locus-tag class description D3H65_RS00005 ENOG4107ZT5 Thiol disulfide interchange protein D3H65_RS00010 ENOG4108NEV two component transcriptional regulator, LytTR family D3H65_RS00015 ENOG4108HRK Histidine kinase D3H65_RS00035 ENOG41080ZE Adenylate cyclase D3H65_RS00040 ENOG4105CQB FAD linked oxidase domain protein D3H65_RS00045 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein D3H65_RS00085 ENOG41082BM Transcriptional regulator, arsr family D3H65_RS00090 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS00110 ENOG4105D63 family UPF0324 D3H65_RS00120 ENOG4108HRK Histidine kinase D3H65_RS00125 ENOG4105DY9 regulatoR D3H65_RS00145 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) D3H65_RS00150 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) D3H65_RS00180 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) D3H65_RS00185 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family D3H65_RS00200 ENOG4108ZHR arsR family transcriptional regulator D3H65_RS00205 ENOG4108RG3 short-chain dehydrogenase reductase D3H65_RS00210 ENOG4105EE0 oxidoreductase D3H65_RS00215 ENOG4105QNR S1 RNA binding domain protein D3H65_RS00220 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) D3H65_RS00255 ENOG4107YHX fad dependent oxidoreductase D3H65_RS00265 ENOG4108HRK Histidine kinase D3H65_RS00275 ENOG4105DY9 regulatoR D3H65_RS00285 ENOG4105F6U Short-chain dehydrogenase reductase Sdr D3H65_RS00290 ENOG4105KVH Transcriptional regulator D3H65_RS00325 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase D3H65_RS00335 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) D3H65_RS00365 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) D3H65_RS00375 ENOG4107VXZ Hydrolase D3H65_RS00415 ENOG4105BZU Histidine kinase D3H65_RS00420 ENOG4107R4J Chloride channel D3H65_RS00425 ENOG4105WH1 Two component transcriptional regulator luxr family D3H65_RS00470 ENOG4108IFH alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen D3H65_RS00500 ENOG4106BQ7 Glycosyl Transferase D3H65_RS00505 ENOG4105BZU Histidine kinase D3H65_RS00560 ENOG4105NCT RNA Polymerase D3H65_RS00570 ENOG4105D6J arsenicaL-resistance protein D3H65_RS00575 ENOG41089UC methyltransferase, type 11 D3H65_RS00585 ENOG4105DY9 regulatoR D3H65_RS00605 ENOG41087PP glycosyltransferase MGT family D3H65_RS00620 ENOG4105ENT Efflux transporter rnd family, mfp subunit D3H65_RS00660 ENOG4105C0B DNA polymerase III (alpha subunit) D3H65_RS00680 ENOG4105VEQ Cold shock protein D3H65_RS00685 ENOG4105VFU Rna-binding protein D3H65_RS00690 ENOG4108YRB methyltransferase D3H65_RS00695 ENOG4108K2B transcriptional regulator D3H65_RS00740 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) D3H65_RS00745 ENOG4107QRI Phosphoketolase D3H65_RS00755 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme D3H65_RS00785 ENOG4108KAZ Involved in phosphonate degradation (By similarity) D3H65_RS00800 ENOG4105E98 transcriptional regulator DeoR family D3H65_RS00820 ENOG4105C6Z Gluconate D3H65_RS00900 ENOG4105JXH GntR family transcriptional regulator D3H65_RS00935 ENOG4108478 ec 3.2.1.18 D3H65_RS00940 ENOG4108478 ec 3.2.1.18 D3H65_RS00950 ENOG4107RJ1 sodium solute D3H65_RS01015 ENOG4105DY9 regulatoR D3H65_RS01030 ENOG4105DXN mazG family D3H65_RS01065 ENOG4105CA0 peroxidase D3H65_RS01090 ENOG4105DFH Transport of potassium into the cell (By similarity) D3H65_RS01100 ENOG4105C59 p-type ATPase D3H65_RS01110 ENOG4105ID8 Transcriptional regulator, ARAC family D3H65_RS01185 ENOG4107QWP ABC-2 type transporter D3H65_RS01190 ENOG4105D0S secretion protein (HlyD D3H65_RS01200 ENOG4107QPK )-transporter D3H65_RS01210 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) D3H65_RS01230 ENOG4105MHT Transcriptional regulator, ARSR family D3H65_RS01255 ENOG4105CEV competence damage-inducible protein D3H65_RS01270 ENOG4105BZU Histidine kinase D3H65_RS01275 ENOG4105BZU Histidine kinase D3H65_RS01280 ENOG4105E09 nadh pyrophosphatase D3H65_RS01295 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) D3H65_RS01300 ENOG4105D3A purine nucleoside phosphorylase DeoD-type D3H65_RS01315 ENOG4105C4R Atp-dependent dna helicase D3H65_RS01320 ENOG4108JEH abc transporter atp-binding protein D3H65_RS01375 ENOG4105QE3 oxidoreductase D3H65_RS01405 ENOG4105WEF catalase D3H65_RS01410 ENOG4105T58 Dithiol-disulfide isomerase D3H65_RS01420 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) D3H65_RS01455 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone D3H65_RS01460 ENOG4105CG3 alpha amylase, catalytic region D3H65_RS01470 ENOG4108Z9Z response to DNA damage stimulus D3H65_RS01475 ENOG4105CYX Short-chain dehydrogenase reductase Sdr D3H65_RS01485 ENOG4108ZHJ Organic hydroperoxide resistance protein D3H65_RS01495 ENOG4105CIR epoxide hydrolase D3H65_RS01500 ENOG4105E1F short-chain dehydrogenase reductase D3H65_RS01525 ENOG4108HKT sucrose-6-phosphate hydrolase D3H65_RS01570 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) D3H65_RS01630 ENOG4107RBB ABC transporter, permease D3H65_RS01635 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) D3H65_RS01640 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase D3H65_RS01645 ENOG4105C5Z peptidase D3H65_RS01660 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS01675 ENOG4105HY2 Glycosidase related protein D3H65_RS01690 ENOG4105CZ9 Domain of unknown function (DU1801) D3H65_RS01710 ENOG41082BM Transcriptional regulator, arsr family D3H65_RS01755 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr D3H65_RS01760 ENOG4105E5M Multidrug resistance protein D D3H65_RS01765 ENOG4108KDQ Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons (By similarity) D3H65_RS01820 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS01840 ENOG4105C31 Tryptophanyl-tRNA synthetase D3H65_RS01845 ENOG4108Z12 YiaAB two helix domain-containing protein D3H65_RS01865 ENOG4105C8Y Acetylornithine aminotransferase D3H65_RS01870 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) D3H65_RS01880 ENOG4105C10 Electron transfer flavoprotein D3H65_RS01895 ENOG4107THF Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) D3H65_RS01905 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) D3H65_RS01910 ENOG4105DSF transport protein D3H65_RS01945 ENOG4105VWP Inherit from COG: 4Fe-4S ferredoxin, iron-sulfur binding D3H65_RS01950 ENOG4105ENA helicase D3H65_RS01975 ENOG4105BZU Histidine kinase D3H65_RS01985 ENOG4105DDI hemolysin-type calcium-binding region D3H65_RS02020 ENOG4105I82 acetyl xylan esterase D3H65_RS02055 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) D3H65_RS02060 ENOG4105CYP glycoside hydrolase, family D3H65_RS02080 ENOG4105ECQ AraC Family Transcriptional Regulator D3H65_RS02090 ENOG4105CZQ inner membrane transport protein YdhC D3H65_RS02120 ENOG4108NEV two component transcriptional regulator, LytTR family D3H65_RS02125 ENOG4108HRK Histidine kinase D3H65_RS02185 ENOG4108HRK Histidine kinase D3H65_RS02190 ENOG4108NEV two component transcriptional regulator, LytTR family D3H65_RS02195 ENOG4107ZT5 Thiol disulfide interchange protein D3H65_RS02200 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) D3H65_RS02215 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS02225 ENOG4105D44 asparaginase D3H65_RS02230 ENOG4105BZ1 (ABC) transporter D3H65_RS02240 ENOG4105BZU Histidine kinase D3H65_RS02255 ENOG4108KPJ rna polymerase sigma factor D3H65_RS02260 ENOG4105DY9 regulatoR D3H65_RS02265 ENOG4108HRK Histidine kinase D3H65_RS02285 ENOG4105DQE DNA ligase D3H65_RS02295 ENOG4105WKW Pfam:DUF1458 D3H65_RS02315 ENOG4105F27 Major Facilitator D3H65_RS02340 ENOG4105DY9 regulatoR D3H65_RS02345 ENOG4108HRK Histidine kinase D3H65_RS02370 ENOG4105WH1 Two component transcriptional regulator luxr family D3H65_RS02385 ENOG4105CPC Aldo Keto reductase D3H65_RS02395 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) D3H65_RS02410 ENOG4105K63 Thioredoxin D3H65_RS02440 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) D3H65_RS02500 ENOG4105CHR reductase D3H65_RS02505 ENOG4105ERH Fumarylacetoacetate hydrolase D3H65_RS02510 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) D3H65_RS02515 ENOG4107QR9 Iron-sulfur cluster binding protein D3H65_RS02520 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) D3H65_RS02525 ENOG4105CHR reductase D3H65_RS02530 ENOG4105EDR glucose galactose transporter D3H65_RS02540 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS02555 ENOG4105CNT hydrolase family 2 D3H65_RS02585 ENOG4105EP8 Glycosyl Hydrolase Family 88 D3H65_RS02595 ENOG4107QWG 2-Nitropropane dioxygenase D3H65_RS02640 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS02675 ENOG4105VEQ Cold shock protein D3H65_RS02680 ENOG4107VIJ nudix hydrolase D3H65_RS02690 ENOG4108HRK Histidine kinase D3H65_RS02700 ENOG4105ETE Transcriptional regulator (LacI family D3H65_RS02770 ENOG4105FTV AraC Family Transcriptional Regulator D3H65_RS02780 ENOG4105CTX dehydratase D3H65_RS02785 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) D3H65_RS02795 ENOG4105C6F GntR Family Transcriptional Regulator D3H65_RS02800 ENOG4105EU0 Major facilitator Superfamily D3H65_RS02805 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) D3H65_RS02830 ENOG4108MR6 WD40-like Beta Propeller Repeat D3H65_RS02835 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) D3H65_RS02840 ENOG4105E2D ec 3.2.1.52 D3H65_RS02870 ENOG4106N3A copper homeostasis protein cutc D3H65_RS02900 ENOG4105CTQ phosphohexokinase D3H65_RS02910 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase D3H65_RS02935 ENOG4105CEU Arginine dihydrolase D3H65_RS02940 ENOG4108Z9K Osmotically inducible protein D3H65_RS02960 ENOG4105VFU Rna-binding protein D3H65_RS02990 ENOG4105CNT hydrolase family 2 D3H65_RS03010 ENOG4105EPC oxidoreductase D3H65_RS03040 ENOG4105KWI UPF0339 protein D3H65_RS03065 ENOG4105ENT Efflux transporter rnd family, mfp subunit D3H65_RS03085 ENOG4108IJ0 Aspartate ammonia-lyase D3H65_RS03090 ENOG4105BZU Histidine kinase D3H65_RS03095 ENOG41082W1 Cupin 2, conserved barrel domain protein D3H65_RS03115 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) D3H65_RS03120 ENOG4105VIE preprotein translocase, subunit YajC D3H65_RS03130 ENOG4107R6T Involved in the transcription termination process (By similarity) D3H65_RS03135 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) D3H65_RS03155 ENOG4105VN1 Heat shock protein D3H65_RS03160 ENOG4108Y6J UPF0403 protein D3H65_RS03165 ENOG4107SYZ Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) D3H65_RS03180 ENOG4108VPT UPF0234 protein D3H65_RS03185 ENOG41081WG 50s ribosomal protein l31 D3H65_RS03195 ENOG4105CP7 Triose-phosphate isomerase D3H65_RS03220 ENOG4105CYW agmatinase D3H65_RS03230 ENOG4105DA4 cytochrome c-type biogenesis protein D3H65_RS03240 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) D3H65_RS03250 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) D3H65_RS03255 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) D3H65_RS03260 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) D3H65_RS03270 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP D3H65_RS03280 ENOG4105C2N RNA methyltransferase TrmH family group 3 D3H65_RS03285 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B D3H65_RS03305 ENOG4105EPC oxidoreductase D3H65_RS03310 ENOG4105C75 arginyL-tRNA synthetase D3H65_RS03330 ENOG4105CFG Acts as a chaperone (By similarity) D3H65_RS03340 ENOG4107RBB ABC transporter, permease D3H65_RS03345 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) D3H65_RS03365 ENOG4107R7I amino acid D3H65_RS03390 ENOG4108V1T peptidylprolyl cis-trans isomerase D3H65_RS03395 ENOG4105EJQ L-serine dehydratase D3H65_RS03410 ENOG4105DVY radical SAM domain protein D3H65_RS03415 ENOG4105D9N nucleoside D3H65_RS03435 ENOG4105C0B DNA polymerase III (alpha subunit) D3H65_RS03440 ENOG4108QBX (LipO)protein D3H65_RS03465 ENOG4105DEF Extracellular solute-binding protein, family 5 D3H65_RS03470 ENOG4105EBM Alpha Beta Hydrolase Fold protein D3H65_RS03475 ENOG4105DY9 regulatoR D3H65_RS03510 ENOG4108ZJ4 polysaccharide deacetylase D3H65_RS03520 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS03535 ENOG4105EP8 Glycosyl Hydrolase Family 88 D3H65_RS03555 ENOG4107V8H Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) D3H65_RS03560 ENOG4105C98 muts2 protein D3H65_RS03590 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) D3H65_RS03595 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) D3H65_RS03620 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS03675 ENOG4105E2D ec 3.2.1.52 D3H65_RS03680 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) D3H65_RS03690 ENOG4108JQ1 Dehydrogenase D3H65_RS03695 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) D3H65_RS03710 ENOG4105C3F Signal peptidase i D3H65_RS03715 ENOG4105KG3 cytidine deaminase D3H65_RS03735 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS03795 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) D3H65_RS03815 ENOG4108YYS metal-dependent hydrolase (By similarity) D3H65_RS03840 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) D3H65_RS03865 ENOG4105CHC glucokinase (EC 2.7.1.2) D3H65_RS03870 ENOG4105CN1 protease D3H65_RS03885 ENOG410874W AraC family transcriptional regulator D3H65_RS03945 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) D3H65_RS03970 ENOG4105ECQ AraC Family Transcriptional Regulator D3H65_RS04055 ENOG4105CVJ phosphoglycerate mutase D3H65_RS04060 ENOG4105ED2 Beta-lactamase D3H65_RS04105 ENOG4105EXC Acyl-transferase D3H65_RS04110 ENOG4108AEY RNA polymerase sigma factor D3H65_RS04120 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS04125 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS04180 ENOG4105C7R Atpase associated with various cellular activities aaa_3 D3H65_RS04215 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS04335 ENOG4108HRK Histidine kinase D3H65_RS04365 ENOG4105F2M alpha beta hydrolase fold-3 domain protein D3H65_RS04395 ENOG4105DYS nad(p)h dehydrogenase (quinone) D3H65_RS04415 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family D3H65_RS04460 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) D3H65_RS04480 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS04500 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) D3H65_RS04525 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) D3H65_RS04535 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation D3H65_RS04540 ENOG4108NEV two component transcriptional regulator, LytTR family D3H65_RS04545 ENOG4108HRK Histidine kinase D3H65_RS04590 ENOG4108NEV two component transcriptional regulator, LytTR family D3H65_RS04600 ENOG4105CIR epoxide hydrolase D3H65_RS04645 ENOG4105CVM Molybdenum cofactor synthesis domain protein D3H65_RS04660 ENOG4108ZAF Molybdopterin D3H65_RS04665 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) D3H65_RS04670 ENOG4105BZU Histidine kinase D3H65_RS04680 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS04720 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) D3H65_RS04725 ENOG4107RNU major facilitator superfamily