locus-tag class description H0H18_RS00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) H0H18_RS00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) H0H18_RS00015 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) H0H18_RS00020 ENOG4105DVA methyltransferase H0H18_RS00025 ENOG4107RYR Transcriptional regulator, Crp Fnr family H0H18_RS00030 ENOG4105YP7 UPF0270 protein H0H18_RS00035 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) H0H18_RS00040 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) H0H18_RS00045 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase H0H18_RS00050 ENOG4105W5Q DNA repair protein (RadC H0H18_RS00055 ENOG4105KDC 50s ribosomal protein l28 H0H18_RS00060 ENOG4105W0E 50S ribosomal protein L33 H0H18_RS00065 ENOG4105S10 periplasmic binding protein H0H18_RS00070 ENOG4105EHG Permease protein H0H18_RS00075 ENOG4108W0P ABC transporter H0H18_RS00080 ENOG4108VJC ABC transporter, periplasmic molybdate-binding protein H0H18_RS00085 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) H0H18_RS00095 ENOG4107J0A lipopolysaccharide biosynthetic process H0H18_RS00100 ENOG4105VFB Binds the 23S rRNA (By similarity) H0H18_RS00110 ENOG4107S6X Glycosyl transferase, family 2 H0H18_RS00115 ENOG4107S6X Glycosyl transferase, family 2 H0H18_RS00120 ENOG4105X1N Glycosyl transferase family 8 H0H18_RS00135 ENOG4105C25 Primosomal protein n' H0H18_RS00140 ENOG41063M6 Cell Division Protein H0H18_RS00145 ENOG4105Y7M Transcriptional regulator, TetR family H0H18_RS00150 ENOG410624X efflux transporter, rnd family, mfp subunit H0H18_RS00160 ENOG4105BZS acriflavin resistance protein H0H18_RS00170 ENOG4105K89 arsenate reductase H0H18_RS00185 ENOG4105CH7 arginosuccinase H0H18_RS00190 ENOG4105CAS nag kinase H0H18_RS00195 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase H0H18_RS00200 ENOG4105CWC Acetylornithine deacetylase H0H18_RS00205 ENOG4108ST3 glycosyltransferase H0H18_RS00230 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) H0H18_RS00240 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) H0H18_RS00245 ENOG4105RT1 May be involved in cell division (By similarity) H0H18_RS00250 ENOG4105C1J atp-dependent rna helicase H0H18_RS00255 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase H0H18_RS00260 ENOG4108VEN abc transporter atp-binding protein H0H18_RS00270 ENOG4107XNE ABC transporter, periplasmic molybdate-binding protein H0H18_RS00275 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) H0H18_RS00290 ENOG4105CFC Transporter H0H18_RS00295 ENOG4108IJ0 Aspartate ammonia-lyase H0H18_RS00300 ENOG4105C38 Glycyl-tRNA synthetase beta subunit H0H18_RS00310 ENOG4108RXX maleylacetoacetate isomerase H0H18_RS00315 ENOG41063VX Inherit from COG: glutaredoxin-related protein H0H18_RS00320 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit H0H18_RS00330 ENOG4108IPT Naphthoate synthase H0H18_RS00340 ENOG4105DNI Converts SHCHC to OSB (By similarity) H0H18_RS00345 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) H0H18_RS00350 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein H0H18_RS00355 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase H0H18_RS00360 ENOG4105RG0 Membrane H0H18_RS00365 ENOG4108IA2 Sodium pantothenate symporter H0H18_RS00370 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) H0H18_RS00375 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) H0H18_RS00380 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) H0H18_RS00385 ENOG4108ETH Formylglycinamide ribotide synthetase H0H18_RS00390 ENOG4105ESI atpase involved in dna repair H0H18_RS00395 ENOG4105ZRN H0H18_RS00400 ENOG4106DNP H0H18_RS00405 ENOG4105UGU tonB-dependent Receptor H0H18_RS00415 ENOG4105EHG Permease protein H0H18_RS00420 ENOG4107R4I Periplasmic binding protein H0H18_RS00435 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain H0H18_RS00450 ENOG4105D0C transport protein H0H18_RS00455 ENOG4105KZW UPF0381 protein H0H18_RS00460 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation H0H18_RS00465 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) H0H18_RS00470 ENOG4105IRT Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity) H0H18_RS00475 ENOG4105EE5 Membrane protein terC H0H18_RS00480 ENOG4105C2M dna polymerase I H0H18_RS00485 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family H0H18_RS00490 ENOG4105E61 Mannitol repressor protein H0H18_RS00495 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase H0H18_RS00500 ENOG4105CTS PTS system mannitol-specific H0H18_RS00510 ENOG4105C4R Atp-dependent dna helicase H0H18_RS00535 ENOG4107VXZ Hydrolase H0H18_RS00545 ENOG4105W39 Membrane H0H18_RS00550 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) H0H18_RS00555 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR H0H18_RS00560 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen H0H18_RS00565 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) H0H18_RS00570 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) H0H18_RS00575 ENOG4108P11 EamA-like transporter family H0H18_RS00580 ENOG4105D9M gamma-glutamylcysteine synthetase H0H18_RS00585 ENOG4105TRI Hydrolase H0H18_RS00590 ENOG4105C9A Phoh family H0H18_RS00595 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) H0H18_RS00615 ENOG4105DIJ Phosphoethanolamine transferase H0H18_RS00620 ENOG4108JA2 transcriptioN-repair coupling factor H0H18_RS00625 ENOG4108HWV )-transporter H0H18_RS00630 ENOG4105C2J ABC transporter H0H18_RS00635 ENOG4105EMA Periplasmic binding protein LacI transcriptional regulator H0H18_RS00640 ENOG41060NJ transcriptional regulator H0H18_RS00645 ENOG4105F0Z galactose-1-phosphate uridylyltransferase H0H18_RS00650 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) H0H18_RS00655 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) H0H18_RS00660 ENOG4108JU5 Magnesium and cobalt efflux protein H0H18_RS00665 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) H0H18_RS00670 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) H0H18_RS00675 ENOG4105C1B dTDP-glucose 4-6-dehydratase H0H18_RS00680 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) H0H18_RS00685 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) H0H18_RS00690 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP H0H18_RS00695 ENOG4105GPY SprT protein H0H18_RS00705 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) H0H18_RS00710 ENOG4105KUZ arsenate reductase H0H18_RS00715 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) H0H18_RS00725 ENOG41087AY ADP-Ribose pyrophosphatase H0H18_RS00730 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) H0H18_RS00740 ENOG4105KJF protein tyrosine phosphatase H0H18_RS00745 ENOG4105DAY polysaccharide export protein H0H18_RS00755 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase H0H18_RS00770 ENOG4105D3Q Sugar transferase H0H18_RS00780 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase H0H18_RS00790 ENOG4105C5E polysaccharide biosynthesis protein H0H18_RS00810 ENOG4107QQG Dehydrogenase H0H18_RS00815 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family H0H18_RS00820 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) H0H18_RS00825 ENOG4108478 ec 3.2.1.18 H0H18_RS00835 ENOG4107ZJM MltA-interacting protein MipA H0H18_RS00840 ENOG4105DJY efflux transporter, rnd family, mfp subunit H0H18_RS00845 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) H0H18_RS00865 ENOG4105C28 cystathionine H0H18_RS00870 ENOG4105K63 Thioredoxin H0H18_RS00875 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) H0H18_RS00880 ENOG4105EI2 Pseudouridine synthase H0H18_RS00885 ENOG4105C03 ribonuclease H0H18_RS00900 ENOG4105D3Y Na H antiporter H0H18_RS00905 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) H0H18_RS00910 ENOG4108UYE Lactoylglutathione lyase H0H18_RS00920 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) H0H18_RS00925 ENOG4108WWS isoprenylcysteine carboxyl methyltransferase H0H18_RS00930 ENOG4105C9M aspartyl-trna synthetase H0H18_RS00940 ENOG4108TIT dATP pyrophosphohydrolase H0H18_RS00945 ENOG4105CDY transcriptional regulatory protein H0H18_RS00955 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) H0H18_RS00960 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) H0H18_RS00965 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) H0H18_RS00975 ENOG4105C4M (Ubiquinol oxidase) subunit I H0H18_RS00980 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii H0H18_RS00995 ENOG4107YD3 Thioesterase H0H18_RS01000 ENOG4105E02 MotA TolQ exbB proton channel H0H18_RS01015 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) H0H18_RS01020 ENOG4105KCK Peptidoglycan-associated lipoprotein H0H18_RS01055 ENOG4105DSY exodeoxyribonuclease V, gamma H0H18_RS01060 ENOG4105KEG ribosomal-protein-alanine acetyltransferase H0H18_RS01065 ENOG4108WPU DNA polymerase III subunit psi H0H18_RS01070 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) H0H18_RS01075 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) H0H18_RS01080 ENOG4107RCV ABC transporter, permease H0H18_RS01085 ENOG4105C4Y ABC transporter H0H18_RS01090 ENOG4105C4Y ABC transporter H0H18_RS01095 ENOG4105C4Y ABC transporter H0H18_RS01100 ENOG4105DBI uridine monophosphokinase H0H18_RS01105 ENOG4105DHP deoxycytidine triphosphate deaminase H0H18_RS01115 ENOG4105F27 Major Facilitator H0H18_RS01185 ENOG4105DFP Integrase H0H18_RS01195 ENOG4105CHH sulfate transporter H0H18_RS01200 ENOG4108UHU Aldolase H0H18_RS01210 ENOG4105C8N cysteinyl-tRNA synthetase H0H18_RS01215 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) H0H18_RS01220 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) H0H18_RS01225 ENOG4105EYA deoxyribonuclease H0H18_RS01235 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) H0H18_RS01240 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase H0H18_RS01245 ENOG4105CA0 peroxidase H0H18_RS01250 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis H0H18_RS01255 ENOG4105CFH Aspartokinase H0H18_RS01260 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) H0H18_RS01265 ENOG4105EN6 Membrane H0H18_RS01275 ENOG4105CEE C4-dicarboxylate transporter H0H18_RS01290 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 H0H18_RS01295 ENOG4105DFU Cell wall formation (By similarity) H0H18_RS01305 ENOG4105CA3 membrane-bound lytic murein transglycosylase H0H18_RS01310 ENOG4105CUZ uba thif-type nad fad binding protein H0H18_RS01315 ENOG4105NXV High-affinity zinc uptake system protein H0H18_RS01320 ENOG4108IQE Amp-dependent synthetase and ligase H0H18_RS01330 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase H0H18_RS01335 ENOG4105E0X reductase H0H18_RS01340 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) H0H18_RS01345 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) H0H18_RS01350 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) H0H18_RS01355 ENOG4105CB5 ATP-dependent DNA helicase recG H0H18_RS01360 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) H0H18_RS01365 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) H0H18_RS01410 ENOG4105PYN Pyridoxamine 5-phosphate oxidase-related H0H18_RS01420 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) H0H18_RS01425 ENOG4105D1F ATP-binding protein H0H18_RS01430 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) H0H18_RS01435 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) H0H18_RS01450 ENOG4105M6W Crispr-associated protein, Csy3 family H0H18_RS01460 ENOG4107SV5 CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) H0H18_RS01470 ENOG4105BZU Histidine kinase H0H18_RS01480 ENOG4105ECY inositol monophosphatase H0H18_RS01485 ENOG4105CVS RNA methyltransferase TrmH family, group 1 H0H18_RS01490 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family H0H18_RS01495 ENOG4105C3J Cysteine desulfurase H0H18_RS01500 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins H0H18_RS01505 ENOG4108Z4V iron-sulfur cluster assembly H0H18_RS01510 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) H0H18_RS01515 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB H0H18_RS01520 ENOG4108ZIT Ferredoxin, 2FE-2S H0H18_RS01525 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase H0H18_RS01530 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) H0H18_RS01535 ENOG4107SC1 transglycosylase H0H18_RS01540 ENOG4105K9H YciI-like protein H0H18_RS01545 ENOG4105NAU thioesterase Superfamily protein H0H18_RS01550 ENOG4107835 probably involved in intracellular septation (By similarity) H0H18_RS01560 ENOG4105EIF outer membrane protein W H0H18_RS01565 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) H0H18_RS01570 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) H0H18_RS01575 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ H0H18_RS01580 ENOG4107R6U sodium dicarboxylate symporter H0H18_RS01590 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) H0H18_RS01595 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) H0H18_RS01600 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) H0H18_RS01605 ENOG4105CK7 Sodium proline symporter H0H18_RS01610 ENOG4105C03 ribonuclease H0H18_RS01615 ENOG4105D1U peptidase U62 modulator of DNA gyrase H0H18_RS01620 ENOG4105C8Y Acetylornithine aminotransferase H0H18_RS01625 ENOG4105WPN DNA integration recombination invertion protein H0H18_RS01630 ENOG4105EAH synthase H0H18_RS01635 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) H0H18_RS01640 ENOG4105K46 50S ribosomal protein l27 H0H18_RS01645 ENOG4105QYV Membrane H0H18_RS01650 ENOG4105QYV Membrane H0H18_RS01655 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control H0H18_RS01660 ENOG41090R7 Ferric uptake H0H18_RS01665 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) H0H18_RS01670 ENOG4105NNH LexA regulated protein H0H18_RS01675 ENOG4105EV9 Alpha Beta Hydrolase H0H18_RS01680 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) H0H18_RS01685 ENOG4105CEY Amp-dependent synthetase and ligase H0H18_RS01690 ENOG4105EGS Mechanosensitive ion channel H0H18_RS01695 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase H0H18_RS01700 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) H0H18_RS01705 ENOG4105EJ9 Membrane H0H18_RS01710 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase H0H18_RS01715 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) H0H18_RS01720 ENOG4107QMP dna polymerase iii subunits gamma and tau H0H18_RS01725 ENOG4105EEQ Na H antiporter H0H18_RS01730 ENOG4105M4H endoribonuclease L-psp H0H18_RS01735 ENOG4108VTV Inherit from NOG: Membrane H0H18_RS01745 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) H0H18_RS01750 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) H0H18_RS01755 ENOG4105D3D Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine (By similarity) H0H18_RS01770 ENOG4106R49 Methyltransferase H0H18_RS01775 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) H0H18_RS01780 ENOG4105DP9 ABC transporter H0H18_RS01785 ENOG4106SMU thiamine transporter membrane protein H0H18_RS01790 ENOG4107T0D ABC, transporter H0H18_RS01795 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) H0H18_RS01800 ENOG4105C8J )-transporter H0H18_RS01805 ENOG4105CSM endonuclease III H0H18_RS01810 ENOG4105DZB Electron transport complex H0H18_RS01815 ENOG4108UQQ Electron transport complex H0H18_RS01820 ENOG4105D6A Electron transport complex H0H18_RS01825 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) H0H18_RS01830 ENOG4108R3D Electron transport complex H0H18_RS01835 ENOG4105DGN Electron transport complex H0H18_RS01850 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) H0H18_RS01855 ENOG4108DG9 Smr protein MutS2 H0H18_RS01860 ENOG4105EM2 membrane H0H18_RS01865 ENOG410901E Membrane H0H18_RS01870 ENOG4108Z5K methylglyoxal synthase H0H18_RS01875 ENOG41068P6 UPF0319 protein H0H18_RS01880 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 H0H18_RS01885 ENOG4105CC5 ABC transporter H0H18_RS01890 ENOG4105CC5 ABC transporter H0H18_RS01895 ENOG4105DIK (ABC) transporter H0H18_RS01905 ENOG4108Z0T Part of a sulfur-relay system (By similarity) H0H18_RS01910 ENOG4108MN8 Membrane H0H18_RS01920 ENOG4105F46 Necessary for formate dehydrogenase activity (By similarity) H0H18_RS01925 ENOG4108MG3 formate dehydrogenase H0H18_RS01930 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein H0H18_RS01940 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) H0H18_RS01945 ENOG4105C4R Atp-dependent dna helicase H0H18_RS01950 ENOG4105CDU Replicative dna helicase H0H18_RS01955 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) H0H18_RS01960 ENOG4105K64 Glycosyl transferase, family 2 H0H18_RS01970 ENOG4107QP8 phosphohexose isomerase H0H18_RS01990 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) H0H18_RS01995 ENOG4105DZ2 Transcriptional regulator H0H18_RS02000 ENOG4106CC8 Bacterial inner membrane protein H0H18_RS02005 ENOG4105C5H ABC transporter H0H18_RS02010 ENOG41065CD Exported protein H0H18_RS02015 ENOG4105D7X high-affinity nickel-transporter H0H18_RS02030 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) H0H18_RS02040 ENOG4105BZU Histidine kinase H0H18_RS02045 ENOG4105CK6 Two component transcriptional regulator (Winged helix family H0H18_RS02050 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) H0H18_RS02055 ENOG4105E2Z phosphate ABC transporter (Permease H0H18_RS02060 ENOG4105C8U phosphate abc transporter H0H18_RS02065 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) H0H18_RS02070 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) H0H18_RS02075 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) H0H18_RS02080 ENOG4105EEI dihydropteroate synthase H0H18_RS02085 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) H0H18_RS02090 ENOG4108BY2 phosphohistidine phosphatase H0H18_RS02100 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) H0H18_RS02105 ENOG4107M7T YcgL domain H0H18_RS02125 ENOG4108I0Y (ABC) transporter H0H18_RS02135 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) H0H18_RS02150 ENOG4107SJW iron permease, FTR1 H0H18_RS02155 ENOG4105EQ6 Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids (By similarity) H0H18_RS02160 ENOG4105EZR dyp-type peroxidase family protein H0H18_RS02165 ENOG4105BZ4 penicillin-binding protein H0H18_RS02170 ENOG4108ZIG UPF0231 protein H0H18_RS02175 ENOG4108YX9 iron--sulfur cluster insertion protein erpA H0H18_RS02180 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) H0H18_RS02185 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) H0H18_RS02195 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase H0H18_RS02200 ENOG4105ESV Glycosyl transferase, family 4 H0H18_RS02250 ENOG4105DWU Membrane H0H18_RS02255 ENOG4105CPB ATP-dependent endonuclease of the OLD family H0H18_RS02260 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) H0H18_RS02265 ENOG4105D0M Protease HtpX homolog H0H18_RS02270 ENOG4108BPE -transporting atpase H0H18_RS02275 ENOG4105DA5 (ABC) transporter H0H18_RS02280 ENOG4105E3A (ABC) transporter H0H18_RS02285 ENOG4105H1G trap transporter solute receptor taxi family H0H18_RS02300 ENOG4105EWT decarboxylase family H0H18_RS02305 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) H0H18_RS02310 ENOG4105EXF Zn-ribbon-containing, possibly nucleic-acid-binding protein H0H18_RS02315 ENOG4105WP7 tRNA pseudouridine synthase C H0H18_RS02320 ENOG4105DR9 pseudouridine synthase H0H18_RS02325 ENOG4105X5C UPF0181 protein H0H18_RS02335 ENOG4108R9Q Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity) H0H18_RS02340 ENOG4105DAN ATP-dependent protease H0H18_RS02345 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) H0H18_RS02350 ENOG4108Z66 YbaK ebsC protein H0H18_RS02355 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) H0H18_RS02365 ENOG4105D5K Hemolysin activator protein H0H18_RS02370 ENOG4105CKT filamentous hemagglutinin H0H18_RS02370 ENOG4105CKT filamentous hemagglutinin H0H18_RS02475 ENOG41080C8 DUF218 domain H0H18_RS02480 ENOG4108MY6 biosynthesis protein H0H18_RS02485 ENOG4105P7J Transfers sialic acid from the substrate CMP-sialic acid donor to the terminal beta-D-galactosyl-1,4-acetyl-beta-D- glucosamine on the lacto-N-neotetraose branch of the lipooligosaccharide H0H18_RS02490 ENOG41068D6 Glycosyltransferase H0H18_RS02500 ENOG4108RJ9 Glycosyl transferase, family 2 H0H18_RS02505 ENOG4108RYC glycosyltransferase H0H18_RS02510 ENOG4105CVE Lytic murein transglycosylase H0H18_RS02515 ENOG4105C7N Xanthine uracil vitamin C permease H0H18_RS02520 ENOG41090EX DsrE family H0H18_RS02525 ENOG4107QKA exodeoxyribonuclease V beta H0H18_RS02530 ENOG4107QYX exodeoxyribonuclease v alpha H0H18_RS02535 ENOG4105E9S glutaredoxin 2 H0H18_RS02540 ENOG4105KWI UPF0339 protein H0H18_RS02545 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) H0H18_RS02550 ENOG4108UJD 30S ribosomal protein S9 H0H18_RS02555 ENOG4107MKT Stringent starvation protein a H0H18_RS02560 ENOG4105KB2 stringent starvation protein b H0H18_RS02565 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase H0H18_RS02570 ENOG4105C2X Arabinose 5-phosphate isomerase H0H18_RS02580 ENOG4106N3A copper homeostasis protein cutc H0H18_RS02585 ENOG4105ENJ RND efflux system, outer membrane lipoprotein H0H18_RS02590 ENOG4105CX6 glutaminyL-tRNA synthetase H0H18_RS02595 ENOG4105BZG amino acid carrier protein H0H18_RS02605 ENOG4108QD6 H0H18_RS02610 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) H0H18_RS02615 ENOG4105CTB Polyprenyl synthetase H0H18_RS02620 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) H0H18_RS02625 ENOG4107QY8 reductase H0H18_RS02630 ENOG4105CUW cytochrome C-TYPE protein H0H18_RS02635 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) H0H18_RS02640 ENOG4105XW2 UPF0263 protein H0H18_RS02645 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) H0H18_RS02650 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) H0H18_RS02655 ENOG4108ZZ3 UPF0260 protein H0H18_RS02660 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) H0H18_RS02665 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) H0H18_RS02670 ENOG4108ESZ Glycogen debranching enzyme H0H18_RS02675 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) H0H18_RS02680 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) H0H18_RS02685 ENOG4108IUN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) H0H18_RS02690 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) H0H18_RS02695 ENOG4105ETE Transcriptional regulator (LacI family H0H18_RS02700 ENOG4105ECP epimerase H0H18_RS02705 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) H0H18_RS02710 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) H0H18_RS02715 ENOG4105C75 arginyL-tRNA synthetase H0H18_RS02720 ENOG4105NBI YecM protein H0H18_RS02730 ENOG4108XTF Outer Membrane Lipoprotein H0H18_RS02735 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) H0H18_RS02740 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) H0H18_RS02745 ENOG41063JG Transcriptional regulator H0H18_RS02750 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase H0H18_RS02755 ENOG4105C5I Dehydrogenase H0H18_RS02760 ENOG4105D60 lipoprotein releasing system transmembrane protein H0H18_RS02765 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) H0H18_RS02770 ENOG4105D60 lipoprotein releasing system transmembrane protein H0H18_RS02775 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) H0H18_RS02780 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin H0H18_RS02785 ENOG4105DZC cytosine deaminase H0H18_RS02790 ENOG4105CM2 brancheD-chain amino acid aminotransferase H0H18_RS02795 ENOG4105ETT transcriptional Regulator, LysR