locus-tag	class	description
D3H65_RS00005	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D3H65_RS00010	COG3279	Response regulator of the LytR AlgR family
D3H65_RS00015	COG3275	phosphorelay sensor kinase activity
D3H65_RS00040	COG0277	FAD linked oxidase domain protein
D3H65_RS00040	COG0247	lactate metabolic process
D3H65_RS00045	COG0232	Belongs to the dGTPase family. Type 2 subfamily
D3H65_RS00085	COG0640	Transcriptional regulator
D3H65_RS00090	COG4206	TonB-dependent receptor
D3H65_RS00090	COG1629	transport
D3H65_RS00110	COG2855	membrane
D3H65_RS00120	COG3275	phosphorelay sensor kinase activity
D3H65_RS00125	COG3279	Response regulator of the LytR AlgR family
D3H65_RS00135	COG3507	Belongs to the glycosyl hydrolase 43 family
D3H65_RS00145	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
D3H65_RS00150	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
D3H65_RS00180	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
D3H65_RS00185	COG3608	succinylglutamate desuccinylase aspartoacylase
D3H65_RS00185	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
D3H65_RS00195	COG2124	cytochrome p450
D3H65_RS00200	COG0640	Transcriptional regulator
D3H65_RS00205	COG1028	Short-chain dehydrogenase reductase Sdr
D3H65_RS00210	COG0673	inositol 2-dehydrogenase activity
D3H65_RS00215	COG2996	Protein conserved in bacteria
D3H65_RS00220	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D3H65_RS00225	COG1733	regulation of RNA biosynthetic process
D3H65_RS00255	COG0644	oxidoreductase
D3H65_RS00260	COG0753	catalase activity
D3H65_RS00265	COG3275	phosphorelay sensor kinase activity
D3H65_RS00275	COG3279	Response regulator of the LytR AlgR family
D3H65_RS00285	COG1028	Short-chain dehydrogenase reductase Sdr
D3H65_RS00290	COG1733	regulation of RNA biosynthetic process
D3H65_RS00325	COG3507	Belongs to the glycosyl hydrolase 43 family
D3H65_RS00365	COG2160	L-arabinose isomerase activity
D3H65_RS00375	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D3H65_RS00415	COG5002	protein histidine kinase activity
D3H65_RS00415	COG0784	Response regulator, receiver
D3H65_RS00420	COG0038	chloride channel
D3H65_RS00425	COG2197	response regulator
D3H65_RS00470	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D3H65_RS00560	COG1595	DNA-templated transcription, initiation
D3H65_RS00570	COG0798	PFAM Bile acid sodium symporter
D3H65_RS00575	COG2226	methyltransferase
D3H65_RS00585	COG3279	Response regulator of the LytR AlgR family
D3H65_RS00605	COG1819	glycosyl
D3H65_RS00660	COG0587	DNA-directed DNA polymerase activity
D3H65_RS00680	COG1278	Cold shock
D3H65_RS00685	COG0724	RNA recognition motif
D3H65_RS00690	COG2226	methyltransferase
D3H65_RS00695	COG2169	Transcriptional regulator
D3H65_RS00740	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D3H65_RS00745	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
D3H65_RS00755	COG0432	Pfam Uncharacterised protein family UPF0047
D3H65_RS00765	COG4251	negative regulation of phosphorylation
D3H65_RS00785	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D3H65_RS00795	COG1472	Belongs to the glycosyl hydrolase 3 family
D3H65_RS00800	COG1349	DNA-binding transcription factor activity
D3H65_RS00820	COG2610	gluconate transmembrane transporter activity
D3H65_RS00900	COG2186	Transcriptional regulator
D3H65_RS00945	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D3H65_RS00950	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D3H65_RS01015	COG3279	Response regulator of the LytR AlgR family
D3H65_RS01030	COG3956	TIGRFAM MazG family protein
D3H65_RS01065	COG1858	cytochrome C peroxidase
D3H65_RS01090	COG3158	transport of potassium into the cell
D3H65_RS01100	COG2217	Heavy metal translocating P-type atpase
D3H65_RS01110	COG4977	sequence-specific DNA binding
D3H65_RS01110	COG1917	Cupin 2, conserved barrel domain protein
D3H65_RS01185	COG0842	Transport permease protein
D3H65_RS01190	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D3H65_RS01200	COG0471	metal ion transport
D3H65_RS01210	COG2201	protein-glutamate methylesterase activity
D3H65_RS01215	COG4251	negative regulation of phosphorylation
D3H65_RS01230	COG0640	Transcriptional regulator
D3H65_RS01255	COG1058	Belongs to the CinA family
D3H65_RS01255	COG1546	Belongs to the CinA family
D3H65_RS01265	COG0784	Response regulator, receiver
D3H65_RS01270	COG0784	Response regulator, receiver
D3H65_RS01270	COG2205	protein histidine kinase activity
D3H65_RS01275	COG4251	negative regulation of phosphorylation
D3H65_RS01280	COG2816	NAD+ diphosphatase activity
D3H65_RS01295	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
D3H65_RS01300	COG0813	purine-nucleoside phosphorylase activity
D3H65_RS01315	COG0210	DNA helicase
D3H65_RS01375	COG0277	FAD linked oxidase domain protein
D3H65_RS01395	COG2201	protein-glutamate methylesterase activity
D3H65_RS01405	COG3546	catalase activity
D3H65_RS01415	COG4251	negative regulation of phosphorylation
D3H65_RS01455	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D3H65_RS01470	COG3685	Protein conserved in bacteria
D3H65_RS01475	COG1028	Short-chain dehydrogenase reductase Sdr
D3H65_RS01485	COG1764	response to oxidative stress
D3H65_RS01495	COG0596	Alpha beta hydrolase
D3H65_RS01500	COG0300	oxidoreductase activity
D3H65_RS01525	COG1621	beta-fructofuranosidase activity
D3H65_RS01570	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
D3H65_RS01630	COG0577	efflux transmembrane transporter activity
D3H65_RS01645	COG1506	peptidase
D3H65_RS01645	COG0823	Involved in the tonB-independent uptake of proteins
D3H65_RS01660	COG1629	transport
D3H65_RS01660	COG4206	TonB-dependent receptor
D3H65_RS01675	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
D3H65_RS01690	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
D3H65_RS01710	COG0640	Transcriptional regulator
D3H65_RS01720	COG4948	Mandelate Racemase Muconate Lactonizing
D3H65_RS01755	COG1028	Short-chain dehydrogenase reductase Sdr
D3H65_RS01760	COG2814	Major facilitator Superfamily
D3H65_RS01765	COG0596	Alpha beta hydrolase
D3H65_RS01820	COG4206	TonB-dependent receptor
D3H65_RS01820	COG1629	transport
D3H65_RS01840	COG0180	Tryptophanyl-tRNA synthetase
D3H65_RS01845	COG4682	membrane
D3H65_RS01865	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D3H65_RS01870	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
D3H65_RS01880	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
D3H65_RS01895	COG0037	tRNA processing
D3H65_RS01905	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
D3H65_RS01910	COG0628	permease
D3H65_RS01950	COG0210	DNA helicase
D3H65_RS01965	COG1537	nuclear-transcribed mRNA catabolic process, no-go decay
D3H65_RS01975	COG4585	Histidine kinase
D3H65_RS02020	COG3458	cephalosporin-C deacetylase activity
D3H65_RS02055	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D3H65_RS02080	COG4977	sequence-specific DNA binding
D3H65_RS02090	COG2814	Major facilitator Superfamily
D3H65_RS02125	COG3275	phosphorelay sensor kinase activity
D3H65_RS02160	COG0673	inositol 2-dehydrogenase activity
D3H65_RS02185	COG3275	phosphorelay sensor kinase activity
D3H65_RS02190	COG3279	Response regulator of the LytR AlgR family
D3H65_RS02195	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D3H65_RS02200	COG0823	Involved in the tonB-independent uptake of proteins
D3H65_RS02215	COG1629	transport
D3H65_RS02215	COG4206	TonB-dependent receptor
D3H65_RS02225	COG1446	asparaginase
D3H65_RS02230	COG1132	(ABC) transporter
D3H65_RS02240	COG4585	Histidine kinase
D3H65_RS02255	COG1595	DNA-templated transcription, initiation
D3H65_RS02260	COG3279	Response regulator of the LytR AlgR family
D3H65_RS02265	COG3275	phosphorelay sensor kinase activity
D3H65_RS02295	COG3360	Dodecin
D3H65_RS02315	COG2814	Major facilitator Superfamily
D3H65_RS02340	COG3279	Response regulator of the LytR AlgR family
D3H65_RS02345	COG3275	phosphorelay sensor kinase activity
D3H65_RS02370	COG2197	response regulator
D3H65_RS02385	COG0667	Aldo Keto reductase
D3H65_RS02395	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D3H65_RS02395	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
D3H65_RS02440	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D3H65_RS02440	COG0574	Belongs to the PEP-utilizing enzyme family
D3H65_RS02500	COG1028	Short-chain dehydrogenase reductase Sdr
D3H65_RS02505	COG0179	Fumarylacetoacetate (FAA) hydrolase
D3H65_RS02510	COG1556	Lactate utilization protein
D3H65_RS02515	COG1139	Iron-sulfur cluster binding protein
D3H65_RS02520	COG0247	lactate metabolic process
D3H65_RS02525	COG1028	Short-chain dehydrogenase reductase Sdr
D3H65_RS02530	COG0738	Major facilitator superfamily
D3H65_RS02540	COG1629	transport
D3H65_RS02540	COG4206	TonB-dependent receptor
D3H65_RS02555	COG3250	beta-galactosidase activity
D3H65_RS02640	COG1629	transport
D3H65_RS02640	COG4206	TonB-dependent receptor
D3H65_RS02670	COG1525	nuclease
D3H65_RS02675	COG1278	Cold shock
D3H65_RS02680	COG0494	nUDIX hydrolase
D3H65_RS02690	COG3275	phosphorelay sensor kinase activity
D3H65_RS02700	COG1609	Transcriptional regulator
D3H65_RS02770	COG2207	Transcriptional regulator
D3H65_RS02770	COG0662	Cupin 2, conserved barrel domain protein
D3H65_RS02780	COG2721	sulfolactate sulfo-lyase activity
D3H65_RS02785	COG1312	Catalyzes the dehydration of D-mannonate
D3H65_RS02795	COG2186	Transcriptional regulator
D3H65_RS02800	COG2223	nitrite transmembrane transporter activity
D3H65_RS02805	COG0363	glucosamine-6-phosphate deaminase activity
D3H65_RS02830	COG0823	Involved in the tonB-independent uptake of proteins
D3H65_RS02835	COG0823	Involved in the tonB-independent uptake of proteins
D3H65_RS02840	COG3525	Glycosyl hydrolase, family 20, catalytic domain
D3H65_RS02865	COG1446	asparaginase
D3H65_RS02870	COG3142	Participates in the control of copper homeostasis
D3H65_RS02900	COG0205	6-phosphofructokinase activity
D3H65_RS02905	COG1505	serine-type exopeptidase activity
D3H65_RS02910	COG1091	dTDP-4-dehydrorhamnose reductase activity
D3H65_RS02935	COG2235	arginine
D3H65_RS02940	COG1764	response to oxidative stress
D3H65_RS02955	COG3239	Fatty acid desaturase
D3H65_RS02960	COG0724	RNA recognition motif
D3H65_RS02990	COG3250	beta-galactosidase activity
D3H65_RS03010	COG0673	inositol 2-dehydrogenase activity
D3H65_RS03040	COG3422	double-strand break repair
D3H65_RS03085	COG1027	Aspartate ammonia-lyase
D3H65_RS03095	COG0662	Cupin 2, conserved barrel domain protein
D3H65_RS03115	COG0237	dephospho-CoA kinase activity
D3H65_RS03120	COG1862	Preprotein translocase
D3H65_RS03130	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D3H65_RS03135	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
D3H65_RS03155	COG0071	Belongs to the small heat shock protein (HSP20) family
D3H65_RS03165	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
D3H65_RS03180	COG1666	GTP binding
D3H65_RS03185	COG0254	rRNA binding
D3H65_RS03190	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
D3H65_RS03195	COG0149	triose-phosphate isomerase activity
D3H65_RS03220	COG0010	Belongs to the arginase family
D3H65_RS03240	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
D3H65_RS03240	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
D3H65_RS03250	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
D3H65_RS03255	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
D3H65_RS03260	COG0297	glycogen (starch) synthase activity
D3H65_RS03270	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
D3H65_RS03280	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D3H65_RS03285	COG1473	amidohydrolase
D3H65_RS03305	COG0673	inositol 2-dehydrogenase activity
D3H65_RS03310	COG0018	arginyl-trna synthetase
D3H65_RS03330	COG0443	Heat shock 70 kDa protein
D3H65_RS03340	COG0577	efflux transmembrane transporter activity
D3H65_RS03345	COG1136	(ABC) transporter
D3H65_RS03345	COG0577	efflux transmembrane transporter activity
D3H65_RS03365	COG0531	amino acid
D3H65_RS03390	COG0545	Peptidyl-prolyl cis-trans isomerase
D3H65_RS03395	COG1760	l-serine dehydratase
D3H65_RS03410	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
D3H65_RS03415	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D3H65_RS03440	COG0791	NLP P60 protein
D3H65_RS03465	COG0747	negative chemotaxis
D3H65_RS03470	COG0596	Alpha beta hydrolase
D3H65_RS03475	COG3279	Response regulator of the LytR AlgR family
D3H65_RS03520	COG4206	TonB-dependent receptor
D3H65_RS03520	COG1629	transport
D3H65_RS03525	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
D3H65_RS03535	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
D3H65_RS03555	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D3H65_RS03560	COG1193	negative regulation of DNA recombination
D3H65_RS03590	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
D3H65_RS03595	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
D3H65_RS03620	COG1629	transport
D3H65_RS03620	COG4206	TonB-dependent receptor
D3H65_RS03675	COG3525	Glycosyl hydrolase, family 20, catalytic domain
D3H65_RS03680	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
D3H65_RS03680	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
D3H65_RS03690	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D3H65_RS03695	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D3H65_RS03710	COG0681	Belongs to the peptidase S26 family
D3H65_RS03715	COG0295	cytidine deaminase activity
D3H65_RS03735	COG1629	transport
D3H65_RS03735	COG4206	TonB-dependent receptor
D3H65_RS03795	COG1136	(ABC) transporter
D3H65_RS03795	COG0577	efflux transmembrane transporter activity
D3H65_RS03815	COG2318	DinB family
D3H65_RS03840	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D3H65_RS03865	COG0837	glucose binding
D3H65_RS03870	COG0793	Belongs to the peptidase S41A family
D3H65_RS03885	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D3H65_RS03885	COG2207	Transcriptional regulator
D3H65_RS03945	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
D3H65_RS03945	COG0116	Belongs to the methyltransferase superfamily
D3H65_RS03970	COG4977	sequence-specific DNA binding
D3H65_RS04040	COG2217	Heavy metal translocating P-type atpase
D3H65_RS04055	COG0406	alpha-ribazole phosphatase activity
D3H65_RS04110	COG1595	DNA-templated transcription, initiation
D3H65_RS04120	COG1629	transport
D3H65_RS04120	COG4206	TonB-dependent receptor
D3H65_RS04125	COG1629	transport
D3H65_RS04125	COG4206	TonB-dependent receptor
D3H65_RS04180	COG0714	Associated with various cellular activities
D3H65_RS04215	COG1629	transport
D3H65_RS04215	COG4206	TonB-dependent receptor
D3H65_RS04335	COG3275	phosphorelay sensor kinase activity
D3H65_RS04395	COG2249	NAD(P)H dehydrogenase (quinone) activity
D3H65_RS04415	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D3H65_RS04480	COG4206	TonB-dependent receptor
D3H65_RS04480	COG1629	transport
D3H65_RS04500	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
D3H65_RS04525	COG0105	UTP biosynthetic process
D3H65_RS04535	COG0544	peptidyl-prolyl cis-trans isomerase activity
D3H65_RS04545	COG3275	phosphorelay sensor kinase activity
D3H65_RS04590	COG3279	Response regulator of the LytR AlgR family
D3H65_RS04600	COG0596	Alpha beta hydrolase
D3H65_RS04645	COG0303	'Molybdopterin
D3H65_RS04650	COG0730	response to heat
D3H65_RS04660	COG0314	molybdopterin synthase activity
D3H65_RS04665	COG0315	cyclic pyranopterin monophosphate synthase activity
D3H65_RS04665	COG0521	Mo-molybdopterin cofactor biosynthetic process
D3H65_RS04670	COG2205	protein histidine kinase activity
D3H65_RS04680	COG4206	TonB-dependent receptor
D3H65_RS04680	COG1629	transport
D3H65_RS04720	COG0243	molybdopterin cofactor binding
D3H65_RS04725	COG2223	nitrite transmembrane transporter activity
D3H65_RS04735	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D3H65_RS04735	COG2146	nitrite reductase [NAD(P)H] activity
D3H65_RS04740	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D3H65_RS04745	COG1648	precorrin-2 dehydrogenase activity
D3H65_RS04745	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D3H65_RS04760	COG3279	Response regulator of the LytR AlgR family
D3H65_RS04800	COG2223	nitrite transmembrane transporter activity
D3H65_RS04810	COG0745	RESPONSE REGULATOR receiver
D3H65_RS04815	COG5002	protein histidine kinase activity
D3H65_RS04830	COG0668	transmembrane transport
D3H65_RS04840	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
D3H65_RS04850	COG0697	spore germination
D3H65_RS04855	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D3H65_RS04905	COG1629	transport
D3H65_RS04905	COG4206	TonB-dependent receptor
D3H65_RS04910	COG4206	TonB-dependent receptor
D3H65_RS04910	COG1629	transport
D3H65_RS04960	COG0629	single-stranded DNA binding
D3H65_RS04980	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
D3H65_RS05000	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D3H65_RS05010	COG0492	ferredoxin-NADP+ reductase activity
D3H65_RS05025	COG2824	Alkylphosphonate utilization operon protein PhnA
D3H65_RS05055	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
D3H65_RS05065	COG0587	DNA-directed DNA polymerase activity
D3H65_RS05090	COG2169	Transcriptional regulator
D3H65_RS05095	COG2764	glyoxalase bleomycin resistance protein dioxygenase
D3H65_RS05115	COG1960	acyl-CoA dehydrogenase activity
D3H65_RS05140	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D3H65_RS05170	COG0316	Belongs to the HesB IscA family
D3H65_RS05195	COG1136	(ABC) transporter
D3H65_RS05195	COG0577	efflux transmembrane transporter activity
D3H65_RS05200	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D3H65_RS05230	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
D3H65_RS05240	COG4251	negative regulation of phosphorylation
D3H65_RS05255	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D3H65_RS05265	COG2133	pyrroloquinoline quinone binding
D3H65_RS05300	COG1741	Belongs to the pirin family
D3H65_RS05305	COG1629	transport
D3H65_RS05305	COG4206	TonB-dependent receptor
D3H65_RS05365	COG5492	domain, Protein
D3H65_RS05385	COG1609	Transcriptional regulator
D3H65_RS05390	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
D3H65_RS05395	COG1609	Transcriptional regulator
D3H65_RS05400	COG2267	carboxylic ester hydrolase activity
D3H65_RS05405	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D3H65_RS05415	COG1629	transport
D3H65_RS05415	COG4206	TonB-dependent receptor
D3H65_RS05460	COG1917	Cupin 2, conserved barrel domain protein
D3H65_RS05460	COG2169	Transcriptional regulator
D3H65_RS05470	COG1595	DNA-templated transcription, initiation
D3H65_RS05500	COG1522	sequence-specific DNA binding
D3H65_RS05505	COG2962	Rard protein
D3H65_RS05515	COG2837	iron assimilation
D3H65_RS05555	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D3H65_RS05575	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
D3H65_RS05620	COG1609	Transcriptional regulator
D3H65_RS05645	COG2207	Transcriptional regulator
D3H65_RS05720	COG1607	acyl-coa hydrolase
D3H65_RS05735	COG1649	PFAM Uncharacterised BCR, COG1649
D3H65_RS05775	COG4977	sequence-specific DNA binding
D3H65_RS05810	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D3H65_RS05850	COG1228	amidohydrolase
D3H65_RS05900	COG1131	(ABC) transporter
D3H65_RS05905	COG3275	phosphorelay sensor kinase activity
D3H65_RS05910	COG3279	Response regulator of the LytR AlgR family
D3H65_RS05920	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D3H65_RS05950	COG1846	Transcriptional regulator
D3H65_RS05955	COG3059	membrane
D3H65_RS05995	COG1595	DNA-templated transcription, initiation
D3H65_RS06005	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D3H65_RS06005	COG0519	Catalyzes the synthesis of GMP from XMP
D3H65_RS06015	COG1733	regulation of RNA biosynthetic process
D3H65_RS06020	COG3275	phosphorelay sensor kinase activity
D3H65_RS06055	COG0673	inositol 2-dehydrogenase activity
D3H65_RS06080	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D3H65_RS06220	COG1629	transport
D3H65_RS06220	COG4206	TonB-dependent receptor
D3H65_RS06225	COG0561	phosphatase activity
D3H65_RS06245	COG1082	Xylose isomerase domain protein TIM barrel
D3H65_RS06255	COG2814	Major facilitator Superfamily
D3H65_RS06305	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D3H65_RS06315	COG1201	RNA secondary structure unwinding
D3H65_RS06345	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
D3H65_RS06370	COG1629	transport
D3H65_RS06370	COG4206	TonB-dependent receptor
D3H65_RS06460	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D3H65_RS06485	COG1733	regulation of RNA biosynthetic process
D3H65_RS06505	COG1028	Short-chain dehydrogenase reductase Sdr
D3H65_RS06545	COG1629	transport
D3H65_RS06545	COG4206	TonB-dependent receptor
D3H65_RS06560	COG3940	Belongs to the glycosyl hydrolase 43 family
D3H65_RS06590	COG0673	inositol 2-dehydrogenase activity
D3H65_RS06610	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D3H65_RS06620	COG3876	Protein conserved in bacteria
D3H65_RS06635	COG0531	amino acid
D3H65_RS06775	COG4206	TonB-dependent receptor
D3H65_RS06775	COG1629	transport
D3H65_RS06800	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
D3H65_RS06810	COG1131	(ABC) transporter
D3H65_RS06820	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
D3H65_RS06825	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
D3H65_RS06835	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D3H65_RS06840	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D3H65_RS06850	COG3848	Pyruvate phosphate dikinase
D3H65_RS06850	COG0574	Belongs to the PEP-utilizing enzyme family
D3H65_RS06975	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D3H65_RS06995	COG2207	Transcriptional regulator
D3H65_RS06995	COG1917	Cupin 2, conserved barrel domain protein
D3H65_RS07000	COG2115	Belongs to the xylose isomerase family
D3H65_RS07020	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D3H65_RS07025	COG0300	oxidoreductase activity
D3H65_RS07045	COG0726	polysaccharide deacetylase
D3H65_RS07100	COG1132	(ABC) transporter
D3H65_RS07135	COG0346	lactoylglutathione lyase activity
D3H65_RS07155	COG3279	Response regulator of the LytR AlgR family
D3H65_RS07160	COG3275	phosphorelay sensor kinase activity
D3H65_RS07165	COG3275	phosphorelay sensor kinase activity
D3H65_RS07190	COG3279	Response regulator of the LytR AlgR family
D3H65_RS07200	COG0739	heme binding
D3H65_RS07315	COG1222	aaa ATPase
D3H65_RS07345	COG0358	DNA primase activity
D3H65_RS07355	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D3H65_RS07385	COG3279	Response regulator of the LytR AlgR family
D3H65_RS07395	COG0745	RESPONSE REGULATOR receiver
D3H65_RS07400	COG5002	protein histidine kinase activity
D3H65_RS07410	COG3781	membrane
D3H65_RS07460	COG3385	transposase activity
D3H65_RS07465	COG2204	response regulator
D3H65_RS07480	COG0508	dehydrogenase complex catalyzes the overall conversion of
D3H65_RS07480	COG0022	dehydrogenase e1 component
D3H65_RS07490	COG3279	Response regulator of the LytR AlgR family
D3H65_RS07510	COG0629	single-stranded DNA binding
D3H65_RS07520	COG0183	Belongs to the thiolase family
D3H65_RS07545	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
D3H65_RS07570	COG0012	GTP binding
D3H65_RS07585	COG1629	transport
D3H65_RS07585	COG4206	TonB-dependent receptor
D3H65_RS07605	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D3H65_RS07620	COG0724	RNA recognition motif
D3H65_RS07640	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D3H65_RS07655	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
D3H65_RS07660	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
D3H65_RS07665	COG2706	6-phosphogluconolactonase activity
D3H65_RS07690	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D3H65_RS07720	COG0659	secondary active sulfate transmembrane transporter activity
D3H65_RS07745	COG0156	8-amino-7-oxononanoate synthase activity
D3H65_RS07755	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
D3H65_RS07770	COG0601	transmembrane transport
D3H65_RS07785	COG3275	phosphorelay sensor kinase activity
D3H65_RS07790	COG3279	Response regulator of the LytR AlgR family
D3H65_RS07795	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
D3H65_RS07805	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D3H65_RS07830	COG4206	TonB-dependent receptor
D3H65_RS07830	COG1629	transport
D3H65_RS07870	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
D3H65_RS07900	COG2942	2-epimerase
D3H65_RS07905	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
D3H65_RS07915	COG4124	Belongs to the glycosyl hydrolase 26 family
D3H65_RS07930	COG4206	TonB-dependent receptor
D3H65_RS07930	COG1629	transport
D3H65_RS07935	COG2207	Transcriptional regulator
D3H65_RS08005	COG0577	efflux transmembrane transporter activity
D3H65_RS08005	COG1136	(ABC) transporter
D3H65_RS08035	COG2814	Major facilitator Superfamily
D3H65_RS08050	COG1629	transport
D3H65_RS08050	COG4206	TonB-dependent receptor
D3H65_RS08060	COG1309	transcriptional regulator
D3H65_RS08065	COG0492	ferredoxin-NADP+ reductase activity
D3H65_RS08070	COG1028	Short-chain dehydrogenase reductase Sdr
D3H65_RS08075	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D3H65_RS08080	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D3H65_RS08115	COG4206	TonB-dependent receptor
D3H65_RS08115	COG1629	transport
D3H65_RS08160	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
D3H65_RS08205	COG2197	response regulator
D3H65_RS08215	COG1028	Short-chain dehydrogenase reductase Sdr
D3H65_RS08245	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D3H65_RS08250	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
D3H65_RS08265	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D3H65_RS08280	COG0519	Catalyzes the synthesis of GMP from XMP
D3H65_RS08285	COG3851	Histidine kinase
D3H65_RS08295	COG4251	negative regulation of phosphorylation
D3H65_RS08320	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
D3H65_RS08335	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D3H65_RS08335	COG1199	ATP-dependent helicase activity
D3H65_RS08340	COG0525	valine-tRNA ligase activity
D3H65_RS08350	COG2339	peptidase activity
D3H65_RS08380	COG1216	Glycosyl transferase, family 2
D3H65_RS08420	COG0745	RESPONSE REGULATOR receiver
D3H65_RS08420	COG2972	Histidine kinase
D3H65_RS08430	COG2972	Histidine kinase
D3H65_RS08430	COG0745	RESPONSE REGULATOR receiver
D3H65_RS08435	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
D3H65_RS08465	COG0577	efflux transmembrane transporter activity
D3H65_RS08465	COG1136	(ABC) transporter
D3H65_RS08470	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
D3H65_RS08475	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
D3H65_RS08510	COG1752	Esterase of the alpha-beta hydrolase superfamily
D3H65_RS08525	COG2989	Protein conserved in bacteria
D3H65_RS08530	COG2205	protein histidine kinase activity
D3H65_RS08560	COG3278	Belongs to the heme-copper respiratory oxidase family
D3H65_RS08585	COG0427	acetyl-CoA hydrolase
D3H65_RS08590	COG1105	Belongs to the carbohydrate kinase PfkB family
D3H65_RS08615	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D3H65_RS08620	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
D3H65_RS08635	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D3H65_RS08650	COG0730	response to heat
D3H65_RS08655	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D3H65_RS08655	COG0574	Belongs to the PEP-utilizing enzyme family
D3H65_RS08675	COG0628	permease
D3H65_RS08680	COG0058	SHG alpha-glucan phosphorylase activity
D3H65_RS08695	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
D3H65_RS08710	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D3H65_RS08735	COG1136	(ABC) transporter
D3H65_RS08740	COG0577	efflux transmembrane transporter activity
D3H65_RS08740	COG1136	(ABC) transporter
D3H65_RS08765	COG3279	Response regulator of the LytR AlgR family
D3H65_RS08770	COG3275	phosphorelay sensor kinase activity
D3H65_RS08795	COG3604	Transcriptional regulator
D3H65_RS08820	COG0596	Alpha beta hydrolase
D3H65_RS08840	COG1874	Beta-galactosidase
D3H65_RS08850	COG1082	Xylose isomerase domain protein TIM barrel
D3H65_RS08860	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
D3H65_RS08870	COG0561	phosphatase activity
D3H65_RS08875	COG1629	transport
D3H65_RS08875	COG4206	TonB-dependent receptor
D3H65_RS08880	COG1501	Belongs to the glycosyl hydrolase 31 family
D3H65_RS08900	COG1472	Belongs to the glycosyl hydrolase 3 family
D3H65_RS08915	COG4206	TonB-dependent receptor
D3H65_RS08915	COG1629	transport
D3H65_RS08925	COG1063	alcohol dehydrogenase
D3H65_RS08935	COG3254	rhamnose metabolic process
D3H65_RS08940	COG0738	Major facilitator superfamily
D3H65_RS08960	COG1082	Xylose isomerase domain protein TIM barrel
D3H65_RS08965	COG1501	Belongs to the glycosyl hydrolase 31 family
D3H65_RS08970	COG1609	Transcriptional regulator
D3H65_RS08980	COG4654	Cytochrome c, class I
D3H65_RS08985	COG2382	esterase
D3H65_RS09015	COG2382	esterase
D3H65_RS09020	COG3693	PFAM glycoside hydrolase, family 10
D3H65_RS09025	COG1082	Xylose isomerase domain protein TIM barrel
D3H65_RS09050	COG4206	TonB-dependent receptor
D3H65_RS09050	COG1629	transport
D3H65_RS09075	COG1629	transport
D3H65_RS09075	COG4206	TonB-dependent receptor
D3H65_RS09085	COG3693	PFAM glycoside hydrolase, family 10
D3H65_RS09085	COG2382	esterase
D3H65_RS09100	COG2382	esterase
D3H65_RS09105	COG2382	esterase
D3H65_RS09180	COG1629	transport
D3H65_RS09180	COG4206	TonB-dependent receptor
D3H65_RS09205	COG1082	Xylose isomerase domain protein TIM barrel
D3H65_RS09265	COG1607	acyl-coa hydrolase
D3H65_RS09330	COG1629	transport
D3H65_RS09330	COG4206	TonB-dependent receptor
D3H65_RS09350	COG2814	Major facilitator Superfamily
D3H65_RS09375	COG0726	polysaccharide deacetylase
D3H65_RS09395	COG5002	protein histidine kinase activity
D3H65_RS09400	COG0745	RESPONSE REGULATOR receiver
D3H65_RS09425	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D3H65_RS09470	COG1028	Short-chain dehydrogenase reductase Sdr
D3H65_RS09490	COG3655	Transcriptional regulator
D3H65_RS09535	COG1858	cytochrome C peroxidase
D3H65_RS09605	COG0671	phosphoesterase, PA-phosphatase related
D3H65_RS09615	COG0788	formyltetrahydrofolate deformylase activity
D3H65_RS09625	COG2226	methyltransferase
D3H65_RS09650	COG3275	phosphorelay sensor kinase activity
D3H65_RS09695	COG1733	regulation of RNA biosynthetic process
D3H65_RS09705	COG1609	Transcriptional regulator
D3H65_RS09760	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
D3H65_RS09770	COG2271	Major facilitator Superfamily
D3H65_RS09780	COG5285	phytanoyl-CoA dioxygenase
D3H65_RS09795	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
D3H65_RS09800	COG2264	protein methyltransferase activity
D3H65_RS09805	COG1185	polyribonucleotide nucleotidyltransferase activity
D3H65_RS09810	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
D3H65_RS09815	COG0673	inositol 2-dehydrogenase activity
D3H65_RS09835	COG2884	Cell division ATP-binding protein ftsE
D3H65_RS09855	COG0346	lactoylglutathione lyase activity
D3H65_RS09860	COG0456	acetyltransferase
D3H65_RS09860	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
D3H65_RS09880	COG0456	acetyltransferase
D3H65_RS09895	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
D3H65_RS09935	COG2197	response regulator
D3H65_RS09940	COG4585	Histidine kinase
D3H65_RS09990	COG1131	(ABC) transporter
D3H65_RS10025	COG1629	transport
D3H65_RS10025	COG4206	TonB-dependent receptor
D3H65_RS10040	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
D3H65_RS10045	COG3604	Transcriptional regulator
D3H65_RS10055	COG4774	siderophore transport
D3H65_RS10060	COG0720	synthase
D3H65_RS10070	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
D3H65_RS10140	COG1289	transmembrane transporter activity
D3H65_RS10155	COG1629	transport
D3H65_RS10155	COG4206	TonB-dependent receptor
D3H65_RS10180	COG0477	Major facilitator Superfamily
D3H65_RS10195	COG4206	TonB-dependent receptor
D3H65_RS10195	COG1629	transport
D3H65_RS10215	COG0473	3-isopropylmalate dehydrogenase activity
D3H65_RS10220	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D3H65_RS10225	COG0066	3-isopropylmalate dehydratase activity
D3H65_RS10230	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
D3H65_RS10280	COG0667	Aldo Keto reductase
D3H65_RS10295	COG3119	arylsulfatase activity
D3H65_RS10375	COG1136	(ABC) transporter
D3H65_RS10375	COG0577	efflux transmembrane transporter activity
D3H65_RS10390	COG2808	Putative FMN-binding domain
D3H65_RS10470	COG2311	Membrane
D3H65_RS10490	COG4206	TonB-dependent receptor
D3H65_RS10490	COG1629	transport
D3H65_RS10550	COG0387	Pfam Sodium calcium exchanger
D3H65_RS10555	COG4585	Histidine kinase
D3H65_RS10590	COG0025	NhaP-type Na H and K H
D3H65_RS10605	COG3275	phosphorelay sensor kinase activity
D3H65_RS10610	COG3279	Response regulator of the LytR AlgR family
D3H65_RS10620	COG0640	Transcriptional regulator
D3H65_RS10680	COG1629	transport
D3H65_RS10680	COG4206	TonB-dependent receptor
D3H65_RS10705	COG0489	protein tyrosine kinase activity
D3H65_RS10720	COG0438	transferase activity, transferring glycosyl groups
D3H65_RS10730	COG2171	N-acyltransferase activity
D3H65_RS10740	COG0438	transferase activity, transferring glycosyl groups
D3H65_RS10765	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D3H65_RS10775	COG0463	Glycosyl transferase, family 2
D3H65_RS10800	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
D3H65_RS10820	COG0481	GTPase activity
D3H65_RS10875	COG0697	spore germination
D3H65_RS10880	COG0730	response to heat
D3H65_RS10890	COG0285	dihydrofolate synthase activity
D3H65_RS10895	COG0494	nUDIX hydrolase
D3H65_RS10900	COG0247	lactate metabolic process
D3H65_RS10905	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
D3H65_RS10915	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D3H65_RS10925	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
D3H65_RS10945	COG0366	Alpha amylase catalytic
D3H65_RS10995	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D3H65_RS11000	COG0297	glycogen (starch) synthase activity
D3H65_RS11005	COG0738	Major facilitator superfamily
D3H65_RS11010	COG1940	carbohydrate kinase activity
D3H65_RS11020	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
D3H65_RS11040	COG0424	maF-like protein
D3H65_RS11050	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
D3H65_RS11055	COG0793	Belongs to the peptidase S41A family
D3H65_RS11080	COG1136	(ABC) transporter
D3H65_RS11080	COG0577	efflux transmembrane transporter activity
D3H65_RS11115	COG1914	H( )-stimulated, divalent metal cation uptake system
D3H65_RS11120	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
D3H65_RS11125	COG1984	allophanate hydrolase subunit 2
D3H65_RS11130	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
D3H65_RS11160	COG3279	Response regulator of the LytR AlgR family
D3H65_RS11165	COG3275	phosphorelay sensor kinase activity
D3H65_RS11185	COG1629	transport
D3H65_RS11185	COG4206	TonB-dependent receptor
D3H65_RS11195	COG0673	inositol 2-dehydrogenase activity
D3H65_RS11200	COG0673	inositol 2-dehydrogenase activity
D3H65_RS11205	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D3H65_RS11210	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D3H65_RS11220	COG0604	alcohol dehydrogenase
D3H65_RS11225	COG0633	Ferredoxin
D3H65_RS11230	COG1252	NADH dehydrogenase
D3H65_RS11235	COG1917	Cupin 2, conserved barrel domain protein
D3H65_RS11235	COG4977	sequence-specific DNA binding
D3H65_RS11295	COG1113	amino acid transport
D3H65_RS11305	COG4303	Ethanolamine ammonia lyase large subunit
D3H65_RS11310	COG4302	ethanolamine ammonia-lyase activity
D3H65_RS11375	COG0527	aspartate kinase activity
D3H65_RS11395	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
D3H65_RS11410	COG0860	N-Acetylmuramoyl-L-alanine amidase
D3H65_RS11415	COG0860	N-Acetylmuramoyl-L-alanine amidase
D3H65_RS11450	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
D3H65_RS11460	COG2366	antibiotic biosynthetic process
D3H65_RS11470	COG2192	nodulation
D3H65_RS11510	COG1819	glycosyl
D3H65_RS11515	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D3H65_RS11520	COG1136	(ABC) transporter
D3H65_RS11520	COG0577	efflux transmembrane transporter activity
D3H65_RS11535	COG1349	DNA-binding transcription factor activity
D3H65_RS11540	COG4206	TonB-dependent receptor
D3H65_RS11540	COG1629	transport
D3H65_RS11555	COG1349	DNA-binding transcription factor activity
D3H65_RS11560	COG4206	TonB-dependent receptor
D3H65_RS11560	COG1629	transport
D3H65_RS11575	COG0700	Nucleoside recognition
D3H65_RS11595	COG2382	esterase
D3H65_RS11660	COG1629	transport
D3H65_RS11660	COG4206	TonB-dependent receptor
D3H65_RS11710	COG4206	TonB-dependent receptor
D3H65_RS11710	COG1629	transport
D3H65_RS11725	COG0561	phosphatase activity
D3H65_RS11740	COG2814	Major facilitator Superfamily
D3H65_RS11760	COG3507	Belongs to the glycosyl hydrolase 43 family
D3H65_RS11795	COG1309	transcriptional regulator
D3H65_RS11820	COG0596	Alpha beta hydrolase
D3H65_RS11835	COG2207	Transcriptional regulator
D3H65_RS11850	COG1472	Belongs to the glycosyl hydrolase 3 family
D3H65_RS11890	COG1215	transferase activity, transferring glycosyl groups
D3H65_RS11990	COG3279	Response regulator of the LytR AlgR family
D3H65_RS11995	COG3275	phosphorelay sensor kinase activity
D3H65_RS12010	COG4206	TonB-dependent receptor
D3H65_RS12010	COG1629	transport
D3H65_RS12040	COG0745	RESPONSE REGULATOR receiver
D3H65_RS12055	COG1629	transport
D3H65_RS12055	COG4206	TonB-dependent receptor
D3H65_RS12085	COG1064	alcohol dehydrogenase
D3H65_RS12150	COG1733	regulation of RNA biosynthetic process
D3H65_RS12160	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
D3H65_RS12240	COG3590	peptidase
D3H65_RS12285	COG4948	Mandelate Racemase Muconate Lactonizing
D3H65_RS12290	COG1640	4-alpha-glucanotransferase
D3H65_RS12300	COG3185	4-Hydroxyphenylpyruvate dioxygenase
D3H65_RS12305	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D3H65_RS12310	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
D3H65_RS12315	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D3H65_RS12320	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D3H65_RS12330	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
D3H65_RS12340	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
D3H65_RS12345	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D3H65_RS12355	COG3938	Belongs to the proline racemase family
D3H65_RS12365	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D3H65_RS12370	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D3H65_RS12380	COG0552	protein localization to endoplasmic reticulum
D3H65_RS12390	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D3H65_RS12395	COG0227	Belongs to the bacterial ribosomal protein bL28 family
D3H65_RS12405	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
D3H65_RS12410	COG0248	Ppx GppA phosphatase
D3H65_RS12415	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
D3H65_RS12425	COG1012	belongs to the aldehyde dehydrogenase family
D3H65_RS12430	COG2885	chlorophyll binding
D3H65_RS12435	COG1404	Belongs to the peptidase S8 family
D3H65_RS12460	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D3H65_RS12480	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
D3H65_RS12485	COG2755	lipolytic protein G-D-S-L family
D3H65_RS12485	COG0657	acetylesterase activity
D3H65_RS12520	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D3H65_RS12535	COG4206	TonB-dependent receptor
D3H65_RS12535	COG1629	transport
D3H65_RS12560	COG4232	protein-disulfide reductase activity
D3H65_RS12585	COG0561	phosphatase activity
D3H65_RS12595	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
D3H65_RS12610	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D3H65_RS12615	COG4948	Mandelate Racemase Muconate Lactonizing
D3H65_RS12625	COG2197	response regulator
D3H65_RS12665	COG2721	sulfolactate sulfo-lyase activity
D3H65_RS12715	COG1629	transport
D3H65_RS12715	COG4206	TonB-dependent receptor
D3H65_RS12755	COG1733	regulation of RNA biosynthetic process
D3H65_RS12795	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D3H65_RS12815	COG4206	TonB-dependent receptor
D3H65_RS12815	COG1629	transport
D3H65_RS12830	COG1166	arginine decarboxylase activity
D3H65_RS12835	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
D3H65_RS12840	COG0291	Belongs to the bacterial ribosomal protein bL35 family
D3H65_RS12860	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
D3H65_RS12865	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D3H65_RS12910	COG0488	(ABC) transporter
D3H65_RS12925	COG1752	Esterase of the alpha-beta hydrolase superfamily
D3H65_RS12950	COG1228	amidohydrolase
D3H65_RS12965	COG3387	PFAM Glycoside hydrolase 15-related
D3H65_RS12975	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
D3H65_RS12990	COG2211	Major facilitator Superfamily
D3H65_RS12995	COG0673	inositol 2-dehydrogenase activity
D3H65_RS13000	COG4993	Dehydrogenase
D3H65_RS13015	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D3H65_RS13025	COG0247	lactate metabolic process
D3H65_RS13025	COG2181	nitrate reductase activity
D3H65_RS13030	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
D3H65_RS13080	COG2181	nitrate reductase activity
D3H65_RS13080	COG0247	lactate metabolic process
D3H65_RS13125	COG3852	Histidine kinase
D3H65_RS13130	COG2204	response regulator
D3H65_RS13145	COG1136	(ABC) transporter
D3H65_RS13150	COG0577	efflux transmembrane transporter activity
D3H65_RS13160	COG0577	efflux transmembrane transporter activity
D3H65_RS13160	COG1136	(ABC) transporter
D3H65_RS13165	COG0577	efflux transmembrane transporter activity
D3H65_RS13170	COG0577	efflux transmembrane transporter activity
D3H65_RS13170	COG1136	(ABC) transporter
D3H65_RS13180	COG1136	(ABC) transporter
D3H65_RS13180	COG0577	efflux transmembrane transporter activity
D3H65_RS13195	COG0577	efflux transmembrane transporter activity
D3H65_RS13200	COG1136	(ABC) transporter
D3H65_RS13200	COG0577	efflux transmembrane transporter activity
D3H65_RS13205	COG0577	efflux transmembrane transporter activity
D3H65_RS13205	COG1136	(ABC) transporter
D3H65_RS13225	COG1136	(ABC) transporter
D3H65_RS13225	COG0577	efflux transmembrane transporter activity
D3H65_RS13230	COG0577	efflux transmembrane transporter activity
D3H65_RS13235	COG0577	efflux transmembrane transporter activity
D3H65_RS13235	COG1136	(ABC) transporter
D3H65_RS13240	COG1136	(ABC) transporter
D3H65_RS13240	COG0577	efflux transmembrane transporter activity
D3H65_RS13275	COG1136	(ABC) transporter
D3H65_RS13320	COG1752	Esterase of the alpha-beta hydrolase superfamily
D3H65_RS13330	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D3H65_RS13355	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D3H65_RS13360	COG1295	ribonuclease BN
D3H65_RS13395	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D3H65_RS13420	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
D3H65_RS13440	COG0545	Peptidyl-prolyl cis-trans isomerase
D3H65_RS13480	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D3H65_RS13485	COG1051	belongs to the nudix hydrolase family
D3H65_RS13500	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
D3H65_RS13505	COG0540	Belongs to the ATCase OTCase family
D3H65_RS13510	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
D3H65_RS13535	COG1012	belongs to the aldehyde dehydrogenase family
D3H65_RS13555	COG2205	protein histidine kinase activity
D3H65_RS13600	COG0584	glycerophosphoryl diester phosphodiesterase
D3H65_RS13610	COG4771	TonB-dependent receptor
D3H65_RS13625	COG0333	Belongs to the bacterial ribosomal protein bL32 family
D3H65_RS13630	COG0416	fatty acid biosynthetic process
D3H65_RS13655	COG0745	RESPONSE REGULATOR receiver
D3H65_RS13655	COG2972	Histidine kinase
D3H65_RS13675	COG0531	amino acid
D3H65_RS13700	COG4565	transcriptional regulatory protein
D3H65_RS13720	COG0557	exoribonuclease II activity
D3H65_RS13725	COG1663	tetraacyldisaccharide 4'-kinase activity
D3H65_RS13730	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
D3H65_RS13735	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
D3H65_RS13750	COG0534	Mate efflux family protein
D3H65_RS13755	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
D3H65_RS13755	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D3H65_RS13760	COG0492	ferredoxin-NADP+ reductase activity
D3H65_RS13770	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D3H65_RS13790	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D3H65_RS13795	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
D3H65_RS13800	COG0196	riboflavin kinase activity
D3H65_RS13805	COG1466	dna polymerase III delta subunit
D3H65_RS13825	COG0488	(ABC) transporter
D3H65_RS13840	COG2514	catechol 2,3-dioxygenase activity
D3H65_RS13845	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D3H65_RS13850	COG1053	succinate dehydrogenase
D3H65_RS13860	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
D3H65_RS13865	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
D3H65_RS13885	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D3H65_RS13895	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
D3H65_RS13925	COG1119	ATPase activity
D3H65_RS13935	COG0657	acetylesterase activity
D3H65_RS13935	COG2755	lipolytic protein G-D-S-L family
D3H65_RS13945	COG0667	Aldo Keto reductase
D3H65_RS13960	COG0577	efflux transmembrane transporter activity
D3H65_RS13995	COG2197	response regulator
D3H65_RS14000	COG0823	Involved in the tonB-independent uptake of proteins
D3H65_RS14005	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D3H65_RS14060	COG4335	DNA alkylation repair
D3H65_RS14065	COG1609	Transcriptional regulator
D3H65_RS14080	COG3940	Belongs to the glycosyl hydrolase 43 family
D3H65_RS14105	COG4206	TonB-dependent receptor
D3H65_RS14105	COG1629	transport
D3H65_RS14115	COG0745	RESPONSE REGULATOR receiver
D3H65_RS14125	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D3H65_RS14180	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D3H65_RS14200	COG0328	RNA-DNA hybrid ribonuclease activity
D3H65_RS14215	COG0792	nuclease activity
D3H65_RS14225	COG4974	Belongs to the 'phage' integrase family
D3H65_RS14270	COG3239	Fatty acid desaturase
D3H65_RS14275	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D3H65_RS14285	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D3H65_RS14295	COG3275	phosphorelay sensor kinase activity
D3H65_RS14300	COG3279	Response regulator of the LytR AlgR family
D3H65_RS14310	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D3H65_RS14350	COG0824	Thioesterase
