locus-tag	class	description
A4G20_RS00010	COG0303	'Molybdopterin
A4G20_RS00015	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A4G20_RS00025	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A4G20_RS00030	COG1349	DNA-binding transcription factor activity
A4G20_RS00035	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A4G20_RS00040	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
A4G20_RS00050	COG3038	cytochrome b561
A4G20_RS00055	COG1876	peptidase activity
A4G20_RS00060	COG0742	ribosomal rna small subunit methyltransferase
A4G20_RS00085	COG0626	cystathionine gamma-synthase activity
A4G20_RS00095	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A4G20_RS00100	COG4166	transmembrane transport
A4G20_RS00110	COG2268	Band 7 protein
A4G20_RS00130	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
A4G20_RS00135	COG1263	PTS System
A4G20_RS00135	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A4G20_RS00150	COG0308	aminopeptidase N
A4G20_RS00155	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A4G20_RS00165	COG2960	long-chain fatty acid transporting porin activity
A4G20_RS00170	COG0166	Belongs to the GPI family
A4G20_RS00175	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A4G20_RS00180	COG0563	adenylate kinase activity
A4G20_RS00185	COG0557	exoribonuclease II activity
A4G20_RS00190	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A4G20_RS00195	COG1882	Formate acetyltransferase
A4G20_RS00200	COG2116	formate transmembrane transporter activity
A4G20_RS00205	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
A4G20_RS00215	COG3111	PFAM Bacterial OB fold (BOF) protein
A4G20_RS00220	COG2860	membrane
A4G20_RS00255	COG1194	a g-specific adenine glycosylase
A4G20_RS00260	COG0346	lactoylglutathione lyase activity
A4G20_RS00270	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
A4G20_RS00275	COG1473	amidohydrolase
A4G20_RS00285	COG3133	Outer membrane lipoprotein
A4G20_RS00290	COG3102	Protein conserved in bacteria
A4G20_RS00295	COG0018	arginyl-trna synthetase
A4G20_RS00300	COG1914	H( )-stimulated, divalent metal cation uptake system
A4G20_RS00305	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
A4G20_RS00310	COG1984	allophanate hydrolase subunit 2
A4G20_RS00320	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A4G20_RS00330	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A4G20_RS00335	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A4G20_RS00340	COG0617	tRNA 3'-terminal CCA addition
A4G20_RS00345	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A4G20_RS00365	COG2852	Protein conserved in bacteria
A4G20_RS00395	COG4656	Part of a membrane complex involved in electron transport
A4G20_RS00400	COG2878	Part of a membrane complex involved in electron transport
A4G20_RS00405	COG4657	Part of a membrane complex involved in electron transport
A4G20_RS00415	COG4974	Belongs to the 'phage' integrase family
A4G20_RS00460	COG1793	dna ligase
A4G20_RS00480	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A4G20_RS00490	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
A4G20_RS00495	COG2264	protein methyltransferase activity
A4G20_RS00515	COG0758	DNA mediated transformation
A4G20_RS00525	COG3047	cAMP biosynthetic process
A4G20_RS00535	COG3021	interspecies interaction between organisms
A4G20_RS00540	COG0673	inositol 2-dehydrogenase activity
A4G20_RS00545	COG0395	ABC-type sugar transport system, permease component
A4G20_RS00550	COG1175	transmembrane transport
A4G20_RS00560	COG3842	ATPase activity
A4G20_RS00565	COG2186	Transcriptional regulator
A4G20_RS00585	COG3120	sequence-specific DNA binding
A4G20_RS00590	COG1067	ATP-dependent peptidase activity
A4G20_RS00605	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
A4G20_RS00625	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
A4G20_RS00630	COG0583	DNA-binding transcription factor activity
A4G20_RS00635	COG0456	acetyltransferase
A4G20_RS00640	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A4G20_RS00650	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A4G20_RS00660	COG2056	Na+-H+ antiporter family
