locus-tag	class	description
B6V90_RS00005	COG0246	Mannitol dehydrogenase
B6V90_RS00010	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B6V90_RS00015	COG2323	membrane
B6V90_RS00030	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
B6V90_RS00035	COG2076	Multidrug Resistance protein
B6V90_RS00050	COG1054	Belongs to the UPF0176 family
B6V90_RS00065	COG0318	PFAM AMP-dependent synthetase and ligase
B6V90_RS00070	COG3321	synthase
B6V90_RS00070	COG1028	Short-chain dehydrogenase reductase Sdr
B6V90_RS00070	COG0604	alcohol dehydrogenase
B6V90_RS00085	COG4232	protein-disulfide reductase activity
B6V90_RS00095	COG2943	transferase activity, transferring hexosyl groups
B6V90_RS00125	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
B6V90_RS00140	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
B6V90_RS00150	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
B6V90_RS00155	COG1127	ABC transporter
B6V90_RS00165	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
B6V90_RS00190	COG1914	H( )-stimulated, divalent metal cation uptake system
B6V90_RS00210	COG0596	Alpha beta hydrolase
B6V90_RS00215	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
B6V90_RS00220	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
B6V90_RS00225	COG0194	GDP metabolic process
B6V90_RS00235	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
B6V90_RS00240	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
B6V90_RS00250	COG0535	radical SAM domain protein
B6V90_RS00255	COG0463	Glycosyl transferase, family 2
B6V90_RS00260	COG1091	dTDP-4-dehydrorhamnose reductase activity
B6V90_RS00265	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
B6V90_RS00270	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
B6V90_RS00305	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
B6V90_RS00310	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B6V90_RS00310	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B6V90_RS00320	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B6V90_RS00320	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B6V90_RS00330	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B6V90_RS00340	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B6V90_RS00355	COG0588	phosphoglycerate mutase activity
B6V90_RS00360	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
B6V90_RS00365	COG0484	heat shock protein binding
B6V90_RS00385	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
B6V90_RS00390	COG0424	maF-like protein
B6V90_RS00400	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
B6V90_RS00410	COG0656	L-ascorbic acid biosynthetic process
B6V90_RS00415	COG1621	beta-fructofuranosidase activity
B6V90_RS00435	COG0326	Molecular chaperone. Has ATPase activity
B6V90_RS00440	COG1028	Short-chain dehydrogenase reductase Sdr
B6V90_RS00485	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B6V90_RS00495	COG0534	Mate efflux family protein
B6V90_RS00510	COG1981	membrane
B6V90_RS00515	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B6V90_RS00520	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
B6V90_RS00525	COG0424	maF-like protein
B6V90_RS00575	COG2244	polysaccharide biosynthetic process
B6V90_RS00585	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
B6V90_RS00590	COG3152	Membrane
B6V90_RS00615	COG0357	Ribosomal RNA small subunit methyltransferase G
B6V90_RS00620	COG0445	tRNA wobble uridine modification
B6V90_RS00625	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
B6V90_RS00630	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B6V90_RS00635	COG1271	oxidase subunit
B6V90_RS00640	COG1294	oxidase, subunit
B6V90_RS00645	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
B6V90_RS00660	COG0508	dehydrogenase complex catalyzes the overall conversion of
B6V90_RS00670	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
B6V90_RS00680	COG0753	catalase activity
B6V90_RS00690	COG1741	Belongs to the pirin family
B6V90_RS00695	COG0583	DNA-binding transcription factor activity
B6V90_RS00700	COG0655	NAD(P)H dehydrogenase (quinone) activity
B6V90_RS00715	COG0560	Phosphoserine phosphatase
B6V90_RS00720	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
B6V90_RS00725	COG0028	Belongs to the TPP enzyme family
B6V90_RS00730	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
B6V90_RS00735	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
B6V90_RS00740	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
B6V90_RS00745	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
B6V90_RS00750	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B6V90_RS00760	COG1940	carbohydrate kinase activity
B6V90_RS00770	COG0312	modulator of DNA gyrase
B6V90_RS00780	COG0762	integral membrane protein
B6V90_RS00795	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
B6V90_RS00795	COG3008	intermembrane lipid transfer
B6V90_RS00800	COG1127	ABC transporter
B6V90_RS00805	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
B6V90_RS00810	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
B6V90_RS00815	COG0463	Glycosyl transferase, family 2
B6V90_RS00820	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
B6V90_RS00825	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
B6V90_RS00830	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B6V90_RS00835	COG0356	it plays a direct role in the translocation of protons across the membrane
B6V90_RS00840	COG5336	function for this protein is to guide the assembly of the membrane sector of the ATPase enzyme complex
B6V90_RS00845	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B6V90_RS00905	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
B6V90_RS00915	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
B6V90_RS00920	COG0193	aminoacyl-tRNA hydrolase activity
B6V90_RS00925	COG0012	GTP binding
B6V90_RS00930	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
B6V90_RS00935	COG0799	negative regulation of ribosome biogenesis
B6V90_RS00940	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
B6V90_RS00950	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B6V90_RS00995	COG0745	RESPONSE REGULATOR receiver
B6V90_RS01005	COG2267	carboxylic ester hydrolase activity
B6V90_RS01010	COG1082	Xylose isomerase domain protein TIM barrel
B6V90_RS01015	COG1760	l-serine dehydratase
B6V90_RS01025	COG3145	DNA-N1-methyladenine dioxygenase activity
B6V90_RS01050	COG0723	plastoquinol--plastocyanin reductase activity
B6V90_RS01055	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
B6V90_RS01065	COG0667	Aldo Keto reductase
B6V90_RS01070	COG0745	RESPONSE REGULATOR receiver
B6V90_RS01075	COG5002	protein histidine kinase activity
B6V90_RS01090	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B6V90_RS01100	COG1643	Atp-dependent helicase
B6V90_RS01105	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B6V90_RS01110	COG2814	Major facilitator Superfamily