MFS_1 D3H65_RS04735 ENOG4107QZF nitrite reductase NADPH large subunit D3H65_RS04740 ENOG4107QZF nitrite reductase NADPH large subunit D3H65_RS04745 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) D3H65_RS04760 ENOG4108NEV two component transcriptional regulator, LytTR family D3H65_RS04800 ENOG4106UW1 Major Facilitator superfamily D3H65_RS04810 ENOG4105CK6 Two component transcriptional regulator (Winged helix family D3H65_RS04815 ENOG4105GR3 Histidine kinase D3H65_RS04830 ENOG4105D64 Mechanosensitive ion channel D3H65_RS04840 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) D3H65_RS04850 ENOG4105T38 integral membrane protein D3H65_RS04855 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family D3H65_RS04905 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS04910 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS04980 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) D3H65_RS05000 ENOG4105FQP Beta-lactamase D3H65_RS05010 ENOG4105CAY ferredoxin--nadp reductase D3H65_RS05025 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA D3H65_RS05040 ENOG4105EMN RNA polymerase sigma factor D3H65_RS05055 ENOG4105CPN adenine deaminase D3H65_RS05065 ENOG4105C0B DNA polymerase III (alpha subunit) D3H65_RS05095 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase D3H65_RS05115 ENOG4105C1G acyl-Coa dehydrogenase D3H65_RS05120 ENOG4105DFA alanine racemase domain protein D3H65_RS05135 ENOG4108NEV two component transcriptional regulator, LytTR family D3H65_RS05140 ENOG4105CX6 glutaminyL-tRNA synthetase D3H65_RS05150 ENOG4105CH2 amidohydrolase D3H65_RS05170 ENOG4108YX9 iron--sulfur cluster insertion protein erpA D3H65_RS05195 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) D3H65_RS05200 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) D3H65_RS05225 ENOG4107Z5C methylesterase D3H65_RS05230 ENOG4105BZU Histidine kinase D3H65_RS05235 ENOG4105BZU Histidine kinase D3H65_RS05240 ENOG4105BZU Histidine kinase D3H65_RS05255 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) D3H65_RS05275 ENOG4107SMB hydrolase Family 5 D3H65_RS05280 ENOG4108V1T peptidylprolyl cis-trans isomerase D3H65_RS05300 ENOG4105C2I pirin domain protein D3H65_RS05305 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS05365 ENOG4106AM8 polysaccharide lyase family 8 D3H65_RS05385 ENOG4105ETE Transcriptional regulator (LacI family D3H65_RS05390 ENOG4105EP8 Glycosyl Hydrolase Family 88 D3H65_RS05395 ENOG4105ETE Transcriptional regulator (LacI family D3H65_RS05405 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen D3H65_RS05415 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS05460 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) D3H65_RS05470 ENOG4105EMN RNA polymerase sigma factor D3H65_RS05480 ENOG41068KF Universal stress protein D3H65_RS05495 ENOG4105HSS phospholipase C D3H65_RS05500 ENOG4105EW9 transcriptional regulator AsnC family D3H65_RS05505 ENOG4105FR1 rard protein D3H65_RS05515 ENOG4105DBE peroxidase D3H65_RS05555 ENOG4105DWV Homoserine O-trans-acetylase D3H65_RS05575 ENOG4105NAE bifunctional deaminase-reductase domain protein D3H65_RS05610 ENOG4105WH1 Two component transcriptional regulator luxr family D3H65_RS05620 ENOG4105ETE Transcriptional regulator (LacI family D3H65_RS05645 ENOG41075H3 AraC family transcriptional regulator D3H65_RS05720 ENOG4108S4H thioesterase Superfamily protein D3H65_RS05735 ENOG4105F32 YngK protein D3H65_RS05775 ENOG4105ECQ AraC Family Transcriptional Regulator D3H65_RS05810 ENOG4107RUZ Sss sodium solute transporter superfamily D3H65_RS05845 ENOG4105DME alpha-galactosidase D3H65_RS05850 ENOG4105CI2 imidazolone-5-propionate hydrolase D3H65_RS05900 ENOG4105CJ1 ABC, transporter D3H65_RS05905 ENOG4108HRK Histidine kinase D3H65_RS05910 ENOG4105DY9 regulatoR D3H65_RS05920 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen D3H65_RS05955 ENOG4108KBJ Inner membrane protein YkgB D3H65_RS06005 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) D3H65_RS06015 ENOG4105KVH Transcriptional regulator D3H65_RS06020 ENOG4108HRK Histidine kinase D3H65_RS06050 ENOG4107TTA Xylose isomerase domain protein TIM barrel D3H65_RS06080 ENOG4105FQP Beta-lactamase D3H65_RS06220 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS06225 ENOG4105TT1 Ragb susd domain-containing protein D3H65_RS06235 ENOG4107QWR cellulase (EC 3.2.1.4) D3H65_RS06245 ENOG4105CGS Alpha-glucosidase D3H65_RS06315 ENOG4107QRT dEAD DEAH box helicase D3H65_RS06345 ENOG41088CQ domain protein D3H65_RS06370 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS06460 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) D3H65_RS06490 ENOG4105CHR reductase D3H65_RS06505 ENOG4105CHR reductase D3H65_RS06545 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS06560 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) D3H65_RS06565 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 D3H65_RS06590 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) D3H65_RS06610 ENOG4108M8W Monooxygenase D3H65_RS06620 ENOG4105EHZ conserved protein UCP016719 D3H65_RS06635 ENOG4105CUB amino acid D3H65_RS06660 ENOG4105DT9 hydrolase family 43 D3H65_RS06685 ENOG4105IBP Cyclic peptide transporter D3H65_RS06775 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS06810 ENOG4105DA5 (ABC) transporter D3H65_RS06820 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) D3H65_RS06825 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) D3H65_RS06835 ENOG4108IFH alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen D3H65_RS06850 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) D3H65_RS06885 ENOG4105KY5 gCN5-related N-acetyltransferase D3H65_RS06955 ENOG4105CMQ Chloride channel D3H65_RS06975 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) D3H65_RS06995 ENOG4108MCI Transcriptional regulator, ARAC family D3H65_RS07000 ENOG4105C93 Xylose Isomerase D3H65_RS07005 ENOG4105DT9 hydrolase family 43 D3H65_RS07020 ENOG4105FQP Beta-lactamase D3H65_RS07025 ENOG4105E1F short-chain dehydrogenase reductase D3H65_RS07030 ENOG4105ECQ AraC Family Transcriptional Regulator D3H65_RS07045 ENOG4105F73 Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) D3H65_RS07100 ENOG4105BZ1 (ABC) transporter D3H65_RS07115 ENOG4107QP8 phosphohexose isomerase D3H65_RS07135 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase D3H65_RS07155 ENOG4105DY9 regulatoR D3H65_RS07160 ENOG4108HRK Histidine kinase D3H65_RS07165 ENOG4108HRK Histidine kinase D3H65_RS07175 ENOG4105CDV Ompa motb domain protein D3H65_RS07190 ENOG4105DY9 regulatoR D3H65_RS07200 ENOG4105DR5 peptidase D3H65_RS07315 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) D3H65_RS07345 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) D3H65_RS07355 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) D3H65_RS07385 ENOG4105DY9 regulatoR D3H65_RS07395 ENOG4105ETX regulatoR D3H65_RS07400 ENOG4105GR3 Histidine kinase D3H65_RS07410 ENOG4105FFC UPF0187 protein D3H65_RS07430 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) D3H65_RS07465 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family D3H65_RS07480 ENOG4105CPP Dehydrogenase, E1 component D3H65_RS07490 ENOG4108NEV two component transcriptional regulator, LytTR family D3H65_RS07500 ENOG4106YYS transcriptional regulatory protein D3H65_RS07510 ENOG4108UUM single-stranded DNA-binding protein D3H65_RS07520 ENOG4105CHU acetyl-coa acetyltransferase D3H65_RS07525 ENOG4105KY5 gCN5-related N-acetyltransferase D3H65_RS07545 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic D3H65_RS07570 ENOG4105C3G gtp-binding protein D3H65_RS07585 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS07605 ENOG4108IFH alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen D3H65_RS07620 ENOG4105VFU Rna-binding protein D3H65_RS07640 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) D3H65_RS07655 ENOG4107QWK SAICAR synthetase D3H65_RS07660 ENOG4105J1V Triacylglycerol lipase D3H65_RS07665 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) D3H65_RS07690 ENOG4105DS0 Transcriptional regulator, Crp Fnr family D3H65_RS07720 ENOG4105CHH sulfate transporter D3H65_RS07745 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) D3H65_RS07755 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) D3H65_RS07770 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component D3H65_RS07785 ENOG4108HRK Histidine kinase D3H65_RS07790 ENOG4108NEV two component transcriptional regulator, LytTR family D3H65_RS07795 ENOG4105EEI dihydropteroate synthase D3H65_RS07805 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) D3H65_RS07815 ENOG410804D Sensor Signal Transduction Histidine Kinase D3H65_RS07830 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS07870 ENOG4105NAE bifunctional deaminase-reductase domain protein D3H65_RS07900 ENOG4105DFY n-acylglucosamine 2-epimerase D3H65_RS07905 ENOG4105HY2 Glycosidase related protein D3H65_RS07915 ENOG4105D3P Mannan endo-1,4-beta-mannosidase D3H65_RS07930 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS08005 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) D3H65_RS08050 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS08060 ENOG4107Z3H Transcriptional regulator, TetR family D3H65_RS08065 ENOG4105C3M thioredoxin reductase D3H65_RS08070 ENOG4105EWI Short-chain dehydrogenase reductase Sdr D3H65_RS08075 ENOG4105BZS acriflavin resistance protein D3H65_RS08080 ENOG4105D0S secretion protein (HlyD D3H65_RS08115 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS08160 ENOG4105NAE bifunctional deaminase-reductase domain protein D3H65_RS08205 ENOG4108S01 response regulator D3H65_RS08215 ENOG4105CHR reductase D3H65_RS08225 ENOG4107V4F S-adenosyl-l-methionine hydroxide adenosyltransferase D3H65_RS08245 ENOG4105D4A Cell wall formation (By similarity) D3H65_RS08250 ENOG4105C25 Primosomal protein n' D3H65_RS08265 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) D3H65_RS08280 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) D3H65_RS08285 ENOG4105BZU Histidine kinase D3H65_RS08320 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) D3H65_RS08335 ENOG4105DVT helicase D3H65_RS08340 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) D3H65_RS08350 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) D3H65_RS08355 ENOG4105KEG ribosomal-protein-alanine acetyltransferase D3H65_RS08380 ENOG4108RJ9 Glycosyl transferase, family 2 D3H65_RS08390 ENOG4105C0K Gdp-mannose 4,6-dehydratase D3H65_RS08425 ENOG4108NEV two component transcriptional regulator, LytTR family D3H65_RS08435 ENOG4105EV6 Pfam:DUF178 D3H65_RS08440 ENOG4107QTF adenylosuccinate lyase D3H65_RS08450 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) D3H65_RS08465 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) D3H65_RS08470 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) D3H65_RS08475 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) D3H65_RS08510 ENOG4105D78 K07001 NTE family protein D3H65_RS08525 ENOG4105DIT ErfK YbiS YcfS YnhG family protein D3H65_RS08530 ENOG4105BZU Histidine kinase D3H65_RS08550 ENOG4105D6P C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity) D3H65_RS08560 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i D3H65_RS08575 ENOG4105CK6 Two component transcriptional regulator (Winged helix family D3H65_RS08585 ENOG4105CYC Transferase D3H65_RS08590 ENOG4105DE4 1-phosphofructokinase D3H65_RS08620 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic D3H65_RS08635 ENOG4105C5X domain protein D3H65_RS08675 ENOG4105C02 permease D3H65_RS08680 ENOG4107R76 Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) D3H65_RS08695 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic D3H65_RS08710 ENOG4105CY3 ABC transporter, permease D3H65_RS08735 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) D3H65_RS08740 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) D3H65_RS08765 ENOG4105DY9 regulatoR D3H65_RS08770 ENOG4108HRK Histidine kinase D3H65_RS08795 ENOG4108JUA Transcriptional regulator D3H65_RS08820 ENOG4108YIQ Alpha beta hydrolase D3H65_RS08845 ENOG4105F2F Xylan 1,4-beta-xylosidase (EC 3.2.1.37) D3H65_RS08850 ENOG4105CGS Alpha-glucosidase D3H65_RS08855 ENOG4107RF2 cellulose-binding family II protein D3H65_RS08860 ENOG4108K2F hydrolase Family 5 D3H65_RS08870 ENOG4105TT1 Ragb susd domain-containing protein D3H65_RS08875 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS08915 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS08925 ENOG4105CPQ Dehydrogenase D3H65_RS08935 ENOG4105QJH Domain of unknown function (DUF718) D3H65_RS08940 ENOG4105EDR glucose galactose transporter D3H65_RS08960 ENOG4105CGS Alpha-glucosidase D3H65_RS08980 ENOG4105W2Z cytochrome C, class I D3H65_RS09050 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS09075 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS09085 ENOG4105DYC esterase D3H65_RS09100 ENOG4105DYC esterase D3H65_RS09180 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS09205 ENOG4105CGS Alpha-glucosidase D3H65_RS09220 ENOG4105E4I Glycoside hydrolase family 28 D3H65_RS09225 ENOG4105EXC Acyl-transferase D3H65_RS09330 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS09350 ENOG4107RGD Major Facilitator superfamily D3H65_RS09395 ENOG4105BZU Histidine kinase D3H65_RS09400 ENOG4105XJC Two component transcriptional regulator (Winged helix family D3H65_RS09425 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) D3H65_RS09470 ENOG4105E1F short-chain dehydrogenase reductase D3H65_RS09490 ENOG4105VMP Transcriptional regulator D3H65_RS09535 ENOG4105CA0 peroxidase D3H65_RS09605 ENOG4106CKV Pap2 superfamily protein D3H65_RS09615 ENOG4105CIY formyltetrahydrofolate deformylase D3H65_RS09625 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) D3H65_RS09650 ENOG4108HRK Histidine kinase D3H65_RS09695 ENOG4105KVH Transcriptional regulator D3H65_RS09720 ENOG4105DDI hemolysin-type calcium-binding region D3H65_RS09760 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate D3H65_RS09770 ENOG4105DPW Major facilitator superfamily MFS_1 D3H65_RS09780 ENOG4105EV8 ectoine hydroxylase D3H65_RS09795 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) D3H65_RS09800 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) D3H65_RS09805 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) D3H65_RS09810 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) D3H65_RS09815 ENOG4105CK5 oxidoreductase D3H65_RS09835 ENOG4105CAK Cell division ATP-binding protein ftsE D3H65_RS09855 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase D3H65_RS09860 ENOG4105RHY Pfam:UPF0157 D3H65_RS09870 ENOG4108R6W Transcriptional regulator, ARAC family D3H65_RS09885 ENOG4108SMP Nad-dependent epimerase dehydratase D3H65_RS09895 ENOG4108ZAI phosphatidylglycerophosphatase a D3H65_RS09910 ENOG4108VTU Cdp-alcohol phosphatidyltransferase D3H65_RS09935 ENOG4105WH1 Two component transcriptional regulator luxr family D3H65_RS09940 ENOG4105BZU Histidine kinase D3H65_RS09950 ENOG4105C3M thioredoxin reductase D3H65_RS09990 ENOG4105CJ1 