS18655	COG0352	thiamine-phosphate diphosphorylase activity
A6J80_RS18660	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A6J80_RS18660	COG0519	Catalyzes the synthesis of GMP from XMP
A6J80_RS18705	COG0798	PFAM Bile acid sodium symporter
A6J80_RS18710	COG0431	NADPH-dependent FMN reductase
A6J80_RS18740	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
A6J80_RS18750	COG1002	Type II restriction enzyme, methylase subunits
A6J80_RS18760	COG1061	Type III restriction enzyme res subunit
A6J80_RS18765	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A6J80_RS18810	COG1802	Transcriptional regulator
A6J80_RS18825	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A6J80_RS18840	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A6J80_RS18845	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A6J80_RS18850	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A6J80_RS18855	COG1414	Transcriptional regulator
A6J80_RS18860	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A6J80_RS18865	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A6J80_RS18870	COG3616	Alanine racemase, N-terminal domain
A6J80_RS18875	COG2423	ornithine cyclodeaminase activity
A6J80_RS18885	COG2351	hydroxyisourate hydrolase activity
A6J80_RS18890	COG2233	PERMEase
A6J80_RS18905	COG0583	DNA-binding transcription factor activity
A6J80_RS18915	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A6J80_RS18925	COG0402	S-adenosylhomocysteine deaminase activity
A6J80_RS18935	COG4638	Rieske (2fe-2S)
A6J80_RS18940	COG0583	DNA-binding transcription factor activity
A6J80_RS18945	COG5002	protein histidine kinase activity
A6J80_RS18955	COG0194	GDP metabolic process
A6J80_RS18965	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
A6J80_RS19000	COG0556	nucleotide-excision repair
A6J80_RS19010	COG1192	Involved in chromosome partitioning
A6J80_RS19025	COG0248	Ppx GppA phosphatase
A6J80_RS19030	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
A6J80_RS19035	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A6J80_RS19040	COG0628	permease
A6J80_RS19045	COG0442	prolyl-tRNA aminoacylation
A6J80_RS19050	COG0589	response to stress
A6J80_RS19055	COG2755	lipolytic protein G-D-S-L family
A6J80_RS19065	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A6J80_RS19085	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A6J80_RS19085	COG2111	Na H antiporter
A6J80_RS19090	COG1006	Multisubunit Na H antiporter MnhC subunit
A6J80_RS19095	COG0651	ATP synthesis coupled electron transport
A6J80_RS19100	COG1863	multisubunit Na H antiporter MnhE subunit
A6J80_RS19105	COG2212	antiporter activity
A6J80_RS19110	COG1320	monovalent cation:proton antiporter activity
A6J80_RS19115	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A6J80_RS19120	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A6J80_RS19135	COG4974	Belongs to the 'phage' integrase family
A6J80_RS19140	COG2233	PERMEase
A6J80_RS19145	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A6J80_RS19160	COG0508	dehydrogenase complex catalyzes the overall conversion of
A6J80_RS19165	COG0439	Biotin carboxylase
A6J80_RS19170	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
A6J80_RS19190	COG2252	PERMEase
A6J80_RS19200	COG3257	ureidoglycine aminohydrolase activity
A6J80_RS19205	COG1329	Transcriptional regulator
A6J80_RS19210	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
A6J80_RS19235	COG2267	carboxylic ester hydrolase activity
A6J80_RS19250	COG0187	DNA topoisomerase II activity
A6J80_RS19255	COG1742	UPF0060 membrane protein
A6J80_RS19275	COG1136	(ABC) transporter
A6J80_RS19285	COG1280	lysine exporter protein (LysE YggA)
A6J80_RS19295	COG1522	sequence-specific DNA binding
A6J80_RS19300	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A6J80_RS19330	COG4573	that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of
A6J80_RS19335	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A6J80_RS19340	COG1172	Belongs to the binding-protein-dependent transport system permease family
A6J80_RS19345	COG1129	ABC transporter
A6J80_RS19370	COG2205	protein histidine kinase activity
A6J80_RS19375	COG3938	Belongs to the proline racemase family
A6J80_RS19395	COG0446	pyridine nucleotide-disulphide oxidoreductase