B6V90_RS01130	COG1611	Belongs to the LOG family
B6V90_RS01135	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B6V90_RS01140	COG0717	Belongs to the dCTP deaminase family
B6V90_RS01160	COG0443	Heat shock 70 kDa protein
B6V90_RS01165	COG0484	heat shock protein binding
B6V90_RS01170	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
B6V90_RS01180	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
B6V90_RS01185	COG0220	tRNA (guanine-N7-)-methyltransferase activity
B6V90_RS01215	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
B6V90_RS01220	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
B6V90_RS01235	COG0133	tryptophan synthase activity
B6V90_RS01240	COG0159	tryptophan synthase activity
B6V90_RS01255	COG1448	Aminotransferase
B6V90_RS01260	COG3961	Belongs to the TPP enzyme family
B6V90_RS01265	COG1522	sequence-specific DNA binding
B6V90_RS01270	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
B6V90_RS01275	COG0285	dihydrofolate synthase activity
B6V90_RS01280	COG0305	Participates in initiation and elongation during chromosome replication
B6V90_RS01285	COG0697	spore germination
B6V90_RS01290	COG4206	TonB-dependent receptor
B6V90_RS01295	COG0730	response to heat
B6V90_RS01305	COG0175	sulfate reduction
B6V90_RS01310	COG0175	sulfate reduction
B6V90_RS01320	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
B6V90_RS01325	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
B6V90_RS01330	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
B6V90_RS01365	COG0668	transmembrane transport
B6V90_RS01375	COG1250	3-hydroxyacyl-CoA dehydrogenase
B6V90_RS01395	COG2011	ABC-type metal ion transport system permease component
B6V90_RS01405	COG3038	cytochrome b561
B6V90_RS01410	COG3794	PFAM blue (type 1) copper domain protein
B6V90_RS01415	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
B6V90_RS01435	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
B6V90_RS01440	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
B6V90_RS01465	COG0257	Belongs to the bacterial ribosomal protein bL36 family
B6V90_RS01480	COG4974	Belongs to the 'phage' integrase family
B6V90_RS01495	COG0602	queuosine metabolic process
B6V90_RS01500	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
B6V90_RS01515	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
B6V90_RS01520	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
B6V90_RS01545	COG0740	serine-type endopeptidase activity
B6V90_RS01555	COG0436	Aminotransferase
B6V90_RS01565	COG1494	fructose-1,6-bisphosphatase
B6V90_RS01570	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
B6V90_RS01570	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
B6V90_RS01590	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B6V90_RS01595	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B6V90_RS01615	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B6V90_RS01635	COG0583	DNA-binding transcription factor activity
B6V90_RS01650	COG1959	2 iron, 2 sulfur cluster binding
B6V90_RS01655	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B6V90_RS01665	COG2175	clavaminate synthase activity
B6V90_RS01670	COG1113	amino acid transport
B6V90_RS01685	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B6V90_RS01695	COG1648	precorrin-2 dehydrogenase activity
B6V90_RS01695	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B6V90_RS01700	COG4774	siderophore transport
B6V90_RS01715	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B6V90_RS01720	COG1518	maintenance of DNA repeat elements
B6V90_RS01735	COG1857	crispr-associated protein
B6V90_RS01750	COG1203	CRISPR-associated helicase, Cas3
B6V90_RS01780	COG1136	(ABC) transporter
B6V90_RS01810	COG0355	proton-transporting ATP synthase activity, rotational mechanism
B6V90_RS01815	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
B6V90_RS01820	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
B6V90_RS01825	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
B6V90_RS01830	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B6V90_RS01850	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B6V90_RS01865	COG3008	intermembrane lipid transfer
B6V90_RS01870	COG2995	paraquat-inducible protein a
B6V90_RS01885	COG3634	alkyl hydroperoxide reductase activity
B6V90_RS01895	COG0583	DNA-binding transcription factor activity
B6V90_RS01900	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
B6V90_RS01900	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
B6V90_RS01900	COG0506	proline dehydrogenase activity
B6V90_RS01905	COG0482	sulfurtransferase activity
B6V90_RS01915	COG1104	cysteine desulfurase activity
B6V90_RS01920	COG1104	cysteine desulfurase activity
B6V90_RS01925	COG2945	thiolester hydrolase activity
B6V90_RS01930	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
B6V90_RS01935	COG1002	Type II restriction enzyme, methylase subunits
B6V90_RS01940	COG1061	Type III restriction enzyme res subunit
B6V90_RS01955	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
B6V90_RS01990	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B6V90_RS02010	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B6V90_RS02015	COG0581	inorganic phosphate transmembrane transporter activity
B6V90_RS02020	COG0573	inorganic phosphate transmembrane transporter activity
B6V90_RS02025	COG0438	transferase activity, transferring glycosyl groups
B6V90_RS02025	COG1216	Glycosyl transferase, family 2
B6V90_RS02030	COG0783	Belongs to the Dps family
B6V90_RS02065	COG2274	protein secretion by the type I secretion system
B6V90_RS02070	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
B6V90_RS02095	COG0156	8-amino-7-oxononanoate synthase activity
B6V90_RS02105	COG4106	trans-aconitate 2-methyltransferase activity
B6V90_RS02110	COG4106	trans-aconitate 2-methyltransferase activity
B6V90_RS02110	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
B6V90_RS02115	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
B6V90_RS02120	COG2943	transferase activity, transferring hexosyl groups
B6V90_RS02125	COG1764	response to oxidative stress
B6V90_RS02140	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
B6V90_RS02150	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
B6V90_RS02165	COG0523	cobalamin synthesis protein
B6V90_RS02170	COG0667	Aldo Keto reductase
B6V90_RS02215	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
B6V90_RS02220	COG3158	transport of potassium into the cell
B6V90_RS02225	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B6V90_RS02240	COG0259	pyridoxamine-phosphate oxidase activity
B6V90_RS02250	COG1185	polyribonucleotide nucleotidyltransferase activity
B6V90_RS02255	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
B6V90_RS02260	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
B6V90_RS02265	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
B6V90_RS02270	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
B6V90_RS02285	COG0779	Required for maturation of 30S ribosomal subunits
B6V90_RS02295	COG0542	response to heat
B6V90_RS02305	COG0765	amino acid transport
B6V90_RS02310	COG1126	abc transporter atp-binding protein
B6V90_RS02315	COG4133	protoheme IX ABC transporter activity
B6V90_RS02320	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B6V90_RS02325	COG0439	Biotin carboxylase
B6V90_RS02330	COG0511	ligase activity, forming carbon-carbon bonds
B6V90_RS02340	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
B6V90_RS02360	COG5265	(ABC) transporter
B6V90_RS02365	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
B6V90_RS02375	COG2333	competence protein COMEC
B6V90_RS02375	COG0658	competence protein
B6V90_RS02380	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B6V90_RS02385	COG0540	Belongs to the ATCase OTCase family
B6V90_RS02390	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B6V90_RS02395	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
B6V90_RS02400	COG0758	DNA mediated transformation
B6V90_RS02405	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B6V90_RS02410	COG3409	Peptidoglycan-binding domain 1 protein
B6V90_RS02410	COG0793	Belongs to the peptidase S41A family
B6V90_RS02420	COG2885	chlorophyll binding
B6V90_RS02420	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
B6V90_RS02435	COG0187	DNA topoisomerase II activity
B6V90_RS02440	COG0656	L-ascorbic acid biosynthetic process
B6V90_RS02445	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B6V90_RS02475	COG1783	phage Terminase large subunit
B6V90_RS02640	COG1742	UPF0060 membrane protein
B6V90_RS02645	COG2860	membrane
B6V90_RS02665	COG1247	-acetyltransferase
B6V90_RS02685	COG1511	domain protein
B6V90_RS02685	COG3264	Mechanosensitive ion channel
B6V90_RS02690	COG1929	Belongs to the glycerate kinase type-1 family
B6V90_RS02695	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
B6V90_RS02700	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
B6V90_RS02710	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
B6V90_RS02735	COG2814	Major facilitator Superfamily
B6V90_RS02740	COG1566	PFAM secretion protein HlyD family protein
B6V90_RS02745	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
B6V90_RS02770	COG0590	tRNA wobble adenosine to inosine editing
B6V90_RS02775	COG1187	pseudouridine synthase activity
B6V90_RS02780	COG0742	ribosomal rna small subunit methyltransferase
B6V90_RS02785	COG1674	ftsk spoiiie
B6V90_RS02790	COG0564	pseudouridine synthase activity
B6V90_RS02800	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B6V90_RS02805	COG0778	Nitroreductase
B6V90_RS02810	COG0131	Imidazoleglycerol-phosphate dehydratase
B6V90_RS02815	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
B6V90_RS02820	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
B6V90_RS02825	COG0107	imidazoleglycerol-phosphate synthase activity
B6V90_RS02830	COG0140	phosphoribosyl-ATP diphosphatase activity
B6V90_RS02845	COG3961	Belongs to the TPP enzyme family
B6V90_RS02850	COG0583	DNA-binding transcription factor activity
B6V90_RS02860	COG4774	siderophore transport
B6V90_RS02865	COG4774	siderophore transport
B6V90_RS02870	COG4774	siderophore transport
B6V90_RS02885	COG0495	leucyl-tRNA aminoacylation
B6V90_RS02905	COG0679	Auxin Efflux Carrier
B6V90_RS02910	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B6V90_RS02915	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B6V90_RS02935	COG0138	bifunctional purine biosynthesis protein purh
B6V90_RS02955	COG0800	Aldolase
B6V90_RS02960	COG0129	dihydroxy-acid dehydratase activity
B6V90_RS02965	COG0741	lytic transglycosylase activity
B6V90_RS02975	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
B6V90_RS02985	COG0004	ammonium transporteR
B6V90_RS02995	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B6V90_RS03020	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
B6V90_RS03025	COG0343	queuine tRNA-ribosyltransferase activity
B6V90_RS03045	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
B6V90_RS03050	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B6V90_RS03055	COG0489	protein tyrosine kinase activity
B6V90_RS03070	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
B6V90_RS03150	COG3750	Belongs to the UPF0335 family
B6V90_RS03315	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
B6V90_RS03320	COG0745	RESPONSE REGULATOR receiver
B6V90_RS03325	COG2201	protein-glutamate methylesterase activity
B6V90_RS03330	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
B6V90_RS03335	COG0835	chemotaxis
B6V90_RS03340	COG0643	Histidine kinase
B6V90_RS03340	COG2198	Histidine kinase
B6V90_RS03345	COG0643	Histidine kinase
B6V90_RS03345	COG0784	Response regulator, receiver
B6V90_RS03345	COG2198	Histidine kinase
B6V90_RS03355	COG0840	transmembrane signaling receptor activity
B6V90_RS03365	COG1558	bacterial-type flagellum-dependent cell motility
B6V90_RS03370	COG1815	bacterial-type flagellum-dependent cell motility
B6V90_RS03385	COG1677	Flagellar hook-basal body complex protein FliE
B6V90_RS03395	COG1684	flagellar biosynthetic protein fliR
B6V90_RS03405	COG1749	Flagellar hook protein flgE
B6V90_RS03435	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
B6V90_RS03445	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
B6V90_RS03450	COG1360	Flagellar Motor Protein
B6V90_RS03495	COG1706	bacterial-type flagellum-dependent cell motility
B6V90_RS03515	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
B6V90_RS03525	COG1338	Plays a role in the flagellum-specific transport system
B6V90_RS03535	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
B6V90_RS03545	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
B6V90_RS03550	COG1766	The M ring may be actively involved in energy transduction
B6V90_RS03570	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
B6V90_RS03580	COG4786	Flagellar basal body rod
B6V90_RS03585	COG4786	Flagellar basal body rod
B6V90_RS03600	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
B6V90_RS03605	COG0022	dehydrogenase e1 component
B6V90_RS03645	COG0745	RESPONSE REGULATOR receiver
B6V90_RS03650	COG2249	NAD(P)H dehydrogenase (quinone) activity
B6V90_RS03655	COG2207	Transcriptional regulator
B6V90_RS03660	COG1064	alcohol dehydrogenase
B6V90_RS03680	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B6V90_RS03685	COG1902	pentaerythritol trinitrate reductase activity
B6V90_RS03690	COG0640	Transcriptional regulator
B6V90_RS03700	COG0564	pseudouridine synthase activity
B6V90_RS03710	COG0126	phosphoglycerate kinase activity
B6V90_RS03735	COG1393	Belongs to the ArsC family
B6V90_RS03750	COG1253	flavin adenine dinucleotide binding
B6V90_RS03755	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
B6V90_RS03775	COG3394	polysaccharide catabolic process
B6V90_RS03780	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B6V90_RS03795	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
B6V90_RS03805	COG1074	ATP-dependent DNA helicase activity
B6V90_RS03815	COG0802	atpase or kinase
B6V90_RS03820	COG0492	ferredoxin-NADP+ reductase activity
B6V90_RS03830	COG1217	gtp-binding protein TYPA
B6V90_RS03835	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
B6V90_RS03850	COG3104	oligopeptide transport
B6V90_RS03855	COG0484	heat shock protein binding
B6V90_RS03875	COG1566	PFAM secretion protein HlyD family protein
B6V90_RS03895	COG2983	Belongs to the UPF0260 family
B6V90_RS03915	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B6V90_RS03920	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
B6V90_RS03925	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
B6V90_RS03940	COG0659	secondary active sulfate transmembrane transporter activity
B6V90_RS03945	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
B6V90_RS03950	COG1923	regulation of RNA biosynthetic process
B6V90_RS03955	COG2204	response regulator
B6V90_RS03980	COG0167	dihydroorotate dehydrogenase activity
B6V90_RS03990	COG2814	Major facilitator Superfamily
B6V90_RS03995	COG2814	Major facilitator Superfamily
B6V90_RS04000	COG0735	belongs to the Fur family
B6V90_RS04005	COG1660	Displays ATPase and GTPase activities
B6V90_RS04010	COG2205	protein histidine kinase activity
B6V90_RS04015	COG0745	RESPONSE REGULATOR receiver
B6V90_RS04020	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
B6V90_RS04025	COG0859	PFAM glycosyl transferase family 9
B6V90_RS04030	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
B6V90_RS04035	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
B6V90_RS04045	COG0640	Transcriptional regulator
B6V90_RS04050	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
B6V90_RS04065	COG0612	Peptidase, M16
B6V90_RS04085	COG0539	negative regulation of cytoplasmic translation
B6V90_RS04090	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
B6V90_RS04095	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
B6V90_RS04115	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
B6V90_RS04120	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
B6V90_RS04140	COG0024	Methionine aminopeptidase
B6V90_RS04145	COG1686	Belongs to the peptidase S11 family
B6V90_RS04150	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
B6V90_RS04165	COG5212	phosphodiesterase
B6V90_RS04180	COG4774	siderophore transport
B6V90_RS04185	COG3128	pkhd-type hydroxylase
B6V90_RS04190	COG4771	TonB-dependent receptor
B6V90_RS04195	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
B6V90_RS04205	COG0850	regulation of cytokinetic process
B6V90_RS04215	COG2081	HI0933 family
B6V90_RS04220	COG0745	RESPONSE REGULATOR receiver
B6V90_RS04225	COG2205	protein histidine kinase activity
B6V90_RS04245	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
B6V90_RS04250	COG0081	regulation of translation
B6V90_RS04255	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
B6V90_RS04260	COG0222	ribosome binding
B6V90_RS04265	COG0085	RNA polymerase activity
B6V90_RS04270	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
B6V90_RS04275	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
B6V90_RS04280	COG0049	tRNA binding
B6V90_RS04285	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B6V90_RS04290	COG0051	transcription antitermination factor activity, RNA binding
B6V90_RS04295	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
B6V90_RS04300	COG0088	Forms part of the polypeptide exit tunnel
B6V90_RS04305	COG0089	rRNA binding
B6V90_RS04310	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
B6V90_RS04315	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
B6V90_RS04320	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
B6V90_RS04325	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
B6V90_RS04330	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
B6V90_RS04335	COG0255	Belongs to the universal ribosomal protein uL29 family
B6V90_RS04340	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
B6V90_RS04345	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
B6V90_RS04350	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
B6V90_RS04355	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
B6V90_RS04360	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
B6V90_RS04365	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
B6V90_RS04370	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
B6V90_RS04375	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
B6V90_RS04380	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
B6V90_RS04385	COG1841	ribosomal large subunit assembly
B6V90_RS04390	COG0200	Binds to the 23S rRNA
B6V90_RS04395	COG0201	protein transport
B6V90_RS04400	COG0563	adenylate kinase activity
B6V90_RS04405	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
B6V90_RS04410	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
B6V90_RS04415	COG0202	RNA polymerase activity
B6V90_RS04420	COG0203	ribosomal protein L17
B6V90_RS04430	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B6V90_RS04455	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
B6V90_RS04460	COG2189	Belongs to the N(4) N(6)-methyltransferase family
B6V90_RS04490	COG0714	Associated with various cellular activities
B6V90_RS04500	COG0617	tRNA 3'-terminal CCA addition
B6V90_RS04505	COG1132	(ABC) transporter
B6V90_RS04510	COG0494	nUDIX hydrolase
B6V90_RS04515	COG0793	Belongs to the peptidase S41A family
B6V90_RS04525	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B6V90_RS04530	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
B6V90_RS04535	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B6V90_RS04540	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B6V90_RS04545	COG0505	Belongs to the CarA family
B6V90_RS04560	COG0697	spore germination
B6V90_RS04565	COG0358	DNA primase activity
B6V90_RS04570	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B6V90_RS04575	COG0360	Binds together with S18 to 16S ribosomal RNA
B6V90_RS04580	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
B6V90_RS04585	COG0359	binds to the 23S rRNA
B6V90_RS04590	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
B6V90_RS04600	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
B6V90_RS04620	COG0795	lipopolysaccharide-transporting ATPase activity
B6V90_RS04625	COG0009	L-threonylcarbamoyladenylate synthase
B6V90_RS04630	COG1218	3'(2'),5'-bisphosphate nucleotidase
B6V90_RS04640	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
B6V90_RS04680	COG3261	NADH dehydrogenase
B6V90_RS04680	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
B6V90_RS04685	COG4771	TonB-dependent receptor
B6V90_RS04690	COG1597	lipid kinase activity
B6V90_RS04695	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B6V90_RS04705	COG0688	phosphatidylethanolamine metabolic process
B6V90_RS04710	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B6V90_RS04720	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
B6V90_RS04745	COG0542	response to heat
B6V90_RS04750	COG1678	Uncharacterized ACR, COG1678
B6V90_RS04755	COG4221	oxidoreductase activity
B6V90_RS04765	COG2226	methyltransferase
B6V90_RS04770	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
B6V90_RS04775	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B6V90_RS04780	COG0552	protein localization to endoplasmic reticulum
B6V90_RS04785	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
B6V90_RS04790	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
B6V90_RS04805	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
B6V90_RS04815	COG0488	(ABC) transporter
B6V90_RS04825	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
B6V90_RS04850	COG2835	tetraacyldisaccharide 4'-kinase activity
B6V90_RS04865	COG1396	sequence-specific DNA binding
B6V90_RS04870	COG0815	Transfers the fatty acyl group on membrane lipoproteins
B6V90_RS04885	COG4957	zinc ion binding
B6V90_RS04900	COG0778	Nitroreductase
B6V90_RS04910	COG0191	fructose-bisphosphate aldolase activity
B6V90_RS04920	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
B6V90_RS04935	COG3180	Ammonia monooxygenase
B6V90_RS04960	COG0277	FAD linked oxidase domain protein
B6V90_RS04975	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
B6V90_RS04980	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
B6V90_RS04985	COG0196	riboflavin kinase activity
B6V90_RS04990	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B6V90_RS05000	COG2137	regulation of response to DNA damage stimulus
B6V90_RS05005	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B6V90_RS05010	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B6V90_RS05015	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
B6V90_RS05020	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
B6V90_RS05070	COG3038	cytochrome b561
B6V90_RS05075	COG1012	belongs to the aldehyde dehydrogenase family
B6V90_RS05080	COG1979	alcohol dehydrogenase
B6V90_RS05085	COG1309	transcriptional regulator
B6V90_RS05115	COG0156	8-amino-7-oxononanoate synthase activity
B6V90_RS05145	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
B6V90_RS05150	COG0114	fumarate hydratase activity
B6V90_RS05155	COG0281	malic enzyme
B6V90_RS05170	COG3088	subunit of a heme lyase
B6V90_RS05175	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B6V90_RS05180	COG1138	Cytochrome C-type biogenesis protein
B6V90_RS05185	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
B6V90_RS05215	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
B6V90_RS05225	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
B6V90_RS05235	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
B6V90_RS05240	COG0564	pseudouridine synthase activity
B6V90_RS05255	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
B6V90_RS05255	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
B6V90_RS05260	COG2967	ApaG domain
B6V90_RS05275	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
B6V90_RS05280	COG4771	TonB-dependent receptor
B6V90_RS05285	COG1410	methionine synthase
B6V90_RS05285	COG0646	methionine synthase
B6V90_RS05300	COG1252	NADH dehydrogenase
B6V90_RS05305	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
B6V90_RS05310	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B6V90_RS05315	COG0653	protein targeting
B6V90_RS05320	COG0217	transcriptional regulatory protein
B6V90_RS05325	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
B6V90_RS05330	COG0632	four-way junction helicase activity
B6V90_RS05335	COG2255	four-way junction helicase activity
B6V90_RS05340	COG0824	Thioesterase
B6V90_RS05345	COG0811	peptide transport
B6V90_RS05350	COG0848	biopolymer transport protein
B6V90_RS05360	COG0823	Involved in the tonB-independent uptake of proteins
B6V90_RS05365	COG2885	chlorophyll binding
B6V90_RS05375	COG0037	tRNA processing
B6V90_RS05380	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B6V90_RS05385	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B6V90_RS05400	COG2309	aminopeptidase activity
B6V90_RS05405	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B6V90_RS05420	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
B6V90_RS05425	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
B6V90_RS05430	COG0561	phosphatase activity
B6V90_RS05435	COG0363	glucosamine-6-phosphate deaminase activity
B6V90_RS05440	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
B6V90_RS05445	COG3265	gluconokinase activity
B6V90_RS05460	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
B6V90_RS05465	COG0371	Dehydrogenase
B6V90_RS05480	COG2985	domain, Protein
B6V90_RS05485	COG2985	domain, Protein
B6V90_RS05490	COG0252	asparaginase activity
B6V90_RS05510	COG0473	3-isopropylmalate dehydrogenase activity
B6V90_RS05520	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
B6V90_RS05530	COG2814	Major facilitator Superfamily
B6V90_RS05535	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
B6V90_RS05545	COG1028	Short-chain dehydrogenase reductase Sdr
B6V90_RS05560	COG1113	amino acid transport
B6V90_RS05580	COG2837	iron assimilation
B6V90_RS05590	COG0270	DNA (cytosine-5-)-methyltransferase activity
B6V90_RS05625	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B6V90_RS05625	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B6V90_RS05635	COG0546	phosphoglycolate phosphatase activity
B6V90_RS05645	COG1570	exodeoxyribonuclease VII activity
B6V90_RS05655	COG1530	ribonuclease E activity
B6V90_RS05685	COG0768	penicillin binding
B6V90_RS05690	COG0772	Belongs to the SEDS family
B6V90_RS05700	COG0751	glycine-tRNA ligase activity
B6V90_RS05705	COG0752	glycyl-tRNA synthetase alpha subunit
B6V90_RS05725	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
B6V90_RS05730	COG3541	Predicted nucleotidyltransferase
B6V90_RS05735	COG0708	Exodeoxyribonuclease III
B6V90_RS05740	COG0316	Belongs to the HesB IscA family
B6V90_RS05745	COG0232	Belongs to the dGTPase family. Type 2 subfamily
B6V90_RS05750	COG0018	arginyl-trna synthetase
B6V90_RS05765	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
B6V90_RS05770	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B6V90_RS05775	COG0805	protein transport
B6V90_RS05780	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
B6V90_RS05790	COG0513	Belongs to the DEAD box helicase family
B6V90_RS05805	COG1289	transmembrane transporter activity
B6V90_RS05815	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
B6V90_RS05830	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B6V90_RS05840	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
B6V90_RS05845	COG0215	cysteine-tRNA ligase activity
B6V90_RS05875	COG2814	Major facilitator Superfamily
B6V90_RS05880	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
B6V90_RS05885	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
B6V90_RS05900	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
B6V90_RS05910	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
B6V90_RS05910	COG2885	chlorophyll binding
B6V90_RS05915	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
B6V90_RS05925	COG4974	Belongs to the 'phage' integrase family
B6V90_RS05930	COG0825	malonyl-CoA metabolic process
B6V90_RS05935	COG1546	Belongs to the CinA family
B6V90_RS05935	COG1058	Belongs to the CinA family
B6V90_RS05945	COG0494	nUDIX hydrolase
B6V90_RS05960	COG1862	Preprotein translocase
B6V90_RS05980	COG1758	RNA polymerase activity
B6V90_RS05985	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B6V90_RS05990	COG0736	holo-[acyl-carrier-protein] synthase activity
B6V90_RS05995	COG0681	Belongs to the peptidase S26 family
B6V90_RS06005	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
B6V90_RS06010	COG0528	UMP kinase activity
B6V90_RS06015	COG0233	cytoplasmic translational termination
B6V90_RS06020	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
B6V90_RS06030	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
B6V90_RS06035	COG0750	zinc metalloprotease
B6V90_RS06040	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B6V90_RS06050	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B6V90_RS06055	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B6V90_RS06060	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B6V90_RS06065	COG3494	Protein of unknown function (DUF1009)
B6V90_RS06070	COG0346	lactoylglutathione lyase activity
B6V90_RS06075	COG0230	Belongs to the bacterial ribosomal protein bL34 family
B6V90_RS06080	COG0594	ribonuclease P activity
B6V90_RS06085	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
B6V90_RS06090	COG0706	membrane insertase activity
B6V90_RS06095	COG0218	Necessary for normal cell division and for the maintenance of normal septation
B6V90_RS06100	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
B6V90_RS06105	COG2171	N-acyltransferase activity
B6V90_RS06110	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B6V90_RS06125	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
B6V90_RS06125	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
B6V90_RS06135	COG0101	tRNA pseudouridine synthase activity
B6V90_RS06140	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
B6V90_RS06145	COG0242	peptide deformylase activity
B6V90_RS06165	COG1137	ATPase activity
B6V90_RS06180	COG0517	IMP dehydrogenase activity
B6V90_RS06180	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
B6V90_RS06210	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
B6V90_RS06220	COG0556	nucleotide-excision repair
B6V90_RS06225	COG2017	converts alpha-aldose to the beta-anomer
B6V90_RS06235	COG0189	ligase activity
B6V90_RS06245	COG2226	methyltransferase
B6V90_RS06250	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B6V90_RS06255	COG0109	protoheme IX farnesyltransferase activity
B6V90_RS06265	COG0312	modulator of DNA gyrase
B6V90_RS06270	COG0612	Peptidase, M16
B6V90_RS06300	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
B6V90_RS06305	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
B6V90_RS06310	COG1956	GAF domain-containing protein
B6V90_RS06315	COG0728	peptidoglycan biosynthetic process
B6V90_RS06320	COG0386	Belongs to the glutathione peroxidase family
B6V90_RS06325	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
B6V90_RS06330	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
B6V90_RS06335	COG0181	hydroxymethylbilane synthase activity
B6V90_RS06345	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
B6V90_RS06360	COG2189	Belongs to the N(4) N(6)-methyltransferase family
B6V90_RS06375	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B6V90_RS06380	COG1120	ATPase activity
B6V90_RS06385	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
B6V90_RS06390	COG0408	coproporphyrinogen oxidase activity
B6V90_RS06395	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
B6V90_RS06405	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
B6V90_RS06410	COG0459	protein refolding
B6V90_RS06415	COG1199	ATP-dependent helicase activity
B6V90_RS06425	COG0392	lysyltransferase activity
B6V90_RS06435	COG0670	Belongs to the BI1 family
B6V90_RS06455	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
B6V90_RS06460	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
B6V90_RS06475	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
B6V90_RS06500	COG0488	(ABC) transporter
B6V90_RS06505	COG0105	UTP biosynthetic process
B6V90_RS06510	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
B6V90_RS06515	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
B6V90_RS06525	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
B6V90_RS06530	COG0248	Ppx GppA phosphatase
B6V90_RS06540	COG0019	diaminopimelate decarboxylase activity
B6V90_RS06560	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B6V90_RS06560	COG0519	Catalyzes the synthesis of GMP from XMP
B6V90_RS06565	COG0582	viral genome integration into host DNA
B6V90_RS06595	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
B6V90_RS06610	COG1196	nuclear chromosome segregation
B6V90_RS06625	COG0469	pyruvate kinase activity
B6V90_RS06630	COG0287	Prephenate dehydrogenase
B6V90_RS06640	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B6V90_RS06645	COG1215	transferase activity, transferring glycosyl groups
B6V90_RS06650	COG1562	ergosterol biosynthetic process
B6V90_RS06655	COG1562	ergosterol biosynthetic process
B6V90_RS06660	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
B6V90_RS06665	COG1657	PFAM Prenyltransferase squalene oxidase
B6V90_RS06675	COG0052	Belongs to the universal ribosomal protein uS2 family
B6V90_RS06680	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
B6V90_RS06685	COG1381	Involved in DNA repair and RecF pathway recombination
B6V90_RS06690	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
B6V90_RS06695	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B6V90_RS06705	COG0626	cystathionine gamma-synthase activity
B6V90_RS06715	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B6V90_RS06725	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
B6V90_RS06730	COG0077	Prephenate dehydratase
B6V90_RS06735	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B6V90_RS06740	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
B6V90_RS06750	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
B6V90_RS06755	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
B6V90_RS06765	COG1959	2 iron, 2 sulfur cluster binding
B6V90_RS06775	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
B6V90_RS06810	COG3263	regulation of cellular component size
B6V90_RS06830	COG0322	excinuclease ABC activity
B6V90_RS06835	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
B6V90_RS06845	COG0267	Belongs to the bacterial ribosomal protein bL33 family
B6V90_RS06855	COG0148	phosphopyruvate hydratase activity
B6V90_RS06865	COG2877	3-deoxy-8-phosphooctulonate synthase activity
B6V90_RS06870	COG0504	CTP synthase activity
B6V90_RS06880	COG0149	triose-phosphate isomerase activity
B6V90_RS06890	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B6V90_RS06900	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B6V90_RS06905	COG0134	indole-3-glycerol-phosphate synthase activity
B6V90_RS06910	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
B6V90_RS06915	COG0508	dehydrogenase complex catalyzes the overall conversion of
B6V90_RS06915	COG0022	dehydrogenase e1 component
B6V90_RS06920	COG0508	dehydrogenase complex catalyzes the overall conversion of
B6V90_RS06925	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B6V90_RS06930	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
B6V90_RS06935	COG2867	negative regulation of translational initiation
B6V90_RS06950	COG0861	Integral membrane protein TerC family
B6V90_RS06955	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
B6V90_RS06960	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
B6V90_RS06965	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B6V90_RS06975	COG0047	phosphoribosylformylglycinamidine synthase activity
B6V90_RS06980	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B6V90_RS06985	COG0271	Belongs to the BolA IbaG family
B6V90_RS06990	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
B6V90_RS07000	COG0792	nuclease activity
B6V90_RS07005	COG0113	porphobilinogen synthase activity
B6V90_RS07010	COG0531	amino acid
B6V90_RS07015	COG0531	amino acid
B6V90_RS07020	COG0531	amino acid
B6V90_RS07025	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B6V90_RS07030	COG0513	Belongs to the DEAD box helicase family
B6V90_RS07075	COG0673	inositol 2-dehydrogenase activity
B6V90_RS07080	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
B6V90_RS07085	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B6V90_RS07090	COG0154	amidase activity
B6V90_RS07095	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B6V90_RS07195	COG2814	Major facilitator Superfamily
B6V90_RS07215	COG0778	Nitroreductase
B6V90_RS07225	COG0135	phosphoribosylanthranilate isomerase activity
B6V90_RS07230	COG0284	orotidine-5'-phosphate decarboxylase activity
B6V90_RS07245	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B6V90_RS07250	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
B6V90_RS07255	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
B6V90_RS07270	COG0006	proline dipeptidase activity
B6V90_RS07275	COG2264	protein methyltransferase activity
B6V90_RS07280	COG0210	DNA helicase
B6V90_RS07290	COG2003	Belongs to the UPF0758 family
B6V90_RS07295	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
B6V90_RS07310	COG0254	rRNA binding
B6V90_RS07315	COG1970	mechanosensitive ion channel activity
B6V90_RS07330	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B6V90_RS07335	COG0673	inositol 2-dehydrogenase activity
B6V90_RS07345	COG0488	(ABC) transporter
B6V90_RS07350	COG4988	ABC transporter
B6V90_RS07355	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
B6V90_RS07375	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
B6V90_RS07380	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B6V90_RS07385	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
B6V90_RS07400	COG0837	glucose binding
B6V90_RS07415	COG0525	valine-tRNA ligase activity
B6V90_RS07420	COG0129	dihydroxy-acid dehydratase activity
B6V90_RS07425	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B6V90_RS07440	COG0756	dUTP diphosphatase activity
B6V90_RS07445	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
B6V90_RS07450	COG2226	methyltransferase
B6V90_RS07455	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B6V90_RS07460	COG0268	Binds directly to 16S ribosomal RNA
B6V90_RS07465	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
B6V90_RS07475	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
B6V90_RS07490	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
B6V90_RS07495	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B6V90_RS07515	COG0318	PFAM AMP-dependent synthetase and ligase
B6V90_RS07525	COG0156	8-amino-7-oxononanoate synthase activity
B6V90_RS07570	COG0483	inositol monophosphate 1-phosphatase activity
B6V90_RS07580	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
B6V90_RS07585	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B6V90_RS07590	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B6V90_RS07600	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
B6V90_RS07610	COG3590	peptidase
B6V90_RS07620	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
B6V90_RS07650	COG0354	folic acid binding
B6V90_RS07655	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
B6V90_RS07665	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
B6V90_RS07670	COG3781	membrane
B6V90_RS07675	COG1329	Transcriptional regulator
B6V90_RS07680	COG1028	Short-chain dehydrogenase reductase Sdr
B6V90_RS07685	COG2353	YceI-like domain
B6V90_RS07695	COG0729	surface antigen
B6V90_RS07705	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B6V90_RS07710	COG1702	phosphate starvation-inducible protein PhoH
B6V90_RS07715	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
B6V90_RS07725	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
B6V90_RS07730	COG1196	nuclear chromosome segregation
B6V90_RS07740	COG1605	Chorismate mutase
B6V90_RS07740	COG0287	Prephenate dehydrogenase
B6V90_RS07770	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
B6V90_RS07775	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
B6V90_RS07780	COG0142	geranyltranstransferase activity
B6V90_RS07790	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B6V90_RS07790	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
B6V90_RS07795	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
B6V90_RS07800	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
B6V90_RS07805	COG1519	Transferase
B6V90_RS07810	COG1663	tetraacyldisaccharide 4'-kinase activity
B6V90_RS07830	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
B6V90_RS07835	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
B6V90_RS07840	COG3572	ergothioneine biosynthetic process
B6V90_RS07850	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
B6V90_RS07855	COG2814	Major facilitator Superfamily
B6V90_RS07860	COG2814	Major facilitator Superfamily
B6V90_RS07865	COG1160	GTP binding
B6V90_RS07885	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B6V90_RS07895	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B6V90_RS07900	COG0237	dephospho-CoA kinase activity
B6V90_RS07905	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
B6V90_RS07915	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B6V90_RS07920	COG0165	Argininosuccinate lyase
B6V90_RS07935	COG0084	hydrolase, TatD family'
B6V90_RS07950	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
B6V90_RS07955	COG1686	Belongs to the peptidase S11 family
B6V90_RS07960	COG2951	lytic endotransglycosylase activity
B6V90_RS07975	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
B6V90_RS07980	COG1968	undecaprenyl-diphosphatase activity
B6V90_RS07985	COG0531	amino acid
B6V90_RS07990	COG0531	amino acid
B6V90_RS08010	COG2890	protein-(glutamine-N5) methyltransferase activity
B6V90_RS08020	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
B6V90_RS08025	COG0124	histidyl-tRNA synthetase
B6V90_RS08030	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
B6V90_RS08040	COG2070	2-Nitropropane dioxygenase
B6V90_RS08045	COG0527	aspartate kinase activity
B6V90_RS08050	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B6V90_RS08065	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
B6V90_RS08090	COG0321	lipoyl(octanoyl) transferase activity
B6V90_RS08105	COG0484	heat shock protein binding
B6V90_RS08130	COG1136	(ABC) transporter
B6V90_RS08140	COG0442	prolyl-tRNA aminoacylation
B6V90_RS08150	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
B6V90_RS08175	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
B6V90_RS08180	COG0740	serine-type endopeptidase activity
B6V90_RS08185	COG0544	peptidyl-prolyl cis-trans isomerase activity
B6V90_RS08195	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
B6V90_RS08195	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
B6V90_RS08205	COG0513	Belongs to the DEAD box helicase family
B6V90_RS08210	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B6V90_RS08215	COG0316	Belongs to the HesB IscA family
B6V90_RS08220	COG2151	metal-sulfur cluster biosynthetic enzyme
B6V90_RS08225	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B6V90_RS08230	COG0719	Fe-S assembly protein
B6V90_RS08235	COG0396	ATPase activity
B6V90_RS08240	COG0719	Fe-S assembly protein
B6V90_RS08250	COG2733	membrane
B6V90_RS08260	COG0038	chloride channel
B6V90_RS08265	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B6V90_RS08270	COG0227	Belongs to the bacterial ribosomal protein bL28 family
B6V90_RS08275	COG5265	(ABC) transporter
B6V90_RS08285	COG0628	permease
B6V90_RS08305	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B6V90_RS08310	COG0416	fatty acid biosynthetic process
B6V90_RS08315	COG0333	Belongs to the bacterial ribosomal protein bL32 family
B6V90_RS08335	COG0828	Belongs to the bacterial ribosomal protein bS21 family
B6V90_RS08345	COG1522	sequence-specific DNA binding
B6V90_RS08350	COG0492	ferredoxin-NADP+ reductase activity
B6V90_RS08355	COG0583	DNA-binding transcription factor activity
B6V90_RS08360	COG0776	regulation of translation
B6V90_RS08365	COG4957	zinc ion binding
B6V90_RS08370	COG1289	transmembrane transporter activity
B6V90_RS08380	COG0179	Fumarylacetoacetate (FAA) hydrolase
B6V90_RS08385	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
B6V90_RS08400	COG0261	This protein binds to 23S rRNA in the presence of protein L20
B6V90_RS08405	COG0211	Belongs to the bacterial ribosomal protein bL27 family
B6V90_RS08410	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
B6V90_RS08420	COG1139	Iron-sulfur cluster binding protein
B6V90_RS08425	COG0247	lactate metabolic process
B6V90_RS08445	COG3750	Belongs to the UPF0335 family
B6V90_RS08450	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
B6V90_RS08465	COG2001	Belongs to the MraZ family
B6V90_RS08470	COG0275	rRNA processing
B6V90_RS08480	COG0768	penicillin binding
B6V90_RS08485	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
B6V90_RS08490	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
B6V90_RS08495	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B6V90_RS08500	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
B6V90_RS08510	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B6V90_RS08515	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B6V90_RS08520	COG0812	UDP-N-acetylmuramate dehydrogenase activity
B6V90_RS08525	COG1181	Belongs to the D-alanine--D-alanine ligase family
B6V90_RS08530	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
B6V90_RS08535	COG0849	cell division
B6V90_RS08550	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B6V90_RS08555	COG0497	DNA recombination
B6V90_RS08560	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
B6V90_RS08575	COG1253	flavin adenine dinucleotide binding
B6V90_RS08615	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
B6V90_RS08630	COG0328	RNA-DNA hybrid ribonuclease activity
B6V90_RS08635	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
B6V90_RS08640	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
B6V90_RS08700	COG0436	Aminotransferase
B6V90_RS08705	COG0473	3-isopropylmalate dehydrogenase activity
B6V90_RS08710	COG0066	3-isopropylmalate dehydratase activity
B6V90_RS08715	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
B6V90_RS08720	COG0335	large ribosomal subunit rRNA binding
B6V90_RS08725	COG0336	Belongs to the RNA methyltransferase TrmD family
B6V90_RS08730	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
B6V90_RS08735	COG0228	four-way junction DNA binding
B6V90_RS08740	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
B6V90_RS08770	COG0513	Belongs to the DEAD box helicase family
B6V90_RS08775	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B6V90_RS08775	COG2813	Specifically methylates the guanine in position
B6V90_RS08780	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B6V90_RS08870	COG0784	Response regulator, receiver
B6V90_RS08870	COG4191	Histidine kinase
B6V90_RS08875	COG2166	iron-sulfur cluster assembly
B6V90_RS08885	COG4993	Dehydrogenase
B6V90_RS08890	COG0291	Belongs to the bacterial ribosomal protein bL35 family
B6V90_RS08895	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
B6V90_RS08900	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
B6V90_RS08905	COG0072	phenylalanine-tRNA ligase activity
B6V90_RS08905	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B6V90_RS08910	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B6V90_RS08915	COG0180	Tryptophanyl-tRNA synthetase
B6V90_RS08920	COG0545	Peptidyl-prolyl cis-trans isomerase
B6V90_RS08925	COG0137	argininosuccinate synthase activity
B6V90_RS08930	COG0820	rRNA (adenine-C2-)-methyltransferase activity
B6V90_RS08935	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
B6V90_RS08940	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
B6V90_RS08945	COG0142	geranyltranstransferase activity
B6V90_RS08950	COG1722	exodeoxyribonuclease VII activity
B6V90_RS08955	COG2252	PERMEase
B6V90_RS08965	COG0481	GTPase activity
B6V90_RS08985	COG0483	inositol monophosphate 1-phosphatase activity
B6V90_RS08990	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
B6V90_RS09040	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
B6V90_RS09045	COG1692	metallophosphoesterase
B6V90_RS09125	COG4993	Dehydrogenase