ABC, transporter D3H65_RS10025 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS10040 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) D3H65_RS10045 ENOG4108JUA Transcriptional regulator D3H65_RS10055 ENOG4105E0K tonB-dependent siderophore receptor D3H65_RS10060 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase D3H65_RS10070 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) D3H65_RS10075 ENOG4105EW9 transcriptional regulator AsnC family D3H65_RS10155 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS10180 ENOG4105CSH Transporter D3H65_RS10195 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS10215 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) D3H65_RS10220 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) D3H65_RS10225 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) D3H65_RS10230 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) D3H65_RS10280 ENOG4107S5I aldo keto reductase D3H65_RS10290 ENOG4105EEQ Na H antiporter D3H65_RS10295 ENOG41061MV Arylsulfatase D3H65_RS10305 ENOG4105DHU Bile acid D3H65_RS10375 ENOG4108EE5 Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) D3H65_RS10405 ENOG4105C72 UPF0176 protein D3H65_RS10490 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS10555 ENOG4105BZU Histidine kinase D3H65_RS10580 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) D3H65_RS10590 ENOG4107SUZ Sodium/hydrogen exchanger family D3H65_RS10605 ENOG4108HRK Histidine kinase D3H65_RS10610 ENOG4108NEV two component transcriptional regulator, LytTR family D3H65_RS10620 ENOG41082BM Transcriptional regulator, arsr family D3H65_RS10670 ENOG4105EKQ RNA-directed DNA polymerase D3H65_RS10680 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS10705 ENOG4107YJ4 chain length determinant protein D3H65_RS10720 ENOG4105CGN Glycosyl transferase (Group 1 D3H65_RS10730 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) D3H65_RS10740 ENOG4107T8Q Glycosyl transferase (Group 1 D3H65_RS10760 ENOG4105D3Q Sugar transferase D3H65_RS10765 ENOG4105CD3 dihydroorotase D3H65_RS10775 ENOG4105CKK Glycosyl transferase, family 2 D3H65_RS10800 ENOG41083DV d,d-heptose 1,7-bisphosphate phosphatase D3H65_RS10820 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) D3H65_RS10875 ENOG4108IPJ Membrane D3H65_RS10880 ENOG4105EJ9 Membrane D3H65_RS10890 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase D3H65_RS10895 ENOG4108YZ4 nudix hydrolase D3H65_RS10900 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) D3H65_RS10905 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) D3H65_RS10915 ENOG4108JYK Dehydrogenase D3H65_RS10925 ENOG4107R91 Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) D3H65_RS10945 ENOG4108IUK alpha amylase, catalytic D3H65_RS10950 ENOG4105CT4 transporter D3H65_RS10965 ENOG4107RRE RNA-directed DNA polymerase D3H65_RS10995 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) D3H65_RS11000 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) D3H65_RS11005 ENOG4105EDR glucose galactose transporter D3H65_RS11010 ENOG4105DKQ ROK family D3H65_RS11020 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) D3H65_RS11040 ENOG4108Z03 MAF-like protein D3H65_RS11050 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase D3H65_RS11055 ENOG4105CN1 protease D3H65_RS11080 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) D3H65_RS11115 ENOG4105C5A transporter D3H65_RS11120 ENOG4105E7W lamb ycsf family protein D3H65_RS11130 ENOG4105P4J Allophanate hydrolase, subunit 1 D3H65_RS11150 ENOG4108RMU ferritin dps family protein D3H65_RS11160 ENOG4108NEV two component transcriptional regulator, LytTR family D3H65_RS11165 ENOG4108HRK Histidine kinase D3H65_RS11185 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS11195 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) D3H65_RS11200 ENOG4105D9R oxidoreductase D3H65_RS11205 ENOG4108Z7R Chaperone CsaA D3H65_RS11210 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) D3H65_RS11215 ENOG4108UVJ appr-1-p processing domain protein D3H65_RS11225 ENOG410811Q Ferredoxin D3H65_RS11230 ENOG4105CEP NADH dehydrogenase D3H65_RS11235 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) D3H65_RS11295 ENOG4105C85 amino acid D3H65_RS11305 ENOG4105CPD ethanolamine ammonia-lyase D3H65_RS11310 ENOG4107FQ9 ethanolamine ammonia-lyase D3H65_RS11370 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 D3H65_RS11375 ENOG4105CFH Aspartokinase D3H65_RS11395 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) D3H65_RS11410 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase D3H65_RS11415 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase D3H65_RS11460 ENOG4105CUJ penicillin amidase D3H65_RS11480 ENOG4105IBP Cyclic peptide transporter D3H65_RS11510 ENOG41087PP glycosyltransferase MGT family D3H65_RS11515 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase D3H65_RS11520 ENOG4108EE5 Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) D3H65_RS11535 ENOG4105E98 transcriptional regulator DeoR family D3H65_RS11540 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS11555 ENOG4105E98 transcriptional regulator DeoR family D3H65_RS11560 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS11660 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS11710 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS11725 ENOG4105TT1 Ragb susd domain-containing protein D3H65_RS11740 ENOG4105C2C drug resistance transporter, Bcr CflA D3H65_RS11760 ENOG4105DSG hydrolase family 43 D3H65_RS11780 ENOG4105C0R drug resistance transporter emrb qaca subfamily D3H65_RS11795 ENOG4107Z3H Transcriptional regulator, TetR family D3H65_RS11820 ENOG4107SKW Inherit from COG: Alpha beta hydrolase D3H65_RS11835 ENOG4108K01 transcriptional regulator D3H65_RS11845 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) D3H65_RS11990 ENOG4108VAC response regulator D3H65_RS11995 ENOG4108HRK Histidine kinase D3H65_RS12010 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS12040 ENOG4105EFI regulatoR D3H65_RS12055 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS12085 ENOG4105DQ4 alcohol dehydrogenase D3H65_RS12115 ENOG4108Q9V regulatoR D3H65_RS12150 ENOG4105KVH Transcriptional regulator D3H65_RS12160 ENOG4107ZXU DSBA oxidoreductase D3H65_RS12240 ENOG4105C9K Endothelin-converting enzyme 1 D3H65_RS12275 ENOG4107XVH Transcriptional regulator D3H65_RS12285 ENOG4105DTQ mandelate racemase muconate lactonizing D3H65_RS12290 ENOG4107S1W 4-alpha-glucanotransferase D3H65_RS12300 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase D3H65_RS12305 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) D3H65_RS12310 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit D3H65_RS12315 ENOG4105C1P efflux transporter, rnd family, mfp subunit D3H65_RS12320 ENOG4105BZS acriflavin resistance protein D3H65_RS12330 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) D3H65_RS12340 ENOG41074B2 UPF0747 protein D3H65_RS12345 ENOG4107QMZ Dehydrogenase D3H65_RS12350 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) D3H65_RS12355 ENOG4105CTU Proline racemase D3H65_RS12365 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) D3H65_RS12370 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) D3H65_RS12380 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) D3H65_RS12390 ENOG41083ND 50S ribosomal protein L33 D3H65_RS12395 ENOG4105KDC 50s ribosomal protein l28 D3H65_RS12410 ENOG4107R33 ppx gppa phosphatase D3H65_RS12415 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) D3H65_RS12420 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) D3H65_RS12425 ENOG4105C26 Dehydrogenase D3H65_RS12430 ENOG4107QKZ Ompa motb domain protein D3H65_RS12435 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin D3H65_RS12460 ENOG4105CIH Imidazole acetol-phosphate transaminase D3H65_RS12520 ENOG4105CD3 dihydroorotase D3H65_RS12535 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS12560 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) D3H65_RS12585 ENOG4105TT1 Ragb susd domain-containing protein D3H65_RS12595 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) D3H65_RS12610 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) D3H65_RS12625 ENOG4105PFC Transcriptional regulator D3H65_RS12665 ENOG4105CTX dehydratase D3H65_RS12715 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS12735 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) D3H65_RS12755 ENOG4105KVH Transcriptional regulator D3H65_RS12770 ENOG4105CTM Glycoside hydrolase family 5 D3H65_RS12795 ENOG4108X7C Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) D3H65_RS12815 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS12830 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) D3H65_RS12835 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) D3H65_RS12840 ENOG4105VJV 50s ribosomal protein L35 D3H65_RS12860 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) D3H65_RS12865 ENOG4105C22 threonyL-tRNA synthetase D3H65_RS12910 ENOG4105C5H ABC transporter D3H65_RS12925 ENOG4105D78 K07001 NTE family protein D3H65_RS12950 ENOG4105CI2 imidazolone-5-propionate hydrolase D3H65_RS12965 ENOG4105BZP glycoside hydrolase 15-related D3H65_RS12975 ENOG4105CGP Urocanate hydratase D3H65_RS12980 ENOG4105C84 Histidine ammonia-lyase D3H65_RS12990 ENOG4105EAA nucleoside D3H65_RS13000 ENOG4105DZG Dehydrogenase D3H65_RS13025 ENOG4105DF6 Fe-S oxidoreductase D3H65_RS13030 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) D3H65_RS13080 ENOG4105DF6 Fe-S oxidoreductase D3H65_RS13125 ENOG4105BZU Histidine kinase D3H65_RS13130 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family D3H65_RS13145 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) D3H65_RS13150 ENOG4107RBB ABC transporter, permease D3H65_RS13165 ENOG4107RBB ABC transporter, permease D3H65_RS13170 ENOG4107R39 (ABC) transporter D3H65_RS13180 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) D3H65_RS13195 ENOG4107RBB ABC transporter, permease D3H65_RS13200 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) D3H65_RS13205 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) D3H65_RS13225 ENOG4108EE5 Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) D3H65_RS13230 ENOG4107RBB ABC transporter, permease D3H65_RS13235 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) D3H65_RS13240 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) D3H65_RS13275 ENOG4105C19 ABC transporter D3H65_RS13330 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) D3H65_RS13355 ENOG4105HHA aminodeoxychorismate lyase D3H65_RS13360 ENOG4107S2Z UPF0761 membrane protein D3H65_RS13395 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase D3H65_RS13420 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for D3H65_RS13440 ENOG4108V1T peptidylprolyl cis-trans isomerase D3H65_RS13480 ENOG4107RIV Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) D3H65_RS13485 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) D3H65_RS13495 ENOG4105KA0 thioesterase Superfamily protein D3H65_RS13500 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) D3H65_RS13505 ENOG4105CXT aspartate transcarbamylase D3H65_RS13510 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) D3H65_RS13535 ENOG4105C26 Dehydrogenase D3H65_RS13600 ENOG4108QXE glycerophosphoryl diester phosphodiesterase D3H65_RS13610 ENOG4107ZSV Receptor D3H65_RS13625 ENOG4105WXV 50S ribosomal protein L32 D3H65_RS13630 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) D3H65_RS13675 ENOG4105CUB amino acid D3H65_RS13700 ENOG4106YYS transcriptional regulatory protein D3H65_RS13720 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) D3H65_RS13725 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) D3H65_RS13730 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase D3H65_RS13735 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) D3H65_RS13750 ENOG4107QMU Mate efflux family protein D3H65_RS13755 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase D3H65_RS13760 ENOG4105C3M thioredoxin reductase D3H65_RS13770 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) D3H65_RS13795 ENOG4105CXB phosphoribosylaminoimidazole synthetase D3H65_RS13800 ENOG4105DTN riboflavin biosynthesis protein ribF D3H65_RS13805 ENOG4105TQK DNA polymerase iii, delta' subunit D3H65_RS13825 ENOG4105C5H ABC transporter D3H65_RS13840 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase D3H65_RS13845 ENOG4105E33 succinate dehydrogenase D3H65_RS13860 ENOG4108IDZ Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) D3H65_RS13865 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) D3H65_RS13880 ENOG4105DF5 DNA topoisomerase IV, subunit A D3H65_RS13885 ENOG4105FQP Beta-lactamase D3H65_RS13895 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase D3H65_RS13900 ENOG4105DNX Dna topoisomerase iv (Subunit b) D3H65_RS13925 ENOG4105DKW ABC transporter D3H65_RS13945 ENOG4108FN7 Aldo keto reductase D3H65_RS13960 ENOG4107RBB ABC transporter, permease D3H65_RS13995 ENOG4105WH1 Two component transcriptional regulator luxr family D3H65_RS14000 ENOG4108MR6 WD40-like Beta Propeller Repeat D3H65_RS14005 ENOG4105C0D helicase D3H65_RS14060 ENOG4105F1N DNA alkylation repair D3H65_RS14065 ENOG4105ETE Transcriptional regulator (LacI family D3H65_RS14080 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) D3H65_RS14105 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS14115 ENOG4105ETX regulatoR D3H65_RS14125 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) D3H65_RS14180 ENOG4107QX3 carboxylase D3H65_RS14200 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) D3H65_RS14210 ENOG4105EIP mannose-6-phosphate isomerase D3H65_RS14215 ENOG4105VFF UPF0102 protein D3H65_RS14225 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) D3H65_RS14260 ENOG4105DWY Agmatine deiminase D3H65_RS14275 ENOG4107W19 lmbE family D3H65_RS14285 ENOG4107QN2 dihydrolipoyl dehydrogenase D3H65_RS14295 ENOG4108HRK Histidine kinase D3H65_RS14300 ENOG4108NEV two component transcriptional regulator, LytTR family D3H65_RS14310 ENOG4105MWK D-amino acid dehydrogenase, small subunit D3H65_RS14370 ENOG41082BM Transcriptional regulator, arsr family D3H65_RS14385 ENOG4105CHP RNA polymerase D3H65_RS14390 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS14400 ENOG4107ZT5 Thiol disulfide interchange protein D3H65_RS14425 ENOG4105C7S Dehydrogenase D3H65_RS14450 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) D3H65_RS14455 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) D3H65_RS14460 ENOG4105DFU Cell wall formation (By similarity) D3H65_RS14480 ENOG4105C0H protease D3H65_RS14500 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) D3H65_RS14505 ENOG4105C34 Pseudouridine synthase D3H65_RS14515 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) D3H65_RS14520 ENOG4107ZNS Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) D3H65_RS14525 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) D3H65_RS14530 ENOG4105C2N RNA methyltransferase TrmH family group 3 D3H65_RS14535 