locus-tag	class	description
FX988_RS00005	COG0427	acetyl-CoA hydrolase
FX988_RS00020	COG2205	protein histidine kinase activity
FX988_RS00020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FX988_RS00025	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FX988_RS00045	COG1115	amino acid carrier protein
FX988_RS00085	COG0193	aminoacyl-tRNA hydrolase activity
FX988_RS00090	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FX988_RS00095	COG0668	transmembrane transport
FX988_RS00100	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FX988_RS00110	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FX988_RS00115	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
FX988_RS00120	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
FX988_RS00125	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FX988_RS00130	COG2890	protein-(glutamine-N5) methyltransferase activity
FX988_RS00135	COG3437	response regulator, receiver
FX988_RS00135	COG0784	Response regulator, receiver
FX988_RS00145	COG2912	Transglutaminase-like superfamily
FX988_RS00155	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FX988_RS00160	COG0156	8-amino-7-oxononanoate synthase activity
FX988_RS00165	COG2226	methyltransferase
FX988_RS00190	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FX988_RS00195	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
FX988_RS00200	COG1074	ATP-dependent DNA helicase activity
FX988_RS00205	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FX988_RS00225	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FX988_RS00260	COG2203	Gaf domain
FX988_RS00260	COG2199	diguanylate cyclase activity
FX988_RS00270	COG3706	GGDEF domain
FX988_RS00270	COG0745	RESPONSE REGULATOR receiver
FX988_RS00275	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FX988_RS00285	COG1196	nuclear chromosome segregation
FX988_RS00295	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FX988_RS00310	COG0658	competence protein
FX988_RS00310	COG2333	competence protein COMEC
FX988_RS00315	COG1132	(ABC) transporter
FX988_RS00320	COG1663	tetraacyldisaccharide 4'-kinase activity
FX988_RS00325	COG2835	tetraacyldisaccharide 4'-kinase activity
FX988_RS00330	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
FX988_RS00345	COG3706	GGDEF domain
FX988_RS00365	COG0583	DNA-binding transcription factor activity
FX988_RS00375	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
FX988_RS00390	COG0372	Belongs to the citrate synthase family
FX988_RS00395	COG2009	succinate dehydrogenase
FX988_RS00400	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
FX988_RS00405	COG1053	succinate dehydrogenase
FX988_RS00415	COG0567	Dehydrogenase, E1 component
FX988_RS00420	COG0508	dehydrogenase complex catalyzes the overall conversion of
FX988_RS00425	COG0045	succinate-CoA ligase (ADP-forming) activity
FX988_RS00450	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FX988_RS00460	COG4771	TonB-dependent receptor
FX988_RS00470	COG1960	acyl-CoA dehydrogenase activity
FX988_RS00505	COG4946	Tricorn protease homolog
FX988_RS00505	COG1506	peptidase
FX988_RS00505	COG0823	Involved in the tonB-independent uptake of proteins
FX988_RS00510	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
FX988_RS00525	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
FX988_RS00530	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
FX988_RS00545	COG1028	Short-chain dehydrogenase reductase Sdr
FX988_RS00555	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FX988_RS00585	COG1028	Short-chain dehydrogenase reductase Sdr
FX988_RS00630	COG1131	(ABC) transporter
FX988_RS00685	COG2205	protein histidine kinase activity
FX988_RS00685	COG2202	Pas domain
FX988_RS00695	COG3901	Regulator of nitric oxide reductase transcription
FX988_RS00695	COG0348	domain, Protein
FX988_RS00705	COG0702	epimerase
FX988_RS00725	COG0017	Asparaginyl-tRNA synthetase
FX988_RS00745	COG1522	sequence-specific DNA binding
FX988_RS00750	COG1757	Na H antiporter
FX988_RS00765	COG1785	Belongs to the alkaline phosphatase family
FX988_RS00770	COG1785	Belongs to the alkaline phosphatase family
FX988_RS00775	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FX988_RS00780	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FX988_RS00785	COG0215	cysteine-tRNA ligase activity
FX988_RS00795	COG0741	lytic transglycosylase activity
FX988_RS00795	COG1388	LysM domain
FX988_RS00805	COG2226	methyltransferase
FX988_RS00810	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FX988_RS00810	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FX988_RS00815	COG0489	protein tyrosine kinase activity
FX988_RS00820	COG0717	Belongs to the dCTP deaminase family
FX988_RS00825	COG2207	Transcriptional regulator
FX988_RS00885	COG1484	DNA-dependent DNA replication
FX988_RS00990	COG3119	arylsulfatase activity
FX988_RS01030	COG3119	arylsulfatase activity
FX988_RS01045	COG1012	belongs to the aldehyde dehydrogenase family
FX988_RS01050	COG1028	Short-chain dehydrogenase reductase Sdr
FX988_RS01060	COG4948	Mandelate Racemase Muconate Lactonizing
FX988_RS01085	COG2205	protein histidine kinase activity
FX988_RS01085	COG0784	Response regulator, receiver
FX988_RS01110	COG0534	Mate efflux family protein
FX988_RS01115	COG0303	'Molybdopterin
FX988_RS01130	COG2146	nitrite reductase [NAD(P)H] activity
FX988_RS01130	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FX988_RS01135	COG2146	nitrite reductase [NAD(P)H] activity
FX988_RS01140	COG0243	molybdopterin cofactor binding
FX988_RS01150	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FX988_RS01155	COG2197	response regulator
FX988_RS01160	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FX988_RS01160	COG1116	anion transmembrane transporter activity
FX988_RS01165	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
FX988_RS01180	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FX988_RS01190	COG5001	Diguanylate cyclase
FX988_RS01190	COG3706	GGDEF domain
FX988_RS01190	COG4251	negative regulation of phosphorylation
FX988_RS01190	COG2203	Gaf domain
FX988_RS01210	COG1262	PFAM Formylglycine-generating sulfatase enzyme
FX988_RS01215	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
FX988_RS01225	COG2808	Putative FMN-binding domain
FX988_RS01235	COG0402	S-adenosylhomocysteine deaminase activity
FX988_RS01255	COG1529	Aldehyde oxidase and xanthine dehydrogenase
FX988_RS01265	COG1309	transcriptional regulator
FX988_RS01275	COG2252	PERMEase
FX988_RS01280	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FX988_RS01285	COG2223	nitrite transmembrane transporter activity
FX988_RS01290	COG2815	serine threonine protein kinase
FX988_RS01290	COG0515	serine threonine protein kinase
FX988_RS01295	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FX988_RS01295	COG1116	anion transmembrane transporter activity
FX988_RS01305	COG1116	anion transmembrane transporter activity
FX988_RS01330	COG2119	membrane
FX988_RS01345	COG0577	efflux transmembrane transporter activity
FX988_RS01345	COG1136	(ABC) transporter
FX988_RS01350	COG1136	(ABC) transporter
FX988_RS01355	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FX988_RS01380	COG0446	pyridine nucleotide-disulphide oxidoreductase
FX988_RS01380	COG1902	pentaerythritol trinitrate reductase activity
FX988_RS01385	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FX988_RS01405	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FX988_RS01410	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FX988_RS01415	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FX988_RS01420	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FX988_RS01435	COG3275	phosphorelay sensor kinase activity
FX988_RS01440	COG3279	Response regulator of the LytR AlgR family
FX988_RS01450	COG2850	peptidyl-arginine hydroxylation
FX988_RS01460	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FX988_RS01465	COG2915	High frequency lysogenization protein hflD homolog
FX988_RS01470	COG0482	sulfurtransferase activity
FX988_RS01475	COG1187	pseudouridine synthase activity
FX988_RS01485	COG1278	Cold shock
FX988_RS01490	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
FX988_RS01495	COG0542	response to heat
FX988_RS01500	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FX988_RS01505	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
FX988_RS01510	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
FX988_RS01515	COG0492	ferredoxin-NADP+ reductase activity
FX988_RS01520	COG3092	negative regulation of chromosome organization
FX988_RS01525	COG3091	SprT-like family
FX988_RS01530	COG0616	signal peptide processing
FX988_RS01540	COG0328	RNA-DNA hybrid ribonuclease activity
FX988_RS01545	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FX988_RS01570	COG1253	flavin adenine dinucleotide binding
FX988_RS01575	COG1136	(ABC) transporter
FX988_RS01580	COG4591	ABC-type transport system involved in lipoprotein release permease component
FX988_RS01585	COG1301	dicarboxylic acid transport
FX988_RS01595	COG3724	N-succinylarginine dihydrolase activity
FX988_RS01600	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FX988_RS01605	COG3122	Protein conserved in bacteria
FX988_RS01645	COG2819	hydrolase of the alpha beta superfamily
FX988_RS01650	COG2207	Transcriptional regulator
FX988_RS01655	COG2807	transmembrane transport
FX988_RS01660	COG1012	belongs to the aldehyde dehydrogenase family
FX988_RS01675	COG1028	Short-chain dehydrogenase reductase Sdr
FX988_RS01680	COG0596	Alpha beta hydrolase
FX988_RS01685	COG1250	3-hydroxyacyl-CoA dehydrogenase
FX988_RS01685	COG1024	Enoyl-CoA hydratase
FX988_RS01690	COG0183	Belongs to the thiolase family
FX988_RS01695	COG1960	acyl-CoA dehydrogenase activity
FX988_RS01700	COG0596	Alpha beta hydrolase
FX988_RS01705	COG3706	GGDEF domain
FX988_RS01730	COG2233	PERMEase
FX988_RS01735	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FX988_RS01740	COG2897	thiosulfate sulfurtransferase activity
FX988_RS01755	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
FX988_RS01755	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
FX988_RS01755	COG0506	proline dehydrogenase activity
FX988_RS01765	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FX988_RS01770	COG0505	Belongs to the CarA family
FX988_RS01775	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FX988_RS01780	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FX988_RS01795	COG0815	Transfers the fatty acyl group on membrane lipoproteins
FX988_RS01800	COG4535	Mg2 and Co2 transporter CorC
FX988_RS01805	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FX988_RS01810	COG1702	phosphate starvation-inducible protein PhoH
FX988_RS01815	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FX988_RS01830	COG0583	DNA-binding transcription factor activity
FX988_RS01840	COG2363	Small membrane protein
FX988_RS01845	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
FX988_RS01850	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
FX988_RS01855	COG0033	Phosphoglucomutase
FX988_RS01860	COG0058	SHG alpha-glucan phosphorylase activity
FX988_RS01870	COG2988	succinylglutamate desuccinylase activity
FX988_RS01875	COG0393	Putative heavy-metal-binding
FX988_RS01885	COG1876	peptidase activity
FX988_RS01890	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FX988_RS01895	COG1393	Belongs to the ArsC family
FX988_RS01910	COG0745	RESPONSE REGULATOR receiver
FX988_RS01910	COG3706	GGDEF domain
FX988_RS01930	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FX988_RS01935	COG1028	Short-chain dehydrogenase reductase Sdr
FX988_RS01940	COG2267	carboxylic ester hydrolase activity
FX988_RS01945	COG0616	signal peptide processing
FX988_RS01960	COG0415	Belongs to the DNA photolyase family
FX988_RS01965	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FX988_RS01970	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FX988_RS01975	COG0386	Belongs to the glutathione peroxidase family
FX988_RS01980	COG2084	Dehydrogenase
FX988_RS01995	COG2925	Exonuclease
FX988_RS02005	COG1643	Atp-dependent helicase
FX988_RS02015	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FX988_RS02020	COG0604	alcohol dehydrogenase
FX988_RS02020	COG3321	synthase
FX988_RS02040	COG1215	transferase activity, transferring glycosyl groups
FX988_RS02045	COG3769	mannosylglycerate metabolic process
FX988_RS02055	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FX988_RS02060	COG0746	molybdenum cofactor guanylyltransferase activity
FX988_RS02065	COG0521	Mo-molybdopterin cofactor biosynthetic process
FX988_RS02070	COG0315	cyclic pyranopterin monophosphate synthase activity
FX988_RS02075	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
FX988_RS02100	COG0735	belongs to the Fur family
FX988_RS02105	COG0716	FMN binding
FX988_RS02115	COG0596	Alpha beta hydrolase
FX988_RS02145	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FX988_RS02150	COG4977	sequence-specific DNA binding
FX988_RS02155	COG1960	acyl-CoA dehydrogenase activity
FX988_RS02160	COG2130	NADP-dependent
FX988_RS02170	COG1028	Short-chain dehydrogenase reductase Sdr
FX988_RS02175	COG3784	Protein of unknown function (DUF1318)
FX988_RS02185	COG2911	Protein conserved in bacteria
FX988_RS02190	COG0513	Belongs to the DEAD box helicase family
FX988_RS02195	COG1530	ribonuclease E activity
FX988_RS02200	COG0564	pseudouridine synthase activity
FX988_RS02210	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
FX988_RS02225	COG0424	maF-like protein
FX988_RS02230	COG1399	metal-binding, possibly nucleic acid-binding protein
FX988_RS02235	COG0333	Belongs to the bacterial ribosomal protein bL32 family
FX988_RS02240	COG0416	fatty acid biosynthetic process
FX988_RS02245	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FX988_RS02250	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
FX988_RS02255	COG1028	Short-chain dehydrogenase reductase Sdr
FX988_RS02260	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FX988_RS02265	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FX988_RS02275	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FX988_RS02290	COG0084	hydrolase, TatD family'
FX988_RS02305	COG4993	Dehydrogenase
FX988_RS02315	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
FX988_RS02325	COG0531	amino acid
FX988_RS02340	COG0640	Transcriptional regulator
FX988_RS02345	COG0784	Response regulator, receiver
FX988_RS02345	COG2205	protein histidine kinase activity
FX988_RS02345	COG5002	protein histidine kinase activity
FX988_RS02350	COG0589	response to stress
FX988_RS02355	COG4191	Histidine kinase
FX988_RS02360	COG4566	intracellular signal transduction
FX988_RS02365	COG4566	intracellular signal transduction
FX988_RS02375	COG2217	Heavy metal translocating P-type atpase