D3H65_RS14365	COG5658	integral membrane protein
D3H65_RS14370	COG0640	Transcriptional regulator
D3H65_RS14380	COG2169	Transcriptional regulator
D3H65_RS14385	COG4941	Belongs to the sigma-70 factor family
D3H65_RS14390	COG4206	TonB-dependent receptor
D3H65_RS14390	COG1629	transport
D3H65_RS14400	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D3H65_RS14425	COG0508	dehydrogenase complex catalyzes the overall conversion of
D3H65_RS14450	COG0463	Glycosyl transferase, family 2
D3H65_RS14455	COG2176	DNA-directed DNA polymerase activity
D3H65_RS14460	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D3H65_RS14480	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D3H65_RS14500	COG0321	lipoyl(octanoyl) transferase activity
D3H65_RS14505	COG0564	pseudouridine synthase activity
D3H65_RS14515	COG0242	peptide deformylase activity
D3H65_RS14520	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
D3H65_RS14525	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
D3H65_RS14530	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D3H65_RS14535	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D3H65_RS14540	COG0539	negative regulation of cytoplasmic translation
D3H65_RS14550	COG2081	HI0933 family
D3H65_RS14565	COG0200	Binds to the 23S rRNA
D3H65_RS14570	COG1841	ribosomal large subunit assembly
D3H65_RS14575	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
D3H65_RS14585	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
D3H65_RS14590	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
D3H65_RS14595	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D3H65_RS14600	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
D3H65_RS14605	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
D3H65_RS14610	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
D3H65_RS14615	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
D3H65_RS14620	COG0255	Belongs to the universal ribosomal protein uL29 family
D3H65_RS14625	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
D3H65_RS14630	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
D3H65_RS14640	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
D3H65_RS14645	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
D3H65_RS14650	COG0089	rRNA binding
D3H65_RS14655	COG0088	Forms part of the polypeptide exit tunnel
D3H65_RS14660	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
D3H65_RS14665	COG0051	transcription antitermination factor activity, RNA binding
D3H65_RS14680	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D3H65_RS14695	COG0049	tRNA binding
D3H65_RS14700	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
D3H65_RS14705	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D3H65_RS14720	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
D3H65_RS14740	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D3H65_RS14765	COG0706	membrane insertase activity
D3H65_RS14770	COG0504	CTP synthase activity
D3H65_RS14785	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D3H65_RS14790	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D3H65_RS14850	COG1696	Membrane protein involved in D-alanine export
D3H65_RS14855	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
D3H65_RS14860	COG0542	response to heat
D3H65_RS14870	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
D3H65_RS14895	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
D3H65_RS14910	COG3279	Response regulator of the LytR AlgR family
D3H65_RS14955	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D3H65_RS14955	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D3H65_RS15015	COG1629	transport
D3H65_RS15015	COG4206	TonB-dependent receptor
D3H65_RS15025	COG1914	H( )-stimulated, divalent metal cation uptake system
D3H65_RS15060	COG0545	Peptidyl-prolyl cis-trans isomerase
D3H65_RS15085	COG2234	aminopeptidase activity
D3H65_RS15090	COG0488	(ABC) transporter
D3H65_RS15095	COG4585	Histidine kinase
D3H65_RS15115	COG1181	Belongs to the D-alanine--D-alanine ligase family
D3H65_RS15130	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
D3H65_RS15140	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D3H65_RS15145	COG0366	Alpha amylase catalytic
D3H65_RS15150	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
D3H65_RS15155	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
D3H65_RS15160	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D3H65_RS15170	COG2239	Acts as a magnesium transporter
D3H65_RS15195	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D3H65_RS15195	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
D3H65_RS15200	COG0542	response to heat
D3H65_RS15210	COG1070	Carbohydrate kinase
D3H65_RS15220	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
D3H65_RS15250	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D3H65_RS15270	COG0616	signal peptide processing
D3H65_RS15280	COG1428	Deoxynucleoside kinase
D3H65_RS15290	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D3H65_RS15290	COG4651	solute:proton antiporter activity
D3H65_RS15310	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D3H65_RS15310	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D3H65_RS15355	COG0484	heat shock protein binding
D3H65_RS15395	COG1595	DNA-templated transcription, initiation
D3H65_RS15400	COG1228	amidohydrolase
D3H65_RS15405	COG3409	Peptidoglycan-binding domain 1 protein
D3H65_RS15405	COG0793	Belongs to the peptidase S41A family
D3H65_RS15410	COG2207	Transcriptional regulator
D3H65_RS15420	COG4773	Receptor
D3H65_RS15470	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D3H65_RS15475	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D3H65_RS15490	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
D3H65_RS15515	COG2010	Cytochrome c
D3H65_RS15515	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D3H65_RS15520	COG2080	2 iron, 2 sulfur cluster binding
D3H65_RS15555	COG0673	inositol 2-dehydrogenase activity
D3H65_RS15605	COG3189	MarR family transcriptional regulator
D3H65_RS15650	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D3H65_RS15665	COG1858	cytochrome C peroxidase
D3H65_RS15675	COG3015	lipoprotein NlpE involved in copper resistance
D3H65_RS15680	COG0708	Exodeoxyribonuclease III
D3H65_RS15690	COG1733	regulation of RNA biosynthetic process
D3H65_RS15695	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
D3H65_RS15700	COG1917	Cupin 2, conserved barrel domain protein
D3H65_RS15700	COG4977	sequence-specific DNA binding
D3H65_RS15710	COG0596	Alpha beta hydrolase
D3H65_RS15720	COG4941	Belongs to the sigma-70 factor family
D3H65_RS15770	COG0745	RESPONSE REGULATOR receiver
D3H65_RS15775	COG5002	protein histidine kinase activity
D3H65_RS15785	COG2226	methyltransferase
D3H65_RS15815	COG4977	sequence-specific DNA binding
D3H65_RS15815	COG1917	Cupin 2, conserved barrel domain protein
D3H65_RS15830	COG2814	Major facilitator Superfamily
D3H65_RS15880	COG3250	beta-galactosidase activity
D3H65_RS15895	COG4206	TonB-dependent receptor
D3H65_RS15895	COG1629	transport
D3H65_RS15905	COG2610	gluconate transmembrane transporter activity
D3H65_RS15915	COG0129	dihydroxy-acid dehydratase activity
D3H65_RS15925	COG1629	transport
D3H65_RS15925	COG4206	TonB-dependent receptor
D3H65_RS15930	COG0662	Cupin 2, conserved barrel domain protein
D3H65_RS15930	COG2207	Transcriptional regulator
D3H65_RS15935	COG1070	Carbohydrate kinase
D3H65_RS15940	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D3H65_RS15945	COG4948	Mandelate Racemase Muconate Lactonizing
D3H65_RS15960	COG4948	Mandelate Racemase Muconate Lactonizing
D3H65_RS16040	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
D3H65_RS16065	COG0825	malonyl-CoA metabolic process
D3H65_RS16070	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D3H65_RS16075	COG1234	tRNA 3'-trailer cleavage
D3H65_RS16080	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
D3H65_RS16080	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
D3H65_RS16085	COG0531	amino acid
D3H65_RS16095	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
D3H65_RS16100	COG0085	RNA polymerase activity
D3H65_RS16105	COG1609	Transcriptional regulator
D3H65_RS16110	COG3537	Alpha-1,2-mannosidase
D3H65_RS16120	COG3537	Alpha-1,2-mannosidase
D3H65_RS16130	COG4206	TonB-dependent receptor
D3H65_RS16130	COG1629	transport
D3H65_RS16145	COG1629	transport
D3H65_RS16145	COG4206	TonB-dependent receptor
D3H65_RS16150	COG0222	ribosome binding
D3H65_RS16155	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D3H65_RS16160	COG0081	regulation of translation
D3H65_RS16165	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
D3H65_RS16220	COG4974	Belongs to the 'phage' integrase family
D3H65_RS16225	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D3H65_RS16230	COG0307	riboflavin synthase, alpha
D3H65_RS16255	COG2192	nodulation
D3H65_RS16270	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D3H65_RS16300	COG4948	Mandelate Racemase Muconate Lactonizing
D3H65_RS16345	COG1595	DNA-templated transcription, initiation
D3H65_RS16370	COG0438	transferase activity, transferring glycosyl groups
D3H65_RS16400	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
D3H65_RS16410	COG1519	Transferase
D3H65_RS16420	COG1435	thymidine kinase activity
D3H65_RS16440	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D3H65_RS16510	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
D3H65_RS16525	COG2755	lipolytic protein G-D-S-L family
D3H65_RS16525	COG0657	acetylesterase activity
D3H65_RS16535	COG0527	aspartate kinase activity
D3H65_RS16550	COG0859	PFAM glycosyl transferase family 9
D3H65_RS16555	COG2814	Major facilitator Superfamily
D3H65_RS16560	COG0586	Pfam SNARE associated Golgi protein
D3H65_RS16565	COG1301	dicarboxylic acid transport
D3H65_RS16580	COG0577	efflux transmembrane transporter activity
D3H65_RS16580	COG1136	(ABC) transporter
D3H65_RS16595	COG2860	membrane
D3H65_RS16685	COG4895	conserved protein (DUF2196)
D3H65_RS16695	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
D3H65_RS16700	COG1538	Outer membrane efflux protein
D3H65_RS16710	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D3H65_RS16725	COG4206	TonB-dependent receptor
D3H65_RS16725	COG1629	transport
D3H65_RS16760	COG1629	transport
D3H65_RS16760	COG4206	TonB-dependent receptor
D3H65_RS16795	COG0697	spore germination
D3H65_RS16805	COG3275	phosphorelay sensor kinase activity
D3H65_RS16810	COG3279	Response regulator of the LytR AlgR family
D3H65_RS16830	COG1086	Polysaccharide biosynthesis protein
D3H65_RS16835	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D3H65_RS16850	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
D3H65_RS16875	COG0438	transferase activity, transferring glycosyl groups
D3H65_RS16885	COG0438	transferase activity, transferring glycosyl groups
D3H65_RS16900	COG1215	transferase activity, transferring glycosyl groups
D3H65_RS16930	COG1132	(ABC) transporter
D3H65_RS16940	COG0489	protein tyrosine kinase activity
D3H65_RS16940	COG3206	protein involved in exopolysaccharide biosynthesis
D3H65_RS16970	COG2169	Transcriptional regulator
D3H65_RS16975	COG0363	glucosamine-6-phosphate deaminase activity
D3H65_RS17030	COG0561	phosphatase activity
D3H65_RS17080	COG3250	beta-galactosidase activity
D3H65_RS17125	COG4206	TonB-dependent receptor
D3H65_RS17125	COG1629	transport
D3H65_RS17140	COG0726	polysaccharide deacetylase
D3H65_RS17180	COG2972	Histidine kinase
D3H65_RS17185	COG3279	Response regulator of the LytR AlgR family
D3H65_RS17195	COG2205	protein histidine kinase activity
D3H65_RS17200	COG5002	protein histidine kinase activity
D3H65_RS17215	COG4251	negative regulation of phosphorylation
D3H65_RS17220	COG2201	protein-glutamate methylesterase activity
D3H65_RS17225	COG0577	efflux transmembrane transporter activity
D3H65_RS17290	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D3H65_RS17330	COG3604	Transcriptional regulator
D3H65_RS17380	COG0673	inositol 2-dehydrogenase activity
D3H65_RS17390	COG2076	Multidrug Resistance protein
D3H65_RS17395	COG2271	Major facilitator Superfamily
D3H65_RS17400	COG0800	Aldolase
D3H65_RS17410	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
D3H65_RS17415	COG1028	Short-chain dehydrogenase reductase Sdr
D3H65_RS17420	COG1904	glucuronate isomerase
D3H65_RS17425	COG2721	sulfolactate sulfo-lyase activity
D3H65_RS17430	COG0246	Mannitol dehydrogenase
D3H65_RS17440	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
D3H65_RS17490	COG2755	lipolytic protein G-D-S-L family
D3H65_RS17510	COG4206	TonB-dependent receptor
D3H65_RS17510	COG1629	transport
D3H65_RS17525	COG1028	Short-chain dehydrogenase reductase Sdr
D3H65_RS17550	COG0561	phosphatase activity
D3H65_RS17555	COG4206	TonB-dependent receptor
D3H65_RS17555	COG1629	transport
D3H65_RS17560	COG1501	Belongs to the glycosyl hydrolase 31 family
D3H65_RS17575	COG1132	(ABC) transporter
D3H65_RS17625	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
D3H65_RS17635	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
D3H65_RS17650	COG4977	sequence-specific DNA binding
D3H65_RS17670	COG0673	inositol 2-dehydrogenase activity
D3H65_RS17690	COG1363	Peptidase, m42
D3H65_RS17715	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
D3H65_RS17720	COG2197	response regulator
D3H65_RS17730	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D3H65_RS17755	COG3279	Response regulator of the LytR AlgR family
D3H65_RS17760	COG4999	Histidine kinase
D3H65_RS17760	COG2205	protein histidine kinase activity
D3H65_RS17760	COG3437	response regulator, receiver
D3H65_RS17760	COG3850	Histidine kinase
D3H65_RS17765	COG1408	metallophosphoesterase
D3H65_RS17775	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
D3H65_RS17780	COG1192	Involved in chromosome partitioning
D3H65_RS17785	COG1475	DNA binding
D3H65_RS17795	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
D3H65_RS17805	COG1959	2 iron, 2 sulfur cluster binding
D3H65_RS17815	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
D3H65_RS17850	COG0791	NLP P60 protein
D3H65_RS17865	COG0590	tRNA wobble adenosine to inosine editing
D3H65_RS17885	COG0720	synthase
D3H65_RS17920	COG3781	membrane
D3H65_RS17930	COG3795	YCII-related domain
D3H65_RS17955	COG0629	single-stranded DNA binding
D3H65_RS17960	COG0482	sulfurtransferase activity
D3H65_RS17980	COG4585	Histidine kinase
D3H65_RS17985	COG2197	response regulator
D3H65_RS17995	COG0508	dehydrogenase complex catalyzes the overall conversion of
D3H65_RS18005	COG0268	Binds directly to 16S ribosomal RNA
D3H65_RS18050	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D3H65_RS18055	COG1595	DNA-templated transcription, initiation
D3H65_RS18060	COG2373	Large extracellular alpha-helical protein
D3H65_RS18065	COG4804	nuclease activity
D3H65_RS18070	COG4953	penicillin-binding protein 1C
D3H65_RS18080	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D3H65_RS18080	COG0519	Catalyzes the synthesis of GMP from XMP
D3H65_RS18095	COG1793	dna ligase
D3H65_RS18100	COG1858	cytochrome C peroxidase
D3H65_RS18120	COG1858	cytochrome C peroxidase
D3H65_RS18130	COG0123	including yeast histone deacetylase and acetoin utilization protein
D3H65_RS18145	COG0653	protein targeting
D3H65_RS18155	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D3H65_RS18200	COG1228	amidohydrolase
D3H65_RS18205	COG0402	S-adenosylhomocysteine deaminase activity
D3H65_RS18210	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
D3H65_RS18220	COG1473	amidohydrolase
D3H65_RS18260	COG1725	Transcriptional regulator
D3H65_RS18270	COG1131	(ABC) transporter