A6J80_RS19395	COG1902	pentaerythritol trinitrate reductase activity
A6J80_RS19405	COG4176	ABC-type proline glycine betaine transport system permease component
A6J80_RS19410	COG0517	IMP dehydrogenase activity
A6J80_RS19410	COG4175	Glycine betaine
A6J80_RS19450	COG1177	transmembrane transport
A6J80_RS19455	COG3842	ATPase activity
A6J80_RS19470	COG0523	cobalamin synthesis protein
A6J80_RS19475	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A6J80_RS19480	COG1028	Short-chain dehydrogenase reductase Sdr
A6J80_RS19485	COG0747	negative chemotaxis
A6J80_RS19500	COG2610	gluconate transmembrane transporter activity
A6J80_RS19515	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A6J80_RS19520	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A6J80_RS19530	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A6J80_RS19540	COG0747	negative chemotaxis
A6J80_RS19550	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
A6J80_RS19555	COG1454	alcohol dehydrogenase
A6J80_RS19565	COG3395	kinase activity
A6J80_RS19590	COG1024	Enoyl-CoA hydratase
A6J80_RS19595	COG1012	belongs to the aldehyde dehydrogenase family
A6J80_RS19605	COG2814	Major facilitator Superfamily
A6J80_RS19630	COG0587	DNA-directed DNA polymerase activity
A6J80_RS19635	COG1929	Belongs to the glycerate kinase type-1 family
A6J80_RS19680	COG1802	Transcriptional regulator
A6J80_RS19685	COG1984	allophanate hydrolase subunit 2
A6J80_RS19690	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
A6J80_RS19705	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A6J80_RS19710	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
A6J80_RS19720	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A6J80_RS19760	COG1028	Short-chain dehydrogenase reductase Sdr
A6J80_RS19765	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A6J80_RS19790	COG1959	2 iron, 2 sulfur cluster binding
A6J80_RS19795	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
A6J80_RS19795	COG1618	nucleotide phosphatase activity, acting on free nucleotides
A6J80_RS19800	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A6J80_RS19805	COG2181	nitrate reductase activity
A6J80_RS19810	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
A6J80_RS19815	COG1140	nitrate reductase beta subunit
A6J80_RS19820	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
A6J80_RS19825	COG2223	nitrite transmembrane transporter activity
A6J80_RS19840	COG3794	PFAM blue (type 1) copper domain protein
A6J80_RS19905	COG0714	Associated with various cellular activities
A6J80_RS19915	COG1845	cytochrome c oxidase, subunit III
A6J80_RS19930	COG2954	triphosphatase activity
A6J80_RS19950	COG2828	Protein conserved in bacteria
A6J80_RS19955	COG0583	DNA-binding transcription factor activity
A6J80_RS19960	COG0471	metal ion transport
A6J80_RS19960	COG0490	domain, Protein
A6J80_RS20000	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A6J80_RS20005	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
A6J80_RS20010	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A6J80_RS20010	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A6J80_RS20035	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A6J80_RS20035	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A6J80_RS20040	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A6J80_RS20045	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
A6J80_RS20050	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A6J80_RS20060	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
A6J80_RS20065	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
A6J80_RS20075	COG4166	transmembrane transport
A6J80_RS20080	COG0745	RESPONSE REGULATOR receiver
A6J80_RS20090	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A6J80_RS20105	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
A6J80_RS20120	COG2759	Belongs to the formate--tetrahydrofolate ligase family
A6J80_RS20135	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
A6J80_RS20160	COG0493	'glutamate synthase
A6J80_RS20160	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
A6J80_RS20215	COG5442	Flagellar protein FlaF
A6J80_RS20245	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
A6J80_RS20265	COG0454	-acetyltransferase
A6J80_RS20285	COG4208	sulfate ABC transporter
