locus-tag	class	description
DM447_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DM447_RS00010	COG0592	DNA-directed DNA polymerase activity
DM447_RS00015	COG2501	S4 domain
DM447_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DM447_RS00030	COG0187	DNA topoisomerase II activity
DM447_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DM447_RS00040	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
DM447_RS00050	COG0516	GMP reductase activity
DM447_RS00050	COG0517	IMP dehydrogenase activity
DM447_RS00070	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DM447_RS00080	COG3842	ATPase activity
DM447_RS00090	COG0395	ABC-type sugar transport system, permease component
DM447_RS00095	COG1653	transport
DM447_RS00110	COG1428	Deoxynucleoside kinase
DM447_RS00115	COG1428	Deoxynucleoside kinase
DM447_RS00120	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
DM447_RS00140	COG0697	spore germination
DM447_RS00150	COG0693	protein deglycase activity
DM447_RS00155	COG3858	chitin binding
DM447_RS00155	COG1388	LysM domain
DM447_RS00170	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DM447_RS00175	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DM447_RS00180	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DM447_RS00210	COG0563	adenylate kinase activity
DM447_RS00220	COG1982	Orn Lys Arg decarboxylase major
DM447_RS00225	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DM447_RS00230	COG3870	Protein conserved in bacteria
DM447_RS00235	COG1728	Protein conserved in bacteria
DM447_RS00240	COG0470	DNA polymerase III
DM447_RS00245	COG1774	PSP1 C-terminal conserved region
DM447_RS00250	COG4467	Involved in initiation control of chromosome replication
DM447_RS00255	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
DM447_RS00260	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DM447_RS00265	COG2002	toxin-antitoxin pair type II binding
DM447_RS00275	COG0084	hydrolase, TatD family'
DM447_RS00280	COG3584	3D domain protein
DM447_RS00280	COG3583	domain protein
DM447_RS00290	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DM447_RS00300	COG4466	Protein conserved in bacteria
DM447_RS00310	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DM447_RS00315	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DM447_RS00320	COG2088	sporulation resulting in formation of a cellular spore
DM447_RS00325	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DM447_RS00335	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DM447_RS00345	COG0193	aminoacyl-tRNA hydrolase activity
DM447_RS00355	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DM447_RS00360	COG2002	toxin-antitoxin pair type II binding
DM447_RS00365	COG3711	transcriptional antiterminator
DM447_RS00370	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DM447_RS00370	COG2190	(PTS) system
DM447_RS00370	COG1263	PTS System
DM447_RS00375	COG2244	polysaccharide biosynthetic process
DM447_RS00380	COG3956	TIGRFAM MazG family protein
DM447_RS00385	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
DM447_RS00405	COG1098	S1 RNA binding domain
DM447_RS00415	COG1937	Protein conserved in bacteria
DM447_RS00420	COG2217	Heavy metal translocating P-type atpase
DM447_RS00425	COG2608	mercury ion transmembrane transporter activity
DM447_RS00435	COG1846	Transcriptional regulator
DM447_RS00445	COG1132	(ABC) transporter
DM447_RS00450	COG2814	Major facilitator Superfamily
DM447_RS00455	COG1028	Short-chain dehydrogenase reductase Sdr
DM447_RS00460	COG0840	transmembrane signaling receptor activity
DM447_RS00470	COG0142	geranyltranstransferase activity
DM447_RS00515	COG0406	alpha-ribazole phosphatase activity
DM447_RS00520	COG2208	phosphoserine phosphatase activity
DM447_RS00525	COG2304	oxidoreductase activity
DM447_RS00530	COG0515	serine threonine protein kinase
DM447_RS00535	COG0037	tRNA processing
DM447_RS00540	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
DM447_RS00545	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DM447_RS00555	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
DM447_RS00560	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DM447_RS00565	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DM447_RS00570	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DM447_RS00575	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DM447_RS00580	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DM447_RS00585	COG1396	sequence-specific DNA binding
DM447_RS00590	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DM447_RS00675	COG1285	pathogenesis
DM447_RS00685	COG3880	PFAM UvrB UvrC protein
DM447_RS00690	COG3869	Catalyzes the specific phosphorylation of arginine residues in
DM447_RS00695	COG0542	response to heat
DM447_RS00700	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
DM447_RS00705	COG4956	integral membrane protein (PIN domain superfamily)
DM447_RS00710	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DM447_RS00715	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DM447_RS00720	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DM447_RS00725	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
DM447_RS00730	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DM447_RS00735	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DM447_RS00740	COG1045	serine acetyltransferase
DM447_RS00745	COG0215	cysteine-tRNA ligase activity
DM447_RS00755	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DM447_RS00760	COG3688	RNA-binding protein containing a PIN domain
DM447_RS00770	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DM447_RS00775	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DM447_RS00780	COG0250	Participates in transcription elongation, termination and antitermination
DM447_RS00785	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DM447_RS00790	COG0081	regulation of translation
DM447_RS00795	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DM447_RS00800	COG0222	ribosome binding
DM447_RS00805	COG2813	Specifically methylates the guanine in position
DM447_RS00810	COG0085	RNA polymerase activity
DM447_RS00815	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DM447_RS00820	COG1358	cellular component organization or biogenesis
DM447_RS00825	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DM447_RS00830	COG0049	tRNA binding
DM447_RS00835	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DM447_RS00840	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DM447_RS00845	COG4213	ABC transporter substrate-binding protein
DM447_RS00850	COG0840	transmembrane signaling receptor activity
DM447_RS00855	COG0051	transcription antitermination factor activity, RNA binding
DM447_RS00860	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DM447_RS00865	COG0088	Forms part of the polypeptide exit tunnel
DM447_RS00870	COG0089	rRNA binding
DM447_RS00875	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DM447_RS00880	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DM447_RS00885	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DM447_RS00890	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DM447_RS00895	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DM447_RS00900	COG0255	Belongs to the universal ribosomal protein uL29 family
DM447_RS00905	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DM447_RS00910	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DM447_RS00915	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DM447_RS00920	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DM447_RS00925	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DM447_RS00930	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DM447_RS00935	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DM447_RS00940	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DM447_RS00945	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DM447_RS00950	COG1841	ribosomal large subunit assembly
DM447_RS00955	COG0200	Binds to the 23S rRNA
DM447_RS00960	COG0201	protein transport
DM447_RS00965	COG0563	adenylate kinase activity
DM447_RS00970	COG2163	COG2163 Ribosomal protein L14E L6E L27E
DM447_RS00975	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DM447_RS00980	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DM447_RS00985	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DM447_RS00990	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DM447_RS00995	COG0202	RNA polymerase activity
DM447_RS01000	COG0203	ribosomal protein L17
DM447_RS01005	COG1122	ATPase activity
DM447_RS01010	COG1122	ATPase activity
DM447_RS01015	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
DM447_RS01020	COG0101	tRNA pseudouridine synthase activity
DM447_RS01025	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DM447_RS01030	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DM447_RS01035	COG1064	alcohol dehydrogenase
DM447_RS01040	COG0860	N-Acetylmuramoyl-L-alanine amidase
DM447_RS01045	COG0489	protein tyrosine kinase activity
DM447_RS01055	COG0726	polysaccharide deacetylase
DM447_RS01135	COG1595	DNA-templated transcription, initiation
DM447_RS01140	COG5662	AntiSigma factor
DM447_RS01145	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
DM447_RS01150	COG4856	YbbR-like protein
DM447_RS01155	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DM447_RS01170	COG5002	protein histidine kinase activity
DM447_RS01175	COG0745	RESPONSE REGULATOR receiver
DM447_RS01180	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DM447_RS01225	COG1612	heme a metabolic process
DM447_RS01245	COG4221	oxidoreductase activity
DM447_RS01260	COG3237	CsbD-like
DM447_RS01270	COG0346	lactoylglutathione lyase activity
DM447_RS01280	COG3711	transcriptional antiterminator
DM447_RS01295	COG2207	Transcriptional regulator
DM447_RS01300	COG4592	Periplasmic binding protein
DM447_RS01305	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DM447_RS01310	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DM447_RS01325	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DM447_RS01335	COG1595	DNA-templated transcription, initiation
DM447_RS01355	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DM447_RS01360	COG4876	unkown
DM447_RS01365	COG2910	NAD(P)H-binding
DM447_RS01370	COG3239	Fatty acid desaturase
DM447_RS01375	COG4585	Histidine kinase
DM447_RS01380	COG2197	response regulator
DM447_RS01395	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
DM447_RS01420	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DM447_RS01425	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DM447_RS01430	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DM447_RS01435	COG0492	ferredoxin-NADP+ reductase activity
DM447_RS01440	COG0346	lactoylglutathione lyase activity
DM447_RS01445	COG2364	Membrane
DM447_RS01455	COG4585	Histidine kinase
DM447_RS01460	COG2197	response regulator
DM447_RS01465	COG1131	(ABC) transporter
DM447_RS01495	COG1131	(ABC) transporter
DM447_RS01520	COG0371	Dehydrogenase
DM447_RS01535	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DM447_RS01545	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
DM447_RS01550	COG1418	mRNA catabolic process
DM447_RS01555	COG1595	DNA-templated transcription, initiation
DM447_RS01575	COG2195	Cleaves the N-terminal amino acid of tripeptides
DM447_RS01595	COG1562	ergosterol biosynthetic process
DM447_RS01610	COG0463	Glycosyl transferase, family 2
DM447_RS01620	COG1304	FMN binding
DM447_RS01630	COG0492	ferredoxin-NADP+ reductase activity
DM447_RS01635	COG1876	peptidase activity
DM447_RS01640	COG0129	dihydroxy-acid dehydratase activity
DM447_RS01645	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DM447_RS01655	COG4120	Belongs to the binding-protein-dependent transport system permease family
DM447_RS01665	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DM447_RS01670	COG5506	Protein of unknown function (DUF1694)
DM447_RS01675	COG1917	Cupin 2, conserved barrel domain protein
DM447_RS01680	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DM447_RS01685	COG0456	acetyltransferase
DM447_RS01695	COG2094	Belongs to the DNA glycosylase MPG family
DM447_RS01700	COG0753	catalase activity
DM447_RS01705	COG1119	ATPase activity
DM447_RS01725	COG0457	Tetratricopeptide repeat
DM447_RS01725	COG0463	Glycosyl transferase, family 2
DM447_RS01735	COG1045	serine acetyltransferase
DM447_RS01740	COG0673	inositol 2-dehydrogenase activity
DM447_RS01780	COG0741	lytic transglycosylase activity
DM447_RS01780	COG0791	NLP P60 protein
DM447_RS01795	COG2746	aminoglycoside 3-N-acetyltransferase activity
DM447_RS01800	COG1028	Short-chain dehydrogenase reductase Sdr
DM447_RS01805	COG1454	alcohol dehydrogenase
DM447_RS01805	COG1012	belongs to the aldehyde dehydrogenase family
DM447_RS01820	COG3871	stress protein (general stress protein 26)
DM447_RS01825	COG1979	alcohol dehydrogenase
DM447_RS01830	COG1028	Short-chain dehydrogenase reductase Sdr
DM447_RS01835	COG1309	transcriptional regulator
DM447_RS01840	COG2814	Major facilitator Superfamily
DM447_RS01845	COG1882	Formate acetyltransferase
DM447_RS01850	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DM447_RS01855	COG1764	response to oxidative stress
DM447_RS01860	COG0706	membrane insertase activity
DM447_RS01870	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DM447_RS01875	COG2268	Band 7 protein
DM447_RS01885	COG0716	FMN binding
DM447_RS01895	COG2807	transmembrane transport
DM447_RS01910	COG1533	DNA photolyase activity
DM447_RS01915	COG1012	belongs to the aldehyde dehydrogenase family
DM447_RS01920	COG1510	regulation of RNA biosynthetic process
DM447_RS01925	COG2113	Glycine betaine
DM447_RS01935	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
DM447_RS01940	COG0352	thiamine-phosphate diphosphorylase activity
DM447_RS01945	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DM447_RS01955	COG0693	protein deglycase activity
DM447_RS01960	COG2839	Protein conserved in bacteria
DM447_RS01965	COG0351	phosphomethylpyrimidine kinase
DM447_RS01970	COG0004	ammonium transporteR
DM447_RS01975	COG0347	Belongs to the P(II) protein family
DM447_RS01980	COG1131	(ABC) transporter
DM447_RS01985	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
DM447_RS01995	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DM447_RS02000	COG0436	Aminotransferase
DM447_RS02005	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DM447_RS02010	COG2011	ABC-type metal ion transport system permease component
DM447_RS02015	COG1464	Belongs to the NlpA lipoprotein family
DM447_RS02020	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DM447_RS02045	COG1181	Belongs to the D-alanine--D-alanine ligase family
DM447_RS02075	COG0137	argininosuccinate synthase activity
DM447_RS02080	COG0165	Argininosuccinate lyase
DM447_RS02085	COG0505	Belongs to the CarA family
DM447_RS02090	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DM447_RS02095	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DM447_RS02100	COG1012	belongs to the aldehyde dehydrogenase family
DM447_RS02105	COG1335	isochorismatase
DM447_RS02110	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DM447_RS02115	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DM447_RS02130	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DM447_RS02130	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DM447_RS02135	COG0307	riboflavin synthase, alpha
DM447_RS02140	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DM447_RS02140	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DM447_RS02145	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DM447_RS02150	COG0386	Belongs to the glutathione peroxidase family
DM447_RS02155	COG1054	Belongs to the UPF0176 family
DM447_RS02160	COG1278	Cold shock
DM447_RS02170	COG2084	Dehydrogenase
DM447_RS02175	COG2153	protein acetylation
DM447_RS02180	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DM447_RS02185	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
DM447_RS02190	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DM447_RS02195	COG0745	RESPONSE REGULATOR receiver
DM447_RS02200	COG3850	Histidine kinase
DM447_RS02200	COG5002	protein histidine kinase activity
DM447_RS02205	COG1217	gtp-binding protein TYPA
DM447_RS02235	COG2843	Capsule synthesis protein
DM447_RS02245	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DM447_RS02255	COG4152	abc transporter atp-binding protein
DM447_RS02265	COG1846	Transcriptional regulator
DM447_RS02270	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DM447_RS02290	COG0513	Belongs to the DEAD box helicase family
DM447_RS02295	COG0705	Rhomboid family
DM447_RS02300	COG0736	holo-[acyl-carrier-protein] synthase activity
DM447_RS02305	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DM447_RS02305	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DM447_RS02310	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
DM447_RS02320	COG0864	Transcriptional regulator
DM447_RS02325	COG2337	Toxic component of a toxin-antitoxin (TA) module
DM447_RS02330	COG1366	Belongs to the anti-sigma-factor antagonist family
DM447_RS02335	COG1366	Belongs to the anti-sigma-factor antagonist family
DM447_RS02340	COG2172	sigma factor antagonist activity
DM447_RS02345	COG2208	phosphoserine phosphatase activity
DM447_RS02350	COG1366	Belongs to the anti-sigma-factor antagonist family
DM447_RS02355	COG2172	sigma factor antagonist activity
DM447_RS02360	COG1191	sigma factor activity
DM447_RS02365	COG2208	phosphoserine phosphatase activity
DM447_RS02370	COG2183	response to ionizing radiation
DM447_RS02380	COG3091	SprT-like family
DM447_RS02465	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
DM447_RS02470	COG0802	atpase or kinase
DM447_RS02475	COG1214	PFAM Peptidase M22, glycoprotease
DM447_RS02480	COG0456	acetyltransferase
DM447_RS02485	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DM447_RS02490	COG0488	(ABC) transporter
DM447_RS02495	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
DM447_RS02505	COG1266	CAAX protease self-immunity
DM447_RS02510	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DM447_RS02515	COG0459	protein refolding
DM447_RS02550	COG1131	(ABC) transporter
DM447_RS02620	COG3177	Filamentation induced by cAMP protein fic
DM447_RS02630	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
DM447_RS02645	COG0641	radical SAM
DM447_RS02650	COG0583	DNA-binding transcription factor activity
DM447_RS02660	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DM447_RS02665	COG1737	Transcriptional regulator
DM447_RS02680	COG2723	6-phospho-beta-galactosidase activity
DM447_RS02685	COG1263	PTS System
DM447_RS02685	COG2190	(PTS) system
DM447_RS02685	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DM447_RS02690	COG0583	DNA-binding transcription factor activity
DM447_RS02695	COG0163	prenyltransferase activity
DM447_RS02705	COG1811	Na channel or pump
DM447_RS02710	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
DM447_RS02715	COG2190	(PTS) system
DM447_RS02715	COG1263	PTS System
DM447_RS02715	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DM447_RS02720	COG2723	6-phospho-beta-galactosidase activity
DM447_RS02725	COG3711	transcriptional antiterminator
DM447_RS02730	COG0371	Dehydrogenase
DM447_RS02735	COG2197	response regulator
DM447_RS02740	COG0154	amidase activity
DM447_RS02745	COG2271	Major facilitator Superfamily
DM447_RS02760	COG1113	amino acid transport
DM447_RS02765	COG1574	metal-dependent hydrolase with the TIM-barrel fold
DM447_RS02800	COG1472	Belongs to the glycosyl hydrolase 3 family
DM447_RS02815	COG1216	Glycosyl transferase, family 2
DM447_RS02830	COG0840	transmembrane signaling receptor activity
DM447_RS02835	COG3706	GGDEF domain
DM447_RS02840	COG4122	O-methyltransferase activity
DM447_RS02860	COG1902	pentaerythritol trinitrate reductase activity
DM447_RS02875	COG0800	Aldolase
DM447_RS02880	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DM447_RS02885	COG1366	Belongs to the anti-sigma-factor antagonist family
DM447_RS02885	COG2202	Pas domain
DM447_RS02895	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DM447_RS02900	COG0714	Associated with various cellular activities
DM447_RS02905	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
DM447_RS02910	COG1305	Transglutaminase-like
DM447_RS02915	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DM447_RS02915	COG0519	Catalyzes the synthesis of GMP from XMP
DM447_RS02920	COG2252	PERMEase
DM447_RS02930	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
DM447_RS02940	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DM447_RS02945	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
DM447_RS02950	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DM447_RS02955	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DM447_RS02960	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DM447_RS02965	COG0047	phosphoribosylformylglycinamidine synthase activity
DM447_RS02970	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DM447_RS02975	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
DM447_RS02980	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DM447_RS02985	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DM447_RS02990	COG0138	bifunctional purine biosynthesis protein purh
DM447_RS02995	COG0151	Belongs to the GarS family
DM447_RS03000	COG4555	ABC transporter
DM447_RS03015	COG0840	transmembrane signaling receptor activity
DM447_RS03020	COG1486	melibiose metabolic process
DM447_RS03025	COG0521	Mo-molybdopterin cofactor biosynthetic process
DM447_RS03035	COG0725	ABC transporter, periplasmic molybdate-binding protein
DM447_RS03040	COG4149	molybdate abc transporter
DM447_RS03045	COG1470	cell adhesion involved in biofilm formation
DM447_RS03050	COG4496	protein, YerC YecD
DM447_RS03055	COG0673	inositol 2-dehydrogenase activity
DM447_RS03060	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
DM447_RS03065	COG0210	DNA helicase
DM447_RS03070	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DM447_RS03075	COG4851	CamS sex pheromone cAM373 precursor
DM447_RS03080	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DM447_RS03085	COG0154	amidase activity
DM447_RS03090	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DM447_RS03095	COG1597	lipid kinase activity
DM447_RS03100	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DM447_RS03115	COG0583	DNA-binding transcription factor activity
DM447_RS03120	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DM447_RS03140	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
DM447_RS03145	COG0406	alpha-ribazole phosphatase activity
DM447_RS03155	COG1619	proteins homologs of microcin C7 resistance protein MccF
DM447_RS03170	COG0641	radical SAM
DM447_RS03175	COG1472	Belongs to the glycosyl hydrolase 3 family
DM447_RS03195	COG3119	arylsulfatase activity
DM447_RS03205	COG2207	Transcriptional regulator
DM447_RS03215	COG0562	UDP-galactopyranose mutase
DM447_RS03230	COG1472	Belongs to the glycosyl hydrolase 3 family
DM447_RS03240	COG0463	Glycosyl transferase, family 2
DM447_RS03245	COG1472	Belongs to the glycosyl hydrolase 3 family
DM447_RS03255	COG2832	Protein of unknown function (DUF454)
DM447_RS03260	COG2045	Belongs to the ComB family
DM447_RS03265	COG1809	phosphosulfolactate synthase activity
DM447_RS03290	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
DM447_RS03295	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DM447_RS03305	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DM447_RS03310	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DM447_RS03335	COG0167	dihydroorotate dehydrogenase activity
DM447_RS03350	COG3835	regulator
DM447_RS03355	COG1012	belongs to the aldehyde dehydrogenase family
DM447_RS03360	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DM447_RS03365	COG0686	Belongs to the AlaDH PNT family
DM447_RS03370	COG4895	conserved protein (DUF2196)
DM447_RS03410	COG0714	Associated with various cellular activities
DM447_RS03430	COG2848	UPF0210 protein
DM447_RS03440	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
DM447_RS03445	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DM447_RS03450	COG0647	UMP catabolic process
DM447_RS03455	COG4443	Transcriptional Coactivator p15 (PC4)
DM447_RS03460	COG1077	Cell shape determining protein MreB Mrl
DM447_RS03465	COG2258	MOSC domain
DM447_RS03475	COG1115	amino acid carrier protein
DM447_RS03480	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DM447_RS03490	COG1295	ribonuclease BN
DM447_RS03495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DM447_RS03500	COG0765	amino acid transport
DM447_RS03505	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DM447_RS03510	COG0477	Major facilitator Superfamily
DM447_RS03520	COG2364	Membrane
DM447_RS03530	COG0668	transmembrane transport
DM447_RS03535	COG2056	Na+-H+ antiporter family
DM447_RS03545	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
DM447_RS03550	COG0248	Ppx GppA phosphatase
DM447_RS03560	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DM447_RS03565	COG0542	response to heat
DM447_RS03570	COG0658	competence protein
DM447_RS03570	COG2333	competence protein COMEC
DM447_RS03575	COG1834	amidinotransferase
DM447_RS03580	COG2323	membrane
DM447_RS03585	COG2188	Transcriptional regulator
DM447_RS03590	COG1131	(ABC) transporter
DM447_RS03605	COG1131	(ABC) transporter
DM447_RS03620	COG0038	chloride channel
DM447_RS03625	COG2323	membrane
DM447_RS03635	COG3858	chitin binding
DM447_RS03650	COG0716	FMN binding
DM447_RS03655	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DM447_RS03660	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DM447_RS03680	COG1090	epimerase
DM447_RS03685	COG2137	regulation of response to DNA damage stimulus
DM447_RS03690	COG0561	phosphatase activity
DM447_RS03705	COG1988	membrane-bound metal-dependent
DM447_RS03710	COG1194	a g-specific adenine glycosylase
DM447_RS03720	COG3557	Belongs to the UPF0374 family
DM447_RS03725	COG1132	(ABC) transporter
DM447_RS03730	COG4129	membrane
DM447_RS03735	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DM447_RS03745	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DM447_RS03755	COG2096	Adenosyltransferase
DM447_RS03760	COG0735	belongs to the Fur family
DM447_RS03855	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DM447_RS03860	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
DM447_RS03865	COG1028	Short-chain dehydrogenase reductase Sdr
DM447_RS03870	COG0246	Mannitol dehydrogenase
DM447_RS03875	COG2721	sulfolactate sulfo-lyase activity
DM447_RS03880	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
DM447_RS03895	COG2207	Transcriptional regulator
DM447_RS03900	COG5578	integral membrane protein
DM447_RS03905	COG1653	transport
DM447_RS03930	COG4209	transmembrane transport
DM447_RS03935	COG0395	ABC-type sugar transport system, permease component
DM447_RS03945	COG0477	Major facilitator Superfamily
DM447_RS03965	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
DM447_RS03975	COG2755	lipolytic protein G-D-S-L family
DM447_RS03980	COG1082	Xylose isomerase domain protein TIM barrel
DM447_RS03990	COG1028	Short-chain dehydrogenase reductase Sdr
DM447_RS03995	COG1070	Carbohydrate kinase
DM447_RS04000	COG1691	(AIR) carboxylase
DM447_RS04005	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
DM447_RS04010	COG1606	tRNA processing
DM447_RS04015	COG1609	Transcriptional regulator
DM447_RS04025	COG1904	glucuronate isomerase
DM447_RS04030	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DM447_RS04035	COG2066	Belongs to the glutaminase family
DM447_RS04050	COG1970	mechanosensitive ion channel activity
DM447_RS04055	COG1733	regulation of RNA biosynthetic process
DM447_RS04065	COG0431	NADPH-dependent FMN reductase
DM447_RS04085	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DM447_RS04095	COG1132	(ABC) transporter
DM447_RS04100	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DM447_RS04105	COG0384	phenazine biosynthesis protein PhzF
DM447_RS04110	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DM447_RS04115	COG5001	Diguanylate cyclase
DM447_RS04130	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DM447_RS04140	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DM447_RS04145	COG1321	iron dependent repressor
DM447_RS04145	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DM447_RS04150	COG1121	(ABC) transporter
DM447_RS04155	COG0803	Belongs to the bacterial solute-binding protein 9 family
DM447_RS04170	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DM447_RS04185	COG2766	serine protein kinase
DM447_RS04190	COG0567	Dehydrogenase, E1 component
DM447_RS04195	COG0508	dehydrogenase complex catalyzes the overall conversion of
DM447_RS04200	COG2718	Belongs to the UPF0229 family
DM447_RS04215	COG1966	Carbon starvation protein
DM447_RS04240	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DM447_RS04250	COG0288	reversible hydration of carbon dioxide
DM447_RS04255	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DM447_RS04260	COG1191	sigma factor activity
DM447_RS04280	COG1854	S-ribosylhomocysteine lyase activity
DM447_RS04295	COG1937	Protein conserved in bacteria
DM447_RS04300	COG2719	SpoVR family
DM447_RS04305	COG0640	Transcriptional regulator
DM447_RS04320	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
DM447_RS04330	COG2199	diguanylate cyclase activity
DM447_RS04330	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
DM447_RS04340	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DM447_RS04345	COG1845	cytochrome c oxidase, subunit III
DM447_RS04360	COG0626	cystathionine gamma-synthase activity
DM447_RS04390	COG0024	Methionine aminopeptidase
DM447_RS04400	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
DM447_RS04410	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DM447_RS04415	COG2814	Major facilitator Superfamily
DM447_RS04425	COG1876	peptidase activity
DM447_RS04430	COG0114	fumarate hydratase activity
DM447_RS04445	COG3842	ATPase activity
DM447_RS04450	COG2508	Transcriptional regulator
DM447_RS04455	COG4399	Belongs to the UPF0754 family
DM447_RS04460	COG3679	Belongs to the UPF0342 family
DM447_RS04465	COG4152	abc transporter atp-binding protein
DM447_RS04470	COG1668	transmembrane transport
DM447_RS04475	COG0420	3'-5' exonuclease activity
DM447_RS04480	COG4717	serine-type aminopeptidase activity
DM447_RS04485	COG1510	regulation of RNA biosynthetic process
DM447_RS04495	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DM447_RS04510	COG1510	regulation of RNA biosynthetic process
DM447_RS04515	COG0517	IMP dehydrogenase activity
DM447_RS04515	COG4175	Glycine betaine
DM447_RS04535	COG4980	gas vesicle protein
DM447_RS04545	COG0537	adenosine 5'-monophosphoramidase activity
DM447_RS04550	COG1131	(ABC) transporter
DM447_RS04555	COG4473	ABC transporter
DM447_RS04560	COG1473	amidohydrolase
DM447_RS04580	COG4585	Histidine kinase
DM447_RS04585	COG2197	response regulator
DM447_RS04595	COG2329	Antibiotic biosynthesis monooxygenase
DM447_RS04600	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DM447_RS04605	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
DM447_RS04610	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
DM447_RS04615	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
DM447_RS04620	COG1234	tRNA 3'-trailer cleavage
DM447_RS04625	COG0095	Lipoate-protein ligase
DM447_RS04630	COG0501	Belongs to the peptidase M48B family
DM447_RS04650	COG0398	Pfam SNARE associated Golgi protein
DM447_RS04660	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
DM447_RS04665	COG1074	ATP-dependent DNA helicase activity
DM447_RS04700	COG2311	Membrane
DM447_RS04710	COG0367	asparagine synthase
DM447_RS04715	COG0534	Mate efflux family protein
DM447_RS04720	COG1028	Short-chain dehydrogenase reductase Sdr
DM447_RS04725	COG1307	EDD domain protein, DegV family
DM447_RS04730	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DM447_RS04740	COG3706	GGDEF domain
DM447_RS04755	COG0561	phosphatase activity
DM447_RS04760	COG1073	alpha beta
DM447_RS04765	COG2151	metal-sulfur cluster biosynthetic enzyme
DM447_RS04770	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DM447_RS04775	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DM447_RS04800	COG1744	ABC transporter substrate-binding protein PnrA-like
DM447_RS04805	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DM447_RS04810	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DM447_RS04825	COG0180	Tryptophanyl-tRNA synthetase
DM447_RS04835	COG4166	transmembrane transport
DM447_RS04840	COG0601	transmembrane transport
DM447_RS04845	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DM447_RS04850	COG0444	Belongs to the ABC transporter superfamily
DM447_RS04855	COG4608	Belongs to the ABC transporter superfamily
DM447_RS04865	COG0456	acetyltransferase
DM447_RS04870	COG1393	Belongs to the ArsC family
DM447_RS04875	COG4862	establishment of competence for transformation
DM447_RS04880	COG4469	Competence protein
DM447_RS04885	COG1164	Oligoendopeptidase f
DM447_RS04890	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DM447_RS04895	COG2346	COG2346, Truncated hemoglobins
DM447_RS04900	COG4116	CYTH
DM447_RS04905	COG2357	RelA SpoT domain protein
DM447_RS04910	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DM447_RS04915	COG0564	pseudouridine synthase activity
DM447_RS04920	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DM447_RS04925	COG0772	Belongs to the SEDS family
DM447_RS04930	COG2239	Acts as a magnesium transporter
DM447_RS04935	COG0569	domain protein
DM447_RS04935	COG0475	glutathione-regulated potassium exporter activity
DM447_RS04965	COG2323	membrane
DM447_RS04970	COG2153	protein acetylation
DM447_RS04975	COG0840	transmembrane signaling receptor activity
DM447_RS04980	COG3773	Cell wall hydrolase
DM447_RS04990	COG2329	Antibiotic biosynthesis monooxygenase
DM447_RS05000	COG1733	regulation of RNA biosynthetic process
DM447_RS05005	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
DM447_RS05010	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
DM447_RS05015	COG0564	pseudouridine synthase activity
DM447_RS05020	COG0166	Belongs to the GPI family
DM447_RS05035	COG1098	S1 RNA binding domain
DM447_RS05040	COG0488	(ABC) transporter
DM447_RS05050	COG2202	Pas domain
DM447_RS05050	COG1366	Belongs to the anti-sigma-factor antagonist family
DM447_RS05055	COG1316	TRANSCRIPTIONal
DM447_RS05115	COG4221	oxidoreductase activity
DM447_RS05120	COG2323	membrane
DM447_RS05135	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DM447_RS05140	COG1404	Belongs to the peptidase S8 family
DM447_RS05145	COG1363	Peptidase, m42
DM447_RS05155	COG1136	(ABC) transporter
DM447_RS05160	COG0577	efflux transmembrane transporter activity
DM447_RS05160	COG1136	(ABC) transporter
DM447_RS05165	COG0745	RESPONSE REGULATOR receiver
DM447_RS05170	COG5002	protein histidine kinase activity
DM447_RS05170	COG3850	Histidine kinase
DM447_RS05200	COG1078	dGTPase activity
DM447_RS05210	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DM447_RS05215	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DM447_RS05220	COG1525	nuclease
DM447_RS05225	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DM447_RS05230	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DM447_RS05240	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DM447_RS05250	COG0084	hydrolase, TatD family'
DM447_RS05265	COG0586	Pfam SNARE associated Golgi protein
DM447_RS05295	COG3507	Belongs to the glycosyl hydrolase 43 family
DM447_RS05310	COG0697	spore germination
DM447_RS05320	COG0531	amino acid
DM447_RS05370	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DM447_RS05375	COG0006	proline dipeptidase activity
DM447_RS05380	COG0653	protein targeting
DM447_RS05385	COG0640	Transcriptional regulator
DM447_RS05390	COG0798	PFAM Bile acid sodium symporter
DM447_RS05410	COG0446	pyridine nucleotide-disulphide oxidoreductase
DM447_RS05480	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DM447_RS05480	COG4499	WXG100 protein secretion system (Wss), protein YukC
DM447_RS05490	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DM447_RS05515	COG0488	(ABC) transporter
DM447_RS05520	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DM447_RS05525	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
DM447_RS05540	COG0640	Transcriptional regulator
DM447_RS05560	COG3142	Participates in the control of copper homeostasis
DM447_RS05585	COG3773	Cell wall hydrolase
DM447_RS05590	COG2723	6-phospho-beta-galactosidase activity
DM447_RS05605	COG3706	GGDEF domain
DM447_RS05615	COG1231	oxidoreductase activity
DM447_RS05630	COG3852	Histidine kinase
DM447_RS05660	COG1247	-acetyltransferase
DM447_RS05670	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
DM447_RS05680	COG0494	nUDIX hydrolase
DM447_RS05690	COG0813	purine-nucleoside phosphorylase activity
DM447_RS05750	COG1233	COG1233 Phytoene dehydrogenase and related
DM447_RS05760	COG0281	malic enzyme
DM447_RS05770	COG2378	regulation of single-species biofilm formation
DM447_RS05780	COG0519	Catalyzes the synthesis of GMP from XMP
DM447_RS05825	COG0628	permease
DM447_RS05845	COG0305	Participates in initiation and elongation during chromosome replication
DM447_RS05850	COG1525	nuclease
DM447_RS05870	COG0010	Belongs to the arginase family
DM447_RS05915	COG2207	Transcriptional regulator
DM447_RS05915	COG3708	Transcriptional regulator
DM447_RS05935	COG0657	acetylesterase activity
DM447_RS05940	COG1811	Na channel or pump
DM447_RS05945	COG3711	transcriptional antiterminator
DM447_RS05950	COG2190	(PTS) system
DM447_RS05950	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DM447_RS05950	COG1263	PTS System
DM447_RS05955	COG3394	polysaccharide catabolic process
DM447_RS05970	COG2190	(PTS) system
DM447_RS05970	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DM447_RS05970	COG1263	PTS System
DM447_RS06020	COG2378	regulation of single-species biofilm formation
DM447_RS06030	COG1902	pentaerythritol trinitrate reductase activity
DM447_RS06035	COG1522	sequence-specific DNA binding
DM447_RS06040	COG0583	DNA-binding transcription factor activity
DM447_RS06065	COG2182	Extracellular solute-binding protein
DM447_RS06070	COG1175	transmembrane transport
DM447_RS06075	COG3833	ABC-type maltose transport systems, permease component
DM447_RS06100	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DM447_RS06150	COG0406	alpha-ribazole phosphatase activity
DM447_RS06170	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
DM447_RS06170	COG0131	Imidazoleglycerol-phosphate dehydratase
DM447_RS06215	COG1247	-acetyltransferase
DM447_RS06280	COG1714	RDD family
DM447_RS06305	COG3152	Membrane
DM447_RS06310	COG1725	Transcriptional regulator
DM447_RS06315	COG1131	(ABC) transporter
DM447_RS06330	COG1595	DNA-templated transcription, initiation
DM447_RS06335	COG2267	carboxylic ester hydrolase activity
DM447_RS06355	COG2814	Major facilitator Superfamily
DM447_RS06370	COG3655	Transcriptional regulator
DM447_RS06375	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DM447_RS06425	COG0561	phosphatase activity
DM447_RS06450	COG0024	Methionine aminopeptidase
DM447_RS06455	COG0840	transmembrane signaling receptor activity
DM447_RS06455	COG3290	protein histidine kinase activity
DM447_RS06500	COG1846	Transcriptional regulator
DM447_RS06520	COG0456	acetyltransferase
DM447_RS06525	COG0456	acetyltransferase
DM447_RS06530	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DM447_RS06575	COG2816	NAD+ diphosphatase activity
DM447_RS06620	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
DM447_RS06620	COG0456	acetyltransferase
DM447_RS06640	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DM447_RS06650	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DM447_RS06655	COG0456	acetyltransferase
DM447_RS06660	COG2226	methyltransferase
DM447_RS06665	COG2318	DinB family
DM447_RS06675	COG1011	Hydrolase
DM447_RS06700	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
DM447_RS06725	COG4106	trans-aconitate 2-methyltransferase activity
DM447_RS06745	COG0671	phosphoesterase, PA-phosphatase related
DM447_RS06750	COG2323	membrane
DM447_RS06755	COG2323	membrane
DM447_RS06775	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DM447_RS06785	COG3226	Transcriptional regulator
DM447_RS06830	COG1051	belongs to the nudix hydrolase family
DM447_RS06835	COG4106	trans-aconitate 2-methyltransferase activity
DM447_RS06840	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DM447_RS06845	COG2226	methyltransferase
DM447_RS06850	COG1132	(ABC) transporter
DM447_RS06855	COG0745	RESPONSE REGULATOR receiver
DM447_RS06860	COG2205	protein histidine kinase activity
DM447_RS06865	COG1136	(ABC) transporter
DM447_RS06870	COG0577	efflux transmembrane transporter activity
DM447_RS06885	COG0791	NLP P60 protein
DM447_RS06885	COG1388	LysM domain
DM447_RS06895	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DM447_RS06895	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DM447_RS06895	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DM447_RS06900	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DM447_RS06905	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DM447_RS06925	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
DM447_RS06945	COG2199	diguanylate cyclase activity
DM447_RS06945	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
DM447_RS06965	COG2818	Glycosylase
DM447_RS06985	COG3906	Belongs to the UPF0473 family
DM447_RS07020	COG0745	RESPONSE REGULATOR receiver
DM447_RS07025	COG5002	protein histidine kinase activity
DM447_RS07040	COG1278	Cold shock
DM447_RS07055	COG1510	regulation of RNA biosynthetic process
DM447_RS07065	COG1174	glycine betaine transport
DM447_RS07075	COG1174	glycine betaine transport
DM447_RS07080	COG1473	amidohydrolase
DM447_RS07095	COG1408	metallophosphoesterase
DM447_RS07105	COG2329	Antibiotic biosynthesis monooxygenase
DM447_RS07120	COG1408	metallophosphoesterase
DM447_RS07145	COG0346	lactoylglutathione lyase activity
DM447_RS07160	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DM447_RS07175	COG0058	SHG alpha-glucan phosphorylase activity
DM447_RS07180	COG0297	glycogen (starch) synthase activity
DM447_RS07185	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DM447_RS07190	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DM447_RS07195	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DM447_RS07200	COG1523	belongs to the glycosyl hydrolase 13 family
DM447_RS07215	COG2200	EAL domain
DM447_RS07220	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
DM447_RS07225	COG3428	Bacterial PH domain
DM447_RS07230	COG3402	PFAM membrane-flanked domain
DM447_RS07245	COG2116	formate transmembrane transporter activity
DM447_RS07260	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DM447_RS07265	COG0840	transmembrane signaling receptor activity
DM447_RS07270	COG2111	Na H antiporter
DM447_RS07270	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DM447_RS07275	COG2111	Na H antiporter
DM447_RS07280	COG1006	Multisubunit Na H antiporter MnhC subunit
DM447_RS07285	COG0651	ATP synthesis coupled electron transport
DM447_RS07290	COG1863	multisubunit Na H antiporter MnhE subunit
DM447_RS07295	COG2212	antiporter activity
DM447_RS07300	COG1320	monovalent cation:proton antiporter activity
DM447_RS07310	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DM447_RS07315	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DM447_RS07315	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DM447_RS07320	COG0730	response to heat
DM447_RS07325	COG2210	Belongs to the sulfur carrier protein TusA family
DM447_RS07330	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DM447_RS07335	COG0425	Belongs to the sulfur carrier protein TusA family
DM447_RS07345	COG1288	antiporter activity
DM447_RS07355	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DM447_RS07360	COG0785	Cytochrome C biogenesis protein
DM447_RS07365	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DM447_RS07370	COG0783	Belongs to the Dps family
DM447_RS07380	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DM447_RS07390	COG0561	phosphatase activity
DM447_RS07395	COG3711	transcriptional antiterminator
DM447_RS07400	COG1263	PTS System
DM447_RS07400	COG2190	(PTS) system
DM447_RS07400	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DM447_RS07410	COG0561	phosphatase activity
DM447_RS07420	COG3507	Belongs to the glycosyl hydrolase 43 family
DM447_RS07445	COG0582	viral genome integration into host DNA
DM447_RS07465	COG1278	Cold shock
DM447_RS07470	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DM447_RS07485	COG0456	acetyltransferase
DM447_RS07505	COG1609	Transcriptional regulator
DM447_RS07515	COG0366	Alpha amylase catalytic
DM447_RS07520	COG0366	Alpha amylase catalytic
DM447_RS07535	COG1653	transport
DM447_RS07540	COG1501	Belongs to the glycosyl hydrolase 31 family
DM447_RS07545	COG2207	Transcriptional regulator
DM447_RS07545	COG1917	Cupin 2, conserved barrel domain protein
DM447_RS07550	COG2207	Transcriptional regulator
DM447_RS07550	COG4753	response regulator
DM447_RS07555	COG2972	Histidine kinase
DM447_RS07595	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
DM447_RS07620	COG1609	Transcriptional regulator
DM447_RS07625	COG0561	phosphatase activity
DM447_RS07630	COG1252	NADH dehydrogenase
DM447_RS07635	COG0217	transcriptional regulatory protein
DM447_RS07640	COG0667	Aldo Keto reductase
DM447_RS07660	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DM447_RS07665	COG0765	amino acid transport