A4G20_RS00665	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A4G20_RS00670	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A4G20_RS00705	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A4G20_RS00710	COG0564	pseudouridine synthase activity
A4G20_RS00720	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A4G20_RS00725	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A4G20_RS00730	COG0805	protein transport
A4G20_RS00765	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A4G20_RS00775	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A4G20_RS00780	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A4G20_RS00790	COG0089	rRNA binding
A4G20_RS00795	COG0088	Forms part of the polypeptide exit tunnel
A4G20_RS00805	COG0051	transcription antitermination factor activity, RNA binding
A4G20_RS00815	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A4G20_RS00855	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A4G20_RS00865	COG3691	Protein conserved in bacteria
A4G20_RS00875	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A4G20_RS00880	COG0730	response to heat
A4G20_RS00885	COG0840	transmembrane signaling receptor activity
A4G20_RS00900	COG0202	RNA polymerase activity
A4G20_RS00905	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A4G20_RS00915	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A4G20_RS00925	COG0201	protein transport
A4G20_RS00930	COG0200	Binds to the 23S rRNA
A4G20_RS00940	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A4G20_RS00950	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A4G20_RS00955	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A4G20_RS00960	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A4G20_RS00995	COG0107	imidazoleglycerol-phosphate synthase activity
A4G20_RS01000	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
A4G20_RS01030	COG2358	TRAP transporter, solute receptor (TAXI family
A4G20_RS01060	COG0477	Major facilitator Superfamily
A4G20_RS01065	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
A4G20_RS01070	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
A4G20_RS01075	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A4G20_RS01090	COG0521	Mo-molybdopterin cofactor biosynthetic process
A4G20_RS01100	COG3266	domain, Protein
A4G20_RS01100	COG3061	Opacity-associated protein A
A4G20_RS01105	COG1555	photosystem II stabilization
A4G20_RS01115	COG0702	epimerase
A4G20_RS01125	COG3077	Addiction module antitoxin, RelB DinJ family
A4G20_RS01130	COG3041	Addiction module toxin RelE StbE family
A4G20_RS01135	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A4G20_RS01140	COG1763	Mo-molybdopterin cofactor biosynthetic process
A4G20_RS01145	COG3084	Protein conserved in bacteria
A4G20_RS01150	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A4G20_RS01165	COG2995	paraquat-inducible protein a
A4G20_RS01205	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
A4G20_RS01215	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A4G20_RS01220	COG1686	Belongs to the peptidase S11 family
A4G20_RS01230	COG0772	Belongs to the SEDS family
A4G20_RS01240	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
A4G20_RS01245	COG0799	negative regulation of ribosome biogenesis
A4G20_RS01250	COG0024	Methionine aminopeptidase
A4G20_RS01255	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
A4G20_RS01255	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
A4G20_RS01265	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A4G20_RS01285	COG0596	Alpha beta hydrolase
A4G20_RS01315	COG0085	RNA polymerase activity
A4G20_RS01335	COG0222	ribosome binding
A4G20_RS01340	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A4G20_RS01345	COG2190	(PTS) system
A4G20_RS01345	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A4G20_RS01345	COG1263	PTS System
A4G20_RS01355	COG0357	Ribosomal RNA small subunit methyltransferase G
A4G20_RS01370	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
A4G20_RS01400	COG3623	hexulose-6-phosphate isomerase
A4G20_RS01405	COG0235	Class ii aldolase
A4G20_RS01410	COG1739	Uncharacterized protein family UPF0029
A4G20_RS01415	COG2358	TRAP transporter, solute receptor (TAXI family
A4G20_RS01430	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4G20_RS01450	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A4G20_RS01455	COG1309	transcriptional regulator