A6J80_RS20290	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
A6J80_RS20305	COG4948	Mandelate Racemase Muconate Lactonizing
A6J80_RS20310	COG3485	protocatechuate 3,4-dioxygenase
A6J80_RS20345	COG0673	inositol 2-dehydrogenase activity
A6J80_RS20360	COG1260	myo-inositol-1-phosphate synthase
A6J80_RS20370	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A6J80_RS20385	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A6J80_RS20435	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A6J80_RS20440	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A6J80_RS20445	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
A6J80_RS20450	COG1028	Short-chain dehydrogenase reductase Sdr
A6J80_RS20460	COG1802	Transcriptional regulator
A6J80_RS20465	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A6J80_RS20470	COG1574	metal-dependent hydrolase with the TIM-barrel fold
A6J80_RS20515	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A6J80_RS20535	COG0765	amino acid transport
A6J80_RS20540	COG0765	amino acid transport
A6J80_RS20550	COG1396	sequence-specific DNA binding
A6J80_RS20550	COG1917	Cupin 2, conserved barrel domain protein
A6J80_RS20560	COG2301	Belongs to the HpcH HpaI aldolase family
A6J80_RS20565	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
A6J80_RS20575	COG1960	acyl-CoA dehydrogenase activity
A6J80_RS20590	COG0129	dihydroxy-acid dehydratase activity
A6J80_RS20595	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A6J80_RS20605	COG0683	leucine binding
A6J80_RS20625	COG1012	belongs to the aldehyde dehydrogenase family
A6J80_RS20630	COG0583	DNA-binding transcription factor activity
A6J80_RS20635	COG2084	Dehydrogenase
A6J80_RS20650	COG3685	Protein conserved in bacteria
A6J80_RS20660	COG1363	Peptidase, m42
A6J80_RS20665	COG2070	2-Nitropropane dioxygenase
A6J80_RS20680	COG1802	Transcriptional regulator
A6J80_RS20690	COG1175	transmembrane transport
A6J80_RS20700	COG3976	FMN-binding domain protein
A6J80_RS20700	COG1053	succinate dehydrogenase
A6J80_RS20710	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
A6J80_RS20720	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A6J80_RS20725	COG2233	PERMEase
A6J80_RS20735	COG0583	DNA-binding transcription factor activity
A6J80_RS20755	COG2828	Protein conserved in bacteria
A6J80_RS20760	COG0625	glutathione transferase activity
A6J80_RS20765	COG2079	MmgE PrpD family protein
A6J80_RS20770	COG2079	MmgE PrpD family protein
A6J80_RS20780	COG1126	abc transporter atp-binding protein
A6J80_RS20785	COG0765	amino acid transport
A6J80_RS20790	COG4597	amino acid ABC transporter
A6J80_RS20795	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6J80_RS20800	COG0626	cystathionine gamma-synthase activity
A6J80_RS20815	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6J80_RS20815	COG3453	Protein conserved in bacteria
A6J80_RS20825	COG1473	amidohydrolase
A6J80_RS20830	COG0747	negative chemotaxis
A6J80_RS20835	COG1802	Transcriptional regulator
A6J80_RS20865	COG0626	cystathionine gamma-synthase activity
A6J80_RS20880	COG0601	transmembrane transport
A6J80_RS20890	COG2002	toxin-antitoxin pair type II binding
A6J80_RS20895	COG1192	Involved in chromosome partitioning
A6J80_RS20900	COG1475	DNA binding
A6J80_RS20905	COG0640	Transcriptional regulator
A6J80_RS20910	COG1309	transcriptional regulator
A6J80_RS20935	COG0559	Belongs to the binding-protein-dependent transport system permease family
A6J80_RS20970	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A6J80_RS20995	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A6J80_RS21030	COG2124	cytochrome p450
A6J80_RS21035	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A6J80_RS21040	COG2217	Heavy metal translocating P-type atpase
A6J80_RS21045	COG0789	Transcriptional regulator
A6J80_RS21050	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A6J80_RS21050	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A6J80_RS21090	COG3034	peptidoglycan biosynthetic process
A6J80_RS21100	COG1999	signal sequence binding
A6J80_RS21110	COG1999	signal sequence binding
A6J80_RS21115	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A6J80_RS21115	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A6J80_RS21130	COG0789	Transcriptional regulator