DM447_RS07670	COG1126	abc transporter atp-binding protein
DM447_RS07680	COG2116	formate transmembrane transporter activity
DM447_RS07695	COG0714	Associated with various cellular activities
DM447_RS07710	COG0400	carboxylic ester hydrolase activity
DM447_RS07725	COG2706	6-phosphogluconolactonase activity
DM447_RS07735	COG1126	abc transporter atp-binding protein
DM447_RS07740	COG0765	amino acid transport
DM447_RS07745	COG4597	amino acid ABC transporter
DM447_RS07750	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DM447_RS07760	COG0066	3-isopropylmalate dehydratase activity
DM447_RS07765	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DM447_RS07770	COG0473	3-isopropylmalate dehydrogenase activity
DM447_RS07775	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DM447_RS07780	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DM447_RS07785	COG0440	acetolactate synthase activity
DM447_RS07790	COG0028	Belongs to the TPP enzyme family
DM447_RS07805	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DM447_RS07835	COG0604	alcohol dehydrogenase
DM447_RS07845	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DM447_RS07865	COG0778	Nitroreductase
DM447_RS07875	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DM447_RS07885	COG0681	Belongs to the peptidase S26 family
DM447_RS07895	COG0436	Aminotransferase
DM447_RS07905	COG4667	esterase of the alpha-beta hydrolase superfamily
DM447_RS07920	COG0517	IMP dehydrogenase activity
DM447_RS07925	COG2171	N-acyltransferase activity
DM447_RS07930	COG1473	amidohydrolase
DM447_RS07940	COG0668	transmembrane transport
DM447_RS07945	COG0450	alkyl hydroperoxide reductase
DM447_RS07950	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DM447_RS07955	COG1132	(ABC) transporter
DM447_RS07960	COG1132	(ABC) transporter
DM447_RS07970	COG0569	domain protein
DM447_RS07975	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DM447_RS07980	COG5503	Protein of unknown function (DUF1447)
DM447_RS08015	COG0726	polysaccharide deacetylase
DM447_RS08020	COG1982	Orn Lys Arg decarboxylase major
DM447_RS08025	COG4476	Belongs to the UPF0223 family
DM447_RS08030	COG4493	Belongs to the UPF0637 family
DM447_RS08035	COG0483	inositol monophosphate 1-phosphatase activity
DM447_RS08040	COG4896	Protein conserved in bacteria
DM447_RS08055	COG4838	Belongs to the UPF0358 family
DM447_RS08060	COG0772	Belongs to the SEDS family
DM447_RS08065	COG0109	protoheme IX farnesyltransferase activity
DM447_RS08080	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
DM447_RS08085	COG2340	Cysteine-rich secretory protein family
DM447_RS08100	COG3679	Belongs to the UPF0342 family
DM447_RS08105	COG4471	UPF0298 protein
DM447_RS08110	COG0742	ribosomal rna small subunit methyltransferase
DM447_RS08115	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DM447_RS08120	COG3314	Sporulation integral membrane protein YlbJ
DM447_RS08125	COG3480	Lon protease (S16) C-terminal proteolytic domain
DM447_RS08135	COG1323	Belongs to the UPF0348 family
DM447_RS08145	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DM447_RS08160	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
DM447_RS08165	COG2001	Belongs to the MraZ family
DM447_RS08170	COG0275	rRNA processing
DM447_RS08175	COG4839	cell division protein FtsL
DM447_RS08180	COG0768	penicillin binding
DM447_RS08185	COG0768	penicillin binding
DM447_RS08190	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DM447_RS08195	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DM447_RS08200	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DM447_RS08205	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DM447_RS08210	COG0772	Belongs to the SEDS family
DM447_RS08215	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DM447_RS08220	COG3879	Bacterial protein of unknown function (DUF881)
DM447_RS08225	COG3879	Bacterial protein of unknown function (DUF881)
DM447_RS08230	COG3856	small basic protein
DM447_RS08235	COG0849	cell division
DM447_RS08240	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DM447_RS08250	COG1191	sigma factor activity
DM447_RS08255	COG1191	sigma factor activity
DM447_RS08260	COG1873	PFAM PRC-barrel domain
DM447_RS08265	COG1496	oxidoreductase activity
DM447_RS08270	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DM447_RS08275	COG1799	cell septum assembly
DM447_RS08280	COG0762	integral membrane protein
DM447_RS08285	COG2302	S4 RNA-binding domain
DM447_RS08290	COG3599	regulation of cell shape
DM447_RS08295	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DM447_RS08315	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DM447_RS08320	COG0564	pseudouridine synthase activity
DM447_RS08330	COG2233	PERMEase
DM447_RS08335	COG0540	Belongs to the ATCase OTCase family
DM447_RS08340	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DM447_RS08345	COG0505	Belongs to the CarA family
DM447_RS08350	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DM447_RS08355	COG0543	2 iron, 2 sulfur cluster binding
DM447_RS08365	COG0284	orotidine-5'-phosphate decarboxylase activity
DM447_RS08370	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DM447_RS08395	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DM447_RS08405	COG1561	YicC-like family, N-terminal region
DM447_RS08410	COG2052	Domain of unknown function (DUF370)
DM447_RS08415	COG0194	GDP metabolic process
DM447_RS08420	COG1758	RNA polymerase activity
DM447_RS08425	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DM447_RS08430	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DM447_RS08435	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DM447_RS08440	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DM447_RS08440	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DM447_RS08445	COG0631	protein serine/threonine phosphatase activity
DM447_RS08450	COG2815	serine threonine protein kinase
DM447_RS08450	COG0515	serine threonine protein kinase
DM447_RS08455	COG1162	GTPase activity
DM447_RS08460	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DM447_RS08465	COG1564	THIamine pyrophosphokinase
DM447_RS08475	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DM447_RS08480	COG1302	Protein conserved in bacteria
DM447_RS08485	COG1461	Dihydroxyacetone kinase
DM447_RS08490	COG1760	l-serine dehydratase
DM447_RS08495	COG1760	l-serine dehydratase
DM447_RS08500	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DM447_RS08505	COG1349	DNA-binding transcription factor activity
DM447_RS08510	COG0416	fatty acid biosynthetic process
DM447_RS08515	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DM447_RS08520	COG1028	Short-chain dehydrogenase reductase Sdr
DM447_RS08525	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DM447_RS08535	COG0571	ribonuclease III activity
DM447_RS08540	COG4840	Belongs to the UPF0435 family
DM447_RS08545	COG1196	nuclear chromosome segregation
DM447_RS08550	COG0552	protein localization to endoplasmic reticulum
DM447_RS08555	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
DM447_RS08560	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DM447_RS08565	COG0228	four-way junction DNA binding
DM447_RS08570	COG1837	Belongs to the UPF0109 family
DM447_RS08580	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DM447_RS08590	COG0335	large ribosomal subunit rRNA binding
DM447_RS08600	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
DM447_RS08605	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DM447_RS08615	COG2257	FlhB HrpN YscU SpaS Family
DM447_RS08620	COG0758	DNA mediated transformation
DM447_RS08625	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DM447_RS08630	COG4974	Belongs to the 'phage' integrase family
DM447_RS08635	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
DM447_RS08640	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
DM447_RS08645	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
DM447_RS08650	COG1815	bacterial-type flagellum-dependent cell motility
DM447_RS08655	COG1558	bacterial-type flagellum-dependent cell motility
DM447_RS08660	COG1677	Flagellar hook-basal body complex protein FliE
DM447_RS08665	COG1766	The M ring may be actively involved in energy transduction
DM447_RS08670	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DM447_RS08675	COG1317	bacterial-type flagellum organization
DM447_RS08680	COG1157	protein secretion by the type III secretion system
DM447_RS08700	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
DM447_RS08710	COG4786	Flagellar basal body rod
DM447_RS08715	COG1582	Flagellar protein (FlbD)
DM447_RS08725	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DM447_RS08730	COG1776	CheC inhibitor of MCP methylation
DM447_RS08730	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DM447_RS08735	COG2201	protein-glutamate methylesterase activity
DM447_RS08740	COG3190	flagellar
DM447_RS08745	COG1338	Plays a role in the flagellum-specific transport system
DM447_RS08750	COG1987	bacterial-type flagellum assembly
DM447_RS08755	COG1684	flagellar biosynthetic protein fliR
DM447_RS08760	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DM447_RS08765	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DM447_RS08770	COG1419	protein localization to endoplasmic reticulum
DM447_RS08775	COG0455	bacterial-type flagellum organization
DM447_RS08780	COG2201	protein-glutamate methylesterase activity
DM447_RS08785	COG2198	Histidine kinase
DM447_RS08785	COG0643	Histidine kinase
DM447_RS08790	COG0835	chemotaxis
DM447_RS08795	COG1776	CheC inhibitor of MCP methylation
DM447_RS08800	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
DM447_RS08805	COG1191	sigma factor activity
DM447_RS08825	COG0052	Belongs to the universal ribosomal protein uS2 family
DM447_RS08830	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DM447_RS08835	COG0528	UMP kinase activity
DM447_RS08840	COG0233	cytoplasmic translational termination
DM447_RS08845	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DM447_RS08850	COG4589	Belongs to the CDS family
DM447_RS08855	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
DM447_RS08860	COG0750	zinc metalloprotease
DM447_RS08865	COG0442	prolyl-tRNA aminoacylation
DM447_RS08870	COG2176	DNA-directed DNA polymerase activity
DM447_RS08875	COG0779	Required for maturation of 30S ribosomal subunits
DM447_RS08880	COG0195	Participates in both transcription termination and antitermination
DM447_RS08885	COG2740	Nucleic-acid-binding protein implicated in transcription termination
DM447_RS08895	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DM447_RS08900	COG1550	Protein conserved in bacteria
DM447_RS08905	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DM447_RS08910	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DM447_RS08915	COG0196	riboflavin kinase activity
DM447_RS08920	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DM447_RS08925	COG1185	polyribonucleotide nucleotidyltransferase activity
DM447_RS08930	COG0612	Peptidase, M16
DM447_RS08935	COG1873	PFAM PRC-barrel domain
DM447_RS08940	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DM447_RS08945	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DM447_RS08950	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DM447_RS08955	COG0527	aspartate kinase activity
DM447_RS08965	COG0740	serine-type endopeptidase activity
DM447_RS08975	COG1674	ftsk spoiiie
DM447_RS08980	COG1744	ABC transporter substrate-binding protein PnrA-like
DM447_RS08985	COG3845	ABC transporter
DM447_RS08990	COG4603	Belongs to the binding-protein-dependent transport system permease family
DM447_RS08995	COG1079	Belongs to the binding-protein-dependent transport system permease family
DM447_RS09000	COG0612	Peptidase, M16
DM447_RS09005	COG0612	Peptidase, M16
DM447_RS09010	COG0300	oxidoreductase activity
DM447_RS09020	COG1426	Protein conserved in bacteria
DM447_RS09025	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DM447_RS09030	COG1546	Belongs to the CinA family
DM447_RS09030	COG1058	Belongs to the CinA family
DM447_RS09035	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DM447_RS09040	COG1418	mRNA catabolic process
DM447_RS09045	COG1692	metallophosphoesterase
DM447_RS09050	COG2359	stage V sporulation protein S
DM447_RS09060	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DM447_RS09065	COG4550	Control of competence regulator ComK, YlbF/YmcA
DM447_RS09075	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DM447_RS09080	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DM447_RS09085	COG0783	Belongs to the Dps family
DM447_RS09090	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DM447_RS09095	COG1923	regulation of RNA biosynthetic process
DM447_RS09105	COG0464	growth
DM447_RS09110	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DM447_RS09115	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
DM447_RS09120	COG0789	Transcriptional regulator
DM447_RS09125	COG0174	glutamine synthetase
DM447_RS09135	COG0300	oxidoreductase activity
DM447_RS09140	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DM447_RS09145	COG1388	LysM domain
DM447_RS09145	COG0791	NLP P60 protein
DM447_RS09160	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DM447_RS09170	COG2814	Major facilitator Superfamily
DM447_RS09185	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DM447_RS09190	COG2223	nitrite transmembrane transporter activity
DM447_RS09200	COG0431	NADPH-dependent FMN reductase
DM447_RS09205	COG1072	(Pantothenic acid kinase))
DM447_RS09225	COG1131	(ABC) transporter
DM447_RS09245	COG0300	oxidoreductase activity
DM447_RS09260	COG0840	transmembrane signaling receptor activity
DM447_RS09270	COG0328	RNA-DNA hybrid ribonuclease activity
DM447_RS09270	COG3341	Caulimovirus viroplasmin
DM447_RS09290	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DM447_RS09320	COG1737	Transcriptional regulator
DM447_RS09325	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
DM447_RS09330	COG2610	gluconate transmembrane transporter activity
DM447_RS09335	COG1070	Carbohydrate kinase
DM447_RS09345	COG2972	Histidine kinase
DM447_RS09350	COG2207	Transcriptional regulator
DM447_RS09350	COG4753	response regulator
DM447_RS09355	COG4213	ABC transporter substrate-binding protein
DM447_RS09365	COG4214	carbohydrate transport
DM447_RS09375	COG0463	Glycosyl transferase, family 2
DM447_RS09385	COG4485	Bacterial membrane protein, YfhO
DM447_RS09395	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DM447_RS09400	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DM447_RS09405	COG4224	UPF0291 protein
DM447_RS09420	COG3763	UPF0154 protein
DM447_RS09425	COG4846	Membrane protein involved in cytochrome C biogenesis
DM447_RS09430	COG4191	Histidine kinase
DM447_RS09440	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DM447_RS09470	COG0464	growth
DM447_RS09475	COG0824	Thioesterase
DM447_RS09485	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DM447_RS09490	COG1469	GTP cyclohydrolase I activity
DM447_RS09495	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
DM447_RS09505	COG1174	glycine betaine transport
DM447_RS09510	COG1832	CoA-binding protein
DM447_RS09515	COG0187	DNA topoisomerase II activity