A4G20_RS01460	COG0583	DNA-binding transcription factor activity
A4G20_RS01465	COG0678	peroxiredoxin activity
A4G20_RS01465	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A4G20_RS01470	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
A4G20_RS01475	COG0494	nUDIX hydrolase
A4G20_RS01485	COG2091	lysine biosynthetic process via aminoadipic acid
A4G20_RS01515	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A4G20_RS01520	COG1114	Component of the transport system for branched-chain amino acids
A4G20_RS01530	COG0483	inositol monophosphate 1-phosphatase activity
A4G20_RS01555	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A4G20_RS01570	COG4137	Cytochrome C assembly protein
A4G20_RS01580	COG2249	NAD(P)H dehydrogenase (quinone) activity
A4G20_RS01585	COG3312	ion transport
A4G20_RS01590	COG0356	it plays a direct role in the translocation of protons across the membrane
A4G20_RS01600	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A4G20_RS01615	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A4G20_RS01625	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A4G20_RS01630	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A4G20_RS01635	COG3062	negative regulation of establishment of protein localization
A4G20_RS01645	COG0437	4 iron, 4 sulfur cluster binding
A4G20_RS01650	COG0348	domain, Protein
A4G20_RS01655	COG3043	anaerobic respiration
A4G20_RS01660	COG3005	denitrification pathway
A4G20_RS01675	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A4G20_RS01715	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A4G20_RS01735	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A4G20_RS01750	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A4G20_RS01755	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A4G20_RS01760	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
A4G20_RS01770	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A4G20_RS01780	COG3738	Protein conserved in bacteria
A4G20_RS01820	COG4575	ribosome binding
A4G20_RS01835	COG0762	integral membrane protein
A4G20_RS01850	COG0545	Peptidyl-prolyl cis-trans isomerase
A4G20_RS01860	COG0569	domain protein
A4G20_RS01890	COG3541	Predicted nucleotidyltransferase
A4G20_RS01900	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
A4G20_RS01905	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
A4G20_RS01915	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
A4G20_RS01920	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
A4G20_RS01925	COG0508	dehydrogenase complex catalyzes the overall conversion of
A4G20_RS01930	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A4G20_RS01950	COG0800	Aldolase
A4G20_RS01995	COG0625	glutathione transferase activity
A4G20_RS02000	COG2814	Major facilitator Superfamily
A4G20_RS02005	COG1858	cytochrome C peroxidase
A4G20_RS02015	COG2168	tRNA wobble position uridine thiolation
A4G20_RS02025	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
A4G20_RS02030	COG2964	Protein conserved in bacteria
A4G20_RS02035	COG0545	Peptidyl-prolyl cis-trans isomerase
A4G20_RS02040	COG2900	Belongs to the SlyX family
A4G20_RS02055	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A4G20_RS02060	COG0737	Belongs to the 5'-nucleotidase family
A4G20_RS02085	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A4G20_RS02090	COG0204	Acyl-transferase
A4G20_RS02150	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A4G20_RS02155	COG3161	chorismate lyase activity
A4G20_RS02160	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
A4G20_RS02165	COG0501	Belongs to the peptidase M48B family
A4G20_RS02180	COG0828	Belongs to the bacterial ribosomal protein bS21 family
A4G20_RS02220	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A4G20_RS02225	COG0443	Heat shock 70 kDa protein
A4G20_RS02245	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A4G20_RS02285	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A4G20_RS02290	COG3077	Addiction module antitoxin, RelB DinJ family
A4G20_RS02300	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A4G20_RS02315	COG4771	TonB-dependent receptor
A4G20_RS02320	COG1012	belongs to the aldehyde dehydrogenase family
A4G20_RS02335	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
A4G20_RS02345	COG1393	Belongs to the ArsC family
A4G20_RS02350	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
A4G20_RS02355	COG3276	selenocysteine insertion sequence binding
A4G20_RS02360	COG2999	glutathione oxidoreductase activity
A4G20_RS02365	COG1119	ATPase activity
A4G20_RS02370	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
A4G20_RS02375	COG5002	protein histidine kinase activity
A4G20_RS02380	COG0745	RESPONSE REGULATOR receiver
A4G20_RS02385	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A4G20_RS02390	COG0581	inorganic phosphate transmembrane transporter activity
A4G20_RS02400	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A4G20_RS02415	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A4G20_RS02455	COG3099	Belongs to the UPF0263 family
A4G20_RS02465	COG1162	GTPase activity
A4G20_RS02475	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A4G20_RS02485	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A4G20_RS02490	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A4G20_RS02495	COG2850	peptidyl-arginine hydroxylation
A4G20_RS02500	COG0230	Belongs to the bacterial ribosomal protein bL34 family
A4G20_RS02505	COG0594	ribonuclease P activity
A4G20_RS02515	COG0708	Exodeoxyribonuclease III
A4G20_RS02525	COG0592	DNA-directed DNA polymerase activity
A4G20_RS02530	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A4G20_RS02540	COG0281	malic enzyme
A4G20_RS02540	COG0280	phosphate acetyltransferase
A4G20_RS02545	COG0037	tRNA processing
A4G20_RS02555	COG1028	Short-chain dehydrogenase reductase Sdr
A4G20_RS02560	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A4G20_RS02565	COG2217	Heavy metal translocating P-type atpase
A4G20_RS02570	COG3042	response to heat
A4G20_RS02575	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A4G20_RS02580	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
A4G20_RS02585	COG1584	GPR1 FUN34 yaaH family protein
A4G20_RS02590	COG2032	superoxide dismutase activity
A4G20_RS02595	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
A4G20_RS02600	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
A4G20_RS02605	COG0477	Major facilitator Superfamily
A4G20_RS02615	COG0180	Tryptophanyl-tRNA synthetase
A4G20_RS02630	COG0716	FMN binding
A4G20_RS02635	COG2255	four-way junction helicase activity
A4G20_RS02640	COG2823	Periplasmic or secreted lipoprotein
A4G20_RS02645	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
A4G20_RS02650	COG0792	nuclease activity
A4G20_RS02660	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A4G20_RS02665	COG0268	Binds directly to 16S ribosomal RNA
A4G20_RS02670	COG0728	peptidoglycan biosynthetic process
A4G20_RS02680	COG0406	alpha-ribazole phosphatase activity
A4G20_RS02685	COG0564	pseudouridine synthase activity
A4G20_RS02690	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A4G20_RS02715	COG0512	Glutamine amidotransferase of anthranilate synthase
A4G20_RS02725	COG0859	PFAM glycosyl transferase family 9
A4G20_RS02730	COG2608	mercury ion transmembrane transporter activity
A4G20_RS02740	COG1305	Transglutaminase-like
A4G20_RS02745	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A4G20_RS02755	COG1040	competence protein
A4G20_RS02760	COG0561	phosphatase activity
A4G20_RS02770	COG3468	outer membrane autotransporter barrel domain protein
A4G20_RS02780	COG0471	metal ion transport
A4G20_RS02785	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A4G20_RS02790	COG0500	methyltransferase
A4G20_RS02805	COG0084	hydrolase, TatD family'
A4G20_RS02810	COG4232	protein-disulfide reductase activity
A4G20_RS02820	COG0475	glutathione-regulated potassium exporter activity
A4G20_RS02820	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A4G20_RS02825	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A4G20_RS02825	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A4G20_RS02830	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A4G20_RS02855	COG2249	NAD(P)H dehydrogenase (quinone) activity
A4G20_RS02865	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
A4G20_RS02870	COG1522	sequence-specific DNA binding