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 D3H65_RS14540 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) D3H65_RS14550 ENOG4105CBX hi0933 family D3H65_RS14560 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) D3H65_RS14565 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) D3H65_RS14570 ENOG4105VPB 50S ribosomal protein L30 D3H65_RS14575 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) D3H65_RS14585 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) D3H65_RS14590 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) D3H65_RS14595 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) D3H65_RS14600 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits D3H65_RS14605 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) D3H65_RS14610 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) D3H65_RS14615 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal D3H65_RS14620 ENOG4108628 50s ribosomal protein l29 D3H65_RS14625 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) D3H65_RS14630 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) D3H65_RS14640 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) D3H65_RS14645 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity D3H65_RS14650 ENOG41082S5 One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) D3H65_RS14655 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) D3H65_RS14660 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) D3H65_RS14665 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) D3H65_RS14680 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) D3H65_RS14695 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) D3H65_RS14700 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) D3H65_RS14705 ENOG4105CM2 brancheD-chain amino acid aminotransferase D3H65_RS14720 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) D3H65_RS14740 ENOG4105E2X shikimate dehydrogenase D3H65_RS14765 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins D3H65_RS14770 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) D3H65_RS14785 ENOG4105II7 pyrroline-5-carboxylate reductase D3H65_RS14790 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) D3H65_RS14795 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii D3H65_RS14850 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein D3H65_RS14855 ENOG4105CAT Cytidine monophosphate kinase D3H65_RS14870 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) D3H65_RS14910 ENOG4105DY9 regulatoR D3H65_RS14955 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) D3H65_RS15015 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS15025 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) D3H65_RS15060 ENOG4108V1T peptidylprolyl cis-trans isomerase D3H65_RS15085 ENOG4107VAM peptidase, m28 D3H65_RS15090 ENOG4105C5H ABC transporter D3H65_RS15095 ENOG4105BZU Histidine kinase D3H65_RS15115 ENOG4105CPF Cell wall formation (By similarity) D3H65_RS15130 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding D3H65_RS15140 ENOG4105C0H protease D3H65_RS15145 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) D3H65_RS15150 ENOG4107RAJ Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) D3H65_RS15155 ENOG4105HCZ D3H65_RS15160 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) D3H65_RS15170 ENOG4105CJW magnesium transporter D3H65_RS15195 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) D3H65_RS15200 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit D3H65_RS15210 ENOG4105CMG Carbohydrate kinase D3H65_RS15220 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) D3H65_RS15250 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) D3H65_RS15280 ENOG4105ZMH deoxynucleoside kinase D3H65_RS15290 ENOG4105CKD glutathione-regulated potassium-efflux system protein D3H65_RS15310 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor D3H65_RS15365 ENOG4105C0R drug resistance transporter emrb qaca subfamily D3H65_RS15375 ENOG4108VAC response regulator D3H65_RS15400 ENOG4105CI2 imidazolone-5-propionate hydrolase D3H65_RS15405 ENOG4105CN1 protease D3H65_RS15420 ENOG4105CNM Receptor D3H65_RS15470 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) D3H65_RS15475 ENOG4105CY3 ABC transporter, permease D3H65_RS15490 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase D3H65_RS15515 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding D3H65_RS15520 ENOG4108XHQ (2Fe-2S)-binding domain protein D3H65_RS15605 ENOG4105K78 MarR family Transcriptional regulator D3H65_RS15650 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) D3H65_RS15660 ENOG4105F4R Transcriptional regulator mode D3H65_RS15675 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion D3H65_RS15680 ENOG4105CGK Exodeoxyribonuclease III D3H65_RS15690 ENOG4105KVH Transcriptional regulator D3H65_RS15695 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) D3H65_RS15700 ENOG4105E7U AraC family transcriptional regulator D3H65_RS15710 ENOG4105CPT Alpha beta hydrolase D3H65_RS15720 ENOG4105CHP RNA polymerase D3H65_RS15770 ENOG4105CK6 Two component transcriptional regulator (Winged helix family D3H65_RS15775 ENOG4105BZU Histidine kinase D3H65_RS15785 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) D3H65_RS15815 ENOG4105ID8 Transcriptional regulator, ARAC family D3H65_RS15830 ENOG4105F27 Major Facilitator D3H65_RS15880 ENOG4105CNT hydrolase family 2 D3H65_RS15895 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS15905 ENOG4105C6Z Gluconate D3H65_RS15915 ENOG4105C01 Dihydroxy-acid dehydratase D3H65_RS15925 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS15930 ENOG4105FTV AraC Family Transcriptional Regulator D3H65_RS15935 ENOG4105CMG Carbohydrate kinase D3H65_RS15940 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) D3H65_RS15945 ENOG4105CXK mandelate racemase muconate lactonizing D3H65_RS15950 ENOG4105C09 Bile acid D3H65_RS15960 ENOG4105CXK mandelate racemase muconate lactonizing D3H65_RS16040 ENOG4105Q2H domain protein D3H65_RS16065 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) D3H65_RS16070 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) D3H65_RS16075 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) D3H65_RS16080 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) D3H65_RS16085 ENOG4105D5Q Arginine ornithine antiporter D3H65_RS16095 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) D3H65_RS16100 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) D3H65_RS16105 ENOG4107B7Y DNA-binding transcriptional regulator FruR D3H65_RS16110 ENOG4105CWX Alpha-1,2-mannosidase D3H65_RS16120 ENOG4105CWX Alpha-1,2-mannosidase D3H65_RS16130 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS16135 ENOG4105ETE Transcriptional regulator (LacI family D3H65_RS16145 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS16150 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) D3H65_RS16155 ENOG4107VNI ribosomal protein l10 D3H65_RS16160 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) D3H65_RS16165 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) D3H65_RS16220 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) D3H65_RS16225 ENOG41083X6 30S ribosomal protein S21 D3H65_RS16230 ENOG4108R6K riboflavin synthase, subunit alpha D3H65_RS16270 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) D3H65_RS16300 ENOG4107S8C mandelate racemase muconate lactonizing D3H65_RS16325 ENOG4105CPQ Dehydrogenase D3H65_RS16345 ENOG4105DU6 RNA polymerase D3H65_RS16370 ENOG4107EF8 Glycosyl transferase (Group 1 D3H65_RS16380 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase D3H65_RS16385 ENOG4105C1B dTDP-glucose 4-6-dehydratase D3H65_RS16400 ENOG4105C6Y Udp-glucose 6-dehydrogenase D3H65_RS16405 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase D3H65_RS16410 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase D3H65_RS16420 ENOG4107T8J thymidine kinase D3H65_RS16495 ENOG4108JQ6 ABC transporter D3H65_RS16510 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) D3H65_RS16515 ENOG4107T8Q Glycosyl transferase (Group 1 D3H65_RS16535 ENOG4105CFH Aspartokinase D3H65_RS16550 ENOG4105XA0 heptosyltransferase ii D3H65_RS16555 ENOG4107RGD Major Facilitator superfamily D3H65_RS16560 ENOG4105DQR SNARE associated Golgi D3H65_RS16565 ENOG4107QJT sodium dicarboxylate symporter D3H65_RS16580 ENOG4108EE5 Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) D3H65_RS16590 ENOG4105JAB phenazine biosynthesis protein, phzf family D3H65_RS16595 ENOG4105EN6 Membrane D3H65_RS16600 ENOG4105CPP Dehydrogenase, E1 component D3H65_RS16620 ENOG4105CHM Aminotransferase D3H65_RS16695 ENOG4107WCI zn-dependent hydrolase of the beta-lactamase fold-like protein D3H65_RS16700 ENOG4105ENJ RND efflux system, outer membrane lipoprotein D3H65_RS16710 ENOG4105ENT Efflux transporter rnd family, mfp subunit D3H65_RS16725 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS16760 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS16795 ENOG4108PCN EamA-like transporter family D3H65_RS16805 ENOG4108HRK Histidine kinase D3H65_RS16810 ENOG4105DY9 regulatoR D3H65_RS16835 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase D3H65_RS16850 ENOG4105D3Q Sugar transferase D3H65_RS16875 ENOG4107TYR Glycosyl Transferase D3H65_RS16885 ENOG4105CPK Glycosyl transferase (Group 1 D3H65_RS16900 ENOG4105K64 Glycosyl transferase, family 2 D3H65_RS16930 ENOG4105BZ1 (ABC) transporter D3H65_RS16940 ENOG4105D75 Capsular exopolysaccharide family D3H65_RS16975 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) D3H65_RS17030 ENOG4105TT1 Ragb susd domain-containing protein D3H65_RS17065 ENOG4105KCK Peptidoglycan-associated lipoprotein D3H65_RS17080 ENOG4105CNT hydrolase family 2 D3H65_RS17125 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS17130 ENOG4105ETE Transcriptional regulator (LacI family D3H65_RS17140 ENOG4107BJW polysaccharide deacetylase D3H65_RS17180 ENOG4105C2F Histidine kinase D3H65_RS17185 ENOG4105DY9 regulatoR D3H65_RS17195 ENOG4105BZU Histidine kinase D3H65_RS17200 ENOG4105BZU Histidine kinase D3H65_RS17205 ENOG4105WH1 Two component transcriptional regulator luxr family D3H65_RS17215 ENOG4105BZU Histidine kinase D3H65_RS17220 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) D3H65_RS17225 ENOG4107RBB ABC transporter, permease D3H65_RS17290 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase D3H65_RS17330 ENOG4107WT5 transcriptional regulator (NifA D3H65_RS17380 ENOG4105EPC oxidoreductase D3H65_RS17390 ENOG41080TC multidrug resistance protein D3H65_RS17395 ENOG4105DJB Major Facilitator Superfamily D3H65_RS17400 ENOG4108UHU Aldolase D3H65_RS17410 ENOG4105D50 Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity) D3H65_RS17415 ENOG4105CHR reductase D3H65_RS17420 ENOG4105D2H Uronic isomerase D3H65_RS17425 ENOG4105CTX dehydratase D3H65_RS17430 ENOG4107QZW Altronate oxidoreductase D3H65_RS17440 ENOG4105F5H Glycosyl Hydrolase Family 88 D3H65_RS17475 ENOG4105E4I Glycoside hydrolase family 28 D3H65_RS17490 ENOG4107TDE lipolytic protein G-D-S-L family D3H65_RS17510 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS17515 ENOG4105ETE Transcriptional regulator (LacI family D3H65_RS17540 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) D3H65_RS17550 ENOG4105TT1 Ragb susd domain-containing protein D3H65_RS17555 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS17575 ENOG4105BZ1 (ABC) transporter D3H65_RS17615 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) D3H65_RS17625 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) D3H65_RS17650 ENOG4105ECQ AraC Family Transcriptional Regulator D3H65_RS17655 ENOG4105DZQ phospholipase D Transphosphatidylase D3H65_RS17670 ENOG4105D9R oxidoreductase D3H65_RS17690 ENOG4105CN9 Peptidase m42 family protein D3H65_RS17715 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) D3H65_RS17720 ENOG4105WH1 Two component transcriptional regulator luxr family D3H65_RS17730 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) D3H65_RS17755 ENOG4108NEV two component transcriptional regulator, LytTR family D3H65_RS17760 ENOG4105BZU Histidine kinase D3H65_RS17775 ENOG4107W2A UPF0173 metal-dependent hydrolase D3H65_RS17780 ENOG4107QJE Chromosome Partitioning Protein D3H65_RS17785 ENOG4105FA0 parb-like partition protein D3H65_RS17795 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) D3H65_RS17800 ENOG4108Q9V regulatoR D3H65_RS17805 ENOG4107YXA Transcriptional regulator, BadM Rrf2 family D3H65_RS17815 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) D3H65_RS17845 ENOG4105F0N pyrophosphate phospho-hydrolase D3H65_RS17850 ENOG4107SN7 NLP P60 protein D3H65_RS17865 ENOG4107Y2X deaminase D3H65_RS17885 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase D3H65_RS17920 ENOG4105FFC UPF0187 protein D3H65_RS17930 ENOG4105GRZ Ycii-related protein D3H65_RS17955 ENOG4107XMK single-stranded DNA-binding protein D3H65_RS17960 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) D3H65_RS17980 ENOG4105ENE Histidine kinase D3H65_RS17985 ENOG4105WH1 Two component transcriptional regulator luxr family D3H65_RS17995 ENOG4105C7S Dehydrogenase D3H65_RS18005 ENOG4105RA3 Binds directly to 16S ribosomal RNA (By similarity) D3H65_RS18025 ENOG4105EY8 ABC transporter D3H65_RS18040 ENOG410822N TonB family D3H65_RS18050 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) D3H65_RS18055 ENOG4108KPJ rna polymerase sigma factor D3H65_RS18060 ENOG4105DN3 alpha-2-macroglobulin domain protein D3H65_RS18065 ENOG4105DFS Conserved Protein D3H65_RS18070 ENOG4108JQB penicillin-binding protein 1C D3H65_RS18080 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) D3H65_RS18095 ENOG4107T0X DNA ligase D3H65_RS18120 ENOG4105CA0 peroxidase D3H65_RS18130 ENOG4105DGU Histone deacetylase D3H65_RS18145 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving D3H65_RS18155 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase D3H65_RS18200 ENOG4105CI2 imidazolone-5-propionate hydrolase D3H65_RS18205 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) D3H65_RS18210 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) D3H65_RS18260 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family D3H65_RS18270 ENOG4105CZV ABC transporter D3H65_RS18275 ENOG4105C6K Malic enzyme D3H65_RS18285 ENOG4105DHJ ABC, transporter D3H65_RS18290 ENOG4105CH7 arginosuccinase D3H65_RS18295 ENOG4105KVH Transcriptional regulator D3H65_RS18335 ENOG4105C9M aspartyl-trna synthetase D3H65_RS18340 ENOG4105WH1 Two component transcriptional regulator luxr family D3H65_RS18355 ENOG4105ENE Histidine kinase D3H65_RS18360 ENOG4105WH1 Two component transcriptional regulator luxr family D3H65_RS18375 ENOG4105D6N CoA-transferase, subunit a D3H65_RS18415 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) D3H65_RS18420 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) D3H65_RS18435 ENOG41080B9 Binds together with S18 to 16S ribosomal RNA (By similarity) D3H65_RS18440 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) D3H65_RS18445 