A6J80_RS21150	COG1321	iron dependent repressor
A6J80_RS21155	COG1914	H( )-stimulated, divalent metal cation uptake system
A6J80_RS21180	COG2963	transposase activity
A6J80_RS21185	COG3436	PFAM IS66 Orf2 family protein
A6J80_RS21190	COG4372	Transposase
A6J80_RS21195	COG0071	Belongs to the small heat shock protein (HSP20) family
A6J80_RS21200	COG0071	Belongs to the small heat shock protein (HSP20) family
A6J80_RS21230	COG3547	Transposase (IS116 IS110 IS902 family)
A6J80_RS21240	COG3547	Transposase (IS116 IS110 IS902 family)
A6J80_RS21250	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6J80_RS21255	COG0842	Transport permease protein
A6J80_RS21255	COG1129	ABC transporter
A6J80_RS21260	COG0842	Transport permease protein
A6J80_RS21275	COG0280	phosphate acetyltransferase
A6J80_RS21280	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A6J80_RS21285	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A6J80_RS21335	COG3742	Toxic component of a toxin-antitoxin (TA) module. An RNase
A6J80_RS21360	COG1752	Esterase of the alpha-beta hydrolase superfamily
A6J80_RS21365	COG2801	Transposase and inactivated derivatives
A6J80_RS21400	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A6J80_RS21405	COG1192	Involved in chromosome partitioning
A6J80_RS21425	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
A6J80_RS21445	COG1172	Belongs to the binding-protein-dependent transport system permease family
A6J80_RS21450	COG1129	ABC transporter
A6J80_RS21455	COG1012	belongs to the aldehyde dehydrogenase family
A6J80_RS21485	COG0673	inositol 2-dehydrogenase activity
A6J80_RS21500	COG2963	transposase activity
A6J80_RS21510	COG4372	Transposase
A6J80_RS21515	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A6J80_RS21520	COG2207	Transcriptional regulator
A6J80_RS21575	COG3181	Tripartite tricarboxylate transporter family receptor
A6J80_RS21600	COG2963	transposase activity
A6J80_RS21605	COG3436	PFAM IS66 Orf2 family protein
A6J80_RS21610	COG4372	Transposase
A6J80_RS21660	COG3077	Addiction module antitoxin, RelB DinJ family
A6J80_RS21665	COG3505	Type IV secretory pathway VirD4
A6J80_RS21690	COG3704	protein secretion by the type IV secretion system
A6J80_RS21705	COG1196	nuclear chromosome segregation
A6J80_RS21705	COG0739	heme binding
A6J80_RS21705	COG0741	lytic transglycosylase activity
A6J80_RS21710	COG3451	type IV secretory pathway VirB4
A6J80_RS21730	COG3916	Acyl-homoserine-lactone synthase
A6J80_RS21795	COG3318	Belongs to the UPF0149 family
A6J80_RS21795	COG3012	SEC-C Motif Domain Protein
A6J80_RS21805	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A6J80_RS21810	COG0251	oxidation-reduction process
A6J80_RS21815	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A6J80_RS21815	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A6J80_RS21830	COG0438	transferase activity, transferring glycosyl groups
A6J80_RS21850	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A6J80_RS21855	COG1126	abc transporter atp-binding protein
A6J80_RS21865	COG0765	amino acid transport
A6J80_RS21870	COG0765	amino acid transport
A6J80_RS21875	COG3473	Maleate cis-trans isomerase
A6J80_RS21880	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A6J80_RS21885	COG2423	ornithine cyclodeaminase activity
A6J80_RS21890	COG0006	proline dipeptidase activity
A6J80_RS21895	COG3608	succinylglutamate desuccinylase aspartoacylase
A6J80_RS21900	COG1012	belongs to the aldehyde dehydrogenase family
A6J80_RS21905	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A6J80_RS21930	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
A6J80_RS21935	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
A6J80_RS21990	COG3391	amine dehydrogenase activity
A6J80_RS21995	COG2259	Doxx family
A6J80_RS22000	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A6J80_RS22010	COG3794	PFAM blue (type 1) copper domain protein
A6J80_RS22020	COG1858	cytochrome C peroxidase
A6J80_RS22025	COG0437	4 iron, 4 sulfur cluster binding
A6J80_RS22030	COG0348	domain, Protein
A6J80_RS22040	COG1304	FMN binding
A6J80_RS22080	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
A6J80_RS22080	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
A6J80_RS22085	COG3831	ATPase activity
A6J80_RS22090	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