A4G20_RS02875	COG2502	aspartate--ammonia ligase
A4G20_RS02890	COG0019	diaminopimelate decarboxylase activity
A4G20_RS02900	COG4211	Belongs to the binding-protein-dependent transport system permease family
A4G20_RS02910	COG1879	ABC-type sugar transport system periplasmic component
A4G20_RS02920	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A4G20_RS02930	COG0632	four-way junction helicase activity
A4G20_RS02940	COG3978	acetolactate synthase activity
A4G20_RS02960	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
A4G20_RS02975	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A4G20_RS02980	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A4G20_RS02985	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A4G20_RS02990	COG0737	Belongs to the 5'-nucleotidase family
A4G20_RS03000	COG1399	metal-binding, possibly nucleic acid-binding protein
A4G20_RS03010	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A4G20_RS03015	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A4G20_RS03020	COG3045	CreA protein
A4G20_RS03025	COG3171	Protein conserved in bacteria
A4G20_RS03035	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A4G20_RS03055	COG0438	transferase activity, transferring glycosyl groups
A4G20_RS03060	COG1215	transferase activity, transferring glycosyl groups
A4G20_RS03070	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
A4G20_RS03075	COG1970	mechanosensitive ion channel activity
A4G20_RS03090	COG5413	integral membrane protein
A4G20_RS03100	COG0628	permease
A4G20_RS03110	COG0747	negative chemotaxis
A4G20_RS03120	COG3030	protein affecting phage T7 exclusion by the F plasmid
A4G20_RS03125	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4G20_RS03130	COG2824	Alkylphosphonate utilization operon protein PhnA
A4G20_RS03135	COG3012	SEC-C Motif Domain Protein
A4G20_RS03140	COG0174	glutamine synthetase
A4G20_RS03180	COG0527	aspartate kinase activity
A4G20_RS03180	COG0460	homoserine dehydrogenase
A4G20_RS03185	COG0083	homoserine kinase activity
A4G20_RS03195	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
A4G20_RS03200	COG1349	DNA-binding transcription factor activity
A4G20_RS03205	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A4G20_RS03220	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4G20_RS03220	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A4G20_RS03225	COG3715	PTS system
A4G20_RS03230	COG3716	PTS system mannose fructose sorbose family IID component
A4G20_RS03245	COG1408	metallophosphoesterase
A4G20_RS03275	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A4G20_RS03280	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A4G20_RS03290	COG3022	response to hydroperoxide
A4G20_RS03295	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A4G20_RS03315	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A4G20_RS03320	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
A4G20_RS03325	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
A4G20_RS03350	COG0575	Belongs to the CDS family
A4G20_RS03355	COG0750	zinc metalloprotease
A4G20_RS03370	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A4G20_RS03375	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A4G20_RS03395	COG1643	Atp-dependent helicase
A4G20_RS03400	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A4G20_RS03405	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
A4G20_RS03475	COG4172	Belongs to the ABC transporter superfamily
A4G20_RS03480	COG1114	Component of the transport system for branched-chain amino acids
A4G20_RS03485	COG1053	succinate dehydrogenase
A4G20_RS03490	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A4G20_RS03500	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
A4G20_RS03530	COG0732	type I restriction modification DNA specificity domain
A4G20_RS03535	COG1525	nuclease
A4G20_RS03540	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A4G20_RS03545	COG2195	Cleaves the N-terminal amino acid of tripeptides
A4G20_RS03550	COG1652	LysM domain
A4G20_RS03555	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A4G20_RS03565	COG3005	denitrification pathway
A4G20_RS03570	COG0243	molybdopterin cofactor binding
A4G20_RS03580	COG3085	chromosome segregation