family H0H18_RS02800 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) H0H18_RS02805 ENOG4105ED9 Protein of unknown function (DUF455) H0H18_RS02810 ENOG4105C29 acyl-CoA thioesterase H0H18_RS02820 ENOG4108JJ8 (ABC) transporter H0H18_RS02825 ENOG4108JJ9 ABC, transporter H0H18_RS02830 ENOG4105C3M thioredoxin reductase H0H18_RS02835 ENOG4107QR8 Thioredoxin H0H18_RS02840 ENOG41077A9 carbonic anhydrase H0H18_RS02845 ENOG4105X58 receptor H0H18_RS02850 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) H0H18_RS02855 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) H0H18_RS02860 ENOG4105EMU Dehydrogenase H0H18_RS02865 ENOG4105DK0 Indole-3-glycerol phosphate synthase H0H18_RS02870 ENOG4108I0Q anthranilate phosphoribosyltransferase H0H18_RS02880 ENOG4105DDQ anthranilate synthase H0H18_RS02885 ENOG4105CRQ synthase (Component I) H0H18_RS02890 ENOG4105ERU peptidase H0H18_RS02905 ENOG4105CK7 Sodium proline symporter H0H18_RS02925 ENOG4105DEF Extracellular solute-binding protein, family 5 H0H18_RS02930 ENOG4105C22 threonyL-tRNA synthetase H0H18_RS02940 ENOG4107RUZ Sss sodium solute transporter superfamily H0H18_RS02955 ENOG4105C4X radical SAM domain protein H0H18_RS02960 ENOG4105DSB aldose 1-epimerase H0H18_RS02965 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) H0H18_RS02970 ENOG41082NX 50s ribosomal protein l35 H0H18_RS02975 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) H0H18_RS02990 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) H0H18_RS02995 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) H0H18_RS03000 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) H0H18_RS03005 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) H0H18_RS03010 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) H0H18_RS03015 ENOG4108TZV Membrane H0H18_RS03020 ENOG4105CJB Exodeoxyribonuclease I H0H18_RS03025 ENOG4105NE1 Conserved Protein H0H18_RS03030 ENOG41076KX Protein of unknown function (DUF1469) H0H18_RS03040 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) H0H18_RS03045 ENOG4105DB7 PHP domain protein H0H18_RS03050 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) H0H18_RS03055 ENOG4105CD8 aminopeptidase N H0H18_RS03060 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) H0H18_RS03065 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit H0H18_RS03070 ENOG4105CGF Aromatic amino acid aminotransferase H0H18_RS03075 ENOG4108ZAF Molybdopterin H0H18_RS03080 ENOG4105M00 molybdopterin converting factor, subunit 1 H0H18_RS03085 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) H0H18_RS03090 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) H0H18_RS03095 ENOG4105CHW UPF0052 protein H0H18_RS03100 ENOG4108QBX (LipO)protein H0H18_RS03105 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) H0H18_RS03110 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) H0H18_RS03120 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) H0H18_RS03130 ENOG4108W1A pseudouridine synthase H0H18_RS03135 ENOG4105CVJ phosphoglycerate mutase H0H18_RS03140 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase H0H18_RS03145 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) H0H18_RS03150 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) H0H18_RS03160 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) H0H18_RS03165 ENOG4108VD1 dedA family H0H18_RS03170 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) H0H18_RS03175 ENOG4105DAG ROK family H0H18_RS03180 ENOG4105C5S asparaginyl-tRNA synthetase H0H18_RS03185 ENOG4108JQB penicillin-binding protein 1C H0H18_RS03190 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) H0H18_RS03195 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) H0H18_RS03200 ENOG41082RQ UPF0102 protein H0H18_RS03205 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) H0H18_RS03210 ENOG4105W4M Transport-associated protein H0H18_RS03215 ENOG4108R6K riboflavin synthase, subunit alpha H0H18_RS03220 ENOG4107QI1 Mate efflux family protein H0H18_RS03225 ENOG4105D9R oxidoreductase H0H18_RS03230 ENOG4105CA9 Pyruvate kinase H0H18_RS03280 ENOG4105CDU Replicative dna helicase H0H18_RS03350 ENOG4105WXW Antirepressor H0H18_RS03385 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) H0H18_RS03390 ENOG4105DN3 alpha-2-macroglobulin domain protein H0H18_RS03395 ENOG4107R11 Transcriptional regulator H0H18_RS03400 ENOG4105FE9 pseudouridine synthase H0H18_RS03405 ENOG4107RTD sua5 ycio yrdc ywlc family protein H0H18_RS03415 ENOG4105EHE chorismate mutase- prephenate dehydrogenase H0H18_RS03420 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) H0H18_RS03425 ENOG41090A1 ferritin H0H18_RS03430 ENOG41090A1 ferritin H0H18_RS03435 ENOG4105DS0 Transcriptional regulator, Crp Fnr family H0H18_RS03440 ENOG4105Q9Y Universal stress protein H0H18_RS03450 ENOG4105D07 Signal peptide peptidase, SppA H0H18_RS03455 ENOG41069NU Nitroreductase H0H18_RS03460 ENOG4105XTM Inherit from NOG: Mn2 dependent serine threonine protein kinase H0H18_RS03470 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) H0H18_RS03475 ENOG4105EYK Phosphatidylglycerophosphatase B H0H18_RS03480 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) H0H18_RS03485 ENOG4107TSG Extracellular solute-binding protein, family 5 H0H18_RS03490 ENOG4105WD1 Membrane H0H18_RS03495 ENOG4105DGW oligopeptidase A H0H18_RS03500 ENOG4105K3M )-transporter H0H18_RS03520 ENOG4105E2R ROK family H0H18_RS03525 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) H0H18_RS03530 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) H0H18_RS03535 ENOG4105D1A Methyltransferase H0H18_RS03540 ENOG4105DDY UPF0142 protein ycaO H0H18_RS03545 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III H0H18_RS03555 ENOG4105GXY Family of unknown function (DUF695) H0H18_RS03560 ENOG4105CGK Exodeoxyribonuclease III H0H18_RS03565 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) H0H18_RS03570 ENOG4105EUJ GTP cyclohydrolase i H0H18_RS03575 ENOG4105CVM Molybdenum cofactor synthesis domain protein H0H18_RS03580 ENOG4105D06 uba thif-type nad fad binding protein H0H18_RS03585 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase H0H18_RS03590 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase H0H18_RS03595 ENOG4105E96 Colicin v production protein H0H18_RS03600 ENOG4105PQ6 UPF0208 membrane protein H0H18_RS03605 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) H0H18_RS03610 ENOG4108DNC Involved in acetate metabolism (By similarity) H0H18_RS03615 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) H0H18_RS03620 ENOG4105CEY Amp-dependent synthetase and ligase H0H18_RS03625 ENOG4105R8X Outer membrane lipoprotein Slp H0H18_RS03630 ENOG41072GX Peptidase M22 Glycoprotease H0H18_RS03635 ENOG4105DVT helicase H0H18_RS03640 ENOG4105DSB aldose 1-epimerase H0H18_RS03650 ENOG4105HBR Rna-binding protein H0H18_RS03660 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) H0H18_RS03665 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase H0H18_RS03670 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) H0H18_RS03675 ENOG4105C8J )-transporter H0H18_RS03685 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) H0H18_RS03690 ENOG4105XPH Ferredoxin H0H18_RS03695 ENOG4105DB1 molybdopterin oxidoreductase H0H18_RS03700 ENOG4106WHD Tetrathionate reductase H0H18_RS03705 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein H0H18_RS03710 ENOG4106AFQ Histidine kinase H0H18_RS03715 ENOG4108ZXC Two component transcriptional regulator, luxr family H0H18_RS03720 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) H0H18_RS03725 ENOG4105CCF Lysine exporter protein (Lyse ygga) H0H18_RS03730 ENOG4108ZAI phosphatidylglycerophosphatase a H0H18_RS03735 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) H0H18_RS03740 ENOG4107YIM Involved in the transcription termination process (By similarity) H0H18_RS03745 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) H0H18_RS03750 ENOG4105E0U tyrosine-specific transport protein H0H18_RS03760 ENOG4105C0H protease H0H18_RS03765 ENOG4106J39 exported protein H0H18_RS03770 ENOG4105CFG Acts as a chaperone (By similarity) H0H18_RS03790 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) H0H18_RS03800 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) H0H18_RS03805 ENOG4105E0C molybdate abc transporter H0H18_RS03810 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein H0H18_RS03820 ENOG4105F4R Transcriptional regulator mode H0H18_RS03825 ENOG4105DK2 UPF0207 protein H0H18_RS03830 ENOG4105C0H protease H0H18_RS03835 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) H0H18_RS03840 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) H0H18_RS03850 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) H0H18_RS03855 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) H0H18_RS03860 ENOG4105PW4 Sugar fermentation stimulation protein homolog H0H18_RS03865 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) H0H18_RS03870 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) H0H18_RS03875 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) H0H18_RS03885 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) H0H18_RS03890 ENOG4105CHV Transcription elongation factor NusA H0H18_RS03895 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) H0H18_RS03905 ENOG4105DW5 Transcriptional regulator H0H18_RS03935 ENOG4105VUH addiction module killer protein H0H18_RS03965 ENOG4105CQ7 ATP-dependent helicase H0H18_RS03970 ENOG4105M08 Membrane H0H18_RS03980 ENOG41084CK capsule polysaccharide H0H18_RS04005 ENOG4105K64 Glycosyl transferase, family 2 H0H18_RS04020 ENOG4108RDB capsule polysaccharide export inner-membrane protein H0H18_RS04030 ENOG4105M2J Glutaredoxin H0H18_RS04035 ENOG4105HA9 of methanol dehydrogenase type H0H18_RS04045 ENOG4108V0P LemA family H0H18_RS04055 ENOG4105CQB FAD linked oxidase domain protein H0H18_RS04060 ENOG4105KA0 thioesterase Superfamily protein H0H18_RS04065 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) H0H18_RS04070 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) H0H18_RS04075 ENOG4105DIQ Transcriptional regulator H0H18_RS04080 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family H0H18_RS04085 ENOG4105C6Z Gluconate H0H18_RS04090 ENOG4105C28 cystathionine H0H18_RS04095 ENOG4105D3R alkyl hydroperoxide reductase H0H18_RS04105 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) H0H18_RS04110 ENOG4105CFV Tetratricopeptide repeat protein H0H18_RS04115 ENOG4105Q4A inner membrane protein yciS H0H18_RS04120 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) H0H18_RS04125 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) H0H18_RS04130 ENOG4105CAT Cytidine monophosphate kinase H0H18_RS04135 ENOG4105PE1 Receptor H0H18_RS04140 ENOG4107RAN Peptidase, M16 H0H18_RS04150 ENOG4105CXN decarboxylase H0H18_RS04155 ENOG4105D5Q Arginine ornithine antiporter H0H18_RS04160 ENOG4105DBV ornithine carbamoyltransferase H0H18_RS04165 ENOG4108MJ5 VirK protein H0H18_RS04170 ENOG4105E0U tyrosine-specific transport protein H0H18_RS04175 ENOG4105C0F tryptophanase EC 4.1.99.1 H0H18_RS04180 ENOG4105CDH Citrulline--aspartate ligase H0H18_RS04185 ENOG4107SRH Nad-dependent epimerase dehydratase H0H18_RS04190 ENOG4105C8V SAICAR synthetase H0H18_RS04195 ENOG4108I6E Sulfatase H0H18_RS04200 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) H0H18_RS04205 ENOG4108RMU ferritin dps family protein H0H18_RS04210 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) H0H18_RS04220 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) H0H18_RS04230 ENOG4105MYG DNA polymerase iii, chi subunit H0H18_RS04235 ENOG4105C9Q fumarate hydratase class II H0H18_RS04240 ENOG4105RHG H0H18_RS04245 ENOG4105D0Y UPF0227 protein H0H18_RS04250 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) H0H18_RS04255 ENOG41090BQ Glutaredoxin H0H18_RS04260 ENOG4107QZM n-acetylglutamate synthase H0H18_RS04265 ENOG4105EIP mannose-6-phosphate isomerase H0H18_RS04270 ENOG4108NK4 UPF0266 membrane protein H0H18_RS04280 ENOG4105F3R pts system mannose fructose sorbose family iid H0H18_RS04285 ENOG4105ETZ PTS System H0H18_RS04290 ENOG4105DAS pts system H0H18_RS04295 ENOG4107RGD Major Facilitator superfamily H0H18_RS04300 ENOG41090HJ UPF0265 protein H0H18_RS04305 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) H0H18_RS04310 ENOG4105CIH Imidazole acetol-phosphate transaminase H0H18_RS04315 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase H0H18_RS04320 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) H0H18_RS04325 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) H0H18_RS04415 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase H0H18_RS04420 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) H0H18_RS04425 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) H0H18_RS04430 ENOG41085JB UPF0434 protein H0H18_RS04435 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) H0H18_RS04440 ENOG4105BZ1 (ABC) transporter H0H18_RS04445 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 H0H18_RS04450 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters H0H18_RS04455 ENOG4105DJ0 Poly(A) Polymerase H0H18_RS04460 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase H0H18_RS04465 ENOG4105DWV Homoserine O-trans-acetylase H0H18_RS04470 ENOG4107GZ4 SanA protein H0H18_RS04475 ENOG4107B7Y DNA-binding transcriptional regulator FruR H0H18_RS04480 ENOG4108ZP8 Acetolactate synthase small subunit H0H18_RS04485 ENOG4105C7K acetolactate synthase H0H18_RS04490 ENOG4107S6Z Na H antiporter H0H18_RS04495 ENOG4108SAU DNA-binding protein H-ns H0H18_RS04500 ENOG4105CIY formyltetrahydrofolate deformylase H0H18_RS04505 ENOG4105CE4 GlcNAc 6-P deacetylase H0H18_RS04510 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) H0H18_RS04515 ENOG4105CI1 PTS System H0H18_RS04520 ENOG4105C5H ABC transporter H0H18_RS04525 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein H0H18_RS04530 ENOG41067MG lrgb family H0H18_RS04535 ENOG4105VAW lrga family H0H18_RS04540 ENOG4105KK6 nuclease H0H18_RS04545 ENOG4105C9B Cysteine desulfurase H0H18_RS04550 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) H0H18_RS04555 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) H0H18_RS04560 ENOG4105D1S lipid A biosynthesis H0H18_RS04565 ENOG4107XHZ cytoplasmic chaperone TorD family protein H0H18_RS04570 ENOG4105DYS nad(p)h dehydrogenase (quinone) H0H18_RS04580 ENOG4107QX8 SPFH domain, Band 7 family protein H0H18_RS04585 ENOG4105DKW ABC transporter H0H18_RS04600 ENOG4107QN2 dihydrolipoyl dehydrogenase H0H18_RS04605 ENOG4107QSN dihydrolipoamide acetyltransferase H0H18_RS04610 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) H0H18_RS04615 ENOG4105C5Y PTS System H0H18_RS04620 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) H0H18_RS04625 ENOG4105KZ7 phosphocarrier protein hpr H0H18_RS04630 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) H0H18_RS04635 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) H0H18_RS04650 ENOG4105K8N protein family UPF0079, ATPase H0H18_RS04655 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase H0H18_RS04660 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) H0H18_RS04665 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) H0H18_RS04670 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) H0H18_RS04675 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) H0H18_RS04680 ENOG4108JU8 Transcriptional regulator H0H18_RS04685 ENOG4106K28 UPF0283 membrane protein H0H18_RS04690 ENOG4105CM6 amino acid regulated cytosolic protein H0H18_RS04695 ENOG4108EVY peptide transport periplasmic protein H0H18_RS04705 ENOG4108EU3 peptide transport system, permease H0H18_RS04710 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein H0H18_RS04720 ENOG4105CHR reductase H0H18_RS04745 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase H0H18_RS04750 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) H0H18_RS04755 ENOG4108UMI ABC transporter, permease H0H18_RS04760 ENOG4105D01 (LipO)protein H0H18_RS04770 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) H0H18_RS04775 ENOG4105K70 DNA-binding protein H0H18_RS04780 ENOG4105R2J Conserved Protein H0H18_RS04785 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) H0H18_RS04790 ENOG4105E09 nadh pyrophosphatase H0H18_RS04795 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) H0H18_RS04800 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) H0H18_RS04805 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) H0H18_RS04810 ENOG4108VZM 50s ribosomal protein L10 H0H18_RS04815 ENOG4105C6Z Gluconate H0H18_RS04820 ENOG4105BZW Glycerate kinase H0H18_RS04825 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) H0H18_RS04830 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) H0H18_RS04835 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) H0H18_RS04840 ENOG4105PM1 preprotein translocase subunit SecE H0H18_RS04845 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) H0H18_RS04850 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) H0H18_RS04855 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) H0H18_RS04860 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) H0H18_RS04870 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) H0H18_RS04875 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) H0H18_RS04880 ENOG4105WWK YheO domain protein H0H18_RS04885 ENOG4108V1T peptidylprolyl cis-trans isomerase H0H18_RS04890 ENOG41069P5 Protein slyX homolog H0H18_RS04895 ENOG4105EHV domain protein H0H18_RS04900 ENOG4105C5Q Transcriptional regulator H0H18_RS04905 ENOG4105EJ2 Transcriptional regulator H0H18_RS04910 ENOG4107FB0 transcriptional regulator DeoR family H0H18_RS04915 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) H0H18_RS04920 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) H0H18_RS04925 ENOG4105CXY transporter H0H18_RS04930 ENOG4108KX4 response regulator H0H18_RS04935 ENOG4105BZU Histidine kinase H0H18_RS04940 ENOG4105CXY transporter H0H18_RS04945 ENOG4105PGM cation diffusion facilitator family transporter H0H18_RS04950 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) H0H18_RS04960 ENOG4105CJ2 (LipO)protein H0H18_RS04965 ENOG4108EGU NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) H0H18_RS04970 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) H0H18_RS04975 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) H0H18_RS04980 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) H0H18_RS04985 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) H0H18_RS04990 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) H0H18_RS04995 ENOG4105CNN ABC, transporter H0H18_RS05000 ENOG4105C2J ABC transporter H0H18_RS05005 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator H0H18_RS05010 ENOG4105M85 Bola protein H0H18_RS05015 ENOG4105IEY (LipO)protein H0H18_RS05035 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division H0H18_RS05040 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) H0H18_RS05045 ENOG4105CEN a g-specific adenine glycosylase H0H18_RS05050 ENOG4105CPW cytochrome b561 H0H18_RS05055 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) H0H18_RS05060 ENOG41090ED Protein with unknown function (DUF469) H0H18_RS05065 ENOG4107QUT magnesium and cobalt transport protein CorA H0H18_RS05070 ENOG4108VIA integral membrane protein H0H18_RS05080 ENOG4108HYK gCN5-related N-acetyltransferase H0H18_RS05085 ENOG4105CP7 Triose-phosphate isomerase H0H18_RS05090 ENOG4108BSC Methyltransferase H0H18_RS05095 ENOG4105E0A ABC, transporter H0H18_RS05100 ENOG4105EHG Permease protein H0H18_RS05105 ENOG4105S10 periplasmic binding protein H0H18_RS05110 ENOG4106WTF Glycosyl transferase, family 2 H0H18_RS05115 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase H0H18_RS05120 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) H0H18_RS05125 ENOG4108W7E Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position (By similarity) H0H18_RS05130 ENOG4105DKP glycosyl transferase, family 9 H0H18_RS05135 ENOG4105BZ1 (ABC) transporter H0H18_RS05145 ENOG4105GAV receptor H0H18_RS05155 ENOG4105CH2 amidohydrolase H0H18_RS05165 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) H0H18_RS05170 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) H0H18_RS05175 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) H0H18_RS05180 ENOG4105K5M 30s ribosomal protein S16 H0H18_RS05185 ENOG4105M5K heptosyltransferase H0H18_RS05190 ENOG4108VW9 Membrane H0H18_RS05195 ENOG4105D9N nucleoside H0H18_RS05200 ENOG4105D3A purine nucleoside phosphorylase DeoD-type H0H18_RS05205 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) H0H18_RS05210 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase H0H18_RS05215 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) H0H18_RS05220 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) H0H18_RS05225 ENOG4108M6U Universal stress protein A H0H18_RS05230 ENOG4105DXN mazG family H0H18_RS05235 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase H0H18_RS05240 ENOG4105EMY transcriptional regulator H0H18_RS05250 ENOG4105DTR rard protein H0H18_RS05265 ENOG41061GT Aldolase H0H18_RS05285 ENOG4105C2J ABC transporter H0H18_RS05290 ENOG4105DKT Transcriptional regulator H0H18_RS05295 ENOG4107RYS Autoinducer-2 (AI-2) kinase H0H18_RS05300 ENOG4105E2X shikimate dehydrogenase H0H18_RS05305 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) H0H18_RS05310 ENOG4108WI1 Dna topoisomerase H0H18_RS05315 ENOG4108Z03 MAF-like protein H0H18_RS05320 ENOG4105CGY Dna recombination protein H0H18_RS05325 ENOG4108YI8 ABC transporter H0H18_RS05330 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component H0H18_RS05335 ENOG4105ETU transcriptional activator (TenA H0H18_RS05340 ENOG4107Z6I Thiamine biosynthesis protein H0H18_RS05345 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase H0H18_RS05350 ENOG4105DWF phosphomethylpyrimidine kinase H0H18_RS05355 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) H0H18_RS05360 ENOG4105CSH Transporter H0H18_RS05365 ENOG4108TEB UPF0114 protein H0H18_RS05370 ENOG4105J4Q Transcriptional regulator H0H18_RS05375 ENOG4105DG4 malate L-lactate dehydrogenase H0H18_RS05380 ENOG4108R66 Conserved Protein H0H18_RS05385 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter H0H18_RS05390 ENOG4105CG6 trap dicarboxylate transporter dctm subunit H0H18_RS05395 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit H0H18_RS05400 ENOG4105C2J ABC transporter H0H18_RS05420 ENOG4105CMG Carbohydrate kinase H0H18_RS05430 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase H0H18_RS05435 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase H0H18_RS05440 ENOG410667J hydrolase H0H18_RS05445 ENOG4105CV1 Transketolase (EC 2.2.1.1) H0H18_RS05450 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) H0H18_RS05455 ENOG4108EUD Lysophospholipase H0H18_RS05460 ENOG4107Z6W Protein CrcB homolog H0H18_RS05465 ENOG4105DQF Hydrolase H0H18_RS05475 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit H0H18_RS05485 ENOG4105C01 Dihydroxy-acid dehydratase H0H18_RS05490 ENOG4105C7B Threonine dehydratase H0H18_RS05505 ENOG4105C31 Tryptophanyl-tRNA synthetase H0H18_RS05510 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) H0H18_RS05515 ENOG4105DJV ribulose-phosphate 3-epimerase H0H18_RS05525 ENOG4105K5B UPF0225 protein H0H18_RS05530 ENOG4107S2Z UPF0761 membrane protein H0H18_RS05535 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) H0H18_RS05540 ENOG4108K5P (LipO)protein H0H18_RS05550 ENOG4108UM1 dedA family H0H18_RS05555 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) H0H18_RS05565 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) H0H18_RS05570 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) H0H18_RS05575 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) H0H18_RS05580 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) H0H18_RS05585 ENOG4108HMX isocitrate dehydrogenase (NADP) H0H18_RS05590 ENOG4108R99 pseudouridine synthase H0H18_RS05605 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) H0H18_RS05610 ENOG4108R3E Dna-3-methyladenine glycosylase i H0H18_RS05615 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) H0H18_RS05620 ENOG4105C79 DNA protecting protein DprA H0H18_RS05625 ENOG4105CUW cytochrome C-TYPE protein H0H18_RS05630 ENOG4105IYZ Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) H0H18_RS05635 ENOG4105GXZ Ferredoxin-type protein NapH H0H18_RS05640 ENOG4108BGM Quinol dehydrogenase periplasmic component H0H18_RS05645 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) H0H18_RS05660 ENOG4105BZU Histidine kinase H0H18_RS05665 ENOG4107XNU peptidase H0H18_RS05670 ENOG4105D4A Cell wall formation (By similarity) H0H18_RS05680 ENOG4108NKP c4-dicarboxylate transporter malic acid transport protein H0H18_RS05685 ENOG4107RZC phospholipase d H0H18_RS05690 ENOG4105C8P )-transporter H0H18_RS05695 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) H0H18_RS05705 ENOG4105C5H ABC transporter H0H18_RS05710 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein H0H18_RS05725 ENOG4105H1G trap transporter solute receptor taxi family H0H18_RS05730 ENOG4108PSC Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator (By similarity) H0H18_RS05735 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate H0H18_RS05740 ENOG4105C5Y PTS System H0H18_RS05745 ENOG4105CU9 asparagine synthetase A H0H18_RS05750 ENOG4108VVK transcriptional Regulator, AsnC H0H18_RS05755 ENOG4108I5U Uridine phosphorylase H0H18_RS05760 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) H0H18_RS05770 ENOG4105KJF protein tyrosine phosphatase H0H18_RS05775 ENOG4105Z2P Protein of unknown function (DUF465) H0H18_RS05780 ENOG4108YZY peptidylprolyl cis-trans isomerase H0H18_RS05790 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) H0H18_RS05795 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) H0H18_RS05800 ENOG4105C1A potassium transporter peripheral membrane H0H18_RS05805 ENOG4105K64 Glycosyl transferase, family 2 H0H18_RS05810 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B H0H18_RS05815 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) H0H18_RS05820 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) H0H18_RS05850 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) H0H18_RS05855 ENOG4105MJ2 Competence protein H0H18_RS05890 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase H0H18_RS05895 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase H0H18_RS05900 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) H0H18_RS05905 ENOG4105VEJ Heat shock protein H0H18_RS05910 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 H0H18_RS05915 ENOG4107RK2 ADP-ribose diphosphatase NudE H0H18_RS05920 ENOG41070ZG H0H18_RS05925 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase H0H18_RS05930 ENOG4105DZR Type I site-specific deoxyribonuclease H0H18_RS05940 ENOG4105EKX Restriction modification system DNA (Specificity H0H18_RS05945 ENOG4105CVR type I restriction-modification system H0H18_RS05950 ENOG4105C26 Dehydrogenase H0H18_RS05965 ENOG4105C2C drug resistance transporter, Bcr CflA H0H18_RS05975 ENOG4107THI 3,4-dihydroxyphenylacetate 2,3-dioxygenase H0H18_RS05980 ENOG4105C26 Dehydrogenase H0H18_RS05995 ENOG4105CG6 trap dicarboxylate transporter dctm subunit H0H18_RS06015 ENOG4105EFA 4-hydroxyphenylacetate H0H18_RS06020 ENOG4107UWN reductase H0H18_RS06025 ENOG4105CRP Part of the ABC transporter FtsEX involved in H0H18_RS06030 ENOG4105CAK Cell division ATP-binding protein ftsE H0H18_RS06035 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) H0H18_RS06045 ENOG4106H78 methyltransferase H0H18_RS06060 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) H0H18_RS06065 ENOG4108MJ5 VirK protein H0H18_RS06070 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) H0H18_RS06075 ENOG4105C0P Mg chelatase subunit ChlI H0H18_RS06085 ENOG41079J1 H0H18_RS06090 ENOG4105PXI polysaccharide deacetylase H0H18_RS06095 ENOG41063SB peptidase H0H18_RS06100 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) H0H18_RS06105 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain H0H18_RS06115 ENOG4105JAB phenazine biosynthesis protein, phzf family H0H18_RS06120 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain H0H18_RS06125 ENOG410903C (LipO)protein H0H18_RS06130 ENOG4105XWI UPF0304 protein H0H18_RS06165 ENOG4108RR8 protoporphyrinogen oxidase H0H18_RS06170 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) H0H18_RS06175 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein H0H18_RS06180 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) H0H18_RS06185 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) H0H18_RS06190 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) H0H18_RS06195 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) H0H18_RS06200 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) H0H18_RS06205 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) H0H18_RS06210 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) H0H18_RS06215 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) H0H18_RS06220 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) H0H18_RS06230 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) H0H18_RS06235 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) H0H18_RS06240 ENOG4105QTB Flavodoxin H0H18_RS06245 ENOG4105N4M Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) H0H18_RS06250 ENOG4105CBT Fructose-1,6-bisphosphatase H0H18_RS06255 ENOG41080HT Transcriptional regulator, arsr family H0H18_RS06260 ENOG4108V62 Rhodanese domain protein H0H18_RS06270 ENOG4106IEQ H0H18_RS06280 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) H0H18_RS06290 ENOG4108JJ9 ABC, transporter H0H18_RS06295 ENOG4105BZ1 (ABC) transporter H0H18_RS06305 ENOG4105KVH Transcriptional regulator H0H18_RS06310 ENOG4108V1U phospholipid-binding protein H0H18_RS06315 ENOG4108QD1 Membrane H0H18_RS06330 ENOG4105KME endoribonuclease L-psp H0H18_RS06340 ENOG4105CRQ synthase (Component I) H0H18_RS06345 ENOG4105DDQ anthranilate synthase H0H18_RS06355 ENOG4105HMI Membrane H0H18_RS06360 ENOG4107TXD phosphoglycerate transport system transcriptional regulatory protein pgta H0H18_RS06370 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC H0H18_RS06380 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) H0H18_RS06390 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) H0H18_RS06395 ENOG4105C0A alcohol dehydrogenase H0H18_RS06400 ENOG4106HK8 GPR1 FUN34 yaaH family protein H0H18_RS06410 ENOG4108RRZ Transcription elongation factor GreB H0H18_RS06420 ENOG4105BZM domain protein H0H18_RS06435 ENOG41082EK Restriction modification system DNA (Specificity H0H18_RS06450 ENOG41060QA UPF0267 protein H0H18_RS06455 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) H0H18_RS06460 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) H0H18_RS06465 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase H0H18_RS06470 ENOG4105CXY transporter H0H18_RS06475 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A H0H18_RS06480 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B H0H18_RS06485 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) H0H18_RS06490 ENOG4105E98 transcriptional regulator DeoR family H0H18_RS06495 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) H0H18_RS06510 ENOG4105D7A ATP-binding protein H0H18_RS06515 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter H0H18_RS06520 ENOG4107YZP Rhodanese domain protein H0H18_RS06525 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) H0H18_RS06530 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase H0H18_RS06535 ENOG4105D7W serine acetyltransferase H0H18_RS06540 ENOG4105F9E Shikimate 5-dehydrogenase H0H18_RS06545 ENOG4105UGU tonB-dependent Receptor H0H18_RS06550 ENOG4105C9U ATP-dependent DNA helicase RecQ H0H18_RS06555 ENOG4105HDD phospholipase H0H18_RS06560 ENOG4105XQ6 frataxin-like protein H0H18_RS06565 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) H0H18_RS06570 ENOG4105D9Q decarboxylase (Beta subunit) H0H18_RS06575 ENOG4107QSA Oxaloacetate decarboxylase H0H18_RS06580 ENOG4106AFN Lyase and sodium transporter (By similarity) H0H18_RS06590 ENOG4105C0F tryptophanase EC 4.1.99.1 H0H18_RS06595 ENOG4105CIC tryptophan-specific transport protein H0H18_RS06600 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) H0H18_RS06620 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) H0H18_RS06625 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) H0H18_RS06630 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) H0H18_RS06635 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity H0H18_RS06640 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) H0H18_RS06645 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) H0H18_RS06650 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) H0H18_RS06655 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) H0H18_RS06660 ENOG41083MP 50s ribosomal protein l29 H0H18_RS06665 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal H0H18_RS06675 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) H0H18_RS06680 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits H0H18_RS06685 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) H0H18_RS06690 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) H0H18_RS06695 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) H0H18_RS06700 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) H0H18_RS06705 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) H0H18_RS06715 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) H0H18_RS06720 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) H0H18_RS06725 ENOG41067V7 50S ribosomal protein L36 H0H18_RS06730 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits H0H18_RS06740 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) H0H18_RS06745 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) H0H18_RS06750 ENOG4108ZT0 50S ribosomal protein l17 H0H18_RS06755 ENOG4108VVQ metallophosphoesterase H0H18_RS06760 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase H0H18_RS06765 ENOG4105W0Z cytoplasmic protein H0H18_RS06770 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) H0H18_RS06775 ENOG4107RUE extracellular solute-binding protein family 1 H0H18_RS06780 ENOG4105CJP fad dependent oxidoreductase H0H18_RS06785 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) H0H18_RS06795 ENOG4105CQZ Histidine kinase H0H18_RS06800 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) H0H18_RS06805 ENOG4108RS6 transposase H0H18_RS06810 ENOG4105C2I pirin domain protein H0H18_RS06815 ENOG4105C2J ABC transporter H0H18_RS06820 ENOG4105CNN ABC, transporter H0H18_RS06825 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator H0H18_RS06835 ENOG4105DKQ ROK family H0H18_RS06855 ENOG4105T16 Transcriptional regulator (AraC family) H0H18_RS06860 ENOG4108HWW ABC transporter H0H18_RS06865 ENOG4105C2J ABC transporter H0H18_RS06870 ENOG4105DFW ABC transporter H0H18_RS06875 ENOG4105DFD Na H antiporter H0H18_RS06885 ENOG4105C93 Xylose Isomerase H0H18_RS06890 ENOG4105CMG Carbohydrate kinase H0H18_RS06895 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) H0H18_RS06900 ENOG4108UHU Aldolase H0H18_RS06905 ENOG4107SS6 2-dehydro-3-deoxygluconokinase H0H18_RS06915 ENOG4105DMW Dehydrogenase reductase H0H18_RS06920 ENOG4105CG6 trap dicarboxylate transporter dctm subunit H0H18_RS06925 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter H0H18_RS06930 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit H0H18_RS06935 ENOG4107YCY Transcriptional regulator H0H18_RS06940 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) H0H18_RS06945 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) H0H18_RS06950 ENOG4105CIN aminoacyl-histidine dipeptidase H0H18_RS06955 ENOG4105MVE transcriptional regulator H0H18_RS06960 ENOG4105ZXK Dehydrogenase H0H18_RS06965 ENOG4105G63 Type III effector Hrp-dependent H0H18_RS06970 ENOG4105FB2 class II Aldolase H0H18_RS06975 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) H0H18_RS06985 ENOG4105V1F Fermentation respiration switch protein H0H18_RS06990 ENOG4105EXW epimerase dehydratase H0H18_RS06995 ENOG4105C6Z Gluconate H0H18_RS07005 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) H0H18_RS07030 ENOG4105CS9 pantothenic acid kinase H0H18_RS07035 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) H0H18_RS07040 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) H0H18_RS07045 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) H0H18_RS07050 ENOG4105CI1 PTS System H0H18_RS07055 ENOG4105KT7 mgtC SapB transporter H0H18_RS07060 ENOG4107QY8 reductase H0H18_RS07065 ENOG4105QAX Iron-sulfur H0H18_RS07070 ENOG4107KGK dmso reductase anchor subunit H0H18_RS07075 ENOG4108NEM leader-binding protein dmsD H0H18_RS07080 ENOG4105N1P Ferredoxin-type protein H0H18_RS07085 ENOG4105EM7 Selenocysteine-specific translation elongation factor H0H18_RS07090 ENOG4105DU0 nucleoside hydrolase H0H18_RS07095 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) H0H18_RS07105 ENOG4105C0R drug resistance transporter emrb qaca subfamily H0H18_RS07110 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b H0H18_RS07115 ENOG4105WMJ Positive regulator of sigma E, RseC MucC H0H18_RS07120 ENOG4105VQK sigma E regulatory protein, MucB RseB H0H18_RS07125 ENOG41069PW sigma-e factor negative regulatory protein H0H18_RS07130 ENOG4105EMN RNA polymerase sigma factor H0H18_RS07135 ENOG4105Y75 tpr repeat protein H0H18_RS07140 ENOG4105C94 Transporter H0H18_RS07150 ENOG4105CUW cytochrome C-TYPE protein H0H18_RS07155 ENOG4108J2R molybdopterin oxidoreductase H0H18_RS07160 ENOG4109039 Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) H0H18_RS07165 ENOG4105DM4 PTS System H0H18_RS07170 ENOG4105DE4 1-phosphofructokinase H0H18_RS07175 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein H0H18_RS07185 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) H0H18_RS07195 ENOG4108Z33 Thiol disulfide Interchange Protein H0H18_RS07200 ENOG4108WFC UPF0438 protein yifE H0H18_RS07205 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) H0H18_RS07210 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) H0H18_RS07220 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) H0H18_RS07225 ENOG4105C9X ppx gppa phosphatase H0H18_RS07230 ENOG4105MA0 exported protein H0H18_RS07235 ENOG4105CFU surface antigen H0H18_RS07240 ENOG4105WH1 Two component transcriptional regulator luxr family H0H18_RS07245 ENOG4107T0K Adenylate cyclase H0H18_RS07250 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) H0H18_RS07260 ENOG4105ECF c-methyltransferase H0H18_RS07265 ENOG410601J HemY protein H0H18_RS07270 ENOG4105Y3E Modulates RecA activity (By similarity) H0H18_RS07275 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) H0H18_RS07315 ENOG4105E6M Sulphatase-modifying factor protein H0H18_RS07340 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) H0H18_RS07345 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) H0H18_RS07350 ENOG4108RCM Nitroreductase H0H18_RS07355 ENOG4105D4P Coproporphyrinogen iii oxidase H0H18_RS07360 ENOG4105XCT Protein of unknown function (DUF2489) H0H18_RS07365 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) H0H18_RS07370 ENOG4105D3G Pseudouridine synthase H0H18_RS07375 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) H0H18_RS07385 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) H0H18_RS07390 ENOG4105C1J atp-dependent rna helicase H0H18_RS07395 ENOG4105D16 lipopolysaccharide heptosyltransferase i H0H18_RS07400 ENOG4105XA0 heptosyltransferase ii H0H18_RS07410 ENOG4105C5Y PTS System H0H18_RS07415 ENOG4105WBN Transcriptional regulator (LacI family H0H18_RS07425 ENOG4105D7K pfkb domain protein H0H18_RS07430 ENOG41075W9 High frequency lysogenization protein HflD homolog H0H18_RS07435 ENOG4107QTF adenylosuccinate lyase H0H18_RS07440 ENOG4105DAA L-lactate H0H18_RS07445 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) H0H18_RS07450 ENOG4107QR9 Iron-sulfur cluster binding protein H0H18_RS07455 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) H0H18_RS07460 ENOG4105JIM Phosphatidylserine synthase H0H18_RS07465 ENOG4105EIB trna rrna methyltransferase H0H18_RS07470 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding H0H18_RS07475 ENOG41083KI ribonuclease, T2 H0H18_RS07480 ENOG4105BZA Phosphoglycerate kinase H0H18_RS07485 ENOG4105D2N Aldolase H0H18_RS07490 ENOG4105PF3 O-Antigen polymerase H0H18_RS07495 ENOG41080IJ Diacylglycerol kinase H0H18_RS07500 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) H0H18_RS07505 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) H0H18_RS07510 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) H0H18_RS07515 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) H0H18_RS07520 ENOG4108UJU UPF0301 protein H0H18_RS07525 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) H0H18_RS07530 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) H0H18_RS07535 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) H0H18_RS07545 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) H0H18_RS07550 ENOG4105DSJ YicC domain protein H0H18_RS07555 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) H0H18_RS07560 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) H0H18_RS07565 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) H0H18_RS07575 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) H0H18_RS07580 ENOG4105PAD Hydrolase H0H18_RS07590 ENOG4105E68 Sulfatase H0H18_RS07595 ENOG4105YDX UPF0352 protein H0H18_RS07600 ENOG4106V8H Nucleoid-associated protein H0H18_RS07605 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) H0H18_RS07610 ENOG4105E3W Two component transcriptional regulator (Winged helix family H0H18_RS07615 ENOG4105E0F Histidine kinase H0H18_RS07620 ENOG4105EX9 Membrane H0H18_RS07635 ENOG4105C59 p-type ATPase H0H18_RS07640 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) H0H18_RS07645 ENOG4107XM3 UPF0442 protein H0H18_RS07650 ENOG4105DWK Membrane H0H18_RS07655 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) H0H18_RS07665 ENOG4108V1T peptidylprolyl cis-trans isomerase H0H18_RS07670 ENOG4105DJ4 phosphatidylserine decarboxylase H0H18_RS07675 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) H0H18_RS07680 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) H0H18_RS07685 ENOG4105HSA Protein of unknown function (DUF452) H0H18_RS07690 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) H0H18_RS07695 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) H0H18_RS07705 ENOG4108JQ7 (ABC) transporter H0H18_RS07710 ENOG4105C3U ABC transporter H0H18_RS07715 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component H0H18_RS07720 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component H0H18_RS07725 ENOG4107QSI ABC, transporter H0H18_RS07730 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein H0H18_RS07735 ENOG4105VGS 50s ribosomal protein l32 H0H18_RS07740 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) H0H18_RS07745 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) H0H18_RS07750 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase H0H18_RS07755 ENOG4105CHR reductase H0H18_RS07760 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) H0H18_RS07765 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter H0H18_RS07775 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) H0H18_RS07780 ENOG4105C1J atp-dependent rna helicase H0H18_RS07785 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) H0H18_RS07790 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) H0H18_RS07795 ENOG4105CJN penicillin-binding protein H0H18_RS07800 ENOG4105CNI cell division protein FtsW H0H18_RS07805 ENOG4105K6T rare lipoprotein A H0H18_RS07810 ENOG4105DZ1 carboxypeptidase H0H18_RS07820 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) H0H18_RS07825 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) H0H18_RS07845 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) H0H18_RS07860 ENOG4108UUM single-stranded DNA-binding protein H0H18_RS07865 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) H0H18_RS07870 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) H0H18_RS07875 ENOG4105C2N RNA methyltransferase TrmH family group 3 H0H18_RS07880 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) H0H18_RS07885 ENOG4105DFF Rod shape-determining protein mreb H0H18_RS07890 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) H0H18_RS07900 ENOG4108ZPB UPF0306 protein H0H18_RS07905 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) H0H18_RS07910 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) H0H18_RS07915 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) H0H18_RS07920 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) H0H18_RS07925 ENOG410804X Transcriptional regulator H0H18_RS07930 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 H0H18_RS07935 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 H0H18_RS07940 ENOG4105J92 DNA-binding transcriptional activator GutM H0H18_RS07945 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase H0H18_RS07950 ENOG4105VI0 Pts system, glucitol sorbitol-specific H0H18_RS07955 ENOG4105DZY Pts system, glucitol sorbitol-specific H0H18_RS07960 ENOG410787A Pts system, glucitol sorbitol-specific H0H18_RS07965 ENOG4105CGZ zinc metallopeptidase H0H18_RS07970 ENOG4108WZM domain protein H0H18_RS07975 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation H0H18_RS07980 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) H0H18_RS07985 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) H0H18_RS07990 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) H0H18_RS07995 ENOG4105EIN peptidylprolyl cis-trans isomerase H0H18_RS08000 ENOG4105ENJ RND efflux system, outer membrane lipoprotein H0H18_RS08005 ENOG4105CMI transporter H0H18_RS08010 ENOG4105CJ1 ABC, transporter H0H18_RS08015 ENOG4105D0S secretion protein (HlyD H0H18_RS08020 ENOG4105CE9 30S ribosomal protein S2 H0H18_RS08025 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) H0H18_RS08030 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) H0H18_RS08035 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) H0H18_RS08040 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) H0H18_RS08045 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) H0H18_RS08050 ENOG4105KNE Phosphatidate cytidylyltransferase H0H18_RS08055 ENOG4105DZP Membrane-associated zinc metalloprotease H0H18_RS08060 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane H0H18_RS08070 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) H0H18_RS08075 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) H0H18_RS08080 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) H0H18_RS08085 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) H0H18_RS08090 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) H0H18_RS08095 ENOG4107QWE )-transporter H0H18_RS08100 ENOG4108UMZ Cdp-alcohol phosphatidyltransferase H0H18_RS08110 ENOG4108HPI phosphatidate Cytidylyltransferase H0H18_RS08115 ENOG4108RIR Molybdenum cofactor biosynthesis protein H0H18_RS08120 ENOG4108YZA Nitrogen regulatory protein pii H0H18_RS08125 ENOG4105DSF transport protein H0H18_RS08130 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs H0H18_RS08135 ENOG41090FY type IV pilus biogenesis stability protein PilW H0H18_RS08140 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) H0H18_RS08145 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) H0H18_RS08150 ENOG4105CUT histidyl-tRNA synthetase H0H18_RS08155 ENOG4105N21 Membrane H0H18_RS08165 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic H0H18_RS08170 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) H0H18_RS08175 ENOG4105C6K Malic enzyme H0H18_RS08180 ENOG4105I08 Pseudouridine synthase H0H18_RS08185 ENOG4105C2C drug resistance transporter, Bcr CflA H0H18_RS08190 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) H0H18_RS08195 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) H0H18_RS08200 ENOG41060IM Heme exporter protein H0H18_RS08205 ENOG4105X3C heme exporter protein H0H18_RS08210 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) H0H18_RS08215 ENOG4105DA4 cytochrome c-type biogenesis protein H0H18_RS08220 ENOG4107QX9 Thiol disulfide interChange protein H0H18_RS08225 ENOG4108M1T Cytochrome c-type biogenesis protein H0H18_RS08230 ENOG4108M1T Cytochrome c-type biogenesis protein H0H18_RS08235 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase H0H18_RS08250 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) H0H18_RS08255 ENOG4105C2W permease H0H18_RS08260 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) H0H18_RS08265 ENOG4108V3E phosphoribosylglycinamide formyltransferase H0H18_RS08270 ENOG4105CXB phosphoribosylaminoimidazole synthetase H0H18_RS08280 ENOG4105EAU Plays a role in nitrite reduction (By similarity) H0H18_RS08285 ENOG4105JJ8 Cytochrome c nitrite reductase, pentaheme subunit H0H18_RS08290 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein H0H18_RS08295 ENOG4105DVI reductase, NrfD H0H18_RS08300 ENOG4105DA4 cytochrome c-type biogenesis protein H0H18_RS08305 ENOG4107QX9 Thiol disulfide interChange protein H0H18_RS08310 ENOG4108DMF Cytochrome C biogenesis protein H0H18_RS08315 ENOG4108DMF Cytochrome C biogenesis protein H0H18_RS08320 ENOG4105CBX hi0933 family H0H18_RS08325 ENOG4105CH6 catalase H0H18_RS08330 ENOG4105C0B DNA polymerase III (alpha subunit) H0H18_RS08335 ENOG4108XC3 NADH ubiquinone oxidoreductase H0H18_RS08340 ENOG4105EJQ L-serine dehydratase H0H18_RS08345 ENOG4105C44 Serine transporter H0H18_RS08350 ENOG4105E7A Glutamine amidotransferase H0H18_RS08365 ENOG4105CQ0 ABC transporter H0H18_RS08370 ENOG4105PYN Pyridoxamine 5-phosphate oxidase-related H0H18_RS08375 ENOG4105D82 Glutamate dehydrogenase H0H18_RS08380 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein H0H18_RS08385 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) H0H18_RS08395 ENOG41080I0 Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) H0H18_RS08400 ENOG4105DKR Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) H0H18_RS08405 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) H0H18_RS08410 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) H0H18_RS08425 ENOG4105CHM Aminotransferase H0H18_RS08430 ENOG4105E4F Isochorismate synthase H0H18_RS08435 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) H0H18_RS08440 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) H0H18_RS08455 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) H0H18_RS08460 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) H0H18_RS08465 ENOG4105C3F Signal peptidase i H0H18_RS08470 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) H0H18_RS08475 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) H0H18_RS08480 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) H0H18_RS08485 ENOG4105D1Q UPF0246 protein H0H18_RS08495 ENOG41076HS cation diffusion facilitator family transporter H0H18_RS08500 ENOG4105CTQ phosphohexokinase H0H18_RS08510 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) H0H18_RS08520 ENOG4105K59 histidine triad (HIT) protein H0H18_RS08525 ENOG4105TMB Formate nitrite transporter H0H18_RS08530 ENOG4105C6N Formate acetyltransferase H0H18_RS08540 ENOG4105F1A Pyruvate formate-lyase H0H18_RS08545 ENOG4108Z6B deaminase H0H18_RS08550 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) H0H18_RS08555 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) H0H18_RS08560 ENOG4105HF0 Membrane H0H18_RS08565 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) H0H18_RS08570 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase H0H18_RS08580 ENOG4107QHF type ii secretion system protein e H0H18_RS08585 ENOG4105D7Q type ii secretion system H0H18_RS08595 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) H0H18_RS08600 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) H0H18_RS08610 ENOG4105BZG amino acid carrier protein H0H18_RS08615 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA H0H18_RS08620 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) H0H18_RS08625 ENOG4105D8G Major Facilitator superfamily H0H18_RS08630 ENOG4105II7 pyrroline-5-carboxylate reductase H0H18_RS08635 ENOG4105DH7 May be involved in recombination (By similarity) H0H18_RS08645 ENOG4108UBT opacity-associated protein H0H18_RS08650 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein H0H18_RS08655 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) H0H18_RS08665 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) H0H18_RS08670 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase H0H18_RS08675 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) H0H18_RS08685 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) H0H18_RS08700 ENOG4107RZZ dna polymerase iii epsilon subunit H0H18_RS08705 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) H0H18_RS08730 ENOG4105DFA alanine racemase domain protein H0H18_RS08740 ENOG4105CFH Aspartokinase H0H18_RS08745 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) H0H18_RS08750 ENOG4105D98 threonine synthase H0H18_RS08755 ENOG4105W8Z 4'-phosphopantetheinyl transferase H0H18_RS08760 ENOG4107QJR hflk protein H0H18_RS08765 ENOG4105EPW hflc protein H0H18_RS08770 ENOG4105N42 UPF0307 protein H0H18_RS08775 ENOG4105CMS peptidase U62, modulator of DNA gyrase H0H18_RS08780 ENOG4108UGV hypoxanthine phosphoribosyltransferase H0H18_RS08785 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) H0H18_RS08790 ENOG4105E5Z arginine transporter ATP-binding subunit H0H18_RS08795 ENOG4106PMH Extracellular solute-binding protein family 3 H0H18_RS08800 ENOG4105GBT ABC transporter H0H18_RS08805 ENOG4105DMR ABC, transporter H0H18_RS08815 ENOG4105E0A ABC, transporter H0H18_RS08820 ENOG4108IHU transport system permease protein H0H18_RS08825 ENOG4105DQ5 transport system permease protein H0H18_RS08830 ENOG4108HUF Transporter H0H18_RS08840 ENOG4108V6E Cell division protein mraZ H0H18_RS08845 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) H0H18_RS08855 ENOG4105CJN penicillin-binding protein H0H18_RS08860 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) H0H18_RS08865 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) H0H18_RS08870 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) H0H18_RS08875 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) H0H18_RS08880 ENOG4105CNI cell division protein FtsW H0H18_RS08885 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) H0H18_RS08890 ENOG4105DFU Cell wall formation (By similarity) H0H18_RS08895 ENOG4105CPF Cell wall formation (By similarity) H0H18_RS08900 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) H0H18_RS08905 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) H0H18_RS08910 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) H0H18_RS08915 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) H0H18_RS08920 ENOG4108I6A alcohol dehydrogenase H0H18_RS08925 ENOG4105CQC Prephenate dehydratase H0H18_RS08930 ENOG4105ETE Transcriptional regulator (LacI family H0H18_RS08935 ENOG4108RVA ribokinase H0H18_RS08940 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator H0H18_RS08945 ENOG4105CNN ABC, transporter H0H18_RS08950 ENOG4105C2J ABC transporter H0H18_RS08955 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) H0H18_RS08965 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA H0H18_RS08970 ENOG4108UUE Transcriptional regulator H0H18_RS08975 ENOG4105CE7 Amidase, hydantoinase carbamoylase family H0H18_RS08985 ENOG4105D5Q Arginine ornithine antiporter H0H18_RS08990 ENOG4105C3G gtp-binding protein H0H18_RS08995 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) H0H18_RS09000 ENOG4108Z1B Cyclase dehydrase H0H18_RS09005 ENOG4105VDB UPF0125 protein H0H18_RS09010 ENOG4105EZE Cupin 4 family protein H0H18_RS09015 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) H0H18_RS09020 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) H0H18_RS09025 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN H0H18_RS09030 ENOG4108IUZ ABC transporter H0H18_RS09035 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA H0H18_RS09040 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) H0H18_RS09045 ENOG4105DHJ ABC, transporter H0H18_RS09050 ENOG4105CY3 ABC transporter, permease H0H18_RS09055 ENOG4107PE3 Mammalian cell entry related domain protein H0H18_RS09060 ENOG4105E3I toluene tolerance H0H18_RS09070 ENOG4105VFK BolA family H0H18_RS09075 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) H0H18_RS09080 ENOG4108IEC Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) H0H18_RS09085 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH H0H18_RS09090 ENOG4107QNR UPF0135 protein H0H18_RS09095 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) H0H18_RS09100 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase H0H18_RS09105 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) H0H18_RS09110 ENOG4105F0R Cytidylyltransferase H0H18_RS09120 ENOG4105CRK lysyL-tRNA synthetase H0H18_RS09130 ENOG4105T95 Thiol disulfide interChange protein H0H18_RS09135 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) H0H18_RS09145 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) H0H18_RS09150 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) H0H18_RS09155 ENOG4108M8S permease YjgP YjgQ family protein H0H18_RS09160 ENOG4108K5H permease YjgP YjgQ family protein H0H18_RS09165 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) H0H18_RS09170 ENOG4108WJH Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) H0H18_RS09175 ENOG4105E33 succinate dehydrogenase H0H18_RS09180 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) H0H18_RS09185 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) H0H18_RS09190 ENOG4105C4Y ABC transporter H0H18_RS09195 ENOG4107QIJ Aconitate hydratase 2 H0H18_RS09200 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) H0H18_RS09205 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) H0H18_RS09210 ENOG4108IYH Dna topoisomerase H0H18_RS09225 ENOG4108WQI RNA Polymerase H0H18_RS09235 ENOG4105E18 UPF0276 protein H0H18_RS09245 ENOG4109045 doxx family H0H18_RS09250 ENOG4105XJC Two component transcriptional regulator (Winged helix family H0H18_RS09255 ENOG4105DHQ Histidine kinase H0H18_RS09260 ENOG4105X1Q TOBE domain protein H0H18_RS09265 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) H0H18_RS09270 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) H0H18_RS09275 ENOG41065U4 response regulator H0H18_RS09280 ENOG4105YK5 50S ribosomal protein L36 H0H18_RS09285 ENOG4105NRA 50s ribosomal protein l31 type b H0H18_RS09290 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) H0H18_RS09295 ENOG4105DC1 bifunctional purine biosynthesis protein purh H0H18_RS09305 ENOG4105C12 Phosphoribosylglycinamide synthetase H0H18_RS09310 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) H0H18_RS09315 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) H0H18_RS09320 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) H0H18_RS09325 ENOG4105VIE preprotein translocase, subunit YajC H0H18_RS09330 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) H0H18_RS09335 ENOG4105CEE C4-dicarboxylate transporter H0H18_RS09340 ENOG4108KP7 hydrolase H0H18_RS09345 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) H0H18_RS09350 ENOG4105CFP Peptidase U32 H0H18_RS09360 ENOG4105SYT Methylenetetrahydrofolate reductase H0H18_RS09365 ENOG4105DEF Extracellular solute-binding protein, family 5 H0H18_RS09370 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component H0H18_RS09375 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component H0H18_RS09380 ENOG4105C3U ABC transporter H0H18_RS09385 ENOG4108JQ7 (ABC) transporter H0H18_RS09390 ENOG4105FAV ABC, transporter H0H18_RS09395 ENOG4105FDK ABC transporter H0H18_RS09400 ENOG4105DR5 peptidase H0H18_RS09405 ENOG4105C5T Phosphoribosyl pyrophosphate synthase H0H18_RS09410 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) H0H18_RS09420 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate H0H18_RS09430 ENOG4105CJ3 phosphate transporter H0H18_RS09435 ENOG4107IX6 phosphate transport regulator H0H18_RS09440 ENOG4105I7R Adenylate cyclase H0H18_RS09445 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) H0H18_RS09455 ENOG4105EW9 transcriptional regulator AsnC family H0H18_RS09460 ENOG4105CNU cell division protein FtsK H0H18_RS09465 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) H0H18_RS09470 ENOG4105D1H recombination factor protein RarA H0H18_RS09475 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) H0H18_RS09480 ENOG4107T42 This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity) H0H18_RS09485 ENOG4107RUE extracellular solute-binding protein family 1 H0H18_RS09490 ENOG4107RUE extracellular solute-binding protein family 1 H0H18_RS09495 ENOG4105D38 putrescine abc transporter H0H18_RS09500 ENOG4105F38 ABC transporter, permease H0H18_RS09505 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) H0H18_RS09510 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) H0H18_RS09515 ENOG4105DY2 Paraquat-inducible protein b H0H18_RS09520 ENOG4105H2K paraquat-inducible protein a H0H18_RS09525 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) H0H18_RS09530 ENOG4105CN1 protease H0H18_RS09535 ENOG4105DIT ErfK YbiS YcfS YnhG family protein H0H18_RS09540 ENOG4105EAQ (twin-arginine translocation) pathway signal H0H18_RS09545 ENOG4105C5X domain protein H0H18_RS09550 ENOG4105CG6 trap dicarboxylate transporter dctm subunit H0H18_RS09555 ENOG410835K Tripartite ATP-Independent Periplasmic transporter DctQ H0H18_RS09560 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit H0H18_RS09565 ENOG4105BZN citrate synthase H0H18_RS09570 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 H0H18_RS09575 ENOG4105C7S Dehydrogenase H0H18_RS09585 ENOG4105CMV Succinyl-CoA synthetase subunit beta H0H18_RS09590 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha H0H18_RS09595 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) H0H18_RS09600 ENOG4105EYM Major Facilitator superfamily H0H18_RS09605 ENOG4105CMR udp-glucose 4-epimerase H0H18_RS09610 ENOG4105C7N Xanthine uracil vitamin C permease H0H18_RS09620 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) H0H18_RS09625 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) H0H18_RS09630 ENOG4107ARF H0H18_RS09635 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) H0H18_RS09645 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) H0H18_RS09650 ENOG4106QI4 H0H18_RS09655 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) H0H18_RS09660 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase H0H18_RS09710 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family H0H18_RS09715 ENOG4105D0A hydroxylase H0H18_RS09720 ENOG4107RAQ aminopeptidase H0H18_RS09725 ENOG4105E07 UPF0149 protein H0H18_RS09730 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) H0H18_RS09740 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase H0H18_RS09745 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane H0H18_RS09750 ENOG4105C34 Pseudouridine synthase H0H18_RS09755 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase H0H18_RS09805 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) H0H18_RS09810 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) H0H18_RS09815 ENOG4105QEK Transcriptional regulator H0H18_RS09820 ENOG4108R66 Conserved Protein H0H18_RS09825 ENOG4105EVU fructokinase H0H18_RS09830 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) H0H18_RS09850 ENOG4108MX5 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses (By similarity) H0H18_RS09865 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit H0H18_RS09870 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) H0H18_RS09880 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) H0H18_RS09885 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant H0H18_RS09895 ENOG4105SX7 Transporter H0H18_RS09900 ENOG4107ZVW dihydroneopterin aldolase H0H18_RS09905 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) H0H18_RS09910 ENOG4107NPY receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) H0H18_RS09915 ENOG4105EXN Sulfate transport protein CysZ H0H18_RS09920 ENOG4105C6T cysteine synthase H0H18_RS09925 ENOG4105D52 delta-aminolevulinic acid dehydratase H0H18_RS09930 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) H0H18_RS09940 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) H0H18_RS09945 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) H0H18_RS09950 ENOG4105JC1 sterol-binding domain protein H0H18_RS09960 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) H0H18_RS09965 ENOG4105C2I pirin domain protein H0H18_RS09970 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) H0H18_RS09975 ENOG4105E0M Sulfatase H0H18_RS09980 ENOG4105CBG Sulfatase H0H18_RS10000 ENOG4105C4X radical SAM domain protein H0H18_RS10005 ENOG4105C37 (CBS) domain H0H18_RS10010 ENOG4105RX8 Protein of unknown function (DUF1523) H0H18_RS10015 ENOG4105F8V Hydrolase, tatD family H0H18_RS10020 ENOG4107QRG dna polymerase iii H0H18_RS10025 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) H0H18_RS10030 ENOG4105HHA aminodeoxychorismate lyase H0H18_RS10035 ENOG4108JQ1 Dehydrogenase H0H18_RS10040 ENOG4105E66 phosphoriboisomerase A H0H18_RS10045 ENOG4105CSA Coproporphyrinogen iii oxidase H0H18_RS10050 ENOG4105K8R UPF0145 protein H0H18_RS10060 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) H0H18_RS10065 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein H0H18_RS10070 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) H0H18_RS10075 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) H0H18_RS10080 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) H0H18_RS10085 ENOG4105DTN riboflavin biosynthesis protein ribF H0H18_RS10090 ENOG4105CJR Integral membrane protein (MviN H0H18_RS10095 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) H0H18_RS10100 ENOG41062Z9 Membrane H0H18_RS10105 ENOG4105EAC phosphoserine phosphatase H0H18_RS10110 ENOG4108VPT UPF0234 protein H0H18_RS10125 ENOG4105CG6 trap dicarboxylate transporter dctm subunit H0H18_RS10135 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit H0H18_RS10140 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) H0H18_RS10145 ENOG4105CMT Dihydroxyacetone kinase H0H18_RS10150 ENOG4108UTZ Dihydroxyacetone kinase H0H18_RS10160 ENOG4105DKT Transcriptional regulator H0H18_RS10165 ENOG4108YZG isomerase H0H18_RS10170 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit H0H18_RS10180 ENOG4105CG6 trap dicarboxylate transporter dctm subunit H0H18_RS10195 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) H0H18_RS10200 ENOG4105CV1 Transketolase (EC 2.2.1.1) H0H18_RS10205 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) H0H18_RS10210 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) H0H18_RS10230 ENOG4107104 thymidine kinase H0H18_RS10235 ENOG4105DC8 reductase H0H18_RS10240 ENOG4105D6S protein involved in catabolism of external DNA H0H18_RS10245 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) H0H18_RS10250 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) H0H18_RS10255 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family H0H18_RS10260 ENOG4108JQC penicillin-binding protein 1A H0H18_RS10285 ENOG4105E4G Type IV pilus H0H18_RS10290 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) H0H18_RS10295 ENOG4105D49 3-dehydroquinate synthase H0H18_RS10300 ENOG4105DFE Dna adenine methylase H0H18_RS10315 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving H0H18_RS10320 ENOG4105M6F mutator MutT protein H0H18_RS10330 ENOG4105DJF DNA polymerase III, delta' subunit H0H18_RS10340 ENOG4105C8T Leucyl-tRNA synthetase H0H18_RS10355 ENOG4105D6S protein involved in catabolism of external DNA H0H18_RS10365 ENOG410681U heavy metal transport detoxification protein H0H18_RS10375 ENOG4108KS2 transglutaminase domain protein H0H18_RS10380 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) H0H18_RS10385 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) H0H18_RS10390 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) H0H18_RS10395 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) H0H18_RS10400 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase H0H18_RS10405 ENOG410735N H0H18_RS10410 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) H0H18_RS10415 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase H0H18_RS10420 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) H0H18_RS10425 ENOG41074FQ H0H18_RS10430 ENOG4105ECC imidazole-glycerol-phosphate dehydratase H0H18_RS10435 ENOG4105CIH Imidazole acetol-phosphate transaminase H0H18_RS10445 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) H0H18_RS10460 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) H0H18_RS10465 ENOG4105DMQ Methyltransferase H0H18_RS10470 ENOG4105CGH 5'-nucleotidase H0H18_RS10475 ENOG4105CIC tryptophan-specific transport protein H0H18_RS10480 ENOG4105F0N pyrophosphate phospho-hydrolase H0H18_RS10485 ENOG4105ERG peptidase m48, ste24p H0H18_RS10495 ENOG41067XB TonB family H0H18_RS10500 ENOG4105M15 transport protein ExbD H0H18_RS10505 ENOG4105M8K biopolymer transport protein H0H18_RS10510 ENOG4108JU6 CBS domain protein H0H18_RS10515 ENOG4106KVJ cytochrome C assembly protein H0H18_RS10520 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY H0H18_RS10525 ENOG4105E55 glycerol-3-phosphate acyltransferase H0H18_RS10530 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) H0H18_RS10535 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) H0H18_RS10540 ENOG4108VDV Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity) H0H18_RS10545 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) H0H18_RS10550 ENOG4105K9Q Binds to the 23S rRNA (By similarity) H0H18_RS10560 ENOG4105C5F glutamine synthetase H0H18_RS10565 ENOG4105CI3 gtp-binding protein typa H0H18_RS10570 ENOG4105NX3 Membrane H0H18_RS10580 ENOG4108R96 Methyltransferase, YaeB family H0H18_RS10585 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase H0H18_RS10590 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) H0H18_RS10595 ENOG4105C8P )-transporter H0H18_RS10600 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) H0H18_RS10605 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins H0H18_RS10610 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) H0H18_RS10615 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)