A6J80_RS22095	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6J80_RS22100	COG4771	TonB-dependent receptor
A6J80_RS22110	COG1028	Short-chain dehydrogenase reductase Sdr
A6J80_RS22120	COG1960	acyl-CoA dehydrogenase activity
A6J80_RS22125	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A6J80_RS22140	COG1024	Enoyl-CoA hydratase
A6J80_RS22145	COG0318	PFAM AMP-dependent synthetase and ligase
A6J80_RS22210	COG3254	rhamnose metabolic process
A6J80_RS22220	COG1172	Belongs to the binding-protein-dependent transport system permease family
A6J80_RS22230	COG1879	ABC-type sugar transport system periplasmic component
A6J80_RS22235	COG1349	DNA-binding transcription factor activity
A6J80_RS22240	COG3347	Dehydrogenase
A6J80_RS22240	COG1028	Short-chain dehydrogenase reductase Sdr
A6J80_RS22245	COG4952	isomerase
A6J80_RS22260	COG1175	transmembrane transport
A6J80_RS22275	COG1063	alcohol dehydrogenase
A6J80_RS22280	COG3842	ATPase activity
A6J80_RS22285	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A6J80_RS22290	COG1028	Short-chain dehydrogenase reductase Sdr
A6J80_RS22305	COG1192	Involved in chromosome partitioning
A6J80_RS22320	COG3246	L-lysine catabolic process to acetate
A6J80_RS22325	COG0824	Thioesterase
A6J80_RS22325	COG1250	3-hydroxyacyl-CoA dehydrogenase
A6J80_RS22375	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
A6J80_RS22390	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A6J80_RS22395	COG0697	spore germination
A6J80_RS22410	COG0287	Prephenate dehydrogenase
A6J80_RS22475	COG1116	anion transmembrane transporter activity
A6J80_RS22480	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A6J80_RS22495	COG0784	Response regulator, receiver
A6J80_RS22495	COG4191	Histidine kinase
A6J80_RS22535	COG1388	LysM domain
A6J80_RS22535	COG1376	ErfK ybiS ycfS ynhG family protein
A6J80_RS22570	COG2132	Multicopper oxidase
A6J80_RS22575	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A6J80_RS22580	COG3436	PFAM IS66 Orf2 family protein
A6J80_RS22585	COG2963	transposase activity
A6J80_RS22595	COG1216	Glycosyl transferase, family 2
A6J80_RS22610	COG1091	dTDP-4-dehydrorhamnose reductase activity
A6J80_RS22630	COG1192	Involved in chromosome partitioning
A6J80_RS22665	COG1215	transferase activity, transferring glycosyl groups
A6J80_RS22685	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A6J80_RS22695	COG3609	addiction module antidote protein, CC2985 family
A6J80_RS22780	COG1414	Transcriptional regulator
A6J80_RS22785	COG1475	DNA binding
A6J80_RS22790	COG1192	Involved in chromosome partitioning
A6J80_RS22795	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A6J80_RS22810	COG3794	PFAM blue (type 1) copper domain protein
A6J80_RS22900	COG3012	SEC-C Motif Domain Protein
A6J80_RS22915	COG0071	Belongs to the small heat shock protein (HSP20) family
A6J80_RS22920	COG0071	Belongs to the small heat shock protein (HSP20) family
A6J80_RS22930	COG1846	Transcriptional regulator
A6J80_RS22940	COG0542	response to heat
A6J80_RS22980	COG3118	belongs to the thioredoxin family
A6J80_RS22995	COG3436	PFAM IS66 Orf2 family protein
A6J80_RS23000	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A6J80_RS23010	COG2433	Pfam Transposase IS66
A6J80_RS23100	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
A6J80_RS23110	COG1879	ABC-type sugar transport system periplasmic component
A6J80_RS23130	COG4175	Glycine betaine
A6J80_RS23135	COG4176	ABC-type proline glycine betaine transport system permease component
A6J80_RS23205	COG2233	PERMEase
A6J80_RS23210	COG1335	isochorismatase
A6J80_RS23215	COG2309	aminopeptidase activity
A6J80_RS23225	COG3473	Maleate cis-trans isomerase
A6J80_RS23235	COG1846	Transcriptional regulator
A6J80_RS23240	COG0477	Major facilitator Superfamily
A6J80_RS23245	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A6J80_RS23250	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A6J80_RS23250	COG2010	Cytochrome c
A6J80_RS23255	COG2080	2 iron, 2 sulfur cluster binding
A6J80_RS23295	COG3505	Type IV secretory pathway VirD4
A6J80_RS23350	COG3742	Toxic component of a toxin-antitoxin (TA) module. An RNase
A6J80_RS23365	COG3547	Transposase (IS116 IS110 IS902 family)
A6J80_RS23440	COG3459	Glycosyltransferase 36 associated