A4G20_RS03590	COG1621	beta-fructofuranosidase activity
A4G20_RS03610	COG0385	Bile acid
A4G20_RS03620	COG1940	carbohydrate kinase activity
A4G20_RS03630	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A4G20_RS03655	COG1022	Amp-dependent synthetase and ligase
A4G20_RS03680	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
A4G20_RS03685	COG3477	response to acidic pH
A4G20_RS03700	COG2194	sulfuric ester hydrolase activity
A4G20_RS03705	COG0517	IMP dehydrogenase activity
A4G20_RS03705	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
A4G20_RS03715	COG0210	DNA helicase
A4G20_RS03720	COG0277	FAD linked oxidase domain protein
A4G20_RS03725	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A4G20_RS03730	COG2920	part of a sulfur-relay system
A4G20_RS03735	COG0670	Belongs to the BI1 family
A4G20_RS03740	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A4G20_RS03745	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A4G20_RS03750	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A4G20_RS03755	COG0673	inositol 2-dehydrogenase activity
A4G20_RS03760	COG0534	Mate efflux family protein
A4G20_RS03770	COG2965	DNA replication, synthesis of RNA primer
A4G20_RS03780	COG0359	binds to the 23S rRNA
A4G20_RS03790	COG1805	sodium ion transport
A4G20_RS03795	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
A4G20_RS03815	COG1477	protein flavinylation
A4G20_RS03820	COG2991	Protein conserved in bacteria
A4G20_RS03825	COG0494	nUDIX hydrolase
A4G20_RS03830	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
A4G20_RS03835	COG0802	atpase or kinase
A4G20_RS03840	COG1388	LysM domain
A4G20_RS03840	COG0860	N-Acetylmuramoyl-L-alanine amidase
A4G20_RS03845	COG3117	lipopolysaccharide transmembrane transporter activity
A4G20_RS03850	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
A4G20_RS03855	COG1137	ATPase activity
A4G20_RS03860	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4G20_RS03865	COG1660	Displays ATPase and GTPase activities
A4G20_RS03870	COG0747	negative chemotaxis
A4G20_RS03880	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A4G20_RS03885	COG0444	Belongs to the ABC transporter superfamily
A4G20_RS03890	COG4608	Belongs to the ABC transporter superfamily
A4G20_RS03900	COG1441	menaquinone biosynthetic process
A4G20_RS03905	COG1560	Kdo2-lipid A biosynthetic process
A4G20_RS03910	COG3056	Lipoprotein
A4G20_RS03915	COG0271	Belongs to the BolA IbaG family
A4G20_RS03930	COG1966	Carbon starvation protein
A4G20_RS03935	COG3381	protein complex oligomerization
A4G20_RS03940	COG0814	amino acid
A4G20_RS03945	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A4G20_RS03950	COG0772	Belongs to the SEDS family
A4G20_RS03955	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
A4G20_RS03960	COG4166	transmembrane transport
A4G20_RS03965	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A4G20_RS03970	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A4G20_RS03975	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A4G20_RS03985	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A4G20_RS03990	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A4G20_RS03995	COG2062	phosphohistidine phosphatase, SixA
A4G20_RS04000	COG0469	pyruvate kinase activity
A4G20_RS04005	COG0859	PFAM glycosyl transferase family 9
A4G20_RS04010	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A4G20_RS04015	COG4680	protein conserved in bacteria
A4G20_RS04025	COG0287	Prephenate dehydrogenase
A4G20_RS04025	COG1605	Chorismate mutase
A4G20_RS04035	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A4G20_RS04045	COG2814	Major facilitator Superfamily
A4G20_RS04050	COG1942	4-Oxalocrotonate Tautomerase
A4G20_RS04055	COG1794	racemase activity, acting on amino acids and derivatives
A4G20_RS04060	COG4545	Glutaredoxin-related protein
A4G20_RS04080	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
A4G20_RS04095	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A4G20_RS04100	COG2801	Transposase and inactivated derivatives
A4G20_RS04115	COG4178	(ABC) transporter
A4G20_RS04150	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A4G20_RS04155	COG0232	Belongs to the dGTPase family. Type 2 subfamily
A4G20_RS04160	COG1218	3'(2'),5'-bisphosphate nucleotidase