FX988_RS02385	COG0745	RESPONSE REGULATOR receiver
FX988_RS02385	COG3706	GGDEF domain
FX988_RS02390	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FX988_RS02410	COG2205	protein histidine kinase activity
FX988_RS02410	COG3437	response regulator, receiver
FX988_RS02410	COG3850	Histidine kinase
FX988_RS02410	COG4999	Histidine kinase
FX988_RS02455	COG2193	ferroxidase activity
FX988_RS02465	COG3278	Belongs to the heme-copper respiratory oxidase family
FX988_RS02480	COG2010	Cytochrome c
FX988_RS02490	COG2217	Heavy metal translocating P-type atpase
FX988_RS02510	COG0037	tRNA processing
FX988_RS02515	COG1752	Esterase of the alpha-beta hydrolase superfamily
FX988_RS02530	COG2992	FlgJ-related protein
FX988_RS02540	COG1280	lysine exporter protein (LysE YggA)
FX988_RS02560	COG0154	amidase activity
FX988_RS02570	COG0730	response to heat
FX988_RS02575	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
FX988_RS02590	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FX988_RS02595	COG2066	Belongs to the glutaminase family
FX988_RS02605	COG1119	ATPase activity
FX988_RS02620	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
FX988_RS02630	COG1946	Acyl-CoA thioesterase
FX988_RS02635	COG0515	serine threonine protein kinase
FX988_RS02640	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
FX988_RS02650	COG0022	dehydrogenase e1 component
FX988_RS02665	COG0436	Aminotransferase
FX988_RS02670	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
FX988_RS02675	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FX988_RS02685	COG0232	Belongs to the dGTPase family. Type 2 subfamily
FX988_RS02705	COG3012	SEC-C Motif Domain Protein
FX988_RS02715	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FX988_RS02720	COG3130	regulation of translation
FX988_RS02740	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FX988_RS02740	COG0116	Belongs to the methyltransferase superfamily
FX988_RS02750	COG0167	dihydroorotate dehydrogenase activity
FX988_RS02755	COG2902	Dehydrogenase
FX988_RS02785	COG0308	aminopeptidase N
FX988_RS02795	COG0733	neurotransmitter:sodium symporter activity
FX988_RS02800	COG0793	Belongs to the peptidase S41A family
FX988_RS02805	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
FX988_RS02815	COG1956	GAF domain-containing protein
FX988_RS02825	COG0484	heat shock protein binding
FX988_RS02830	COG0443	Heat shock 70 kDa protein
FX988_RS02835	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FX988_RS02860	COG2610	gluconate transmembrane transporter activity
FX988_RS02865	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FX988_RS02875	COG1028	Short-chain dehydrogenase reductase Sdr
FX988_RS02900	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
FX988_RS02925	COG3171	Protein conserved in bacteria
FX988_RS02955	COG0625	glutathione transferase activity
FX988_RS03020	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FX988_RS03025	COG0352	thiamine-phosphate diphosphorylase activity
FX988_RS03030	COG2022	thiamine diphosphate biosynthetic process
FX988_RS03045	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
FX988_RS03065	COG2814	Major facilitator Superfamily
FX988_RS03075	COG0840	transmembrane signaling receptor activity
FX988_RS03105	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FX988_RS03120	COG0667	Aldo Keto reductase
FX988_RS03130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FX988_RS03135	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FX988_RS03140	COG0243	molybdopterin cofactor binding
FX988_RS03145	COG3813	Protein conserved in bacteria
FX988_RS03155	COG1136	(ABC) transporter
FX988_RS03165	COG1136	(ABC) transporter
FX988_RS03165	COG0577	efflux transmembrane transporter activity
FX988_RS03175	COG2814	Major facilitator Superfamily
FX988_RS03255	COG0840	transmembrane signaling receptor activity
FX988_RS03260	COG3437	response regulator, receiver
FX988_RS03265	COG0784	Response regulator, receiver
FX988_RS03265	COG5002	protein histidine kinase activity
FX988_RS03265	COG2198	Histidine kinase
FX988_RS03275	COG0745	RESPONSE REGULATOR receiver
FX988_RS03280	COG2205	protein histidine kinase activity
FX988_RS03295	COG0667	Aldo Keto reductase
FX988_RS03305	COG3264	Mechanosensitive ion channel
FX988_RS03305	COG1511	domain protein
FX988_RS03310	COG4206	TonB-dependent receptor
FX988_RS03350	COG0179	Fumarylacetoacetate (FAA) hydrolase
FX988_RS03365	COG2610	gluconate transmembrane transporter activity
FX988_RS03370	COG0251	oxidation-reduction process
FX988_RS03375	COG0210	DNA helicase
FX988_RS03390	COG2860	membrane
FX988_RS03395	COG3128	pkhd-type hydroxylase
FX988_RS03405	COG4774	siderophore transport
FX988_RS03415	COG0848	biopolymer transport protein
FX988_RS03425	COG0811	peptide transport
FX988_RS03440	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
FX988_RS03445	COG5507	3-demethylubiquinone-9 3-methyltransferase
FX988_RS03485	COG1609	Transcriptional regulator
FX988_RS03500	COG0583	DNA-binding transcription factor activity
FX988_RS03580	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FX988_RS03610	COG1280	lysine exporter protein (LysE YggA)
FX988_RS03650	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
FX988_RS03690	COG0745	RESPONSE REGULATOR receiver
FX988_RS03710	COG2124	cytochrome p450
FX988_RS03735	COG3706	GGDEF domain
FX988_RS03745	COG0583	DNA-binding transcription factor activity
FX988_RS03790	COG1250	3-hydroxyacyl-CoA dehydrogenase
FX988_RS03795	COG3246	L-lysine catabolic process to acetate
FX988_RS03820	COG0564	pseudouridine synthase activity
FX988_RS03825	COG0477	Major facilitator Superfamily
FX988_RS03830	COG0513	Belongs to the DEAD box helicase family
FX988_RS03835	COG4771	TonB-dependent receptor
FX988_RS03860	COG1418	mRNA catabolic process
FX988_RS03870	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FX988_RS03875	COG1501	Belongs to the glycosyl hydrolase 31 family
FX988_RS03880	COG2819	hydrolase of the alpha beta superfamily
FX988_RS03910	COG0789	Transcriptional regulator
FX988_RS03960	COG0322	excinuclease ABC activity
FX988_RS03965	COG2197	response regulator
FX988_RS03985	COG0670	Belongs to the BI1 family
FX988_RS03990	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
FX988_RS03995	COG2923	Belongs to the DsrF TusC family
FX988_RS04005	COG2920	part of a sulfur-relay system
FX988_RS04010	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FX988_RS04015	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FX988_RS04020	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FX988_RS04025	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
FX988_RS04030	COG0531	amino acid
FX988_RS04030	COG1674	ftsk spoiiie
FX988_RS04040	COG0686	Belongs to the AlaDH PNT family
FX988_RS04045	COG0284	orotidine-5'-phosphate decarboxylase activity
FX988_RS04050	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
FX988_RS04060	COG0776	regulation of translation
FX988_RS04065	COG0539	negative regulation of cytoplasmic translation
FX988_RS04070	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FX988_RS04075	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FX988_RS04090	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FX988_RS04100	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FX988_RS04110	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FX988_RS04115	COG0367	asparagine synthase
FX988_RS04120	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FX988_RS04125	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
FX988_RS04130	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FX988_RS04140	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FX988_RS04150	COG4783	chaperone-mediated protein folding
FX988_RS04160	COG1393	Belongs to the ArsC family
FX988_RS04185	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FX988_RS04190	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FX988_RS04200	COG1960	acyl-CoA dehydrogenase activity
FX988_RS04205	COG0776	regulation of translation
FX988_RS04210	COG0072	phenylalanine-tRNA ligase activity
FX988_RS04210	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FX988_RS04215	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FX988_RS04220	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FX988_RS04225	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FX988_RS04265	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FX988_RS04285	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
FX988_RS04300	COG0835	chemotaxis
FX988_RS04305	COG2198	Histidine kinase
FX988_RS04305	COG0643	Histidine kinase
FX988_RS04310	COG0745	RESPONSE REGULATOR receiver
FX988_RS04325	COG0840	transmembrane signaling receptor activity
FX988_RS04360	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
FX988_RS04375	COG3604	Transcriptional regulator
FX988_RS04380	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FX988_RS04390	COG3214	Protein conserved in bacteria
FX988_RS04410	COG3237	CsbD-like
FX988_RS04415	COG2315	Protein conserved in bacteria
FX988_RS04425	COG4591	ABC-type transport system involved in lipoprotein release permease component
FX988_RS04435	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FX988_RS04465	COG0583	DNA-binding transcription factor activity
FX988_RS04475	COG0471	metal ion transport
FX988_RS04480	COG1472	Belongs to the glycosyl hydrolase 3 family
FX988_RS04485	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FX988_RS04490	COG0497	DNA recombination
FX988_RS04495	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FX988_RS04500	COG0488	(ABC) transporter
FX988_RS04520	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
FX988_RS04535	COG1028	Short-chain dehydrogenase reductase Sdr
FX988_RS04570	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FX988_RS04575	COG2995	paraquat-inducible protein a
FX988_RS04580	COG3008	intermembrane lipid transfer
FX988_RS04580	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FX988_RS04590	COG3706	GGDEF domain
FX988_RS04595	COG5265	(ABC) transporter
FX988_RS04600	COG3530	Putative quorum-sensing-regulated virulence factor
FX988_RS04615	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FX988_RS04620	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FX988_RS04625	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FX988_RS04630	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FX988_RS04635	COG0195	Participates in both transcription termination and antitermination
FX988_RS04640	COG0779	Required for maturation of 30S ribosomal subunits
FX988_RS04655	COG4771	TonB-dependent receptor
FX988_RS04670	COG1960	acyl-CoA dehydrogenase activity
FX988_RS04690	COG4948	Mandelate Racemase Muconate Lactonizing
FX988_RS04700	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FX988_RS04710	COG2203	Gaf domain
FX988_RS04710	COG2199	diguanylate cyclase activity
FX988_RS04720	COG2234	aminopeptidase activity
FX988_RS04730	COG1741	Belongs to the pirin family
FX988_RS04735	COG0583	DNA-binding transcription factor activity
FX988_RS04740	COG2130	NADP-dependent
FX988_RS04745	COG0583	DNA-binding transcription factor activity
FX988_RS04760	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FX988_RS04765	COG4137	Cytochrome C assembly protein
FX988_RS04770	COG4536	flavin adenine dinucleotide binding
FX988_RS04780	COG2062	phosphohistidine phosphatase, SixA
FX988_RS04785	COG0612	Peptidase, M16
FX988_RS04795	COG1250	3-hydroxyacyl-CoA dehydrogenase
FX988_RS04795	COG1024	Enoyl-CoA hydratase
FX988_RS04800	COG0183	Belongs to the thiolase family
FX988_RS04805	COG0714	Associated with various cellular activities
FX988_RS04825	COG2304	oxidoreductase activity
FX988_RS04850	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FX988_RS04855	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
FX988_RS04860	COG0175	sulfate reduction
FX988_RS04865	COG0529	Catalyzes the synthesis of activated sulfate
FX988_RS04870	COG1218	3'(2'),5'-bisphosphate nucleotidase
FX988_RS04875	COG2895	sulfate adenylyltransferase (ATP) activity
FX988_RS04880	COG3273	potassium ion transport
FX988_RS04880	COG0471	metal ion transport
FX988_RS04885	COG1187	pseudouridine synthase activity
FX988_RS04895	COG3139	Protein of unknown function (DUF1315)
FX988_RS04905	COG1115	amino acid carrier protein
FX988_RS04910	COG2866	Carboxypeptidase
FX988_RS04925	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FX988_RS04935	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FX988_RS04940	COG1640	4-alpha-glucanotransferase
FX988_RS04950	COG0676	glucose-6-phosphate 1-epimerase activity
FX988_RS04955	COG1185	polyribonucleotide nucleotidyltransferase activity
FX988_RS04965	COG0564	pseudouridine synthase activity
FX988_RS04970	COG1322	Protein conserved in bacteria
FX988_RS04990	COG1760	l-serine dehydratase
FX988_RS04995	COG0583	DNA-binding transcription factor activity
FX988_RS05010	COG0583	DNA-binding transcription factor activity
FX988_RS05015	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
FX988_RS05025	COG0513	Belongs to the DEAD box helicase family
FX988_RS05030	COG0778	Nitroreductase
FX988_RS05035	COG2259	Doxx family
FX988_RS05055	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
FX988_RS05060	COG1286	toxin biosynthetic process
FX988_RS05065	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
FX988_RS05070	COG0285	dihydrofolate synthase activity
FX988_RS05075	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FX988_RS05080	COG0101	tRNA pseudouridine synthase activity
FX988_RS05085	COG2204	response regulator
FX988_RS05095	COG2205	protein histidine kinase activity
FX988_RS05110	COG3842	ATPase activity
FX988_RS05115	COG1178	ABC-type Fe3 transport system permease component
FX988_RS05120	COG1840	ABC-type Fe3 transport system, periplasmic component
FX988_RS05130	COG0745	RESPONSE REGULATOR receiver
FX988_RS05140	COG0023	Translation Initiation Factor
FX988_RS05145	COG0745	RESPONSE REGULATOR receiver
FX988_RS05150	COG0077	Prephenate dehydratase
FX988_RS05150	COG1605	Chorismate mutase
FX988_RS05160	COG1605	Chorismate mutase
FX988_RS05160	COG0287	Prephenate dehydrogenase
FX988_RS05165	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FX988_RS05170	COG0339	signal peptide processing
FX988_RS05180	COG0110	maltose O-acetyltransferase activity
FX988_RS05185	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
FX988_RS05190	COG0789	Transcriptional regulator
FX988_RS05200	COG0335	large ribosomal subunit rRNA binding
FX988_RS05205	COG0336	Belongs to the RNA methyltransferase TrmD family
FX988_RS05210	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FX988_RS05215	COG0228	four-way junction DNA binding
FX988_RS05220	COG3842	ATPase activity
FX988_RS05230	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FX988_RS05235	COG0149	triose-phosphate isomerase activity
FX988_RS05240	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FX988_RS05245	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FX988_RS05250	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FX988_RS05255	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
FX988_RS05260	COG1534	Rna-binding protein
FX988_RS05265	COG1047	Peptidyl-prolyl cis-trans
FX988_RS05270	COG1067	ATP-dependent peptidase activity
FX988_RS05280	COG0495	leucyl-tRNA aminoacylation
FX988_RS05295	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FX988_RS05300	COG0799	negative regulation of ribosome biogenesis
FX988_RS05305	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
FX988_RS05310	COG0768	penicillin binding
FX988_RS05315	COG0772	Belongs to the SEDS family
FX988_RS05320	COG2951	lytic endotransglycosylase activity
FX988_RS05325	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FX988_RS05330	COG1686	Belongs to the peptidase S11 family
FX988_RS05335	COG2921	Belongs to the UPF0250 family
FX988_RS05340	COG0321	lipoyl(octanoyl) transferase activity
FX988_RS05345	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FX988_RS05365	COG3706	GGDEF domain
FX988_RS05375	COG3123	guanosine phosphorylase activity
FX988_RS05380	COG0412	Dienelactone hydrolase
FX988_RS05390	COG0252	asparaginase activity
FX988_RS05395	COG1278	Cold shock
FX988_RS05405	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FX988_RS05410	COG2890	protein-(glutamine-N5) methyltransferase activity
FX988_RS05415	COG2840	Smr protein MutS2
FX988_RS05440	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FX988_RS05440	COG4191	Histidine kinase
FX988_RS05445	COG2204	response regulator
FX988_RS05475	COG2205	protein histidine kinase activity
FX988_RS05480	COG0745	RESPONSE REGULATOR receiver
FX988_RS05495	COG0500	methyltransferase
FX988_RS05505	COG1595	DNA-templated transcription, initiation
FX988_RS05510	COG3712	iron ion homeostasis
FX988_RS05540	COG1136	(ABC) transporter
FX988_RS05540	COG0577	efflux transmembrane transporter activity
FX988_RS05545	COG0577	efflux transmembrane transporter activity
FX988_RS05545	COG1136	(ABC) transporter
FX988_RS05555	COG3608	succinylglutamate desuccinylase aspartoacylase
FX988_RS05560	COG0189	ligase activity
FX988_RS05575	COG1505	serine-type exopeptidase activity
FX988_RS05590	COG0339	signal peptide processing
FX988_RS05595	COG1473	amidohydrolase
FX988_RS05600	COG0583	DNA-binding transcription factor activity
FX988_RS05610	COG4948	Mandelate Racemase Muconate Lactonizing
FX988_RS05650	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
FX988_RS05655	COG2186	Transcriptional regulator
FX988_RS05660	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FX988_RS05665	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
FX988_RS05685	COG3046	protein related to deoxyribodipyrimidine photolyase
FX988_RS05695	COG2983	Belongs to the UPF0260 family
FX988_RS05705	COG0179	Fumarylacetoacetate (FAA) hydrolase
FX988_RS05710	COG2951	lytic endotransglycosylase activity
FX988_RS05715	COG3100	YcgL domain-containing protein
FX988_RS05720	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
FX988_RS05725	COG0318	PFAM AMP-dependent synthetase and ligase
FX988_RS05750	COG1199	ATP-dependent helicase activity
FX988_RS05755	COG0366	Alpha amylase catalytic
FX988_RS05765	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
FX988_RS05815	COG1028	Short-chain dehydrogenase reductase Sdr
FX988_RS05820	COG0024	Methionine aminopeptidase
FX988_RS05900	COG1187	pseudouridine synthase activity
FX988_RS05905	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
FX988_RS05915	COG0009	L-threonylcarbamoyladenylate synthase
FX988_RS05920	COG0613	PHP domain protein
FX988_RS05925	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FX988_RS05930	COG0512	Glutamine amidotransferase of anthranilate synthase
FX988_RS05935	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FX988_RS05940	COG0134	indole-3-glycerol-phosphate synthase activity
FX988_RS05940	COG0135	phosphoribosylanthranilate isomerase activity
FX988_RS05945	COG0133	tryptophan synthase activity
FX988_RS05955	COG2350	Protein conserved in bacteria
FX988_RS05970	COG0745	RESPONSE REGULATOR receiver
FX988_RS05980	COG0668	transmembrane transport
FX988_RS05985	COG0754	glutathionylspermidine amidase activity
FX988_RS06000	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
FX988_RS06020	COG1234	tRNA 3'-trailer cleavage
FX988_RS06030	COG4771	TonB-dependent receptor
FX988_RS06035	COG0737	Belongs to the 5'-nucleotidase family
FX988_RS06050	COG4206	TonB-dependent receptor
FX988_RS06080	COG2188	Transcriptional regulator
FX988_RS06085	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
FX988_RS06090	COG4988	ABC transporter
FX988_RS06095	COG4890	Cyd operon protein YbgT
FX988_RS06100	COG1294	oxidase, subunit
FX988_RS06110	COG1280	lysine exporter protein (LysE YggA)
FX988_RS06120	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
FX988_RS06120	COG0456	acetyltransferase
FX988_RS06130	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
FX988_RS06140	COG0625	glutathione transferase activity
FX988_RS06145	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FX988_RS06155	COG3781	membrane
FX988_RS06160	COG2031	fatty acid transporter
FX988_RS06170	COG1309	transcriptional regulator
FX988_RS06180	COG0583	DNA-binding transcription factor activity
FX988_RS06200	COG0583	DNA-binding transcription factor activity
FX988_RS06210	COG0069	glutamate synthase activity
FX988_RS06240	COG4302	ethanolamine ammonia-lyase activity
FX988_RS06245	COG4303	Ethanolamine ammonia lyase large subunit
FX988_RS06250	COG1064	alcohol dehydrogenase
FX988_RS06255	COG1902	pentaerythritol trinitrate reductase activity
FX988_RS06260	COG2203	Gaf domain
FX988_RS06260	COG5001	Diguanylate cyclase
FX988_RS06260	COG4251	negative regulation of phosphorylation
FX988_RS06260	COG3706	GGDEF domain
FX988_RS06265	COG2814	Major facilitator Superfamily
FX988_RS06270	COG2828	Protein conserved in bacteria
FX988_RS06275	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
FX988_RS06280	COG0372	Belongs to the citrate synthase family
FX988_RS06285	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
FX988_RS06290	COG1802	Transcriptional regulator
FX988_RS06305	COG3119	arylsulfatase activity
FX988_RS06325	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
FX988_RS06345	COG2076	Multidrug Resistance protein
FX988_RS06350	COG0346	lactoylglutathione lyase activity
FX988_RS06355	COG0584	glycerophosphoryl diester phosphodiesterase
FX988_RS06365	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FX988_RS06370	COG0450	alkyl hydroperoxide reductase
FX988_RS06375	COG2906	2 iron, 2 sulfur cluster binding
FX988_RS06380	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
FX988_RS06390	COG2766	serine protein kinase
FX988_RS06395	COG2718	Belongs to the UPF0229 family
FX988_RS06400	COG2719	SpoVR family
FX988_RS06405	COG4628	conserved protein (DUF2132)
FX988_RS06410	COG1451	nucleotide metabolic process
FX988_RS06415	COG3112	Uncharacterised protein family (UPF0231)
FX988_RS06450	COG1230	cation diffusion facilitator family transporter
FX988_RS06455	COG0789	Transcriptional regulator
FX988_RS06490	COG4989	oxidoreductase activity
FX988_RS06495	COG0583	DNA-binding transcription factor activity
FX988_RS06500	COG0446	pyridine nucleotide-disulphide oxidoreductase
FX988_RS06500	COG1902	pentaerythritol trinitrate reductase activity
FX988_RS06505	COG1024	Enoyl-CoA hydratase
FX988_RS06515	COG0318	PFAM AMP-dependent synthetase and ligase
FX988_RS06535	COG0612	Peptidase, M16
FX988_RS06545	COG0564	pseudouridine synthase activity
FX988_RS06550	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FX988_RS06555	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FX988_RS06565	COG0018	arginyl-trna synthetase
FX988_RS06570	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
FX988_RS06590	COG0300	oxidoreductase activity
FX988_RS06605	COG1309	transcriptional regulator
FX988_RS06625	COG0583	DNA-binding transcription factor activity
FX988_RS06660	COG0456	acetyltransferase
FX988_RS06705	COG1444	tRNA N-acetyltransferase activity
FX988_RS06745	COG1183	phosphatidylcholine synthase activity
FX988_RS06760	COG0542	response to heat
FX988_RS06770	COG0564	pseudouridine synthase activity
FX988_RS06775	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FX988_RS06785	COG1595	DNA-templated transcription, initiation
FX988_RS06800	COG4221	oxidoreductase activity
FX988_RS06815	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FX988_RS06835	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
FX988_RS06840	COG1722	exodeoxyribonuclease VII activity
FX988_RS06845	COG0142	geranyltranstransferase activity
FX988_RS06850	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FX988_RS06855	COG1671	Belongs to the UPF0178 family
FX988_RS06860	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
FX988_RS06870	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FX988_RS06875	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
FX988_RS06890	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FX988_RS06890	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FX988_RS06895	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FX988_RS06915	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FX988_RS06930	COG0488	(ABC) transporter
FX988_RS06935	COG5002	protein histidine kinase activity
FX988_RS06940	COG0109	protoheme IX farnesyltransferase activity
FX988_RS06960	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FX988_RS07025	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
FX988_RS07035	COG0560	Phosphoserine phosphatase
FX988_RS07040	COG1720	tRNA m6t6A37 methyltransferase activity
FX988_RS07045	COG0442	prolyl-tRNA aminoacylation
FX988_RS07065	COG4807	Protein conserved in bacteria
FX988_RS07090	COG0583	DNA-binding transcription factor activity
FX988_RS07100	COG0037	tRNA processing
FX988_RS07105	COG0825	malonyl-CoA metabolic process
FX988_RS07115	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FX988_RS07130	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FX988_RS07135	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FX988_RS07155	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
FX988_RS07160	COG0575	Belongs to the CDS family
FX988_RS07165	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FX988_RS07170	COG0233	cytoplasmic translational termination
FX988_RS07175	COG0528	UMP kinase activity
FX988_RS07180	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FX988_RS07185	COG0052	Belongs to the universal ribosomal protein uS2 family
FX988_RS07190	COG0024	Methionine aminopeptidase
FX988_RS07195	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
FX988_RS07220	COG0443	Heat shock 70 kDa protein
FX988_RS07225	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
FX988_RS07230	COG0316	Belongs to the HesB IscA family
FX988_RS07235	COG0822	iron-sulfur transferase activity
FX988_RS07240	COG1104	cysteine desulfurase activity
FX988_RS07245	COG1959	2 iron, 2 sulfur cluster binding
FX988_RS07250	COG1045	serine acetyltransferase
FX988_RS07255	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
FX988_RS07265	COG0346	lactoylglutathione lyase activity
FX988_RS07270	COG0483	inositol monophosphate 1-phosphatase activity
FX988_RS07275	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FX988_RS07280	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FX988_RS07285	COG1862	Preprotein translocase
FX988_RS07290	COG0343	queuine tRNA-ribosyltransferase activity
FX988_RS07295	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
FX988_RS07310	COG1842	Phage shock protein A
FX988_RS07335	COG0754	glutathionylspermidine amidase activity
FX988_RS07340	COG0705	Rhomboid family
FX988_RS07350	COG1785	Belongs to the alkaline phosphatase family
FX988_RS07365	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
FX988_RS07400	COG1434	Gram-negative-bacterium-type cell wall biogenesis
FX988_RS07455	COG0367	asparagine synthase
FX988_RS07460	COG0438	transferase activity, transferring glycosyl groups
FX988_RS07470	COG0438	transferase activity, transferring glycosyl groups
FX988_RS07495	COG2244	polysaccharide biosynthetic process
FX988_RS07580	COG0489	protein tyrosine kinase activity
FX988_RS07590	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FX988_RS07590	COG0475	glutathione-regulated potassium exporter activity
FX988_RS07600	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FX988_RS07610	COG0123	including yeast histone deacetylase and acetoin utilization protein
FX988_RS07615	COG3132	Protein of unknown function, DUF480
FX988_RS07645	COG2207	Transcriptional regulator
FX988_RS07645	COG1917	Cupin 2, conserved barrel domain protein
FX988_RS07650	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FX988_RS07670	COG0189	ligase activity
FX988_RS07680	COG3275	phosphorelay sensor kinase activity
FX988_RS07685	COG3279	Response regulator of the LytR AlgR family
FX988_RS07730	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FX988_RS07735	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
FX988_RS07745	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
FX988_RS07755	COG0463	Glycosyl transferase, family 2
FX988_RS07760	COG0745	RESPONSE REGULATOR receiver
FX988_RS07775	COG4774	siderophore transport
FX988_RS07780	COG1120	ATPase activity
FX988_RS07785	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FX988_RS07790	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
FX988_RS07795	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
FX988_RS07810	COG1492	cobalamin metabolic process
FX988_RS07815	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
FX988_RS07820	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FX988_RS07825	COG0406	alpha-ribazole phosphatase activity
FX988_RS07830	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
FX988_RS07845	COG1250	3-hydroxyacyl-CoA dehydrogenase
FX988_RS07875	COG0275	rRNA processing
FX988_RS07880	COG3119	arylsulfatase activity
FX988_RS07890	COG1024	Enoyl-CoA hydratase
FX988_RS07890	COG1250	3-hydroxyacyl-CoA dehydrogenase
FX988_RS07895	COG0179	Fumarylacetoacetate (FAA) hydrolase
FX988_RS07900	COG1414	Transcriptional regulator
FX988_RS07920	COG0625	glutathione transferase activity
FX988_RS07925	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FX988_RS07925	COG1017	nitric oxide dioxygenase activity
FX988_RS07940	COG2942	2-epimerase
FX988_RS07945	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
FX988_RS07955	COG1609	Transcriptional regulator
FX988_RS07965	COG3119	arylsulfatase activity
FX988_RS07980	COG4124	Belongs to the glycosyl hydrolase 26 family
FX988_RS07985	COG4206	TonB-dependent receptor
FX988_RS07990	COG1966	Carbon starvation protein
FX988_RS08015	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FX988_RS08065	COG1216	Glycosyl transferase, family 2
FX988_RS08065	COG0463	Glycosyl transferase, family 2
FX988_RS08075	COG1045	serine acetyltransferase
FX988_RS08100	COG0438	transferase activity, transferring glycosyl groups
FX988_RS08160	COG4464	protein tyrosine phosphatase activity
FX988_RS08195	COG3634	alkyl hydroperoxide reductase activity
FX988_RS08200	COG0450	alkyl hydroperoxide reductase
FX988_RS08210	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
FX988_RS08215	COG0848	biopolymer transport protein
FX988_RS08220	COG0811	peptide transport
FX988_RS08225	COG0811	peptide transport
FX988_RS08240	COG0672	)-iron permease
FX988_RS08265	COG5002	protein histidine kinase activity
FX988_RS08270	COG0745	RESPONSE REGULATOR receiver
FX988_RS08275	COG4191	Histidine kinase
FX988_RS08275	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FX988_RS08280	COG2974	May be involved in recombination
FX988_RS08295	COG5001	Diguanylate cyclase
FX988_RS08295	COG3300	MHYT domain
FX988_RS08300	COG0537	adenosine 5'-monophosphoramidase activity
FX988_RS08305	COG1968	undecaprenyl-diphosphatase activity
FX988_RS08315	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FX988_RS08320	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
FX988_RS08330	COG0828	Belongs to the bacterial ribosomal protein bS21 family
FX988_RS08335	COG1610	YqeY-like protein
FX988_RS08340	COG0358	DNA primase activity
FX988_RS08345	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FX988_RS08350	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FX988_RS08360	COG2356	endonuclease I
FX988_RS08370	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
FX988_RS08375	COG0204	Acyl-transferase
FX988_RS08380	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
FX988_RS08385	COG2204	response regulator
FX988_RS08390	COG3852	Histidine kinase
FX988_RS08400	COG0174	glutamine synthetase
FX988_RS08415	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FX988_RS08420	COG2986	histidine ammonia-lyase
FX988_RS08430	COG2188	Transcriptional regulator
FX988_RS08435	COG1228	amidohydrolase
FX988_RS08485	COG0203	ribosomal protein L17
FX988_RS08490	COG0202	RNA polymerase activity
FX988_RS08495	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FX988_RS08500	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FX988_RS08505	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FX988_RS08510	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FX988_RS08515	COG0201	protein transport
FX988_RS08520	COG0200	Binds to the 23S rRNA
FX988_RS08525	COG1841	ribosomal large subunit assembly
FX988_RS08530	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FX988_RS08535	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
FX988_RS08540	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FX988_RS08545	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FX988_RS08550	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FX988_RS08560	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FX988_RS08565	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FX988_RS08570	COG1022	Amp-dependent synthetase and ligase
FX988_RS08575	COG0583	DNA-binding transcription factor activity
FX988_RS08590	COG0557	exoribonuclease II activity
FX988_RS08595	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
FX988_RS08610	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
FX988_RS08615	COG2267	carboxylic ester hydrolase activity
FX988_RS08620	COG2205	protein histidine kinase activity
FX988_RS08625	COG0745	RESPONSE REGULATOR receiver
FX988_RS08635	COG1803	Methylglyoxal synthase
FX988_RS08650	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
FX988_RS08660	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FX988_RS08665	COG0137	argininosuccinate synthase activity
FX988_RS08670	COG0165	Argininosuccinate lyase
FX988_RS08675	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
FX988_RS08675	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FX988_RS08690	COG0800	Aldolase
FX988_RS08700	COG0129	dihydroxy-acid dehydratase activity
FX988_RS08705	COG0363	glucosamine-6-phosphate deaminase activity
FX988_RS08710	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FX988_RS08715	COG1737	Transcriptional regulator
FX988_RS08720	COG0469	pyruvate kinase activity
FX988_RS08750	COG2815	serine threonine protein kinase
FX988_RS08750	COG0515	serine threonine protein kinase
FX988_RS08775	COG0121	glutamine amidotransferase
FX988_RS08795	COG1028	Short-chain dehydrogenase reductase Sdr
FX988_RS08805	COG1024	Enoyl-CoA hydratase
FX988_RS08810	COG1960	acyl-CoA dehydrogenase activity
FX988_RS08855	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
FX988_RS08865	COG0850	regulation of cytokinetic process
FX988_RS08900	COG2205	protein histidine kinase activity
FX988_RS08905	COG0745	RESPONSE REGULATOR receiver
FX988_RS08910	COG0625	glutathione transferase activity
FX988_RS08920	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
FX988_RS08945	COG4771	TonB-dependent receptor
FX988_RS08950	COG0583	DNA-binding transcription factor activity
FX988_RS08975	COG0628	permease
FX988_RS09025	COG2186	Transcriptional regulator
FX988_RS09030	COG2814	Major facilitator Superfamily
FX988_RS09035	COG0800	Aldolase
FX988_RS09040	COG3734	2-keto-3-deoxy-galactonokinase
FX988_RS09045	COG4948	Mandelate Racemase Muconate Lactonizing
FX988_RS09050	COG1012	belongs to the aldehyde dehydrogenase family
FX988_RS09055	COG3119	arylsulfatase activity
FX988_RS09060	COG2186	Transcriptional regulator
FX988_RS09070	COG3119	arylsulfatase activity
FX988_RS09075	COG3119	arylsulfatase activity
FX988_RS09140	COG2271	Major facilitator Superfamily
FX988_RS09145	COG4948	Mandelate Racemase Muconate Lactonizing
FX988_RS09150	COG3119	arylsulfatase activity
FX988_RS09165	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FX988_RS09170	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
FX988_RS09185	COG0295	cytidine deaminase activity
FX988_RS09210	COG4771	TonB-dependent receptor
FX988_RS09235	COG0443	Heat shock 70 kDa protein
FX988_RS09250	COG0246	Mannitol dehydrogenase
FX988_RS09265	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FX988_RS09285	COG0697	spore germination
FX988_RS09290	COG2207	Transcriptional regulator
FX988_RS09295	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FX988_RS09305	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FX988_RS09320	COG0457	Tetratricopeptide repeat
FX988_RS09325	COG4771	TonB-dependent receptor
FX988_RS09330	COG0668	transmembrane transport
FX988_RS09340	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
FX988_RS09345	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
FX988_RS09345	COG3264	Mechanosensitive ion channel
FX988_RS09360	COG4251	negative regulation of phosphorylation
FX988_RS09360	COG5001	Diguanylate cyclase
FX988_RS09360	COG2203	Gaf domain
FX988_RS09360	COG3706	GGDEF domain
FX988_RS09400	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FX988_RS09400	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FX988_RS09420	COG1764	response to oxidative stress
FX988_RS09455	COG3447	MASE1 domain protein
FX988_RS09455	COG5001	Diguanylate cyclase
FX988_RS09455	COG5002	protein histidine kinase activity
FX988_RS09465	COG0281	malic enzyme
FX988_RS09470	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
FX988_RS09500	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FX988_RS09505	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FX988_RS09515	COG0338	D12 class N6 adenine-specific DNA methyltransferase
FX988_RS09535	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FX988_RS09540	COG0180	Tryptophanyl-tRNA synthetase
FX988_RS09550	COG1960	acyl-CoA dehydrogenase activity
FX988_RS09565	COG0512	Glutamine amidotransferase of anthranilate synthase
FX988_RS09575	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FX988_RS09585	COG1012	belongs to the aldehyde dehydrogenase family
FX988_RS09595	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
FX988_RS09605	COG2239	Acts as a magnesium transporter
FX988_RS09615	COG1404	Belongs to the peptidase S8 family
FX988_RS09620	COG0004	ammonium transporteR
FX988_RS09625	COG0583	DNA-binding transcription factor activity
FX988_RS09630	COG1960	acyl-CoA dehydrogenase activity
FX988_RS09655	COG0385	Bile acid
FX988_RS09660	COG3135	benzoate transporter
FX988_RS09675	COG1435	thymidine kinase activity
FX988_RS09685	COG0028	Belongs to the TPP enzyme family
FX988_RS09715	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FX988_RS09720	COG0514	ATP-dependent DNA helicase (RecQ)
FX988_RS09730	COG3706	GGDEF domain
FX988_RS09745	COG2267	carboxylic ester hydrolase activity
FX988_RS09760	COG0659	secondary active sulfate transmembrane transporter activity
FX988_RS09765	COG0545	Peptidyl-prolyl cis-trans isomerase
FX988_RS09770	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
FX988_RS09775	COG1739	Uncharacterized protein family UPF0029
FX988_RS09785	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FX988_RS09790	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FX988_RS09795	COG0049	tRNA binding
FX988_RS09800	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FX988_RS09805	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FX988_RS09810	COG0085	RNA polymerase activity
FX988_RS09815	COG0222	ribosome binding
FX988_RS09820	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FX988_RS09825	COG0081	regulation of translation
FX988_RS09830	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FX988_RS09835	COG0250	Participates in transcription elongation, termination and antitermination
FX988_RS09840	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FX988_RS09850	COG1132	(ABC) transporter
FX988_RS09855	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FX988_RS09870	COG0513	Belongs to the DEAD box helicase family
FX988_RS09890	COG0418	dihydroorotase activity
FX988_RS09900	COG2824	Alkylphosphonate utilization operon protein PhnA
FX988_RS09910	COG3040	lipid binding
FX988_RS09925	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FX988_RS09930	COG1660	Displays ATPase and GTPase activities
FX988_RS09935	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FX988_RS09945	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
FX988_RS09950	COG1137	ATPase activity
FX988_RS09965	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
FX988_RS09970	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
FX988_RS09970	COG0517	IMP dehydrogenase activity
FX988_RS09980	COG1127	ABC transporter
FX988_RS09985	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FX988_RS09990	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FX988_RS09995	COG2854	intermembrane phospholipid transfer
FX988_RS10005	COG5007	Belongs to the BolA IbaG family
FX988_RS10010	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FX988_RS10015	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FX988_RS10020	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FX988_RS10030	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
FX988_RS10035	COG0217	transcriptional regulatory protein
FX988_RS10040	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FX988_RS10045	COG0302	gtp cyclohydrolase
FX988_RS10055	COG0038	chloride channel
FX988_RS10065	COG0316	Belongs to the HesB IscA family
FX988_RS10090	COG0039	L-malate dehydrogenase activity
FX988_RS10095	COG1438	arginine binding
FX988_RS10120	COG0572	uridine kinase
FX988_RS10125	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FX988_RS10145	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
FX988_RS10145	COG0517	IMP dehydrogenase activity
FX988_RS10150	COG5001	Diguanylate cyclase
FX988_RS10160	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FX988_RS10170	COG2205	protein histidine kinase activity
FX988_RS10170	COG0784	Response regulator, receiver
FX988_RS10180	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FX988_RS10190	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FX988_RS10210	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FX988_RS10215	COG0739	heme binding
FX988_RS10220	COG1522	sequence-specific DNA binding
FX988_RS10290	COG1522	sequence-specific DNA binding
FX988_RS10310	COG0540	Belongs to the ATCase OTCase family
FX988_RS10315	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FX988_RS10325	COG2837	iron assimilation
FX988_RS10340	COG2205	protein histidine kinase activity
FX988_RS10350	COG0004	ammonium transporteR
FX988_RS10355	COG0347	Belongs to the P(II) protein family
FX988_RS10365	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FX988_RS10370	COG1643	Atp-dependent helicase
FX988_RS10375	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
FX988_RS10380	COG0788	formyltetrahydrofolate deformylase activity
FX988_RS10400	COG2995	paraquat-inducible protein a
FX988_RS10405	COG0753	catalase activity
FX988_RS10430	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FX988_RS10435	COG0255	Belongs to the universal ribosomal protein uL29 family
FX988_RS10440	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FX988_RS10445	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FX988_RS10450	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FX988_RS10455	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FX988_RS10460	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FX988_RS10465	COG0089	rRNA binding
FX988_RS10470	COG0088	Forms part of the polypeptide exit tunnel
FX988_RS10475	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FX988_RS10480	COG0051	transcription antitermination factor activity, RNA binding
FX988_RS10485	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FX988_RS10490	COG1228	amidohydrolase
FX988_RS10495	COG3706	GGDEF domain
FX988_RS10500	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FX988_RS10520	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FX988_RS10525	COG2991	Protein conserved in bacteria
FX988_RS10530	COG1477	protein flavinylation
FX988_RS10535	COG2871	sodium ion transport
FX988_RS10540	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FX988_RS10545	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FX988_RS10550	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FX988_RS10555	COG1805	sodium ion transport
FX988_RS10560	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FX988_RS10565	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FX988_RS10575	COG0271	Belongs to the BolA IbaG family
FX988_RS10585	COG2813	Specifically methylates the guanine in position
FX988_RS10605	COG3706	GGDEF domain
FX988_RS10610	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
FX988_RS10620	COG1509	lysine 2,3-aminomutase activity
FX988_RS10645	COG0187	DNA topoisomerase II activity
FX988_RS10650	COG3150	esterase
FX988_RS10655	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
FX988_RS10660	COG3151	Protein conserved in bacteria
FX988_RS10665	COG0494	nUDIX hydrolase
FX988_RS10670	COG1538	Outer membrane efflux protein
FX988_RS10675	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
FX988_RS10680	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
FX988_RS10690	COG0824	Thioesterase
FX988_RS10695	COG1454	alcohol dehydrogenase
FX988_RS10715	COG0513	Belongs to the DEAD box helicase family
FX988_RS10720	COG1648	precorrin-2 dehydrogenase activity
FX988_RS10720	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FX988_RS10735	COG4771	TonB-dependent receptor
FX988_RS10750	COG1104	cysteine desulfurase activity
FX988_RS10755	COG3483	tryptophan 2,3-dioxygenase activity
FX988_RS10760	COG1522	sequence-specific DNA binding
FX988_RS10770	COG1872	DUF167
FX988_RS10780	COG3284	Transcriptional regulator
FX988_RS10785	COG0022	dehydrogenase e1 component
FX988_RS10790	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
FX988_RS10810	COG0508	dehydrogenase complex catalyzes the overall conversion of
FX988_RS10815	COG0508	dehydrogenase complex catalyzes the overall conversion of
FX988_RS10830	COG2234	aminopeptidase activity
FX988_RS10835	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FX988_RS10845	COG2319	Wd-40 repeat
FX988_RS10845	COG4249	Peptidase C14 caspase catalytic subunit p20
FX988_RS10885	COG5001	Diguanylate cyclase
FX988_RS10885	COG4251	negative regulation of phosphorylation
FX988_RS10885	COG3706	GGDEF domain
FX988_RS10885	COG2203	Gaf domain
FX988_RS10900	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FX988_RS10910	COG4134	Bacterial extracellular solute-binding protein
FX988_RS10915	COG4135	transport system, permease component
FX988_RS10920	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
FX988_RS10925	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FX988_RS10950	COG1607	acyl-coa hydrolase
FX988_RS10960	COG0366	Alpha amylase catalytic
FX988_RS10970	COG2081	HI0933 family
FX988_RS10980	COG0501	Belongs to the peptidase M48B family
FX988_RS10995	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FX988_RS10995	COG0678	peroxiredoxin activity
FX988_RS11000	COG0346	lactoylglutathione lyase activity
FX988_RS11005	COG0742	ribosomal rna small subunit methyltransferase
FX988_RS11010	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FX988_RS11020	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FX988_RS11030	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FX988_RS11035	COG1758	RNA polymerase activity
FX988_RS11040	COG0194	GDP metabolic process
FX988_RS11045	COG1965	Belongs to the frataxin family
FX988_RS11060	COG0181	hydroxymethylbilane synthase activity
FX988_RS11070	COG2959	enzyme of heme biosynthesis
FX988_RS11130	COG3550	peptidyl-serine autophosphorylation
FX988_RS11150	COG0456	acetyltransferase
FX988_RS11155	COG1490	D-aminoacyl-tRNA deacylase activity
FX988_RS11175	COG1295	ribonuclease BN
FX988_RS11180	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FX988_RS11190	COG0625	glutathione transferase activity
FX988_RS11200	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
FX988_RS11205	COG5001	Diguanylate cyclase
FX988_RS11205	COG5002	protein histidine kinase activity
FX988_RS11210	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FX988_RS11210	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
FX988_RS11215	COG3064	Membrane
FX988_RS11225	COG2957	Belongs to the agmatine deiminase family
FX988_RS11255	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
FX988_RS11265	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FX988_RS11270	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
FX988_RS11270	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FX988_RS11275	COG0802	atpase or kinase
FX988_RS11285	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FX988_RS11290	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FX988_RS11295	COG1923	regulation of RNA biosynthetic process
FX988_RS11300	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FX988_RS11305	COG0330	HflC and HflK could
FX988_RS11310	COG0330	HflC and HflK could
FX988_RS11325	COG0625	glutathione transferase activity
FX988_RS11335	COG1653	transport
FX988_RS11345	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
FX988_RS11350	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
FX988_RS11375	COG1960	acyl-CoA dehydrogenase activity
FX988_RS11380	COG0667	Aldo Keto reductase
FX988_RS11390	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FX988_RS11415	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
FX988_RS11425	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FX988_RS11445	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
FX988_RS11455	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FX988_RS11460	COG0438	transferase activity, transferring glycosyl groups
FX988_RS11465	COG0438	transferase activity, transferring glycosyl groups
FX988_RS11475	COG0438	transferase activity, transferring glycosyl groups
FX988_RS11485	COG0659	secondary active sulfate transmembrane transporter activity
FX988_RS11490	COG0288	reversible hydration of carbon dioxide
FX988_RS11495	COG0583	DNA-binding transcription factor activity
FX988_RS11515	COG0204	Acyl-transferase
FX988_RS11520	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FX988_RS11525	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FX988_RS11575	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FX988_RS11585	COG1028	Short-chain dehydrogenase reductase Sdr
FX988_RS11590	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FX988_RS11625	COG1448	Aminotransferase
FX988_RS11655	COG1765	OsmC-like protein
FX988_RS11670	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FX988_RS11675	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FX988_RS11680	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
FX988_RS11695	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FX988_RS11715	COG1573	uracil-dna glycosylase
FX988_RS11720	COG5001	Diguanylate cyclase
FX988_RS11720	COG3300	MHYT domain
FX988_RS11735	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FX988_RS11740	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FX988_RS11770	COG1842	Phage shock protein A
FX988_RS11780	COG1028	Short-chain dehydrogenase reductase Sdr
FX988_RS11790	COG2171	N-acyltransferase activity
FX988_RS11805	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FX988_RS11825	COG0204	Acyl-transferase
FX988_RS11830	COG0204	Acyl-transferase
FX988_RS11835	COG0668	transmembrane transport
FX988_RS11850	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FX988_RS11855	COG0733	neurotransmitter:sodium symporter activity
FX988_RS11870	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FX988_RS11880	COG3250	beta-galactosidase activity
FX988_RS11890	COG0716	FMN binding
FX988_RS11900	COG0848	biopolymer transport protein
FX988_RS11905	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FX988_RS11925	COG0019	diaminopimelate decarboxylase activity
FX988_RS11930	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FX988_RS11945	COG1011	Hydrolase
FX988_RS11950	COG1045	serine acetyltransferase
FX988_RS11955	COG0210	DNA helicase
FX988_RS11960	COG3706	GGDEF domain
FX988_RS11960	COG0745	RESPONSE REGULATOR receiver
FX988_RS11965	COG2962	Rard protein
FX988_RS12000	COG1597	lipid kinase activity
FX988_RS12000	COG1803	Methylglyoxal synthase
FX988_RS12010	COG0668	transmembrane transport
FX988_RS12040	COG2272	Belongs to the type-B carboxylesterase lipase family
FX988_RS12055	COG0583	DNA-binding transcription factor activity
FX988_RS12060	COG3118	belongs to the thioredoxin family
FX988_RS12075	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
FX988_RS12095	COG5001	Diguanylate cyclase
FX988_RS12095	COG2203	Gaf domain
FX988_RS12095	COG4251	negative regulation of phosphorylation
FX988_RS12095	COG3706	GGDEF domain
FX988_RS12105	COG5487	UPF0391 membrane protein
FX988_RS12110	COG2239	Acts as a magnesium transporter
FX988_RS12115	COG2911	Protein conserved in bacteria
FX988_RS12120	COG0729	surface antigen
FX988_RS12155	COG2050	protein possibly involved in aromatic compounds catabolism
FX988_RS12160	COG0514	ATP-dependent DNA helicase (RecQ)
FX988_RS12165	COG0305	Participates in initiation and elongation during chromosome replication
FX988_RS12170	COG2885	chlorophyll binding
FX988_RS12175	COG0432	Pfam Uncharacterised protein family UPF0047
FX988_RS12185	COG0735	belongs to the Fur family
FX988_RS12190	COG2816	NAD+ diphosphatase activity
FX988_RS12195	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FX988_RS12205	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FX988_RS12210	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
FX988_RS12220	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
FX988_RS12230	COG3156	type II secretion system protein K
FX988_RS12235	COG4795	General secretion pathway protein
FX988_RS12240	COG2165	general secretion pathway protein
FX988_RS12250	COG2165	general secretion pathway protein
FX988_RS12255	COG1459	type II secretion system
FX988_RS12260	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FX988_RS12270	COG3031	protein transport across the cell outer membrane
FX988_RS12285	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
FX988_RS12295	COG0745	RESPONSE REGULATOR receiver
FX988_RS12300	COG3954	Phosphoribulokinase
FX988_RS12330	COG0745	RESPONSE REGULATOR receiver
FX988_RS12335	COG5002	protein histidine kinase activity
FX988_RS12340	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
FX988_RS12345	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FX988_RS12360	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
FX988_RS12370	COG2326	polyphosphate kinase activity
FX988_RS12380	COG1621	beta-fructofuranosidase activity
FX988_RS12385	COG1609	Transcriptional regulator
FX988_RS12420	COG4771	TonB-dependent receptor
FX988_RS12430	COG1960	acyl-CoA dehydrogenase activity
FX988_RS12435	COG1960	acyl-CoA dehydrogenase activity
FX988_RS12450	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FX988_RS12455	COG1764	response to oxidative stress
FX988_RS12460	COG1846	Transcriptional regulator
FX988_RS12480	COG2264	protein methyltransferase activity
FX988_RS12490	COG0439	Biotin carboxylase
FX988_RS12495	COG0511	ligase activity, forming carbon-carbon bonds
FX988_RS12505	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
FX988_RS12510	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FX988_RS12520	COG4232	protein-disulfide reductase activity
FX988_RS12530	COG0745	RESPONSE REGULATOR receiver
FX988_RS12535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FX988_RS12535	COG4191	Histidine kinase
FX988_RS12545	COG0297	glycogen (starch) synthase activity
FX988_RS12550	COG2813	Specifically methylates the guanine in position
FX988_RS12555	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FX988_RS12570	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
FX988_RS12585	COG1793	dna ligase
FX988_RS12600	COG0210	DNA helicase
FX988_RS12615	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
FX988_RS12620	COG3161	chorismate lyase activity
FX988_RS12630	COG0705	Rhomboid family
FX988_RS12635	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FX988_RS12640	COG1063	alcohol dehydrogenase
FX988_RS12665	COG1519	Transferase
FX988_RS12675	COG3642	lipopolysaccharide core region biosynthetic process
FX988_RS12685	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FX988_RS12695	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FX988_RS12705	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FX988_RS12710	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FX988_RS12720	COG2003	Belongs to the UPF0758 family
FX988_RS12725	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FX988_RS12740	COG2234	aminopeptidase activity
FX988_RS12795	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FX988_RS12840	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
FX988_RS12850	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FX988_RS12855	COG3047	cAMP biosynthetic process
FX988_RS12865	COG0009	L-threonylcarbamoyladenylate synthase
FX988_RS12870	COG0551	DNA topoisomerase type I activity
FX988_RS12875	COG2922	Belongs to the Smg family
FX988_RS12880	COG0758	DNA mediated transformation
FX988_RS12895	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FX988_RS12900	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FX988_RS12900	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FX988_RS12905	COG0569	domain protein
FX988_RS12925	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FX988_RS12930	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FX988_RS12930	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FX988_RS12940	COG0218	Necessary for normal cell division and for the maintenance of normal septation
FX988_RS12960	COG2818	Glycosylase
FX988_RS12965	COG0752	glycyl-tRNA synthetase alpha subunit
FX988_RS12970	COG0751	glycine-tRNA ligase activity
FX988_RS12980	COG5001	Diguanylate cyclase
FX988_RS12980	COG3447	MASE1 domain protein
FX988_RS12980	COG5002	protein histidine kinase activity
FX988_RS12985	COG1794	racemase activity, acting on amino acids and derivatives
FX988_RS12990	COG0187	DNA topoisomerase II activity
FX988_RS12995	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FX988_RS13005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FX988_RS13010	COG0230	Belongs to the bacterial ribosomal protein bL34 family
FX988_RS13015	COG0594	ribonuclease P activity
FX988_RS13020	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
FX988_RS13025	COG0706	membrane insertase activity
FX988_RS13030	COG1666	GTP binding
FX988_RS13035	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FX988_RS13040	COG0716	FMN binding
FX988_RS13055	COG0445	tRNA wobble uridine modification
FX988_RS13060	COG0357	Ribosomal RNA small subunit methyltransferase G
FX988_RS13065	COG1192	Involved in chromosome partitioning
FX988_RS13070	COG1475	DNA binding
FX988_RS13075	COG3312	ion transport
FX988_RS13080	COG0356	it plays a direct role in the translocation of protons across the membrane
FX988_RS13090	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FX988_RS13095	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FX988_RS13100	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FX988_RS13105	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FX988_RS13110	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FX988_RS13115	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FX988_RS13120	COG2198	Histidine kinase
FX988_RS13120	COG0784	Response regulator, receiver
FX988_RS13120	COG5002	protein histidine kinase activity
FX988_RS13160	COG2199	diguanylate cyclase activity
FX988_RS13160	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
FX988_RS13175	COG2814	Major facilitator Superfamily
FX988_RS13185	COG0659	secondary active sulfate transmembrane transporter activity
FX988_RS13190	COG1561	YicC-like family, N-terminal region
FX988_RS13195	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
FX988_RS13200	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FX988_RS13205	COG0425	Belongs to the sulfur carrier protein TusA family
FX988_RS13225	COG1228	amidohydrolase
FX988_RS13250	COG0628	permease
FX988_RS13265	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
FX988_RS13270	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
FX988_RS13275	COG1252	NADH dehydrogenase
FX988_RS13295	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FX988_RS13305	COG2814	Major facilitator Superfamily
FX988_RS13320	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FX988_RS13325	COG0583	DNA-binding transcription factor activity
FX988_RS13335	COG0606	chelatase, subunit chli
FX988_RS13345	COG0129	dihydroxy-acid dehydratase activity
FX988_RS13355	COG2937	Belongs to the GPAT DAPAT family
FX988_RS13365	COG1215	transferase activity, transferring glycosyl groups
FX988_RS13375	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
FX988_RS13380	COG0457	Tetratricopeptide repeat
FX988_RS13385	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FX988_RS13390	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FX988_RS13395	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FX988_RS13405	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
FX988_RS13430	COG1612	heme a metabolic process
FX988_RS13435	COG0109	protoheme IX farnesyltransferase activity
FX988_RS13450	COG0726	polysaccharide deacetylase
FX988_RS13450	COG1649	PFAM Uncharacterised BCR, COG1649
FX988_RS13455	COG0534	Mate efflux family protein
FX988_RS13460	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
FX988_RS13460	COG0316	Belongs to the HesB IscA family
FX988_RS13470	COG1040	competence protein
FX988_RS13475	COG0596	Alpha beta hydrolase
FX988_RS13495	COG2183	response to ionizing radiation
FX988_RS13505	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FX988_RS13510	COG0545	Peptidyl-prolyl cis-trans isomerase
FX988_RS13520	COG2900	Belongs to the SlyX family
FX988_RS13530	COG0488	(ABC) transporter
FX988_RS13540	COG0583	DNA-binding transcription factor activity
FX988_RS13545	COG2855	membrane
FX988_RS13555	COG3537	Alpha-1,2-mannosidase
FX988_RS13570	COG3537	Alpha-1,2-mannosidase
FX988_RS13575	COG1609	Transcriptional regulator
FX988_RS13590	COG2971	BadF BadG BcrA BcrD
FX988_RS13595	COG1446	asparaginase
FX988_RS13615	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FX988_RS13620	COG3537	Alpha-1,2-mannosidase
FX988_RS13630	COG0429	hydrolase of the alpha beta-hydrolase fold
FX988_RS13635	COG3089	Belongs to the UPF0270 family
FX988_RS13645	COG1218	3'(2'),5'-bisphosphate nucleotidase
FX988_RS13650	COG0494	nUDIX hydrolase
FX988_RS13655	COG1011	Hydrolase
FX988_RS13660	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FX988_RS13685	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FX988_RS13690	COG2814	Major facilitator Superfamily
FX988_RS13695	COG0629	single-stranded DNA binding
FX988_RS13700	COG4771	TonB-dependent receptor
FX988_RS13715	COG1012	belongs to the aldehyde dehydrogenase family
FX988_RS13720	COG0318	PFAM AMP-dependent synthetase and ligase
FX988_RS13725	COG4771	TonB-dependent receptor
FX988_RS13740	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FX988_RS13750	COG3391	amine dehydrogenase activity
FX988_RS13755	COG1309	transcriptional regulator
FX988_RS13760	COG3706	GGDEF domain
FX988_RS13760	COG0745	RESPONSE REGULATOR receiver
FX988_RS13770	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FX988_RS13810	COG3409	Peptidoglycan-binding domain 1 protein
FX988_RS13810	COG3267	Type II secretory pathway component ExeA
FX988_RS13825	COG1459	type II secretion system
FX988_RS13870	COG1077	Cell shape determining protein MreB Mrl
FX988_RS13875	COG1792	Involved in formation and maintenance of cell shape
FX988_RS13880	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
FX988_RS13885	COG0424	maF-like protein
FX988_RS13890	COG1530	ribonuclease E activity
FX988_RS13895	COG3164	Protein of unknown function
FX988_RS13900	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FX988_RS13905	COG0312	modulator of DNA gyrase
FX988_RS13915	COG3028	Belongs to the UPF0307 family
FX988_RS13920	COG0312	modulator of DNA gyrase
FX988_RS13945	COG0006	proline dipeptidase activity
FX988_RS13955	COG1024	Enoyl-CoA hydratase
FX988_RS13955	COG1250	3-hydroxyacyl-CoA dehydrogenase
FX988_RS13960	COG0183	Belongs to the thiolase family
FX988_RS13980	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
FX988_RS13990	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
FX988_RS13995	COG3118	belongs to the thioredoxin family
FX988_RS14000	COG0513	Belongs to the DEAD box helicase family
FX988_RS14005	COG0248	Ppx GppA phosphatase
FX988_RS14015	COG3706	GGDEF domain
FX988_RS14015	COG0745	RESPONSE REGULATOR receiver
FX988_RS14020	COG0084	hydrolase, TatD family'
FX988_RS14030	COG0805	protein transport
FX988_RS14035	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FX988_RS14070	COG0339	signal peptide processing
FX988_RS14075	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FX988_RS14085	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FX988_RS14090	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FX988_RS14120	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FX988_RS14145	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
FX988_RS14150	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
FX988_RS14155	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FX988_RS14160	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FX988_RS14165	COG0254	rRNA binding
FX988_RS14170	COG0281	malic enzyme
FX988_RS14190	COG0840	transmembrane signaling receptor activity
FX988_RS14205	COG0488	(ABC) transporter
FX988_RS14215	COG3706	GGDEF domain
FX988_RS14215	COG2203	Gaf domain
FX988_RS14215	COG4251	negative regulation of phosphorylation
FX988_RS14215	COG5001	Diguanylate cyclase
FX988_RS14220	COG1619	proteins homologs of microcin C7 resistance protein MccF
FX988_RS14230	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FX988_RS14255	COG2971	BadF BadG BcrA BcrD
FX988_RS14260	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
FX988_RS14265	COG3876	Protein conserved in bacteria
FX988_RS14280	COG1737	Transcriptional regulator
FX988_RS14300	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FX988_RS14315	COG0456	acetyltransferase
FX988_RS14315	COG0454	-acetyltransferase
FX988_RS14320	COG2204	response regulator
FX988_RS14330	COG4251	negative regulation of phosphorylation
FX988_RS14335	COG0784	Response regulator, receiver
FX988_RS14365	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FX988_RS14375	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
FX988_RS14380	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FX988_RS14395	COG1295	ribonuclease BN
FX988_RS14430	COG4325	translation initiation factor activity
FX988_RS14435	COG0656	L-ascorbic acid biosynthetic process
FX988_RS14465	COG2814	Major facilitator Superfamily
FX988_RS14480	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FX988_RS14485	COG1309	transcriptional regulator
FX988_RS14500	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FX988_RS14510	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FX988_RS14570	COG4774	siderophore transport
FX988_RS14570	COG1629	transport
FX988_RS14640	COG0569	domain protein
FX988_RS14645	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FX988_RS14650	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FX988_RS14655	COG1609	Transcriptional regulator
FX988_RS14660	COG4948	Mandelate Racemase Muconate Lactonizing
FX988_RS14705	COG4771	TonB-dependent receptor
FX988_RS14735	COG1469	GTP cyclohydrolase I activity
FX988_RS14760	COG1136	(ABC) transporter
FX988_RS14775	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FX988_RS14780	COG4773	Receptor
FX988_RS14800	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
FX988_RS14805	COG2177	Part of the ABC transporter FtsEX involved in
FX988_RS14810	COG2884	Cell division ATP-binding protein ftsE
FX988_RS14815	COG0552	protein localization to endoplasmic reticulum
FX988_RS14820	COG0742	ribosomal rna small subunit methyltransferase
FX988_RS14830	COG2095	MarC family integral membrane protein
FX988_RS14845	COG1489	DNA binding
FX988_RS14850	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FX988_RS14855	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FX988_RS14870	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
FX988_RS14875	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
FX988_RS14880	COG0076	glutamate decarboxylase activity
FX988_RS14895	COG0842	Transport permease protein
FX988_RS14900	COG1131	(ABC) transporter
FX988_RS14905	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FX988_RS14920	COG2304	oxidoreductase activity
FX988_RS14925	COG2885	chlorophyll binding
FX988_RS14930	COG0745	RESPONSE REGULATOR receiver
FX988_RS14935	COG2205	protein histidine kinase activity
FX988_RS14940	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
FX988_RS14950	COG0583	DNA-binding transcription factor activity
FX988_RS14955	COG5002	protein histidine kinase activity
FX988_RS14955	COG0784	Response regulator, receiver
FX988_RS14955	COG2205	protein histidine kinase activity
FX988_RS14965	COG1960	acyl-CoA dehydrogenase activity
FX988_RS14980	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FX988_RS14990	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FX988_RS14995	COG2199	diguanylate cyclase activity
FX988_RS14995	COG2203	Gaf domain
FX988_RS15000	COG0697	spore germination
FX988_RS15005	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FX988_RS15020	COG1166	arginine decarboxylase activity
FX988_RS15025	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FX988_RS15025	COG3153	acetyltransferase
FX988_RS15030	COG1476	TRANSCRIPTIONal
FX988_RS15055	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
FX988_RS15060	COG0653	protein targeting
FX988_RS15080	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FX988_RS15085	COG1388	LysM domain
FX988_RS15085	COG4942	peptidase
FX988_RS15095	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FX988_RS15100	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
FX988_RS15105	COG0585	pseudouridine synthase activity
FX988_RS15110	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
FX988_RS15115	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FX988_RS15120	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
FX988_RS15135	COG1280	lysine exporter protein (LysE YggA)
FX988_RS15140	COG4991	sh3 domain protein
FX988_RS15145	COG3025	triphosphatase activity
FX988_RS15155	COG1012	belongs to the aldehyde dehydrogenase family
FX988_RS15160	COG3066	DNA modification
FX988_RS15170	COG0494	nUDIX hydrolase
FX988_RS15180	COG0730	response to heat
FX988_RS15185	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FX988_RS15195	COG0783	Belongs to the Dps family
FX988_RS15205	COG2067	long-chain fatty acid transport protein
FX988_RS15215	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
FX988_RS15225	COG3706	GGDEF domain
FX988_RS15230	COG2814	Major facilitator Superfamily
FX988_RS15250	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FX988_RS15255	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
FX988_RS15280	COG0625	glutathione transferase activity
FX988_RS15285	COG1621	beta-fructofuranosidase activity
FX988_RS15290	COG2814	Major facilitator Superfamily
FX988_RS15295	COG1609	Transcriptional regulator
FX988_RS15325	COG1914	H( )-stimulated, divalent metal cation uptake system
FX988_RS15350	COG2267	carboxylic ester hydrolase activity
FX988_RS15390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FX988_RS15395	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FX988_RS15400	COG1538	Outer membrane efflux protein
FX988_RS15415	COG4771	TonB-dependent receptor
FX988_RS15450	COG1960	acyl-CoA dehydrogenase activity
FX988_RS15500	COG1131	(ABC) transporter
FX988_RS15525	COG3706	GGDEF domain
FX988_RS15535	COG1309	transcriptional regulator
FX988_RS15550	COG3344	reverse transcriptase
FX988_RS15575	COG1122	ATPase activity
FX988_RS15585	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
FX988_RS15590	COG0732	type I restriction modification DNA specificity domain
FX988_RS15595	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
FX988_RS15630	COG0582	viral genome integration into host DNA
FX988_RS15635	COG0459	protein refolding
FX988_RS15640	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FX988_RS15655	COG0493	'glutamate synthase
FX988_RS15660	COG0070	glutamate synthase
FX988_RS15660	COG0067	glutamate synthase
FX988_RS15660	COG0069	glutamate synthase activity
FX988_RS15670	COG2198	Histidine kinase
FX988_RS15670	COG0784	Response regulator, receiver
FX988_RS15670	COG5002	protein histidine kinase activity
FX988_RS15680	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FX988_RS15685	COG0359	binds to the 23S rRNA
FX988_RS15715	COG0142	geranyltranstransferase activity
FX988_RS15720	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FX988_RS15725	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FX988_RS15730	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FX988_RS15745	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
FX988_RS15750	COG1278	Cold shock
FX988_RS15755	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FX988_RS15780	COG0477	Major facilitator Superfamily
FX988_RS15785	COG2115	Belongs to the xylose isomerase family
FX988_RS15790	COG1070	Carbohydrate kinase
FX988_RS15795	COG1609	Transcriptional regulator
FX988_RS15795	COG2207	Transcriptional regulator
FX988_RS15800	COG3850	Histidine kinase
FX988_RS15800	COG4999	Histidine kinase
FX988_RS15800	COG2205	protein histidine kinase activity
FX988_RS15800	COG3437	response regulator, receiver
FX988_RS15815	COG0762	integral membrane protein
FX988_RS15820	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FX988_RS15850	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FX988_RS15855	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FX988_RS15865	COG1381	Involved in DNA repair and RecF pathway recombination
FX988_RS15870	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
FX988_RS15875	COG0736	holo-[acyl-carrier-protein] synthase activity
FX988_RS15880	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FX988_RS15885	COG3956	TIGRFAM MazG family protein
FX988_RS15900	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FX988_RS15905	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FX988_RS15910	COG0723	plastoquinol--plastocyanin reductase activity
FX988_RS15915	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
FX988_RS15920	COG2857	Cytochrome c1
FX988_RS15925	COG0625	glutathione transferase activity
FX988_RS15930	COG2969	positive regulation of protein catabolic process
FX988_RS15935	COG2823	Periplasmic or secreted lipoprotein
FX988_RS15940	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
FX988_RS15945	COG0792	nuclease activity
FX988_RS15955	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
FX988_RS16000	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FX988_RS16005	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FX988_RS16015	COG0625	glutathione transferase activity
FX988_RS16030	COG0745	RESPONSE REGULATOR receiver
FX988_RS16040	COG2207	Transcriptional regulator
FX988_RS16045	COG1979	alcohol dehydrogenase
FX988_RS16050	COG0668	transmembrane transport
FX988_RS16070	COG4067	protein conserved in archaea
FX988_RS16070	COG0189	ligase activity
FX988_RS16075	COG0189	ligase activity
FX988_RS16080	COG0598	Magnesium transport protein CorA
FX988_RS16090	COG1028	Short-chain dehydrogenase reductase Sdr
FX988_RS16095	COG2186	Transcriptional regulator
FX988_RS16105	COG2271	Major facilitator Superfamily
FX988_RS16110	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FX988_RS16115	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
FX988_RS16120	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
FX988_RS16125	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
FX988_RS16130	COG2199	diguanylate cyclase activity
FX988_RS16150	COG1609	Transcriptional regulator
FX988_RS16165	COG1028	Short-chain dehydrogenase reductase Sdr
FX988_RS16180	COG0246	Mannitol dehydrogenase
FX988_RS16205	COG3265	gluconokinase activity
FX988_RS16210	COG1914	H( )-stimulated, divalent metal cation uptake system
FX988_RS16255	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
FX988_RS16270	COG3706	GGDEF domain
FX988_RS16270	COG0745	RESPONSE REGULATOR receiver
FX988_RS16275	COG0417	DNA replication proofreading
FX988_RS16285	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
FX988_RS16310	COG0166	Belongs to the GPI family
FX988_RS16315	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FX988_RS16325	COG3022	response to hydroperoxide
FX988_RS16345	COG4682	membrane
FX988_RS16350	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FX988_RS16355	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
FX988_RS16365	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FX988_RS16370	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
FX988_RS16375	COG4942	peptidase
FX988_RS16380	COG2861	carbohydrate metabolic process
FX988_RS16385	COG2354	Protein conserved in bacteria
FX988_RS16390	COG4572	Cation transport regulator
FX988_RS16405	COG5002	protein histidine kinase activity
FX988_RS16405	COG2205	protein histidine kinase activity
FX988_RS16405	COG0784	Response regulator, receiver
FX988_RS16410	COG1560	Kdo2-lipid A biosynthetic process
FX988_RS16425	COG2827	Endonuclease containing a URI domain
FX988_RS16450	COG1272	protein, Hemolysin III
FX988_RS16455	COG3267	Type II secretory pathway component ExeA
FX988_RS16455	COG3409	Peptidoglycan-binding domain 1 protein
FX988_RS16465	COG0583	DNA-binding transcription factor activity
FX988_RS16470	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FX988_RS16475	COG0509	glycine decarboxylation via glycine cleavage system
FX988_RS16540	COG3119	arylsulfatase activity
FX988_RS16575	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FX988_RS16585	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FX988_RS16590	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
FX988_RS16595	COG0348	domain, Protein
FX988_RS16605	COG0745	RESPONSE REGULATOR receiver
FX988_RS16630	COG5001	Diguanylate cyclase
FX988_RS16630	COG2203	Gaf domain
FX988_RS16630	COG4251	negative regulation of phosphorylation
FX988_RS16630	COG3706	GGDEF domain
FX988_RS16635	COG0737	Belongs to the 5'-nucleotidase family
FX988_RS16640	COG0525	valine-tRNA ligase activity
FX988_RS16645	COG2927	DNA polymerase III (CHI subunit)
FX988_RS16650	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FX988_RS16660	COG0795	lipopolysaccharide-transporting ATPase activity
FX988_RS16665	COG0795	lipopolysaccharide-transporting ATPase activity
FX988_RS16680	COG3209	COG3209 Rhs family protein
FX988_RS16725	COG3706	GGDEF domain
FX988_RS16730	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FX988_RS16745	COG2201	protein-glutamate methylesterase activity
FX988_RS16750	COG4191	Histidine kinase
FX988_RS16755	COG5001	Diguanylate cyclase
FX988_RS16755	COG3300	MHYT domain
FX988_RS16760	COG1404	Belongs to the peptidase S8 family
FX988_RS16815	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FX988_RS16820	COG2186	Transcriptional regulator
FX988_RS16835	COG1028	Short-chain dehydrogenase reductase Sdr
FX988_RS16840	COG2001	Belongs to the MraZ family
FX988_RS16845	COG0275	rRNA processing
FX988_RS16850	COG3116	cell division
FX988_RS16855	COG0768	penicillin binding
FX988_RS16860	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FX988_RS16865	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FX988_RS16870	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FX988_RS16875	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FX988_RS16880	COG0772	Belongs to the SEDS family
FX988_RS16885	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FX988_RS16890	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FX988_RS16895	COG1181	Belongs to the D-alanine--D-alanine ligase family
FX988_RS16900	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FX988_RS16905	COG0849	cell division
FX988_RS16910	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FX988_RS16915	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
FX988_RS16920	COG0739	heme binding
FX988_RS16925	COG0653	protein targeting
FX988_RS16930	COG0494	nUDIX hydrolase
FX988_RS16935	COG0583	DNA-binding transcription factor activity
FX988_RS16940	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
FX988_RS16990	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
FX988_RS16995	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FX988_RS17000	COG1957	nucleoside hydrolase
FX988_RS17005	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FX988_RS17020	COG3079	Belongs to the UPF0149 family
FX988_RS17025	COG0006	proline dipeptidase activity
FX988_RS17030	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FX988_RS17035	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FX988_RS17040	COG2095	MarC family integral membrane protein
FX988_RS17065	COG0714	Associated with various cellular activities
FX988_RS17075	COG0312	modulator of DNA gyrase
FX988_RS17080	COG0312	modulator of DNA gyrase
FX988_RS17105	COG0584	glycerophosphoryl diester phosphodiesterase
FX988_RS17115	COG0688	phosphatidylethanolamine metabolic process
FX988_RS17120	COG1162	GTPase activity
FX988_RS17125	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
FX988_RS17145	COG2116	formate transmembrane transporter activity
FX988_RS17150	COG0515	serine threonine protein kinase
FX988_RS17150	COG2815	serine threonine protein kinase
FX988_RS17155	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
FX988_RS17165	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FX988_RS17175	COG1187	pseudouridine synthase activity
FX988_RS17195	COG1522	sequence-specific DNA binding
FX988_RS17225	COG0405	Gamma-glutamyltransferase
FX988_RS17230	COG2999	glutathione oxidoreductase activity
FX988_RS17240	COG1061	Type III restriction enzyme res subunit
FX988_RS17245	COG2814	Major facilitator Superfamily
FX988_RS17270	COG0419	ATPase involved in DNA repair
FX988_RS17275	COG0420	3'-5' exonuclease activity
FX988_RS17280	COG4771	TonB-dependent receptor
FX988_RS17305	COG3240	lipase activity
FX988_RS17310	COG1132	(ABC) transporter
FX988_RS17315	COG0242	peptide deformylase activity
FX988_RS17320	COG2951	lytic endotransglycosylase activity
FX988_RS17330	COG0693	protein deglycase activity
FX988_RS17355	COG0527	aspartate kinase activity
FX988_RS17375	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FX988_RS17380	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FX988_RS17385	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FX988_RS17390	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
FX988_RS17405	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
FX988_RS17420	COG2205	protein histidine kinase activity
FX988_RS17445	COG2873	o-acetylhomoserine
FX988_RS17480	COG0640	Transcriptional regulator
FX988_RS17490	COG0431	NADPH-dependent FMN reductase
FX988_RS17495	COG0798	PFAM Bile acid sodium symporter
FX988_RS17500	COG2171	N-acyltransferase activity
FX988_RS17535	COG3101	peptidyl-lysine hydroxylation
FX988_RS17550	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FX988_RS17550	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
FX988_RS17555	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FX988_RS17565	COG2308	Evidence 4 Homologs of previously reported genes of
FX988_RS17585	COG2226	methyltransferase
FX988_RS17590	COG3083	sulfuric ester hydrolase activity
FX988_RS17595	COG3082	Protein of unknown function (DUF1414)
FX988_RS17600	COG3081	Nucleoid-associated protein
FX988_RS17625	COG2200	EAL domain
FX988_RS17640	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FX988_RS17655	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FX988_RS17675	COG5001	Diguanylate cyclase
FX988_RS17675	COG3300	MHYT domain
FX988_RS17705	COG3313	Fe-S protein
FX988_RS17710	COG3590	peptidase
FX988_RS17715	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FX988_RS17720	COG0508	dehydrogenase complex catalyzes the overall conversion of
FX988_RS17725	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
FX988_RS17730	COG2186	Transcriptional regulator
FX988_RS17735	COG3725	Membrane protein required for beta-lactamase induction
FX988_RS17740	COG3023	N-Acetylmuramoyl-L-alanine amidase
FX988_RS17760	COG1459	type II secretion system
FX988_RS17765	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
FX988_RS17770	COG0237	dephospho-CoA kinase activity
FX988_RS17775	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
FX988_RS17785	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FX988_RS17785	COG0678	peroxiredoxin activity
FX988_RS17805	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FX988_RS17810	COG0668	transmembrane transport
FX988_RS17815	COG4783	chaperone-mediated protein folding
FX988_RS17820	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FX988_RS17825	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FX988_RS17830	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FX988_RS17835	COG0126	phosphoglycerate kinase activity
FX988_RS17840	COG3588	fructose-bisphosphate aldolase
FX988_RS17860	COG0248	Ppx GppA phosphatase
FX988_RS17865	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
FX988_RS17875	COG1392	Phosphate transport regulator
FX988_RS17880	COG0306	phosphate transporter
FX988_RS17890	COG0573	inorganic phosphate transmembrane transporter activity
FX988_RS17895	COG0581	inorganic phosphate transmembrane transporter activity
FX988_RS17900	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FX988_RS17910	COG3746	phosphate-selective porin O and P
FX988_RS17915	COG0583	DNA-binding transcription factor activity
FX988_RS17920	COG1595	DNA-templated transcription, initiation
FX988_RS17955	COG2910	NAD(P)H-binding
FX988_RS17960	COG0583	DNA-binding transcription factor activity
FX988_RS17980	COG2271	Major facilitator Superfamily
FX988_RS17995	COG2204	response regulator
FX988_RS18005	COG1346	cytolysis
FX988_RS18030	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FX988_RS18035	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FX988_RS18060	COG0513	Belongs to the DEAD box helicase family
FX988_RS18070	COG0617	tRNA 3'-terminal CCA addition
FX988_RS18075	COG3409	Peptidoglycan-binding domain 1 protein
FX988_RS18075	COG3267	Type II secretory pathway component ExeA
FX988_RS18105	COG2211	Major facilitator Superfamily
FX988_RS18110	COG3459	Glycosyltransferase 36 associated
FX988_RS18120	COG1609	Transcriptional regulator
FX988_RS18125	COG0066	3-isopropylmalate dehydratase activity
FX988_RS18130	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FX988_RS18135	COG0473	3-isopropylmalate dehydrogenase activity
FX988_RS18140	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FX988_RS18150	COG0148	phosphopyruvate hydratase activity
FX988_RS18155	COG0504	CTP synthase activity
FX988_RS18160	COG0745	RESPONSE REGULATOR receiver
FX988_RS18165	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FX988_RS18190	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FX988_RS18215	COG4133	protoheme IX ABC transporter activity
FX988_RS18220	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FX988_RS18225	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FX988_RS18230	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FX988_RS18235	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
FX988_RS18240	COG1138	Cytochrome C-type biogenesis protein
FX988_RS18250	COG4235	cytochrome complex assembly
FX988_RS18250	COG3088	subunit of a heme lyase
FX988_RS18265	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FX988_RS18275	COG3104	oligopeptide transport
FX988_RS18290	COG1086	Polysaccharide biosynthesis protein
FX988_RS18295	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
FX988_RS18305	COG2089	acid synthase
FX988_RS18315	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
FX988_RS18330	COG0463	Glycosyl transferase, family 2
FX988_RS18345	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FX988_RS18350	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FX988_RS18375	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FX988_RS18385	COG0473	3-isopropylmalate dehydrogenase activity
FX988_RS18400	COG1611	Belongs to the LOG family
FX988_RS18450	COG0564	pseudouridine synthase activity
FX988_RS18465	COG0268	Binds directly to 16S ribosomal RNA
FX988_RS18470	COG0728	peptidoglycan biosynthetic process
FX988_RS18475	COG0196	riboflavin kinase activity
FX988_RS18480	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FX988_RS18485	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FX988_RS18490	COG1047	Peptidyl-prolyl cis-trans
FX988_RS18495	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
FX988_RS18530	COG4968	Prepilin-type N-terminal cleavage methylation domain
FX988_RS18555	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FX988_RS18565	COG1047	Peptidyl-prolyl cis-trans
FX988_RS18570	COG0354	folic acid binding
FX988_RS18575	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
FX988_RS18590	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
FX988_RS18595	COG1595	DNA-templated transcription, initiation
FX988_RS18610	COG3086	response to oxidative stress
FX988_RS18615	COG0481	GTPase activity
FX988_RS18620	COG0681	Belongs to the peptidase S26 family
FX988_RS18630	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FX988_RS18635	COG0259	pyridoxamine-phosphate oxidase activity
FX988_RS18640	COG0084	hydrolase, TatD family'
FX988_RS18650	COG1131	(ABC) transporter
FX988_RS18675	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FX988_RS18705	COG0544	peptidyl-prolyl cis-trans isomerase activity
FX988_RS18710	COG0740	serine-type endopeptidase activity
FX988_RS18715	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FX988_RS18720	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FX988_RS18725	COG0776	regulation of translation
FX988_RS18730	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FX988_RS18735	COG0105	UTP biosynthetic process
FX988_RS18740	COG0820	rRNA (adenine-C2-)-methyltransferase activity
FX988_RS18745	COG3063	Type IV pilus biogenesis stability protein PilW
FX988_RS18760	COG0124	histidyl-tRNA synthetase
FX988_RS18765	COG2976	Protein conserved in bacteria
FX988_RS18770	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FX988_RS18775	COG1160	GTP binding
FX988_RS18780	COG1570	exodeoxyribonuclease VII activity
FX988_RS18785	COG0517	IMP dehydrogenase activity
FX988_RS18785	COG0516	GMP reductase activity
FX988_RS18790	COG0519	Catalyzes the synthesis of GMP from XMP
FX988_RS18790	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FX988_RS18810	COG0590	tRNA wobble adenosine to inosine editing
FX988_RS18815	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
FX988_RS18820	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FX988_RS18820	COG0047	phosphoribosylformylglycinamidine synthase activity
FX988_RS18840	COG4772	TonB-dependent receptor
FX988_RS18875	COG0784	Response regulator, receiver
FX988_RS18875	COG0835	chemotaxis
FX988_RS18880	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
FX988_RS18885	COG1815	bacterial-type flagellum-dependent cell motility
FX988_RS18890	COG1558	bacterial-type flagellum-dependent cell motility
FX988_RS18895	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
FX988_RS18900	COG1749	Flagellar hook protein flgE
FX988_RS18905	COG4787	bacterial-type flagellum-dependent cell motility
FX988_RS18910	COG4786	Flagellar basal body rod
FX988_RS18920	COG1706	bacterial-type flagellum-dependent cell motility
FX988_RS18925	COG3951	Flagellar rod assembly protein muramidase FlgJ
FX988_RS18925	COG1705	Flagellar rod assembly protein muramidase FlgJ
FX988_RS18930	COG1256	bacterial-type flagellum assembly
FX988_RS18930	COG4786	Flagellar basal body rod
FX988_RS18935	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FX988_RS18950	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FX988_RS18960	COG1334	flagellar protein FlaG
FX988_RS18965	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
FX988_RS18980	COG1086	Polysaccharide biosynthesis protein
FX988_RS18985	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
FX988_RS18990	COG1083	cytidylyl-transferase
FX988_RS19000	COG2089	acid synthase
FX988_RS19020	COG0318	PFAM AMP-dependent synthetase and ligase
FX988_RS19025	COG1028	Short-chain dehydrogenase reductase Sdr
FX988_RS19030	COG1215	transferase activity, transferring glycosyl groups
FX988_RS19045	COG2226	methyltransferase
FX988_RS19055	COG1216	Glycosyl transferase, family 2
FX988_RS19060	COG2226	methyltransferase
FX988_RS19065	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
FX988_RS19070	COG0673	inositol 2-dehydrogenase activity
FX988_RS19105	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FX988_RS19110	COG2204	response regulator
FX988_RS19115	COG3852	Histidine kinase
FX988_RS19120	COG2204	response regulator
FX988_RS19135	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FX988_RS19185	COG1987	bacterial-type flagellum assembly
FX988_RS19195	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
FX988_RS19200	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
FX988_RS19210	COG0455	bacterial-type flagellum organization
FX988_RS19225	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
FX988_RS19230	COG0643	Histidine kinase
FX988_RS19230	COG2198	Histidine kinase
FX988_RS19235	COG2201	protein-glutamate methylesterase activity
FX988_RS19240	COG1192	Involved in chromosome partitioning
FX988_RS19250	COG0835	chemotaxis
FX988_RS19260	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
FX988_RS19265	COG0646	methionine synthase
FX988_RS19265	COG1410	methionine synthase
FX988_RS19270	COG0646	methionine synthase
FX988_RS19270	COG1410	methionine synthase
FX988_RS19285	COG2137	regulation of response to DNA damage stimulus
FX988_RS19290	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FX988_RS19295	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
FX988_RS19315	COG3630	sodium ion export across plasma membrane
FX988_RS19320	COG0511	ligase activity, forming carbon-carbon bonds
FX988_RS19320	COG5016	pyruvate
FX988_RS19325	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
FX988_RS19330	COG4172	Belongs to the ABC transporter superfamily
FX988_RS19340	COG4171	peptide transport system, permease
FX988_RS19345	COG4168	peptide transport system, permease
FX988_RS19350	COG0747	negative chemotaxis
FX988_RS19355	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
FX988_RS19360	COG1842	Phage shock protein A
FX988_RS19375	COG3106	COG3106 Predicted ATPase
FX988_RS19380	COG3768	UPF0283 membrane protein
FX988_RS19400	COG1522	sequence-specific DNA binding
FX988_RS19405	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FX988_RS19445	COG0811	peptide transport
FX988_RS19450	COG0811	peptide transport
FX988_RS19455	COG0848	biopolymer transport protein
FX988_RS19485	COG0443	Heat shock 70 kDa protein
FX988_RS19500	COG4895	conserved protein (DUF2196)
FX988_RS19505	COG2207	Transcriptional regulator
FX988_RS19510	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FX988_RS19515	COG4660	Part of a membrane complex involved in electron transport
FX988_RS19520	COG4659	FMN binding
FX988_RS19525	COG4658	electron transport chain
FX988_RS19535	COG2878	Part of a membrane complex involved in electron transport
FX988_RS19540	COG4657	Part of a membrane complex involved in electron transport
FX988_RS19560	COG0556	nucleotide-excision repair
FX988_RS19570	COG2205	protein histidine kinase activity
FX988_RS19570	COG0784	Response regulator, receiver
FX988_RS19570	COG5002	protein histidine kinase activity
FX988_RS19575	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
FX988_RS19580	COG0602	queuosine metabolic process
FX988_RS19595	COG0604	alcohol dehydrogenase
FX988_RS19600	COG1028	Short-chain dehydrogenase reductase Sdr
FX988_RS19605	COG0367	asparagine synthase
FX988_RS19625	COG4555	ABC transporter
FX988_RS19630	COG1668	transmembrane transport
FX988_RS19640	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FX988_RS19645	COG0494	nUDIX hydrolase
FX988_RS19650	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
FX988_RS19655	COG0632	four-way junction helicase activity
FX988_RS19660	COG2255	four-way junction helicase activity
FX988_RS19665	COG0824	Thioesterase
FX988_RS19670	COG0811	peptide transport
FX988_RS19685	COG0823	Involved in the tonB-independent uptake of proteins
FX988_RS19690	COG2885	chlorophyll binding
FX988_RS19695	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
FX988_RS19710	COG1639	'signal transduction protein
FX988_RS19730	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
FX988_RS19755	COG1024	Enoyl-CoA hydratase
FX988_RS19760	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FX988_RS19765	COG1960	acyl-CoA dehydrogenase activity
FX988_RS19775	COG0183	Belongs to the thiolase family
FX988_RS19790	COG0745	RESPONSE REGULATOR receiver
FX988_RS19810	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FX988_RS19845	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FX988_RS19855	COG2755	lipolytic protein G-D-S-L family
FX988_RS19860	COG4181	ATPase activity
FX988_RS19865	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
FX988_RS19870	COG1090	epimerase
FX988_RS19875	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FX988_RS19880	COG0628	permease
FX988_RS19890	COG0523	cobalamin synthesis protein
FX988_RS19895	COG3706	GGDEF domain
FX988_RS19905	COG3220	belongs to the UPF0276 family
FX988_RS19915	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FX988_RS19930	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
FX988_RS19935	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FX988_RS19940	COG0326	Molecular chaperone. Has ATPase activity
FX988_RS19945	COG0563	adenylate kinase activity
FX988_RS19960	COG2353	YceI-like domain
FX988_RS19965	COG3038	cytochrome b561
FX988_RS19970	COG0140	phosphoribosyl-ATP diphosphatase activity
FX988_RS19970	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FX988_RS19975	COG0107	imidazoleglycerol-phosphate synthase activity
FX988_RS19980	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FX988_RS19985	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
FX988_RS19990	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
FX988_RS19995	COG0131	Imidazoleglycerol-phosphate dehydratase
FX988_RS19995	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
FX988_RS20000	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FX988_RS20005	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FX988_RS20010	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FX988_RS20025	COG0656	L-ascorbic acid biosynthetic process
FX988_RS20035	COG2855	membrane
FX988_RS20050	COG1309	transcriptional regulator
FX988_RS20060	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FX988_RS20070	COG0789	Transcriptional regulator
FX988_RS20085	COG4771	TonB-dependent receptor
FX988_RS20095	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FX988_RS20100	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
FX988_RS20120	COG3706	GGDEF domain
FX988_RS20160	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FX988_RS20165	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FX988_RS20215	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FX988_RS20245	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FX988_RS20250	COG1522	sequence-specific DNA binding
FX988_RS20260	COG1280	lysine exporter protein (LysE YggA)
FX988_RS20280	COG0436	Aminotransferase
FX988_RS20285	COG4771	TonB-dependent receptor
FX988_RS20295	COG4558	Periplasmic binding protein
FX988_RS20300	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FX988_RS20345	COG3093	addiction module antidote protein HigA
FX988_RS20360	COG2161	toxin-antitoxin pair type II binding
FX988_RS20365	COG4115	mRNA cleavage
FX988_RS20395	COG1012	belongs to the aldehyde dehydrogenase family
FX988_RS20410	COG2188	Transcriptional regulator
FX988_RS20425	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
FX988_RS20430	COG0154	amidase activity
FX988_RS20480	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FX988_RS20500	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FX988_RS20515	COG2130	NADP-dependent
FX988_RS20525	COG4771	TonB-dependent receptor
FX988_RS20545	COG1024	Enoyl-CoA hydratase
FX988_RS20545	COG1250	3-hydroxyacyl-CoA dehydrogenase
FX988_RS20580	COG1335	isochorismatase
FX988_RS20590	COG2226	methyltransferase
FX988_RS20620	COG1560	Kdo2-lipid A biosynthetic process
FX988_RS20630	COG1028	Short-chain dehydrogenase reductase Sdr
FX988_RS20640	COG2301	Belongs to the HpcH HpaI aldolase family
FX988_RS20655	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FX988_RS20690	COG0583	DNA-binding transcription factor activity
FX988_RS20725	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FX988_RS20745	COG0454	-acetyltransferase
FX988_RS20750	COG3119	arylsulfatase activity
FX988_RS20765	COG1609	Transcriptional regulator
FX988_RS20770	COG0673	inositol 2-dehydrogenase activity
FX988_RS20780	COG2211	Major facilitator Superfamily
FX988_RS20810	COG2515	1-aminocyclopropane-1-carboxylate deaminase
FX988_RS20825	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FX988_RS20850	COG0583	DNA-binding transcription factor activity
FX988_RS20875	COG0708	Exodeoxyribonuclease III
FX988_RS20885	COG4948	Mandelate Racemase Muconate Lactonizing
FX988_RS20890	COG2271	Major facilitator Superfamily
FX988_RS20900	COG0800	Aldolase
FX988_RS20910	COG3386	PFAM SMP-30 Gluconolaconase
FX988_RS20920	COG0604	alcohol dehydrogenase
FX988_RS20925	COG1309	transcriptional regulator
FX988_RS20950	COG5006	permease, DMT superfamily
FX988_RS20960	COG0456	acetyltransferase
FX988_RS20965	COG3038	cytochrome b561
FX988_RS20975	COG1278	Cold shock
FX988_RS20985	COG4667	esterase of the alpha-beta hydrolase superfamily
FX988_RS21010	COG0805	protein transport
FX988_RS21055	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FX988_RS21080	COG1309	transcriptional regulator
FX988_RS21085	COG1012	belongs to the aldehyde dehydrogenase family
FX988_RS21125	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FX988_RS21130	COG2867	negative regulation of translational initiation
FX988_RS21135	COG2914	Belongs to the UPF0125 (RnfH) family
FX988_RS21145	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
FX988_RS21150	COG0574	Belongs to the PEP-utilizing enzyme family
FX988_RS21150	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FX988_RS21160	COG0247	lactate metabolic process
FX988_RS21160	COG0277	FAD linked oxidase domain protein
FX988_RS21205	COG3209	COG3209 Rhs family protein
FX988_RS21235	COG3550	peptidyl-serine autophosphorylation
FX988_RS21275	COG2199	diguanylate cyclase activity
FX988_RS21275	COG2200	EAL domain
FX988_RS21275	COG2202	Pas domain
FX988_RS21305	COG4974	Belongs to the 'phage' integrase family
FX988_RS21350	COG4974	Belongs to the 'phage' integrase family
FX988_RS21400	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FX988_RS21520	COG1192	Involved in chromosome partitioning
FX988_RS21550	COG3209	COG3209 Rhs family protein
FX988_RS21590	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP