locus-tag	class	description
PB2503_RS00260	COG0513	Belongs to the DEAD box helicase family
PB2503_RS00265	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
PB2503_RS00270	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
PB2503_RS00275	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
PB2503_RS00300	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
PB2503_RS00305	COG0783	Belongs to the Dps family
PB2503_RS00320	COG0360	Binds together with S18 to 16S ribosomal RNA
PB2503_RS00325	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
PB2503_RS00330	COG0359	binds to the 23S rRNA
PB2503_RS00335	COG0305	Participates in initiation and elongation during chromosome replication
PB2503_RS00340	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
PB2503_RS00360	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
PB2503_RS00365	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
PB2503_RS00370	COG4536	flavin adenine dinucleotide binding
PB2503_RS00385	COG0484	heat shock protein binding
PB2503_RS00400	COG0488	(ABC) transporter
PB2503_RS00420	COG0415	Belongs to the DNA photolyase family
PB2503_RS00425	COG0235	Class ii aldolase
PB2503_RS00430	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
PB2503_RS00465	COG1127	ABC transporter
PB2503_RS00470	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
PB2503_RS00490	COG0733	neurotransmitter:sodium symporter activity
PB2503_RS00500	COG0772	Belongs to the SEDS family
PB2503_RS00505	COG0768	penicillin binding
PB2503_RS00535	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
PB2503_RS00540	COG2833	Protein of unknown function (DUF455)
PB2503_RS00575	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
PB2503_RS00590	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
PB2503_RS00610	COG1028	Short-chain dehydrogenase reductase Sdr
PB2503_RS00620	COG0113	porphobilinogen synthase activity
PB2503_RS00625	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
PB2503_RS00630	COG3273	potassium ion transport
PB2503_RS00630	COG0471	metal ion transport
PB2503_RS00635	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
PB2503_RS00640	COG1028	Short-chain dehydrogenase reductase Sdr
PB2503_RS00645	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
PB2503_RS00675	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PB2503_RS00680	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PB2503_RS00695	COG1028	Short-chain dehydrogenase reductase Sdr
PB2503_RS00705	COG0393	Putative heavy-metal-binding
PB2503_RS00720	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PB2503_RS00725	COG0386	Belongs to the glutathione peroxidase family
PB2503_RS00735	COG0039	L-malate dehydrogenase activity
PB2503_RS00745	COG0442	prolyl-tRNA aminoacylation
PB2503_RS00760	COG4251	negative regulation of phosphorylation
PB2503_RS00775	COG2072	flavoprotein involved in K transport
PB2503_RS00780	COG2072	flavoprotein involved in K transport
PB2503_RS00805	COG2963	transposase activity
PB2503_RS00820	COG0438	transferase activity, transferring glycosyl groups
PB2503_RS00825	COG0416	fatty acid biosynthetic process
PB2503_RS00830	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
PB2503_RS00835	COG0776	regulation of translation
PB2503_RS00870	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
PB2503_RS00880	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
PB2503_RS00890	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
PB2503_RS00905	COG2204	response regulator
PB2503_RS00910	COG5000	phosphorelay sensor kinase activity
PB2503_RS00915	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
PB2503_RS00930	COG1573	uracil-dna glycosylase
PB2503_RS00940	COG0741	lytic transglycosylase activity
PB2503_RS00970	COG1522	sequence-specific DNA binding
PB2503_RS00975	COG0659	secondary active sulfate transmembrane transporter activity
PB2503_RS00990	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
PB2503_RS01000	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
PB2503_RS01005	COG0268	Binds directly to 16S ribosomal RNA
PB2503_RS01010	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
PB2503_RS01035	COG0459	protein refolding
PB2503_RS01040	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
PB2503_RS01070	COG1064	alcohol dehydrogenase
PB2503_RS01080	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PB2503_RS01085	COG0590	tRNA wobble adenosine to inosine editing
PB2503_RS01085	COG0037	tRNA processing
PB2503_RS01095	COG1028	Short-chain dehydrogenase reductase Sdr
PB2503_RS01115	COG1970	mechanosensitive ion channel activity
PB2503_RS01120	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
PB2503_RS01130	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
PB2503_RS01145	COG0530	calcium, potassium:sodium antiporter activity
PB2503_RS01155	COG0215	cysteine-tRNA ligase activity
PB2503_RS01160	COG0302	gtp cyclohydrolase
PB2503_RS01170	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
PB2503_RS01195	COG0438	transferase activity, transferring glycosyl groups
PB2503_RS01200	COG1215	transferase activity, transferring glycosyl groups
PB2503_RS01225	COG0539	negative regulation of cytoplasmic translation
PB2503_RS01230	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
PB2503_RS01235	COG1160	GTP binding
PB2503_RS01240	COG0488	(ABC) transporter
PB2503_RS01260	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
PB2503_RS01260	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
PB2503_RS01270	COG0514	ATP-dependent DNA helicase (RecQ)
PB2503_RS01290	COG0519	Catalyzes the synthesis of GMP from XMP
PB2503_RS01305	COG1045	serine acetyltransferase
PB2503_RS01320	COG1692	metallophosphoesterase
PB2503_RS01330	COG1210	Utp--glucose-1-phosphate uridylyltransferase
PB2503_RS01345	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PB2503_RS01350	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
PB2503_RS01360	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PB2503_RS01365	COG0560	Phosphoserine phosphatase
PB2503_RS01365	COG3830	Belongs to the UPF0237 family
PB2503_RS01380	COG0492	ferredoxin-NADP+ reductase activity
PB2503_RS01390	COG0037	tRNA processing
PB2503_RS01400	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
PB2503_RS01425	COG2205	protein histidine kinase activity
PB2503_RS01440	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
PB2503_RS01445	COG2363	Small membrane protein
PB2503_RS01460	COG1793	dna ligase
PB2503_RS01475	COG0556	nucleotide-excision repair
PB2503_RS01490	COG0175	sulfate reduction
PB2503_RS01515	COG0424	maF-like protein
PB2503_RS01520	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
PB2503_RS01530	COG5328	Belongs to the UPF0262 family
PB2503_RS01535	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
PB2503_RS01545	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
PB2503_RS01565	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
PB2503_RS01570	COG3590	peptidase
PB2503_RS01580	COG0183	Belongs to the thiolase family
PB2503_RS01630	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
PB2503_RS01635	COG2189	Belongs to the N(4) N(6)-methyltransferase family
PB2503_RS01655	COG1196	nuclear chromosome segregation
PB2503_RS01670	COG0356	it plays a direct role in the translocation of protons across the membrane
PB2503_RS01680	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
PB2503_RS01690	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
PB2503_RS01745	COG1201	RNA secondary structure unwinding
PB2503_RS01755	COG0018	arginyl-trna synthetase
PB2503_RS01765	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
PB2503_RS01770	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
PB2503_RS01775	COG0328	RNA-DNA hybrid ribonuclease activity
PB2503_RS01785	COG3264	Mechanosensitive ion channel
PB2503_RS01785	COG1196	nuclear chromosome segregation
PB2503_RS01790	COG0602	queuosine metabolic process
PB2503_RS01795	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
PB2503_RS01805	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
PB2503_RS01835	COG0784	Response regulator, receiver
PB2503_RS01835	COG2205	protein histidine kinase activity
PB2503_RS01835	COG5002	protein histidine kinase activity
PB2503_RS01845	COG0646	methionine synthase
PB2503_RS01845	COG1410	methionine synthase
PB2503_RS01855	COG0640	Transcriptional regulator
PB2503_RS01865	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PB2503_RS01870	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
PB2503_RS01875	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
PB2503_RS01880	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
PB2503_RS01885	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
PB2503_RS01890	COG0154	amidase activity
PB2503_RS01900	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
PB2503_RS01910	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
PB2503_RS01915	COG0540	Belongs to the ATCase OTCase family
PB2503_RS01920	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
PB2503_RS01925	COG0174	glutamine synthetase
PB2503_RS01935	COG0784	Response regulator, receiver
PB2503_RS01940	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
PB2503_RS01955	COG3494	Protein of unknown function (DUF1009)
PB2503_RS01965	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
PB2503_RS01970	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PB2503_RS01980	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
PB2503_RS01985	COG0750	zinc metalloprotease
PB2503_RS01990	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
PB2503_RS01995	COG4589	Belongs to the CDS family
PB2503_RS02010	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
PB2503_RS02015	COG0233	cytoplasmic translational termination
PB2503_RS02020	COG0528	UMP kinase activity
PB2503_RS02030	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
PB2503_RS02035	COG0052	Belongs to the universal ribosomal protein uS2 family
PB2503_RS02060	COG0519	Catalyzes the synthesis of GMP from XMP
PB2503_RS02065	COG2814	Major facilitator Superfamily
PB2503_RS02085	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
PB2503_RS02100	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
PB2503_RS02115	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
PB2503_RS02115	COG0574	Belongs to the PEP-utilizing enzyme family
PB2503_RS02120	COG0751	glycine-tRNA ligase activity
PB2503_RS02125	COG0463	Glycosyl transferase, family 2
PB2503_RS02140	COG2718	Belongs to the UPF0229 family
PB2503_RS02155	COG2719	SpoVR family
PB2503_RS02165	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
PB2503_RS02170	COG0752	glycyl-tRNA synthetase alpha subunit
PB2503_RS02185	COG0196	riboflavin kinase activity
PB2503_RS02190	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
PB2503_RS02195	COG0632	four-way junction helicase activity
PB2503_RS02200	COG2255	four-way junction helicase activity
PB2503_RS02205	COG0824	Thioesterase
PB2503_RS02210	COG0302	gtp cyclohydrolase
PB2503_RS02215	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
PB2503_RS02240	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
PB2503_RS02245	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
PB2503_RS02255	COG0352	thiamine-phosphate diphosphorylase activity
PB2503_RS02260	COG3588	fructose-bisphosphate aldolase
PB2503_RS02265	COG0126	phosphoglycerate kinase activity
PB2503_RS02275	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
PB2503_RS02320	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
PB2503_RS02345	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PB2503_RS02375	COG0257	Belongs to the bacterial ribosomal protein bL36 family
PB2503_RS02385	COG1960	acyl-CoA dehydrogenase activity
PB2503_RS02400	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
PB2503_RS02435	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
PB2503_RS02445	COG0138	bifunctional purine biosynthesis protein purh
PB2503_RS02450	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
PB2503_RS02475	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
PB2503_RS02480	COG0792	nuclease activity
PB2503_RS02495	COG0784	Response regulator, receiver
PB2503_RS02495	COG5002	protein histidine kinase activity
PB2503_RS02495	COG2205	protein histidine kinase activity
PB2503_RS02500	COG0635	Involved in the biosynthesis of porphyrin-containing compound
PB2503_RS02505	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
PB2503_RS02510	COG0820	rRNA (adenine-C2-)-methyltransferase activity
PB2503_RS02535	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
PB2503_RS02540	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
PB2503_RS02545	COG0181	hydroxymethylbilane synthase activity
PB2503_RS02570	COG1074	ATP-dependent DNA helicase activity
PB2503_RS02580	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
PB2503_RS02585	COG3178	'Phosphotransferase
PB2503_RS02590	COG0802	atpase or kinase
PB2503_RS02595	COG0633	Ferredoxin
PB2503_RS02605	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
PB2503_RS02610	COG4771	TonB-dependent receptor
PB2503_RS02620	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
PB2503_RS02625	COG0366	Alpha amylase catalytic
PB2503_RS02635	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
PB2503_RS02640	COG2079	MmgE PrpD family protein
PB2503_RS02680	COG5265	(ABC) transporter
PB2503_RS02685	COG2166	iron-sulfur cluster assembly
PB2503_RS02690	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
PB2503_RS02705	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
PB2503_RS02720	COG0312	modulator of DNA gyrase
PB2503_RS02730	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PB2503_RS02735	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
PB2503_RS02740	COG0651	ATP synthesis coupled electron transport
PB2503_RS02750	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
PB2503_RS02755	COG0651	ATP synthesis coupled electron transport
PB2503_RS02775	COG1320	monovalent cation:proton antiporter activity
PB2503_RS02780	COG2212	antiporter activity
PB2503_RS02785	COG1863	multisubunit Na H antiporter MnhE subunit
PB2503_RS02800	COG0333	Belongs to the bacterial ribosomal protein bL32 family
PB2503_RS02815	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
PB2503_RS02820	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
PB2503_RS02850	COG2866	Carboxypeptidase
PB2503_RS02855	COG0024	Methionine aminopeptidase
PB2503_RS02860	COG2003	Belongs to the UPF0758 family
PB2503_RS02875	COG2885	chlorophyll binding
PB2503_RS02880	COG0823	Involved in the tonB-independent uptake of proteins
PB2503_RS02900	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
PB2503_RS02920	COG2962	Rard protein
PB2503_RS02930	COG0564	pseudouridine synthase activity
PB2503_RS02955	COG0640	Transcriptional regulator
PB2503_RS02960	COG0450	alkyl hydroperoxide reductase
PB2503_RS02990	COG1733	regulation of RNA biosynthetic process
PB2503_RS03000	COG4941	Belongs to the sigma-70 factor family
PB2503_RS03045	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
PB2503_RS03105	COG2948	multi-organism process
PB2503_RS03110	COG3504	Conjugal transfer protein
PB2503_RS03130	COG3451	type IV secretory pathway VirB4
PB2503_RS03145	COG4962	Type ii secretion system protein e
PB2503_RS03205	COG1475	DNA binding
PB2503_RS03235	COG1959	2 iron, 2 sulfur cluster binding
PB2503_RS03240	COG3273	potassium ion transport
PB2503_RS03240	COG0471	metal ion transport
PB2503_RS03250	COG4771	TonB-dependent receptor
PB2503_RS03255	COG0471	metal ion transport
PB2503_RS03255	COG3273	potassium ion transport
PB2503_RS03275	COG3118	belongs to the thioredoxin family
PB2503_RS03280	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
PB2503_RS03285	COG2835	tetraacyldisaccharide 4'-kinase activity
PB2503_RS03295	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
PB2503_RS03310	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
PB2503_RS03325	COG4221	oxidoreductase activity
PB2503_RS03335	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
PB2503_RS03340	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
PB2503_RS03355	COG3920	Histidine kinase
PB2503_RS03360	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
PB2503_RS03365	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
PB2503_RS03375	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
PB2503_RS03415	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
PB2503_RS03420	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PB2503_RS03425	COG0784	Response regulator, receiver
PB2503_RS03425	COG2205	protein histidine kinase activity
PB2503_RS03425	COG2198	Histidine kinase
PB2503_RS03430	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
PB2503_RS03445	COG3040	lipid binding
PB2503_RS03450	COG2816	NAD+ diphosphatase activity
PB2503_RS03460	COG3474	cytochrome
PB2503_RS03475	COG1619	proteins homologs of microcin C7 resistance protein MccF
PB2503_RS03480	COG1846	Transcriptional regulator
PB2503_RS03485	COG2171	N-acyltransferase activity
PB2503_RS03500	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
PB2503_RS03505	COG2154	pterin-4-alpha-carbinolamine dehydratase
PB2503_RS03510	COG0745	RESPONSE REGULATOR receiver
PB2503_RS03515	COG2205	protein histidine kinase activity
PB2503_RS03525	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
PB2503_RS03525	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PB2503_RS03530	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
PB2503_RS03550	COG0481	GTPase activity
PB2503_RS03560	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
PB2503_RS03565	COG4133	protoheme IX ABC transporter activity
PB2503_RS03595	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
PB2503_RS03600	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
PB2503_RS03605	COG0552	protein localization to endoplasmic reticulum
PB2503_RS03660	COG1674	ftsk spoiiie
PB2503_RS03670	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PB2503_RS03680	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
PB2503_RS03705	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
PB2503_RS03715	COG1420	regulation of RNA biosynthetic process
PB2503_RS03720	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
PB2503_RS03745	COG0284	orotidine-5'-phosphate decarboxylase activity
PB2503_RS03750	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
PB2503_RS03770	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
PB2503_RS03775	COG1702	phosphate starvation-inducible protein PhoH
PB2503_RS03780	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
PB2503_RS03785	COG1253	flavin adenine dinucleotide binding
PB2503_RS03795	COG1396	sequence-specific DNA binding
PB2503_RS03800	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
PB2503_RS03805	COG0220	tRNA (guanine-N7-)-methyltransferase activity
PB2503_RS03820	COG0779	Required for maturation of 30S ribosomal subunits
PB2503_RS03825	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
PB2503_RS03825	COG0195	Participates in both transcription termination and antitermination
PB2503_RS03875	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
PB2503_RS03875	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
PB2503_RS03885	COG0501	Belongs to the peptidase M48B family
PB2503_RS03900	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
PB2503_RS03905	COG0237	dephospho-CoA kinase activity
PB2503_RS03910	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
PB2503_RS03915	COG0424	maF-like protein
PB2503_RS03920	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
PB2503_RS03925	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
PB2503_RS03930	COG1981	membrane
PB2503_RS03935	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
PB2503_RS03950	COG0584	glycerophosphoryl diester phosphodiesterase
PB2503_RS03960	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
PB2503_RS03965	COG0445	tRNA wobble uridine modification
PB2503_RS03970	COG0357	Ribosomal RNA small subunit methyltransferase G
PB2503_RS03990	COG0123	including yeast histone deacetylase and acetoin utilization protein
PB2503_RS03995	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
PB2503_RS04005	COG1505	serine-type exopeptidase activity
PB2503_RS04010	COG1301	dicarboxylic acid transport
PB2503_RS04020	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
PB2503_RS04030	COG0228	four-way junction DNA binding
PB2503_RS04035	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
PB2503_RS04045	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PB2503_RS04045	COG0072	phenylalanine-tRNA ligase activity
PB2503_RS04050	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
PB2503_RS04055	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
PB2503_RS04060	COG0291	Belongs to the bacterial ribosomal protein bL35 family
PB2503_RS04075	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
PB2503_RS04090	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
PB2503_RS04100	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
PB2503_RS04110	COG0285	dihydrofolate synthase activity
PB2503_RS04115	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
PB2503_RS04120	COG0159	tryptophan synthase activity
PB2503_RS04130	COG0133	tryptophan synthase activity
PB2503_RS04145	COG0776	regulation of translation
PB2503_RS04155	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
PB2503_RS04160	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
PB2503_RS04170	COG1131	(ABC) transporter
PB2503_RS04190	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
PB2503_RS04195	COG0463	Glycosyl transferase, family 2
PB2503_RS04200	COG0287	Prephenate dehydrogenase
PB2503_RS04205	COG0335	large ribosomal subunit rRNA binding
PB2503_RS04210	COG0336	Belongs to the RNA methyltransferase TrmD family
PB2503_RS04215	COG0612	Peptidase, M16
PB2503_RS04230	COG0495	leucyl-tRNA aminoacylation
PB2503_RS04235	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
PB2503_RS04245	COG1984	allophanate hydrolase subunit 2
PB2503_RS04265	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
PB2503_RS04290	COG1115	amino acid carrier protein
PB2503_RS04305	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
PB2503_RS04315	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
PB2503_RS04370	COG2321	neutral zinc metallopeptidase
PB2503_RS04375	COG0280	phosphate acetyltransferase
PB2503_RS04375	COG0281	malic enzyme
PB2503_RS04385	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
PB2503_RS04415	COG2957	Belongs to the agmatine deiminase family
PB2503_RS04435	COG2943	transferase activity, transferring hexosyl groups
PB2503_RS04440	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
PB2503_RS04445	COG5592	hemerythrin HHE cation binding domain
PB2503_RS04455	COG1764	response to oxidative stress
PB2503_RS04465	COG2133	pyrroloquinoline quinone binding
PB2503_RS04480	COG0583	DNA-binding transcription factor activity
PB2503_RS04485	COG1648	precorrin-2 dehydrogenase activity
PB2503_RS04485	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
PB2503_RS04495	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PB2503_RS04505	COG0175	sulfate reduction
PB2503_RS04510	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
PB2503_RS04520	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
PB2503_RS04530	COG0101	tRNA pseudouridine synthase activity
PB2503_RS04535	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
PB2503_RS04540	COG0242	peptide deformylase activity
PB2503_RS04550	COG0156	8-amino-7-oxononanoate synthase activity
PB2503_RS04555	COG0318	PFAM AMP-dependent synthetase and ligase
PB2503_RS04560	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PB2503_RS04580	COG0156	8-amino-7-oxononanoate synthase activity
PB2503_RS04590	COG4206	TonB-dependent receptor
PB2503_RS04615	COG0494	nUDIX hydrolase
PB2503_RS04630	COG0019	diaminopimelate decarboxylase activity
PB2503_RS04640	COG2353	YceI-like domain
PB2503_RS04650	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
PB2503_RS04655	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
PB2503_RS04660	COG1262	PFAM Formylglycine-generating sulfatase enzyme
PB2503_RS04665	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
PB2503_RS04675	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
PB2503_RS04685	COG0793	Belongs to the peptidase S41A family
PB2503_RS04690	COG0861	Integral membrane protein TerC family
PB2503_RS04705	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
PB2503_RS04710	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
PB2503_RS04720	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
PB2503_RS04725	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
PB2503_RS04745	COG0355	proton-transporting ATP synthase activity, rotational mechanism
PB2503_RS04755	COG1138	Cytochrome C-type biogenesis protein
PB2503_RS04760	COG3088	subunit of a heme lyase
PB2503_RS04765	COG1250	3-hydroxyacyl-CoA dehydrogenase
PB2503_RS04780	COG2169	Transcriptional regulator
PB2503_RS04780	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
PB2503_RS04790	COG0670	Belongs to the BI1 family
PB2503_RS04830	COG0261	This protein binds to 23S rRNA in the presence of protein L20
PB2503_RS04835	COG0211	Belongs to the bacterial ribosomal protein bL27 family
PB2503_RS04840	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
PB2503_RS04845	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
PB2503_RS04850	COG0702	epimerase
PB2503_RS04885	COG4964	Belongs to the GSP D family
PB2503_RS04890	COG5461	TIGRFAM pilus (Caulobacter type) biogenesis lipoprotein CpaD
PB2503_RS04920	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
PB2503_RS04925	COG2205	protein histidine kinase activity
PB2503_RS04940	COG0842	Transport permease protein
PB2503_RS04970	COG1185	polyribonucleotide nucleotidyltransferase activity
PB2503_RS04980	COG1272	protein, Hemolysin III
PB2503_RS04990	COG0189	ligase activity
PB2503_RS04995	COG0140	phosphoribosyl-ATP diphosphatase activity
PB2503_RS05000	COG0107	imidazoleglycerol-phosphate synthase activity
PB2503_RS05005	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
PB2503_RS05010	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
PB2503_RS05030	COG0131	Imidazoleglycerol-phosphate dehydratase
PB2503_RS05045	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
PB2503_RS05050	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
PB2503_RS05055	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PB2503_RS05065	COG2223	nitrite transmembrane transporter activity
PB2503_RS05070	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
PB2503_RS05075	COG4251	negative regulation of phosphorylation
PB2503_RS05085	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
PB2503_RS05085	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
PB2503_RS05205	COG2963	transposase activity
PB2503_RS05215	COG4962	Type ii secretion system protein e
PB2503_RS05230	COG3451	type IV secretory pathway VirB4
PB2503_RS05240	COG3846	protein secretion by the type IV secretion system
PB2503_RS05255	COG2948	multi-organism process
PB2503_RS05265	COG5489	Protein of unknown function (DUF736)
PB2503_RS05345	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
PB2503_RS05420	COG1475	DNA binding
PB2503_RS05450	COG4974	Belongs to the 'phage' integrase family
PB2503_RS05515	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
PB2503_RS05590	COG1024	Enoyl-CoA hydratase
PB2503_RS05600	COG0583	DNA-binding transcription factor activity
PB2503_RS05615	COG2963	transposase activity
PB2503_RS05635	COG2963	transposase activity
PB2503_RS05645	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PB2503_RS05675	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
PB2503_RS05690	COG0659	secondary active sulfate transmembrane transporter activity
PB2503_RS05720	COG0483	inositol monophosphate 1-phosphatase activity
PB2503_RS05735	COG0728	peptidoglycan biosynthetic process
PB2503_RS05745	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
PB2503_RS05750	COG0450	alkyl hydroperoxide reductase
PB2503_RS05755	COG0583	DNA-binding transcription factor activity
PB2503_RS05775	COG0436	Aminotransferase
PB2503_RS05790	COG0066	3-isopropylmalate dehydratase activity
PB2503_RS05795	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
PB2503_RS05800	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
PB2503_RS05805	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
PB2503_RS05820	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
PB2503_RS05825	COG0129	dihydroxy-acid dehydratase activity
PB2503_RS05850	COG1137	ATPase activity
PB2503_RS05855	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
PB2503_RS05860	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
PB2503_RS05865	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
PB2503_RS05875	COG1968	undecaprenyl-diphosphatase activity
PB2503_RS05880	COG1596	polysaccharide export
PB2503_RS05890	COG0489	protein tyrosine kinase activity
PB2503_RS05890	COG3206	protein involved in exopolysaccharide biosynthesis
PB2503_RS05905	COG0180	Tryptophanyl-tRNA synthetase
PB2503_RS05920	COG0745	RESPONSE REGULATOR receiver
PB2503_RS05925	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
PB2503_RS05930	COG2967	ApaG domain
PB2503_RS05960	COG0811	peptide transport
PB2503_RS05965	COG0811	peptide transport
PB2503_RS05970	COG0848	biopolymer transport protein
PB2503_RS05975	COG0848	biopolymer transport protein
PB2503_RS05990	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
PB2503_RS05990	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PB2503_RS05995	COG2951	lytic endotransglycosylase activity
PB2503_RS06010	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
PB2503_RS06025	COG4251	negative regulation of phosphorylation
PB2503_RS06055	COG1024	Enoyl-CoA hydratase
PB2503_RS06080	COG1295	ribonuclease BN
PB2503_RS06090	COG2884	Cell division ATP-binding protein ftsE
PB2503_RS06105	COG1322	Protein conserved in bacteria
PB2503_RS06135	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
PB2503_RS06145	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
PB2503_RS06150	COG1218	3'(2'),5'-bisphosphate nucleotidase
PB2503_RS06165	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
PB2503_RS06170	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
PB2503_RS06180	COG0534	Mate efflux family protein
PB2503_RS06195	COG0254	rRNA binding
PB2503_RS06230	COG0312	modulator of DNA gyrase
PB2503_RS06235	COG0404	The glycine cleavage system catalyzes the degradation of glycine
PB2503_RS06240	COG0509	glycine decarboxylation via glycine cleavage system
PB2503_RS06245	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
PB2503_RS06250	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
PB2503_RS06255	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
PB2503_RS06295	COG0463	Glycosyl transferase, family 2
PB2503_RS06325	COG0489	protein tyrosine kinase activity
PB2503_RS06325	COG3206	protein involved in exopolysaccharide biosynthesis
PB2503_RS06335	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
PB2503_RS06340	COG1596	polysaccharide export
PB2503_RS06380	COG0542	response to heat
PB2503_RS06390	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PB2503_RS06390	COG3153	acetyltransferase
PB2503_RS06405	COG0656	L-ascorbic acid biosynthetic process
PB2503_RS06415	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
PB2503_RS06445	COG1956	GAF domain-containing protein
PB2503_RS06465	COG2267	carboxylic ester hydrolase activity
PB2503_RS06490	COG2066	Belongs to the glutaminase family
PB2503_RS06505	COG0579	oxidoreductase
PB2503_RS06515	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
PB2503_RS06520	COG1278	Cold shock
PB2503_RS06530	COG3268	Saccharopine dehydrogenase
PB2503_RS06550	COG0662	Cupin 2, conserved barrel domain protein
PB2503_RS06560	COG0183	Belongs to the thiolase family
PB2503_RS06575	COG0564	pseudouridine synthase activity
PB2503_RS06580	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
PB2503_RS06585	COG1902	pentaerythritol trinitrate reductase activity
PB2503_RS06605	COG0316	Belongs to the HesB IscA family
PB2503_RS06610	COG0232	Belongs to the dGTPase family. Type 2 subfamily
PB2503_RS06620	COG1472	Belongs to the glycosyl hydrolase 3 family
PB2503_RS06625	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
PB2503_RS06630	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
PB2503_RS06635	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
PB2503_RS06645	COG0805	protein transport
PB2503_RS06655	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
PB2503_RS06660	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
PB2503_RS06670	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
PB2503_RS06675	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
PB2503_RS06700	COG1757	Na H antiporter
PB2503_RS06715	COG2766	serine protein kinase
PB2503_RS06730	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
PB2503_RS06740	COG0189	ligase activity
PB2503_RS06740	COG4067	protein conserved in archaea
PB2503_RS06745	COG0167	dihydroorotate dehydrogenase activity
PB2503_RS06750	COG0784	Response regulator, receiver
PB2503_RS06750	COG2205	protein histidine kinase activity
PB2503_RS06760	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
PB2503_RS06775	COG1741	Belongs to the pirin family
PB2503_RS06795	COG0321	lipoyl(octanoyl) transferase activity
PB2503_RS06805	COG4166	transmembrane transport
PB2503_RS06810	COG0601	transmembrane transport
PB2503_RS06815	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PB2503_RS06820	COG4172	Belongs to the ABC transporter superfamily
PB2503_RS06850	COG4191	Histidine kinase
PB2503_RS06855	COG4566	intracellular signal transduction
PB2503_RS06870	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
PB2503_RS06875	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PB2503_RS06910	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PB2503_RS06915	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PB2503_RS06925	COG3321	synthase
PB2503_RS06925	COG0604	alcohol dehydrogenase
PB2503_RS06940	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PB2503_RS06975	COG0784	Response regulator, receiver
PB2503_RS06975	COG2205	protein histidine kinase activity
PB2503_RS07010	COG2197	response regulator
PB2503_RS07025	COG0745	RESPONSE REGULATOR receiver
PB2503_RS07030	COG2201	protein-glutamate methylesterase activity
PB2503_RS07035	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
PB2503_RS07040	COG2963	transposase activity
PB2503_RS07055	COG0835	chemotaxis
PB2503_RS07060	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
PB2503_RS07065	COG0745	RESPONSE REGULATOR receiver
PB2503_RS07075	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
PB2503_RS07090	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
PB2503_RS07095	COG0457	Tetratricopeptide repeat
PB2503_RS07120	COG2197	response regulator
PB2503_RS07125	COG2205	protein histidine kinase activity
PB2503_RS07130	COG0745	RESPONSE REGULATOR receiver
PB2503_RS07135	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
PB2503_RS07140	COG1518	maintenance of DNA repeat elements
PB2503_RS07185	COG0217	transcriptional regulatory protein
PB2503_RS07190	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
PB2503_RS07195	COG2200	EAL domain
PB2503_RS07195	COG2199	diguanylate cyclase activity
PB2503_RS07195	COG3287	FIST C domain
PB2503_RS07205	COG0463	Glycosyl transferase, family 2
PB2503_RS07215	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
PB2503_RS07220	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
PB2503_RS07235	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
PB2503_RS07250	COG1960	acyl-CoA dehydrogenase activity
PB2503_RS07255	COG2885	chlorophyll binding
PB2503_RS07260	COG1187	pseudouridine synthase activity
PB2503_RS07265	COG0742	ribosomal rna small subunit methyltransferase
PB2503_RS07275	COG0535	radical SAM domain protein
PB2503_RS07305	COG1749	Flagellar hook protein flgE
PB2503_RS07310	COG1256	bacterial-type flagellum assembly
PB2503_RS07320	COG1706	bacterial-type flagellum-dependent cell motility
PB2503_RS07330	COG1338	Plays a role in the flagellum-specific transport system
PB2503_RS07365	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
PB2503_RS07370	COG4786	Flagellar basal body rod
PB2503_RS07375	COG4786	Flagellar basal body rod
PB2503_RS07385	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
PB2503_RS07445	COG1677	Flagellar hook-basal body complex protein FliE
PB2503_RS07455	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
PB2503_RS07460	COG1684	flagellar biosynthetic protein fliR
PB2503_RS07465	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
PB2503_RS07470	COG0626	cystathionine gamma-synthase activity
PB2503_RS07485	COG0405	Gamma-glutamyltransferase
PB2503_RS07490	COG3191	aminopeptidase activity
PB2503_RS07505	COG1573	uracil-dna glycosylase
PB2503_RS07515	COG2205	protein histidine kinase activity
PB2503_RS07530	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
PB2503_RS07535	COG2983	Belongs to the UPF0260 family
PB2503_RS07550	COG4695	Portal protein
PB2503_RS07620	COG0484	heat shock protein binding
PB2503_RS07625	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PB2503_RS07630	COG0745	RESPONSE REGULATOR receiver
PB2503_RS07640	COG0776	regulation of translation
PB2503_RS07645	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
PB2503_RS07665	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
PB2503_RS07680	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
PB2503_RS07690	COG3474	cytochrome
PB2503_RS07695	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
PB2503_RS07705	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
PB2503_RS07740	COG0339	signal peptide processing
PB2503_RS07745	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
PB2503_RS07750	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
PB2503_RS07760	COG1522	sequence-specific DNA binding
PB2503_RS07770	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PB2503_RS07780	COG0038	chloride channel
PB2503_RS07790	COG0037	tRNA processing
PB2503_RS07795	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PB2503_RS07815	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
PB2503_RS07820	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PB2503_RS07825	COG0351	phosphomethylpyrimidine kinase
PB2503_RS07830	COG1573	uracil-dna glycosylase
PB2503_RS07840	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
PB2503_RS07845	COG1758	RNA polymerase activity
PB2503_RS07855	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
PB2503_RS07860	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
PB2503_RS07865	COG0736	holo-[acyl-carrier-protein] synthase activity
PB2503_RS07870	COG0681	Belongs to the peptidase S26 family
PB2503_RS07880	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
PB2503_RS07890	COG0322	excinuclease ABC activity
PB2503_RS07900	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
PB2503_RS07905	COG1278	Cold shock
PB2503_RS07920	COG1233	COG1233 Phytoene dehydrogenase and related
PB2503_RS07935	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
PB2503_RS07960	COG0604	alcohol dehydrogenase
PB2503_RS07960	COG3321	synthase
PB2503_RS07960	COG1028	Short-chain dehydrogenase reductase Sdr
PB2503_RS07965	COG2271	Major facilitator Superfamily
PB2503_RS07975	COG1419	protein localization to endoplasmic reticulum
PB2503_RS07985	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
PB2503_RS07990	COG4771	TonB-dependent receptor
PB2503_RS08005	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
PB2503_RS08010	COG4774	siderophore transport
PB2503_RS08020	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
PB2503_RS08045	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
PB2503_RS08075	COG1459	type II secretion system
PB2503_RS08125	COG1230	cation diffusion facilitator family transporter
PB2503_RS08140	COG0432	Pfam Uncharacterised protein family UPF0047
PB2503_RS08145	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
PB2503_RS08160	COG0009	L-threonylcarbamoyladenylate synthase
PB2503_RS08165	COG1960	acyl-CoA dehydrogenase activity
PB2503_RS08180	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
PB2503_RS08185	COG1496	oxidoreductase activity
PB2503_RS08195	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
PB2503_RS08210	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
PB2503_RS08225	COG1722	exodeoxyribonuclease VII activity
PB2503_RS08230	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
PB2503_RS08240	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
PB2503_RS08245	COG2226	methyltransferase
PB2503_RS08245	COG1073	alpha beta
PB2503_RS08270	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
PB2503_RS08275	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
PB2503_RS08290	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
PB2503_RS08295	COG0248	Ppx GppA phosphatase
PB2503_RS08300	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
PB2503_RS08315	COG0508	dehydrogenase complex catalyzes the overall conversion of
PB2503_RS08315	COG0022	dehydrogenase e1 component
PB2503_RS08330	COG0508	dehydrogenase complex catalyzes the overall conversion of
PB2503_RS08340	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PB2503_RS08355	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
PB2503_RS08400	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PB2503_RS08415	COG3104	oligopeptide transport
PB2503_RS08420	COG0483	inositol monophosphate 1-phosphatase activity
PB2503_RS08425	COG1396	sequence-specific DNA binding
PB2503_RS08430	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
PB2503_RS08445	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
PB2503_RS08460	COG0837	glucose binding
PB2503_RS08475	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
PB2503_RS08485	COG0745	RESPONSE REGULATOR receiver
PB2503_RS08490	COG1666	GTP binding
PB2503_RS08510	COG0330	HflC and HflK could
PB2503_RS08530	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
PB2503_RS08535	COG0047	phosphoribosylformylglycinamidine synthase activity
PB2503_RS08550	COG0267	Belongs to the bacterial ribosomal protein bL33 family
PB2503_RS08560	COG2814	Major facilitator Superfamily
PB2503_RS08575	COG2226	methyltransferase
PB2503_RS08580	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
PB2503_RS08590	COG0497	DNA recombination
PB2503_RS08595	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
PB2503_RS08600	COG4221	oxidoreductase activity
PB2503_RS08605	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PB2503_RS08620	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
PB2503_RS08630	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PB2503_RS08635	COG5002	protein histidine kinase activity
PB2503_RS08650	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PB2503_RS08670	COG0415	Belongs to the DNA photolyase family
PB2503_RS08685	COG2308	Evidence 4 Homologs of previously reported genes of
PB2503_RS08695	COG2877	3-deoxy-8-phosphooctulonate synthase activity
PB2503_RS08725	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
PB2503_RS08735	COG0697	spore germination
PB2503_RS08740	COG1846	Transcriptional regulator
PB2503_RS08755	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PB2503_RS08760	COG0012	GTP binding
PB2503_RS08765	COG0193	aminoacyl-tRNA hydrolase activity
PB2503_RS08775	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
PB2503_RS08785	COG3932	Exopolysaccharide synthesis, ExoD
PB2503_RS08800	COG0739	heme binding
PB2503_RS08810	COG1058	Belongs to the CinA family
PB2503_RS08810	COG1546	Belongs to the CinA family
PB2503_RS08815	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
PB2503_RS08815	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
PB2503_RS08825	COG0534	Mate efflux family protein
PB2503_RS08845	COG0222	ribosome binding
PB2503_RS08850	COG0085	RNA polymerase activity
PB2503_RS08855	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
PB2503_RS08875	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
PB2503_RS08880	COG0049	tRNA binding
PB2503_RS08885	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
PB2503_RS08890	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
PB2503_RS08895	COG0051	transcription antitermination factor activity, RNA binding
PB2503_RS08900	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
PB2503_RS08905	COG0088	Forms part of the polypeptide exit tunnel
PB2503_RS08910	COG0089	rRNA binding
PB2503_RS08915	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
PB2503_RS08920	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
PB2503_RS08925	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
PB2503_RS08930	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
PB2503_RS08935	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
PB2503_RS08940	COG0255	Belongs to the universal ribosomal protein uL29 family
PB2503_RS08945	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
PB2503_RS08950	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
PB2503_RS08955	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
PB2503_RS08960	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
PB2503_RS08965	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
PB2503_RS08970	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
PB2503_RS08975	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
PB2503_RS08985	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
PB2503_RS08990	COG1841	ribosomal large subunit assembly
PB2503_RS08995	COG0200	Binds to the 23S rRNA
PB2503_RS09005	COG0563	adenylate kinase activity
PB2503_RS09010	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
PB2503_RS09015	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
PB2503_RS09020	COG0202	RNA polymerase activity
PB2503_RS09025	COG0203	ribosomal protein L17
PB2503_RS09030	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PB2503_RS09035	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
PB2503_RS09045	COG4974	Belongs to the 'phage' integrase family
PB2503_RS09050	COG0825	malonyl-CoA metabolic process
PB2503_RS09060	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
PB2503_RS09065	COG2323	membrane
PB2503_RS09070	COG0187	DNA topoisomerase II activity
PB2503_RS09080	COG1489	DNA binding
PB2503_RS09090	COG0483	inositol monophosphate 1-phosphatase activity
PB2503_RS09100	COG4771	TonB-dependent receptor
PB2503_RS09110	COG3956	TIGRFAM MazG family protein
PB2503_RS09125	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
PB2503_RS09150	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
PB2503_RS09160	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
PB2503_RS09165	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
PB2503_RS09175	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
PB2503_RS09180	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
PB2503_RS09185	COG0812	UDP-N-acetylmuramate dehydrogenase activity
PB2503_RS09190	COG1181	Belongs to the D-alanine--D-alanine ligase family
PB2503_RS09195	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
PB2503_RS09210	COG0439	Biotin carboxylase
PB2503_RS09215	COG0511	ligase activity, forming carbon-carbon bonds
PB2503_RS09225	COG2022	thiamine diphosphate biosynthetic process
PB2503_RS09230	COG0596	Alpha beta hydrolase
PB2503_RS09235	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
PB2503_RS09235	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
PB2503_RS09240	COG0501	Belongs to the peptidase M48B family
PB2503_RS09245	COG1530	ribonuclease E activity
PB2503_RS09245	COG1530	ribonuclease E activity
PB2503_RS09260	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
PB2503_RS09270	COG0142	geranyltranstransferase activity
PB2503_RS09290	COG0596	Alpha beta hydrolase
PB2503_RS09305	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
PB2503_RS09320	COG1702	phosphate starvation-inducible protein PhoH
PB2503_RS09325	COG3038	cytochrome b561
PB2503_RS09330	COG2945	thiolester hydrolase activity
PB2503_RS09335	COG1959	2 iron, 2 sulfur cluster binding
PB2503_RS09345	COG0719	Fe-S assembly protein
PB2503_RS09355	COG0396	ATPase activity
PB2503_RS09360	COG0719	Fe-S assembly protein
PB2503_RS09380	COG2151	metal-sulfur cluster biosynthetic enzyme
PB2503_RS09385	COG0316	Belongs to the HesB IscA family
PB2503_RS09410	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
PB2503_RS09435	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
PB2503_RS09440	COG0081	regulation of translation
PB2503_RS09470	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
PB2503_RS09485	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
PB2503_RS09495	COG2890	protein-(glutamine-N5) methyltransferase activity
PB2503_RS09500	COG0406	alpha-ribazole phosphatase activity
PB2503_RS09510	COG0567	Dehydrogenase, E1 component
PB2503_RS09515	COG0508	dehydrogenase complex catalyzes the overall conversion of
PB2503_RS09520	COG0518	GMP synthase (glutamine-hydrolyzing) activity
PB2503_RS09520	COG0519	Catalyzes the synthesis of GMP from XMP
PB2503_RS09525	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PB2503_RS09530	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
PB2503_RS09575	COG4251	negative regulation of phosphorylation
PB2503_RS09590	COG0784	Response regulator, receiver
PB2503_RS09620	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PB2503_RS09625	COG1741	Belongs to the pirin family
PB2503_RS09650	COG1494	fructose-1,6-bisphosphatase
PB2503_RS09665	COG2032	superoxide dismutase activity
PB2503_RS09670	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
PB2503_RS09675	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
PB2503_RS09690	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
PB2503_RS09705	COG4771	TonB-dependent receptor
PB2503_RS09715	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
PB2503_RS09725	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
PB2503_RS09730	COG1372	Participates in initiation and elongation during chromosome replication
PB2503_RS09730	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
PB2503_RS09740	COG1686	Belongs to the peptidase S11 family
PB2503_RS09750	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
PB2503_RS09770	COG0482	sulfurtransferase activity
PB2503_RS09780	COG0045	succinate-CoA ligase (ADP-forming) activity
PB2503_RS09785	COG1862	Preprotein translocase
PB2503_RS09820	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
PB2503_RS09845	COG0546	phosphoglycolate phosphatase activity
PB2503_RS09850	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
PB2503_RS09855	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
PB2503_RS09860	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
PB2503_RS09865	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
PB2503_RS09875	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
PB2503_RS09880	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
PB2503_RS09905	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
PB2503_RS09925	COG0438	transferase activity, transferring glycosyl groups
PB2503_RS09930	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
PB2503_RS09950	COG0489	protein tyrosine kinase activity
PB2503_RS09995	COG0408	coproporphyrinogen oxidase activity
PB2503_RS10000	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
PB2503_RS10015	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
PB2503_RS10035	COG1028	Short-chain dehydrogenase reductase Sdr
PB2503_RS10045	COG0124	histidyl-tRNA synthetase
PB2503_RS10055	COG1217	gtp-binding protein TYPA
PB2503_RS10060	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
PB2503_RS10075	COG2857	Cytochrome c1
PB2503_RS10075	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
PB2503_RS10080	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
PB2503_RS10110	COG0105	UTP biosynthetic process
PB2503_RS10120	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PB2503_RS10125	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
PB2503_RS10140	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
PB2503_RS10145	COG0557	exoribonuclease II activity
PB2503_RS10160	COG0227	Belongs to the bacterial ribosomal protein bL28 family
PB2503_RS10185	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PB2503_RS10200	COG2244	polysaccharide biosynthetic process
PB2503_RS10215	COG2205	protein histidine kinase activity
PB2503_RS10220	COG3920	Histidine kinase
PB2503_RS10225	COG0006	proline dipeptidase activity
PB2503_RS10225	COG0006	proline dipeptidase activity
PB2503_RS10230	COG1329	Transcriptional regulator
PB2503_RS10235	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
PB2503_RS10240	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
PB2503_RS10270	COG1454	alcohol dehydrogenase
PB2503_RS10290	COG0588	phosphoglycerate mutase activity
PB2503_RS10315	COG2267	carboxylic ester hydrolase activity
PB2503_RS10320	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
PB2503_RS10320	COG0758	DNA mediated transformation
PB2503_RS10330	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
PB2503_RS10330	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
PB2503_RS10350	COG4771	TonB-dependent receptor
PB2503_RS10355	COG1064	alcohol dehydrogenase
PB2503_RS10365	COG2070	2-Nitropropane dioxygenase
PB2503_RS10370	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
PB2503_RS10375	COG1522	sequence-specific DNA binding
PB2503_RS10380	COG0248	Ppx GppA phosphatase
PB2503_RS10410	COG1028	Short-chain dehydrogenase reductase Sdr
PB2503_RS10420	COG0343	queuine tRNA-ribosyltransferase activity
PB2503_RS10480	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
PB2503_RS10485	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
PB2503_RS10490	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
PB2503_RS10495	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
PB2503_RS10500	COG0137	argininosuccinate synthase activity
PB2503_RS10505	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
PB2503_RS10510	COG0165	Argininosuccinate lyase
PB2503_RS10515	COG1538	Outer membrane efflux protein
PB2503_RS10520	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PB2503_RS10530	COG4771	TonB-dependent receptor
PB2503_RS10535	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
PB2503_RS10535	COG0321	lipoyl(octanoyl) transferase activity
PB2503_RS10540	COG0084	hydrolase, TatD family'
PB2503_RS10550	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
PB2503_RS10555	COG1686	Belongs to the peptidase S11 family
PB2503_RS10565	COG0538	isocitrate dehydrogenase activity
PB2503_RS10570	COG4152	abc transporter atp-binding protein
PB2503_RS10595	COG1385	rRNA (uridine-N3-)-methyltransferase activity
PB2503_RS10600	COG0629	single-stranded DNA binding
PB2503_RS10620	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
PB2503_RS10625	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
PB2503_RS10640	COG1304	FMN binding
PB2503_RS10650	COG0194	GDP metabolic process
PB2503_RS10655	COG1561	YicC-like family, N-terminal region
PB2503_RS10660	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
PB2503_RS10665	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PB2503_RS10670	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PB2503_RS10680	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
PB2503_RS10685	COG1132	(ABC) transporter
PB2503_RS10715	COG0297	glycogen (starch) synthase activity
PB2503_RS10735	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
PB2503_RS10750	COG0438	transferase activity, transferring glycosyl groups
PB2503_RS10755	COG0110	maltose O-acetyltransferase activity
PB2503_RS10775	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
PB2503_RS10815	COG4953	penicillin-binding protein 1C
PB2503_RS10830	COG1120	ATPase activity
PB2503_RS10835	COG4139	cobalamin transport
PB2503_RS10845	COG4206	TonB-dependent receptor
PB2503_RS10895	COG0505	Belongs to the CarA family
PB2503_RS10900	COG0004	ammonium transporteR
PB2503_RS10925	COG0625	glutathione transferase activity
PB2503_RS10930	COG0625	glutathione transferase activity
PB2503_RS10960	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
PB2503_RS10975	COG2072	flavoprotein involved in K transport
PB2503_RS10980	COG2351	hydroxyisourate hydrolase activity
PB2503_RS10995	COG2252	PERMEase
PB2503_RS11005	COG1529	Aldehyde oxidase and xanthine dehydrogenase
PB2503_RS11015	COG0402	S-adenosylhomocysteine deaminase activity
PB2503_RS11020	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
PB2503_RS11050	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PB2503_RS11055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PB2503_RS11060	COG1309	transcriptional regulator
PB2503_RS11085	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PB2503_RS11095	COG0315	cyclic pyranopterin monophosphate synthase activity
PB2503_RS11100	COG0521	Mo-molybdopterin cofactor biosynthetic process
PB2503_RS11105	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
PB2503_RS11125	COG1404	Belongs to the peptidase S8 family
PB2503_RS11155	COG1262	PFAM Formylglycine-generating sulfatase enzyme
PB2503_RS11195	COG1028	Short-chain dehydrogenase reductase Sdr
PB2503_RS11220	COG2239	Acts as a magnesium transporter
PB2503_RS11235	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
PB2503_RS11245	COG1007	ATP synthesis coupled electron transport
PB2503_RS11260	COG0713	ATP synthesis coupled electron transport
PB2503_RS11270	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
PB2503_RS11275	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
PB2503_RS11315	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
PB2503_RS11320	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
PB2503_RS11325	COG2264	protein methyltransferase activity
PB2503_RS11335	COG0544	peptidyl-prolyl cis-trans isomerase activity
PB2503_RS11345	COG0463	Glycosyl transferase, family 2
PB2503_RS11370	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
PB2503_RS11375	COG1923	regulation of RNA biosynthetic process
PB2503_RS11385	COG0569	domain protein
PB2503_RS11390	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
PB2503_RS11405	COG1278	Cold shock
PB2503_RS11410	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
PB2503_RS11425	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
PB2503_RS11430	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PB2503_RS11435	COG0741	lytic transglycosylase activity
PB2503_RS11455	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
PB2503_RS11465	COG0148	phosphopyruvate hydratase activity
PB2503_RS11470	COG0333	Belongs to the bacterial ribosomal protein bL32 family
PB2503_RS11480	COG0504	CTP synthase activity
PB2503_RS11530	COG1024	Enoyl-CoA hydratase
PB2503_RS11540	COG1028	Short-chain dehydrogenase reductase Sdr
PB2503_RS11550	COG0720	synthase
PB2503_RS11635	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PB2503_RS11650	COG2205	protein histidine kinase activity
PB2503_RS11670	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
PB2503_RS11720	COG2132	Multicopper oxidase
PB2503_RS11740	COG2217	Heavy metal translocating P-type atpase
PB2503_RS11765	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PB2503_RS11770	COG1937	Protein conserved in bacteria
PB2503_RS11790	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PB2503_RS11810	COG1742	UPF0060 membrane protein
PB2503_RS11815	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PB2503_RS11865	COG2963	transposase activity
PB2503_RS11960	COG2963	transposase activity
PB2503_RS11995	COG4962	Type ii secretion system protein e
PB2503_RS12000	COG3838	Conjugal transfer protein Trbc
PB2503_RS12010	COG3451	type IV secretory pathway VirB4
PB2503_RS12020	COG3846	protein secretion by the type IV secretion system
PB2503_RS12035	COG2948	multi-organism process
PB2503_RS12045	COG5489	Protein of unknown function (DUF736)
PB2503_RS12110	COG0517	IMP dehydrogenase activity
PB2503_RS12110	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
PB2503_RS12125	COG0745	RESPONSE REGULATOR receiver
PB2503_RS12135	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
PB2503_RS12165	COG0156	8-amino-7-oxononanoate synthase activity
PB2503_RS12200	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
PB2503_RS12225	COG0527	aspartate kinase activity
PB2503_RS12230	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
PB2503_RS12235	COG0658	competence protein
PB2503_RS12235	COG2333	competence protein COMEC
PB2503_RS12245	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PB2503_RS12250	COG0372	Belongs to the citrate synthase family
PB2503_RS12255	COG1012	belongs to the aldehyde dehydrogenase family
PB2503_RS12265	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
PB2503_RS12275	COG1612	heme a metabolic process
PB2503_RS12290	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
PB2503_RS12315	COG3264	Mechanosensitive ion channel
PB2503_RS12315	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
PB2503_RS12335	COG0151	Belongs to the GarS family
PB2503_RS12340	COG0259	pyridoxamine-phosphate oxidase activity
PB2503_RS12345	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
PB2503_RS12350	COG5507	3-demethylubiquinone-9 3-methyltransferase
PB2503_RS12380	COG0494	nUDIX hydrolase
PB2503_RS12390	COG0653	protein targeting
PB2503_RS12400	COG1136	(ABC) transporter
PB2503_RS12410	COG1408	metallophosphoesterase
PB2503_RS12415	COG0475	glutathione-regulated potassium exporter activity
PB2503_RS12415	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
PB2503_RS12420	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
PB2503_RS12430	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
PB2503_RS12435	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
PB2503_RS12450	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PB2503_RS12455	COG0318	PFAM AMP-dependent synthetase and ligase
PB2503_RS12460	COG0617	tRNA 3'-terminal CCA addition
PB2503_RS12465	COG0494	nUDIX hydrolase
PB2503_RS12475	COG0616	signal peptide processing
PB2503_RS12480	COG0714	Associated with various cellular activities
PB2503_RS12510	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
PB2503_RS12515	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
PB2503_RS12525	COG0729	surface antigen
PB2503_RS12540	COG0367	asparagine synthase
PB2503_RS12545	COG0505	Belongs to the CarA family
PB2503_RS12560	COG0004	ammonium transporteR
PB2503_RS12565	COG0358	DNA primase activity
PB2503_RS12570	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
PB2503_RS12585	COG3023	N-Acetylmuramoyl-L-alanine amidase
PB2503_RS12595	COG1132	(ABC) transporter
PB2503_RS12605	COG1519	Transferase
PB2503_RS12610	COG1663	tetraacyldisaccharide 4'-kinase activity
PB2503_RS12635	COG0706	membrane insertase activity
PB2503_RS12640	COG0218	Necessary for normal cell division and for the maintenance of normal septation
PB2503_RS12650	COG0277	FAD linked oxidase domain protein
PB2503_RS12680	COG0149	triose-phosphate isomerase activity
PB2503_RS12690	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
PB2503_RS12720	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
PB2503_RS12725	COG0134	indole-3-glycerol-phosphate synthase activity
PB2503_RS12730	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
PB2503_RS12740	COG3046	protein related to deoxyribodipyrimidine photolyase
PB2503_RS12775	COG2086	electron transfer activity
PB2503_RS12785	COG1546	Belongs to the CinA family
PB2503_RS12785	COG1058	Belongs to the CinA family
PB2503_RS12790	COG0649	NAD binding
PB2503_RS12800	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PB2503_RS12815	COG2205	protein histidine kinase activity
PB2503_RS12815	COG0784	Response regulator, receiver
PB2503_RS12815	COG5002	protein histidine kinase activity
PB2503_RS12820	COG0784	Response regulator, receiver
PB2503_RS12825	COG2205	protein histidine kinase activity
PB2503_RS12845	COG3850	Histidine kinase
PB2503_RS12845	COG3437	response regulator, receiver
PB2503_RS12845	COG4999	Histidine kinase
PB2503_RS12845	COG2205	protein histidine kinase activity
PB2503_RS12855	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PB2503_RS12860	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
PB2503_RS12870	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
PB2503_RS12875	COG1294	oxidase, subunit
PB2503_RS12880	COG1271	oxidase subunit
PB2503_RS12890	COG1294	oxidase, subunit
PB2503_RS12900	COG3047	cAMP biosynthetic process
PB2503_RS12905	COG4988	ABC transporter
PB2503_RS12910	COG4988	ABC transporter
PB2503_RS12915	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PB2503_RS12920	COG0745	RESPONSE REGULATOR receiver
PB2503_RS12950	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
PB2503_RS12955	COG3002	Belongs to the UPF0753 family
PB2503_RS12960	COG0175	sulfate reduction
PB2503_RS12970	COG3128	pkhd-type hydroxylase
PB2503_RS12975	COG1840	ABC-type Fe3 transport system, periplasmic component
PB2503_RS12980	COG3842	ATPase activity
PB2503_RS13000	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
PB2503_RS13000	COG0392	lysyltransferase activity
PB2503_RS13010	COG0531	amino acid
PB2503_RS13015	COG1116	anion transmembrane transporter activity
PB2503_RS13015	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PB2503_RS13030	COG0243	molybdopterin cofactor binding
PB2503_RS13040	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PB2503_RS13045	COG0746	molybdenum cofactor guanylyltransferase activity
PB2503_RS13050	COG0303	'Molybdopterin
PB2503_RS13065	COG2223	nitrite transmembrane transporter activity
PB2503_RS13070	COG0521	Mo-molybdopterin cofactor biosynthetic process
PB2503_RS13075	COG0314	molybdopterin synthase activity
PB2503_RS13085	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
PB2503_RS13100	COG1629	transport
PB2503_RS13100	COG4774	siderophore transport
PB2503_RS13110	COG4771	TonB-dependent receptor
PB2503_RS13120	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
PB2503_RS13125	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PB2503_RS13130	COG4558	Periplasmic binding protein
PB2503_RS13145	COG1131	(ABC) transporter
PB2503_RS13220	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PB2503_RS13225	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PB2503_RS13240	COG1937	Protein conserved in bacteria
PB2503_RS13245	COG2132	Multicopper oxidase
PB2503_RS13265	COG2217	Heavy metal translocating P-type atpase
PB2503_RS13300	COG0300	oxidoreductase activity
PB2503_RS13305	COG3387	PFAM Glycoside hydrolase 15-related
PB2503_RS13345	COG2814	Major facilitator Superfamily
PB2503_RS13365	COG0508	dehydrogenase complex catalyzes the overall conversion of
PB2503_RS13385	COG5642	Protein of unknown function (DUF2384)
PB2503_RS13425	COG2205	protein histidine kinase activity
PB2503_RS13460	COG0789	Transcriptional regulator
PB2503_RS13490	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
PB2503_RS13500	COG1230	cation diffusion facilitator family transporter
PB2503_RS13505	COG2226	methyltransferase
PB2503_RS13520	COG0671	phosphoesterase, PA-phosphatase related
PB2503_RS13590	COG1876	peptidase activity
PB2503_RS13595	COG0668	transmembrane transport
PB2503_RS13615	COG1196	nuclear chromosome segregation
PB2503_RS13615	COG0741	lytic transglycosylase activity
PB2503_RS13615	COG0739	heme binding
PB2503_RS13620	COG3772	lysozyme
PB2503_RS13635	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PB2503_RS13720	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
PB2503_RS13725	COG1006	Multisubunit Na H antiporter MnhC subunit
PB2503_RS13755	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
PB2503_RS13805	COG1214	PFAM Peptidase M22, glycoprotease
PB2503_RS13825	COG0799	negative regulation of ribosome biogenesis
PB2503_RS13875	COG0596	Alpha beta hydrolase
PB2503_RS13880	COG0628	permease
PB2503_RS13890	COG0545	Peptidyl-prolyl cis-trans isomerase
PB2503_RS13940	COG2267	carboxylic ester hydrolase activity
PB2503_RS13960	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
PB2503_RS13975	COG2205	protein histidine kinase activity
PB2503_RS13975	COG2202	Pas domain
PB2503_RS14000	COG0840	transmembrane signaling receptor activity
PB2503_RS14005	COG0489	protein tyrosine kinase activity
PB2503_RS14025	COG0745	RESPONSE REGULATOR receiver
PB2503_RS14040	COG2001	Belongs to the MraZ family
PB2503_RS14050	COG0110	maltose O-acetyltransferase activity
PB2503_RS14080	COG0438	transferase activity, transferring glycosyl groups
PB2503_RS14095	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
PB2503_RS14120	COG0438	transferase activity, transferring glycosyl groups
PB2503_RS14135	COG1752	Esterase of the alpha-beta hydrolase superfamily
PB2503_RS14180	COG5002	protein histidine kinase activity