A4G20_RS04170	COG4172	Belongs to the ABC transporter superfamily
A4G20_RS04175	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A4G20_RS04180	COG0601	transmembrane transport
A4G20_RS04185	COG4166	transmembrane transport
A4G20_RS04190	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A4G20_RS04195	COG1368	sulfuric ester hydrolase activity
A4G20_RS04205	COG0194	GDP metabolic process
A4G20_RS04210	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A4G20_RS04215	COG0768	penicillin binding
A4G20_RS04220	COG3116	cell division
A4G20_RS04230	COG2927	DNA polymerase III (CHI subunit)
A4G20_RS04275	COG2391	methyltransferase activity
A4G20_RS04280	COG0425	Belongs to the sulfur carrier protein TusA family
A4G20_RS04285	COG2252	PERMEase
A4G20_RS04290	COG3115	cell septum assembly
A4G20_RS04300	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
A4G20_RS04325	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
A4G20_RS04335	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A4G20_RS04350	COG0471	metal ion transport
A4G20_RS04365	COG1177	transmembrane transport
A4G20_RS04370	COG1176	ABC-type spermidine putrescine transport system, permease component I
A4G20_RS04375	COG3842	ATPase activity
A4G20_RS04390	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A4G20_RS04395	COG0346	lactoylglutathione lyase activity
A4G20_RS04400	COG1476	TRANSCRIPTIONal
A4G20_RS04415	COG0443	Heat shock 70 kDa protein
A4G20_RS04420	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A4G20_RS04430	COG2911	Protein conserved in bacteria
A4G20_RS04440	COG0747	negative chemotaxis
A4G20_RS04445	COG0012	GTP binding
A4G20_RS04455	COG0187	DNA topoisomerase II activity
A4G20_RS04460	COG0052	Belongs to the universal ribosomal protein uS2 family
A4G20_RS04465	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A4G20_RS04470	COG0659	secondary active sulfate transmembrane transporter activity
A4G20_RS04485	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4G20_RS04495	COG1120	ATPase activity
A4G20_RS04510	COG3105	Protein conserved in bacteria
A4G20_RS04515	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A4G20_RS04520	COG0481	GTPase activity
A4G20_RS04550	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A4G20_RS04550	COG0301	tRNA thio-modification
A4G20_RS04560	COG1074	ATP-dependent DNA helicase activity
A4G20_RS04565	COG1074	ATP-dependent DNA helicase activity
A4G20_RS04570	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A4G20_RS04575	COG0512	Glutamine amidotransferase of anthranilate synthase
A4G20_RS04595	COG0625	glutathione transferase activity
A4G20_RS04600	COG0135	phosphoribosylanthranilate isomerase activity
A4G20_RS04600	COG0134	indole-3-glycerol-phosphate synthase activity
A4G20_RS04605	COG0778	Nitroreductase
A4G20_RS04610	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
A4G20_RS04620	COG0330	HflC and HflK could
A4G20_RS04625	COG0084	hydrolase, TatD family'
A4G20_RS04635	COG0552	protein localization to endoplasmic reticulum
A4G20_RS04640	COG0742	ribosomal rna small subunit methyltransferase
A4G20_RS04645	COG1216	Glycosyl transferase, family 2
A4G20_RS04650	COG1216	Glycosyl transferase, family 2
A4G20_RS04665	COG3306	glycosyltransferase involved in LPS biosynthesis
A4G20_RS04675	COG2244	polysaccharide biosynthetic process
A4G20_RS04685	COG1434	Gram-negative-bacterium-type cell wall biogenesis
A4G20_RS04695	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
A4G20_RS04695	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
A4G20_RS04705	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
A4G20_RS04705	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A4G20_RS04710	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A4G20_RS04715	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A4G20_RS04720	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A4G20_RS04725	COG0795	lipopolysaccharide-transporting ATPase activity
A4G20_RS04730	COG0795	lipopolysaccharide-transporting ATPase activity
A4G20_RS04735	COG1686	Belongs to the peptidase S11 family
A4G20_RS04745	COG0443	Heat shock 70 kDa protein
A4G20_RS04755	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A4G20_RS04765	COG1116	anion transmembrane transporter activity
