locus-tag	class	description
H0H18_RS00010	COG0592	DNA-directed DNA polymerase activity
H0H18_RS00020	COG2226	methyltransferase
H0H18_RS00045	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H0H18_RS00110	COG1216	Glycosyl transferase, family 2
H0H18_RS00115	COG1216	Glycosyl transferase, family 2
H0H18_RS00120	COG1442	glycosyl transferase family 8
H0H18_RS00135	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H0H18_RS00140	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H0H18_RS00145	COG1309	transcriptional regulator
H0H18_RS00150	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H0H18_RS00155	COG1956	GAF domain-containing protein
H0H18_RS00160	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H0H18_RS00170	COG1393	Belongs to the ArsC family
H0H18_RS00175	COG3036	rescue of stalled ribosome
H0H18_RS00245	COG4785	May be involved in cell division
H0H18_RS00250	COG0513	Belongs to the DEAD box helicase family
H0H18_RS00260	COG3842	ATPase activity
H0H18_RS00265	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
H0H18_RS00270	COG0725	ABC transporter, periplasmic molybdate-binding protein
H0H18_RS00290	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
H0H18_RS00295	COG1027	Aspartate ammonia-lyase
H0H18_RS00315	COG4545	Glutaredoxin-related protein
H0H18_RS00350	COG0511	ligase activity, forming carbon-carbon bonds
H0H18_RS00355	COG0439	Biotin carboxylase
H0H18_RS00360	COG3924	membrane
H0H18_RS00365	COG4145	pantothenate transmembrane transporter activity
H0H18_RS00390	COG1196	nuclear chromosome segregation
H0H18_RS00415	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H0H18_RS00420	COG4558	Periplasmic binding protein
H0H18_RS00435	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H0H18_RS00455	COG3691	Protein conserved in bacteria
H0H18_RS00465	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H0H18_RS00475	COG0861	Integral membrane protein TerC family
H0H18_RS00480	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H0H18_RS00480	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H0H18_RS00485	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
H0H18_RS00490	COG3722	fumarate hydratase activity
H0H18_RS00505	COG5645	(Lipo)protein
H0H18_RS00510	COG0210	DNA helicase
H0H18_RS00535	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H0H18_RS00545	COG1238	metal cluster binding
H0H18_RS00560	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H0H18_RS00575	COG0697	spore germination
H0H18_RS00585	COG0561	phosphatase activity
H0H18_RS00590	COG1702	phosphate starvation-inducible protein PhoH
H0H18_RS00605	COG1444	tRNA N-acetyltransferase activity
H0H18_RS00615	COG2194	sulfuric ester hydrolase activity
H0H18_RS00620	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H0H18_RS00625	COG4211	Belongs to the binding-protein-dependent transport system permease family
H0H18_RS00635	COG1879	ABC-type sugar transport system periplasmic component
H0H18_RS00640	COG1609	Transcriptional regulator
H0H18_RS00645	COG1085	galactose-1-phosphate uridylyltransferase
H0H18_RS00655	COG2017	converts alpha-aldose to the beta-anomer
H0H18_RS00675	COG1088	dTDP-glucose 4,6-dehydratase activity
H0H18_RS00700	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
H0H18_RS00710	COG1393	Belongs to the ArsC family
H0H18_RS00720	COG1876	peptidase activity
H0H18_RS00725	COG0494	nUDIX hydrolase
H0H18_RS00730	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H0H18_RS00740	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H0H18_RS00745	COG1596	polysaccharide export
H0H18_RS00755	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H0H18_RS00770	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H0H18_RS00780	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
H0H18_RS00790	COG1086	Polysaccharide biosynthesis protein
H0H18_RS00810	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
H0H18_RS00815	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H0H18_RS00840	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H0H18_RS00865	COG0626	cystathionine gamma-synthase activity
H0H18_RS00885	COG1530	ribonuclease E activity
H0H18_RS00900	COG2056	Na+-H+ antiporter family
H0H18_RS00910	COG0346	lactoylglutathione lyase activity
H0H18_RS00925	COG1755	Isoprenylcysteine carboxyl methyltransferase
H0H18_RS00940	COG0494	nUDIX hydrolase
H0H18_RS00975	COG1271	oxidase subunit
H0H18_RS00980	COG1294	oxidase, subunit
H0H18_RS00995	COG0824	Thioesterase
H0H18_RS01000	COG0811	peptide transport
H0H18_RS01005	COG0848	biopolymer transport protein
H0H18_RS01010	COG3064	Membrane
H0H18_RS01035	COG2165	general secretion pathway protein
H0H18_RS01040	COG4795	General secretion pathway protein
H0H18_RS01055	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
H0H18_RS01060	COG0456	acetyltransferase
H0H18_RS01065	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
H0H18_RS01085	COG1840	ABC-type Fe3 transport system, periplasmic component
H0H18_RS01090	COG1840	ABC-type Fe3 transport system, periplasmic component
H0H18_RS01095	COG1840	ABC-type Fe3 transport system, periplasmic component
H0H18_RS01185	COG0582	viral genome integration into host DNA
H0H18_RS01195	COG0659	secondary active sulfate transmembrane transporter activity
H0H18_RS01200	COG0800	Aldolase
H0H18_RS01215	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H0H18_RS01220	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H0H18_RS01225	COG0084	hydrolase, TatD family'
H0H18_RS01240	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H0H18_RS01240	COG1328	CTP reductase activity
H0H18_RS01245	COG1858	cytochrome C peroxidase
H0H18_RS01255	COG0527	aspartate kinase activity
H0H18_RS01265	COG2860	membrane
H0H18_RS01275	COG3069	C4-dicarboxylate transmembrane transporter activity
H0H18_RS01295	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H0H18_RS01305	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
H0H18_RS01310	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H0H18_RS01315	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
H0H18_RS01320	COG1022	Amp-dependent synthetase and ligase
H0H18_RS01330	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H0H18_RS01350	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H0H18_RS01410	COG0748	coenzyme F420 binding
H0H18_RS01415	COG4771	TonB-dependent receptor
H0H18_RS01415	COG1629	transport
H0H18_RS01425	COG0489	protein tyrosine kinase activity
H0H18_RS01460	COG1518	maintenance of DNA repeat elements
H0H18_RS01470	COG5002	protein histidine kinase activity
H0H18_RS01470	COG0784	Response regulator, receiver
H0H18_RS01470	COG2198	Histidine kinase
H0H18_RS01485	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
H0H18_RS01490	COG1959	2 iron, 2 sulfur cluster binding
H0H18_RS01500	COG0822	iron-sulfur transferase activity
H0H18_RS01505	COG0316	Belongs to the HesB IscA family
H0H18_RS01520	COG0633	Ferredoxin
H0H18_RS01535	COG0741	lytic transglycosylase activity
H0H18_RS01540	COG2350	Protein conserved in bacteria
H0H18_RS01545	COG1607	acyl-coa hydrolase
H0H18_RS01565	COG0497	DNA recombination
H0H18_RS01580	COG1823	symporter activity
H0H18_RS01595	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H0H18_RS01605	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H0H18_RS01610	COG1530	ribonuclease E activity
H0H18_RS01625	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H0H18_RS01630	COG0142	geranyltranstransferase activity
H0H18_RS01645	COG0697	spore germination
H0H18_RS01650	COG0697	spore germination
H0H18_RS01660	COG0735	belongs to the Fur family
H0H18_RS01665	COG0716	FMN binding
H0H18_RS01675	COG0596	Alpha beta hydrolase
H0H18_RS01680	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
H0H18_RS01685	COG0318	PFAM AMP-dependent synthetase and ligase
H0H18_RS01690	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
H0H18_RS01690	COG3264	Mechanosensitive ion channel
H0H18_RS01700	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
H0H18_RS01705	COG0730	response to heat
H0H18_RS01710	COG1560	Kdo2-lipid A biosynthetic process
H0H18_RS01720	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H0H18_RS01730	COG0251	oxidation-reduction process
H0H18_RS01745	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H0H18_RS01750	COG0187	DNA topoisomerase II activity
H0H18_RS01755	COG0019	diaminopimelate decarboxylase activity
H0H18_RS01770	COG4797	methyltransferase
H0H18_RS01770	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H0H18_RS01780	COG4143	(ABC) transporter
H0H18_RS01785	COG1178	ABC-type Fe3 transport system permease component
H0H18_RS01800	COG0733	neurotransmitter:sodium symporter activity
H0H18_RS01805	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H0H18_RS01860	COG1289	transmembrane transporter activity
H0H18_RS01865	COG3304	Inner membrane component domain
H0H18_RS01885	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H0H18_RS01890	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H0H18_RS01895	COG1121	(ABC) transporter
H0H18_RS01905	COG2920	part of a sulfur-relay system
H0H18_RS01925	COG2864	formate dehydrogenase
H0H18_RS01930	COG0437	4 iron, 4 sulfur cluster binding
H0H18_RS01945	COG0210	DNA helicase
H0H18_RS01960	COG0463	Glycosyl transferase, family 2
H0H18_RS01995	COG0583	DNA-binding transcription factor activity
H0H18_RS02005	COG0488	(ABC) transporter
H0H18_RS02010	COG3683	transport system, periplasmic component
H0H18_RS02015	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
H0H18_RS02040	COG5002	protein histidine kinase activity
H0H18_RS02045	COG0745	RESPONSE REGULATOR receiver
H0H18_RS02075	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H0H18_RS02080	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H0H18_RS02090	COG2062	phosphohistidine phosphatase, SixA
H0H18_RS02120	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H0H18_RS02125	COG4181	ATPase activity
H0H18_RS02135	COG1136	(ABC) transporter
H0H18_RS02135	COG0577	efflux transmembrane transporter activity
H0H18_RS02150	COG0672	)-iron permease
H0H18_RS02160	COG2837	iron assimilation
H0H18_RS02165	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H0H18_RS02180	COG0024	Methionine aminopeptidase
H0H18_RS02250	COG2431	L-lysine efflux transmembrane transporter activity
H0H18_RS02255	COG3593	DNA synthesis involved in DNA repair
H0H18_RS02270	COG3101	peptidyl-lysine hydroxylation
H0H18_RS02275	COG1131	(ABC) transporter
H0H18_RS02280	COG0842	Transport permease protein
H0H18_RS02285	COG2358	TRAP transporter, solute receptor (TAXI family
H0H18_RS02300	COG1611	Belongs to the LOG family
H0H18_RS02310	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
H0H18_RS02315	COG3098	single-species biofilm formation
H0H18_RS02340	COG1067	ATP-dependent peptidase activity
H0H18_RS02350	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H0H18_RS02355	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H0H18_RS02365	COG2831	hemolysin activation secretion protein
H0H18_RS02370	COG3210	domain, Protein
H0H18_RS02370	COG3210	domain, Protein
H0H18_RS02475	COG1434	Gram-negative-bacterium-type cell wall biogenesis
H0H18_RS02490	COG3306	glycosyltransferase involved in LPS biosynthesis
H0H18_RS02500	COG1216	Glycosyl transferase, family 2
H0H18_RS02505	COG1216	Glycosyl transferase, family 2
H0H18_RS02510	COG2951	lytic endotransglycosylase activity
H0H18_RS02515	COG2252	PERMEase
H0H18_RS02520	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
H0H18_RS02525	COG1074	ATP-dependent DNA helicase activity
H0H18_RS02530	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H0H18_RS02535	COG2999	glutathione oxidoreductase activity
H0H18_RS02560	COG2969	positive regulation of protein catabolic process
H0H18_RS02565	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
H0H18_RS02570	COG0517	IMP dehydrogenase activity
H0H18_RS02570	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H0H18_RS02585	COG1538	Outer membrane efflux protein
H0H18_RS02595	COG1115	amino acid carrier protein
H0H18_RS02615	COG0142	geranyltranstransferase activity
H0H18_RS02625	COG0243	molybdopterin cofactor binding
H0H18_RS02630	COG3005	denitrification pathway
H0H18_RS02660	COG1640	4-alpha-glucanotransferase
H0H18_RS02670	COG1523	belongs to the glycosyl hydrolase 13 family
H0H18_RS02700	COG1090	epimerase
H0H18_RS02720	COG3102	Protein conserved in bacteria
H0H18_RS02730	COG3133	Outer membrane lipoprotein
H0H18_RS02755	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H0H18_RS02760	COG4591	ABC-type transport system involved in lipoprotein release permease component
H0H18_RS02770	COG4591	ABC-type transport system involved in lipoprotein release permease component
H0H18_RS02775	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H0H18_RS02780	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H0H18_RS02785	COG0402	S-adenosylhomocysteine deaminase activity
H0H18_RS02790	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H0H18_RS02795	COG0583	DNA-binding transcription factor activity
H0H18_RS02805	COG2833	Protein of unknown function (DUF455)
H0H18_RS02810	COG1946	Acyl-CoA thioesterase
H0H18_RS02820	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
H0H18_RS02825	COG4988	ABC transporter
H0H18_RS02830	COG0492	ferredoxin-NADP+ reductase activity
H0H18_RS02835	COG3118	belongs to the thioredoxin family
H0H18_RS02840	COG0288	reversible hydration of carbon dioxide
H0H18_RS02845	COG1629	transport
H0H18_RS02860	COG4221	oxidoreductase activity
H0H18_RS02880	COG0512	Glutamine amidotransferase of anthranilate synthase
H0H18_RS02885	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H0H18_RS02890	COG0616	signal peptide processing
H0H18_RS02905	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H0H18_RS02925	COG0747	negative chemotaxis
H0H18_RS02935	COG0730	response to heat
H0H18_RS02940	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H0H18_RS02945	COG3119	arylsulfatase activity
H0H18_RS02950	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H0H18_RS02955	COG0641	radical SAM
H0H18_RS02960	COG0676	glucose-6-phosphate 1-epimerase activity
H0H18_RS02970	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H0H18_RS03015	COG0697	spore germination
H0H18_RS03020	COG2925	Exonuclease
H0H18_RS03025	COG4575	ribosome binding
H0H18_RS03045	COG0613	PHP domain protein
H0H18_RS03055	COG0308	aminopeptidase N
H0H18_RS03060	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
H0H18_RS03065	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H0H18_RS03070	COG1448	Aminotransferase
H0H18_RS03080	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
H0H18_RS03100	COG0791	NLP P60 protein
H0H18_RS03130	COG0564	pseudouridine synthase activity
H0H18_RS03135	COG0406	alpha-ribazole phosphatase activity
H0H18_RS03140	COG0285	dihydrofolate synthase activity
H0H18_RS03165	COG0586	Pfam SNARE associated Golgi protein
H0H18_RS03175	COG1940	carbohydrate kinase activity
H0H18_RS03185	COG4953	penicillin-binding protein 1C
H0H18_RS03205	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
H0H18_RS03210	COG2823	Periplasmic or secreted lipoprotein
H0H18_RS03215	COG0307	riboflavin synthase, alpha
H0H18_RS03225	COG0673	inositol 2-dehydrogenase activity
H0H18_RS03230	COG0469	pyruvate kinase activity
H0H18_RS03280	COG0305	Participates in initiation and elongation during chromosome replication
H0H18_RS03350	COG3617	BRO family, N-terminal domain
H0H18_RS03395	COG0583	DNA-binding transcription factor activity
H0H18_RS03405	COG0009	L-threonylcarbamoyladenylate synthase
H0H18_RS03410	COG4409	exo-alpha-(2->6)-sialidase activity
H0H18_RS03415	COG1605	Chorismate mutase
H0H18_RS03415	COG0287	Prephenate dehydrogenase
H0H18_RS03420	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H0H18_RS03425	COG1528	Iron-storage protein
H0H18_RS03430	COG1528	Iron-storage protein
H0H18_RS03440	COG0589	response to stress
H0H18_RS03450	COG0616	signal peptide processing
H0H18_RS03455	COG0778	Nitroreductase
H0H18_RS03460	COG0515	serine threonine protein kinase
H0H18_RS03475	COG0671	phosphoesterase, PA-phosphatase related
H0H18_RS03485	COG4166	transmembrane transport
H0H18_RS03490	COG2832	Protein of unknown function (DUF454)
H0H18_RS03495	COG0339	signal peptide processing
H0H18_RS03520	COG1846	Transcriptional regulator
H0H18_RS03520	COG1940	carbohydrate kinase activity
H0H18_RS03535	COG2226	methyltransferase
H0H18_RS03540	COG1944	ATP diphosphatase activity
H0H18_RS03545	COG3105	Protein conserved in bacteria
H0H18_RS03555	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
H0H18_RS03560	COG0708	Exodeoxyribonuclease III
H0H18_RS03575	COG0303	'Molybdopterin
H0H18_RS03580	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H0H18_RS03585	COG0163	prenyltransferase activity
H0H18_RS03595	COG1286	toxin biosynthetic process
H0H18_RS03610	COG0857	belongs to the CobB CobQ family
H0H18_RS03610	COG0280	phosphate acetyltransferase
H0H18_RS03615	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
H0H18_RS03620	COG0318	PFAM AMP-dependent synthetase and ligase
H0H18_RS03625	COG3065	identical protein binding
H0H18_RS03630	COG1214	PFAM Peptidase M22, glycoprotease
H0H18_RS03635	COG1199	ATP-dependent helicase activity
H0H18_RS03640	COG0676	glucose-6-phosphate 1-epimerase activity
H0H18_RS03650	COG1534	Rna-binding protein
H0H18_RS03665	COG2027	D-alanyl-D-alanine carboxypeptidase
H0H18_RS03670	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H0H18_RS03675	COG0733	neurotransmitter:sodium symporter activity
H0H18_RS03685	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H0H18_RS03690	COG0633	Ferredoxin
H0H18_RS03725	COG1280	lysine exporter protein (LysE YggA)
H0H18_RS03730	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H0H18_RS03735	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H0H18_RS03750	COG0814	amino acid
H0H18_RS03760	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H0H18_RS03765	COG5339	Protein conserved in bacteria
H0H18_RS03795	COG1629	transport
H0H18_RS03795	COG4771	TonB-dependent receptor
H0H18_RS03805	COG4149	molybdate abc transporter
H0H18_RS03810	COG0725	ABC transporter, periplasmic molybdate-binding protein
H0H18_RS03820	COG2005	Transcriptional regulator
H0H18_RS03830	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H0H18_RS03835	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H0H18_RS03835	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H0H18_RS03850	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
H0H18_RS03855	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
H0H18_RS03890	COG0195	Participates in both transcription termination and antitermination
H0H18_RS03925	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
H0H18_RS03935	COG3657	addiction module killer protein
H0H18_RS03960	COG0464	growth
H0H18_RS03965	COG1643	Atp-dependent helicase
H0H18_RS03970	COG2363	Small membrane protein
H0H18_RS04005	COG0463	Glycosyl transferase, family 2
H0H18_RS04035	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
H0H18_RS04045	COG1704	LemA family
H0H18_RS04055	COG0277	FAD linked oxidase domain protein
H0H18_RS04055	COG0247	lactate metabolic process
H0H18_RS04075	COG1609	Transcriptional regulator
H0H18_RS04080	COG3265	gluconokinase activity
H0H18_RS04085	COG2610	gluconate transmembrane transporter activity
H0H18_RS04090	COG0626	cystathionine gamma-synthase activity
H0H18_RS04095	COG0450	alkyl hydroperoxide reductase
H0H18_RS04110	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
H0H18_RS04115	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
H0H18_RS04125	COG0539	negative regulation of cytoplasmic translation
H0H18_RS04135	COG4771	TonB-dependent receptor
H0H18_RS04140	COG0612	Peptidase, M16
H0H18_RS04150	COG1982	Orn Lys Arg decarboxylase major
H0H18_RS04155	COG0531	amino acid
H0H18_RS04165	COG2990	Protein conserved in bacteria
H0H18_RS04170	COG0814	amino acid
H0H18_RS04185	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H0H18_RS04195	COG2194	sulfuric ester hydrolase activity
H0H18_RS04205	COG0783	Belongs to the Dps family
H0H18_RS04230	COG2927	DNA polymerase III (CHI subunit)
H0H18_RS04240	COG2268	Band 7 protein
H0H18_RS04255	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H0H18_RS04280	COG3716	PTS system mannose fructose sorbose family IID component
H0H18_RS04285	COG3715	PTS system
H0H18_RS04290	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
H0H18_RS04290	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H0H18_RS04295	COG2814	Major facilitator Superfamily
H0H18_RS04325	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H0H18_RS04330	COG3094	Invasion gene expression up-regulator, SirB
H0H18_RS04380	COG1450	Type ii and iii secretion system protein
H0H18_RS04415	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H0H18_RS04445	COG0658	competence protein
H0H18_RS04445	COG2333	competence protein COMEC
H0H18_RS04455	COG0617	tRNA 3'-terminal CCA addition
H0H18_RS04460	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H0H18_RS04470	COG2949	membrane
H0H18_RS04480	COG0440	acetolactate synthase activity
H0H18_RS04485	COG0028	Belongs to the TPP enzyme family
H0H18_RS04490	COG1757	Na H antiporter
H0H18_RS04495	COG2916	Histone family protein nucleoid-structuring protein H-NS
H0H18_RS04500	COG0788	formyltetrahydrofolate deformylase activity
H0H18_RS04505	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H0H18_RS04515	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H0H18_RS04515	COG1263	PTS System
H0H18_RS04515	COG2190	(PTS) system
H0H18_RS04530	COG1346	cytolysis
H0H18_RS04540	COG1525	nuclease
H0H18_RS04550	COG2166	iron-sulfur cluster assembly
H0H18_RS04560	COG1560	Kdo2-lipid A biosynthetic process
H0H18_RS04565	COG3381	protein complex oligomerization
H0H18_RS04570	COG2249	NAD(P)H dehydrogenase (quinone) activity
H0H18_RS04580	COG0330	HflC and HflK could
H0H18_RS04585	COG1119	ATPase activity
H0H18_RS04595	COG2932	Transcriptional regulator
H0H18_RS04600	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H0H18_RS04605	COG0508	dehydrogenase complex catalyzes the overall conversion of
H0H18_RS04610	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
H0H18_RS04615	COG2190	(PTS) system
H0H18_RS04620	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H0H18_RS04625	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H0H18_RS04650	COG0802	atpase or kinase
H0H18_RS04655	COG0860	N-Acetylmuramoyl-L-alanine amidase
H0H18_RS04655	COG1388	LysM domain
H0H18_RS04675	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H0H18_RS04680	COG3283	Transcriptional regulator of aromatic amino acids metabolism
H0H18_RS04690	COG3106	COG3106 Predicted ATPase
H0H18_RS04695	COG4166	transmembrane transport
H0H18_RS04700	COG4168	peptide transport system, permease
H0H18_RS04705	COG4171	peptide transport system, permease
H0H18_RS04710	COG4172	Belongs to the ABC transporter superfamily
H0H18_RS04715	COG4172	Belongs to the ABC transporter superfamily
H0H18_RS04780	COG3068	Protein conserved in bacteria
H0H18_RS04815	COG2610	gluconate transmembrane transporter activity
H0H18_RS04820	COG1929	Belongs to the glycerate kinase type-1 family
H0H18_RS04840	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H0H18_RS04865	COG2168	tRNA wobble position uridine thiolation
H0H18_RS04880	COG2964	Protein conserved in bacteria
H0H18_RS04885	COG0545	Peptidyl-prolyl cis-trans isomerase
H0H18_RS04895	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H0H18_RS04895	COG0678	peroxiredoxin activity
H0H18_RS04900	COG0583	DNA-binding transcription factor activity
H0H18_RS04905	COG1309	transcriptional regulator
H0H18_RS04910	COG1349	DNA-binding transcription factor activity
H0H18_RS04925	COG2271	Major facilitator Superfamily
H0H18_RS04930	COG2197	response regulator
H0H18_RS04940	COG2271	Major facilitator Superfamily
H0H18_RS04945	COG1230	cation diffusion facilitator family transporter
H0H18_RS04960	COG1477	protein flavinylation
H0H18_RS04995	COG1172	Belongs to the binding-protein-dependent transport system permease family
H0H18_RS05000	COG1129	ABC transporter
H0H18_RS05005	COG1879	ABC-type sugar transport system periplasmic component
H0H18_RS05010	COG0271	Belongs to the BolA IbaG family
H0H18_RS05015	COG3056	Lipoprotein
H0H18_RS05045	COG1194	a g-specific adenine glycosylase
H0H18_RS05050	COG3038	cytochrome b561
H0H18_RS05060	COG3171	Protein conserved in bacteria
H0H18_RS05070	COG0762	integral membrane protein
H0H18_RS05080	COG0456	acetyltransferase
H0H18_RS05090	COG0500	methyltransferase
H0H18_RS05095	COG1120	ATPase activity
H0H18_RS05110	COG0463	Glycosyl transferase, family 2
H0H18_RS05115	COG1519	Transferase
H0H18_RS05130	COG0859	PFAM glycosyl transferase family 9
H0H18_RS05135	COG1132	(ABC) transporter
H0H18_RS05145	COG4772	TonB-dependent receptor
H0H18_RS05155	COG1473	amidohydrolase
H0H18_RS05160	COG3069	C4-dicarboxylate transmembrane transporter activity
H0H18_RS05185	COG0859	PFAM glycosyl transferase family 9
H0H18_RS05190	COG2364	Membrane
H0H18_RS05195	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H0H18_RS05210	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H0H18_RS05230	COG3956	TIGRFAM MazG family protein
H0H18_RS05240	COG0583	DNA-binding transcription factor activity
H0H18_RS05285	COG1129	ABC transporter
H0H18_RS05290	COG2390	Transcriptional regulator
H0H18_RS05295	COG1070	Carbohydrate kinase
H0H18_RS05310	COG0551	DNA topoisomerase type I activity
H0H18_RS05325	COG1116	anion transmembrane transporter activity
H0H18_RS05330	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H0H18_RS05335	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H0H18_RS05340	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H0H18_RS05350	COG0351	phosphomethylpyrimidine kinase
H0H18_RS05360	COG0477	Major facilitator Superfamily
H0H18_RS05370	COG1414	Transcriptional regulator
H0H18_RS05380	COG2731	YhcH YjgK YiaL family protein
H0H18_RS05385	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
H0H18_RS05390	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
H0H18_RS05395	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H0H18_RS05400	COG1129	ABC transporter
H0H18_RS05425	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
H0H18_RS05430	COG3623	hexulose-6-phosphate isomerase
H0H18_RS05435	COG0235	Class ii aldolase
H0H18_RS05440	COG0561	phosphatase activity
H0H18_RS05450	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H0H18_RS05455	COG2267	carboxylic ester hydrolase activity
H0H18_RS05465	COG0561	phosphatase activity
H0H18_RS05475	COG3978	acetolactate synthase activity
H0H18_RS05480	COG1794	racemase activity, acting on amino acids and derivatives
H0H18_RS05515	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H0H18_RS05540	COG4942	peptidase
H0H18_RS05540	COG1388	LysM domain
H0H18_RS05550	COG1238	metal cluster binding
H0H18_RS05585	COG0538	isocitrate dehydrogenase activity
H0H18_RS05610	COG2818	Glycosylase
H0H18_RS05620	COG0758	DNA mediated transformation
H0H18_RS05625	COG3005	denitrification pathway
H0H18_RS05630	COG3043	anaerobic respiration
H0H18_RS05635	COG0348	domain, Protein
H0H18_RS05640	COG0437	4 iron, 4 sulfur cluster binding
H0H18_RS05650	COG3062	negative regulation of establishment of protein localization
H0H18_RS05655	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H0H18_RS05660	COG3850	Histidine kinase
H0H18_RS05680	COG1275	C4-dicarboxylate transporter malic acid transport protein
H0H18_RS05685	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H0H18_RS05690	COG0471	metal ion transport
H0H18_RS05695	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H0H18_RS05710	COG2095	MarC family integral membrane protein
H0H18_RS05725	COG2358	TRAP transporter, solute receptor (TAXI family
H0H18_RS05750	COG1522	sequence-specific DNA binding
H0H18_RS05755	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
H0H18_RS05770	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H0H18_RS05775	COG2841	Protein conserved in bacteria
H0H18_RS05790	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
H0H18_RS05800	COG0569	domain protein
H0H18_RS05805	COG1215	transferase activity, transferring glycosyl groups
H0H18_RS05845	COG3070	regulator of competence-specific genes
H0H18_RS05855	COG1040	competence protein
H0H18_RS05885	COG0363	glucosamine-6-phosphate deaminase activity
H0H18_RS05890	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H0H18_RS05895	COG1218	3'(2'),5'-bisphosphate nucleotidase
H0H18_RS05905	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
H0H18_RS05910	COG1011	Hydrolase
H0H18_RS05915	COG0494	nUDIX hydrolase
H0H18_RS05930	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
H0H18_RS05940	COG0732	type I restriction modification DNA specificity domain
H0H18_RS05945	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
H0H18_RS05960	COG3971	2-oxopent-4-enoate hydratase activity
H0H18_RS05965	COG2814	Major facilitator Superfamily
H0H18_RS05975	COG3384	dioxygenase
H0H18_RS05980	COG1012	belongs to the aldehyde dehydrogenase family
H0H18_RS06025	COG2177	Part of the ABC transporter FtsEX involved in
H0H18_RS06030	COG2884	Cell division ATP-binding protein ftsE
H0H18_RS06035	COG0552	protein localization to endoplasmic reticulum
H0H18_RS06045	COG0742	ribosomal rna small subunit methyltransferase
H0H18_RS06060	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H0H18_RS06065	COG2990	Protein conserved in bacteria
H0H18_RS06075	COG0606	chelatase, subunit chli
H0H18_RS06090	COG2861	carbohydrate metabolic process
H0H18_RS06095	COG4942	peptidase
H0H18_RS06125	COG2853	Lipoprotein
H0H18_RS06170	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H0H18_RS06175	COG1739	Uncharacterized protein family UPF0029
H0H18_RS06250	COG1494	fructose-1,6-bisphosphatase
H0H18_RS06255	COG0640	Transcriptional regulator
H0H18_RS06260	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H0H18_RS06280	COG0187	DNA topoisomerase II activity
H0H18_RS06285	COG0697	spore germination
H0H18_RS06290	COG4988	ABC transporter
H0H18_RS06295	COG1132	(ABC) transporter
H0H18_RS06305	COG1733	regulation of RNA biosynthetic process
H0H18_RS06310	COG1881	PFAM PEBP family protein
H0H18_RS06335	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H0H18_RS06345	COG0512	Glutamine amidotransferase of anthranilate synthase
H0H18_RS06380	COG3842	ATPase activity
H0H18_RS06390	COG3842	ATPase activity
H0H18_RS06395	COG1454	alcohol dehydrogenase
H0H18_RS06395	COG1012	belongs to the aldehyde dehydrogenase family
H0H18_RS06400	COG1584	GPR1 FUN34 yaaH family protein
H0H18_RS06420	COG2183	response to ionizing radiation
H0H18_RS06435	COG0732	type I restriction modification DNA specificity domain
H0H18_RS06460	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H0H18_RS06465	COG0584	glycerophosphoryl diester phosphodiesterase
H0H18_RS06470	COG2271	Major facilitator Superfamily
H0H18_RS06475	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
H0H18_RS06485	COG0247	lactate metabolic process
H0H18_RS06490	COG1349	DNA-binding transcription factor activity
H0H18_RS06495	COG0705	Rhomboid family
H0H18_RS06510	COG0433	COG0433 Predicted ATPase
H0H18_RS06515	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
H0H18_RS06520	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H0H18_RS06535	COG1045	serine acetyltransferase
H0H18_RS06540	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H0H18_RS06555	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
H0H18_RS06565	COG0019	diaminopimelate decarboxylase activity
H0H18_RS06595	COG0814	amino acid
H0H18_RS06605	COG0038	chloride channel
H0H18_RS06615	COG0051	transcription antitermination factor activity, RNA binding
H0H18_RS06640	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H0H18_RS06645	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H0H18_RS06720	COG0201	protein transport
H0H18_RS06755	COG2129	metallophosphoesterase
H0H18_RS06760	COG3172	ATPase kinase involved in NAD metabolism
H0H18_RS06765	COG2960	long-chain fatty acid transporting porin activity
H0H18_RS06775	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
H0H18_RS06780	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H0H18_RS06795	COG0784	Response regulator, receiver
H0H18_RS06795	COG4191	Histidine kinase
H0H18_RS06800	COG1017	nitric oxide dioxygenase activity
H0H18_RS06800	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H0H18_RS06810	COG1741	Belongs to the pirin family
H0H18_RS06820	COG1172	Belongs to the binding-protein-dependent transport system permease family
H0H18_RS06835	COG1940	carbohydrate kinase activity
H0H18_RS06855	COG2207	Transcriptional regulator
H0H18_RS06855	COG1609	Transcriptional regulator
H0H18_RS06860	COG4214	carbohydrate transport
H0H18_RS06865	COG1129	ABC transporter
H0H18_RS06870	COG4213	ABC transporter substrate-binding protein
H0H18_RS06875	COG1757	Na H antiporter
H0H18_RS06885	COG2115	Belongs to the xylose isomerase family
H0H18_RS06890	COG1070	Carbohydrate kinase
H0H18_RS06900	COG0800	Aldolase
H0H18_RS06905	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H0H18_RS06915	COG1028	Short-chain dehydrogenase reductase Sdr
H0H18_RS06925	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
H0H18_RS06930	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H0H18_RS06935	COG2186	Transcriptional regulator
H0H18_RS06940	COG1312	Catalyzes the dehydration of D-mannonate
H0H18_RS06950	COG2195	Cleaves the N-terminal amino acid of tripeptides
H0H18_RS06955	COG1349	DNA-binding transcription factor activity
H0H18_RS06960	COG2084	Dehydrogenase
H0H18_RS06965	COG3395	kinase activity
H0H18_RS06970	COG0235	Class ii aldolase
H0H18_RS06975	COG3622	Belongs to the hyi family
H0H18_RS06990	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H0H18_RS06995	COG2610	gluconate transmembrane transporter activity
H0H18_RS07050	COG1263	PTS System
H0H18_RS07050	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H0H18_RS07050	COG2190	(PTS) system
H0H18_RS07055	COG1285	pathogenesis
H0H18_RS07060	COG0243	molybdopterin cofactor binding
H0H18_RS07065	COG0437	4 iron, 4 sulfur cluster binding
H0H18_RS07070	COG3302	dmso reductase anchor subunit
H0H18_RS07075	COG3381	protein complex oligomerization
H0H18_RS07080	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H0H18_RS07080	COG2221	Nitrite and sulphite reductase 4Fe-4S
H0H18_RS07085	COG3276	selenocysteine insertion sequence binding
H0H18_RS07090	COG1957	nucleoside hydrolase
H0H18_RS07105	COG2814	Major facilitator Superfamily
H0H18_RS07110	COG1763	Mo-molybdopterin cofactor biosynthetic process
H0H18_RS07115	COG3086	response to oxidative stress
H0H18_RS07120	COG3026	antisigma factor binding
H0H18_RS07125	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
H0H18_RS07130	COG1595	DNA-templated transcription, initiation
H0H18_RS07140	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H0H18_RS07150	COG3005	denitrification pathway
H0H18_RS07165	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
H0H18_RS07165	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H0H18_RS07165	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H0H18_RS07170	COG1105	Belongs to the carbohydrate kinase PfkB family
H0H18_RS07175	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H0H18_RS07175	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H0H18_RS07190	COG3084	Protein conserved in bacteria
H0H18_RS07195	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H0H18_RS07200	COG3085	chromosome segregation
H0H18_RS07225	COG0248	Ppx GppA phosphatase
H0H18_RS07230	COG2911	Protein conserved in bacteria
H0H18_RS07235	COG0729	surface antigen
H0H18_RS07240	COG2197	response regulator
H0H18_RS07260	COG2959	enzyme of heme biosynthesis
H0H18_RS07265	COG3071	HemY protein
H0H18_RS07305	COG1136	(ABC) transporter
H0H18_RS07305	COG0577	efflux transmembrane transporter activity
H0H18_RS07315	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H0H18_RS07350	COG0778	Nitroreductase
H0H18_RS07355	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H0H18_RS07380	COG3201	nicotinamide mononucleotide transporter
H0H18_RS07390	COG0513	Belongs to the DEAD box helicase family
H0H18_RS07395	COG0859	PFAM glycosyl transferase family 9
H0H18_RS07400	COG0859	PFAM glycosyl transferase family 9
H0H18_RS07420	COG1621	beta-fructofuranosidase activity
H0H18_RS07425	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H0H18_RS07435	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H0H18_RS07440	COG1620	l-lactate permease
H0H18_RS07445	COG0247	lactate metabolic process
H0H18_RS07450	COG1139	Iron-sulfur cluster binding protein
H0H18_RS07455	COG1556	Lactate utilization protein
H0H18_RS07460	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H0H18_RS07465	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H0H18_RS07470	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H0H18_RS07475	COG3719	Belongs to the RNase T2 family
H0H18_RS07485	COG0191	fructose-bisphosphate aldolase activity
H0H18_RS07490	COG3307	-O-antigen
H0H18_RS07495	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H0H18_RS07500	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H0H18_RS07515	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H0H18_RS07545	COG0354	folic acid binding
H0H18_RS07550	COG1561	YicC-like family, N-terminal region
H0H18_RS07580	COG1011	Hydrolase
H0H18_RS07585	COG0402	S-adenosylhomocysteine deaminase activity
H0H18_RS07590	COG3083	sulfuric ester hydrolase activity
H0H18_RS07605	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H0H18_RS07610	COG0745	RESPONSE REGULATOR receiver
H0H18_RS07615	COG2205	protein histidine kinase activity
H0H18_RS07620	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
H0H18_RS07630	COG2608	mercury ion transmembrane transporter activity
H0H18_RS07635	COG2217	Heavy metal translocating P-type atpase
H0H18_RS07640	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H0H18_RS07645	COG3610	response to peptide
H0H18_RS07650	COG2966	Psort location CytoplasmicMembrane, score
H0H18_RS07665	COG0545	Peptidyl-prolyl cis-trans isomerase
H0H18_RS07675	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H0H18_RS07685	COG2830	Protein of unknown function (DUF452)
H0H18_RS07690	COG0500	methyltransferase
H0H18_RS07705	COG4608	Belongs to the ABC transporter superfamily
H0H18_RS07715	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H0H18_RS07720	COG0601	transmembrane transport
H0H18_RS07730	COG1399	metal-binding, possibly nucleic acid-binding protein
H0H18_RS07750	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H0H18_RS07755	COG1028	Short-chain dehydrogenase reductase Sdr
H0H18_RS07765	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
H0H18_RS07775	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
H0H18_RS07785	COG0799	negative regulation of ribosome biogenesis
H0H18_RS07795	COG0768	penicillin binding
H0H18_RS07800	COG0772	Belongs to the SEDS family
H0H18_RS07810	COG1686	Belongs to the peptidase S11 family
H0H18_RS07880	COG0557	exoribonuclease II activity
H0H18_RS07890	COG1792	Involved in formation and maintenance of cell shape
H0H18_RS07895	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
H0H18_RS07925	COG1349	DNA-binding transcription factor activity
H0H18_RS07930	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H0H18_RS07935	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H0H18_RS07940	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
H0H18_RS07945	COG1028	Short-chain dehydrogenase reductase Sdr
H0H18_RS07960	COG3730	PTS system glucitol sorbitol-specific
H0H18_RS07965	COG2321	neutral zinc metallopeptidase
H0H18_RS07970	COG1652	LysM domain
H0H18_RS07990	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H0H18_RS07995	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H0H18_RS08000	COG1538	Outer membrane efflux protein
H0H18_RS08005	COG0842	Transport permease protein
H0H18_RS08010	COG0842	Transport permease protein
H0H18_RS08010	COG1129	ABC transporter
H0H18_RS08015	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H0H18_RS08050	COG0575	Belongs to the CDS family
H0H18_RS08095	COG0471	metal ion transport
H0H18_RS08095	COG0490	domain, Protein
H0H18_RS08100	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H0H18_RS08110	COG4589	Belongs to the CDS family
H0H18_RS08115	COG0521	Mo-molybdopterin cofactor biosynthetic process
H0H18_RS08125	COG0628	permease
H0H18_RS08135	COG3063	Type IV pilus biogenesis stability protein PilW
H0H18_RS08140	COG1426	Protein conserved in bacteria
H0H18_RS08155	COG2976	Protein conserved in bacteria
H0H18_RS08165	COG0737	Belongs to the 5'-nucleotidase family
H0H18_RS08175	COG0281	malic enzyme
H0H18_RS08175	COG0280	phosphate acetyltransferase
H0H18_RS08185	COG2814	Major facilitator Superfamily
H0H18_RS08195	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H0H18_RS08200	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H0H18_RS08205	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H0H18_RS08215	COG1138	Cytochrome C-type biogenesis protein
H0H18_RS08235	COG0346	lactoylglutathione lyase activity
H0H18_RS08250	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H0H18_RS08265	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H0H18_RS08285	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
H0H18_RS08290	COG0437	4 iron, 4 sulfur cluster binding
H0H18_RS08295	COG3301	Polysulphide reductase, NrfD
H0H18_RS08300	COG1138	Cytochrome C-type biogenesis protein
H0H18_RS08310	COG3088	subunit of a heme lyase
H0H18_RS08310	COG4235	cytochrome complex assembly
H0H18_RS08315	COG4235	cytochrome complex assembly
H0H18_RS08315	COG3088	subunit of a heme lyase
H0H18_RS08320	COG2081	HI0933 family
H0H18_RS08325	COG0753	catalase activity
H0H18_RS08335	COG3738	Protein conserved in bacteria
H0H18_RS08340	COG1760	l-serine dehydratase
H0H18_RS08345	COG0814	amino acid
H0H18_RS08350	COG0121	glutamine amidotransferase
H0H18_RS08365	COG4178	(ABC) transporter
H0H18_RS08370	COG0748	coenzyme F420 binding
H0H18_RS08375	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H0H18_RS08380	COG2095	MarC family integral membrane protein
H0H18_RS08410	COG3842	ATPase activity
H0H18_RS08425	COG0436	Aminotransferase
H0H18_RS08440	COG2267	carboxylic ester hydrolase activity
H0H18_RS08465	COG0681	Belongs to the peptidase S26 family
H0H18_RS08495	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
H0H18_RS08520	COG0537	adenosine 5'-monophosphoramidase activity
H0H18_RS08525	COG2116	formate transmembrane transporter activity
H0H18_RS08530	COG1882	Formate acetyltransferase
H0H18_RS08540	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H0H18_RS08545	COG0590	tRNA wobble adenosine to inosine editing
H0H18_RS08560	COG0730	response to heat
H0H18_RS08570	COG3023	N-Acetylmuramoyl-L-alanine amidase
H0H18_RS08575	COG4969	Belongs to the N-Me-Phe pilin family
H0H18_RS08580	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H0H18_RS08585	COG1459	type II secretion system
H0H18_RS08610	COG1115	amino acid carrier protein
H0H18_RS08615	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H0H18_RS08625	COG2814	Major facilitator Superfamily
H0H18_RS08645	COG3266	domain, Protein
H0H18_RS08645	COG3061	Opacity-associated protein A
H0H18_RS08650	COG1509	lysine 2,3-aminomutase activity
H0H18_RS08660	COG5413	integral membrane protein
H0H18_RS08670	COG0204	Acyl-transferase
H0H18_RS08740	COG0527	aspartate kinase activity
H0H18_RS08740	COG0460	homoserine dehydrogenase
H0H18_RS08750	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H0H18_RS08760	COG0330	HflC and HflK could
H0H18_RS08765	COG0330	HflC and HflK could
H0H18_RS08775	COG0312	modulator of DNA gyrase
H0H18_RS08780	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
H0H18_RS08790	COG1126	abc transporter atp-binding protein
H0H18_RS08795	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H0H18_RS08800	COG4215	(ABC) transporter
H0H18_RS08805	COG4160	amino acid transport
H0H18_RS08815	COG1120	ATPase activity
H0H18_RS08820	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H0H18_RS08825	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H0H18_RS08830	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
H0H18_RS08835	COG1966	Carbon starvation protein
H0H18_RS08850	COG3116	cell division
H0H18_RS08855	COG0768	penicillin binding
H0H18_RS08865	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H0H18_RS08900	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H0H18_RS08905	COG0849	cell division
H0H18_RS08910	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H0H18_RS08920	COG1979	alcohol dehydrogenase
H0H18_RS08925	COG1605	Chorismate mutase
H0H18_RS08925	COG0077	Prephenate dehydratase
H0H18_RS08935	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H0H18_RS08940	COG1879	ABC-type sugar transport system periplasmic component
H0H18_RS08945	COG1172	Belongs to the binding-protein-dependent transport system permease family
H0H18_RS08965	COG2824	Alkylphosphonate utilization operon protein PhnA
H0H18_RS08970	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
H0H18_RS08975	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H0H18_RS08985	COG0531	amino acid
H0H18_RS09000	COG2867	negative regulation of translational initiation
H0H18_RS09010	COG2850	peptidyl-arginine hydroxylation
H0H18_RS09025	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H0H18_RS09030	COG1137	ATPase activity
H0H18_RS09035	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
H0H18_RS09040	COG3117	lipopolysaccharide transmembrane transporter activity
H0H18_RS09045	COG1127	ABC transporter
H0H18_RS09050	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H0H18_RS09055	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H0H18_RS09060	COG2854	intermembrane phospholipid transfer
H0H18_RS09065	COG3113	response to antibiotic
H0H18_RS09070	COG5007	Belongs to the BolA IbaG family
H0H18_RS09085	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H0H18_RS09095	COG0602	queuosine metabolic process
H0H18_RS09100	COG0720	synthase
H0H18_RS09110	COG1083	cytidylyl-transferase
H0H18_RS09135	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H0H18_RS09140	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H0H18_RS09155	COG0795	lipopolysaccharide-transporting ATPase activity
H0H18_RS09160	COG0795	lipopolysaccharide-transporting ATPase activity
H0H18_RS09175	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H0H18_RS09180	COG1053	succinate dehydrogenase
H0H18_RS09190	COG1840	ABC-type Fe3 transport system, periplasmic component
H0H18_RS09225	COG1595	DNA-templated transcription, initiation
H0H18_RS09230	COG3219	Protein conserved in bacteria
H0H18_RS09245	COG2259	Doxx family
H0H18_RS09250	COG0745	RESPONSE REGULATOR receiver
H0H18_RS09255	COG0642	Histidine kinase
H0H18_RS09260	COG3585	molybdate ion transport
H0H18_RS09275	COG0745	RESPONSE REGULATOR receiver
H0H18_RS09280	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H0H18_RS09315	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H0H18_RS09320	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H0H18_RS09325	COG1862	Preprotein translocase
H0H18_RS09335	COG3069	C4-dicarboxylate transmembrane transporter activity
H0H18_RS09340	COG0561	phosphatase activity
H0H18_RS09360	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H0H18_RS09365	COG0747	negative chemotaxis
H0H18_RS09370	COG0601	transmembrane transport
H0H18_RS09375	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H0H18_RS09380	COG0444	Belongs to the ABC transporter superfamily
H0H18_RS09385	COG4608	Belongs to the ABC transporter superfamily
H0H18_RS09390	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H0H18_RS09400	COG0739	heme binding
H0H18_RS09425	COG4991	sh3 domain protein
H0H18_RS09430	COG0306	phosphate transporter
H0H18_RS09435	COG1392	Phosphate transport regulator
H0H18_RS09440	COG3025	triphosphatase activity
H0H18_RS09445	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
H0H18_RS09455	COG1522	sequence-specific DNA binding
H0H18_RS09470	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H0H18_RS09485	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
H0H18_RS09490	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
H0H18_RS09495	COG1177	transmembrane transport
H0H18_RS09500	COG1176	ABC-type spermidine putrescine transport system, permease component I
H0H18_RS09515	COG3008	intermembrane lipid transfer
H0H18_RS09520	COG2995	paraquat-inducible protein a
H0H18_RS09530	COG0793	Belongs to the peptidase S41A family
H0H18_RS09535	COG2989	Protein conserved in bacteria
H0H18_RS09540	COG3108	Peptidase M15
H0H18_RS09545	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H0H18_RS09570	COG0567	Dehydrogenase, E1 component
H0H18_RS09575	COG0508	dehydrogenase complex catalyzes the overall conversion of
H0H18_RS09590	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
H0H18_RS09600	COG2814	Major facilitator Superfamily
H0H18_RS09610	COG2252	PERMEase
H0H18_RS09660	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
H0H18_RS09660	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
H0H18_RS09710	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H0H18_RS09715	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H0H18_RS09720	COG0006	proline dipeptidase activity
H0H18_RS09740	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H0H18_RS09815	COG1737	Transcriptional regulator
H0H18_RS09820	COG2731	YhcH YjgK YiaL family protein
H0H18_RS09855	COG4232	protein-disulfide reductase activity
H0H18_RS09885	COG1011	Hydrolase
H0H18_RS09895	COG0697	spore germination
H0H18_RS09900	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
H0H18_RS09920	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H0H18_RS09930	COG0805	protein transport
H0H18_RS09975	COG1368	sulfuric ester hydrolase activity
H0H18_RS09980	COG3119	arylsulfatase activity
H0H18_RS10000	COG0641	radical SAM
H0H18_RS10005	COG1253	flavin adenine dinucleotide binding
H0H18_RS10015	COG0084	hydrolase, TatD family'
H0H18_RS10020	COG0470	DNA polymerase III
H0H18_RS10030	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H0H18_RS10035	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H0H18_RS10045	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H0H18_RS10065	COG1555	photosystem II stabilization
H0H18_RS10085	COG0196	riboflavin kinase activity
H0H18_RS10090	COG0728	peptidoglycan biosynthetic process
H0H18_RS10105	COG0560	Phosphoserine phosphatase
H0H18_RS10125	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
H0H18_RS10125	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
H0H18_RS10135	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H0H18_RS10145	COG2376	Dihydroxyacetone kinase
H0H18_RS10150	COG1461	Dihydroxyacetone kinase
H0H18_RS10160	COG2390	Transcriptional regulator
H0H18_RS10165	COG0698	ribose 5-phosphate isomerase
H0H18_RS10170	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H0H18_RS10180	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
H0H18_RS10205	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H0H18_RS10235	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H0H18_RS10240	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H0H18_RS10255	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H0H18_RS10260	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
H0H18_RS10265	COG4972	Pilus assembly protein
H0H18_RS10285	COG4796	Type ii and iii secretion system protein
H0H18_RS10300	COG0338	D12 class N6 adenine-specific DNA methyltransferase
H0H18_RS10305	COG4701	Protein of unknown function (DUF721)
H0H18_RS10320	COG0494	nUDIX hydrolase
H0H18_RS10330	COG1466	dna polymerase III delta subunit
H0H18_RS10335	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
H0H18_RS10355	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H0H18_RS10365	COG2608	mercury ion transmembrane transporter activity
H0H18_RS10375	COG1305	Transglutaminase-like
H0H18_RS10390	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H0H18_RS10465	COG2226	methyltransferase
H0H18_RS10470	COG0737	Belongs to the 5'-nucleotidase family
H0H18_RS10475	COG0814	amino acid
H0H18_RS10485	COG4783	chaperone-mediated protein folding
H0H18_RS10500	COG0848	biopolymer transport protein
H0H18_RS10505	COG0811	peptide transport
H0H18_RS10510	COG4536	flavin adenine dinucleotide binding
H0H18_RS10515	COG4137	Cytochrome C assembly protein
H0H18_RS10520	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H0H18_RS10570	COG3739	integral membrane protein
H0H18_RS10580	COG1720	tRNA m6t6A37 methyltransferase activity
H0H18_RS10585	COG1575	Belongs to the MenA family. Type 1 subfamily
H0H18_RS10595	COG0471	metal ion transport