DM447_RS09520	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DM447_RS09525	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DM447_RS09535	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DM447_RS09540	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
DM447_RS09545	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DM447_RS09550	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DM447_RS09555	COG0131	Imidazoleglycerol-phosphate dehydratase
DM447_RS09560	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DM447_RS09570	COG0107	imidazoleglycerol-phosphate synthase activity
DM447_RS09575	COG0140	phosphoribosyl-ATP diphosphatase activity
DM447_RS09575	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DM447_RS09580	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DM447_RS09585	COG0765	amino acid transport
DM447_RS09590	COG1126	abc transporter atp-binding protein
DM447_RS09595	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DM447_RS09635	COG2814	Major facilitator Superfamily
DM447_RS09645	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DM447_RS09650	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DM447_RS09660	COG0583	DNA-binding transcription factor activity
DM447_RS09665	COG0070	glutamate synthase
DM447_RS09665	COG0069	glutamate synthase activity
DM447_RS09665	COG0067	glutamate synthase
DM447_RS09670	COG0493	'glutamate synthase
DM447_RS09680	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DM447_RS09685	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DM447_RS09705	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DM447_RS09715	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DM447_RS09720	COG0702	epimerase
DM447_RS09730	COG2996	Protein conserved in bacteria
DM447_RS09740	COG0840	transmembrane signaling receptor activity
DM447_RS09760	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DM447_RS09765	COG1271	oxidase subunit
DM447_RS09770	COG1294	oxidase, subunit
DM447_RS09775	COG4988	ABC transporter
DM447_RS09780	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
DM447_RS09785	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DM447_RS09800	COG1063	alcohol dehydrogenase
DM447_RS09810	COG3546	catalase activity
DM447_RS09815	COG1113	amino acid transport
DM447_RS09820	COG1280	lysine exporter protein (LysE YggA)
DM447_RS09825	COG3546	catalase activity
DM447_RS09835	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DM447_RS09860	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DM447_RS09865	COG0720	synthase
DM447_RS09870	COG0602	queuosine metabolic process
DM447_RS09875	COG1968	undecaprenyl-diphosphatase activity
DM447_RS09880	COG0582	viral genome integration into host DNA
DM447_RS09890	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DM447_RS09905	COG4589	Belongs to the CDS family
DM447_RS09930	COG0726	polysaccharide deacetylase
DM447_RS09935	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
DM447_RS09940	COG3639	organic phosphonate transmembrane transporter activity
DM447_RS09945	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
DM447_RS09965	COG0662	Cupin 2, conserved barrel domain protein
DM447_RS09990	COG1902	pentaerythritol trinitrate reductase activity
DM447_RS09990	COG0446	pyridine nucleotide-disulphide oxidoreductase
DM447_RS09995	COG0183	Belongs to the thiolase family
DM447_RS10000	COG3425	synthase
DM447_RS10020	COG4894	glucomannan catabolic process
DM447_RS10035	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
DM447_RS10055	COG1247	-acetyltransferase
DM447_RS10070	COG1114	Component of the transport system for branched-chain amino acids
DM447_RS10085	COG0438	transferase activity, transferring glycosyl groups
DM447_RS10095	COG0596	Alpha beta hydrolase
DM447_RS10100	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DM447_RS10100	COG0723	plastoquinol--plastocyanin reductase activity
DM447_RS10105	COG0826	peptidase U32
DM447_RS10110	COG0826	peptidase U32
DM447_RS10115	COG3191	aminopeptidase activity
DM447_RS10140	COG3180	Ammonia monooxygenase
DM447_RS10145	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DM447_RS10145	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DM447_RS10160	COG0419	ATPase involved in DNA repair
DM447_RS10165	COG0420	3'-5' exonuclease activity
DM447_RS10170	COG4479	Belongs to the UPF0346 family
DM447_RS10175	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DM447_RS10185	COG0791	NLP P60 protein
DM447_RS10185	COG1388	LysM domain
DM447_RS10190	COG1418	mRNA catabolic process
DM447_RS10195	COG1801	Protein of unknown function DUF72
DM447_RS10200	COG0328	RNA-DNA hybrid ribonuclease activity
DM447_RS10235	COG0494	nUDIX hydrolase
DM447_RS10240	COG2267	carboxylic ester hydrolase activity
DM447_RS10265	COG1335	isochorismatase
DM447_RS10285	COG1316	TRANSCRIPTIONal
DM447_RS10315	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
DM447_RS10320	COG0116	Belongs to the methyltransferase superfamily
DM447_RS10330	COG3599	regulation of cell shape
DM447_RS10335	COG4474	Belongs to the UPF0398 family
DM447_RS10345	COG0295	cytidine deaminase activity
DM447_RS10360	COG3331	DNA recombination
DM447_RS10365	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DM447_RS10365	COG4499	WXG100 protein secretion system (Wss), protein YukC
DM447_RS10375	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DM447_RS10380	COG3935	DnaD domain protein
DM447_RS10385	COG0017	Asparaginyl-tRNA synthetase
DM447_RS10390	COG0436	Aminotransferase
DM447_RS10410	COG1199	ATP-dependent helicase activity
DM447_RS10410	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DM447_RS10415	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
DM447_RS10420	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DM447_RS10435	COG0617	tRNA 3'-terminal CCA addition
DM447_RS10440	COG0438	transferase activity, transferring glycosyl groups
DM447_RS10445	COG1803	Methylglyoxal synthase
DM447_RS10455	COG1694	Mazg nucleotide pyrophosphohydrolase
DM447_RS10460	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DM447_RS10465	COG2738	Putative neutral zinc metallopeptidase
DM447_RS10475	COG4347	Protein of unknown function (DUF1405)
DM447_RS10480	COG5582	Belongs to the UPF0302 family
DM447_RS10485	COG0457	Tetratricopeptide repeat
DM447_RS10490	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DM447_RS10495	COG0287	Prephenate dehydrogenase
DM447_RS10500	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DM447_RS10505	COG4401	Chorismate mutase type I
DM447_RS10510	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DM447_RS10515	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DM447_RS10520	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DM447_RS10525	COG0105	UTP biosynthetic process
DM447_RS10530	COG0142	geranyltranstransferase activity
DM447_RS10535	COG2226	methyltransferase
DM447_RS10540	COG0142	geranyltranstransferase activity
DM447_RS10550	COG0776	regulation of translation
DM447_RS10555	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
DM447_RS10565	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DM447_RS10570	COG1160	GTP binding
DM447_RS10590	COG0539	negative regulation of cytoplasmic translation
DM447_RS10595	COG0204	Acyl-transferase
DM447_RS10605	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
DM447_RS10610	COG2959	enzyme of heme biosynthesis
DM447_RS10615	COG3409	Peptidoglycan-binding domain 1 protein
DM447_RS10615	COG3773	Cell wall hydrolase
DM447_RS10620	COG2339	peptidase activity
DM447_RS10630	COG0492	ferredoxin-NADP+ reductase activity
DM447_RS10635	COG4862	establishment of competence for transformation
DM447_RS10640	COG0517	IMP dehydrogenase activity
DM447_RS10655	COG3546	catalase activity
DM447_RS10665	COG1266	CAAX protease self-immunity
DM447_RS10670	COG0514	ATP-dependent DNA helicase (RecQ)
DM447_RS10675	COG4955	Helix-turn-helix domain
DM447_RS10680	COG1141	Ferredoxin
DM447_RS10690	COG1595	DNA-templated transcription, initiation
DM447_RS10705	COG5002	protein histidine kinase activity
DM447_RS10710	COG0745	RESPONSE REGULATOR receiver
DM447_RS10715	COG1187	pseudouridine synthase activity
DM447_RS10720	COG0700	Nucleoside recognition
DM447_RS10725	COG2715	membrane protein required for spore maturation
DM447_RS10730	COG1686	Belongs to the peptidase S11 family
DM447_RS10735	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DM447_RS10740	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DM447_RS10745	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DM447_RS10755	COG4533	DNA binding
DM447_RS10765	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DM447_RS10775	COG0697	spore germination
DM447_RS10800	COG2172	sigma factor antagonist activity
DM447_RS10810	COG1686	Belongs to the peptidase S11 family
DM447_RS10825	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
DM447_RS10830	COG4974	Belongs to the 'phage' integrase family
DM447_RS10840	COG0735	belongs to the Fur family
DM447_RS10845	COG1300	Membrane
DM447_RS10850	COG1379	DNA repair
DM447_RS10860	COG0667	Aldo Keto reductase
DM447_RS10865	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DM447_RS10885	COG0300	oxidoreductase activity
DM447_RS10890	COG0584	glycerophosphoryl diester phosphodiesterase
DM447_RS10895	COG1902	pentaerythritol trinitrate reductase activity
DM447_RS10900	COG1234	tRNA 3'-trailer cleavage
DM447_RS10905	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DM447_RS10910	COG2195	Cleaves the N-terminal amino acid of tripeptides
DM447_RS10915	COG1376	ErfK ybiS ycfS ynhG family protein
DM447_RS10920	COG4129	membrane
DM447_RS10940	COG0840	transmembrane signaling receptor activity
DM447_RS10945	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DM447_RS10950	COG0840	transmembrane signaling receptor activity
DM447_RS10955	COG4989	oxidoreductase activity
DM447_RS10960	COG0508	dehydrogenase complex catalyzes the overall conversion of
DM447_RS10965	COG0022	dehydrogenase e1 component
DM447_RS10970	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DM447_RS10975	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DM447_RS10985	COG3829	transcription factor binding
DM447_RS10985	COG3290	protein histidine kinase activity
DM447_RS10995	COG0527	aspartate kinase activity
DM447_RS11000	COG2340	Cysteine-rich secretory protein family
DM447_RS11005	COG0745	RESPONSE REGULATOR receiver
DM447_RS11020	COG1438	arginine binding
DM447_RS11025	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
DM447_RS11045	COG1722	exodeoxyribonuclease VII activity
DM447_RS11050	COG1570	exodeoxyribonuclease VII activity
DM447_RS11055	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DM447_RS11060	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DM447_RS11065	COG1302	Protein conserved in bacteria
DM447_RS11070	COG0439	Biotin carboxylase
DM447_RS11075	COG0511	ligase activity, forming carbon-carbon bonds
DM447_RS11115	COG3854	ATPases associated with a variety of cellular activities
DM447_RS11140	COG1752	Esterase of the alpha-beta hydrolase superfamily
DM447_RS11150	COG1595	DNA-templated transcription, initiation
DM447_RS11160	COG1321	iron dependent repressor
DM447_RS11165	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DM447_RS11170	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DM447_RS11175	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DM447_RS11180	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DM447_RS11185	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DM447_RS11200	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DM447_RS11205	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DM447_RS11210	COG1459	type II secretion system
DM447_RS11215	COG4537	Required for transformation and DNA binding
DM447_RS11245	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DM447_RS11255	COG1368	sulfuric ester hydrolase activity
DM447_RS11260	COG1940	carbohydrate kinase activity
DM447_RS11265	COG4483	Protein conserved in bacteria
DM447_RS11270	COG0697	spore germination
DM447_RS11280	COG0705	Rhomboid family
DM447_RS11280	COG0457	Tetratricopeptide repeat
DM447_RS11290	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DM447_RS11310	COG0704	Plays a role in the regulation of phosphate uptake
DM447_RS11315	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DM447_RS11320	COG0581	inorganic phosphate transmembrane transporter activity
DM447_RS11325	COG0573	inorganic phosphate transmembrane transporter activity
DM447_RS11330	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DM447_RS11335	COG0768	penicillin binding
DM447_RS11340	COG0477	Major facilitator Superfamily
DM447_RS11350	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DM447_RS11405	COG4709	membrane
DM447_RS11420	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
DM447_RS11425	COG0513	Belongs to the DEAD box helicase family
DM447_RS11430	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DM447_RS11435	COG2384	SAM-dependent methyltransferase
DM447_RS11445	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DM447_RS11450	COG0358	DNA primase activity
DM447_RS11455	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
DM447_RS11460	COG0751	glycine-tRNA ligase activity
DM447_RS11465	COG0752	glycyl-tRNA synthetase alpha subunit
DM447_RS11470	COG1381	Involved in DNA repair and RecF pathway recombination
DM447_RS11480	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DM447_RS11485	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
DM447_RS11490	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DM447_RS11495	COG1480	7TM receptor with intracellular HD hydrolase
DM447_RS11500	COG1702	phosphate starvation-inducible protein PhoH
DM447_RS11520	COG4864	UPF0365 protein
DM447_RS11525	COG1030	water channel activity
DM447_RS11530	COG1610	YqeY-like protein
DM447_RS11535	COG0828	Belongs to the bacterial ribosomal protein bS21 family
DM447_RS11540	COG1283	sodium-dependent phosphate transmembrane transporter activity
DM447_RS11545	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DM447_RS11550	COG2264	protein methyltransferase activity
DM447_RS11555	COG0484	heat shock protein binding
DM447_RS11560	COG0443	Heat shock 70 kDa protein
DM447_RS11565	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DM447_RS11570	COG1420	regulation of RNA biosynthetic process
DM447_RS11575	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DM447_RS11610	COG3409	Peptidoglycan-binding domain 1 protein
DM447_RS11610	COG5632	N-Acetylmuramoyl-L-alanine amidase
DM447_RS11705	COG0740	serine-type endopeptidase activity
DM447_RS11730	COG1074	ATP-dependent DNA helicase activity
DM447_RS11735	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DM447_RS11740	COG0582	viral genome integration into host DNA
DM447_RS11765	COG0629	single-stranded DNA binding
DM447_RS11835	COG0481	GTPase activity
DM447_RS11845	COG0860	N-Acetylmuramoyl-L-alanine amidase
DM447_RS11850	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
DM447_RS11855	COG0268	Binds directly to 16S ribosomal RNA
DM447_RS11860	COG1466	dna polymerase III delta subunit
DM447_RS11865	COG2333	competence protein COMEC
DM447_RS11865	COG0658	competence protein
DM447_RS11870	COG2131	deaminase
DM447_RS11875	COG1555	photosystem II stabilization
DM447_RS11880	COG2226	methyltransferase
DM447_RS11885	COG0799	negative regulation of ribosome biogenesis
DM447_RS11890	COG1713	HD superfamily hydrolase involved in NAD metabolism
DM447_RS11895	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DM447_RS11900	COG1534	Rna-binding protein
DM447_RS11905	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DM447_RS11910	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
DM447_RS11915	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
DM447_RS11935	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DM447_RS11945	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DM447_RS11950	COG0572	uridine kinase
DM447_RS11955	COG4122	O-methyltransferase activity
DM447_RS11960	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DM447_RS11965	COG3906	Belongs to the UPF0473 family
DM447_RS11970	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DM447_RS11975	COG4472	Bacterial protein of unknown function (DUF965)
DM447_RS11980	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DM447_RS11985	COG0628	permease
DM447_RS11995	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DM447_RS12005	COG0482	sulfurtransferase activity
DM447_RS12010	COG1104	cysteine desulfurase activity
DM447_RS12015	COG1959	2 iron, 2 sulfur cluster binding
DM447_RS12020	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DM447_RS12035	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DM447_RS12040	COG0124	histidyl-tRNA synthetase
DM447_RS12045	COG0860	N-Acetylmuramoyl-L-alanine amidase
DM447_RS12045	COG4991	sh3 domain protein
DM447_RS12045	COG3103	Sh3 type 3 domain protein
DM447_RS12060	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DM447_RS12065	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DM447_RS12070	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
DM447_RS12070	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DM447_RS12075	COG5416	Lipopolysaccharide assembly protein A domain
DM447_RS12080	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DM447_RS12080	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DM447_RS12090	COG2244	polysaccharide biosynthetic process
DM447_RS12095	COG2323	membrane
DM447_RS12100	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DM447_RS12110	COG1862	Preprotein translocase
DM447_RS12120	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DM447_RS12130	COG2255	four-way junction helicase activity
DM447_RS12135	COG0632	four-way junction helicase activity
DM447_RS12150	COG0217	transcriptional regulatory protein
DM447_RS12155	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DM447_RS12165	COG1388	LysM domain
DM447_RS12175	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DM447_RS12180	COG0157	Belongs to the NadC ModD family
DM447_RS12185	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DM447_RS12190	COG1104	cysteine desulfurase activity
DM447_RS12195	COG1827	regulation of RNA biosynthetic process
DM447_RS12205	COG0077	Prephenate dehydratase
DM447_RS12210	COG4492	Belongs to the UPF0735 family
DM447_RS12215	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DM447_RS12220	COG3290	protein histidine kinase activity
DM447_RS12225	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DM447_RS12230	COG2868	ribosomal protein
DM447_RS12235	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DM447_RS12240	COG1530	ribonuclease E activity
DM447_RS12245	COG1994	Peptidase M50
DM447_RS12255	COG2894	cell division
DM447_RS12260	COG0850	regulation of cytokinetic process
DM447_RS12275	COG1077	Cell shape determining protein MreB Mrl
DM447_RS12280	COG2003	Belongs to the UPF0758 family
DM447_RS12305	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
DM447_RS12310	COG2165	general secretion pathway protein
DM447_RS12315	COG1459	type II secretion system
DM447_RS12325	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DM447_RS12345	COG3706	GGDEF domain
DM447_RS12350	COG0285	dihydrofolate synthase activity
DM447_RS12355	COG0189	ligase activity
DM447_RS12360	COG0525	valine-tRNA ligase activity
DM447_RS12375	COG1388	LysM domain
DM447_RS12375	COG1388	LysM domain
DM447_RS12380	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DM447_RS12385	COG0113	porphobilinogen synthase activity
DM447_RS12395	COG0181	hydroxymethylbilane synthase activity
DM447_RS12400	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DM447_RS12410	COG0218	Necessary for normal cell division and for the maintenance of normal septation
DM447_RS12420	COG0470	DNA polymerase III
DM447_RS12420	COG1067	ATP-dependent peptidase activity
DM447_RS12425	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DM447_RS12430	COG0544	peptidyl-prolyl cis-trans isomerase activity
DM447_RS12460	COG2146	nitrite reductase [NAD(P)H] activity
DM447_RS12465	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DM447_RS12515	COG0622	Phosphoesterase
DM447_RS12520	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DM447_RS12525	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DM447_RS12530	COG5401	PFAM Sporulation and spore germination
DM447_RS12535	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DM447_RS12540	COG1846	Transcriptional regulator
DM447_RS12545	COG0515	serine threonine protein kinase
DM447_RS12545	COG2815	serine threonine protein kinase
DM447_RS12550	COG1136	(ABC) transporter
DM447_RS12555	COG0577	efflux transmembrane transporter activity
DM447_RS12560	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DM447_RS12570	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DM447_RS12575	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DM447_RS12580	COG0243	molybdopterin cofactor binding
DM447_RS12590	COG2197	response regulator
DM447_RS12610	COG2197	response regulator
DM447_RS12620	COG1719	4-vinyl reductase, 4VR
DM447_RS12630	COG0322	excinuclease ABC activity
DM447_RS12635	COG3118	belongs to the thioredoxin family
DM447_RS12640	COG3766	membrane
DM447_RS12645	COG1193	negative regulation of DNA recombination
DM447_RS12650	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DM447_RS12650	COG1796	DNA polymerase
DM447_RS12655	COG1286	toxin biosynthetic process
DM447_RS12660	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
DM447_RS12665	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DM447_RS12690	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DM447_RS12690	COG0072	phenylalanine-tRNA ligase activity
DM447_RS12695	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DM447_RS12700	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DM447_RS12710	COG0741	lytic transglycosylase activity
DM447_RS12715	COG1363	Peptidase, m42
DM447_RS12730	COG0398	Pfam SNARE associated Golgi protein
DM447_RS12740	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DM447_RS12745	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DM447_RS12750	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DM447_RS12755	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DM447_RS12765	COG1484	DNA-dependent DNA replication
DM447_RS12770	COG3611	Membrane attachment protein
DM447_RS12775	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DM447_RS12785	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
DM447_RS12790	COG0237	dephospho-CoA kinase activity
DM447_RS12795	COG1971	Probably functions as a manganese efflux pump
DM447_RS12800	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DM447_RS12805	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DM447_RS12805	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DM447_RS12810	COG5002	protein histidine kinase activity
DM447_RS12815	COG0745	RESPONSE REGULATOR receiver
DM447_RS12825	COG0538	isocitrate dehydrogenase activity
DM447_RS12830	COG0372	Belongs to the citrate synthase family
DM447_RS12835	COG2707	UPF0756 membrane protein
DM447_RS12840	COG0628	permease
DM447_RS12845	COG3030	protein affecting phage T7 exclusion by the F plasmid
DM447_RS12855	COG0205	6-phosphofructokinase activity
DM447_RS12860	COG0825	malonyl-CoA metabolic process
DM447_RS12865	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
DM447_RS12870	COG0587	DNA-directed DNA polymerase activity
DM447_RS12885	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DM447_RS12890	COG4109	DRTGG domain
DM447_RS12905	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DM447_RS12910	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DM447_RS12915	COG3766	membrane
DM447_RS12925	COG1842	Phage shock protein A
DM447_RS12935	COG1028	Short-chain dehydrogenase reductase Sdr
DM447_RS12940	COG0589	response to stress
DM447_RS12945	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DM447_RS12950	COG0827	DNA restriction-modification system
DM447_RS12955	COG3874	Sporulation protein YtfJ
DM447_RS12965	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DM447_RS12970	COG1574	metal-dependent hydrolase with the TIM-barrel fold
DM447_RS12980	COG0301	tRNA thio-modification
DM447_RS12985	COG1104	cysteine desulfurase activity
DM447_RS12995	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
DM447_RS13000	COG1956	GAF domain-containing protein
DM447_RS13005	COG2203	Gaf domain
DM447_RS13005	COG2199	diguanylate cyclase activity
DM447_RS13010	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DM447_RS13120	COG1793	dna ligase
DM447_RS13120	COG3285	dna ligase
DM447_RS13125	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
DM447_RS13130	COG2391	methyltransferase activity
DM447_RS13140	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DM447_RS13145	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DM447_RS13170	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
DM447_RS13170	COG1605	Chorismate mutase
DM447_RS13175	COG0849	cell division
DM447_RS13180	COG4980	gas vesicle protein
DM447_RS13190	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DM447_RS13200	COG1674	ftsk spoiiie
DM447_RS13205	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DM447_RS13210	COG4848	Belongs to the UPF0354 family
DM447_RS13215	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DM447_RS13225	COG0840	transmembrane signaling receptor activity
DM447_RS13235	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
DM447_RS13240	COG1363	Peptidase, m42
DM447_RS13245	COG5584	Small secreted protein
DM447_RS13250	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DM447_RS13260	COG0510	thiamine kinase activity
DM447_RS13270	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
DM447_RS13280	COG1349	DNA-binding transcription factor activity
DM447_RS13285	COG1187	pseudouridine synthase activity
DM447_RS13290	COG2244	polysaccharide biosynthetic process
DM447_RS13295	COG2081	HI0933 family
DM447_RS13315	COG0495	leucyl-tRNA aminoacylation
DM447_RS13335	COG1242	4 iron, 4 sulfur cluster binding
DM447_RS13340	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
DM447_RS13350	COG4990	cell redox homeostasis
DM447_RS13355	COG0367	asparagine synthase
DM447_RS13365	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DM447_RS13375	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DM447_RS13380	COG1116	anion transmembrane transporter activity
DM447_RS13385	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DM447_RS13390	COG0494	nUDIX hydrolase
DM447_RS13405	COG1120	ATPase activity
DM447_RS13415	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DM447_RS13420	COG0318	PFAM AMP-dependent synthetase and ligase
DM447_RS13425	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
DM447_RS13430	COG2267	carboxylic ester hydrolase activity
DM447_RS13435	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
DM447_RS13440	COG1169	isochorismate synthase
DM447_RS13445	COG1575	Belongs to the MenA family. Type 1 subfamily
DM447_RS13450	COG2050	protein possibly involved in aromatic compounds catabolism
DM447_RS13455	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
DM447_RS13465	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DM447_RS13470	COG0166	Belongs to the GPI family
DM447_RS13475	COG2155	Conserved Protein
DM447_RS13480	COG1098	S1 RNA binding domain
DM447_RS13485	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DM447_RS13490	COG2032	superoxide dismutase activity
DM447_RS13495	COG0475	glutathione-regulated potassium exporter activity
DM447_RS13500	COG0490	domain, Protein
DM447_RS13505	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DM447_RS13510	COG0813	purine-nucleoside phosphorylase activity
DM447_RS13515	COG1268	BioY protein
DM447_RS13520	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
DM447_RS13525	COG3584	3D domain protein
DM447_RS13530	COG1252	NADH dehydrogenase
DM447_RS13535	COG0492	ferredoxin-NADP+ reductase activity
DM447_RS13545	COG0316	Belongs to the HesB IscA family
DM447_RS13550	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DM447_RS13555	COG4837	Protein of unknown function (DUF1462)
DM447_RS13560	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
DM447_RS13570	COG0840	transmembrane signaling receptor activity
DM447_RS13575	COG0083	homoserine kinase activity
DM447_RS13580	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DM447_RS13585	COG0460	homoserine dehydrogenase
DM447_RS13590	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DM447_RS13595	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
DM447_RS13600	COG2226	methyltransferase
DM447_RS13605	COG0746	molybdenum cofactor guanylyltransferase activity
DM447_RS13610	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DM447_RS13620	COG0303	'Molybdopterin
DM447_RS13630	COG0314	molybdopterin synthase activity
DM447_RS13635	COG0303	'Molybdopterin
DM447_RS13640	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DM447_RS13645	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DM447_RS13650	COG4470	Protein conserved in bacteria
DM447_RS13655	COG0739	heme binding
DM447_RS13670	COG0733	neurotransmitter:sodium symporter activity
DM447_RS13675	COG1757	Na H antiporter
DM447_RS13690	COG0737	Belongs to the 5'-nucleotidase family
DM447_RS13700	COG0719	Fe-S assembly protein
DM447_RS13705	COG0822	iron-sulfur transferase activity
DM447_RS13710	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DM447_RS13715	COG0719	Fe-S assembly protein
DM447_RS13720	COG0396	ATPase activity
DM447_RS13730	COG1464	Belongs to the NlpA lipoprotein family
DM447_RS13735	COG2011	ABC-type metal ion transport system permease component
DM447_RS13740	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DM447_RS13750	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DM447_RS13755	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
DM447_RS13760	COG0509	glycine decarboxylation via glycine cleavage system
DM447_RS13765	COG1393	Belongs to the ArsC family
DM447_RS13775	COG5577	PFAM Coat F domain
DM447_RS13780	COG1121	(ABC) transporter
DM447_RS13785	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DM447_RS13790	COG0735	belongs to the Fur family
DM447_RS13805	COG0589	response to stress
DM447_RS13810	COG0038	chloride channel
DM447_RS13815	COG0438	transferase activity, transferring glycosyl groups
DM447_RS13825	COG1960	acyl-CoA dehydrogenase activity
DM447_RS13830	COG0840	transmembrane signaling receptor activity
DM447_RS13835	COG2201	protein-glutamate methylesterase activity
DM447_RS13840	COG0835	chemotaxis
DM447_RS13850	COG4607	ABC-type enterochelin transport system periplasmic component
DM447_RS13855	COG4604	ABC transporter, ATP-binding protein
DM447_RS13860	COG4605	iron ion homeostasis
DM447_RS13865	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DM447_RS13880	COG3883	PFAM NLP P60 protein
DM447_RS13880	COG0791	NLP P60 protein
DM447_RS13885	COG0710	3-dehydroquinate dehydratase activity
DM447_RS13890	COG0697	spore germination
DM447_RS13900	COG0659	secondary active sulfate transmembrane transporter activity
DM447_RS13905	COG3311	Transcriptional regulator
DM447_RS13930	COG1959	2 iron, 2 sulfur cluster binding
DM447_RS13940	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DM447_RS13950	COG4509	Sortase family
DM447_RS13970	COG5386	Cell surface protein
DM447_RS13995	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DM447_RS14005	COG0557	exoribonuclease II activity
DM447_RS14010	COG1647	Serine aminopeptidase, S33
DM447_RS14015	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DM447_RS14020	COG2267	carboxylic ester hydrolase activity
DM447_RS14025	COG1349	DNA-binding transcription factor activity
DM447_RS14030	COG1105	Belongs to the carbohydrate kinase PfkB family
DM447_RS14035	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DM447_RS14040	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DM447_RS14045	COG0148	phosphopyruvate hydratase activity
DM447_RS14050	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
DM447_RS14055	COG0149	triose-phosphate isomerase activity
DM447_RS14075	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
DM447_RS14095	COG4807	Protein conserved in bacteria
DM447_RS14100	COG1250	3-hydroxyacyl-CoA dehydrogenase
DM447_RS14120	COG0740	serine-type endopeptidase activity
DM447_RS14125	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DM447_RS14130	COG1481	regulation of sporulation
DM447_RS14135	COG0391	Required for morphogenesis under gluconeogenic growth conditions
DM447_RS14140	COG1660	Displays ATPase and GTPase activities
DM447_RS14145	COG1051	belongs to the nudix hydrolase family
DM447_RS14150	COG0492	ferredoxin-NADP+ reductase activity
DM447_RS14155	COG0457	Tetratricopeptide repeat
DM447_RS14160	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DM447_RS14165	COG0110	maltose O-acetyltransferase activity
DM447_RS14170	COG0546	phosphoglycolate phosphatase activity
DM447_RS14175	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
DM447_RS14180	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DM447_RS14185	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
DM447_RS14190	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DM447_RS14195	COG1950	PFAM Membrane protein of
DM447_RS14200	COG1983	PspC domain protein
DM447_RS14210	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DM447_RS14215	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DM447_RS14220	COG0556	nucleotide-excision repair
DM447_RS14225	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
DM447_RS14230	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DM447_RS14235	COG1597	lipid kinase activity
DM447_RS14240	COG2357	RelA SpoT domain protein
DM447_RS14245	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DM447_RS14250	COG3409	Peptidoglycan-binding domain 1 protein
DM447_RS14250	COG0793	Belongs to the peptidase S41A family
DM447_RS14255	COG3883	PFAM NLP P60 protein
DM447_RS14255	COG0791	NLP P60 protein
DM447_RS14260	COG2177	Part of the ABC transporter FtsEX involved in
DM447_RS14265	COG2884	Cell division ATP-binding protein ftsE
DM447_RS14270	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DM447_RS14280	COG0653	protein targeting
DM447_RS14290	COG1501	Belongs to the glycosyl hydrolase 31 family
DM447_RS14300	COG1940	carbohydrate kinase activity
DM447_RS14310	COG0395	ABC-type sugar transport system, permease component
DM447_RS14315	COG4209	transmembrane transport
DM447_RS14335	COG0456	acetyltransferase
DM447_RS14335	COG0454	-acetyltransferase
DM447_RS14365	COG4753	response regulator
DM447_RS14365	COG2207	Transcriptional regulator
DM447_RS14370	COG2972	Histidine kinase
DM447_RS14375	COG2723	6-phospho-beta-galactosidase activity
DM447_RS14390	COG1472	Belongs to the glycosyl hydrolase 3 family
DM447_RS14395	COG1070	Carbohydrate kinase
DM447_RS14400	COG2115	Belongs to the xylose isomerase family
DM447_RS14430	COG1122	ATPase activity
DM447_RS14440	COG1737	Transcriptional regulator
DM447_RS14445	COG0840	transmembrane signaling receptor activity
DM447_RS14445	COG5278	phosphoserine phosphatase activity
DM447_RS14470	COG1733	regulation of RNA biosynthetic process
DM447_RS14475	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
DM447_RS14495	COG1516	flagellar protein fliS
DM447_RS14500	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
DM447_RS14505	COG1334	flagellar protein FlaG
DM447_RS14510	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DM447_RS14515	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
DM447_RS14520	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
DM447_RS14530	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DM447_RS14535	COG1256	bacterial-type flagellum assembly
DM447_RS14535	COG4786	Flagellar basal body rod
DM447_RS14555	COG1040	competence protein
DM447_RS14560	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
DM447_RS14565	COG1307	EDD domain protein, DegV family
DM447_RS14570	COG2197	response regulator
DM447_RS14575	COG4585	Histidine kinase
DM447_RS14580	COG1739	Uncharacterized protein family UPF0029
DM447_RS14590	COG3764	Sortase (surface protein transpeptidase)
DM447_RS14595	COG0768	penicillin binding
DM447_RS14605	COG4129	membrane
DM447_RS14610	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DM447_RS14615	COG2059	Chromate
DM447_RS14620	COG2059	Chromate
DM447_RS14625	COG1522	sequence-specific DNA binding
DM447_RS14635	COG0590	tRNA wobble adenosine to inosine editing
DM447_RS14640	COG0346	lactoylglutathione lyase activity
DM447_RS14645	COG0667	Aldo Keto reductase
DM447_RS14650	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
DM447_RS14660	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DM447_RS14660	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DM447_RS14660	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DM447_RS14670	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DM447_RS14675	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DM447_RS14680	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DM447_RS14685	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DM447_RS14690	COG1346	cytolysis
DM447_RS14700	COG0583	DNA-binding transcription factor activity
DM447_RS14710	COG2002	toxin-antitoxin pair type II binding
DM447_RS14715	COG0446	pyridine nucleotide-disulphide oxidoreductase
DM447_RS14720	COG0431	NADPH-dependent FMN reductase
DM447_RS14725	COG0673	inositol 2-dehydrogenase activity
DM447_RS14730	COG1199	ATP-dependent helicase activity
DM447_RS14760	COG1253	flavin adenine dinucleotide binding
DM447_RS14765	COG0626	cystathionine gamma-synthase activity
DM447_RS14770	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
DM447_RS14775	COG1984	allophanate hydrolase subunit 2
DM447_RS14780	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
DM447_RS14790	COG1940	carbohydrate kinase activity
DM447_RS14805	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DM447_RS14810	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DM447_RS14815	COG0640	Transcriptional regulator
DM447_RS14820	COG1272	protein, Hemolysin III
DM447_RS14825	COG0513	Belongs to the DEAD box helicase family
DM447_RS14830	COG0154	amidase activity
DM447_RS14840	COG0667	Aldo Keto reductase
DM447_RS14850	COG1028	Short-chain dehydrogenase reductase Sdr
DM447_RS14855	COG5577	PFAM Coat F domain
DM447_RS14890	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DM447_RS14895	COG1587	Uroporphyrinogen-III synthase
DM447_RS14900	COG0471	metal ion transport
DM447_RS14900	COG3273	potassium ion transport
DM447_RS14905	COG0529	Catalyzes the synthesis of activated sulfate
DM447_RS14910	COG2046	Belongs to the sulfate adenylyltransferase family
DM447_RS14915	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DM447_RS14920	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DM447_RS14925	COG0175	sulfate reduction
DM447_RS14930	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
DM447_RS14950	COG0501	Belongs to the peptidase M48B family
DM447_RS14955	COG0493	'glutamate synthase
DM447_RS14960	COG0070	glutamate synthase
DM447_RS14960	COG0069	glutamate synthase activity
DM447_RS14960	COG0067	glutamate synthase
DM447_RS14965	COG3949	Membrane
DM447_RS14970	COG0861	Integral membrane protein TerC family
DM447_RS14975	COG3859	Proton-coupled thiamine transporter YuaJ
DM447_RS14990	COG2072	flavoprotein involved in K transport
DM447_RS15000	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DM447_RS15000	COG3153	acetyltransferase
DM447_RS15005	COG3706	GGDEF domain
DM447_RS15010	COG0577	efflux transmembrane transporter activity
DM447_RS15010	COG1136	(ABC) transporter
DM447_RS15035	COG2885	chlorophyll binding
DM447_RS15035	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
DM447_RS15040	COG0646	methionine synthase
DM447_RS15040	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DM447_RS15045	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DM447_RS15075	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DM447_RS15080	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DM447_RS15100	COG3279	Response regulator of the LytR AlgR family
DM447_RS15110	COG3223	Belongs to the PsiE family
DM447_RS15120	COG1191	sigma factor activity
DM447_RS15135	COG1794	racemase activity, acting on amino acids and derivatives
DM447_RS15150	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
DM447_RS15160	COG5001	Diguanylate cyclase
DM447_RS15160	COG2203	Gaf domain
DM447_RS15160	COG3706	GGDEF domain
DM447_RS15160	COG4251	negative regulation of phosphorylation
DM447_RS15165	COG1301	dicarboxylic acid transport
DM447_RS15170	COG1028	Short-chain dehydrogenase reductase Sdr
DM447_RS15180	COG0405	Gamma-glutamyltransferase
DM447_RS15210	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
DM447_RS15215	COG2188	Transcriptional regulator
DM447_RS15220	COG0363	glucosamine-6-phosphate deaminase activity
DM447_RS15225	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DM447_RS15235	COG0515	serine threonine protein kinase
DM447_RS15240	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DM447_RS15240	COG0551	DNA topoisomerase type I activity
DM447_RS15245	COG3739	integral membrane protein
DM447_RS15250	COG2814	Major facilitator Superfamily
DM447_RS15255	COG2207	Transcriptional regulator
DM447_RS15255	COG4753	response regulator
DM447_RS15260	COG2972	Histidine kinase
DM447_RS15280	COG0561	phosphatase activity
DM447_RS15300	COG3706	GGDEF domain
DM447_RS15305	COG1132	(ABC) transporter
DM447_RS15335	COG2197	response regulator
DM447_RS15340	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DM447_RS15345	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
DM447_RS15345	COG0662	Cupin 2, conserved barrel domain protein
DM447_RS15360	COG0297	glycogen (starch) synthase activity
DM447_RS15370	COG5039	Polysaccharide pyruvyl transferase
DM447_RS15375	COG1216	Glycosyl transferase, family 2
DM447_RS15375	COG1442	glycosyl transferase family 8
DM447_RS15385	COG0438	transferase activity, transferring glycosyl groups
DM447_RS15420	COG0438	transferase activity, transferring glycosyl groups
DM447_RS15430	COG0438	transferase activity, transferring glycosyl groups
DM447_RS15435	COG1216	Glycosyl transferase, family 2
DM447_RS15440	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DM447_RS15445	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DM447_RS15450	COG0489	protein tyrosine kinase activity
DM447_RS15455	COG3944	biosynthesis protein
DM447_RS15470	COG3711	transcriptional antiterminator
DM447_RS15475	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DM447_RS15475	COG2190	(PTS) system
DM447_RS15475	COG1263	PTS System
DM447_RS15480	COG2723	6-phospho-beta-galactosidase activity
DM447_RS15485	COG1132	(ABC) transporter
DM447_RS15490	COG1132	(ABC) transporter
DM447_RS15495	COG0667	Aldo Keto reductase
DM447_RS15505	COG3976	FMN-binding domain protein
DM447_RS15505	COG1053	succinate dehydrogenase
DM447_RS15505	COG0431	NADPH-dependent FMN reductase
DM447_RS15525	COG1470	cell adhesion involved in biofilm formation
DM447_RS15535	COG0196	riboflavin kinase activity
DM447_RS15550	COG3867	Arabinogalactan endo-beta-1,4-galactanase
DM447_RS15555	COG1874	Beta-galactosidase
DM447_RS15560	COG3833	ABC-type maltose transport systems, permease component
DM447_RS15565	COG1175	transmembrane transport
DM447_RS15570	COG2182	Extracellular solute-binding protein
DM447_RS15575	COG1609	Transcriptional regulator
DM447_RS15580	COG1028	Short-chain dehydrogenase reductase Sdr
DM447_RS15585	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
DM447_RS15590	COG1263	PTS System
DM447_RS15590	COG2190	(PTS) system
DM447_RS15590	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DM447_RS15595	COG3177	Filamentation induced by cAMP protein fic
DM447_RS15625	COG2356	endonuclease I
DM447_RS15665	COG0438	transferase activity, transferring glycosyl groups
DM447_RS15680	COG1086	Polysaccharide biosynthesis protein
DM447_RS15690	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DM447_RS15700	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DM447_RS15705	COG4464	protein tyrosine phosphatase activity
DM447_RS15710	COG4464	protein tyrosine phosphatase activity
DM447_RS15715	COG4464	protein tyrosine phosphatase activity
DM447_RS15720	COG0489	protein tyrosine kinase activity
DM447_RS15725	COG3944	biosynthesis protein
DM447_RS15740	COG1388	LysM domain
DM447_RS15740	COG0791	NLP P60 protein
DM447_RS15780	COG0598	Magnesium transport protein CorA
DM447_RS15795	COG2814	Major facilitator Superfamily
DM447_RS15810	COG1316	TRANSCRIPTIONal
DM447_RS15825	COG0529	Catalyzes the synthesis of activated sulfate
DM447_RS15830	COG3273	potassium ion transport
DM447_RS15830	COG0471	metal ion transport
DM447_RS15835	COG2046	Belongs to the sulfate adenylyltransferase family
DM447_RS15860	COG1091	dTDP-4-dehydrorhamnose reductase activity
DM447_RS15885	COG0463	Glycosyl transferase, family 2
DM447_RS15900	COG1215	transferase activity, transferring glycosyl groups
DM447_RS15915	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DM447_RS15930	COG1309	transcriptional regulator
DM447_RS15940	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DM447_RS15950	COG4786	Flagellar basal body rod
DM447_RS15955	COG4786	Flagellar basal body rod
DM447_RS15960	COG1077	Cell shape determining protein MreB Mrl
DM447_RS15965	COG1609	Transcriptional regulator
DM447_RS15980	COG0739	heme binding
DM447_RS15985	COG2385	sporulation resulting in formation of a cellular spore
DM447_RS15990	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DM447_RS16000	COG4836	Membrane
DM447_RS16005	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DM447_RS16010	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DM447_RS16020	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DM447_RS16025	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DM447_RS16030	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DM447_RS16035	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DM447_RS16040	COG0356	it plays a direct role in the translocation of protons across the membrane
DM447_RS16050	COG1404	Belongs to the peptidase S8 family
DM447_RS16060	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DM447_RS16065	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DM447_RS16070	COG4475	Protein of unknown function (DUF436)
DM447_RS16075	COG0698	ribose 5-phosphate isomerase
DM447_RS16080	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DM447_RS16095	COG0009	L-threonylcarbamoyladenylate synthase
DM447_RS16110	COG2890	protein-(glutamine-N5) methyltransferase activity
DM447_RS16115	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DM447_RS16120	COG1435	thymidine kinase activity
DM447_RS16125	COG0254	rRNA binding
DM447_RS16130	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DM447_RS16135	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DM447_RS16140	COG0191	fructose-bisphosphate aldolase activity
DM447_RS16160	COG0504	CTP synthase activity
DM447_RS16165	COG3343	RNA polymerase activity
DM447_RS16175	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DM447_RS16185	COG0018	arginyl-trna synthetase
DM447_RS16195	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DM447_RS16200	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DM447_RS16210	COG1942	4-Oxalocrotonate Tautomerase
DM447_RS16225	COG3465	dGTPase activity
DM447_RS16230	COG1078	dGTPase activity
DM447_RS16235	COG0095	Lipoate-protein ligase
DM447_RS16240	COG4948	Mandelate Racemase Muconate Lactonizing
DM447_RS16245	COG0280	phosphate acetyltransferase
DM447_RS16250	COG3253	May function as heme-dependent peroxidase
DM447_RS16265	COG2363	Small membrane protein
DM447_RS16275	COG3001	Fructosamine kinase
DM447_RS16290	COG3594	Acyltransferase
DM447_RS16295	COG1253	flavin adenine dinucleotide binding
DM447_RS16305	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DM447_RS16315	COG1764	response to oxidative stress
DM447_RS16320	COG0861	Integral membrane protein TerC family
DM447_RS16325	COG0628	permease
DM447_RS16330	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DM447_RS16335	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DM447_RS16350	COG0514	ATP-dependent DNA helicase (RecQ)
DM447_RS16365	COG0488	(ABC) transporter
DM447_RS16370	COG2514	catechol 2,3-dioxygenase activity
DM447_RS16375	COG1733	regulation of RNA biosynthetic process
DM447_RS16380	COG1607	acyl-coa hydrolase
DM447_RS16385	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DM447_RS16390	COG2962	Rard protein
DM447_RS16400	COG2755	lipolytic protein G-D-S-L family
DM447_RS16420	COG2197	response regulator
DM447_RS16425	COG4585	Histidine kinase
DM447_RS16450	COG3689	TIGRFAM TIGR03943 family protein
DM447_RS16455	COG0701	Predicted permease
DM447_RS16460	COG0534	Mate efflux family protein
DM447_RS16470	COG0444	Belongs to the ABC transporter superfamily
DM447_RS16475	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DM447_RS16505	COG2271	Major facilitator Superfamily
DM447_RS16510	COG2271	Major facilitator Superfamily
DM447_RS16520	COG0488	(ABC) transporter
DM447_RS16525	COG0446	pyridine nucleotide-disulphide oxidoreductase
DM447_RS16530	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DM447_RS16535	COG0159	tryptophan synthase activity
DM447_RS16550	COG0134	indole-3-glycerol-phosphate synthase activity
DM447_RS16560	COG0512	Glutamine amidotransferase of anthranilate synthase
DM447_RS16560	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DM447_RS16565	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DM447_RS16580	COG1388	LysM domain
DM447_RS16580	COG3584	3D domain protein
DM447_RS16585	COG0737	Belongs to the 5'-nucleotidase family
DM447_RS16595	COG2723	6-phospho-beta-galactosidase activity
DM447_RS16600	COG0778	Nitroreductase
DM447_RS16605	COG2723	6-phospho-beta-galactosidase activity
DM447_RS16610	COG3119	arylsulfatase activity
DM447_RS16615	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DM447_RS16625	COG1447	Phosphotransferase system cellobiose-specific component IIA
DM447_RS16630	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DM447_RS16630	COG3711	transcriptional antiterminator
DM447_RS16635	COG0737	Belongs to the 5'-nucleotidase family
DM447_RS16635	COG1525	nuclease
DM447_RS16635	COG4085	toxin activity
DM447_RS16645	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DM447_RS16650	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
DM447_RS16655	COG2017	converts alpha-aldose to the beta-anomer
DM447_RS16670	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
DM447_RS16685	COG1940	carbohydrate kinase activity
DM447_RS16690	COG0667	Aldo Keto reductase
DM447_RS16695	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
DM447_RS16705	COG0346	lactoylglutathione lyase activity
DM447_RS16715	COG0494	nUDIX hydrolase
DM447_RS16720	COG0656	L-ascorbic acid biosynthetic process
DM447_RS16725	COG3973	AAA domain
DM447_RS16730	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
DM447_RS16735	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
DM447_RS16740	COG3639	organic phosphonate transmembrane transporter activity
DM447_RS16745	COG3639	organic phosphonate transmembrane transporter activity
DM447_RS16750	COG2814	Major facilitator Superfamily
DM447_RS16760	COG4086	secreted protein
DM447_RS16770	COG0432	Pfam Uncharacterised protein family UPF0047
DM447_RS16775	COG5578	integral membrane protein
DM447_RS16780	COG0395	ABC-type sugar transport system, permease component
DM447_RS16785	COG1175	transmembrane transport
DM447_RS16790	COG1653	transport
DM447_RS16795	COG0371	Dehydrogenase
DM447_RS16800	COG3534	alpha-L-arabinofuranosidase
DM447_RS16815	COG5578	integral membrane protein
DM447_RS16820	COG0395	ABC-type sugar transport system, permease component
DM447_RS16825	COG4209	transmembrane transport
DM447_RS16835	COG1609	Transcriptional regulator
DM447_RS16845	COG1069	ribulokinase activity
DM447_RS16860	COG0604	alcohol dehydrogenase
DM447_RS16875	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DM447_RS16880	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DM447_RS16885	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DM447_RS16890	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DM447_RS16895	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DM447_RS16900	COG0179	Fumarylacetoacetate (FAA) hydrolase
DM447_RS16905	COG3711	transcriptional antiterminator
DM447_RS16905	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DM447_RS16910	COG2723	6-phospho-beta-galactosidase activity
DM447_RS16915	COG1447	Phosphotransferase system cellobiose-specific component IIA
DM447_RS16920	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DM447_RS16925	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DM447_RS16940	COG2966	Psort location CytoplasmicMembrane, score
DM447_RS16955	COG1131	(ABC) transporter
DM447_RS16960	COG1846	Transcriptional regulator
DM447_RS16965	COG2340	Cysteine-rich secretory protein family
DM447_RS16995	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DM447_RS17000	COG0534	Mate efflux family protein
DM447_RS17005	COG1473	amidohydrolase
DM447_RS17015	COG0006	proline dipeptidase activity
DM447_RS17020	COG2508	Transcriptional regulator
DM447_RS17025	COG0789	Transcriptional regulator
DM447_RS17035	COG4841	protein insertion into membrane
DM447_RS17045	COG3940	Belongs to the glycosyl hydrolase 43 family
DM447_RS17055	COG0436	Aminotransferase
DM447_RS17060	COG1522	sequence-specific DNA binding
DM447_RS17065	COG2226	methyltransferase
DM447_RS17080	COG2351	hydroxyisourate hydrolase activity
DM447_RS17090	COG2508	Transcriptional regulator
DM447_RS17095	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DM447_RS17100	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DM447_RS17115	COG0154	amidase activity
DM447_RS17120	COG2080	2 iron, 2 sulfur cluster binding
DM447_RS17125	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DM447_RS17130	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
DM447_RS17135	COG2068	MobA-Related Protein
DM447_RS17140	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
DM447_RS17160	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
DM447_RS17160	COG3264	Mechanosensitive ion channel
DM447_RS17165	COG2188	Transcriptional regulator
DM447_RS17170	COG0366	Alpha amylase catalytic
DM447_RS17175	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DM447_RS17175	COG1263	PTS System
DM447_RS17180	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
DM447_RS17190	COG3189	MarR family transcriptional regulator
DM447_RS17195	COG2270	Major facilitator Superfamily
DM447_RS17205	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DM447_RS17215	COG2210	Belongs to the sulfur carrier protein TusA family
DM447_RS17225	COG5297	Belongs to the glycosyl hydrolase family 6
DM447_RS17230	COG0415	Belongs to the DNA photolyase family
DM447_RS17250	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DM447_RS17255	COG2249	NAD(P)H dehydrogenase (quinone) activity
DM447_RS17275	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DM447_RS17280	COG1116	anion transmembrane transporter activity
DM447_RS17285	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DM447_RS17295	COG1476	TRANSCRIPTIONal
DM447_RS17310	COG0640	Transcriptional regulator
DM447_RS17315	COG2723	6-phospho-beta-galactosidase activity
DM447_RS17320	COG1263	PTS System
DM447_RS17320	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DM447_RS17320	COG2190	(PTS) system
DM447_RS17325	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DM447_RS17350	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DM447_RS17355	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DM447_RS17360	COG2957	Belongs to the agmatine deiminase family
DM447_RS17365	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DM447_RS17390	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
DM447_RS17400	COG1959	2 iron, 2 sulfur cluster binding
DM447_RS17405	COG1309	transcriptional regulator
DM447_RS17410	COG2814	Major facilitator Superfamily
DM447_RS17440	COG0583	DNA-binding transcription factor activity
DM447_RS17445	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DM447_RS17455	COG2040	homocysteine
DM447_RS17460	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DM447_RS17490	COG0840	transmembrane signaling receptor activity
DM447_RS17495	COG3507	Belongs to the glycosyl hydrolase 43 family
DM447_RS17505	COG0322	excinuclease ABC activity
DM447_RS17510	COG1917	Cupin 2, conserved barrel domain protein
DM447_RS17510	COG4977	sequence-specific DNA binding
DM447_RS17520	COG0778	Nitroreductase
DM447_RS17525	COG1120	ATPase activity
DM447_RS17535	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DM447_RS17540	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DM447_RS17545	COG2205	protein histidine kinase activity
DM447_RS17550	COG3279	Response regulator of the LytR AlgR family
DM447_RS17565	COG1366	Belongs to the anti-sigma-factor antagonist family
DM447_RS17570	COG1733	regulation of RNA biosynthetic process
DM447_RS17575	COG2130	NADP-dependent
DM447_RS17580	COG2824	Alkylphosphonate utilization operon protein PhnA
DM447_RS17585	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
DM447_RS17610	COG3588	fructose-bisphosphate aldolase
DM447_RS17640	COG2249	NAD(P)H dehydrogenase (quinone) activity
DM447_RS17645	COG0803	Belongs to the bacterial solute-binding protein 9 family
DM447_RS17645	COG3443	Belongs to the bacterial solute-binding protein 9 family
DM447_RS17650	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DM447_RS17655	COG0726	polysaccharide deacetylase
DM447_RS17660	COG1263	PTS System
DM447_RS17660	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DM447_RS17660	COG2190	(PTS) system
DM447_RS17675	COG0579	oxidoreductase
DM447_RS17685	COG2409	Drug exporters of the RND superfamily
DM447_RS17710	COG0572	uridine kinase
DM447_RS17715	COG1120	ATPase activity
DM447_RS17720	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DM447_RS17725	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DM447_RS17745	COG3069	C4-dicarboxylate transmembrane transporter activity
DM447_RS17760	COG1510	regulation of RNA biosynthetic process
DM447_RS17770	COG0640	Transcriptional regulator
DM447_RS17775	COG2814	Major facilitator Superfamily
DM447_RS17790	COG0673	inositol 2-dehydrogenase activity
DM447_RS17795	COG3716	PTS system mannose fructose sorbose family IID component
DM447_RS17800	COG3715	PTS system
DM447_RS17825	COG0745	RESPONSE REGULATOR receiver
DM447_RS17830	COG2205	protein histidine kinase activity
DM447_RS17835	COG1131	(ABC) transporter
DM447_RS17845	COG2814	Major facilitator Superfamily
DM447_RS17870	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DM447_RS17915	COG2003	Belongs to the UPF0758 family
DM447_RS17940	COG4112	unkown
DM447_RS17970	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
DM447_RS17975	COG1846	Transcriptional regulator
DM447_RS17980	COG1764	response to oxidative stress
DM447_RS18005	COG0569	domain protein
DM447_RS18030	COG0667	Aldo Keto reductase
DM447_RS18040	COG1482	cell wall glycoprotein biosynthetic process
DM447_RS18045	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DM447_RS18050	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DM447_RS18055	COG4853	Protein conserved in bacteria
DM447_RS18065	COG5002	protein histidine kinase activity
DM447_RS18070	COG0745	RESPONSE REGULATOR receiver
DM447_RS18080	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DM447_RS18085	COG0305	Participates in initiation and elongation during chromosome replication
DM447_RS18090	COG0359	binds to the 23S rRNA
DM447_RS18095	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
DM447_RS18100	COG4241	membrane
DM447_RS18105	COG1011	Hydrolase
DM447_RS18110	COG0534	Mate efflux family protein
DM447_RS18115	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DM447_RS18120	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DM447_RS18125	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DM447_RS18130	COG0629	single-stranded DNA binding
DM447_RS18135	COG0360	Binds together with S18 to 16S ribosomal RNA
DM447_RS18140	COG0012	GTP binding
DM447_RS18145	COG4481	Protein conserved in bacteria
DM447_RS18150	COG3949	Membrane
DM447_RS18160	COG1811	Na channel or pump
DM447_RS18165	COG1475	DNA binding
DM447_RS18170	COG1192	Involved in chromosome partitioning
DM447_RS18175	COG1475	DNA binding
DM447_RS18180	COG0357	Ribosomal RNA small subunit methyltransferase G
DM447_RS18185	COG0445	tRNA wobble uridine modification
DM447_RS18190	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DM447_RS18195	COG1847	R3H domain protein
DM447_RS18205	COG0594	ribonuclease P activity
DM447_RS18210	COG0230	Belongs to the bacterial ribosomal protein bL34 family