ENOG4105K9Q Binds to the 23S rRNA (By similarity) D3H65_RS18450 ENOG4105DIT ErfK YbiS YcfS YnhG family protein D3H65_RS18455 ENOG4105VFU Rna-binding protein D3H65_RS18460 ENOG4105C3Q Glycosyl transferase, family 2 D3H65_RS18470 ENOG4107TE5 Lipid kinase D3H65_RS18490 ENOG4105C1J atp-dependent rna helicase D3H65_RS18495 ENOG4108XB2 Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) D3H65_RS18510 ENOG4105D9R oxidoreductase D3H65_RS18515 ENOG4105CJ2 (LipO)protein D3H65_RS18525 ENOG4108VAC response regulator D3H65_RS18530 ENOG4108HRK Histidine kinase D3H65_RS18585 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) D3H65_RS18615 ENOG4108V0P LemA family D3H65_RS18625 ENOG4105BZU Histidine kinase D3H65_RS18630 ENOG4105BZA Phosphoglycerate kinase D3H65_RS18685 ENOG4105BZ1 (ABC) transporter D3H65_RS18730 ENOG4108NKV transcriptional regulator D3H65_RS18775 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS18780 ENOG4105BZU Histidine kinase D3H65_RS18790 ENOG4105DY9 regulatoR D3H65_RS18800 ENOG4105CY0 Metallo-Beta-Lactamase D3H65_RS18825 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) D3H65_RS18830 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) D3H65_RS18840 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) D3H65_RS18855 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) D3H65_RS18860 ENOG4105D8V Glucose sorbosone dehydrogenase D3H65_RS18875 ENOG4105E66 phosphoriboisomerase A D3H65_RS18880 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family D3H65_RS18910 ENOG41061MV Arylsulfatase D3H65_RS18920 ENOG4105CNT hydrolase family 2 D3H65_RS18925 ENOG4105F5H Glycosyl Hydrolase Family 88 D3H65_RS18930 ENOG4107TDE lipolytic protein G-D-S-L family D3H65_RS18935 ENOG4105CX8 fg-gap repeat protein D3H65_RS18940 ENOG4105CX8 fg-gap repeat protein D3H65_RS19000 ENOG4107TDE lipolytic protein G-D-S-L family D3H65_RS19005 ENOG4105TT1 Ragb susd domain-containing protein D3H65_RS19025 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS19035 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS19065 ENOG4108SVW integral membrane protein D3H65_RS19070 ENOG4108HRK Histidine kinase D3H65_RS19075 ENOG4105DY9 regulatoR D3H65_RS19090 ENOG4105C9F isomerase D3H65_RS19095 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) D3H65_RS19105 ENOG4107YRA Uptake of L-rhamnose across the boundary membrane with the concomitant transport of protons into the cell (symport system) (By similarity) D3H65_RS19120 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS19125 ENOG4105E2R ROK family D3H65_RS19200 ENOG4107EXU Short-chain dehydrogenase reductase Sdr D3H65_RS19205 ENOG4105DJB Major Facilitator Superfamily D3H65_RS19220 ENOG4105EY3 heparinase II III family protein D3H65_RS19230 ENOG4107YCY Transcriptional regulator D3H65_RS19270 ENOG4105TT1 Ragb susd domain-containing protein D3H65_RS19270 ENOG4105TT1 Ragb susd domain-containing protein D3H65_RS19275 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS19310 ENOG4107TE5 Lipid kinase D3H65_RS19340 ENOG4105F0I Aminotransferase D3H65_RS19350 ENOG4108VHC Short-chain dehydrogenase reductase Sdr D3H65_RS19375 ENOG4105C6T cysteine synthase D3H65_RS19380 ENOG4108KPZ tonB-dependent Receptor D3H65_RS19390 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) D3H65_RS19430 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) D3H65_RS19435 ENOG4105C8S subunit m D3H65_RS19440 ENOG4105D65 subunit l D3H65_RS19445 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) D3H65_RS19450 ENOG4107UFS subunit j D3H65_RS19455 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) D3H65_RS19460 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) D3H65_RS19475 ENOG4105GKE subunit e D3H65_RS19480 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) D3H65_RS19485 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain D3H65_RS19490 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) D3H65_RS19495 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain D3H65_RS19535 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) D3H65_RS19550 ENOG4105CHU acetyl-coa acetyltransferase D3H65_RS19560 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs D3H65_RS19565 ENOG4105FE9 pseudouridine synthase D3H65_RS19570 ENOG4105C34 Pseudouridine synthase D3H65_RS19575 ENOG4105CI2 imidazolone-5-propionate hydrolase D3H65_RS19580 ENOG4105D3R alkyl hydroperoxide reductase D3H65_RS19585 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) D3H65_RS19615 ENOG4108NEV two component transcriptional regulator, LytTR family D3H65_RS19620 ENOG4107YAY An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) D3H65_RS19625 ENOG4105K5M 30s ribosomal protein S16 D3H65_RS19635 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) D3H65_RS19695 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) D3H65_RS19700 ENOG4105VEJ Heat shock protein D3H65_RS19710 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) D3H65_RS19715 ENOG4105CJQ hydrolase, family 31 D3H65_RS19725 ENOG4105CPN adenine deaminase D3H65_RS19745 ENOG4108HRK Histidine kinase D3H65_RS19750 ENOG4108NEV two component transcriptional regulator, LytTR family D3H65_RS19825 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) D3H65_RS19835 ENOG4108VX5 3-methyladenine DNA glycosylase D3H65_RS19845 ENOG4105QD8 tetrapyrrole corrin porphyrin D3H65_RS19860 ENOG4105CPK Glycosyl transferase (Group 1 D3H65_RS19875 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) D3H65_RS19880 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) D3H65_RS19895 ENOG4105E6M Sulphatase-modifying factor protein D3H65_RS19900 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) D3H65_RS19910 ENOG4105C28 cystathionine D3H65_RS19920 ENOG4105DWV Homoserine O-trans-acetylase D3H65_RS19930 ENOG410635A Membrane D3H65_RS19940 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) D3H65_RS19945 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) D3H65_RS19955 ENOG4105C11 sulfate adenylyltransferase), subunit 2 D3H65_RS19965 ENOG4105E6M Sulphatase-modifying factor protein D3H65_RS19985 ENOG4108I0Z Aconitate hydratase D3H65_RS20000 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase D3H65_RS20015 ENOG4105EXW epimerase dehydratase D3H65_RS20025 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 D3H65_RS20090 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) D3H65_RS20095 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) D3H65_RS20115 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase D3H65_RS20120 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein D3H65_RS20125 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) D3H65_RS20160 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) D3H65_RS20195 ENOG4105D3G Pseudouridine synthase D3H65_RS20205 ENOG4108EE5 Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) D3H65_RS20210 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) D3H65_RS20215 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) D3H65_RS20255 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) D3H65_RS20260 ENOG4105KAV tspo and mbr like protein D3H65_RS20270 ENOG4105EWK phytoene D3H65_RS20275 ENOG4105DY9 regulatoR D3H65_RS20280 ENOG4108HRK Histidine kinase D3H65_RS20290 ENOG4105EUJ GTP cyclohydrolase i D3H65_RS20340 ENOG4105CHR reductase D3H65_RS20420 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) D3H65_RS20430 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) D3H65_RS20440 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) D3H65_RS20445 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) D3H65_RS20450 ENOG41082BV acetyltransferase D3H65_RS20455 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) D3H65_RS20465 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) D3H65_RS20470 ENOG4105DKB L-sorbosone dehydrogenase D3H65_RS20495 ENOG4105C5X domain protein D3H65_RS20560 ENOG4107RE3 peptidase, S41 D3H65_RS20565 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) D3H65_RS20570 ENOG4105C6V Glycerol-3-phosphate dehydrogenase D3H65_RS20575 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) D3H65_RS20585 ENOG4105C8Y Acetylornithine aminotransferase D3H65_RS20600 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) D3H65_RS20605 ENOG4107QVM von Willebrand factor, type A D3H65_RS20620 ENOG4105C7R Atpase associated with various cellular activities aaa_3 D3H65_RS20655 ENOG4107QYD Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) D3H65_RS20665 ENOG4108RCS geranylgeranylglyceryl phosphate synthase D3H65_RS20675 ENOG4108ETT Dehydrogenase D3H65_RS20705 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase D3H65_RS20710 ENOG4105C8Y Acetylornithine aminotransferase D3H65_RS20715 ENOG4107REN Carbamoyltransferase D3H65_RS20720 ENOG4107T6X nag kinase D3H65_RS20725 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) D3H65_RS20730 ENOG4105CH7 arginosuccinase D3H65_RS20745 ENOG4105D64 Mechanosensitive ion channel D3H65_RS20765 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) D3H65_RS20770 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) D3H65_RS20780 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase D3H65_RS20820 ENOG4105WH1 Two component transcriptional regulator luxr family D3H65_RS20825 ENOG4105BZU Histidine kinase D3H65_RS20830 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen D3H65_RS20840 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain D3H65_RS20850 ENOG4105WH1 Two component transcriptional regulator luxr family D3H65_RS20855 ENOG4105BZU Histidine kinase D3H65_RS20870 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 D3H65_RS20875 ENOG4105DC1 bifunctional purine biosynthesis protein purh D3H65_RS20880 ENOG4105FDR Membrane D3H65_RS20890 ENOG4107QR9 Iron-sulfur cluster binding protein D3H65_RS20910 ENOG4105C37 (CBS) domain D3H65_RS20915 ENOG4108UUM single-stranded DNA-binding protein D3H65_RS20920 ENOG4105CEN a g-specific adenine glycosylase D3H65_RS20925 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) D3H65_RS20935 ENOG4105C03 ribonuclease D3H65_RS20950 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) D3H65_RS20955 ENOG4105MJ2 Competence protein D3H65_RS20965 ENOG4108V06 Glutathione peroxidase D3H65_RS20975 ENOG4105MA4 psp1 domain protein D3H65_RS20985 ENOG4107MM9 BNR Asp-box repeat-containing protein D3H65_RS20995 ENOG4105C3M thioredoxin reductase D3H65_RS21000 ENOG4105C2F Histidine kinase D3H65_RS21005 ENOG4105DY9 regulatoR D3H65_RS21010 ENOG4105E98 transcriptional regulator DeoR family D3H65_RS21035 ENOG4105UYK outer membrane protein a D3H65_RS21060 ENOG4107TPS domain protein D3H65_RS21065 ENOG4108VCT Sulfite exporter TauE/SafE D3H65_RS21075 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) D3H65_RS21080 ENOG4105DS0 Transcriptional regulator, Crp Fnr family D3H65_RS21105 ENOG4108KDQ Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons (By similarity) D3H65_RS21140 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS21150 ENOG4105CHR reductase D3H65_RS21165 ENOG4105C3J Cysteine desulfurase D3H65_RS21175 ENOG4105KT7 mgtC SapB transporter D3H65_RS21185 ENOG4108ZJ4 polysaccharide deacetylase D3H65_RS21205 ENOG4108AHD Transcriptional regulator D3H65_RS21265 ENOG4108HRK Histidine kinase D3H65_RS21270 ENOG4108HRK Histidine kinase D3H65_RS21275 ENOG4108VAC response regulator D3H65_RS21305 ENOG4107YH7 Beta-lactamase (EC 3.5.2.6) D3H65_RS21325 ENOG4105BZU Histidine kinase D3H65_RS21330 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family D3H65_RS21345 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) D3H65_RS21350 ENOG4105C3R Methionine synthase D3H65_RS21355 ENOG4105C3R Methionine synthase D3H65_RS21375 ENOG4108NEV two component transcriptional regulator, LytTR family D3H65_RS21385 ENOG4105CGK Exodeoxyribonuclease III D3H65_RS21395 ENOG4105K70 DNA-binding protein D3H65_RS21405 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) D3H65_RS21415 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) D3H65_RS21420 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) D3H65_RS21425 ENOG4105CE9 30S ribosomal protein S2 D3H65_RS21430 ENOG4108UJD 30S ribosomal protein S9 D3H65_RS21435 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) D3H65_RS21475 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) D3H65_RS21490 ENOG4105KBX Transcriptional regulator, TetR family D3H65_RS21500 ENOG410624X efflux transporter, rnd family, mfp subunit D3H65_RS21505 ENOG4105BZS acriflavin resistance protein D3H65_RS21525 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) D3H65_RS21530 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase D3H65_RS21535 ENOG4105DMT epimerase dehydratase D3H65_RS21545 ENOG4108HRK Histidine kinase D3H65_RS21550 ENOG4108VAC response regulator D3H65_RS21555 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) D3H65_RS21560 ENOG4108R99 pseudouridine synthase D3H65_RS21580 ENOG4105CK6 Two component transcriptional regulator (Winged helix family D3H65_RS21590 ENOG4107ZQV short-chain dehydrogenase reductase D3H65_RS21600 ENOG41071I4 Phosphatidylserine decarboxylase proenzyme D3H65_RS21605 ENOG4105KNE Phosphatidate cytidylyltransferase D3H65_RS21615 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) D3H65_RS21620 ENOG4107VAM peptidase, m28 D3H65_RS21630 ENOG4108V06 Glutathione peroxidase D3H65_RS21635 ENOG4105C26 Dehydrogenase D3H65_RS21640 ENOG4107R6D beta-lactam binding protein AmpH D3H65_RS21660 ENOG4105NXH GreA GreB family elongation factor D3H65_RS21680 ENOG4105E08 Glycoside hydrolase, family 9 D3H65_RS21715 ENOG4105KME endoribonuclease L-psp D3H65_RS21725 ENOG4105N14 lysine exporter protein LysE YggA D3H65_RS21730 ENOG4105C28 cystathionine D3H65_RS21740 ENOG4105CAQ asparagine synthetase D3H65_RS21775 ENOG4108YZG isomerase D3H65_RS21780 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) D3H65_RS21785 ENOG4108JU5 Magnesium and cobalt efflux protein D3H65_RS21790 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) D3H65_RS21795 ENOG4108VAC response regulator D3H65_RS21800 ENOG4108HRK Histidine kinase D3H65_RS21835 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) D3H65_RS21890 ENOG4105U5Y Transcriptional regulator D3H65_RS21900 ENOG4105C0R drug resistance transporter emrb qaca subfamily D3H65_RS21915 ENOG4105CRK lysyL-tRNA synthetase D3H65_RS21925 ENOG4105CKV Membrane D3H65_RS21930 ENOG4107XC4 flavin reductase domain protein, FMN-binding D3H65_RS21950 ENOG4108Z6B deaminase D3H65_RS21960 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) D3H65_RS21970 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) D3H65_RS21975 ENOG4105WG6 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) D3H65_RS21980 ENOG4105VG0 50S ribosomal protein l34 D3H65_RS21990 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) D3H65_RS22005 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane D3H65_RS22010 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) D3H65_RS22020 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) D3H65_RS22045 ENOG4105KTH gatB Yqey D3H65_RS22060 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) D3H65_RS22085 ENOG4108VAC response regulator D3H65_RS22095 ENOG4108HRK Histidine kinase D3H65_RS22105 ENOG4105CI3 gtp-binding protein typa D3H65_RS22115 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) D3H65_RS22135 ENOG4107TE5 Lipid kinase D3H65_RS22145 ENOG4107TQK Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) D3H65_RS22170 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) D3H65_RS22185 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) D3H65_RS22195 ENOG4105DQU oxidoreductase, subunit beta D3H65_RS22205 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein D3H65_RS22220 ENOG4105VFU Rna-binding protein D3H65_RS22230 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) D3H65_RS22245 ENOG4108VBH Uncharacterized protein conserved in bacteria (DUF2251) D3H65_RS22255 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase D3H65_RS22260 ENOG4105C1G acyl-Coa dehydrogenase D3H65_RS22275 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 D3H65_RS22280 ENOG4105CND Glycosyl transferase, family 2 D3H65_RS22285 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component D3H65_RS22295 ENOG4108VVK transcriptional Regulator, AsnC D3H65_RS22305 ENOG4107UGT Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) D3H65_RS22315 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) D3H65_RS22325 ENOG4108SJC Membrane D3H65_RS22340 ENOG4107QS1 Cytochrome C Oxidase, Subunit III D3H65_RS22350 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) D3H65_RS22355 ENOG4105BZ9 Cytochrome C oxidase, subunit I D3H65_RS22385 ENOG4107SFQ iron-sulfur binding D3H65_RS22395 ENOG4108V3E phosphoribosylglycinamide formyltransferase D3H65_RS22415 ENOG4105FQP Beta-lactamase D3H65_RS22430 ENOG4105VDW Csbd family D3H65_RS22445 ENOG4107SQI penicillin amidase D3H65_RS22460 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS22495 ENOG4105CPP Dehydrogenase, E1 component D3H65_RS22515 ENOG41086DT Membrane protein of unknown function D3H65_RS22530 ENOG4105C0H protease D3H65_RS22535 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) D3H65_RS22540 ENOG4105BZU Histidine kinase D3H65_RS22595 ENOG4105KZX Pterin carbinolamine dehydratase D3H65_RS22615 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) D3H65_RS22620 ENOG4108N5B 2-phosphosulfolactate phosphatase D3H65_RS22630 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) D3H65_RS22675 ENOG4105C5S asparaginyl-tRNA synthetase D3H65_RS22680 ENOG4105C5I Dehydrogenase D3H65_RS22685 ENOG4105CE1 Ferrous iron transport protein b D3H65_RS22720 ENOG4105CHM Aminotransferase D3H65_RS22725 ENOG4105KME endoribonuclease L-psp D3H65_RS22735 ENOG4105CJT Mannose-1-phosphate guanylyltransferase D3H65_RS22740 ENOG4105C2X Arabinose 5-phosphate isomerase D3H65_RS22745 ENOG4105C9U ATP-dependent DNA helicase RecQ D3H65_RS22760 ENOG4105EHZ conserved protein UCP016719 D3H65_RS22765 ENOG4105VFU Rna-binding protein D3H65_RS22775 ENOG4107RAQ aminopeptidase D3H65_RS22790 ENOG4107RBB ABC transporter, permease D3H65_RS22825 ENOG4108HRK Histidine kinase D3H65_RS22855 ENOG4108KF3 Electron transport protein SCO1 SenC D3H65_RS22865 ENOG41083MR nifu domain-containing protein D3H65_RS22920 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) D3H65_RS22950 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) D3H65_RS22955 ENOG4105DKQ ROK family D3H65_RS22960 ENOG4107RJC Iron-containing alcohol dehydrogenase D3H65_RS22970 ENOG4105D7N magnesium and cobalt transport protein CorA D3H65_RS22980 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii D3H65_RS22985 ENOG4105C4M (Ubiquinol oxidase) subunit I D3H65_RS23000 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) D3H65_RS23005 ENOG4108ZGC gaf domain protein D3H65_RS23010 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) D3H65_RS23015 ENOG41080AX Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) D3H65_RS23025 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) D3H65_RS23050 ENOG4105BZU Histidine kinase D3H65_RS23060 ENOG4105CZ7 nitrilase cyanide hydratase and apolipoprotein n-acyltransferase D3H65_RS23065 ENOG4105CE4 GlcNAc 6-P deacetylase D3H65_RS23080 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) D3H65_RS23085 ENOG4105ECY inositol monophosphatase D3H65_RS23125 ENOG4108UMS Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase (By similarity) D3H65_RS23130 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase D3H65_RS23175 ENOG4108HRK Histidine kinase D3H65_RS23200 ENOG4105FQP Beta-lactamase D3H65_RS23210 ENOG4105BZ1 (ABC) transporter D3H65_RS23215 ENOG4105C1J atp-dependent rna helicase D3H65_RS23245 ENOG4105EGS Mechanosensitive ion channel D3H65_RS23255 ENOG4105C2M dna polymerase I D3H65_RS23260 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) D3H65_RS23265 ENOG4108Z5K methylglyoxal synthase D3H65_RS23275 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) D3H65_RS23315 ENOG4105EEQ Na H antiporter D3H65_RS23330 ENOG4107QUV Domain protein D3H65_RS23335 ENOG4105C4R Atp-dependent dna helicase D3H65_RS23340 ENOG4108NEV two component transcriptional regulator, LytTR family D3H65_RS23350 ENOG4105DEN Luciferase family D3H65_RS23370 ENOG4105C0D helicase D3H65_RS23405 ENOG4108TGP Thioesterase superfamily protein D3H65_RS23410 ENOG4105BZU Histidine kinase D3H65_RS23415 ENOG4107RT3 EamA-like transporter family D3H65_RS23440 ENOG4105BZU Histidine kinase D3H65_RS23445 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family D3H65_RS23450 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) D3H65_RS23455 ENOG4107RBB ABC transporter, permease D3H65_RS23460 ENOG4105C19 ABC transporter D3H65_RS23495 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) D3H65_RS23505 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase D3H65_RS23510 ENOG4105F32 YngK protein D3H65_RS23525 ENOG4108BB0 Elp3 D3H65_RS23535 ENOG4108UQ1 hydrolase, family 25 D3H65_RS23595 ENOG4105W2Z cytochrome C, class I D3H65_RS23615 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) D3H65_RS23625 ENOG4105QIV RNA polymerase D3H65_RS23680 ENOG4105DIT ErfK YbiS YcfS YnhG family protein D3H65_RS23685 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) D3H65_RS23710 ENOG410756H nucleotidyltransferase D3H65_RS23770 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) D3H65_RS23805 ENOG4105E7D Protein of unknown function (DUF3375) D3H65_RS23815 ENOG4108UJV acyl-CoA thioesterase i D3H65_RS23820 ENOG4108I0Y (ABC) transporter D3H65_RS23855 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS23880 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein D3H65_RS23890 ENOG4105DU6 RNA polymerase D3H65_RS23900 ENOG4105F0F Oxalate decarboxylase D3H65_RS23910 ENOG4108YIQ Alpha beta hydrolase D3H65_RS23915 ENOG4108RMU ferritin dps family protein D3H65_RS23920 ENOG4108NEV two component transcriptional regulator, LytTR family D3H65_RS23925 ENOG4105BZU Histidine kinase D3H65_RS23950 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) D3H65_RS23960 ENOG4105E98 transcriptional regulator DeoR family D3H65_RS23965 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS23975 ENOG4108I5G Major Facilitator superfamily D3H65_RS23980 ENOG4105CBX hi0933 family D3H65_RS23990 ENOG41088CQ domain protein D3H65_RS23995 ENOG4105IE8 Alpha-ketoglutarate permease D3H65_RS24000 ENOG4108M3J Dehydrogenase D3H65_RS24005 ENOG4107U6E carbohydrate kinase FGGY D3H65_RS24010 ENOG4105CMG Carbohydrate kinase D3H65_RS24015 ENOG4105CVJ phosphoglycerate mutase D3H65_RS24065 ENOG4105BZU Histidine kinase D3H65_RS24075 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) D3H65_RS24105 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS24140 ENOG4107QK4 glycoside hydrolase, family 3 domain protein D3H65_RS24145 ENOG4105CBG Sulfatase D3H65_RS24165 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS24180 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit D3H65_RS24185 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit D3H65_RS24190 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit D3H65_RS24195 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit D3H65_RS24200 ENOG4108UKI Enoyl-CoA hydratase D3H65_RS24205 ENOG4108ZJI phenylacetic acid degradation protein D3H65_RS24215 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control D3H65_RS24235 ENOG4105CZH peptidase D3H65_RS24250 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) D3H65_RS24255 ENOG4105C8N cysteinyl-tRNA synthetase D3H65_RS24275 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) D3H65_RS24280 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) D3H65_RS24295 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) D3H65_RS24315 ENOG4105U5Y Transcriptional regulator D3H65_RS24320 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) D3H65_RS24335 ENOG41090IP Required for maturation of 30S ribosomal subunits (By similarity) D3H65_RS24340 ENOG4105CHV Transcription elongation factor NusA D3H65_RS24345 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) D3H65_RS24350 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) D3H65_RS24355 ENOG4105BZU Histidine kinase D3H65_RS24360 ENOG4105WH1 Two component transcriptional regulator luxr family D3H65_RS24365 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase D3H65_RS24370 ENOG4105WH1 Two component transcriptional regulator luxr family D3H65_RS24475 ENOG4105CHM Aminotransferase D3H65_RS24490 ENOG4105CKK Glycosyl transferase, family 2 D3H65_RS24495 ENOG4108YYC ycei family D3H65_RS24505 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) D3H65_RS24510 ENOG4105SYT Methylenetetrahydrofolate reductase D3H65_RS24515 ENOG4108IUZ ABC transporter D3H65_RS24525 ENOG4105CHR reductase D3H65_RS24535 ENOG4105DXM phenylacetic acid degradation protein D3H65_RS24550 ENOG4105C0H protease D3H65_RS24575 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) D3H65_RS24580 ENOG4105E0X reductase D3H65_RS24585 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS24625 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS24645 ENOG4108IQE Amp-dependent synthetase and ligase D3H65_RS24650 ENOG4105DY8 decarboxylase D3H65_RS24655 ENOG4105CM2 brancheD-chain amino acid aminotransferase D3H65_RS24670 ENOG4106F60 Histidine kinase D3H65_RS24675 ENOG4105CK6 Two component transcriptional regulator (Winged helix family D3H65_RS24685 ENOG41082BM Transcriptional regulator, arsr family D3H65_RS24695 ENOG4105BZS acriflavin resistance protein D3H65_RS24705 ENOG4105VG1 fes assembly suf system protein D3H65_RS24710 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) D3H65_RS24715 ENOG4105C9B Cysteine desulfurase D3H65_RS24725 ENOG4105C3K feS assembly ATPase SufC D3H65_RS24735 ENOG4108YX9 iron--sulfur cluster insertion protein erpA D3H65_RS24745 ENOG4107T1U Catalyzes the synthesis of activated sulfate (By similarity) D3H65_RS24755 ENOG4105C2C drug resistance transporter, Bcr CflA D3H65_RS24760 ENOG4107TE5 Lipid kinase D3H65_RS24770 ENOG4105JVQ RNA Polymerase D3H65_RS24780 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) D3H65_RS24790 ENOG4105D17 glycoside hydrolase, family 3 domain protein D3H65_RS24795 ENOG41077A9 carbonic anhydrase D3H65_RS24800 ENOG4105CJ1 ABC, transporter D3H65_RS24810 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) D3H65_RS24825 ENOG4105CSM endonuclease III D3H65_RS24850 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein D3H65_RS24860 ENOG41077A9 carbonic anhydrase D3H65_RS24880 ENOG4105CSH Transporter D3H65_RS24885 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) D3H65_RS24925 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) D3H65_RS24930 ENOG4105KME endoribonuclease L-psp D3H65_RS24935 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase D3H65_RS24940 ENOG41072GX Peptidase M22 Glycoprotease D3H65_RS24945 ENOG41080HT Transcriptional regulator, arsr family D3H65_RS24950 ENOG4107TPS domain protein D3H65_RS24965 ENOG4105BZU Histidine kinase D3H65_RS24985 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) D3H65_RS24995 ENOG4108IYU L-aspartate oxidase D3H65_RS25010 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) D3H65_RS25025 ENOG4105D29 Helix-turn-helix type 11 domain protein D3H65_RS25030 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) D3H65_RS25055 ENOG4105E53 ec 3.2.1.28 D3H65_RS25090 ENOG4105D5P Methylmalonyl-coA mutase D3H65_RS25095 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) D3H65_RS25105 ENOG4108Z0Z intracellular protease Pfpi family D3H65_RS25115 ENOG4105C1J atp-dependent rna helicase D3H65_RS25150 ENOG4105CBG Sulfatase D3H65_RS25155 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) D3H65_RS25160 ENOG4105KT5 UmuD protein D3H65_RS25200 ENOG4105WH1 Two component transcriptional regulator luxr family D3H65_RS25260 ENOG4105E0Y RtcB Protein D3H65_RS25285 ENOG4105J5G Transferase hexapeptide repeat containing protein D3H65_RS25310 ENOG4105EY8 ABC transporter D3H65_RS25335 ENOG4105C1B dTDP-glucose 4-6-dehydratase D3H65_RS25345 ENOG4107S6X Glycosyl transferase, family 2 D3H65_RS25350 ENOG4107SWE Methyltransferase D3H65_RS25355 ENOG4108I69 Glycosyl transferases group 1 D3H65_RS25360 ENOG4105CPK Glycosyl transferase (Group 1 D3H65_RS25380 ENOG4108FN7 Aldo keto reductase D3H65_RS25400 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) D3H65_RS25405 ENOG4105K64 Glycosyl transferase, family 2 D3H65_RS25425 ENOG4105CAQ asparagine synthetase D3H65_RS25435 ENOG4108Z90 colanic acid biosynthesis acetyltransferase wcaF D3H65_RS25445 ENOG4105C0K Gdp-mannose 4,6-dehydratase D3H65_RS25450 ENOG4105C30 Nad-dependent epimerase dehydratase D3H65_RS25455 ENOG4108RB3 Capsular polysaccharide biosynthesis protein D3H65_RS25460 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase D3H65_RS25465 ENOG4105D52 delta-aminolevulinic acid dehydratase D3H65_RS25470 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) D3H65_RS25480 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) D3H65_RS25490 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) D3H65_RS25495 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) D3H65_RS25500 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) D3H65_RS25515 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) D3H65_RS25525 ENOG4105DY9 regulatoR D3H65_RS25530 ENOG4108HRK Histidine kinase D3H65_RS25535 ENOG4105C1B dTDP-glucose 4-6-dehydratase D3H65_RS25540 ENOG4105UBK short-chain dehydrogenase reductase D3H65_RS25550 ENOG4105BZ1 (ABC) transporter D3H65_RS25555 ENOG4105H4N Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) D3H65_RS25570 ENOG4105CV1 Transketolase (EC 2.2.1.1) D3H65_RS25575 ENOG4105ESV Glycosyl transferase, family 4 D3H65_RS25580 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) D3H65_RS25585 ENOG4105CSR polyphosphate kinase 2 D3H65_RS25590 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) D3H65_RS25600 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) D3H65_RS25610 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) D3H65_RS25615 