locus-tag	class	description
NW74_RS00010	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NW74_RS00015	COG1114	Component of the transport system for branched-chain amino acids
NW74_RS00060	COG0301	tRNA thio-modification
NW74_RS00065	COG1104	cysteine desulfurase activity
NW74_RS00080	COG1404	Belongs to the peptidase S8 family
NW74_RS00080	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
NW74_RS00085	COG1132	(ABC) transporter
NW74_RS00090	COG1132	(ABC) transporter
NW74_RS00090	COG2375	cellular response to nickel ion
NW74_RS00120	COG4555	ABC transporter
NW74_RS00130	COG1191	sigma factor activity
NW74_RS00145	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NW74_RS00150	COG0187	DNA topoisomerase II activity
NW74_RS00155	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
NW74_RS00165	COG0592	DNA-directed DNA polymerase activity
NW74_RS00170	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
NW74_RS00190	COG0594	ribonuclease P activity
NW74_RS00195	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
NW74_RS00200	COG0706	membrane insertase activity
NW74_RS00205	COG1847	R3H domain protein
NW74_RS00210	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
NW74_RS00220	COG1304	FMN binding
NW74_RS00225	COG1316	TRANSCRIPTIONal
NW74_RS00235	COG0577	efflux transmembrane transporter activity
NW74_RS00240	COG1136	(ABC) transporter
NW74_RS00255	COG2205	protein histidine kinase activity
NW74_RS00275	COG0280	phosphate acetyltransferase
NW74_RS00280	COG1597	lipid kinase activity
NW74_RS00290	COG1104	cysteine desulfurase activity
NW74_RS00295	COG1475	DNA binding
NW74_RS00300	COG1192	Involved in chromosome partitioning
NW74_RS00305	COG0791	NLP P60 protein
NW74_RS00315	COG0357	Ribosomal RNA small subunit methyltransferase G
NW74_RS00320	COG0445	tRNA wobble uridine modification
NW74_RS00330	COG0698	ribose 5-phosphate isomerase
NW74_RS00335	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
NW74_RS00380	COG0488	(ABC) transporter
NW74_RS00410	COG3859	Proton-coupled thiamine transporter YuaJ
NW74_RS00415	COG0584	glycerophosphoryl diester phosphodiesterase
NW74_RS00420	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
NW74_RS00425	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
NW74_RS00440	COG1027	Aspartate ammonia-lyase
NW74_RS00445	COG1755	Isoprenylcysteine carboxyl methyltransferase
NW74_RS00460	COG1164	Oligoendopeptidase f
NW74_RS00465	COG1393	Belongs to the ArsC family
NW74_RS00470	COG1695	Transcriptional regulator
NW74_RS00495	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
NW74_RS00500	COG4604	ABC transporter, ATP-binding protein
NW74_RS00510	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
NW74_RS00555	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NW74_RS00560	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
NW74_RS00575	COG1104	cysteine desulfurase activity
NW74_RS00610	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
NW74_RS00615	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
NW74_RS00620	COG0037	tRNA processing
NW74_RS00630	COG1695	Transcriptional regulator
NW74_RS00640	COG1362	aminopeptidase activity
NW74_RS00645	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
NW74_RS00650	COG1064	alcohol dehydrogenase
NW74_RS00665	COG0745	RESPONSE REGULATOR receiver
NW74_RS00670	COG5002	protein histidine kinase activity
NW74_RS00685	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NW74_RS00710	COG4232	protein-disulfide reductase activity
NW74_RS00735	COG2378	regulation of single-species biofilm formation
NW74_RS00775	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
NW74_RS00820	COG1131	(ABC) transporter
NW74_RS00825	COG1309	transcriptional regulator
NW74_RS00835	COG0577	efflux transmembrane transporter activity
NW74_RS00840	COG1136	(ABC) transporter
NW74_RS00855	COG5002	protein histidine kinase activity
NW74_RS00865	COG0534	Mate efflux family protein
NW74_RS00900	COG2217	Heavy metal translocating P-type atpase
NW74_RS00915	COG0823	Involved in the tonB-independent uptake of proteins
NW74_RS00915	COG4946	Tricorn protease homolog
NW74_RS00915	COG1506	peptidase
NW74_RS00920	COG0456	acetyltransferase
NW74_RS00935	COG2801	Transposase and inactivated derivatives
NW74_RS00980	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
NW74_RS00985	COG0359	binds to the 23S rRNA
NW74_RS00990	COG0305	Participates in initiation and elongation during chromosome replication
NW74_RS01010	COG0628	permease
NW74_RS01015	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
NW74_RS01020	COG1686	Belongs to the peptidase S11 family
NW74_RS01040	COG1187	pseudouridine synthase activity
NW74_RS01080	COG0488	(ABC) transporter
NW74_RS01085	COG1716	ATPase activity
NW74_RS01095	COG0768	penicillin binding
NW74_RS01105	COG1164	Oligoendopeptidase f
NW74_RS01120	COG1285	pathogenesis
NW74_RS01125	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
NW74_RS01130	COG0572	uridine kinase
NW74_RS01140	COG0746	molybdenum cofactor guanylyltransferase activity
NW74_RS01145	COG1418	mRNA catabolic process
NW74_RS01170	COG1970	mechanosensitive ion channel activity
NW74_RS01185	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NW74_RS01200	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
NW74_RS01220	COG1328	CTP reductase activity
NW74_RS01225	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
NW74_RS01235	COG0802	atpase or kinase
NW74_RS01240	COG1214	PFAM Peptidase M22, glycoprotease
NW74_RS01250	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
NW74_RS01335	COG1917	Cupin 2, conserved barrel domain protein
NW74_RS01335	COG2207	Transcriptional regulator
NW74_RS01340	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
NW74_RS01360	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
NW74_RS01365	COG0049	tRNA binding
NW74_RS01370	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NW74_RS01375	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
NW74_RS01385	COG0588	phosphoglycerate mutase activity
NW74_RS01390	COG1176	ABC-type spermidine putrescine transport system, permease component I
NW74_RS01395	COG1177	transmembrane transport
NW74_RS01400	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
NW74_RS01405	COG0531	amino acid
NW74_RS01410	COG1362	aminopeptidase activity
NW74_RS01420	COG1979	alcohol dehydrogenase
NW74_RS01435	COG1131	(ABC) transporter
NW74_RS01445	COG1609	Transcriptional regulator
NW74_RS01450	COG1132	(ABC) transporter
NW74_RS01455	COG1132	(ABC) transporter
NW74_RS01465	COG0254	rRNA binding
NW74_RS01490	COG0534	Mate efflux family protein
NW74_RS01500	COG0537	adenosine 5'-monophosphoramidase activity
NW74_RS01505	COG0828	Belongs to the bacterial ribosomal protein bS21 family
NW74_RS01510	COG1522	sequence-specific DNA binding
NW74_RS01510	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NW74_RS01520	COG1132	(ABC) transporter
NW74_RS01540	COG0574	Belongs to the PEP-utilizing enzyme family
NW74_RS01540	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NW74_RS01545	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
NW74_RS01580	COG1131	(ABC) transporter
NW74_RS01590	COG0386	Belongs to the glutathione peroxidase family
NW74_RS01595	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
NW74_RS01600	COG2235	arginine
NW74_RS01610	COG0653	protein targeting
NW74_RS01615	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NW74_RS01630	COG0653	protein targeting
NW74_RS01665	COG1114	Component of the transport system for branched-chain amino acids
NW74_RS01670	COG2873	o-acetylhomoserine
NW74_RS01685	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NW74_RS01690	COG1012	belongs to the aldehyde dehydrogenase family
NW74_RS01715	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
NW74_RS01720	COG3870	Protein conserved in bacteria
NW74_RS01725	COG3870	Protein conserved in bacteria
NW74_RS01745	COG0116	Belongs to the methyltransferase superfamily
NW74_RS01765	COG0303	'Molybdopterin
NW74_RS01800	COG0367	asparagine synthase
NW74_RS01820	COG0442	prolyl-tRNA aminoacylation
NW74_RS01830	COG1132	(ABC) transporter
NW74_RS01840	COG1328	CTP reductase activity
NW74_RS01840	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
NW74_RS01845	COG0602	queuosine metabolic process
NW74_RS01850	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
NW74_RS01855	COG1132	(ABC) transporter
NW74_RS01865	COG1132	(ABC) transporter
NW74_RS01870	COG3022	response to hydroperoxide
NW74_RS01880	COG1266	CAAX protease self-immunity
NW74_RS01905	COG1473	amidohydrolase
NW74_RS01935	COG2183	response to ionizing radiation
NW74_RS01950	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
NW74_RS01955	COG0291	Belongs to the bacterial ribosomal protein bL35 family
NW74_RS01960	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
NW74_RS01965	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NW74_RS01970	COG0569	domain protein
NW74_RS01975	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NW74_RS01980	COG3579	cysteine-type endopeptidase activity
NW74_RS01990	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NW74_RS02005	COG4545	Glutaredoxin-related protein
NW74_RS02010	COG2195	Cleaves the N-terminal amino acid of tripeptides
NW74_RS02030	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NW74_RS02035	COG1307	EDD domain protein, DegV family
NW74_RS02050	COG0261	This protein binds to 23S rRNA in the presence of protein L20
NW74_RS02060	COG0211	Belongs to the bacterial ribosomal protein bL27 family
NW74_RS02065	COG1160	GTP binding
NW74_RS02070	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
NW74_RS02085	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
NW74_RS02090	COG0333	Belongs to the bacterial ribosomal protein bL32 family
NW74_RS02105	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NW74_RS02110	COG1120	ATPase activity
NW74_RS02115	COG2264	protein methyltransferase activity
NW74_RS02125	COG0012	GTP binding
NW74_RS02130	COG1051	belongs to the nudix hydrolase family
NW74_RS02150	COG1132	(ABC) transporter
NW74_RS02155	COG1132	(ABC) transporter
NW74_RS02165	COG0196	riboflavin kinase activity
NW74_RS02170	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NW74_RS02180	COG4475	Protein of unknown function (DUF436)
NW74_RS02190	COG0517	IMP dehydrogenase activity
NW74_RS02190	COG0516	GMP reductase activity
NW74_RS02195	COG0509	glycine decarboxylation via glycine cleavage system
NW74_RS02200	COG0697	spore germination
NW74_RS02205	COG3583	domain protein
NW74_RS02205	COG3584	3D domain protein
NW74_RS02210	COG2270	Major facilitator Superfamily
NW74_RS02215	COG3475	LICD family
NW74_RS02220	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
NW74_RS02225	COG0217	transcriptional regulatory protein
NW74_RS02235	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
NW74_RS02240	COG2001	Belongs to the MraZ family
NW74_RS02245	COG0275	rRNA processing
NW74_RS02255	COG0768	penicillin binding
NW74_RS02260	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NW74_RS02270	COG0772	Belongs to the SEDS family
NW74_RS02275	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NW74_RS02285	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
NW74_RS02290	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
NW74_RS02315	COG2890	protein-(glutamine-N5) methyltransferase activity
NW74_RS02330	COG0681	Belongs to the peptidase S26 family
NW74_RS02335	COG0481	GTPase activity
NW74_RS02350	COG0546	phosphoglycolate phosphatase activity
NW74_RS02360	COG0573	inorganic phosphate transmembrane transporter activity
NW74_RS02370	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NW74_RS02375	COG1132	(ABC) transporter
NW74_RS02380	COG1132	(ABC) transporter
NW74_RS02385	COG1132	(ABC) transporter
NW74_RS02390	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
NW74_RS02395	COG1074	ATP-dependent DNA helicase activity
NW74_RS02430	COG1269	ATP hydrolysis coupled proton transport
NW74_RS02460	COG1394	ATPase activity, coupled to movement of substances
NW74_RS02465	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NW74_RS02565	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
NW74_RS02590	COG4496	protein, YerC YecD
NW74_RS02595	COG0006	proline dipeptidase activity
NW74_RS02600	COG0322	excinuclease ABC activity
NW74_RS02605	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
NW74_RS02610	COG0812	UDP-N-acetylmuramate dehydrogenase activity
NW74_RS02615	COG1660	Displays ATPase and GTPase activities
NW74_RS02620	COG0391	Required for morphogenesis under gluconeogenic growth conditions
NW74_RS02625	COG0484	heat shock protein binding
NW74_RS02630	COG2264	protein methyltransferase activity
NW74_RS02640	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NW74_RS02645	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NW74_RS02645	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NW74_RS02650	COG0084	hydrolase, TatD family'
NW74_RS02660	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
NW74_RS02675	COG0671	phosphoesterase, PA-phosphatase related
NW74_RS02685	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
NW74_RS02695	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
NW74_RS02700	COG1799	cell septum assembly
NW74_RS02710	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
NW74_RS02715	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
NW74_RS02720	COG0564	pseudouridine synthase activity
NW74_RS02735	COG1278	Cold shock
NW74_RS02740	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
NW74_RS02740	COG0456	acetyltransferase
NW74_RS02750	COG0534	Mate efflux family protein
NW74_RS02755	COG0495	leucyl-tRNA aminoacylation
NW74_RS02785	COG0561	phosphatase activity
NW74_RS02800	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
NW74_RS02805	COG0443	Heat shock 70 kDa protein
NW74_RS02815	COG0544	peptidyl-prolyl cis-trans isomerase activity
NW74_RS02820	COG0740	serine-type endopeptidase activity
NW74_RS02825	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
NW74_RS02830	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
NW74_RS02835	COG0218	Necessary for normal cell division and for the maintenance of normal septation
NW74_RS02840	COG1132	(ABC) transporter
NW74_RS02845	COG4555	ABC transporter
NW74_RS02860	COG3579	cysteine-type endopeptidase activity
NW74_RS02870	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
NW74_RS02875	COG0726	polysaccharide deacetylase
NW74_RS02890	COG0051	transcription antitermination factor activity, RNA binding
NW74_RS02895	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
NW74_RS02900	COG0088	Forms part of the polypeptide exit tunnel
NW74_RS02905	COG0089	rRNA binding
NW74_RS02910	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
NW74_RS02915	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
NW74_RS02920	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
NW74_RS02925	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
NW74_RS02930	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
NW74_RS02935	COG0255	Belongs to the universal ribosomal protein uL29 family
NW74_RS02940	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
NW74_RS02945	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
NW74_RS02950	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
NW74_RS02955	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
NW74_RS02960	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
NW74_RS02965	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
NW74_RS02970	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
NW74_RS02975	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
NW74_RS02980	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
NW74_RS02985	COG1841	ribosomal large subunit assembly
NW74_RS02990	COG0200	Binds to the 23S rRNA
NW74_RS02995	COG0201	protein transport
NW74_RS03000	COG0563	adenylate kinase activity
NW74_RS03010	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
NW74_RS03015	COG0257	Belongs to the bacterial ribosomal protein bL36 family
NW74_RS03020	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
NW74_RS03025	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
NW74_RS03030	COG0202	RNA polymerase activity
NW74_RS03035	COG0203	ribosomal protein L17
NW74_RS03045	COG0628	permease
NW74_RS03050	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
NW74_RS03055	COG4472	Bacterial protein of unknown function (DUF965)
NW74_RS03065	COG3906	Belongs to the UPF0473 family
NW74_RS03075	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
NW74_RS03085	COG4122	O-methyltransferase activity
NW74_RS03090	COG0826	peptidase U32
NW74_RS03100	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
NW74_RS03105	COG1185	polyribonucleotide nucleotidyltransferase activity
NW74_RS03115	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NW74_RS03125	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NW74_RS03125	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NW74_RS03140	COG4463	regulation of RNA biosynthetic process
NW74_RS03155	COG0542	response to heat
NW74_RS03165	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NW74_RS03170	COG2759	Belongs to the formate--tetrahydrofolate ligase family
NW74_RS03175	COG3404	Formiminotransferase-cyclodeaminase
NW74_RS03180	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
NW74_RS03190	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
NW74_RS03195	COG1307	EDD domain protein, DegV family
NW74_RS03205	COG1346	cytolysis
NW74_RS03225	COG0728	peptidoglycan biosynthetic process
NW74_RS03235	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
NW74_RS03240	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
NW74_RS03250	COG3976	FMN-binding domain protein
NW74_RS03250	COG1053	succinate dehydrogenase
NW74_RS03255	COG3976	FMN-binding domain protein
NW74_RS03255	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
NW74_RS03260	COG0672	)-iron permease
NW74_RS03275	COG0577	efflux transmembrane transporter activity
NW74_RS03280	COG1136	(ABC) transporter
NW74_RS03280	COG0577	efflux transmembrane transporter activity
NW74_RS03285	COG1136	(ABC) transporter
NW74_RS03310	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NW74_RS03330	COG3383	formate dehydrogenase (NAD+) activity
NW74_RS03335	COG0745	RESPONSE REGULATOR receiver
NW74_RS03340	COG5002	protein histidine kinase activity
NW74_RS03350	COG0583	DNA-binding transcription factor activity
NW74_RS03360	COG0584	glycerophosphoryl diester phosphodiesterase
NW74_RS03375	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
NW74_RS03380	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
NW74_RS03385	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NW74_RS03395	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
NW74_RS03400	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
NW74_RS03405	COG0138	bifunctional purine biosynthesis protein purh
NW74_RS03410	COG0151	Belongs to the GarS family
NW74_RS03415	COG0360	Binds together with S18 to 16S ribosomal RNA
NW74_RS03420	COG0629	single-stranded DNA binding
NW74_RS03425	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
NW74_RS03450	COG3620	sequence-specific DNA binding
NW74_RS03455	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
NW74_RS03460	COG1739	Uncharacterized protein family UPF0029
NW74_RS03465	COG3845	ABC transporter
NW74_RS03470	COG4603	Belongs to the binding-protein-dependent transport system permease family
NW74_RS03475	COG1079	Belongs to the binding-protein-dependent transport system permease family
NW74_RS03485	COG2390	Transcriptional regulator
NW74_RS03495	COG0126	phosphoglycerate kinase activity
NW74_RS03500	COG0149	triose-phosphate isomerase activity
NW74_RS03505	COG0148	phosphopyruvate hydratase activity
NW74_RS03555	COG1862	Preprotein translocase
NW74_RS03565	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NW74_RS03575	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NW74_RS03580	COG0579	oxidoreductase
NW74_RS03585	COG0446	pyridine nucleotide-disulphide oxidoreductase
NW74_RS03595	COG0779	Required for maturation of 30S ribosomal subunits
NW74_RS03600	COG0195	Participates in both transcription termination and antitermination
NW74_RS03610	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
NW74_RS03610	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
NW74_RS03615	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
NW74_RS03630	COG0424	maF-like protein
NW74_RS03640	COG2239	Acts as a magnesium transporter
NW74_RS03645	COG2239	Acts as a magnesium transporter
NW74_RS03650	COG0742	ribosomal rna small subunit methyltransferase
NW74_RS03655	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
NW74_RS03665	COG1702	phosphate starvation-inducible protein PhoH
NW74_RS03670	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
NW74_RS03680	COG0295	cytidine deaminase activity
NW74_RS03685	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
NW74_RS03695	COG0358	DNA primase activity
NW74_RS03700	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NW74_RS03715	COG0557	exoribonuclease II activity
NW74_RS03725	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NW74_RS03730	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
NW74_RS03735	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
NW74_RS03745	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
NW74_RS03755	COG2720	vancomycin resistance protein
NW74_RS03760	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
NW74_RS03765	COG4974	Belongs to the 'phage' integrase family
NW74_RS03775	COG0018	arginyl-trna synthetase
NW74_RS03780	COG1193	negative regulation of DNA recombination
NW74_RS03790	COG0072	phenylalanine-tRNA ligase activity
NW74_RS03790	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NW74_RS03795	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
NW74_RS03800	COG0745	RESPONSE REGULATOR receiver
NW74_RS03815	COG0709	Synthesizes selenophosphate from selenide and ATP
NW74_RS03820	COG1555	photosystem II stabilization
NW74_RS03820	COG1596	polysaccharide export
NW74_RS03825	COG0017	Asparaginyl-tRNA synthetase
NW74_RS03835	COG0335	large ribosomal subunit rRNA binding
NW74_RS03840	COG0336	Belongs to the RNA methyltransferase TrmD family
NW74_RS03845	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
NW74_RS03855	COG0228	four-way junction DNA binding
NW74_RS03860	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
NW74_RS03870	COG0552	protein localization to endoplasmic reticulum
NW74_RS03890	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NW74_RS03900	COG1213	nucleotidyl transferase
NW74_RS03910	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
NW74_RS03915	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NW74_RS03925	COG0756	dUTP diphosphatase activity
NW74_RS03955	COG2309	aminopeptidase activity
NW74_RS03965	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NW74_RS03980	COG0745	RESPONSE REGULATOR receiver
NW74_RS04075	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NW74_RS04075	COG0519	Catalyzes the synthesis of GMP from XMP
NW74_RS04080	COG1744	ABC transporter substrate-binding protein PnrA-like
NW74_RS04085	COG0768	penicillin binding
NW74_RS04100	COG1077	Cell shape determining protein MreB Mrl
NW74_RS04105	COG2003	Belongs to the UPF0758 family
NW74_RS04145	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
NW74_RS04165	COG5505	Protein of unknown function (DUF819)
NW74_RS04185	COG0525	valine-tRNA ligase activity
NW74_RS04190	COG0450	alkyl hydroperoxide reductase
NW74_RS04200	COG0484	heat shock protein binding
NW74_RS04205	COG0425	Belongs to the sulfur carrier protein TusA family
NW74_RS04220	COG0297	glycogen (starch) synthase activity
NW74_RS04220	COG0438	transferase activity, transferring glycosyl groups
NW74_RS04225	COG3475	LICD family
NW74_RS04230	COG1063	alcohol dehydrogenase
NW74_RS04235	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
NW74_RS04240	COG1215	transferase activity, transferring glycosyl groups
NW74_RS04245	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NW74_RS04255	COG0205	6-phosphofructokinase activity
NW74_RS04270	COG1253	flavin adenine dinucleotide binding
NW74_RS04280	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
NW74_RS04290	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NW74_RS04295	COG2996	Protein conserved in bacteria
NW74_RS04310	COG4864	UPF0365 protein
NW74_RS04320	COG0772	Belongs to the SEDS family
NW74_RS04330	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
NW74_RS04330	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
NW74_RS04340	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
NW74_RS04345	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
NW74_RS04350	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
NW74_RS04355	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
NW74_RS04365	COG0438	transferase activity, transferring glycosyl groups
NW74_RS04370	COG0268	Binds directly to 16S ribosomal RNA
NW74_RS04390	COG4589	Belongs to the CDS family
NW74_RS04400	COG0233	cytoplasmic translational termination
NW74_RS04405	COG0528	UMP kinase activity
NW74_RS04415	COG1132	(ABC) transporter
NW74_RS04420	COG3271	cysteine-type peptidase activity
NW74_RS04420	COG2274	protein secretion by the type I secretion system
NW74_RS04425	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
NW74_RS04445	COG0539	negative regulation of cytoplasmic translation
NW74_RS04445	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
NW74_RS04450	COG0204	Acyl-transferase
NW74_RS04455	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
NW74_RS04460	COG2081	HI0933 family
NW74_RS04465	COG0227	Belongs to the bacterial ribosomal protein bL28 family
NW74_RS04475	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NW74_RS04480	COG0210	DNA helicase
NW74_RS04490	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
NW74_RS04495	COG3842	ATPase activity
NW74_RS04510	COG0534	Mate efflux family protein
NW74_RS04515	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
NW74_RS04520	COG0052	Belongs to the universal ribosomal protein uS2 family
NW74_RS04535	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
NW74_RS04540	COG0193	aminoacyl-tRNA hydrolase activity
NW74_RS04550	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
NW74_RS04560	COG1129	ABC transporter
NW74_RS04570	COG1132	(ABC) transporter
NW74_RS04575	COG1132	(ABC) transporter
NW74_RS04580	COG0081	regulation of translation
NW74_RS04585	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
NW74_RS04590	COG0250	Participates in transcription elongation, termination and antitermination
NW74_RS04595	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
NW74_RS04600	COG0267	Belongs to the bacterial ribosomal protein bL33 family
NW74_RS04605	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
NW74_RS04610	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
NW74_RS04615	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
NW74_RS04620	COG0210	DNA helicase
NW74_RS04625	COG3976	FMN-binding domain protein
NW74_RS04625	COG1053	succinate dehydrogenase
NW74_RS04630	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NW74_RS04635	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
NW74_RS04660	COG0488	(ABC) transporter
NW74_RS04670	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
NW74_RS04695	COG3594	Acyltransferase
NW74_RS04715	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NW74_RS04735	COG0459	protein refolding
NW74_RS04740	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
NW74_RS04750	COG0803	Belongs to the bacterial solute-binding protein 9 family
NW74_RS04750	COG3443	Belongs to the bacterial solute-binding protein 9 family
NW74_RS04755	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NW74_RS04760	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NW74_RS04830	COG0535	radical SAM domain protein
NW74_RS04850	COG1131	(ABC) transporter
NW74_RS04855	COG0535	radical SAM domain protein
NW74_RS04885	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NW74_RS04885	COG0551	DNA topoisomerase type I activity
NW74_RS04900	COG3103	Sh3 type 3 domain protein
NW74_RS04900	COG0791	NLP P60 protein
NW74_RS04900	COG1388	LysM domain
NW74_RS04980	COG1132	(ABC) transporter
NW74_RS04985	COG2375	cellular response to nickel ion
NW74_RS04985	COG1132	(ABC) transporter
NW74_RS04990	COG1129	ABC transporter
NW74_RS05075	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
NW74_RS05085	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
NW74_RS05095	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NW74_RS05100	COG0708	Exodeoxyribonuclease III
NW74_RS05105	COG0737	Belongs to the 5'-nucleotidase family
NW74_RS05110	COG3639	organic phosphonate transmembrane transporter activity
NW74_RS05115	COG0765	amino acid transport
NW74_RS05120	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
NW74_RS05130	COG1040	competence protein
NW74_RS05135	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NW74_RS05140	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NW74_RS05145	COG1217	gtp-binding protein TYPA
NW74_RS05155	COG0095	Lipoate-protein ligase
NW74_RS05160	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NW74_RS05165	COG0508	dehydrogenase complex catalyzes the overall conversion of
NW74_RS05170	COG0508	dehydrogenase complex catalyzes the overall conversion of
NW74_RS05170	COG0022	dehydrogenase e1 component
NW74_RS05175	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
NW74_RS05185	COG0252	asparaginase activity
NW74_RS05190	COG0733	neurotransmitter:sodium symporter activity
NW74_RS05195	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
NW74_RS05215	COG2186	Transcriptional regulator
NW74_RS05240	COG1309	transcriptional regulator
NW74_RS05245	COG1477	protein flavinylation
NW74_RS05255	COG2337	Toxic component of a toxin-antitoxin (TA) module
NW74_RS05265	COG0222	ribosome binding
NW74_RS05270	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
NW74_RS05280	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
NW74_RS05295	COG0658	competence protein
NW74_RS05295	COG2333	competence protein COMEC
NW74_RS05310	COG0009	L-threonylcarbamoyladenylate synthase
NW74_RS05325	COG0569	domain protein
NW74_RS05340	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
NW74_RS05345	COG1564	THIamine pyrophosphokinase
NW74_RS05350	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
NW74_RS05365	COG1363	Peptidase, m42
NW74_RS05375	COG1177	transmembrane transport
NW74_RS05380	COG1176	ABC-type spermidine putrescine transport system, permease component I
NW74_RS05385	COG3842	ATPase activity
NW74_RS05390	COG1396	sequence-specific DNA binding
NW74_RS05405	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NW74_RS05410	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
NW74_RS05415	COG0037	tRNA processing
NW74_RS05425	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
NW74_RS05430	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NW74_RS05440	COG1696	Membrane protein involved in D-alanine export
NW74_RS05455	COG0251	oxidation-reduction process
NW74_RS05460	COG0799	negative regulation of ribosome biogenesis
NW74_RS05465	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
NW74_RS05470	COG1534	Rna-binding protein
NW74_RS05475	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
NW74_RS05480	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
NW74_RS05485	COG1162	GTPase activity
NW74_RS05490	COG2815	serine threonine protein kinase
NW74_RS05490	COG0515	serine threonine protein kinase
NW74_RS05495	COG0631	protein serine/threonine phosphatase activity
NW74_RS05500	COG0793	Belongs to the peptidase S41A family
NW74_RS05505	COG1196	nuclear chromosome segregation
NW74_RS05505	COG0739	heme binding
NW74_RS05505	COG0741	lytic transglycosylase activity
NW74_RS05510	COG2177	Part of the ABC transporter FtsEX involved in
NW74_RS05515	COG2884	Cell division ATP-binding protein ftsE
NW74_RS05520	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NW74_RS05525	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NW74_RS05535	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
NW74_RS05550	COG0820	rRNA (adenine-C2-)-methyltransferase activity
NW74_RS05560	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
NW74_RS05565	COG0556	nucleotide-excision repair
NW74_RS05570	COG1136	(ABC) transporter
NW74_RS05580	COG1774	PSP1 C-terminal conserved region
NW74_RS05590	COG2131	deaminase
NW74_RS05610	COG3688	RNA-binding protein containing a PIN domain
NW74_RS05615	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NW74_RS05620	COG0215	cysteine-tRNA ligase activity
NW74_RS05625	COG0584	glycerophosphoryl diester phosphodiesterase
NW74_RS05630	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NW74_RS05640	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
NW74_RS05675	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NW74_RS05685	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
NW74_RS05695	COG0758	DNA mediated transformation
NW74_RS05700	COG0606	chelatase, subunit chli
NW74_RS05705	COG0521	Mo-molybdopterin cofactor biosynthetic process
NW74_RS05710	COG0792	nuclease activity
NW74_RS05715	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
NW74_RS05730	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
NW74_RS05735	COG1518	maintenance of DNA repeat elements
NW74_RS05750	COG2015	COG2015, Alkyl sulfatase and related hydrolases
NW74_RS05780	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
NW74_RS05790	COG1187	pseudouridine synthase activity
NW74_RS05795	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
NW74_RS05810	COG0494	nUDIX hydrolase
NW74_RS05815	COG0497	DNA recombination
NW74_RS05820	COG1438	arginine binding
NW74_RS05825	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
NW74_RS05850	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NW74_RS05860	COG1301	dicarboxylic acid transport
NW74_RS05865	COG2197	response regulator
NW74_RS05875	COG1131	(ABC) transporter
NW74_RS05895	COG0343	queuine tRNA-ribosyltransferase activity
NW74_RS05900	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
NW74_RS05905	COG2255	four-way junction helicase activity
NW74_RS05910	COG0632	four-way junction helicase activity
NW74_RS05915	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
NW74_RS05930	COG1388	LysM domain
NW74_RS05930	COG1705	Flagellar rod assembly protein muramidase FlgJ
NW74_RS05935	COG1115	amino acid carrier protein
NW74_RS05945	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
NW74_RS05950	COG0813	purine-nucleoside phosphorylase activity
NW74_RS05955	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
NW74_RS05955	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
NW74_RS05960	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
NW74_RS05965	COG2195	Cleaves the N-terminal amino acid of tripeptides
NW74_RS05970	COG2195	Cleaves the N-terminal amino acid of tripeptides
NW74_RS05975	COG0484	heat shock protein binding
NW74_RS05995	COG2137	regulation of response to DNA damage stimulus
NW74_RS06040	COG0668	transmembrane transport
NW74_RS06060	COG1077	Cell shape determining protein MreB Mrl
NW74_RS06065	COG1242	4 iron, 4 sulfur cluster binding
NW74_RS06080	COG2226	methyltransferase
NW74_RS06090	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NW74_RS06090	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
NW74_RS06095	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
NW74_RS06100	COG0242	peptide deformylase activity
NW74_RS06105	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
NW74_RS06110	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
NW74_RS06120	COG0194	GDP metabolic process
NW74_RS06125	COG1561	YicC-like family, N-terminal region
NW74_RS06170	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
NW74_RS06180	COG1122	ATPase activity
NW74_RS06185	COG4750	Nucleotidyl transferase
NW74_RS06195	COG3475	LICD family
NW74_RS06200	COG3475	LICD family
NW74_RS06205	COG1216	Glycosyl transferase, family 2
NW74_RS06205	COG1442	glycosyl transferase family 8
NW74_RS06210	COG4509	Sortase family
NW74_RS06215	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NW74_RS06225	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NW74_RS06235	COG0803	Belongs to the bacterial solute-binding protein 9 family
NW74_RS06245	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
NW74_RS06260	COG4555	ABC transporter
NW74_RS06285	COG0101	tRNA pseudouridine synthase activity
NW74_RS06290	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NW74_RS06340	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
NW74_RS06345	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
NW74_RS06350	COG1924	4 iron, 4 sulfur cluster binding
NW74_RS06355	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
NW74_RS06365	COG2195	Cleaves the N-terminal amino acid of tripeptides
NW74_RS06370	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
NW74_RS06375	COG1181	Belongs to the D-alanine--D-alanine ligase family
NW74_RS06395	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
NW74_RS06405	COG1132	(ABC) transporter
NW74_RS06425	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NW74_RS06440	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NW74_RS06445	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
NW74_RS06450	COG0085	RNA polymerase activity
NW74_RS06460	COG0822	iron-sulfur transferase activity
NW74_RS06465	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NW74_RS06470	COG0719	Fe-S assembly protein
NW74_RS06475	COG0719	Fe-S assembly protein
NW74_RS06480	COG0396	ATPase activity
NW74_RS06505	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NW74_RS06510	COG0561	phosphatase activity
NW74_RS06525	COG0564	pseudouridine synthase activity
NW74_RS06535	COG1309	transcriptional regulator
NW74_RS06545	COG2878	Part of a membrane complex involved in electron transport
NW74_RS06545	COG1148	4fe-4S ferredoxin, iron-sulfur binding domain protein
NW74_RS06550	COG4657	Part of a membrane complex involved in electron transport
NW74_RS06555	COG4660	Part of a membrane complex involved in electron transport
NW74_RS06560	COG4659	FMN binding
NW74_RS06565	COG4658	electron transport chain
NW74_RS06570	COG4656	Part of a membrane complex involved in electron transport
NW74_RS06590	COG1242	4 iron, 4 sulfur cluster binding
NW74_RS06595	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
NW74_RS06605	COG3906	Belongs to the UPF0473 family
NW74_RS06615	COG1394	ATPase activity, coupled to movement of substances