D3H65_RS18275	COG0281	malic enzyme
D3H65_RS18275	COG0280	phosphate acetyltransferase
D3H65_RS18280	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D3H65_RS18285	COG1127	ABC transporter
D3H65_RS18290	COG0165	Argininosuccinate lyase
D3H65_RS18290	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
D3H65_RS18295	COG1733	regulation of RNA biosynthetic process
D3H65_RS18335	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
D3H65_RS18340	COG2197	response regulator
D3H65_RS18355	COG4585	Histidine kinase
D3H65_RS18360	COG2197	response regulator
D3H65_RS18375	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
D3H65_RS18415	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
D3H65_RS18415	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
D3H65_RS18420	COG0326	Molecular chaperone. Has ATPase activity
D3H65_RS18435	COG0360	Binds together with S18 to 16S ribosomal RNA
D3H65_RS18440	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
D3H65_RS18445	COG0359	binds to the 23S rRNA
D3H65_RS18450	COG2989	Protein conserved in bacteria
D3H65_RS18455	COG0724	RNA recognition motif
D3H65_RS18460	COG0463	Glycosyl transferase, family 2
D3H65_RS18470	COG1597	lipid kinase activity
D3H65_RS18490	COG0513	Belongs to the DEAD box helicase family
D3H65_RS18495	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
D3H65_RS18510	COG0673	inositol 2-dehydrogenase activity
D3H65_RS18515	COG1477	protein flavinylation
D3H65_RS18525	COG3279	Response regulator of the LytR AlgR family
D3H65_RS18530	COG3275	phosphorelay sensor kinase activity
D3H65_RS18585	COG0101	tRNA pseudouridine synthase activity
D3H65_RS18615	COG1704	LemA family
D3H65_RS18620	COG2133	pyrroloquinoline quinone binding
D3H65_RS18625	COG3851	Histidine kinase
D3H65_RS18630	COG0126	phosphoglycerate kinase activity
D3H65_RS18685	COG1132	(ABC) transporter
D3H65_RS18730	COG2207	Transcriptional regulator
D3H65_RS18775	COG1629	transport
D3H65_RS18775	COG4206	TonB-dependent receptor
D3H65_RS18780	COG2205	protein histidine kinase activity
D3H65_RS18780	COG4999	Histidine kinase
D3H65_RS18780	COG3850	Histidine kinase
D3H65_RS18780	COG3437	response regulator, receiver
D3H65_RS18790	COG3279	Response regulator of the LytR AlgR family
D3H65_RS18800	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
D3H65_RS18820	COG0019	diaminopimelate decarboxylase activity
D3H65_RS18830	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
D3H65_RS18840	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
D3H65_RS18855	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D3H65_RS18880	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D3H65_RS18885	COG1396	sequence-specific DNA binding
D3H65_RS18910	COG3119	arylsulfatase activity
D3H65_RS18920	COG3250	beta-galactosidase activity
D3H65_RS18925	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
D3H65_RS18930	COG2755	lipolytic protein G-D-S-L family
D3H65_RS18935	COG3401	FG-GAP repeat protein
D3H65_RS18940	COG3401	FG-GAP repeat protein
D3H65_RS18985	COG3250	beta-galactosidase activity
D3H65_RS19000	COG2755	lipolytic protein G-D-S-L family
D3H65_RS19005	COG0561	phosphatase activity
D3H65_RS19025	COG4206	TonB-dependent receptor
D3H65_RS19025	COG1629	transport
D3H65_RS19035	COG4206	TonB-dependent receptor
D3H65_RS19035	COG1629	transport
D3H65_RS19070	COG3275	phosphorelay sensor kinase activity
D3H65_RS19075	COG3279	Response regulator of the LytR AlgR family
D3H65_RS19090	COG4952	isomerase
D3H65_RS19095	COG3254	rhamnose metabolic process
D3H65_RS19100	COG1028	Short-chain dehydrogenase reductase Sdr
D3H65_RS19100	COG3347	Dehydrogenase
D3H65_RS19120	COG4206	TonB-dependent receptor
D3H65_RS19120	COG1629	transport
D3H65_RS19125	COG1940	carbohydrate kinase activity
D3H65_RS19205	COG2271	Major facilitator Superfamily
D3H65_RS19230	COG2186	Transcriptional regulator
D3H65_RS19260	COG1082	Xylose isomerase domain protein TIM barrel
D3H65_RS19270	COG0561	phosphatase activity
D3H65_RS19270	COG0561	phosphatase activity
D3H65_RS19275	COG1629	transport
D3H65_RS19275	COG4206	TonB-dependent receptor
D3H65_RS19330	COG0612	Peptidase, M16
D3H65_RS19350	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
D3H65_RS19375	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D3H65_RS19390	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
D3H65_RS19415	COG0811	peptide transport
D3H65_RS19430	COG1007	ATP synthesis coupled electron transport
D3H65_RS19440	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D3H65_RS19445	COG0713	ATP synthesis coupled electron transport
D3H65_RS19455	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D3H65_RS19460	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
D3H65_RS19465	COG1034	ATP synthesis coupled electron transport
D3H65_RS19475	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
D3H65_RS19480	COG0649	NAD binding
D3H65_RS19485	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D3H65_RS19490	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D3H65_RS19495	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D3H65_RS19520	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D3H65_RS19535	COG1136	(ABC) transporter
D3H65_RS19535	COG0577	efflux transmembrane transporter activity
D3H65_RS19560	COG0820	rRNA (adenine-C2-)-methyltransferase activity
D3H65_RS19565	COG1187	pseudouridine synthase activity
D3H65_RS19570	COG0564	pseudouridine synthase activity
D3H65_RS19575	COG1228	amidohydrolase
D3H65_RS19580	COG0450	alkyl hydroperoxide reductase
D3H65_RS19585	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D3H65_RS19615	COG3279	Response regulator of the LytR AlgR family
D3H65_RS19620	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
D3H65_RS19625	COG0228	four-way junction DNA binding
D3H65_RS19630	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D3H65_RS19635	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D3H65_RS19690	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
D3H65_RS19695	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D3H65_RS19700	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
D3H65_RS19710	COG0336	Belongs to the RNA methyltransferase TrmD family
D3H65_RS19715	COG1501	Belongs to the glycosyl hydrolase 31 family
D3H65_RS19725	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
D3H65_RS19745	COG3275	phosphorelay sensor kinase activity
D3H65_RS19750	COG3279	Response regulator of the LytR AlgR family
D3H65_RS19825	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D3H65_RS19835	COG2094	Belongs to the DNA glycosylase MPG family
D3H65_RS19860	COG0438	transferase activity, transferring glycosyl groups
D3H65_RS19875	COG0756	dUTP diphosphatase activity
D3H65_RS19880	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
D3H65_RS19895	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D3H65_RS19900	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D3H65_RS19920	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D3H65_RS19930	COG0730	response to heat
D3H65_RS19940	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
D3H65_RS19945	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D3H65_RS19945	COG1648	precorrin-2 dehydrogenase activity
D3H65_RS19955	COG0175	sulfate reduction
D3H65_RS19960	COG0175	sulfate reduction
D3H65_RS19965	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D3H65_RS20000	COG2877	3-deoxy-8-phosphooctulonate synthase activity
D3H65_RS20015	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D3H65_RS20025	COG1254	Belongs to the acylphosphatase family
D3H65_RS20045	COG0538	isocitrate dehydrogenase activity
D3H65_RS20090	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
D3H65_RS20095	COG1160	GTP binding
D3H65_RS20115	COG0439	Biotin carboxylase
D3H65_RS20120	COG0511	ligase activity, forming carbon-carbon bonds
D3H65_RS20125	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D3H65_RS20160	COG0024	Methionine aminopeptidase
D3H65_RS20195	COG0564	pseudouridine synthase activity
D3H65_RS20205	COG1136	(ABC) transporter
D3H65_RS20205	COG0577	efflux transmembrane transporter activity
D3H65_RS20210	COG0459	protein refolding
D3H65_RS20215	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
D3H65_RS20255	COG1309	transcriptional regulator
D3H65_RS20260	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
D3H65_RS20270	COG1233	COG1233 Phytoene dehydrogenase and related
D3H65_RS20275	COG3279	Response regulator of the LytR AlgR family
D3H65_RS20280	COG3275	phosphorelay sensor kinase activity
D3H65_RS20290	COG0302	gtp cyclohydrolase
D3H65_RS20340	COG1028	Short-chain dehydrogenase reductase Sdr
D3H65_RS20420	COG0673	inositol 2-dehydrogenase activity
D3H65_RS20430	COG3622	Belongs to the hyi family
D3H65_RS20440	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
D3H65_RS20445	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D3H65_RS20450	COG2153	protein acetylation
D3H65_RS20455	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D3H65_RS20460	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D3H65_RS20465	COG0571	ribonuclease III activity
D3H65_RS20495	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D3H65_RS20560	COG0793	Belongs to the peptidase S41A family
D3H65_RS20560	COG4946	Tricorn protease homolog
D3H65_RS20565	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
D3H65_RS20570	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
D3H65_RS20575	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D3H65_RS20585	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D3H65_RS20600	COG1162	GTPase activity
D3H65_RS20605	COG2304	oxidoreductase activity
D3H65_RS20620	COG0714	Associated with various cellular activities
D3H65_RS20630	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D3H65_RS20630	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
D3H65_RS20665	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
D3H65_RS20675	COG0300	oxidoreductase activity
D3H65_RS20705	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
D3H65_RS20710	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D3H65_RS20720	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D3H65_RS20725	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D3H65_RS20730	COG0165	Argininosuccinate lyase
D3H65_RS20745	COG0668	transmembrane transport
D3H65_RS20765	COG1556	Lactate utilization protein
D3H65_RS20770	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D3H65_RS20780	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
D3H65_RS20780	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
D3H65_RS20820	COG2197	response regulator
D3H65_RS20825	COG4585	Histidine kinase
D3H65_RS20830	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D3H65_RS20840	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D3H65_RS20855	COG4585	Histidine kinase
D3H65_RS20870	COG2333	competence protein COMEC
D3H65_RS20870	COG0658	competence protein
D3H65_RS20875	COG0138	bifunctional purine biosynthesis protein purh
D3H65_RS20880	COG0697	spore germination
D3H65_RS20915	COG0629	single-stranded DNA binding
D3H65_RS20920	COG1194	a g-specific adenine glycosylase
D3H65_RS20925	COG0776	regulation of translation
D3H65_RS20935	COG1530	ribonuclease E activity
D3H65_RS20950	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
D3H65_RS20955	COG1040	competence protein
D3H65_RS20965	COG0386	Belongs to the glutathione peroxidase family
D3H65_RS20975	COG1774	PSP1 C-terminal conserved region
D3H65_RS20985	COG3291	Pkd domain containing protein
D3H65_RS20995	COG0492	ferredoxin-NADP+ reductase activity
D3H65_RS21000	COG2972	Histidine kinase
D3H65_RS21005	COG3279	Response regulator of the LytR AlgR family
D3H65_RS21060	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D3H65_RS21060	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D3H65_RS21065	COG0730	response to heat
D3H65_RS21075	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D3H65_RS21080	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D3H65_RS21105	COG0596	Alpha beta hydrolase
D3H65_RS21140	COG1629	transport
D3H65_RS21140	COG4206	TonB-dependent receptor
D3H65_RS21150	COG1028	Short-chain dehydrogenase reductase Sdr
D3H65_RS21160	COG1522	sequence-specific DNA binding
D3H65_RS21165	COG1104	cysteine desulfurase activity
D3H65_RS21175	COG1285	pathogenesis
D3H65_RS21185	COG0726	polysaccharide deacetylase
D3H65_RS21205	COG2207	Transcriptional regulator
D3H65_RS21265	COG3275	phosphorelay sensor kinase activity
D3H65_RS21270	COG3275	phosphorelay sensor kinase activity
D3H65_RS21275	COG3279	Response regulator of the LytR AlgR family
D3H65_RS21325	COG4999	Histidine kinase
D3H65_RS21325	COG3437	response regulator, receiver
D3H65_RS21325	COG2205	protein histidine kinase activity
D3H65_RS21325	COG3850	Histidine kinase
D3H65_RS21330	COG2204	response regulator
D3H65_RS21345	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
D3H65_RS21375	COG3279	Response regulator of the LytR AlgR family
D3H65_RS21380	COG1611	Belongs to the LOG family
D3H65_RS21385	COG0708	Exodeoxyribonuclease III
D3H65_RS21405	COG0259	pyridoxamine-phosphate oxidase activity
D3H65_RS21415	COG0528	UMP kinase activity
D3H65_RS21420	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
D3H65_RS21425	COG0052	Belongs to the universal ribosomal protein uS2 family
D3H65_RS21430	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
D3H65_RS21435	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
D3H65_RS21475	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
D3H65_RS21490	COG1309	transcriptional regulator
D3H65_RS21500	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D3H65_RS21525	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
D3H65_RS21530	COG1250	3-hydroxyacyl-CoA dehydrogenase
D3H65_RS21535	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D3H65_RS21545	COG3275	phosphorelay sensor kinase activity
D3H65_RS21550	COG3279	Response regulator of the LytR AlgR family
D3H65_RS21555	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D3H65_RS21560	COG1187	pseudouridine synthase activity
D3H65_RS21580	COG0745	RESPONSE REGULATOR receiver
D3H65_RS21590	COG1028	Short-chain dehydrogenase reductase Sdr
D3H65_RS21595	COG1011	Hydrolase
D3H65_RS21600	COG0688	phosphatidylethanolamine metabolic process
D3H65_RS21605	COG0575	Belongs to the CDS family
D3H65_RS21615	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D3H65_RS21620	COG2234	aminopeptidase activity
D3H65_RS21630	COG0386	Belongs to the glutathione peroxidase family
D3H65_RS21635	COG1012	belongs to the aldehyde dehydrogenase family
D3H65_RS21640	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D3H65_RS21655	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D3H65_RS21660	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D3H65_RS21680	COG5297	Belongs to the glycosyl hydrolase family 6
D3H65_RS21680	COG3250	beta-galactosidase activity
D3H65_RS21725	COG1280	lysine exporter protein (LysE YggA)
D3H65_RS21730	COG0626	cystathionine gamma-synthase activity
D3H65_RS21740	COG0367	asparagine synthase
D3H65_RS21775	COG0698	ribose 5-phosphate isomerase
D3H65_RS21780	COG0805	protein transport
D3H65_RS21785	COG4535	Mg2 and Co2 transporter CorC
D3H65_RS21790	COG0194	GDP metabolic process
D3H65_RS21795	COG3279	Response regulator of the LytR AlgR family
D3H65_RS21800	COG3275	phosphorelay sensor kinase activity
D3H65_RS21835	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
D3H65_RS21890	COG1309	transcriptional regulator
D3H65_RS21900	COG0477	Major facilitator Superfamily
D3H65_RS21910	COG0300	oxidoreductase activity
D3H65_RS21915	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
D3H65_RS21925	COG3428	Bacterial PH domain
D3H65_RS21930	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D3H65_RS21960	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
D3H65_RS21970	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
D3H65_RS21975	COG0594	ribonuclease P activity
D3H65_RS21980	COG0230	Belongs to the bacterial ribosomal protein bL34 family
D3H65_RS21990	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
D3H65_RS22010	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D3H65_RS22020	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
D3H65_RS22045	COG1610	YqeY-like protein
D3H65_RS22060	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D3H65_RS22085	COG3279	Response regulator of the LytR AlgR family
D3H65_RS22090	COG2972	Histidine kinase
D3H65_RS22090	COG0745	RESPONSE REGULATOR receiver
D3H65_RS22095	COG3275	phosphorelay sensor kinase activity
D3H65_RS22115	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D3H65_RS22135	COG1597	lipid kinase activity
D3H65_RS22145	COG1612	heme a metabolic process
D3H65_RS22170	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
D3H65_RS22195	COG1013	pyruvate-flavodoxin oxidoreductase activity
D3H65_RS22205	COG0823	Involved in the tonB-independent uptake of proteins
D3H65_RS22205	COG1506	peptidase
D3H65_RS22205	COG4946	Tricorn protease homolog
D3H65_RS22220	COG0724	RNA recognition motif
D3H65_RS22230	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
D3H65_RS22235	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
D3H65_RS22240	COG0363	glucosamine-6-phosphate deaminase activity
D3H65_RS22245	COG4316	Uncharacterized protein conserved in bacteria (DUF2251)
D3H65_RS22255	COG0860	N-Acetylmuramoyl-L-alanine amidase
D3H65_RS22260	COG1960	acyl-CoA dehydrogenase activity
D3H65_RS22280	COG1215	transferase activity, transferring glycosyl groups
D3H65_RS22295	COG1522	sequence-specific DNA binding
D3H65_RS22305	COG0220	tRNA (guanine-N7-)-methyltransferase activity
D3H65_RS22315	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D3H65_RS22325	COG2322	membrane
D3H65_RS22350	COG0109	protoheme IX farnesyltransferase activity
D3H65_RS22355	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D3H65_RS22385	COG0437	4 iron, 4 sulfur cluster binding
D3H65_RS22410	COG3548	integral membrane protein
D3H65_RS22415	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D3H65_RS22430	COG3237	CsbD-like
D3H65_RS22455	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
D3H65_RS22460	COG4206	TonB-dependent receptor
D3H65_RS22460	COG1629	transport
D3H65_RS22495	COG0022	dehydrogenase e1 component
D3H65_RS22515	COG1950	PFAM Membrane protein of
D3H65_RS22525	COG0612	Peptidase, M16
D3H65_RS22535	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
D3H65_RS22540	COG5002	protein histidine kinase activity
D3H65_RS22540	COG2205	protein histidine kinase activity
D3H65_RS22540	COG0784	Response regulator, receiver
D3H65_RS22580	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D3H65_RS22595	COG2154	pterin-4-alpha-carbinolamine dehydratase
D3H65_RS22615	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
D3H65_RS22620	COG2045	Belongs to the ComB family
D3H65_RS22630	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D3H65_RS22675	COG0017	Asparaginyl-tRNA synthetase
D3H65_RS22680	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D3H65_RS22720	COG0436	Aminotransferase
D3H65_RS22725	COG0251	oxidation-reduction process
D3H65_RS22735	COG0662	Cupin 2, conserved barrel domain protein
D3H65_RS22735	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
D3H65_RS22745	COG0514	ATP-dependent DNA helicase (RecQ)
D3H65_RS22760	COG3876	Protein conserved in bacteria
D3H65_RS22765	COG0724	RNA recognition motif
D3H65_RS22775	COG0006	proline dipeptidase activity
D3H65_RS22790	COG0577	efflux transmembrane transporter activity
D3H65_RS22825	COG3275	phosphorelay sensor kinase activity
D3H65_RS22855	COG1999	signal sequence binding
D3H65_RS22865	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
D3H65_RS22920	COG0592	DNA-directed DNA polymerase activity
D3H65_RS22950	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
D3H65_RS22955	COG1940	carbohydrate kinase activity
D3H65_RS22960	COG1454	alcohol dehydrogenase
D3H65_RS22970	COG0598	Magnesium transport protein CorA
D3H65_RS22980	COG1294	oxidase, subunit
D3H65_RS22985	COG1271	oxidase subunit
D3H65_RS23000	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
D3H65_RS23005	COG1956	GAF domain-containing protein
D3H65_RS23010	COG0445	tRNA wobble uridine modification
D3H65_RS23015	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
D3H65_RS23025	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
D3H65_RS23050	COG4585	Histidine kinase
D3H65_RS23060	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D3H65_RS23065	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
D3H65_RS23080	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
D3H65_RS23095	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D3H65_RS23125	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
D3H65_RS23175	COG3275	phosphorelay sensor kinase activity
D3H65_RS23200	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D3H65_RS23210	COG1132	(ABC) transporter
D3H65_RS23215	COG0513	Belongs to the DEAD box helicase family
D3H65_RS23245	COG3264	Mechanosensitive ion channel
D3H65_RS23245	COG1196	nuclear chromosome segregation
D3H65_RS23255	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D3H65_RS23255	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D3H65_RS23260	COG0556	nucleotide-excision repair
D3H65_RS23265	COG1803	Methylglyoxal synthase
D3H65_RS23275	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
D3H65_RS23330	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D3H65_RS23335	COG0210	DNA helicase
D3H65_RS23350	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D3H65_RS23370	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D3H65_RS23400	COG1309	transcriptional regulator
D3H65_RS23405	COG0824	Thioesterase
D3H65_RS23410	COG3851	Histidine kinase
D3H65_RS23415	COG0697	spore germination
D3H65_RS23440	COG4191	Histidine kinase
D3H65_RS23445	COG2204	response regulator
D3H65_RS23450	COG1136	(ABC) transporter
D3H65_RS23450	COG0577	efflux transmembrane transporter activity
D3H65_RS23455	COG0577	efflux transmembrane transporter activity
D3H65_RS23460	COG1136	(ABC) transporter
D3H65_RS23505	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D3H65_RS23510	COG1649	PFAM Uncharacterised BCR, COG1649
D3H65_RS23525	COG0535	radical SAM domain protein
D3H65_RS23535	COG3757	hydrolase, family 25
D3H65_RS23575	COG1082	Xylose isomerase domain protein TIM barrel
D3H65_RS23585	COG0673	inositol 2-dehydrogenase activity
D3H65_RS23595	COG4654	Cytochrome c, class I
D3H65_RS23615	COG1082	Xylose isomerase domain protein TIM barrel
D3H65_RS23680	COG2989	Protein conserved in bacteria
D3H65_RS23685	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D3H65_RS23710	COG3541	Predicted nucleotidyltransferase
D3H65_RS23770	COG0328	RNA-DNA hybrid ribonuclease activity
D3H65_RS23805	COG4942	peptidase
D3H65_RS23820	COG4181	ATPase activity
D3H65_RS23840	COG2169	Transcriptional regulator
D3H65_RS23855	COG4206	TonB-dependent receptor
D3H65_RS23855	COG1629	transport
D3H65_RS23860	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
D3H65_RS23875	COG0366	Alpha amylase catalytic
D3H65_RS23890	COG1595	DNA-templated transcription, initiation
D3H65_RS23900	COG2140	Oxalate decarboxylase
D3H65_RS23910	COG0596	Alpha beta hydrolase
D3H65_RS23920	COG3279	Response regulator of the LytR AlgR family
D3H65_RS23945	COG0450	alkyl hydroperoxide reductase
D3H65_RS23960	COG1349	DNA-binding transcription factor activity
D3H65_RS23965	COG4206	TonB-dependent receptor
D3H65_RS23965	COG1629	transport
D3H65_RS23975	COG2271	Major facilitator Superfamily
D3H65_RS23980	COG2081	HI0933 family
D3H65_RS23990	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
D3H65_RS23995	COG2814	Major facilitator Superfamily
D3H65_RS24000	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D3H65_RS24005	COG1070	Carbohydrate kinase
D3H65_RS24010	COG1070	Carbohydrate kinase
D3H65_RS24065	COG2205	protein histidine kinase activity
D3H65_RS24065	COG0784	Response regulator, receiver
D3H65_RS24075	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D3H65_RS24105	COG4206	TonB-dependent receptor
D3H65_RS24105	COG1629	transport
D3H65_RS24140	COG1472	Belongs to the glycosyl hydrolase 3 family
D3H65_RS24145	COG3119	arylsulfatase activity
D3H65_RS24165	COG1629	transport
D3H65_RS24165	COG4206	TonB-dependent receptor
D3H65_RS24180	COG3396	Phenylacetate-CoA oxygenase
D3H65_RS24185	COG3460	Phenylacetate-CoA oxygenase
D3H65_RS24190	COG3396	Phenylacetate-CoA oxygenase
D3H65_RS24195	COG2151	metal-sulfur cluster biosynthetic enzyme
D3H65_RS24200	COG1024	Enoyl-CoA hydratase
D3H65_RS24205	COG2050	protein possibly involved in aromatic compounds catabolism
D3H65_RS24215	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
D3H65_RS24235	COG3591	Belongs to the peptidase S1B family
D3H65_RS24245	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
D3H65_RS24250	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
D3H65_RS24250	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D3H65_RS24255	COG0215	cysteine-tRNA ligase activity
D3H65_RS24275	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D3H65_RS24280	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D3H65_RS24295	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D3H65_RS24315	COG1309	transcriptional regulator
D3H65_RS24320	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D3H65_RS24325	COG1011	Hydrolase
D3H65_RS24335	COG0779	Required for maturation of 30S ribosomal subunits
D3H65_RS24340	COG0195	Participates in both transcription termination and antitermination
D3H65_RS24345	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
D3H65_RS24350	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D3H65_RS24355	COG3851	Histidine kinase
D3H65_RS24360	COG2197	response regulator
D3H65_RS24370	COG2197	response regulator
D3H65_RS24490	COG0463	Glycosyl transferase, family 2
D3H65_RS24495	COG2353	YceI-like domain
D3H65_RS24505	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D3H65_RS24510	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
D3H65_RS24515	COG1137	ATPase activity
D3H65_RS24525	COG1028	Short-chain dehydrogenase reductase Sdr
D3H65_RS24535	COG2030	dehydratase
D3H65_RS24535	COG1012	belongs to the aldehyde dehydrogenase family
D3H65_RS24550	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D3H65_RS24575	COG0563	adenylate kinase activity
D3H65_RS24580	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D3H65_RS24585	COG1629	transport
D3H65_RS24585	COG4206	TonB-dependent receptor
D3H65_RS24625	COG4206	TonB-dependent receptor
D3H65_RS24625	COG1629	transport
D3H65_RS24630	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
D3H65_RS24645	COG1022	Amp-dependent synthetase and ligase
D3H65_RS24650	COG0076	glutamate decarboxylase activity
D3H65_RS24655	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D3H65_RS24670	COG2205	protein histidine kinase activity
D3H65_RS24675	COG0745	RESPONSE REGULATOR receiver
D3H65_RS24685	COG0640	Transcriptional regulator
D3H65_RS24695	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D3H65_RS24705	COG2151	metal-sulfur cluster biosynthetic enzyme
D3H65_RS24710	COG2166	iron-sulfur cluster assembly
D3H65_RS24715	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D3H65_RS24720	COG0719	Fe-S assembly protein
D3H65_RS24725	COG0396	ATPase activity
D3H65_RS24730	COG0719	Fe-S assembly protein
D3H65_RS24735	COG0316	Belongs to the HesB IscA family
D3H65_RS24755	COG2814	Major facilitator Superfamily
D3H65_RS24760	COG1597	lipid kinase activity
D3H65_RS24770	COG1595	DNA-templated transcription, initiation
D3H65_RS24780	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
D3H65_RS24790	COG1472	Belongs to the glycosyl hydrolase 3 family
D3H65_RS24795	COG0288	reversible hydration of carbon dioxide
D3H65_RS24800	COG1131	(ABC) transporter
D3H65_RS24810	COG0148	phosphopyruvate hydratase activity
D3H65_RS24825	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D3H65_RS24850	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
D3H65_RS24850	COG0674	pyruvate-flavodoxin oxidoreductase activity
D3H65_RS24860	COG0288	reversible hydration of carbon dioxide
D3H65_RS24880	COG0477	Major facilitator Superfamily
D3H65_RS24885	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D3H65_RS24925	COG0156	8-amino-7-oxononanoate synthase activity
D3H65_RS24935	COG1250	3-hydroxyacyl-CoA dehydrogenase
D3H65_RS24940	COG1214	PFAM Peptidase M22, glycoprotease
D3H65_RS24945	COG0640	Transcriptional regulator
D3H65_RS24950	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D3H65_RS24950	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D3H65_RS24965	COG4585	Histidine kinase
D3H65_RS24965	COG2203	Gaf domain
D3H65_RS24985	COG1660	Displays ATPase and GTPase activities
D3H65_RS24995	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
D3H65_RS25010	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
D3H65_RS25025	COG2378	regulation of single-species biofilm formation
D3H65_RS25030	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
D3H65_RS25040	COG2304	oxidoreductase activity
D3H65_RS25085	COG3618	amidohydrolase
D3H65_RS25090	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D3H65_RS25090	COG1703	isobutyryl-CoA mutase activity
D3H65_RS25090	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D3H65_RS25095	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D3H65_RS25105	COG0693	protein deglycase activity
D3H65_RS25115	COG0513	Belongs to the DEAD box helicase family
D3H65_RS25125	COG0232	Belongs to the dGTPase family. Type 2 subfamily
D3H65_RS25150	COG3119	arylsulfatase activity
D3H65_RS25160	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
D3H65_RS25200	COG2197	response regulator
D3H65_RS25260	COG1690	Belongs to the RtcB family
D3H65_RS25325	COG4122	O-methyltransferase activity
D3H65_RS25335	COG1088	dTDP-glucose 4,6-dehydratase activity
D3H65_RS25345	COG1216	Glycosyl transferase, family 2
D3H65_RS25350	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D3H65_RS25355	COG0438	transferase activity, transferring glycosyl groups
D3H65_RS25360	COG0438	transferase activity, transferring glycosyl groups
D3H65_RS25365	COG0275	rRNA processing
D3H65_RS25380	COG0667	Aldo Keto reductase
D3H65_RS25400	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D3H65_RS25405	COG1216	Glycosyl transferase, family 2
D3H65_RS25405	COG0463	Glycosyl transferase, family 2
D3H65_RS25425	COG0367	asparagine synthase
D3H65_RS25435	COG0110	maltose O-acetyltransferase activity
D3H65_RS25445	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
D3H65_RS25450	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D3H65_RS25455	COG4464	protein tyrosine phosphatase activity
D3H65_RS25460	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D3H65_RS25465	COG0113	porphobilinogen synthase activity
D3H65_RS25470	COG0408	coproporphyrinogen oxidase activity
D3H65_RS25480	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
D3H65_RS25490	COG0181	hydroxymethylbilane synthase activity
D3H65_RS25495	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
D3H65_RS25500	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
D3H65_RS25515	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
D3H65_RS25525	COG3279	Response regulator of the LytR AlgR family
D3H65_RS25530	COG3275	phosphorelay sensor kinase activity
D3H65_RS25540	COG1028	Short-chain dehydrogenase reductase Sdr
D3H65_RS25550	COG1132	(ABC) transporter
D3H65_RS25555	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
D3H65_RS25570	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
D3H65_RS25575	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D3H65_RS25580	COG0233	cytoplasmic translational termination
D3H65_RS25585	COG2326	polyphosphate kinase activity
D3H65_RS25590	COG1970	mechanosensitive ion channel activity
D3H65_RS25600	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
D3H65_RS25610	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
D3H65_RS25615	COG3275	phosphorelay sensor kinase activity
D3H65_RS25620	COG3279	Response regulator of the LytR AlgR family
D3H65_RS25650	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
D3H65_RS25670	COG0509	glycine decarboxylation via glycine cleavage system
D3H65_RS25695	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
D3H65_RS25705	COG1381	Involved in DNA repair and RecF pathway recombination
D3H65_RS25720	COG1629	transport
D3H65_RS25720	COG4206	TonB-dependent receptor
D3H65_RS25765	COG3328	transposase activity
D3H65_RS25775	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D3H65_RS25785	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D3H65_RS25790	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D3H65_RS25795	COG0739	heme binding
D3H65_RS25805	COG4771	TonB-dependent receptor
D3H65_RS25815	COG4558	Periplasmic binding protein
D3H65_RS25820	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D3H65_RS25825	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
D3H65_RS25860	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
D3H65_RS25880	COG2204	response regulator
D3H65_RS25895	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
D3H65_RS25900	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
D3H65_RS25905	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
D3H65_RS25915	COG2205	protein histidine kinase activity
D3H65_RS25920	COG5002	protein histidine kinase activity
D3H65_RS25945	COG4206	TonB-dependent receptor
D3H65_RS25945	COG1629	transport
D3H65_RS25975	COG1629	transport
D3H65_RS25975	COG4206	TonB-dependent receptor
D3H65_RS25990	COG2095	MarC family integral membrane protein
D3H65_RS26000	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
D3H65_RS26005	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
D3H65_RS26045	COG0531	amino acid
D3H65_RS26050	COG0626	cystathionine gamma-synthase activity
D3H65_RS26070	COG0577	efflux transmembrane transporter activity
D3H65_RS26070	COG1136	(ABC) transporter
D3H65_RS26075	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
D3H65_RS26085	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D3H65_RS26105	COG1331	Highly conserved protein containing a thioredoxin domain
D3H65_RS26110	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D3H65_RS26130	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D3H65_RS26135	COG0768	penicillin binding
D3H65_RS26140	COG0772	Belongs to the SEDS family
D3H65_RS26145	COG0768	penicillin binding
D3H65_RS26155	COG1792	Involved in formation and maintenance of cell shape
D3H65_RS26160	COG1077	Cell shape determining protein MreB Mrl
D3H65_RS26185	COG0322	excinuclease ABC activity
D3H65_RS26205	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
D3H65_RS26220	COG0023	Translation Initiation Factor
D3H65_RS26230	COG0473	3-isopropylmalate dehydrogenase activity
D3H65_RS26235	COG2967	ApaG domain
D3H65_RS26245	COG3104	oligopeptide transport
D3H65_RS26250	COG0151	Belongs to the GarS family
D3H65_RS26255	COG3483	tryptophan 2,3-dioxygenase activity
D3H65_RS26260	COG3958	Transketolase
D3H65_RS26265	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D3H65_RS26275	COG0306	phosphate transporter
D3H65_RS26325	COG1629	transport
D3H65_RS26325	COG4206	TonB-dependent receptor
D3H65_RS26360	COG0671	phosphoesterase, PA-phosphatase related
D3H65_RS26370	COG0668	transmembrane transport
D3H65_RS26375	COG5002	protein histidine kinase activity
D3H65_RS26380	COG0745	RESPONSE REGULATOR receiver
D3H65_RS26390	COG1132	(ABC) transporter
D3H65_RS26405	COG0356	it plays a direct role in the translocation of protons across the membrane
D3H65_RS26410	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D3H65_RS26415	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D3H65_RS26420	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D3H65_RS26425	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
D3H65_RS26440	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D3H65_RS26455	COG0423	glycine-tRNA ligase activity
D3H65_RS26470	COG1694	Mazg nucleotide pyrophosphohydrolase
D3H65_RS26475	COG1490	D-aminoacyl-tRNA deacylase activity
D3H65_RS26480	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
D3H65_RS26490	COG1858	cytochrome C peroxidase
D3H65_RS26495	COG0346	lactoylglutathione lyase activity
D3H65_RS26500	COG1104	cysteine desulfurase activity
D3H65_RS26520	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D3H65_RS26525	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D3H65_RS26580	COG1024	Enoyl-CoA hydratase
D3H65_RS26610	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D3H65_RS26620	COG0726	polysaccharide deacetylase
D3H65_RS26630	COG0084	hydrolase, TatD family'
D3H65_RS26640	COG2827	Endonuclease containing a URI domain
D3H65_RS26660	COG2379	hydroxypyruvate reductase
D3H65_RS26665	COG2610	gluconate transmembrane transporter activity
D3H65_RS26695	COG0631	protein serine/threonine phosphatase activity
D3H65_RS26700	COG0515	serine threonine protein kinase
D3H65_RS26700	COG2815	serine threonine protein kinase
D3H65_RS26705	COG0772	Belongs to the SEDS family
D3H65_RS26715	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D3H65_RS26745	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
D3H65_RS26765	COG3604	Transcriptional regulator
D3H65_RS26795	COG2353	YceI-like domain
D3H65_RS26800	COG0346	lactoylglutathione lyase activity
D3H65_RS26805	COG0346	lactoylglutathione lyase activity
D3H65_RS26835	COG5520	Belongs to the glycosyl hydrolase 30 family
D3H65_RS26885	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
D3H65_RS26885	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
D3H65_RS26920	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D3H65_RS26925	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D3H65_RS26935	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
D3H65_RS26950	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D3H65_RS26955	COG2270	Major facilitator Superfamily
D3H65_RS26960	COG1968	undecaprenyl-diphosphatase activity
D3H65_RS26970	COG2177	Part of the ABC transporter FtsEX involved in
D3H65_RS26975	COG0495	leucyl-tRNA aminoacylation
D3H65_RS27030	COG2255	four-way junction helicase activity
D3H65_RS27050	COG0433	COG0433 Predicted ATPase
D3H65_RS27055	COG0514	ATP-dependent DNA helicase (RecQ)
D3H65_RS27065	COG2217	Heavy metal translocating P-type atpase
D3H65_RS27085	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D3H65_RS27090	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D3H65_RS27090	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
D3H65_RS27095	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D3H65_RS27100	COG1078	dGTPase activity
D3H65_RS27105	COG2204	response regulator
D3H65_RS27115	COG1234	tRNA 3'-trailer cleavage
D3H65_RS27125	COG1960	acyl-CoA dehydrogenase activity
D3H65_RS27130	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
D3H65_RS27140	COG0740	serine-type endopeptidase activity
D3H65_RS27150	COG0544	peptidyl-prolyl cis-trans isomerase activity
D3H65_RS27160	COG3279	Response regulator of the LytR AlgR family
D3H65_RS27180	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D3H65_RS27185	COG4206	TonB-dependent receptor
D3H65_RS27185	COG1629	transport
D3H65_RS27195	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
D3H65_RS27205	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D3H65_RS27210	COG0739	heme binding
D3H65_RS27210	COG0741	lytic transglycosylase activity
D3H65_RS27210	COG1196	nuclear chromosome segregation
D3H65_RS27215	COG0154	amidase activity
D3H65_RS27220	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D3H65_RS27225	COG0335	large ribosomal subunit rRNA binding
D3H65_RS27230	COG1418	mRNA catabolic process
D3H65_RS27235	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D3H65_RS27290	COG0305	Participates in initiation and elongation during chromosome replication
D3H65_RS27310	COG0861	Integral membrane protein TerC family
D3H65_RS27315	COG0167	dihydroorotate dehydrogenase activity
D3H65_RS27320	COG0183	Belongs to the thiolase family
D3H65_RS27335	COG2197	response regulator
D3H65_RS27340	COG5002	protein histidine kinase activity
D3H65_RS27345	COG4771	TonB-dependent receptor
D3H65_RS27365	COG1132	(ABC) transporter
D3H65_RS27380	COG2244	polysaccharide biosynthetic process
D3H65_RS27435	COG0606	chelatase, subunit chli
D3H65_RS27440	COG0308	aminopeptidase N
D3H65_RS27445	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
D3H65_RS27475	COG4977	sequence-specific DNA binding
D3H65_RS27485	COG2226	methyltransferase
D3H65_RS27495	COG3424	synthase
D3H65_RS27530	COG1090	epimerase
D3H65_RS27545	COG0218	Necessary for normal cell division and for the maintenance of normal septation
D3H65_RS27560	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
D3H65_RS27565	COG1309	transcriptional regulator
D3H65_RS27705	COG0277	FAD linked oxidase domain protein
D3H65_RS27720	COG4145	pantothenate transmembrane transporter activity
D3H65_RS27725	COG1611	Belongs to the LOG family
D3H65_RS27735	COG1388	LysM domain
D3H65_RS27735	COG1705	Flagellar rod assembly protein muramidase FlgJ
D3H65_RS27745	COG2304	oxidoreductase activity
D3H65_RS27750	COG0484	heat shock protein binding
D3H65_RS27755	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
D3H65_RS27770	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D3H65_RS27845	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
D3H65_RS27860	COG0497	DNA recombination
D3H65_RS27875	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D3H65_RS27885	COG1136	(ABC) transporter
D3H65_RS27890	COG2096	Adenosyltransferase
D3H65_RS27895	COG1136	(ABC) transporter
D3H65_RS27900	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D3H65_RS27905	COG0180	Tryptophanyl-tRNA synthetase
D3H65_RS27910	COG1428	Deoxynucleoside kinase
D3H65_RS27930	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
D3H65_RS27935	COG0006	proline dipeptidase activity
D3H65_RS27940	COG1183	phosphatidylcholine synthase activity
D3H65_RS27950	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
D3H65_RS27975	COG0357	Ribosomal RNA small subunit methyltransferase G
D3H65_RS27985	COG0343	queuine tRNA-ribosyltransferase activity
D3H65_RS28020	COG1074	ATP-dependent DNA helicase activity
D3H65_RS28025	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
D3H65_RS28030	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D3H65_RS28035	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
D3H65_RS28040	COG2169	Transcriptional regulator
D3H65_RS28045	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
D3H65_RS28070	COG2814	Major facilitator Superfamily
D3H65_RS28085	COG2755	lipolytic protein G-D-S-L family
D3H65_RS28085	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
D3H65_RS28090	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D3H65_RS28115	COG4206	TonB-dependent receptor
D3H65_RS28115	COG1629	transport
D3H65_RS28135	COG4206	TonB-dependent receptor
D3H65_RS28155	COG0784	Response regulator, receiver
D3H65_RS28215	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
D3H65_RS28325	COG4206	TonB-dependent receptor
D3H65_RS28325	COG1629	transport
D3H65_RS28400	COG0667	Aldo Keto reductase
D3H65_RS28405	COG1228	amidohydrolase
D3H65_RS28425	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D3H65_RS28445	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
D3H65_RS28450	COG0277	FAD linked oxidase domain protein
D3H65_RS28460	COG0560	Phosphoserine phosphatase
D3H65_RS28500	COG1678	Uncharacterized ACR, COG1678
D3H65_RS28510	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
D3H65_RS28520	COG2001	Belongs to the MraZ family
D3H65_RS28525	COG0275	rRNA processing
D3H65_RS28540	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D3H65_RS28545	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D3H65_RS28550	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
D3H65_RS28560	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D3H65_RS28565	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D3H65_RS28580	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
D3H65_RS28590	COG1090	epimerase
D3H65_RS28610	COG1024	Enoyl-CoA hydratase
D3H65_RS28610	COG1250	3-hydroxyacyl-CoA dehydrogenase
D3H65_RS28625	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D3H65_RS28625	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D3H65_RS28645	COG1619	proteins homologs of microcin C7 resistance protein MccF
D3H65_RS28660	COG1619	proteins homologs of microcin C7 resistance protein MccF
D3H65_RS28665	COG0583	DNA-binding transcription factor activity
D3H65_RS28680	COG3158	transport of potassium into the cell
D3H65_RS28695	COG0047	phosphoribosylformylglycinamidine synthase activity
D3H65_RS28735	COG2972	Histidine kinase
D3H65_RS28735	COG0745	RESPONSE REGULATOR receiver
D3H65_RS28740	COG3279	Response regulator of the LytR AlgR family
D3H65_RS28750	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D3H65_RS28780	COG4152	abc transporter atp-binding protein
D3H65_RS28785	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
D3H65_RS28790	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D3H65_RS28845	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D3H65_RS28870	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
D3H65_RS28890	COG2310	stress, protein
D3H65_RS28900	COG4245	von Willebrand factor, type A
D3H65_RS28945	COG0861	Integral membrane protein TerC family
D3H65_RS28960	COG1388	LysM domain
D3H65_RS28960	COG4932	domain protein
D3H65_RS28960	COG2373	Large extracellular alpha-helical protein
D3H65_RS28975	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
D3H65_RS28980	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D3H65_RS29005	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D3H65_RS29010	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
D3H65_RS29015	COG0066	3-isopropylmalate dehydratase activity
D3H65_RS29020	COG0473	3-isopropylmalate dehydrogenase activity
D3H65_RS29025	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D3H65_RS29035	COG0028	Belongs to the TPP enzyme family
D3H65_RS29045	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
D3H65_RS29050	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D3H65_RS29065	COG2308	Evidence 4 Homologs of previously reported genes of
D3H65_RS29075	COG0069	glutamate synthase activity
D3H65_RS29075	COG0070	glutamate synthase
D3H65_RS29075	COG0067	glutamate synthase
D3H65_RS29085	COG0004	ammonium transporteR
D3H65_RS29100	COG0460	homoserine dehydrogenase
D3H65_RS29100	COG0527	aspartate kinase activity
D3H65_RS29105	COG0083	homoserine kinase activity
D3H65_RS29115	COG0460	homoserine dehydrogenase
D3H65_RS29120	COG0626	cystathionine gamma-synthase activity
D3H65_RS29135	COG2885	chlorophyll binding
D3H65_RS29140	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D3H65_RS29160	COG2153	protein acetylation
D3H65_RS29165	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D3H65_RS29190	COG2197	response regulator
D3H65_RS29200	COG0415	Belongs to the DNA photolyase family
D3H65_RS29205	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
D3H65_RS29210	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D3H65_RS29225	COG0302	gtp cyclohydrolase
D3H65_RS29230	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
D3H65_RS29245	COG0626	cystathionine gamma-synthase activity
D3H65_RS29250	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D3H65_RS29255	COG0632	four-way junction helicase activity
D3H65_RS29275	COG4221	oxidoreductase activity
D3H65_RS29285	COG0596	Alpha beta hydrolase
D3H65_RS29295	COG0517	IMP dehydrogenase activity
D3H65_RS29295	COG0516	GMP reductase activity
D3H65_RS29300	COG0758	DNA mediated transformation
D3H65_RS29310	COG0602	queuosine metabolic process
D3H65_RS29320	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
D3H65_RS29335	COG1629	transport
D3H65_RS29335	COG4206	TonB-dependent receptor
D3H65_RS29360	COG4206	TonB-dependent receptor
D3H65_RS29360	COG1629	transport
D3H65_RS29375	COG2003	Belongs to the UPF0758 family
D3H65_RS29380	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D3H65_RS29385	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
D3H65_RS29390	COG0193	aminoacyl-tRNA hydrolase activity
D3H65_RS29395	COG0179	Fumarylacetoacetate (FAA) hydrolase
D3H65_RS29400	COG0022	dehydrogenase e1 component
D3H65_RS29415	COG2207	Transcriptional regulator
D3H65_RS29415	COG1917	Cupin 2, conserved barrel domain protein
D3H65_RS29470	COG0667	Aldo Keto reductase
D3H65_RS29475	COG4251	negative regulation of phosphorylation
D3H65_RS29485	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D3H65_RS29495	COG1082	Xylose isomerase domain protein TIM barrel
D3H65_RS29500	COG3279	Response regulator of the LytR AlgR family
D3H65_RS29505	COG3275	phosphorelay sensor kinase activity
D3H65_RS29530	COG1028	Short-chain dehydrogenase reductase Sdr
D3H65_RS29535	COG1609	Transcriptional regulator
D3H65_RS29545	COG4206	TonB-dependent receptor
D3H65_RS29545	COG1629	transport
D3H65_RS29555	COG3661	Belongs to the glycosyl hydrolase 67 family
D3H65_RS29560	COG1609	Transcriptional regulator
D3H65_RS29565	COG1312	Catalyzes the dehydration of D-mannonate
D3H65_RS29610	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
D3H65_RS29700	COG0667	Aldo Keto reductase
D3H65_RS29710	COG0586	Pfam SNARE associated Golgi protein
D3H65_RS29715	COG0861	Integral membrane protein TerC family
D3H65_RS29720	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D3H65_RS29780	COG4989	oxidoreductase activity
D3H65_RS29845	COG3537	Alpha-1,2-mannosidase
D3H65_RS29850	COG3507	Belongs to the glycosyl hydrolase 43 family
D3H65_RS29965	COG0642	Histidine kinase
D3H65_RS29970	COG0745	RESPONSE REGULATOR receiver
D3H65_RS29980	COG1368	sulfuric ester hydrolase activity
D3H65_RS29990	COG0671	phosphoesterase, PA-phosphatase related
D3H65_RS29995	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D3H65_RS30020	COG2201	protein-glutamate methylesterase activity
D3H65_RS30025	COG1230	cation diffusion facilitator family transporter
D3H65_RS30030	COG4977	sequence-specific DNA binding
D3H65_RS30030	COG1917	Cupin 2, conserved barrel domain protein
D3H65_RS30035	COG1733	regulation of RNA biosynthetic process
D3H65_RS30060	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
D3H65_RS30080	COG4206	TonB-dependent receptor
D3H65_RS30080	COG1629	transport
D3H65_RS30095	COG3858	chitin binding
D3H65_RS30100	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
D3H65_RS30105	COG4260	virion core protein, lumpy skin disease virus
D3H65_RS30115	COG3511	phospholipase C
D3H65_RS30135	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D3H65_RS30145	COG2814	Major facilitator Superfamily
D3H65_RS30155	COG1733	regulation of RNA biosynthetic process
D3H65_RS30170	COG1629	transport
D3H65_RS30170	COG4206	TonB-dependent receptor
D3H65_RS30195	COG1629	transport
D3H65_RS30195	COG4206	TonB-dependent receptor
D3H65_RS30210	COG0457	Tetratricopeptide repeat
D3H65_RS30235	COG2353	YceI-like domain
D3H65_RS30260	COG0251	oxidation-reduction process
D3H65_RS30280	COG2207	Transcriptional regulator
D3H65_RS30280	COG1917	Cupin 2, conserved barrel domain protein
D3H65_RS30290	COG4206	TonB-dependent receptor
D3H65_RS30290	COG1629	transport
D3H65_RS30315	COG2133	pyrroloquinoline quinone binding
D3H65_RS30320	COG0300	oxidoreductase activity
D3H65_RS30345	COG3964	amidohydrolase
D3H65_RS30355	COG1921	L-seryl-tRNASec selenium transferase activity
D3H65_RS30365	COG4993	Dehydrogenase
D3H65_RS30380	COG4206	TonB-dependent receptor
D3H65_RS30380	COG1629	transport
D3H65_RS30415	COG0697	spore germination
D3H65_RS30420	COG2171	N-acyltransferase activity
D3H65_RS30425	COG0009	L-threonylcarbamoyladenylate synthase
D3H65_RS30445	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
D3H65_RS30460	COG0442	prolyl-tRNA aminoacylation
D3H65_RS30465	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
D3H65_RS30470	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
D3H65_RS30475	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
D3H65_RS30490	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D3H65_RS30495	COG3876	Protein conserved in bacteria
D3H65_RS30500	COG1047	Peptidyl-prolyl cis-trans
D3H65_RS30515	COG2195	Cleaves the N-terminal amino acid of tripeptides
D3H65_RS30525	COG0492	ferredoxin-NADP+ reductase activity
D3H65_RS30530	COG4206	TonB-dependent receptor
D3H65_RS30530	COG1629	transport
D3H65_RS30545	COG0330	HflC and HflK could
D3H65_RS30550	COG0811	peptide transport
D3H65_RS30560	COG0277	FAD linked oxidase domain protein
D3H65_RS30565	COG2890	protein-(glutamine-N5) methyltransferase activity
D3H65_RS30570	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D3H65_RS30570	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D3H65_RS30575	COG1739	Uncharacterized protein family UPF0029
D3H65_RS30580	COG1250	3-hydroxyacyl-CoA dehydrogenase
D3H65_RS30620	COG4372	Transposase
D3H65_RS30700	COG0489	protein tyrosine kinase activity
D3H65_RS30705	COG0584	glycerophosphoryl diester phosphodiesterase
D3H65_RS30710	COG1028	Short-chain dehydrogenase reductase Sdr
D3H65_RS30720	COG3844	kynureninase activity
D3H65_RS30725	COG0284	orotidine-5'-phosphate decarboxylase activity
D3H65_RS30745	COG1595	DNA-templated transcription, initiation
D3H65_RS30760	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
D3H65_RS30765	COG2363	Small membrane protein
D3H65_RS30770	COG3850	Histidine kinase
D3H65_RS30775	COG1674	ftsk spoiiie
D3H65_RS30785	COG0163	prenyltransferase activity
D3H65_RS30790	COG4232	protein-disulfide reductase activity
D3H65_RS30800	COG0156	8-amino-7-oxononanoate synthase activity
D3H65_RS30810	COG0612	Peptidase, M16
D3H65_RS30835	COG1830	Aldolase
D3H65_RS30840	COG0191	fructose-bisphosphate aldolase activity
D3H65_RS30850	COG0346	lactoylglutathione lyase activity
D3H65_RS30875	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D3H65_RS30880	COG1136	(ABC) transporter
D3H65_RS30880	COG0577	efflux transmembrane transporter activity
D3H65_RS30900	COG2183	response to ionizing radiation
D3H65_RS30905	COG5002	protein histidine kinase activity
D3H65_RS30910	COG0745	RESPONSE REGULATOR receiver
D3H65_RS30940	COG1595	DNA-templated transcription, initiation
D3H65_RS30950	COG0793	Belongs to the peptidase S41A family
D3H65_RS30960	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
D3H65_RS30995	COG0077	Prephenate dehydratase
D3H65_RS30995	COG1605	Chorismate mutase
D3H65_RS31000	COG0436	Aminotransferase
D3H65_RS31010	COG0513	Belongs to the DEAD box helicase family
D3H65_RS31015	COG2877	3-deoxy-8-phosphooctulonate synthase activity
D3H65_RS31025	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
D3H65_RS31035	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
D3H65_RS31050	COG2989	Protein conserved in bacteria
D3H65_RS31060	COG2885	chlorophyll binding
D3H65_RS31065	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
D3H65_RS31100	COG0577	efflux transmembrane transporter activity
D3H65_RS31100	COG1136	(ABC) transporter
D3H65_RS31105	COG1136	(ABC) transporter
D3H65_RS31110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D3H65_RS31125	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D3H65_RS31150	COG2972	Histidine kinase
D3H65_RS31155	COG3279	Response regulator of the LytR AlgR family
D3H65_RS31165	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D3H65_RS31170	COG2972	Histidine kinase
D3H65_RS31175	COG3279	Response regulator of the LytR AlgR family
D3H65_RS31185	COG0697	spore germination
D3H65_RS31210	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
D3H65_RS31215	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D3H65_RS31235	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D3H65_RS31240	COG1131	(ABC) transporter
D3H65_RS31245	COG1131	(ABC) transporter
D3H65_RS31250	COG0842	Transport permease protein
D3H65_RS31255	COG0842	Transport permease protein
D3H65_RS31265	COG1566	PFAM secretion protein HlyD family protein
D3H65_RS31275	COG0702	epimerase
D3H65_RS31285	COG0667	Aldo Keto reductase
D3H65_RS31295	COG1309	transcriptional regulator
D3H65_RS31300	COG2814	Major facilitator Superfamily
D3H65_RS31310	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D3H65_RS31315	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D3H65_RS31320	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
D3H65_RS31325	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
D3H65_RS31330	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
D3H65_RS31335	COG0202	RNA polymerase activity
D3H65_RS31340	COG0203	ribosomal protein L17
D3H65_RS31345	COG0505	Belongs to the CarA family
D3H65_RS31350	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
D3H65_RS31360	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D3H65_RS31375	COG1253	flavin adenine dinucleotide binding
D3H65_RS31420	COG1104	cysteine desulfurase activity
D3H65_RS31430	COG1070	Carbohydrate kinase
D3H65_RS31445	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
D3H65_RS31460	COG3385	transposase activity
D3H65_RS31465	COG1607	acyl-coa hydrolase
D3H65_RS31470	COG4948	Mandelate Racemase Muconate Lactonizing
D3H65_RS31480	COG0860	N-Acetylmuramoyl-L-alanine amidase
D3H65_RS31485	COG0412	Dienelactone hydrolase
D3H65_RS31500	COG3507	Belongs to the glycosyl hydrolase 43 family
D3H65_RS31520	COG3525	Glycosyl hydrolase, family 20, catalytic domain
D3H65_RS31525	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
D3H65_RS31545	COG4206	TonB-dependent receptor
D3H65_RS31545	COG1629	transport
D3H65_RS31550	COG1349	DNA-binding transcription factor activity
D3H65_RS31560	COG1570	exodeoxyribonuclease VII activity
D3H65_RS31590	COG3220	belongs to the UPF0276 family
D3H65_RS31610	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
D3H65_RS31660	COG0714	Associated with various cellular activities
D3H65_RS31670	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
D3H65_RS31680	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D3H65_RS31685	COG0577	efflux transmembrane transporter activity
D3H65_RS31700	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D3H65_RS31715	COG1051	belongs to the nudix hydrolase family
D3H65_RS31720	COG1196	nuclear chromosome segregation
D3H65_RS31725	COG1528	Iron-storage protein
D3H65_RS31740	COG0006	proline dipeptidase activity
D3H65_RS31810	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
D3H65_RS31830	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D3H65_RS31830	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D3H65_RS31845	COG0405	Gamma-glutamyltransferase
D3H65_RS31905	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
D3H65_RS31920	COG3525	Glycosyl hydrolase, family 20, catalytic domain
D3H65_RS31935	COG1506	peptidase
D3H65_RS31940	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
D3H65_RS31945	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
D3H65_RS31950	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D3H65_RS31970	COG0131	Imidazoleglycerol-phosphate dehydratase
D3H65_RS31970	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
D3H65_RS31975	COG2388	GCN5-related N-acetyl-transferase
D3H65_RS31985	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D3H65_RS31995	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D3H65_RS32000	COG0134	indole-3-glycerol-phosphate synthase activity
D3H65_RS32005	COG0135	phosphoribosylanthranilate isomerase activity
D3H65_RS32015	COG0133	tryptophan synthase activity
D3H65_RS32020	COG0159	tryptophan synthase activity
D3H65_RS32025	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
D3H65_RS32030	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
D3H65_RS32035	COG0107	imidazoleglycerol-phosphate synthase activity
D3H65_RS32045	COG0140	phosphoribosyl-ATP diphosphatase activity
D3H65_RS32045	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
D3H65_RS32050	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D3H65_RS32065	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
D3H65_RS32105	COG0045	succinate-CoA ligase (ADP-forming) activity
D3H65_RS32150	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D3H65_RS32180	COG0784	Response regulator, receiver
D3H65_RS32190	COG5487	UPF0391 membrane protein
D3H65_RS32205	COG0673	inositol 2-dehydrogenase activity
D3H65_RS32210	COG1028	Short-chain dehydrogenase reductase Sdr
D3H65_RS32220	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
D3H65_RS32225	COG2204	response regulator
D3H65_RS32230	COG4251	negative regulation of phosphorylation
D3H65_RS32235	COG4191	Histidine kinase
D3H65_RS32245	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
D3H65_RS32250	COG3285	dna ligase
D3H65_RS32250	COG1793	dna ligase
D3H65_RS32290	COG0071	Belongs to the small heat shock protein (HSP20) family
D3H65_RS32310	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D3H65_RS32310	COG0723	plastoquinol--plastocyanin reductase activity
D3H65_RS32325	COG1796	DNA polymerase
D3H65_RS32325	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
D3H65_RS32330	COG0211	Belongs to the bacterial ribosomal protein bL27 family
D3H65_RS32335	COG0261	This protein binds to 23S rRNA in the presence of protein L20
D3H65_RS32345	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
D3H65_RS32350	COG0750	zinc metalloprotease
D3H65_RS32375	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
D3H65_RS32405	COG0789	Transcriptional regulator
D3H65_RS32440	COG1733	regulation of RNA biosynthetic process
D3H65_RS32450	COG2226	methyltransferase
D3H65_RS32475	COG4206	TonB-dependent receptor
D3H65_RS32475	COG1629	transport
D3H65_RS32485	COG1595	DNA-templated transcription, initiation
D3H65_RS32490	COG0488	(ABC) transporter
D3H65_RS32520	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D3H65_RS32550	COG4206	TonB-dependent receptor
D3H65_RS32550	COG1629	transport
D3H65_RS32565	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
D3H65_RS32575	COG2814	Major facilitator Superfamily
D3H65_RS32580	COG1446	asparaginase
D3H65_RS32610	COG1858	cytochrome C peroxidase
D3H65_RS32625	COG4771	TonB-dependent receptor
D3H65_RS32660	COG3275	phosphorelay sensor kinase activity
D3H65_RS32690	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate