locus-tag	class	description
E2H97_RS00020	COG0187	DNA topoisomerase II activity
E2H97_RS00035	COG0751	glycine-tRNA ligase activity
E2H97_RS00040	COG0752	glycyl-tRNA synthetase alpha subunit
E2H97_RS00045	COG2818	Glycosylase
E2H97_RS00055	COG4946	Tricorn protease homolog
E2H97_RS00055	COG0823	Involved in the tonB-independent uptake of proteins
E2H97_RS00055	COG1506	peptidase
E2H97_RS00060	COG0425	Belongs to the sulfur carrier protein TusA family
E2H97_RS00070	COG1024	Enoyl-CoA hydratase
E2H97_RS00070	COG1250	3-hydroxyacyl-CoA dehydrogenase
E2H97_RS00080	COG1739	Uncharacterized protein family UPF0029
E2H97_RS00095	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E2H97_RS00100	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
E2H97_RS00125	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E2H97_RS00130	COG1063	alcohol dehydrogenase
E2H97_RS00145	COG1519	Transferase
E2H97_RS00150	COG3642	lipopolysaccharide core region biosynthetic process
E2H97_RS00155	COG0859	PFAM glycosyl transferase family 9
E2H97_RS00175	COG0204	Acyl-transferase
E2H97_RS00185	COG2095	MarC family integral membrane protein
E2H97_RS00190	COG3161	chorismate lyase activity
E2H97_RS00200	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
E2H97_RS00215	COG3031	protein transport across the cell outer membrane
E2H97_RS00225	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E2H97_RS00230	COG1459	type II secretion system
E2H97_RS00235	COG2165	general secretion pathway protein
E2H97_RS00245	COG2165	general secretion pathway protein
E2H97_RS00250	COG4795	General secretion pathway protein
E2H97_RS00255	COG3156	type II secretion system protein K
E2H97_RS00275	COG0840	transmembrane signaling receptor activity
E2H97_RS00285	COG1011	Hydrolase
E2H97_RS00290	COG0494	nUDIX hydrolase
E2H97_RS00295	COG1218	3'(2'),5'-bisphosphate nucleotidase
E2H97_RS00305	COG2814	Major facilitator Superfamily
E2H97_RS00340	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E2H97_RS00370	COG1253	flavin adenine dinucleotide binding
E2H97_RS00410	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E2H97_RS00415	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
E2H97_RS00415	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
E2H97_RS00445	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E2H97_RS00455	COG0501	Belongs to the peptidase M48B family
E2H97_RS00460	COG4269	membrane
E2H97_RS00465	COG1309	transcriptional regulator
E2H97_RS00475	COG2234	aminopeptidase activity
E2H97_RS00480	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E2H97_RS00485	COG0250	Participates in transcription elongation, termination and antitermination
E2H97_RS00490	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
E2H97_RS00495	COG0081	regulation of translation
E2H97_RS00500	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
E2H97_RS00505	COG0222	ribosome binding
E2H97_RS00530	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
E2H97_RS00535	COG0049	tRNA binding
E2H97_RS00540	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E2H97_RS00545	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E2H97_RS00565	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E2H97_RS00570	COG0300	oxidoreductase activity
E2H97_RS00575	COG0583	DNA-binding transcription factor activity
E2H97_RS00580	COG3038	cytochrome b561
E2H97_RS00610	COG1840	ABC-type Fe3 transport system, periplasmic component
E2H97_RS00615	COG4149	molybdate abc transporter
E2H97_RS00620	COG3842	ATPase activity
E2H97_RS00625	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E2H97_RS00650	COG3078	GTPase activator activity
E2H97_RS00660	COG0218	Necessary for normal cell division and for the maintenance of normal septation
E2H97_RS00665	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E2H97_RS00665	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E2H97_RS00670	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
E2H97_RS00685	COG3678	ATP-independent chaperone mediated protein folding
E2H97_RS00690	COG0745	RESPONSE REGULATOR receiver
E2H97_RS00695	COG2205	protein histidine kinase activity
E2H97_RS00710	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
E2H97_RS00740	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E2H97_RS00745	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
E2H97_RS00750	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E2H97_RS00755	COG2264	protein methyltransferase activity
E2H97_RS00765	COG3118	belongs to the thioredoxin family
E2H97_RS00775	COG0248	Ppx GppA phosphatase
E2H97_RS00785	COG0668	transmembrane transport
E2H97_RS00790	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
E2H97_RS00810	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E2H97_RS00820	COG0746	molybdenum cofactor guanylyltransferase activity
E2H97_RS00825	COG1022	Amp-dependent synthetase and ligase
E2H97_RS00860	COG0521	Mo-molybdopterin cofactor biosynthetic process
E2H97_RS00865	COG4221	oxidoreductase activity
E2H97_RS00875	COG1032	radical SAM domain protein
E2H97_RS00925	COG0204	Acyl-transferase
E2H97_RS00930	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
E2H97_RS00935	COG3706	GGDEF domain
E2H97_RS00940	COG2201	protein-glutamate methylesterase activity
E2H97_RS00955	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
E2H97_RS00970	COG1028	Short-chain dehydrogenase reductase Sdr
E2H97_RS01015	COG4991	sh3 domain protein
E2H97_RS01015	COG3064	Membrane
E2H97_RS01015	COG0515	serine threonine protein kinase
E2H97_RS01020	COG0534	Mate efflux family protein
E2H97_RS01025	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E2H97_RS01030	COG0459	protein refolding
E2H97_RS01050	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E2H97_RS01055	COG0569	domain protein
E2H97_RS01060	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E2H97_RS01060	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E2H97_RS01070	COG0242	peptide deformylase activity
E2H97_RS01080	COG0758	DNA mediated transformation
E2H97_RS01085	COG2922	Belongs to the Smg family
E2H97_RS01090	COG0823	Involved in the tonB-independent uptake of proteins
E2H97_RS01215	COG3291	Pkd domain containing protein
E2H97_RS01220	COG0551	DNA topoisomerase type I activity
E2H97_RS01225	COG0009	L-threonylcarbamoyladenylate synthase
E2H97_RS01230	COG0408	coproporphyrinogen oxidase activity
E2H97_RS01240	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E2H97_RS01250	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
E2H97_RS01285	COG0456	acetyltransferase
E2H97_RS01295	COG1295	ribonuclease BN
E2H97_RS01310	COG0564	pseudouridine synthase activity
E2H97_RS01315	COG1227	inorganic diphosphatase activity
E2H97_RS01320	COG1028	Short-chain dehydrogenase reductase Sdr
E2H97_RS01325	COG0174	glutamine synthetase
E2H97_RS01330	COG1217	gtp-binding protein TYPA
E2H97_RS01340	COG0151	Belongs to the GarS family
E2H97_RS01345	COG0138	bifunctional purine biosynthesis protein purh
E2H97_RS01350	COG0789	Transcriptional regulator
E2H97_RS01355	COG0701	Predicted permease
E2H97_RS01370	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E2H97_RS01375	COG2183	response to ionizing radiation
E2H97_RS01385	COG0596	Alpha beta hydrolase
E2H97_RS01390	COG1040	competence protein
E2H97_RS01395	COG4989	oxidoreductase activity
E2H97_RS01400	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
E2H97_RS01405	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
E2H97_RS01420	COG5007	Belongs to the BolA IbaG family
E2H97_RS01430	COG2854	intermembrane phospholipid transfer
E2H97_RS01435	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E2H97_RS01440	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E2H97_RS01445	COG1127	ABC transporter
E2H97_RS01455	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
E2H97_RS01470	COG1137	ATPase activity
E2H97_RS01475	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
E2H97_RS01485	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E2H97_RS01495	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E2H97_RS01515	COG1011	Hydrolase
E2H97_RS01520	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
E2H97_RS01530	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
E2H97_RS01535	COG0019	diaminopimelate decarboxylase activity
E2H97_RS01550	COG3072	Adenylate cyclase
E2H97_RS01555	COG0181	hydroxymethylbilane synthase activity
E2H97_RS01565	COG2959	enzyme of heme biosynthesis
E2H97_RS01585	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E2H97_RS01605	COG2203	Gaf domain
E2H97_RS01605	COG2200	EAL domain
E2H97_RS01605	COG2199	diguanylate cyclase activity
E2H97_RS01615	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
E2H97_RS01625	COG3591	Belongs to the peptidase S1B family
E2H97_RS01625	COG4990	cell redox homeostasis
E2H97_RS01635	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E2H97_RS01665	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E2H97_RS01685	COG2847	Copper chaperone PCu(A)C
E2H97_RS01700	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E2H97_RS01705	COG0584	glycerophosphoryl diester phosphodiesterase
E2H97_RS01710	COG1511	domain protein
E2H97_RS01710	COG3264	Mechanosensitive ion channel
E2H97_RS01715	COG0688	phosphatidylethanolamine metabolic process
E2H97_RS01720	COG1162	GTPase activity
E2H97_RS01745	COG2311	Membrane
E2H97_RS01760	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E2H97_RS01765	COG2197	response regulator
E2H97_RS01770	COG4585	Histidine kinase
E2H97_RS01790	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
E2H97_RS01820	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
E2H97_RS01835	COG0338	D12 class N6 adenine-specific DNA methyltransferase
E2H97_RS01850	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E2H97_RS01860	COG0180	Tryptophanyl-tRNA synthetase
E2H97_RS01870	COG2203	Gaf domain
E2H97_RS01870	COG5001	Diguanylate cyclase
E2H97_RS01870	COG4251	negative regulation of phosphorylation
E2H97_RS01870	COG3706	GGDEF domain
E2H97_RS01880	COG2165	general secretion pathway protein
E2H97_RS01895	COG0251	oxidation-reduction process
E2H97_RS01900	COG2823	Periplasmic or secreted lipoprotein
E2H97_RS01905	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
E2H97_RS01920	COG0792	nuclease activity
E2H97_RS01925	COG3107	peptidoglycan biosynthetic process
E2H97_RS01930	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
E2H97_RS01940	COG1566	PFAM secretion protein HlyD family protein
E2H97_RS01970	COG0583	DNA-binding transcription factor activity
E2H97_RS02000	COG2814	Major facilitator Superfamily
E2H97_RS02005	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E2H97_RS02025	COG0513	Belongs to the DEAD box helicase family
E2H97_RS02100	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E2H97_RS02105	COG0640	Transcriptional regulator
E2H97_RS02110	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E2H97_RS02135	COG2814	Major facilitator Superfamily
E2H97_RS02150	COG0840	transmembrane signaling receptor activity
E2H97_RS02155	COG0493	'glutamate synthase
E2H97_RS02185	COG4232	protein-disulfide reductase activity
E2H97_RS02190	COG1324	tolerance protein
E2H97_RS02195	COG3030	protein affecting phage T7 exclusion by the F plasmid
E2H97_RS02210	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E2H97_RS02215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E2H97_RS02295	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
E2H97_RS02315	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
E2H97_RS02320	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
E2H97_RS02325	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
E2H97_RS02330	COG0557	exoribonuclease II activity