NW74_RS06620	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
NW74_RS06630	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
NW74_RS06635	COG1527	subunit (C
NW74_RS06640	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
NW74_RS06645	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NW74_RS06650	COG1269	ATP hydrolysis coupled proton transport
NW74_RS06675	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
NW74_RS06680	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NW74_RS06685	COG0154	amidase activity
NW74_RS06690	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NW74_RS06700	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
NW74_RS06700	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
NW74_RS06710	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NW74_RS06715	COG1028	Short-chain dehydrogenase reductase Sdr
NW74_RS06720	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
NW74_RS06730	COG2070	2-Nitropropane dioxygenase
NW74_RS06735	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NW74_RS06740	COG0825	malonyl-CoA metabolic process
NW74_RS06750	COG0439	Biotin carboxylase
NW74_RS06755	COG0511	ligase activity, forming carbon-carbon bonds
NW74_RS06760	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NW74_RS06790	COG3842	ATPase activity
NW74_RS06795	COG1178	ABC-type Fe3 transport system permease component
NW74_RS06805	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
NW74_RS06810	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NW74_RS06815	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NW74_RS06820	COG1121	(ABC) transporter
NW74_RS06825	COG0803	Belongs to the bacterial solute-binding protein 9 family
NW74_RS06860	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NW74_RS06890	COG0531	amino acid
NW74_RS06895	COG0076	glutamate decarboxylase activity
NW74_RS06950	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
NW74_RS06955	COG0281	malic enzyme
NW74_RS06960	COG1473	amidohydrolase
NW74_RS06965	COG2364	Membrane
NW74_RS06980	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
NW74_RS06990	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
NW74_RS06995	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
NW74_RS07015	COG1114	Component of the transport system for branched-chain amino acids
NW74_RS07020	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
NW74_RS07025	COG0300	oxidoreductase activity
NW74_RS07045	COG1968	undecaprenyl-diphosphatase activity
NW74_RS07065	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NW74_RS07075	COG2116	formate transmembrane transporter activity
NW74_RS07100	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NW74_RS07105	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NW74_RS07110	COG1902	pentaerythritol trinitrate reductase activity
NW74_RS07130	COG1115	amino acid carrier protein
NW74_RS07135	COG0488	(ABC) transporter
NW74_RS07160	COG2252	PERMEase
NW74_RS07170	COG2267	carboxylic ester hydrolase activity
NW74_RS07175	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
NW74_RS07185	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NW74_RS07190	COG1121	(ABC) transporter
NW74_RS07195	COG0735	belongs to the Fur family
NW74_RS07220	COG1329	Transcriptional regulator
NW74_RS07225	COG4956	integral membrane protein (PIN domain superfamily)
NW74_RS07270	COG1132	(ABC) transporter
NW74_RS07275	COG2233	PERMEase
NW74_RS07290	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
NW74_RS07295	COG1494	fructose-1,6-bisphosphatase
NW74_RS07390	COG3340	Belongs to the peptidase S51 family
NW74_RS07400	COG3588	fructose-bisphosphate aldolase
NW74_RS07415	COG4095	Psort location CytoplasmicMembrane, score
NW74_RS07430	COG1956	GAF domain-containing protein
NW74_RS07475	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NW74_RS07480	COG0156	8-amino-7-oxononanoate synthase activity
NW74_RS07490	COG0577	efflux transmembrane transporter activity
NW74_RS07490	COG1136	(ABC) transporter
NW74_RS07495	COG0151	Belongs to the GarS family
NW74_RS07505	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
NW74_RS07510	COG0167	dihydroorotate dehydrogenase activity
NW74_RS07515	COG0543	2 iron, 2 sulfur cluster binding
NW74_RS07520	COG0284	orotidine-5'-phosphate decarboxylase activity
NW74_RS07535	COG0540	Belongs to the ATCase OTCase family
NW74_RS07545	COG1086	Polysaccharide biosynthesis protein
NW74_RS07550	COG1210	Utp--glucose-1-phosphate uridylyltransferase
NW74_RS07555	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NW74_RS07565	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
NW74_RS07570	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NW74_RS07585	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NW74_RS07590	COG0601	transmembrane transport
NW74_RS07595	COG4608	Belongs to the ABC transporter superfamily
NW74_RS07610	COG0315	cyclic pyranopterin monophosphate synthase activity
NW74_RS07615	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
NW74_RS07620	COG3842	ATPase activity
NW74_RS07625	COG4149	molybdate abc transporter
NW74_RS07630	COG0725	ABC transporter, periplasmic molybdate-binding protein
NW74_RS07665	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
NW74_RS07690	COG0741	lytic transglycosylase activity
NW74_RS07700	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
NW74_RS07700	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
NW74_RS07710	COG0587	DNA-directed DNA polymerase activity
NW74_RS07715	COG1293	RNA-binding protein homologous to eukaryotic snRNP