ENOG4108HRK Histidine kinase D3H65_RS25620 ENOG4108NEV two component transcriptional regulator, LytTR family D3H65_RS25650 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) D3H65_RS25670 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) D3H65_RS25695 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) D3H65_RS25705 ENOG41060VI Involved in DNA repair and RecF pathway recombination (By similarity) D3H65_RS25720 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS25780 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) D3H65_RS25785 ENOG4105C0H protease D3H65_RS25790 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) D3H65_RS25795 ENOG4105DR5 peptidase D3H65_RS25805 ENOG4105D05 Receptor D3H65_RS25815 ENOG4107R4I Periplasmic binding protein D3H65_RS25820 ENOG4105EHG Permease protein D3H65_RS25825 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) D3H65_RS25840 ENOG4107X2D transcriptional regulator, merr family D3H65_RS25860 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) D3H65_RS25870 ENOG4107RMN lycopene cyclase D3H65_RS25880 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family D3H65_RS25895 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) D3H65_RS25900 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) D3H65_RS25905 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) D3H65_RS25920 ENOG4105BZU Histidine kinase D3H65_RS25945 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS25975 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS25990 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein D3H65_RS26000 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) D3H65_RS26005 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) D3H65_RS26040 ENOG4105E0K tonB-dependent siderophore receptor D3H65_RS26045 ENOG4107R7I amino acid D3H65_RS26050 ENOG4105C28 cystathionine D3H65_RS26070 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) D3H65_RS26075 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase D3H65_RS26085 ENOG4105CSA Coproporphyrinogen iii oxidase D3H65_RS26105 ENOG4105C7Z Conserved Protein D3H65_RS26110 ENOG4105E6M Sulphatase-modifying factor protein D3H65_RS26130 ENOG4105C8F Beta-lactamase domain protein D3H65_RS26135 ENOG4105CJN penicillin-binding protein D3H65_RS26140 ENOG4105CNI cell division protein FtsW D3H65_RS26145 ENOG4105CJN penicillin-binding protein D3H65_RS26155 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) D3H65_RS26160 ENOG4105DFF Rod shape-determining protein mreb D3H65_RS26185 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) D3H65_RS26205 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) D3H65_RS26215 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase D3H65_RS26230 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) D3H65_RS26235 ENOG4105NWN ApaG protein D3H65_RS26245 ENOG4105DUX Transporter D3H65_RS26250 ENOG4105C12 Phosphoribosylglycinamide synthetase D3H65_RS26255 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) D3H65_RS26260 ENOG4108IUS Transketolase D3H65_RS26265 ENOG4105CMR udp-glucose 4-epimerase D3H65_RS26275 ENOG4107QXV Phosphate transporter D3H65_RS26325 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS26345 ENOG4108KAZ Involved in phosphonate degradation (By similarity) D3H65_RS26360 ENOG4108WIQ phosphoesterase PA-phosphatase related protein D3H65_RS26370 ENOG4105D64 Mechanosensitive ion channel D3H65_RS26375 ENOG4105BZU Histidine kinase D3H65_RS26380 ENOG4105DPZ Two component transcriptional regulator (Winged helix family D3H65_RS26390 ENOG4105BZ1 (ABC) transporter D3H65_RS26405 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) D3H65_RS26415 ENOG4107Z65 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) D3H65_RS26420 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) D3H65_RS26425 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) D3H65_RS26440 ENOG4108JA2 transcriptioN-repair coupling factor D3H65_RS26445 ENOG4105DP0 ferredoxin-NADP reductase D3H65_RS26455 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) D3H65_RS26470 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase D3H65_RS26475 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) D3H65_RS26480 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) D3H65_RS26490 ENOG4105CA0 peroxidase D3H65_RS26495 ENOG4108ZVT methylmalonyl-coA epimerase D3H65_RS26500 ENOG4105C3J Cysteine desulfurase D3H65_RS26515 ENOG4105DU1 integral membrane protein, terc D3H65_RS26520 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) D3H65_RS26525 ENOG4107T7F This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) D3H65_RS26540 ENOG4105D8V Glucose sorbosone dehydrogenase D3H65_RS26550 ENOG4105C9Q fumarate hydratase class II D3H65_RS26555 ENOG4105ETE Transcriptional regulator (LacI family D3H65_RS26580 ENOG4105E39 Enoyl-CoA hydratase D3H65_RS26600 ENOG4105D5P Methylmalonyl-coA mutase D3H65_RS26610 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) D3H65_RS26620 ENOG4108ZJ4 polysaccharide deacetylase D3H65_RS26630 ENOG4105F8V Hydrolase, tatD family D3H65_RS26640 ENOG41082IR Excinuclease ABC C subunit domain protein D3H65_RS26660 ENOG4105D1Z hydroxypyruvate reductase D3H65_RS26665 ENOG4105C6Z Gluconate D3H65_RS26695 ENOG4108ZF3 Phosphatase D3H65_RS26700 ENOG4105D9P serine threonine protein kinase D3H65_RS26705 ENOG4107QHZ cell cycle protein D3H65_RS26715 ENOG4105E6M Sulphatase-modifying factor protein D3H65_RS26755 ENOG4105BZU Histidine kinase D3H65_RS26765 ENOG4108JUA Transcriptional regulator D3H65_RS26780 ENOG4105EUB pirin domain protein D3H65_RS26785 ENOG4108RMU ferritin dps family protein D3H65_RS26795 ENOG4108YYC ycei family D3H65_RS26800 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase D3H65_RS26835 ENOG4108MYR Secreted protein D3H65_RS26920 ENOG4108M3J Dehydrogenase D3H65_RS26925 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) D3H65_RS26935 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) D3H65_RS26950 ENOG4105C8F Beta-lactamase domain protein D3H65_RS26955 ENOG4105DEU major facilitator superfamily D3H65_RS26960 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) D3H65_RS26970 ENOG4107RJ9 Cell division protein FtsX D3H65_RS26975 ENOG4105C8T Leucyl-tRNA synthetase D3H65_RS27030 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) D3H65_RS27050 ENOG4105D7A ATP-binding protein D3H65_RS27055 ENOG4105C9U ATP-dependent DNA helicase RecQ D3H65_RS27065 ENOG4105C59 p-type ATPase D3H65_RS27080 ENOG4105DA5 (ABC) transporter D3H65_RS27085 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) D3H65_RS27090 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) D3H65_RS27095 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) D3H65_RS27100 ENOG4105DCI Phosphohydrolase D3H65_RS27105 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family D3H65_RS27115 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) D3H65_RS27125 ENOG4105C1G acyl-Coa dehydrogenase D3H65_RS27130 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) D3H65_RS27135 ENOG4108N9J Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) D3H65_RS27140 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) D3H65_RS27150 ENOG4107V87 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase (By similarity) D3H65_RS27160 ENOG4108NEV two component transcriptional regulator, LytTR family D3H65_RS27180 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) D3H65_RS27185 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS27195 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis D3H65_RS27210 ENOG4105E4C Lytic transglycosylase catalytic D3H65_RS27215 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) D3H65_RS27220 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) D3H65_RS27225 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) D3H65_RS27230 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) D3H65_RS27235 ENOG4108IFH alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen D3H65_RS27290 ENOG4105CDU Replicative dna helicase D3H65_RS27310 ENOG4105EE5 Membrane protein terC D3H65_RS27315 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) D3H65_RS27320 ENOG4105CHU acetyl-coa acetyltransferase D3H65_RS27335 ENOG4105WH1 Two component transcriptional regulator luxr family D3H65_RS27340 ENOG4105BZU Histidine kinase D3H65_RS27345 ENOG4105D05 Receptor D3H65_RS27365 ENOG4105BZ1 (ABC) transporter D3H65_RS27380 ENOG4105ER6 polysaccharide biosynthesis protein D3H65_RS27405 ENOG4105CKK Glycosyl transferase, family 2 D3H65_RS27415 ENOG4108TJN glycosyl transferase group 1 D3H65_RS27435 ENOG4105C0P Mg chelatase subunit ChlI D3H65_RS27440 ENOG4105CD8 aminopeptidase N D3H65_RS27445 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) D3H65_RS27475 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) D3H65_RS27485 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) D3H65_RS27495 ENOG41065KQ synthase D3H65_RS27505 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B D3H65_RS27530 ENOG4105ECP epimerase D3H65_RS27545 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) D3H65_RS27560 ENOG4105C6E dna polymerase iii D3H65_RS27565 ENOG4107Z3H Transcriptional regulator, TetR family D3H65_RS27600 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) D3H65_RS27635 ENOG4105D3Q Sugar transferase D3H65_RS27675 ENOG4105EXC Acyl-transferase D3H65_RS27705 ENOG4105CQB FAD linked oxidase domain protein D3H65_RS27715 ENOG4108URH decarboxylase D3H65_RS27720 ENOG4108IA2 Sodium pantothenate symporter D3H65_RS27725 ENOG4108URH decarboxylase D3H65_RS27740 ENOG4108UGV hypoxanthine phosphoribosyltransferase D3H65_RS27745 ENOG4105CP2 von willebrand factor, type a D3H65_RS27750 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) D3H65_RS27755 ENOG4107XPB Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ D3H65_RS27770 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen D3H65_RS27795 ENOG4105CTD carboxy-peptidase D3H65_RS27845 ENOG4105EGD dinuclear metal center protein, YbgI family D3H65_RS27860 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) D3H65_RS27875 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH D3H65_RS27885 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) D3H65_RS27890 ENOG4108WBT adenosyltransferase D3H65_RS27895 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) D3H65_RS27900 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) D3H65_RS27905 ENOG4105C31 Tryptophanyl-tRNA synthetase D3H65_RS27910 ENOG4105ZMH deoxynucleoside kinase D3H65_RS27930 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase D3H65_RS27935 ENOG4107RAQ aminopeptidase D3H65_RS27940 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase D3H65_RS27975 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) D3H65_RS27985 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) D3H65_RS28020 ENOG4107QKA exodeoxyribonuclease V beta D3H65_RS28025 ENOG4105DSY exodeoxyribonuclease V, gamma D3H65_RS28030 ENOG4107QYX exodeoxyribonuclease v alpha D3H65_RS28035 ENOG4105NAE bifunctional deaminase-reductase domain protein D3H65_RS28045 ENOG4108Q35 Adenylate D3H65_RS28070 ENOG4105F27 Major Facilitator D3H65_RS28080 ENOG4105DZG Dehydrogenase D3H65_RS28085 ENOG4105EXC Acyl-transferase D3H65_RS28115 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS28135 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) D3H65_RS28215 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) D3H65_RS28325 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS28350 ENOG4108KPZ tonB-dependent Receptor D3H65_RS28400 ENOG4105CPC Aldo Keto reductase D3H65_RS28405 ENOG4105CI2 imidazolone-5-propionate hydrolase D3H65_RS28445 ENOG4106YN8 Prenyltransferase D3H65_RS28450 ENOG4105IQ5 FAD linked oxidase domain protein D3H65_RS28460 ENOG41083B3 HAD-superfamily subfamily IB hydrolase D3H65_RS28500 ENOG4108UJU UPF0301 protein D3H65_RS28510 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) D3H65_RS28520 ENOG4107YM1 mraZ protein D3H65_RS28525 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) D3H65_RS28535 ENOG4105CJN penicillin-binding protein D3H65_RS28540 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) D3H65_RS28545 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) D3H65_RS28550 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) D3H65_RS28560 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) D3H65_RS28565 ENOG4105DFU Cell wall formation (By similarity) D3H65_RS28575 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) D3H65_RS28580 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) D3H65_RS28590 ENOG4105ECP epimerase D3H65_RS28600 ENOG4105DA5 (ABC) transporter D3H65_RS28625 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) D3H65_RS28645 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A D3H65_RS28660 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A D3H65_RS28665 ENOG4105C5Q Transcriptional regulator D3H65_RS28680 ENOG4105DFH Transport of potassium into the cell (By similarity) D3H65_RS28695 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I D3H65_RS28740 ENOG4108NEV two component transcriptional regulator, LytTR family D3H65_RS28750 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) D3H65_RS28755 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) D3H65_RS28780 ENOG4108IUX (ABC) transporter D3H65_RS28785 ENOG4105DZ0 fad dependent oxidoreductase D3H65_RS28790 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) D3H65_RS28835 ENOG4108KB1 transcriptional regulator, arac family D3H65_RS28870 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) D3H65_RS28890 ENOG4106FN3 tellurium resistance protein D3H65_RS28900 ENOG4108M24 von Willebrand factor, type A D3H65_RS28945 ENOG4107TS3 membrane protein, TerC D3H65_RS28960 ENOG4105TNG K13735 adhesin invasin D3H65_RS28970 ENOG4105UYK outer membrane protein a D3H65_RS28975 ENOG4105D03 DNA-3-methyladenine glycosylase II D3H65_RS28980 ENOG4105C6T cysteine synthase D3H65_RS29005 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) D3H65_RS29010 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) D3H65_RS29015 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) D3H65_RS29020 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) D3H65_RS29025 ENOG4105CM2 brancheD-chain amino acid aminotransferase D3H65_RS29035 ENOG4105C7K acetolactate synthase D3H65_RS29045 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase D3H65_RS29050 ENOG4105C7B Threonine dehydratase D3H65_RS29085 ENOG4105BZU Histidine kinase D3H65_RS29100 ENOG4105CFH Aspartokinase D3H65_RS29105 ENOG4107RDY Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) D3H65_RS29115 ENOG4105D6E homoserine dehydrogenase D3H65_RS29120 ENOG4105C28 cystathionine D3H65_RS29135 ENOG4105F37 PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX. PSI is a plastocyanin cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn. Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin or cytochrome c6 D3H65_RS29140 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) D3H65_RS29145 ENOG4108ZIE 5 nucleotidase deoxy cytosolic type C D3H65_RS29160 ENOG4107YB6 acetyltransferase, (GNAT) family D3H65_RS29165 ENOG4105D1H recombination factor protein RarA D3H65_RS29190 ENOG4105WH1 Two component transcriptional regulator luxr family D3H65_RS29205 ENOG4105E63 Pfam:DUF178 D3H65_RS29210 ENOG4108UIH futalosine nucleosidase D3H65_RS29225 ENOG4105EUJ GTP cyclohydrolase i D3H65_RS29230 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase D3H65_RS29245 ENOG4105C28 cystathionine D3H65_RS29250 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) D3H65_RS29255 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) D3H65_RS29275 ENOG4105EMU Dehydrogenase D3H65_RS29285 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) D3H65_RS29295 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) D3H65_RS29300 ENOG4105C79 DNA protecting protein DprA D3H65_RS29305 ENOG4105CDV Ompa motb domain protein D3H65_RS29310 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) D3H65_RS29320 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) D3H65_RS29335 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS29360 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS29375 ENOG4105W5Q DNA repair protein (RadC D3H65_RS29380 ENOG4105C5T Phosphoribosyl pyrophosphate synthase D3H65_RS29385 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) D3H65_RS29390 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) D3H65_RS29395 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase D3H65_RS29400 ENOG4105CPP Dehydrogenase, E1 component D3H65_RS29415 ENOG4106HBX Transcriptional Regulator AraC Family D3H65_RS29470 ENOG4107SET aldo keto reductase D3H65_RS29475 ENOG4105BZU Histidine kinase D3H65_RS29485 ENOG4105C1P efflux transporter, rnd family, mfp subunit D3H65_RS29495 ENOG4105CGS Alpha-glucosidase D3H65_RS29500 ENOG4105DY9 regulatoR D3H65_RS29505 ENOG4108HRK Histidine kinase D3H65_RS29530 ENOG4105CHR reductase D3H65_RS29535 ENOG4105ETE Transcriptional regulator (LacI family D3H65_RS29545 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS29555 ENOG4105D0H Alpha-glucuronidase (EC 3.2.1.139) D3H65_RS29560 ENOG4105ETE Transcriptional regulator (LacI family D3H65_RS29565 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) D3H65_RS29610 ENOG4105EP8 Glycosyl Hydrolase Family 88 D3H65_RS29700 ENOG4105CPC Aldo Keto reductase D3H65_RS29710 ENOG4105DQR SNARE associated Golgi D3H65_RS29715 ENOG4105EE5 Membrane protein terC D3H65_RS29720 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) D3H65_RS29770 ENOG4105EKC D3H65_RS29775 ENOG4105CKD glutathione-regulated potassium-efflux system protein D3H65_RS29780 ENOG4107QM2 Aldo Keto reductase D3H65_RS29820 ENOG4107RNH Outer membrane receptor FepA D3H65_RS29845 ENOG4105CWX Alpha-1,2-mannosidase D3H65_RS29850 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase D3H65_RS29855 ENOG4105CNT hydrolase family 2 D3H65_RS29965 ENOG4105DHQ Histidine kinase D3H65_RS29970 ENOG4105XJC Two component transcriptional regulator (Winged helix family D3H65_RS29980 ENOG4105E0M Sulfatase D3H65_RS29990 ENOG4106CKV Pap2 superfamily protein D3H65_RS29995 ENOG4107QYX exodeoxyribonuclease v alpha D3H65_RS30010 ENOG4105BZU Histidine kinase D3H65_RS30020 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) D3H65_RS30025 ENOG4105PGM cation diffusion facilitator family transporter D3H65_RS30030 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) D3H65_RS30035 ENOG4105KVH Transcriptional regulator D3H65_RS30060 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) D3H65_RS30080 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS30095 ENOG4105VRS hydrolase family 18 D3H65_RS30100 ENOG4105DQX Zinc finger domain D3H65_RS30135 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) D3H65_RS30145 ENOG4105C54 Major Facilitator superfamily D3H65_RS30155 ENOG4105KVH Transcriptional regulator D3H65_RS30170 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS30190 ENOG41063TF transcriptional regulator (AraC D3H65_RS30195 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS30210 ENOG4107HQ7 repeat protein D3H65_RS30215 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) D3H65_RS30235 ENOG4108YYC ycei family D3H65_RS30260 ENOG4105KME endoribonuclease L-psp D3H65_RS30280 ENOG4105W4W Transcriptional regulator D3H65_RS30290 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS30320 ENOG4105E1F short-chain dehydrogenase reductase D3H65_RS30340 ENOG4105C09 Bile acid D3H65_RS30345 ENOG41069H0 dihydroorotase EC 3.5.2.3 D3H65_RS30350 ENOG4105KME endoribonuclease L-psp D3H65_RS30355 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) D3H65_RS30360 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) D3H65_RS30365 ENOG4105DZG Dehydrogenase D3H65_RS30380 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS30415 ENOG4106UX7 integral membrane protein D3H65_RS30420 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) D3H65_RS30425 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) D3H65_RS30435 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate D3H65_RS30445 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) D3H65_RS30460 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) D3H65_RS30465 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) D3H65_RS30470 ENOG4105W8H transhydrogenase (subunit alpha D3H65_RS30475 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) D3H65_RS30480 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B D3H65_RS30490 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) D3H65_RS30495 ENOG4105EHZ conserved protein UCP016719 D3H65_RS30500 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase D3H65_RS30515 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) D3H65_RS30520 ENOG4105CDV Ompa motb domain protein D3H65_RS30525 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase D3H65_RS30530 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS30545 ENOG4107QX8 SPFH domain, Band 7 family protein D3H65_RS30550 ENOG4105M8K biopolymer transport protein D3H65_RS30560 ENOG4105IQ5 FAD linked oxidase domain protein D3H65_RS30565 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) D3H65_RS30570 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) D3H65_RS30575 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein D3H65_RS30580 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase D3H65_RS30620 ENOG4105E5H Transposase D3H65_RS30705 ENOG4108QXE glycerophosphoryl diester phosphodiesterase D3H65_RS30710 ENOG4105CHR reductase D3H65_RS30720 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) D3H65_RS30725 ENOG4105SKN orotidine 5''-phosphate decarboxylase D3H65_RS30745 ENOG4105EMN RNA polymerase sigma factor D3H65_RS30760 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) D3H65_RS30770 ENOG4105BZU Histidine kinase D3H65_RS30775 ENOG4105CNU cell division protein FtsK D3H65_RS30785 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase D3H65_RS30790 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) D3H65_RS30800 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) D3H65_RS30810 ENOG4107RAN Peptidase, M16 D3H65_RS30835 ENOG4105EIE fructose-bisphosphate aldolase D3H65_RS30840 ENOG4105D2N Aldolase D3H65_RS30850 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase D3H65_RS30875 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) D3H65_RS30880 ENOG4108EE5 Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) D3H65_RS30900 ENOG4105BZM domain protein D3H65_RS30905 ENOG4105BZU Histidine kinase D3H65_RS30940 ENOG4105EMN RNA polymerase sigma factor D3H65_RS30950 ENOG4105CN1 protease D3H65_RS30960 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate D3H65_RS30995 ENOG4105CQC Prephenate dehydratase D3H65_RS31000 ENOG4105CHM Aminotransferase D3H65_RS31010 ENOG4105C1J atp-dependent rna helicase D3H65_RS31015 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase D3H65_RS31025 ENOG4105D49 3-dehydroquinate synthase D3H65_RS31035 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase D3H65_RS31050 ENOG4105DIT ErfK YbiS YcfS YnhG family protein D3H65_RS31055 ENOG4105K6T rare lipoprotein A D3H65_RS31060 ENOG4105KCK Peptidoglycan-associated lipoprotein D3H65_RS31065 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) D3H65_RS31100 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) D3H65_RS31105 ENOG4105C19 ABC transporter D3H65_RS31110 ENOG4105C1P efflux transporter, rnd family, mfp subunit D3H65_RS31125 ENOG4105DJV ribulose-phosphate 3-epimerase D3H65_RS31150 ENOG4105C2F Histidine kinase D3H65_RS31155 ENOG4108NEV two component transcriptional regulator, LytTR family D3H65_RS31165 ENOG4105CIH Imidazole acetol-phosphate transaminase D3H65_RS31170 ENOG4105C2F Histidine kinase D3H65_RS31175 ENOG4108NEV two component transcriptional regulator, LytTR family D3H65_RS31185 ENOG4105FDR Membrane D3H65_RS31205 ENOG4108RF1 Protein of unknown function DUF2625 D3H65_RS31210 ENOG4105F1J Homogentisate 1,2-dioxygenase D3H65_RS31215 ENOG41066YJ Beta-lactamase D3H65_RS31235 ENOG4105D0S secretion protein (HlyD D3H65_RS31240 ENOG4105CJ1 ABC, transporter D3H65_RS31245 ENOG4105CJ1 ABC, transporter D3H65_RS31250 ENOG4107QWP ABC-2 type transporter D3H65_RS31255 ENOG4107QWP ABC-2 type transporter D3H65_RS31265 ENOG4105CW7 secretion protein, HlyD family D3H65_RS31275 ENOG4107S9F NmrA family D3H65_RS31285 ENOG4108FN7 Aldo keto reductase D3H65_RS31295 ENOG4105Y7M Transcriptional regulator, TetR family D3H65_RS31300 ENOG4105F27 Major Facilitator D3H65_RS31310 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) D3H65_RS31315 ENOG410864M 50S ribosomal protein L36 D3H65_RS31320 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits D3H65_RS31325 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) D3H65_RS31330 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) D3H65_RS31335 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) D3H65_RS31340 ENOG4108ZT0 50S ribosomal protein l17 D3H65_RS31345 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain D3H65_RS31350 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) D3H65_RS31360 ENOG4107QKV phosphomannomutase D3H65_RS31420 ENOG4107QI6 Cysteine desulfurase D3H65_RS31430 ENOG4105CMG Carbohydrate kinase D3H65_RS31445 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) D3H65_RS31465 ENOG4108S4H thioesterase Superfamily protein D3H65_RS31470 ENOG4105DTQ mandelate racemase muconate lactonizing D3H65_RS31480 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase D3H65_RS31485 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) D3H65_RS31500 ENOG4107SYN Glycosyl hydrolases family 43 D3H65_RS31520 ENOG4105E2D ec 3.2.1.52 D3H65_RS31525 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate D3H65_RS31545 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS31550 ENOG4107EDW L-fucose operon activator D3H65_RS31560 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) D3H65_RS31590 ENOG4105E18 UPF0276 protein D3H65_RS31610 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) D3H65_RS31660 ENOG4105C7R Atpase associated with various cellular activities aaa_3 D3H65_RS31670 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) D3H65_RS31680 ENOG4108RWN rrna methyltransferase D3H65_RS31685 ENOG4107RBB ABC transporter, permease D3H65_RS31700 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) D3H65_RS31710 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) D3H65_RS31720 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) D3H65_RS31725 ENOG41090A1 ferritin D3H65_RS31740 ENOG4107RAQ aminopeptidase D3H65_RS31760 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase D3H65_RS31810 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) D3H65_RS31825 ENOG4108KPZ tonB-dependent Receptor D3H65_RS31830 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) D3H65_RS31845 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) D3H65_RS31850 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) D3H65_RS31910 ENOG4105DUM transcriptional regulator, lysR family D3H65_RS31920 ENOG4105E2D ec 3.2.1.52 D3H65_RS31940 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) D3H65_RS31945 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) D3H65_RS31950 ENOG4105CIH Imidazole acetol-phosphate transaminase D3H65_RS31970 ENOG4105ECC imidazole-glycerol-phosphate dehydratase D3H65_RS31975 ENOG410830R acetyltransferase D3H65_RS31985 ENOG4105CRQ synthase (Component I) D3H65_RS31990 ENOG4105DDQ anthranilate synthase D3H65_RS31995 ENOG4107RI6 Anthranilate phosphoribosyltransferase D3H65_RS32000 ENOG4105DK0 Indole-3-glycerol phosphate synthase D3H65_RS32005 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase D3H65_RS32010 ENOG4108Z7F N-acetyltransferase D3H65_RS32015 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) D3H65_RS32020 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) D3H65_RS32025 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) D3H65_RS32030 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase D3H65_RS32035 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) D3H65_RS32045 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase D3H65_RS32050 ENOG4108IFH alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen D3H65_RS32065 ENOG4108JQC penicillin-binding protein 1A D3H65_RS32095 ENOG4105KY5 gCN5-related N-acetyltransferase D3H65_RS32105 ENOG4105CMV Succinyl-CoA synthetase subunit beta D3H65_RS32200 ENOG4105E5K Alpha-amylase D3H65_RS32205 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) D3H65_RS32210 ENOG4105CYX Short-chain dehydrogenase reductase Sdr D3H65_RS32220 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) D3H65_RS32225 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family D3H65_RS32235 ENOG4105BZU Histidine kinase D3H65_RS32245 ENOG4105FDF Could be involved in DNA repair (By similarity) D3H65_RS32250 ENOG4105DQE DNA ligase D3H65_RS32290 ENOG4107Y70 Heat shock protein D3H65_RS32325 ENOG4105DCG PHP domain protein D3H65_RS32330 ENOG4105K46 50S ribosomal protein l27 D3H65_RS32335 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) D3H65_RS32345 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) D3H65_RS32350 ENOG4105DZP Membrane-associated zinc metalloprotease D3H65_RS32375 ENOG4105NAE bifunctional deaminase-reductase domain protein D3H65_RS32405 ENOG4107TXC Transcriptional regulator D3H65_RS32435 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein D3H65_RS32440 ENOG4105KVH Transcriptional regulator D3H65_RS32450 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) D3H65_RS32475 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS32490 ENOG4105C5H ABC transporter D3H65_RS32520 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) D3H65_RS32550 ENOG4105C27 TonB-dependent Receptor Plug D3H65_RS32565 ENOG4105EP8 Glycosyl Hydrolase Family 88 D3H65_RS32610 ENOG4105CA0 peroxidase D3H65_RS32625 ENOG4105D05 Receptor D3H65_RS32660 ENOG4108HRK Histidine kinase