E2H97_RS02340	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E2H97_RS02345	COG0360	Binds together with S18 to 16S ribosomal RNA
E2H97_RS02355	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E2H97_RS02360	COG0359	binds to the 23S rRNA
E2H97_RS02370	COG1752	Esterase of the alpha-beta hydrolase superfamily
E2H97_RS02375	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
E2H97_RS02380	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E2H97_RS02385	COG0018	arginyl-trna synthetase
E2H97_RS02390	COG1794	racemase activity, acting on amino acids and derivatives
E2H97_RS02410	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E2H97_RS02415	COG0254	rRNA binding
E2H97_RS02420	COG0281	malic enzyme
E2H97_RS02425	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E2H97_RS02430	COG0076	glutamate decarboxylase activity
E2H97_RS02490	COG3267	Type II secretory pathway component ExeA
E2H97_RS02490	COG3409	Peptidoglycan-binding domain 1 protein
E2H97_RS02500	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E2H97_RS02505	COG1459	type II secretion system
E2H97_RS02515	COG2165	general secretion pathway protein
E2H97_RS02520	COG2165	general secretion pathway protein
E2H97_RS02525	COG4968	Prepilin-type N-terminal cleavage methylation domain
E2H97_RS02560	COG1077	Cell shape determining protein MreB Mrl
E2H97_RS02565	COG1792	Involved in formation and maintenance of cell shape
E2H97_RS02570	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
E2H97_RS02575	COG0424	maF-like protein
E2H97_RS02580	COG1530	ribonuclease E activity
E2H97_RS02585	COG3164	Protein of unknown function
E2H97_RS02590	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E2H97_RS02595	COG0312	modulator of DNA gyrase
E2H97_RS02605	COG4774	siderophore transport
E2H97_RS02605	COG1629	transport
E2H97_RS02620	COG3028	Belongs to the UPF0307 family
E2H97_RS02625	COG0312	modulator of DNA gyrase
E2H97_RS02630	COG0666	response to abiotic stimulus
E2H97_RS02640	COG2133	pyrroloquinoline quinone binding
E2H97_RS02665	COG2828	Protein conserved in bacteria
E2H97_RS02670	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
E2H97_RS02675	COG0372	Belongs to the citrate synthase family
E2H97_RS02680	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
E2H97_RS02685	COG1802	Transcriptional regulator
E2H97_RS02690	COG0204	Acyl-transferase
E2H97_RS02695	COG0204	Acyl-transferase
E2H97_RS02700	COG0606	chelatase, subunit chli
E2H97_RS02710	COG0737	Belongs to the 5'-nucleotidase family
E2H97_RS02730	COG0795	lipopolysaccharide-transporting ATPase activity
E2H97_RS02735	COG0795	lipopolysaccharide-transporting ATPase activity
E2H97_RS02740	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E2H97_RS02750	COG2356	endonuclease I
E2H97_RS02775	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E2H97_RS02780	COG0189	ligase activity
E2H97_RS02785	COG1785	Belongs to the alkaline phosphatase family
E2H97_RS02805	COG0191	fructose-bisphosphate aldolase activity
E2H97_RS02810	COG0126	phosphoglycerate kinase activity
E2H97_RS02815	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E2H97_RS02825	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E2H97_RS02840	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
E2H97_RS02855	COG5001	Diguanylate cyclase
E2H97_RS02855	COG3706	GGDEF domain
E2H97_RS02855	COG4251	negative regulation of phosphorylation
E2H97_RS02855	COG2203	Gaf domain
E2H97_RS02870	COG0805	protein transport
E2H97_RS02875	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E2H97_RS02880	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E2H97_RS02885	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
E2H97_RS02895	COG2226	methyltransferase
E2H97_RS02900	COG0010	Belongs to the arginase family
E2H97_RS02905	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E2H97_RS02905	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E2H97_RS02935	COG0513	Belongs to the DEAD box helicase family
E2H97_RS02940	COG0006	proline dipeptidase activity
E2H97_RS02950	COG0006	proline dipeptidase activity
E2H97_RS02955	COG0545	Peptidyl-prolyl cis-trans isomerase
E2H97_RS02960	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E2H97_RS02965	COG3097	Belongs to the UPF0267 family
E2H97_RS02985	COG2050	protein possibly involved in aromatic compounds catabolism
E2H97_RS02995	COG0814	amino acid
E2H97_RS03010	COG1757	Na H antiporter
E2H97_RS03020	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E2H97_RS03025	COG0163	prenyltransferase activity
E2H97_RS03035	COG1131	(ABC) transporter
E2H97_RS03040	COG0842	Transport permease protein
E2H97_RS03055	COG2927	DNA polymerase III (CHI subunit)
E2H97_RS03060	COG0525	valine-tRNA ligase activity
E2H97_RS03080	COG0802	atpase or kinase
E2H97_RS03085	COG0860	N-Acetylmuramoyl-L-alanine amidase
E2H97_RS03090	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
E2H97_RS03100	COG1923	regulation of RNA biosynthetic process
E2H97_RS03105	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E2H97_RS03110	COG0330	HflC and HflK could
E2H97_RS03115	COG0330	HflC and HflK could
E2H97_RS03120	COG0723	plastoquinol--plastocyanin reductase activity
E2H97_RS03125	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
E2H97_RS03130	COG2857	Cytochrome c1
E2H97_RS03135	COG0625	glutathione transferase activity
E2H97_RS03140	COG2969	positive regulation of protein catabolic process
E2H97_RS03145	COG3706	GGDEF domain
E2H97_RS03165	COG0626	cystathionine gamma-synthase activity
E2H97_RS03175	COG3300	MHYT domain
E2H97_RS03175	COG5001	Diguanylate cyclase
E2H97_RS03180	COG1185	polyribonucleotide nucleotidyltransferase activity
E2H97_RS03190	COG4785	May be involved in cell division
E2H97_RS03205	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
E2H97_RS03210	COG0084	hydrolase, TatD family'
E2H97_RS03215	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E2H97_RS03225	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
E2H97_RS03230	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
E2H97_RS03235	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
E2H97_RS03240	COG0813	purine-nucleoside phosphorylase activity
E2H97_RS03245	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
E2H97_RS03250	COG0560	Phosphoserine phosphatase
E2H97_RS03290	COG4988	ABC transporter
E2H97_RS03295	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
E2H97_RS03315	COG2166	iron-sulfur cluster assembly
E2H97_RS03320	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E2H97_RS03325	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E2H97_RS03330	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E2H97_RS03335	COG0745	RESPONSE REGULATOR receiver
E2H97_RS03345	COG0527	aspartate kinase activity
E2H97_RS03360	COG2990	Protein conserved in bacteria
E2H97_RS03370	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E2H97_RS03375	COG1643	Atp-dependent helicase
E2H97_RS03390	COG1489	DNA binding
E2H97_RS03400	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E2H97_RS03410	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E2H97_RS03415	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
E2H97_RS03420	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E2H97_RS03430	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
E2H97_RS03440	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
E2H97_RS03445	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E2H97_RS03455	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E2H97_RS03460	COG0840	transmembrane signaling receptor activity
E2H97_RS03480	COG3610	response to peptide
E2H97_RS03485	COG2966	Psort location CytoplasmicMembrane, score
E2H97_RS03495	COG0211	Belongs to the bacterial ribosomal protein bL27 family
E2H97_RS03500	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E2H97_RS03505	COG0142	geranyltranstransferase activity
E2H97_RS03510	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
E2H97_RS03515	COG1280	lysine exporter protein (LysE YggA)
E2H97_RS03530	COG4807	Protein conserved in bacteria
E2H97_RS03535	COG0281	malic enzyme
E2H97_RS03540	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
E2H97_RS03565	COG4974	Belongs to the 'phage' integrase family
E2H97_RS03590	COG3634	alkyl hydroperoxide reductase activity
E2H97_RS03595	COG0450	alkyl hydroperoxide reductase
E2H97_RS03620	COG0582	viral genome integration into host DNA
E2H97_RS03655	COG0270	DNA (cytosine-5-)-methyltransferase activity
E2H97_RS03665	COG4245	von Willebrand factor, type A
E2H97_RS03740	COG1686	Belongs to the peptidase S11 family
E2H97_RS03745	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E2H97_RS03750	COG2951	lytic endotransglycosylase activity
E2H97_RS03755	COG0772	Belongs to the SEDS family
E2H97_RS03760	COG0768	penicillin binding
E2H97_RS03765	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
E2H97_RS03770	COG0799	negative regulation of ribosome biogenesis
E2H97_RS03785	COG0813	purine-nucleoside phosphorylase activity
E2H97_RS03840	COG1288	antiporter activity
E2H97_RS03865	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
E2H97_RS03870	COG1466	dna polymerase III delta subunit
E2H97_RS03875	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
E2H97_RS03905	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E2H97_RS03910	COG4535	Mg2 and Co2 transporter CorC
E2H97_RS03915	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
E2H97_RS03920	COG1702	phosphate starvation-inducible protein PhoH
E2H97_RS03925	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E2H97_RS03935	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E2H97_RS03985	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E2H97_RS03990	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
E2H97_RS03995	COG3083	sulfuric ester hydrolase activity
E2H97_RS04005	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
E2H97_RS04010	COG1570	exodeoxyribonuclease VII activity
E2H97_RS04015	COG0367	asparagine synthase
E2H97_RS04035	COG0516	GMP reductase activity
E2H97_RS04035	COG0517	IMP dehydrogenase activity
E2H97_RS04040	COG0519	Catalyzes the synthesis of GMP from XMP
E2H97_RS04040	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E2H97_RS04070	COG0217	transcriptional regulatory protein
E2H97_RS04090	COG1067	ATP-dependent peptidase activity
E2H97_RS04095	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E2H97_RS04100	COG0471	metal ion transport
E2H97_RS04105	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E2H97_RS04145	COG1404	Belongs to the peptidase S8 family
E2H97_RS04175	COG0366	Alpha amylase catalytic
E2H97_RS04180	COG1609	Transcriptional regulator
E2H97_RS04185	COG0366	Alpha amylase catalytic
E2H97_RS04185	COG1874	Beta-galactosidase
E2H97_RS04195	COG1501	Belongs to the glycosyl hydrolase 31 family
E2H97_RS04200	COG1523	belongs to the glycosyl hydrolase 13 family
E2H97_RS04210	COG0366	Alpha amylase catalytic
E2H97_RS04215	COG1940	carbohydrate kinase activity
E2H97_RS04250	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E2H97_RS04260	COG1595	DNA-templated transcription, initiation
E2H97_RS04265	COG3712	iron ion homeostasis
E2H97_RS04290	COG0848	biopolymer transport protein
E2H97_RS04310	COG2867	negative regulation of translational initiation
E2H97_RS04315	COG2914	Belongs to the UPF0125 (RnfH) family
E2H97_RS04320	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E2H97_RS04335	COG2203	Gaf domain
E2H97_RS04335	COG2199	diguanylate cyclase activity
E2H97_RS04360	COG0820	rRNA (adenine-C2-)-methyltransferase activity
E2H97_RS04365	COG3063	Type IV pilus biogenesis stability protein PilW
E2H97_RS04375	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
E2H97_RS04380	COG0124	histidyl-tRNA synthetase
E2H97_RS04385	COG2976	Protein conserved in bacteria
E2H97_RS04390	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E2H97_RS04395	COG1160	GTP binding
E2H97_RS04405	COG0500	methyltransferase
E2H97_RS04435	COG0348	domain, Protein
E2H97_RS04435	COG3901	Regulator of nitric oxide reductase transcription
E2H97_RS04460	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E2H97_RS04465	COG0142	geranyltranstransferase activity
E2H97_RS04470	COG1722	exodeoxyribonuclease VII activity
E2H97_RS04475	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E2H97_RS04480	COG1360	Flagellar Motor Protein
E2H97_RS04480	COG1360	Flagellar Motor Protein
E2H97_RS04495	COG0443	Heat shock 70 kDa protein
E2H97_RS04520	COG1944	ATP diphosphatase activity
E2H97_RS04530	COG0583	DNA-binding transcription factor activity
E2H97_RS04540	COG2363	Small membrane protein
E2H97_RS04545	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
E2H97_RS04570	COG0473	3-isopropylmalate dehydrogenase activity
E2H97_RS04575	COG4946	Tricorn protease homolog
E2H97_RS04575	COG1506	peptidase
E2H97_RS04575	COG0823	Involved in the tonB-independent uptake of proteins
E2H97_RS04590	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E2H97_RS04595	COG1611	Belongs to the LOG family
E2H97_RS04655	COG1252	NADH dehydrogenase
E2H97_RS04680	COG1454	alcohol dehydrogenase
E2H97_RS04690	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E2H97_RS04705	COG0826	peptidase U32
E2H97_RS04710	COG5001	Diguanylate cyclase
E2H97_RS04735	COG0488	(ABC) transporter
E2H97_RS04755	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E2H97_RS04755	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E2H97_RS04770	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
E2H97_RS04775	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E2H97_RS04780	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
E2H97_RS04785	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
E2H97_RS04795	COG0497	DNA recombination
E2H97_RS04815	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E2H97_RS04820	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E2H97_RS04825	COG3956	TIGRFAM MazG family protein
E2H97_RS04850	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
E2H97_RS04855	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E2H97_RS04860	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E2H97_RS04865	COG0137	argininosuccinate synthase activity
E2H97_RS04880	COG2897	thiosulfate sulfurtransferase activity
E2H97_RS04885	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
E2H97_RS04915	COG2198	Histidine kinase
E2H97_RS04915	COG0784	Response regulator, receiver
E2H97_RS04915	COG5002	protein histidine kinase activity
E2H97_RS04945	COG0683	leucine binding
E2H97_RS04950	COG0410	ABC transporter
E2H97_RS04960	COG1733	regulation of RNA biosynthetic process
E2H97_RS04965	COG2249	NAD(P)H dehydrogenase (quinone) activity
E2H97_RS04970	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E2H97_RS04970	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E2H97_RS04975	COG0509	glycine decarboxylation via glycine cleavage system
E2H97_RS04980	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E2H97_RS04985	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E2H97_RS04990	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E2H97_RS05030	COG0693	protein deglycase activity
E2H97_RS05040	COG0277	FAD linked oxidase domain protein
E2H97_RS05045	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
E2H97_RS05055	COG0493	'glutamate synthase
E2H97_RS05060	COG0070	glutamate synthase
E2H97_RS05060	COG0069	glutamate synthase activity
E2H97_RS05060	COG0067	glutamate synthase
E2H97_RS05065	COG4206	TonB-dependent receptor
E2H97_RS05080	COG0739	heme binding
E2H97_RS05085	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E2H97_RS05100	COG4771	TonB-dependent receptor
E2H97_RS05125	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
E2H97_RS05145	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
E2H97_RS05160	COG3026	antisigma factor binding
E2H97_RS05165	COG3086	response to oxidative stress
E2H97_RS05170	COG0481	GTPase activity
E2H97_RS05175	COG0681	Belongs to the peptidase S26 family
E2H97_RS05185	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
E2H97_RS05190	COG1381	Involved in DNA repair and RecF pathway recombination
E2H97_RS05200	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
E2H97_RS05220	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E2H97_RS05225	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E2H97_RS05235	COG0762	integral membrane protein
E2H97_RS05240	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
E2H97_RS05260	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
E2H97_RS05270	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
E2H97_RS05275	COG1678	Uncharacterized ACR, COG1678
E2H97_RS05280	COG0023	Translation Initiation Factor
E2H97_RS05295	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
E2H97_RS05310	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E2H97_RS05315	COG1757	Na H antiporter
E2H97_RS05325	COG1194	a g-specific adenine glycosylase
E2H97_RS05330	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E2H97_RS05340	COG0583	DNA-binding transcription factor activity
E2H97_RS05355	COG0004	ammonium transporteR
E2H97_RS05360	COG0583	DNA-binding transcription factor activity
E2H97_RS05380	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
E2H97_RS05410	COG4536	flavin adenine dinucleotide binding
E2H97_RS05415	COG4137	Cytochrome C assembly protein
E2H97_RS05420	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E2H97_RS05425	COG0228	four-way junction DNA binding
E2H97_RS05430	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
E2H97_RS05435	COG0336	Belongs to the RNA methyltransferase TrmD family
E2H97_RS05440	COG0335	large ribosomal subunit rRNA binding
E2H97_RS05445	COG0287	Prephenate dehydrogenase
E2H97_RS05445	COG1605	Chorismate mutase
E2H97_RS05455	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
E2H97_RS05470	COG2169	Transcriptional regulator
E2H97_RS05470	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E2H97_RS05485	COG0166	Belongs to the GPI family
E2H97_RS05495	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E2H97_RS05505	COG1238	metal cluster binding
E2H97_RS05510	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
E2H97_RS05515	COG1115	amino acid carrier protein
E2H97_RS05520	COG3022	response to hydroperoxide
E2H97_RS05550	COG0268	Binds directly to 16S ribosomal RNA
E2H97_RS05555	COG0728	peptidoglycan biosynthetic process
E2H97_RS05560	COG0196	riboflavin kinase activity
E2H97_RS05570	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
E2H97_RS05575	COG1047	Peptidyl-prolyl cis-trans
E2H97_RS05580	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
E2H97_RS05615	COG3104	oligopeptide transport
E2H97_RS05620	COG0250	Participates in transcription elongation, termination and antitermination
E2H97_RS05625	COG1596	polysaccharide export
E2H97_RS05640	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
E2H97_RS05690	COG0367	asparagine synthase
E2H97_RS05700	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E2H97_RS05705	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E2H97_RS05725	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E2H97_RS05730	COG5433	transposase activity
E2H97_RS05765	COG0582	viral genome integration into host DNA
E2H97_RS05815	COG2337	Toxic component of a toxin-antitoxin (TA) module
E2H97_RS05840	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E2H97_RS05860	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E2H97_RS05925	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E2H97_RS05930	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E2H97_RS05970	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E2H97_RS06000	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E2H97_RS06020	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E2H97_RS06045	COG0625	glutathione transferase activity
E2H97_RS06055	COG1301	dicarboxylic acid transport
E2H97_RS06060	COG2918	glutathione biosynthetic process
E2H97_RS06075	COG2203	Gaf domain
E2H97_RS06075	COG2199	diguanylate cyclase activity
E2H97_RS06080	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
E2H97_RS06085	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
E2H97_RS06105	COG0745	RESPONSE REGULATOR receiver
E2H97_RS06110	COG5002	protein histidine kinase activity
E2H97_RS06120	COG0386	Belongs to the glutathione peroxidase family
E2H97_RS06130	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E2H97_RS06130	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E2H97_RS06135	COG1115	amino acid carrier protein
E2H97_RS06150	COG0583	DNA-binding transcription factor activity
E2H97_RS06165	COG0625	glutathione transferase activity
E2H97_RS06170	COG0564	pseudouridine synthase activity
E2H97_RS06185	COG1136	(ABC) transporter
E2H97_RS06185	COG0577	efflux transmembrane transporter activity
E2H97_RS06195	COG2204	response regulator
E2H97_RS06200	COG5002	protein histidine kinase activity
E2H97_RS06205	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E2H97_RS06220	COG0343	queuine tRNA-ribosyltransferase activity
E2H97_RS06225	COG1862	Preprotein translocase
E2H97_RS06230	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E2H97_RS06235	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E2H97_RS06255	COG2067	long-chain fatty acid transport protein
E2H97_RS06260	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E2H97_RS06270	COG2171	N-acyltransferase activity
E2H97_RS06285	COG0024	Methionine aminopeptidase
E2H97_RS06290	COG0052	Belongs to the universal ribosomal protein uS2 family
E2H97_RS06295	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
E2H97_RS06305	COG0233	cytoplasmic translational termination
E2H97_RS06310	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E2H97_RS06315	COG0575	Belongs to the CDS family
E2H97_RS06325	COG0750	zinc metalloprotease
E2H97_RS06335	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
E2H97_RS06345	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E2H97_RS06350	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E2H97_RS06355	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E2H97_RS06370	COG0037	tRNA processing
E2H97_RS06390	COG3604	Transcriptional regulator
E2H97_RS06395	COG0840	transmembrane signaling receptor activity
E2H97_RS06400	COG1104	cysteine desulfurase activity
E2H97_RS06405	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E2H97_RS06420	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E2H97_RS06425	COG4106	trans-aconitate 2-methyltransferase activity
E2H97_RS06445	COG2350	Protein conserved in bacteria
E2H97_RS06450	COG2917	probably involved in intracellular septation
E2H97_RS06455	COG3098	single-species biofilm formation
E2H97_RS06460	COG0564	pseudouridine synthase activity
E2H97_RS06465	COG0716	FMN binding
E2H97_RS06490	COG0513	Belongs to the DEAD box helicase family
E2H97_RS06495	COG0513	Belongs to the DEAD box helicase family
E2H97_RS06515	COG3620	sequence-specific DNA binding
E2H97_RS06535	COG3115	cell septum assembly
E2H97_RS06540	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E2H97_RS06560	COG2199	diguanylate cyclase activity
E2H97_RS06575	COG0442	prolyl-tRNA aminoacylation
E2H97_RS06585	COG0110	maltose O-acetyltransferase activity
E2H97_RS06595	COG1720	tRNA m6t6A37 methyltransferase activity
E2H97_RS06605	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E2H97_RS06640	COG1757	Na H antiporter
E2H97_RS06645	COG1435	thymidine kinase activity
E2H97_RS06655	COG3201	nicotinamide mononucleotide transporter
E2H97_RS06695	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E2H97_RS06705	COG4638	Rieske (2fe-2S)
E2H97_RS06710	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E2H97_RS06730	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E2H97_RS06735	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E2H97_RS06740	COG0215	cysteine-tRNA ligase activity
E2H97_RS06745	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
E2H97_RS06770	COG0740	serine-type endopeptidase activity
E2H97_RS06780	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E2H97_RS06790	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E2H97_RS06805	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E2H97_RS06810	COG4172	Belongs to the ABC transporter superfamily
E2H97_RS06820	COG4171	peptide transport system, permease
E2H97_RS06825	COG0601	transmembrane transport
E2H97_RS06830	COG0747	negative chemotaxis
E2H97_RS06835	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
E2H97_RS06840	COG1842	Phage shock protein A
E2H97_RS06850	COG1983	PspC domain protein
E2H97_RS06855	COG3106	COG3106 Predicted ATPase
E2H97_RS06860	COG3768	UPF0283 membrane protein
E2H97_RS06875	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E2H97_RS06880	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E2H97_RS06895	COG0285	dihydrofolate synthase activity
E2H97_RS06900	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
E2H97_RS06905	COG1286	toxin biosynthetic process
E2H97_RS06910	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
E2H97_RS06920	COG0179	Fumarylacetoacetate (FAA) hydrolase
E2H97_RS06960	COG1349	DNA-binding transcription factor activity
E2H97_RS06970	COG2222	sugar isomerase
E2H97_RS06975	COG1940	carbohydrate kinase activity
E2H97_RS07000	COG2070	2-Nitropropane dioxygenase
E2H97_RS07000	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
E2H97_RS07005	COG0300	oxidoreductase activity
E2H97_RS07005	COG4221	oxidoreductase activity
E2H97_RS07005	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E2H97_RS07005	COG3321	synthase
E2H97_RS07025	COG2091	lysine biosynthetic process via aminoadipic acid
E2H97_RS07035	COG4771	TonB-dependent receptor
E2H97_RS07050	COG1429	ligase activity, forming nitrogen-metal bonds
E2H97_RS07075	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
E2H97_RS07120	COG0159	tryptophan synthase activity
E2H97_RS07125	COG0133	tryptophan synthase activity
E2H97_RS07130	COG0134	indole-3-glycerol-phosphate synthase activity
E2H97_RS07130	COG0135	phosphoribosylanthranilate isomerase activity
E2H97_RS07135	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E2H97_RS07140	COG0512	Glutamine amidotransferase of anthranilate synthase
E2H97_RS07145	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E2H97_RS07155	COG0564	pseudouridine synthase activity
E2H97_RS07185	COG5433	transposase activity
E2H97_RS07275	COG0625	glutathione transferase activity
E2H97_RS07290	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E2H97_RS07345	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E2H97_RS07350	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
E2H97_RS07360	COG4770	biotin carboxylase activity
E2H97_RS07365	COG1024	Enoyl-CoA hydratase
E2H97_RS07370	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E2H97_RS07375	COG1960	acyl-CoA dehydrogenase activity
E2H97_RS07385	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
E2H97_RS07390	COG1575	Belongs to the MenA family. Type 1 subfamily
E2H97_RS07395	COG1946	Acyl-CoA thioesterase
E2H97_RS07415	COG3047	cAMP biosynthetic process
E2H97_RS07430	COG1760	l-serine dehydratase
E2H97_RS07435	COG1472	Belongs to the glycosyl hydrolase 3 family
E2H97_RS07470	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
E2H97_RS07495	COG4591	ABC-type transport system involved in lipoprotein release permease component
E2H97_RS07505	COG0456	acetyltransferase
E2H97_RS07525	COG2333	competence protein COMEC
E2H97_RS07525	COG0658	competence protein
E2H97_RS07530	COG1132	(ABC) transporter
E2H97_RS07535	COG1663	tetraacyldisaccharide 4'-kinase activity
E2H97_RS07540	COG2835	tetraacyldisaccharide 4'-kinase activity
E2H97_RS07560	COG0612	Peptidase, M16
E2H97_RS07565	COG0372	Belongs to the citrate synthase family
E2H97_RS07575	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
E2H97_RS07580	COG1053	succinate dehydrogenase
E2H97_RS07590	COG0567	Dehydrogenase, E1 component
E2H97_RS07595	COG0508	dehydrogenase complex catalyzes the overall conversion of
E2H97_RS07600	COG0045	succinate-CoA ligase (ADP-forming) activity
E2H97_RS07605	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E2H97_RS07610	COG0598	Magnesium transport protein CorA
E2H97_RS07630	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
E2H97_RS07670	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E2H97_RS07680	COG1012	belongs to the aldehyde dehydrogenase family
E2H97_RS07685	COG3938	Belongs to the proline racemase family
E2H97_RS07690	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E2H97_RS07695	COG3938	Belongs to the proline racemase family
E2H97_RS07715	COG0405	Gamma-glutamyltransferase
E2H97_RS07740	COG1999	signal sequence binding
E2H97_RS07760	COG1045	serine acetyltransferase
E2H97_RS07765	COG1959	2 iron, 2 sulfur cluster binding
E2H97_RS07770	COG1104	cysteine desulfurase activity
E2H97_RS07775	COG0822	iron-sulfur transferase activity
E2H97_RS07780	COG0316	Belongs to the HesB IscA family
E2H97_RS07790	COG0443	Heat shock 70 kDa protein
E2H97_RS07820	COG4181	ATPase activity
E2H97_RS07825	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
E2H97_RS07830	COG1090	epimerase
E2H97_RS07835	COG0628	permease
E2H97_RS07840	COG0084	hydrolase, TatD family'
E2H97_RS07845	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E2H97_RS07845	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
E2H97_RS07855	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
E2H97_RS07860	COG3008	intermembrane lipid transfer
E2H97_RS07865	COG2995	paraquat-inducible protein a
E2H97_RS07870	COG2995	paraquat-inducible protein a
E2H97_RS07875	COG3141	response to X-ray
E2H97_RS07880	COG1956	GAF domain-containing protein
E2H97_RS07885	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
E2H97_RS07890	COG0793	Belongs to the peptidase S41A family
E2H97_RS07895	COG0308	aminopeptidase N
E2H97_RS07900	COG0460	homoserine dehydrogenase
E2H97_RS07900	COG0527	aspartate kinase activity
E2H97_RS07910	COG2902	Dehydrogenase
E2H97_RS07915	COG0167	dihydroorotate dehydrogenase activity
E2H97_RS07925	COG3104	oligopeptide transport
E2H97_RS07955	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
E2H97_RS07955	COG0116	Belongs to the methyltransferase superfamily
E2H97_RS07965	COG0488	(ABC) transporter
E2H97_RS07980	COG3130	regulation of translation
E2H97_RS07985	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E2H97_RS07990	COG1067	ATP-dependent peptidase activity
E2H97_RS08015	COG2197	response regulator
E2H97_RS08025	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E2H97_RS08050	COG2996	Protein conserved in bacteria
E2H97_RS08055	COG1166	arginine decarboxylase activity
E2H97_RS08065	COG0010	Belongs to the arginase family
E2H97_RS08070	COG0259	pyridoxamine-phosphate oxidase activity
E2H97_RS08105	COG0716	FMN binding
E2H97_RS08120	COG0596	Alpha beta hydrolase
E2H97_RS08125	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
E2H97_RS08130	COG0033	Phosphoglucomutase
E2H97_RS08145	COG2226	methyltransferase
E2H97_RS08150	COG3706	GGDEF domain
E2H97_RS08160	COG0217	transcriptional regulatory protein
E2H97_RS08165	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
E2H97_RS08170	COG0632	four-way junction helicase activity
E2H97_RS08175	COG2255	four-way junction helicase activity
E2H97_RS08180	COG0346	lactoylglutathione lyase activity
E2H97_RS08190	COG0583	DNA-binding transcription factor activity
E2H97_RS08195	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E2H97_RS08205	COG4659	FMN binding
E2H97_RS08210	COG4658	electron transport chain
E2H97_RS08220	COG2878	Part of a membrane complex involved in electron transport
E2H97_RS08225	COG4657	Part of a membrane complex involved in electron transport
E2H97_RS08290	COG1506	peptidase
E2H97_RS08290	COG0823	Involved in the tonB-independent uptake of proteins
E2H97_RS08310	COG1448	Aminotransferase
E2H97_RS08315	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E2H97_RS08325	COG0539	negative regulation of cytoplasmic translation
E2H97_RS08330	COG0776	regulation of translation
E2H97_RS08340	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
E2H97_RS08345	COG0284	orotidine-5'-phosphate decarboxylase activity
E2H97_RS08350	COG3122	Protein conserved in bacteria
E2H97_RS08360	COG1393	Belongs to the ArsC family
E2H97_RS08365	COG4783	chaperone-mediated protein folding
E2H97_RS08380	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E2H97_RS08385	COG2716	regulation of RNA biosynthetic process
E2H97_RS08395	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
E2H97_RS08400	COG1214	PFAM Peptidase M22, glycoprotease
E2H97_RS08410	COG2267	carboxylic ester hydrolase activity
E2H97_RS08415	COG0318	PFAM AMP-dependent synthetase and ligase
E2H97_RS08420	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
E2H97_RS08425	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
E2H97_RS08430	COG2894	cell division
E2H97_RS08440	COG3100	YcgL domain-containing protein
E2H97_RS08450	COG2983	Belongs to the UPF0260 family
E2H97_RS08455	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
E2H97_RS08460	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E2H97_RS08465	COG2186	Transcriptional regulator
E2H97_RS08470	COG2719	SpoVR family
E2H97_RS08475	COG2718	Belongs to the UPF0229 family
E2H97_RS08480	COG2766	serine protein kinase
E2H97_RS08485	COG2193	ferroxidase activity
E2H97_RS08495	COG2906	2 iron, 2 sulfur cluster binding
E2H97_RS08505	COG2329	Antibiotic biosynthesis monooxygenase
E2H97_RS08510	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E2H97_RS08515	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E2H97_RS08590	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
E2H97_RS08595	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E2H97_RS08600	COG0175	sulfate reduction
E2H97_RS08605	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E2H97_RS08605	COG1648	precorrin-2 dehydrogenase activity
E2H97_RS08610	COG0175	sulfate reduction
E2H97_RS08615	COG2895	sulfate adenylyltransferase (ATP) activity
E2H97_RS08620	COG3273	potassium ion transport
E2H97_RS08620	COG0471	metal ion transport
E2H97_RS08625	COG0529	Catalyzes the synthesis of activated sulfate
E2H97_RS08670	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
E2H97_RS08680	COG3278	Belongs to the heme-copper respiratory oxidase family
E2H97_RS08695	COG2010	Cytochrome c
E2H97_RS08705	COG2217	Heavy metal translocating P-type atpase
E2H97_RS08720	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E2H97_RS08725	COG0589	response to stress
E2H97_RS08730	COG0037	tRNA processing
E2H97_RS08770	COG0840	transmembrane signaling receptor activity
E2H97_RS08775	COG1757	Na H antiporter
E2H97_RS08780	COG1960	acyl-CoA dehydrogenase activity
E2H97_RS08795	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
E2H97_RS08835	COG0583	DNA-binding transcription factor activity
E2H97_RS08840	COG0670	Belongs to the BI1 family
E2H97_RS08845	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
E2H97_RS08850	COG2923	Belongs to the DsrF TusC family
E2H97_RS08860	COG2920	part of a sulfur-relay system
E2H97_RS08870	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E2H97_RS08880	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E2H97_RS08885	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
E2H97_RS08890	COG0531	amino acid
E2H97_RS08890	COG1674	ftsk spoiiie
E2H97_RS08900	COG0686	Belongs to the AlaDH PNT family
E2H97_RS08905	COG0492	ferredoxin-NADP+ reductase activity
E2H97_RS08910	COG1199	ATP-dependent helicase activity
E2H97_RS08925	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E2H97_RS08940	COG0517	IMP dehydrogenase activity
E2H97_RS08940	COG0617	tRNA 3'-terminal CCA addition
E2H97_RS08940	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
E2H97_RS08955	COG0121	glutamine amidotransferase
E2H97_RS08995	COG0454	-acetyltransferase
E2H97_RS09025	COG2211	Major facilitator Superfamily
E2H97_RS09065	COG3451	type IV secretory pathway VirB4
E2H97_RS09085	COG3736	Type IV secretory pathway, component VirB8
E2H97_RS09100	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
E2H97_RS09140	COG1132	(ABC) transporter
E2H97_RS09200	COG1028	Short-chain dehydrogenase reductase Sdr
E2H97_RS09355	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
E2H97_RS09410	COG5433	transposase activity
E2H97_RS09470	COG5433	transposase activity
E2H97_RS09475	COG2801	Transposase and inactivated derivatives
E2H97_RS09515	COG2801	Transposase and inactivated derivatives
E2H97_RS09525	COG0662	Cupin 2, conserved barrel domain protein
E2H97_RS09540	COG2826	transposase and inactivated derivatives, IS30 family
E2H97_RS09545	COG2963	transposase activity
E2H97_RS09580	COG0109	protoheme IX farnesyltransferase activity
E2H97_RS09585	COG1612	heme a metabolic process
E2H97_RS09605	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
E2H97_RS09610	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E2H97_RS09615	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E2H97_RS09615	COG1565	acr, cog1565
E2H97_RS09630	COG3148	PFAM DTW domain containing protein
E2H97_RS09635	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E2H97_RS09645	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E2H97_RS09665	COG1393	Belongs to the ArsC family
E2H97_RS09675	COG1876	peptidase activity
E2H97_RS09680	COG0288	reversible hydration of carbon dioxide
E2H97_RS09685	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
E2H97_RS09710	COG2715	membrane protein required for spore maturation
E2H97_RS09715	COG1643	Atp-dependent helicase
E2H97_RS09725	COG2911	Protein conserved in bacteria
E2H97_RS09730	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
E2H97_RS09735	COG1505	serine-type exopeptidase activity
E2H97_RS09755	COG0776	regulation of translation
E2H97_RS09760	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E2H97_RS09760	COG0072	phenylalanine-tRNA ligase activity
E2H97_RS09790	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
E2H97_RS09795	COG0291	Belongs to the bacterial ribosomal protein bL35 family
E2H97_RS09800	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
E2H97_RS09805	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E2H97_RS09815	COG0307	riboflavin synthase, alpha
E2H97_RS09835	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
E2H97_RS09845	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E2H97_RS09855	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E2H97_RS09860	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E2H97_RS09865	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E2H97_RS09875	COG0446	pyridine nucleotide-disulphide oxidoreductase
E2H97_RS09875	COG1902	pentaerythritol trinitrate reductase activity
E2H97_RS09880	COG0616	signal peptide processing
E2H97_RS09885	COG0252	asparaginase activity
E2H97_RS09900	COG1012	belongs to the aldehyde dehydrogenase family
E2H97_RS09900	COG1454	alcohol dehydrogenase
E2H97_RS09905	COG1757	Na H antiporter
E2H97_RS09920	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E2H97_RS09925	COG0328	RNA-DNA hybrid ribonuclease activity
E2H97_RS09930	COG2226	methyltransferase
E2H97_RS09935	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E2H97_RS09960	COG2022	thiamine diphosphate biosynthetic process
E2H97_RS09970	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E2H97_RS09975	COG0352	thiamine-phosphate diphosphorylase activity
E2H97_RS09980	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
E2H97_RS10020	COG0484	heat shock protein binding
E2H97_RS10070	COG0488	(ABC) transporter
E2H97_RS10075	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E2H97_RS10080	COG1061	Type III restriction enzyme res subunit
E2H97_RS10085	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
E2H97_RS10090	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
E2H97_RS10095	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
E2H97_RS10100	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E2H97_RS10105	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
E2H97_RS10105	COG0131	Imidazoleglycerol-phosphate dehydratase
E2H97_RS10110	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
E2H97_RS10120	COG0107	imidazoleglycerol-phosphate synthase activity
E2H97_RS10125	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
E2H97_RS10125	COG0140	phosphoribosyl-ATP diphosphatase activity
E2H97_RS10205	COG0582	viral genome integration into host DNA
E2H97_RS10240	COG4628	conserved protein (DUF2132)
E2H97_RS10305	COG0501	Belongs to the peptidase M48B family
E2H97_RS10325	COG0022	dehydrogenase e1 component
E2H97_RS10345	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E2H97_RS10350	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
E2H97_RS10370	COG0076	glutamate decarboxylase activity
E2H97_RS10385	COG2873	o-acetylhomoserine
E2H97_RS10395	COG2258	MOSC domain
E2H97_RS10405	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E2H97_RS10410	COG0318	PFAM AMP-dependent synthetase and ligase
E2H97_RS10415	COG0596	Alpha beta hydrolase
E2H97_RS10420	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E2H97_RS10440	COG1028	Short-chain dehydrogenase reductase Sdr
E2H97_RS10450	COG1024	Enoyl-CoA hydratase
E2H97_RS10455	COG1024	Enoyl-CoA hydratase
E2H97_RS10460	COG1960	acyl-CoA dehydrogenase activity
E2H97_RS10490	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E2H97_RS10495	COG4935	Belongs to the peptidase S8 family
E2H97_RS10495	COG2234	aminopeptidase activity
E2H97_RS10540	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
E2H97_RS10545	COG0470	DNA polymerase III
E2H97_RS10555	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E2H97_RS10560	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E2H97_RS10565	COG0717	Belongs to the dCTP deaminase family
E2H97_RS10570	COG0572	uridine kinase
E2H97_RS10575	COG0489	protein tyrosine kinase activity
E2H97_RS10590	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
E2H97_RS10605	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
E2H97_RS10615	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
E2H97_RS10620	COG0542	response to heat
E2H97_RS10625	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
E2H97_RS10630	COG1278	Cold shock
E2H97_RS10660	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E2H97_RS10670	COG2850	peptidyl-arginine hydroxylation
E2H97_RS10705	COG0277	FAD linked oxidase domain protein
E2H97_RS10705	COG0247	lactate metabolic process
E2H97_RS10725	COG0573	inorganic phosphate transmembrane transporter activity
E2H97_RS10760	COG3240	lipase activity
E2H97_RS10785	COG1131	(ABC) transporter
E2H97_RS10795	COG1278	Cold shock
E2H97_RS10800	COG2226	methyltransferase
E2H97_RS10830	COG0492	ferredoxin-NADP+ reductase activity
E2H97_RS10845	COG2226	methyltransferase
E2H97_RS10855	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E2H97_RS10860	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
E2H97_RS10910	COG3384	dioxygenase
E2H97_RS10940	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E2H97_RS10945	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E2H97_RS10960	COG1414	Transcriptional regulator
E2H97_RS10965	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E2H97_RS10970	COG1940	carbohydrate kinase activity
E2H97_RS10975	COG0363	glucosamine-6-phosphate deaminase activity
E2H97_RS10980	COG4154	Belongs to the RbsD FucU family
E2H97_RS10985	COG0179	Fumarylacetoacetate (FAA) hydrolase
E2H97_RS10990	COG1028	Short-chain dehydrogenase reductase Sdr
E2H97_RS11005	COG1304	FMN binding
E2H97_RS11010	COG4948	Mandelate Racemase Muconate Lactonizing
E2H97_RS11025	COG0673	inositol 2-dehydrogenase activity
E2H97_RS11040	COG2925	Exonuclease
E2H97_RS11045	COG0295	cytidine deaminase activity
E2H97_RS11050	COG0295	cytidine deaminase activity
E2H97_RS11060	COG2084	Dehydrogenase
E2H97_RS11065	COG1070	Carbohydrate kinase
E2H97_RS11090	COG3487	Iron-regulated protein
E2H97_RS11095	COG1730	sister chromatid segregation
E2H97_RS11105	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E2H97_RS11110	COG1136	(ABC) transporter
E2H97_RS11115	COG1136	(ABC) transporter
E2H97_RS11115	COG0577	efflux transmembrane transporter activity
E2H97_RS11125	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E2H97_RS11130	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E2H97_RS11135	COG1028	Short-chain dehydrogenase reductase Sdr
E2H97_RS11140	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
E2H97_RS11145	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E2H97_RS11150	COG0416	fatty acid biosynthetic process
E2H97_RS11155	COG0333	Belongs to the bacterial ribosomal protein bL32 family
E2H97_RS11160	COG1399	metal-binding, possibly nucleic acid-binding protein
E2H97_RS11165	COG0424	maF-like protein
E2H97_RS11175	COG1530	ribonuclease E activity
E2H97_RS11180	COG0659	secondary active sulfate transmembrane transporter activity
E2H97_RS11190	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E2H97_RS11210	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
E2H97_RS11215	COG1074	ATP-dependent DNA helicase activity
E2H97_RS11220	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E2H97_RS11235	COG1181	Belongs to the D-alanine--D-alanine ligase family
E2H97_RS11270	COG4946	Tricorn protease homolog
E2H97_RS11270	COG0793	Belongs to the peptidase S41A family
E2H97_RS11280	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E2H97_RS11285	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E2H97_RS11285	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E2H97_RS11295	COG3005	denitrification pathway
E2H97_RS11300	COG3043	anaerobic respiration
E2H97_RS11305	COG0243	molybdopterin cofactor binding
E2H97_RS11310	COG3062	negative regulation of establishment of protein localization
E2H97_RS11315	COG4459	periplasmic nitrate reductase
E2H97_RS11320	COG3005	denitrification pathway
E2H97_RS11325	COG3043	anaerobic respiration
E2H97_RS11330	COG0243	molybdopterin cofactor binding
E2H97_RS11335	COG3062	negative regulation of establishment of protein localization
E2H97_RS11340	COG4459	periplasmic nitrate reductase
E2H97_RS11365	COG0574	Belongs to the PEP-utilizing enzyme family
E2H97_RS11365	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E2H97_RS11370	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
E2H97_RS11425	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
E2H97_RS11430	COG2885	chlorophyll binding
E2H97_RS11435	COG0823	Involved in the tonB-independent uptake of proteins
E2H97_RS11450	COG0811	peptide transport
E2H97_RS11455	COG0824	Thioesterase
E2H97_RS11460	COG2885	chlorophyll binding
E2H97_RS11470	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E2H97_RS11480	COG0450	alkyl hydroperoxide reductase
E2H97_RS11485	COG2056	Na+-H+ antiporter family
E2H97_RS11495	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
E2H97_RS11500	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
E2H97_RS11505	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E2H97_RS11515	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E2H97_RS11520	COG2885	chlorophyll binding
E2H97_RS11520	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
E2H97_RS11525	COG0745	RESPONSE REGULATOR receiver
E2H97_RS11530	COG0642	Histidine kinase
E2H97_RS11535	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
E2H97_RS11540	COG0248	Ppx GppA phosphatase
E2H97_RS11555	COG2814	Major facilitator Superfamily
E2H97_RS11560	COG0737	Belongs to the 5'-nucleotidase family
E2H97_RS11565	COG0531	amino acid
E2H97_RS11570	COG0737	Belongs to the 5'-nucleotidase family
E2H97_RS11580	COG2165	general secretion pathway protein
E2H97_RS11600	COG0330	HflC and HflK could
E2H97_RS11615	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
E2H97_RS11695	COG0739	heme binding
E2H97_RS11695	COG0741	lytic transglycosylase activity
E2H97_RS11695	COG1196	nuclear chromosome segregation
E2H97_RS11705	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E2H97_RS11720	COG3081	Nucleoid-associated protein
E2H97_RS11725	COG3082	Protein of unknown function (DUF1414)
E2H97_RS11735	COG0432	Pfam Uncharacterised protein family UPF0047
E2H97_RS11740	COG2951	lytic endotransglycosylase activity
E2H97_RS11755	COG0784	Response regulator, receiver
E2H97_RS11755	COG0835	chemotaxis
E2H97_RS11760	COG2226	methyltransferase
E2H97_RS11765	COG0077	Prephenate dehydratase
E2H97_RS11765	COG1605	Chorismate mutase
E2H97_RS11780	COG1960	acyl-CoA dehydrogenase activity
E2H97_RS11785	COG0800	Aldolase
E2H97_RS11790	COG0129	dihydroxy-acid dehydratase activity
E2H97_RS11795	COG0363	glucosamine-6-phosphate deaminase activity
E2H97_RS11800	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
E2H97_RS11805	COG1737	Transcriptional regulator
E2H97_RS11810	COG0469	pyruvate kinase activity
E2H97_RS11820	COG1960	acyl-CoA dehydrogenase activity
E2H97_RS11840	COG3012	SEC-C Motif Domain Protein
E2H97_RS11890	COG0602	queuosine metabolic process
E2H97_RS11900	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
E2H97_RS11915	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
E2H97_RS11925	COG0583	DNA-binding transcription factor activity
E2H97_RS11930	COG0556	nucleotide-excision repair
E2H97_RS11950	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
E2H97_RS11970	COG3139	Protein of unknown function (DUF1315)
E2H97_RS11980	COG2866	Carboxypeptidase
E2H97_RS11985	COG1448	Aminotransferase
E2H97_RS12010	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E2H97_RS12025	COG1322	Protein conserved in bacteria
E2H97_RS12040	COG0537	adenosine 5'-monophosphoramidase activity
E2H97_RS12045	COG1414	Transcriptional regulator
E2H97_RS12050	COG0280	phosphate acetyltransferase
E2H97_RS12055	COG0730	response to heat
E2H97_RS12080	COG2855	membrane
E2H97_RS12095	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E2H97_RS12100	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E2H97_RS12105	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E2H97_RS12105	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E2H97_RS12130	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E2H97_RS12135	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E2H97_RS12150	COG1492	cobalamin metabolic process
E2H97_RS12160	COG2115	Belongs to the xylose isomerase family
E2H97_RS12165	COG2814	Major facilitator Superfamily
E2H97_RS12165	COG0477	Major facilitator Superfamily
E2H97_RS12170	COG2207	Transcriptional regulator
E2H97_RS12170	COG1609	Transcriptional regulator
E2H97_RS12175	COG1070	Carbohydrate kinase
E2H97_RS12190	COG0501	Belongs to the peptidase M48B family
E2H97_RS12210	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E2H97_RS12215	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
E2H97_RS12220	COG2226	methyltransferase
E2H97_RS12225	COG0156	8-amino-7-oxononanoate synthase activity
E2H97_RS12235	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E2H97_RS12240	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
E2H97_RS12245	COG0735	belongs to the Fur family
E2H97_RS12260	COG0616	signal peptide processing
E2H97_RS12270	COG1028	Short-chain dehydrogenase reductase Sdr
E2H97_RS12280	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E2H97_RS12285	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
E2H97_RS12295	COG0009	L-threonylcarbamoyladenylate synthase
E2H97_RS12300	COG0613	PHP domain protein
E2H97_RS12340	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
E2H97_RS12345	COG0006	proline dipeptidase activity
E2H97_RS12355	COG0456	acetyltransferase
E2H97_RS12365	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E2H97_RS12370	COG0583	DNA-binding transcription factor activity
E2H97_RS12375	COG0583	DNA-binding transcription factor activity
E2H97_RS12385	COG0778	Nitroreductase
E2H97_RS12430	COG1882	Formate acetyltransferase
E2H97_RS12435	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E2H97_RS12440	COG3092	negative regulation of chromosome organization
E2H97_RS12445	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E2H97_RS12470	COG0393	Putative heavy-metal-binding
E2H97_RS12485	COG0010	Belongs to the arginase family
E2H97_RS12495	COG1301	dicarboxylic acid transport
E2H97_RS12500	COG0471	metal ion transport
E2H97_RS12505	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E2H97_RS12525	COG0563	adenylate kinase activity
E2H97_RS12530	COG3118	belongs to the thioredoxin family
E2H97_RS12535	COG0326	Molecular chaperone. Has ATPase activity
E2H97_RS12545	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E2H97_RS12550	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
E2H97_RS12560	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E2H97_RS12570	COG2066	Belongs to the glutaminase family
E2H97_RS12580	COG3220	belongs to the UPF0276 family
E2H97_RS12590	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E2H97_RS12605	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E2H97_RS12610	COG3102	Protein conserved in bacteria
E2H97_RS12620	COG2770	Histidine kinase
E2H97_RS12620	COG3437	response regulator, receiver
E2H97_RS12640	COG0339	signal peptide processing
E2H97_RS12650	COG2194	sulfuric ester hydrolase activity
E2H97_RS12655	COG0471	metal ion transport
E2H97_RS12665	COG0583	DNA-binding transcription factor activity
E2H97_RS12685	COG0129	dihydroxy-acid dehydratase activity
E2H97_RS12690	COG0028	Belongs to the TPP enzyme family
E2H97_RS12700	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
E2H97_RS12705	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E2H97_RS12710	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E2H97_RS12720	COG0602	queuosine metabolic process
E2H97_RS12725	COG1328	CTP reductase activity
E2H97_RS12735	COG2130	NADP-dependent
E2H97_RS12755	COG0513	Belongs to the DEAD box helicase family
E2H97_RS12765	COG2194	sulfuric ester hydrolase activity
E2H97_RS12775	COG0419	ATPase involved in DNA repair
E2H97_RS12780	COG0420	3'-5' exonuclease activity
E2H97_RS12785	COG0730	response to heat
E2H97_RS12825	COG0848	biopolymer transport protein
E2H97_RS12830	COG0811	peptide transport
E2H97_RS12835	COG0811	peptide transport
E2H97_RS12860	COG0417	DNA replication proofreading
E2H97_RS12865	COG1199	ATP-dependent helicase activity
E2H97_RS12905	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E2H97_RS12910	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E2H97_RS12935	COG2890	protein-(glutamine-N5) methyltransferase activity
E2H97_RS12940	COG2840	Smr protein MutS2
E2H97_RS12945	COG2062	phosphohistidine phosphatase, SixA
E2H97_RS12950	COG1025	Belongs to the peptidase M16 family
E2H97_RS12955	COG3300	MHYT domain
E2H97_RS12955	COG5001	Diguanylate cyclase
E2H97_RS12970	COG0183	Belongs to the thiolase family
E2H97_RS12975	COG0714	Associated with various cellular activities
E2H97_RS13005	COG1595	DNA-templated transcription, initiation
E2H97_RS13020	COG2824	Alkylphosphonate utilization operon protein PhnA
E2H97_RS13035	COG1132	(ABC) transporter
E2H97_RS13070	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
E2H97_RS13075	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E2H97_RS13080	COG2137	regulation of response to DNA damage stimulus
E2H97_RS13085	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
E2H97_RS13110	COG1388	LysM domain
E2H97_RS13110	COG4942	peptidase
E2H97_RS13115	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
E2H97_RS13130	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
E2H97_RS13135	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
E2H97_RS13140	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
E2H97_RS13150	COG0504	CTP synthase activity
E2H97_RS13185	COG1516	flagellar protein fliS
E2H97_RS13205	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E2H97_RS13225	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E2H97_RS13240	COG3951	Flagellar rod assembly protein muramidase FlgJ
E2H97_RS13240	COG1705	Flagellar rod assembly protein muramidase FlgJ
E2H97_RS13245	COG1706	bacterial-type flagellum-dependent cell motility
E2H97_RS13250	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
E2H97_RS13260	COG4787	bacterial-type flagellum-dependent cell motility
E2H97_RS13280	COG1749	Flagellar hook protein flgE
E2H97_RS13295	COG1815	bacterial-type flagellum-dependent cell motility
E2H97_RS13300	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
E2H97_RS13305	COG0835	chemotaxis
E2H97_RS13305	COG0784	Response regulator, receiver
E2H97_RS13360	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
E2H97_RS13365	COG2853	Lipoprotein
E2H97_RS13375	COG0835	chemotaxis
E2H97_RS13385	COG1192	Involved in chromosome partitioning
E2H97_RS13395	COG2201	protein-glutamate methylesterase activity
E2H97_RS13400	COG0643	Histidine kinase
E2H97_RS13400	COG0784	Response regulator, receiver
E2H97_RS13400	COG2198	Histidine kinase
E2H97_RS13405	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
E2H97_RS13455	COG4221	oxidoreductase activity
E2H97_RS13465	COG3806	Anti-sigma factor
E2H97_RS13470	COG1595	DNA-templated transcription, initiation
E2H97_RS13490	COG1684	flagellar biosynthetic protein fliR
E2H97_RS13495	COG1987	bacterial-type flagellum assembly
E2H97_RS13545	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E2H97_RS13555	COG1677	Flagellar hook-basal body complex protein FliE
E2H97_RS13585	COG0066	3-isopropylmalate dehydratase activity
E2H97_RS13590	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
E2H97_RS13595	COG0473	3-isopropylmalate dehydrogenase activity
E2H97_RS13600	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E2H97_RS13615	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E2H97_RS13620	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E2H97_RS13630	COG3152	Membrane
E2H97_RS13645	COG3272	Protein of unknown function (DUF1722)
E2H97_RS13650	COG0415	Belongs to the DNA photolyase family
E2H97_RS13675	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
E2H97_RS13725	COG1247	-acetyltransferase
E2H97_RS13730	COG2165	general secretion pathway protein
E2H97_RS13740	COG0542	response to heat
E2H97_RS13760	COG0564	pseudouridine synthase activity
E2H97_RS13765	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E2H97_RS13805	COG5492	domain, Protein
E2H97_RS13805	COG4932	domain protein
E2H97_RS13810	COG0577	efflux transmembrane transporter activity
E2H97_RS13810	COG1136	(ABC) transporter
E2H97_RS13815	COG1136	(ABC) transporter
E2H97_RS13815	COG0577	efflux transmembrane transporter activity
E2H97_RS13820	COG1136	(ABC) transporter
E2H97_RS13835	COG1115	amino acid carrier protein
E2H97_RS13845	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E2H97_RS13860	COG0477	Major facilitator Superfamily
E2H97_RS13880	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
E2H97_RS13885	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
E2H97_RS13890	COG0730	response to heat
E2H97_RS13900	COG0494	nUDIX hydrolase
E2H97_RS13915	COG0583	DNA-binding transcription factor activity
E2H97_RS13920	COG5002	protein histidine kinase activity
E2H97_RS13920	COG2198	Histidine kinase
E2H97_RS13920	COG0784	Response regulator, receiver
E2H97_RS13925	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E2H97_RS13950	COG1560	Kdo2-lipid A biosynthetic process
E2H97_RS13955	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
E2H97_RS13955	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
E2H97_RS13970	COG0500	methyltransferase
E2H97_RS14020	COG0193	aminoacyl-tRNA hydrolase activity
E2H97_RS14035	COG1012	belongs to the aldehyde dehydrogenase family
E2H97_RS14045	COG4771	TonB-dependent receptor
E2H97_RS14055	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
E2H97_RS14060	COG2354	Protein conserved in bacteria
E2H97_RS14070	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
E2H97_RS14080	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E2H97_RS14105	COG0540	Belongs to the ATCase OTCase family
E2H97_RS14110	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E2H97_RS14120	COG3266	domain, Protein
E2H97_RS14125	COG3267	Type II secretory pathway component ExeA
E2H97_RS14125	COG3409	Peptidoglycan-binding domain 1 protein
E2H97_RS14130	COG0617	tRNA 3'-terminal CCA addition
E2H97_RS14140	COG1968	undecaprenyl-diphosphatase activity
E2H97_RS14145	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
E2H97_RS14150	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
E2H97_RS14155	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
E2H97_RS14170	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
E2H97_RS14175	COG0828	Belongs to the bacterial ribosomal protein bS21 family
E2H97_RS14180	COG1610	YqeY-like protein
E2H97_RS14185	COG0358	DNA primase activity
E2H97_RS14190	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E2H97_RS14215	COG1960	acyl-CoA dehydrogenase activity
E2H97_RS14225	COG3313	Fe-S protein
E2H97_RS14230	COG0271	Belongs to the BolA IbaG family
E2H97_RS14260	COG0583	DNA-binding transcription factor activity
E2H97_RS14280	COG0456	acetyltransferase
E2H97_RS14285	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E2H97_RS14295	COG2921	Belongs to the UPF0250 family
E2H97_RS14300	COG2267	carboxylic ester hydrolase activity
E2H97_RS14335	COG3154	lipid carrier protein
E2H97_RS14340	COG0826	peptidase U32
E2H97_RS14345	COG0826	peptidase U32
E2H97_RS14355	COG4968	Prepilin-type N-terminal cleavage methylation domain
E2H97_RS14360	COG0405	Gamma-glutamyltransferase
E2H97_RS14370	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E2H97_RS14380	COG1301	dicarboxylic acid transport
E2H97_RS14415	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
E2H97_RS14420	COG0545	Peptidyl-prolyl cis-trans isomerase
E2H97_RS14450	COG0484	heat shock protein binding
E2H97_RS14465	COG2252	PERMEase
E2H97_RS14475	COG2195	Cleaves the N-terminal amino acid of tripeptides
E2H97_RS14500	COG1454	alcohol dehydrogenase
E2H97_RS14515	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
E2H97_RS14530	COG2991	Protein conserved in bacteria
E2H97_RS14535	COG1477	protein flavinylation
E2H97_RS14540	COG2871	sodium ion transport
E2H97_RS14545	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
E2H97_RS14550	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
E2H97_RS14555	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
E2H97_RS14560	COG1805	sodium ion transport
E2H97_RS14565	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
E2H97_RS14570	COG0564	pseudouridine synthase activity
E2H97_RS14575	COG2234	aminopeptidase activity
E2H97_RS14585	COG1376	ErfK ybiS ycfS ynhG family protein
E2H97_RS14590	COG0577	efflux transmembrane transporter activity
E2H97_RS14590	COG1136	(ABC) transporter
E2H97_RS14610	COG0641	radical SAM
E2H97_RS14620	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
E2H97_RS14625	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E2H97_RS14630	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
E2H97_RS14650	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
E2H97_RS14655	COG0840	transmembrane signaling receptor activity
E2H97_RS14660	COG3314	Sporulation integral membrane protein YlbJ
E2H97_RS14680	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E2H97_RS14690	COG1846	Transcriptional regulator
E2H97_RS14695	COG1012	belongs to the aldehyde dehydrogenase family
E2H97_RS14740	COG1476	TRANSCRIPTIONal
E2H97_RS14760	COG1294	oxidase, subunit
E2H97_RS14780	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E2H97_RS14785	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
E2H97_RS14790	COG0488	(ABC) transporter
E2H97_RS14800	COG0429	hydrolase of the alpha beta-hydrolase fold
E2H97_RS14805	COG3089	Belongs to the UPF0270 family
E2H97_RS14810	COG3954	Phosphoribulokinase
E2H97_RS14845	COG1012	belongs to the aldehyde dehydrogenase family
E2H97_RS14855	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E2H97_RS14885	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
E2H97_RS14890	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
E2H97_RS14895	COG0195	Participates in both transcription termination and antitermination
E2H97_RS14915	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E2H97_RS14920	COG0149	triose-phosphate isomerase activity
E2H97_RS14935	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E2H97_RS14940	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E2H97_RS14945	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
E2H97_RS14950	COG1534	Rna-binding protein
E2H97_RS14955	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E2H97_RS14960	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E2H97_RS14970	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E2H97_RS14975	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E2H97_RS14985	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E2H97_RS14990	COG0505	Belongs to the CarA family
E2H97_RS14995	COG0039	L-malate dehydrogenase activity
E2H97_RS15000	COG1438	arginine binding
E2H97_RS15005	COG2985	domain, Protein
E2H97_RS15010	COG2837	iron assimilation
E2H97_RS15015	COG3590	peptidase
E2H97_RS15030	COG5433	transposase activity
E2H97_RS15045	COG1785	Belongs to the alkaline phosphatase family
E2H97_RS15050	COG1785	Belongs to the alkaline phosphatase family
E2H97_RS15065	COG0625	glutathione transferase activity
E2H97_RS15070	COG1187	pseudouridine synthase activity
E2H97_RS15085	COG1595	DNA-templated transcription, initiation
E2H97_RS15090	COG2423	ornithine cyclodeaminase activity
E2H97_RS15105	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E2H97_RS15110	COG0069	glutamate synthase activity
E2H97_RS15120	COG1666	GTP binding
E2H97_RS15130	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E2H97_RS15135	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
E2H97_RS15145	COG2890	protein-(glutamine-N5) methyltransferase activity
E2H97_RS15165	COG2877	3-deoxy-8-phosphooctulonate synthase activity
E2H97_RS15170	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
E2H97_RS15175	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
E2H97_RS15180	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E2H97_RS15190	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E2H97_RS15205	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
E2H97_RS15210	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
E2H97_RS15215	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
E2H97_RS15230	COG3148	PFAM DTW domain containing protein
E2H97_RS15235	COG3091	SprT-like family
E2H97_RS15240	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
E2H97_RS15250	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
E2H97_RS15275	COG3848	Pyruvate phosphate dikinase
E2H97_RS15275	COG0574	Belongs to the PEP-utilizing enzyme family
E2H97_RS15295	COG0741	lytic transglycosylase activity
E2H97_RS15330	COG1595	DNA-templated transcription, initiation
E2H97_RS15350	COG2813	Specifically methylates the guanine in position
E2H97_RS15365	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E2H97_RS15370	COG1566	PFAM secretion protein HlyD family protein
E2H97_RS15380	COG0513	Belongs to the DEAD box helicase family
E2H97_RS15395	COG1566	PFAM secretion protein HlyD family protein
E2H97_RS15410	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
E2H97_RS15420	COG4974	Belongs to the 'phage' integrase family
E2H97_RS15425	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E2H97_RS15465	COG0439	Biotin carboxylase
E2H97_RS15470	COG0583	DNA-binding transcription factor activity
E2H97_RS15590	COG2197	response regulator
E2H97_RS15600	COG0840	transmembrane signaling receptor activity
E2H97_RS15605	COG1858	cytochrome C peroxidase
E2H97_RS15610	COG3321	synthase
E2H97_RS15610	COG1028	Short-chain dehydrogenase reductase Sdr
E2H97_RS15610	COG0604	alcohol dehydrogenase
E2H97_RS15620	COG2017	converts alpha-aldose to the beta-anomer
E2H97_RS15625	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E2H97_RS15630	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E2H97_RS15640	COG1404	Belongs to the peptidase S8 family
E2H97_RS15655	COG0454	-acetyltransferase
E2H97_RS15685	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
E2H97_RS15690	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E2H97_RS15695	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E2H97_RS15705	COG3074	FtsZ-dependent cytokinesis
E2H97_RS15710	COG1757	Na H antiporter
E2H97_RS15720	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
E2H97_RS15730	COG0671	phosphoesterase, PA-phosphatase related
E2H97_RS15740	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E2H97_RS15745	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
E2H97_RS15760	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
E2H97_RS15785	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E2H97_RS15795	COG1392	Phosphate transport regulator
E2H97_RS15800	COG0306	phosphate transporter
E2H97_RS15815	COG0506	proline dehydrogenase activity
E2H97_RS15815	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E2H97_RS15815	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E2H97_RS15830	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E2H97_RS15850	COG0545	Peptidyl-prolyl cis-trans isomerase
E2H97_RS15945	COG5290	Psort location Cytoplasmic, score
E2H97_RS16000	COG3150	esterase
E2H97_RS16010	COG3151	Protein conserved in bacteria
E2H97_RS16015	COG0494	nUDIX hydrolase
E2H97_RS16020	COG1538	Outer membrane efflux protein
E2H97_RS16040	COG2211	Major facilitator Superfamily
E2H97_RS16070	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
E2H97_RS16075	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
E2H97_RS16085	COG3227	Zinc metalloprotease (Elastase)
E2H97_RS16090	COG3227	Zinc metalloprotease (Elastase)
E2H97_RS16115	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
E2H97_RS16145	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
E2H97_RS16150	COG0210	DNA helicase
E2H97_RS16160	COG0330	HflC and HflK could
E2H97_RS16165	COG0330	HflC and HflK could
E2H97_RS16195	COG2153	protein acetylation
E2H97_RS16205	COG0534	Mate efflux family protein
E2H97_RS16275	COG0739	heme binding
E2H97_RS16285	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
E2H97_RS16290	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E2H97_RS16295	COG0849	cell division
E2H97_RS16300	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
E2H97_RS16305	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E2H97_RS16310	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E2H97_RS16315	COG0772	Belongs to the SEDS family
E2H97_RS16320	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E2H97_RS16325	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E2H97_RS16330	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E2H97_RS16335	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E2H97_RS16340	COG0768	penicillin binding
E2H97_RS16345	COG3116	cell division
E2H97_RS16350	COG0275	rRNA processing
E2H97_RS16355	COG2001	Belongs to the MraZ family
E2H97_RS16370	COG0514	ATP-dependent DNA helicase (RecQ)
E2H97_RS16375	COG2962	Rard protein
E2H97_RS16390	COG0227	Belongs to the bacterial ribosomal protein bL28 family
E2H97_RS16395	COG2003	Belongs to the UPF0758 family
E2H97_RS16400	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E2H97_RS16410	COG1309	transcriptional regulator
E2H97_RS16435	COG3119	arylsulfatase activity
E2H97_RS16445	COG2186	Transcriptional regulator
E2H97_RS16450	COG1028	Short-chain dehydrogenase reductase Sdr
E2H97_RS16455	COG0681	Belongs to the peptidase S26 family
E2H97_RS16460	COG3119	arylsulfatase activity
E2H97_RS16465	COG3119	arylsulfatase activity
E2H97_RS16470	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E2H97_RS16475	COG1757	Na H antiporter
E2H97_RS16485	COG3119	arylsulfatase activity
E2H97_RS16495	COG0302	gtp cyclohydrolase
E2H97_RS16505	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
E2H97_RS16515	COG1561	YicC-like family, N-terminal region
E2H97_RS16530	COG0494	nUDIX hydrolase
E2H97_RS16615	COG0456	acetyltransferase
E2H97_RS16620	COG0242	peptide deformylase activity
E2H97_RS16650	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
E2H97_RS16655	COG2948	multi-organism process
E2H97_RS16660	COG3504	Conjugal transfer protein
E2H97_RS16665	COG3736	Type IV secretory pathway, component VirB8
E2H97_RS16685	COG3451	type IV secretory pathway VirB4
E2H97_RS16745	COG2072	flavoprotein involved in K transport
E2H97_RS16750	COG0300	oxidoreductase activity
E2H97_RS16750	COG0318	PFAM AMP-dependent synthetase and ligase
E2H97_RS16750	COG1028	Short-chain dehydrogenase reductase Sdr
E2H97_RS16750	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E2H97_RS16750	COG3321	synthase
E2H97_RS16755	COG0318	PFAM AMP-dependent synthetase and ligase
E2H97_RS16805	COG0318	PFAM AMP-dependent synthetase and ligase
E2H97_RS16810	COG2814	Major facilitator Superfamily
E2H97_RS16825	COG1228	amidohydrolase
E2H97_RS16840	COG2986	histidine ammonia-lyase
E2H97_RS16860	COG1011	Hydrolase
E2H97_RS16880	COG1022	Amp-dependent synthetase and ligase
E2H97_RS16890	COG4555	ABC transporter
E2H97_RS16895	COG1668	transmembrane transport
E2H97_RS16935	COG0194	GDP metabolic process
E2H97_RS16940	COG1758	RNA polymerase activity
E2H97_RS16945	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E2H97_RS16955	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E2H97_RS16980	COG1129	ABC transporter
E2H97_RS16980	COG0842	Transport permease protein
E2H97_RS16985	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E2H97_RS16995	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
E2H97_RS17000	COG1487	ribonuclease activity
E2H97_RS17010	COG2081	HI0933 family
E2H97_RS17015	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
E2H97_RS17025	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E2H97_RS17035	COG4942	peptidase
E2H97_RS17040	COG0793	Belongs to the peptidase S41A family
E2H97_RS17045	COG2861	carbohydrate metabolic process
E2H97_RS17100	COG3451	type IV secretory pathway VirB4
E2H97_RS17120	COG3736	Type IV secretory pathway, component VirB8
E2H97_RS17125	COG3504	Conjugal transfer protein
E2H97_RS17130	COG2948	multi-organism process
E2H97_RS17135	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
E2H97_RS17440	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
E2H97_RS17445	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
E2H97_RS17450	COG3590	peptidase
E2H97_RS17465	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E2H97_RS17470	COG1049	propionate catabolic process, 2-methylcitrate cycle
E2H97_RS17475	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
E2H97_RS17485	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
E2H97_RS17495	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E2H97_RS17500	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E2H97_RS17510	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E2H97_RS17515	COG0508	dehydrogenase complex catalyzes the overall conversion of
E2H97_RS17520	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
E2H97_RS17525	COG2186	Transcriptional regulator
E2H97_RS17540	COG3023	N-Acetylmuramoyl-L-alanine amidase
E2H97_RS17570	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E2H97_RS17580	COG1459	type II secretion system
E2H97_RS17590	COG0237	dephospho-CoA kinase activity
E2H97_RS17600	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
E2H97_RS17605	COG0494	nUDIX hydrolase
E2H97_RS17610	COG0776	regulation of translation
E2H97_RS17640	COG4235	cytochrome complex assembly
E2H97_RS17640	COG3088	subunit of a heme lyase
E2H97_RS17655	COG4235	cytochrome complex assembly
E2H97_RS17655	COG3088	subunit of a heme lyase
E2H97_RS17665	COG4133	protoheme IX ABC transporter activity
E2H97_RS17670	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E2H97_RS17675	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E2H97_RS17685	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
E2H97_RS17700	COG0203	ribosomal protein L17
E2H97_RS17705	COG0202	RNA polymerase activity
E2H97_RS17710	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
E2H97_RS17715	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
E2H97_RS17720	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E2H97_RS17725	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E2H97_RS17730	COG0201	protein transport
E2H97_RS17735	COG0200	Binds to the 23S rRNA
E2H97_RS17740	COG1841	ribosomal large subunit assembly
E2H97_RS17745	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E2H97_RS17755	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
E2H97_RS17760	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E2H97_RS17765	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
E2H97_RS17770	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
E2H97_RS17775	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
E2H97_RS17780	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
E2H97_RS17790	COG0255	Belongs to the universal ribosomal protein uL29 family
E2H97_RS17795	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
E2H97_RS17800	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
E2H97_RS17805	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
E2H97_RS17810	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
E2H97_RS17815	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
E2H97_RS17820	COG0089	rRNA binding
E2H97_RS17830	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
E2H97_RS17835	COG0051	transcription antitermination factor activity, RNA binding
E2H97_RS17850	COG0840	transmembrane signaling receptor activity
E2H97_RS17865	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
E2H97_RS17875	COG2267	carboxylic ester hydrolase activity
E2H97_RS17880	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
E2H97_RS17895	COG0612	Peptidase, M16
E2H97_RS17900	COG1473	amidohydrolase
E2H97_RS17930	COG2827	Endonuclease containing a URI domain
E2H97_RS17940	COG1528	Iron-storage protein
E2H97_RS17945	COG0303	'Molybdopterin
E2H97_RS17950	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E2H97_RS17955	COG2095	MarC family integral membrane protein
E2H97_RS17980	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
E2H97_RS17985	COG0521	Mo-molybdopterin cofactor biosynthetic process
E2H97_RS17990	COG0315	cyclic pyranopterin monophosphate synthase activity
E2H97_RS17995	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
E2H97_RS18000	COG0314	molybdopterin synthase activity
E2H97_RS18015	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
E2H97_RS18025	COG0745	RESPONSE REGULATOR receiver
E2H97_RS18035	COG0564	pseudouridine synthase activity
E2H97_RS18065	COG1573	uracil-dna glycosylase
E2H97_RS18070	COG2814	Major facilitator Superfamily
E2H97_RS18090	COG1979	alcohol dehydrogenase
E2H97_RS18130	COG0531	amino acid
E2H97_RS18135	COG1522	sequence-specific DNA binding
E2H97_RS18145	COG2177	Part of the ABC transporter FtsEX involved in
E2H97_RS18150	COG2884	Cell division ATP-binding protein ftsE
E2H97_RS18155	COG0552	protein localization to endoplasmic reticulum
E2H97_RS18160	COG0742	ribosomal rna small subunit methyltransferase
E2H97_RS18170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E2H97_RS18175	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E2H97_RS18185	COG2937	Belongs to the GPAT DAPAT family
E2H97_RS18205	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E2H97_RS18220	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E2H97_RS18225	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
E2H97_RS18250	COG1612	heme a metabolic process
E2H97_RS18260	COG1999	signal sequence binding
E2H97_RS18265	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
E2H97_RS18270	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E2H97_RS18295	COG0354	folic acid binding
E2H97_RS18330	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E2H97_RS18380	COG0814	amino acid
E2H97_RS18395	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E2H97_RS18410	COG0583	DNA-binding transcription factor activity
E2H97_RS18430	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E2H97_RS18450	COG0784	Response regulator, receiver
E2H97_RS18450	COG2198	Histidine kinase
E2H97_RS18450	COG2205	protein histidine kinase activity
E2H97_RS18505	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E2H97_RS18515	COG0583	DNA-binding transcription factor activity
E2H97_RS18520	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
E2H97_RS18560	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E2H97_RS18565	COG1349	DNA-binding transcription factor activity
E2H97_RS18575	COG0577	efflux transmembrane transporter activity
E2H97_RS18580	COG0577	efflux transmembrane transporter activity
E2H97_RS18580	COG1136	(ABC) transporter
E2H97_RS18610	COG3328	transposase activity
E2H97_RS18615	COG0318	PFAM AMP-dependent synthetase and ligase
E2H97_RS18620	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
E2H97_RS18650	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
E2H97_RS18660	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
E2H97_RS18670	COG0356	it plays a direct role in the translocation of protons across the membrane
E2H97_RS18675	COG3312	ion transport
E2H97_RS18680	COG1475	DNA binding
E2H97_RS18685	COG1192	Involved in chromosome partitioning
E2H97_RS18690	COG0357	Ribosomal RNA small subunit methyltransferase G
E2H97_RS18695	COG0445	tRNA wobble uridine modification
E2H97_RS18700	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
E2H97_RS18720	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
E2H97_RS18725	COG0706	membrane insertase activity
E2H97_RS18730	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
E2H97_RS18735	COG0594	ribonuclease P activity