A4G20_RS04780	COG1252	NADH dehydrogenase
A4G20_RS04790	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A4G20_RS04800	COG0748	coenzyme F420 binding
A4G20_RS04805	COG3721	Heme iron utilization protein
A4G20_RS04810	COG2333	competence protein COMEC
A4G20_RS04810	COG0658	competence protein
A4G20_RS04850	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
A4G20_RS04855	COG1027	Aspartate ammonia-lyase
A4G20_RS04910	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A4G20_RS04925	COG2822	iron ion transport
A4G20_RS04930	COG2837	iron assimilation
A4G20_RS04935	COG0672	)-iron permease
A4G20_RS04945	COG0037	tRNA processing
A4G20_RS04950	COG2252	PERMEase
A4G20_RS04955	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
A4G20_RS04965	COG2840	Smr protein MutS2
A4G20_RS04970	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A4G20_RS04975	COG0577	efflux transmembrane transporter activity
A4G20_RS04975	COG1136	(ABC) transporter
A4G20_RS04980	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
A4G20_RS05000	COG0405	Gamma-glutamyltransferase
A4G20_RS05035	COG0583	DNA-binding transcription factor activity
A4G20_RS05040	COG0697	spore germination
A4G20_RS05045	COG1846	Transcriptional regulator
A4G20_RS05060	COG2315	Protein conserved in bacteria
A4G20_RS05075	COG1846	Transcriptional regulator
A4G20_RS05085	COG4977	sequence-specific DNA binding
A4G20_RS05090	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
A4G20_RS05110	COG1785	Belongs to the alkaline phosphatase family
A4G20_RS05120	COG0583	DNA-binding transcription factor activity
A4G20_RS05125	COG1944	ATP diphosphatase activity
A4G20_RS05135	COG1561	YicC-like family, N-terminal region
A4G20_RS05140	COG0354	folic acid binding
A4G20_RS05145	COG1011	Hydrolase
A4G20_RS05160	COG1530	ribonuclease E activity
A4G20_RS05180	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A4G20_RS05190	COG1446	asparaginase
A4G20_RS05210	COG0613	PHP domain protein
A4G20_RS05225	COG0305	Participates in initiation and elongation during chromosome replication
A4G20_RS05230	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
A4G20_RS05235	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A4G20_RS05295	COG0640	Transcriptional regulator
A4G20_RS05310	COG3665	Urea carboxylase-associated protein
A4G20_RS05330	COG1199	ATP-dependent helicase activity
A4G20_RS05335	COG1380	Effector of murein hydrolase LrgA
A4G20_RS05340	COG1346	cytolysis
A4G20_RS05345	COG1132	(ABC) transporter
A4G20_RS05350	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A4G20_RS05360	COG0717	Belongs to the dCTP deaminase family
A4G20_RS05365	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A4G20_RS05370	COG4235	cytochrome complex assembly
A4G20_RS05370	COG3088	subunit of a heme lyase
A4G20_RS05385	COG1720	tRNA m6t6A37 methyltransferase activity
A4G20_RS05390	COG1575	Belongs to the MenA family. Type 1 subfamily
A4G20_RS05395	COG0490	domain, Protein
A4G20_RS05395	COG0471	metal ion transport
A4G20_RS05400	COG0786	glutamate:sodium symporter activity
A4G20_RS05405	COG0745	RESPONSE REGULATOR receiver
A4G20_RS05410	COG0642	Histidine kinase
A4G20_RS05415	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A4G20_RS05430	COG0567	Dehydrogenase, E1 component
A4G20_RS05435	COG0508	dehydrogenase complex catalyzes the overall conversion of
A4G20_RS05450	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A4G20_RS05455	COG0596	Alpha beta hydrolase
A4G20_RS05465	COG0318	PFAM AMP-dependent synthetase and ligase
A4G20_RS05480	COG3264	Mechanosensitive ion channel
A4G20_RS05480	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
A4G20_RS05485	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
A4G20_RS05495	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
A4G20_RS05510	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
A4G20_RS05515	COG3683	transport system, periplasmic component
A4G20_RS05525	COG0583	DNA-binding transcription factor activity
A4G20_RS05530	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A4G20_RS05535	COG0251	oxidation-reduction process
A4G20_RS05545	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
A4G20_RS05555	COG0058	SHG alpha-glucan phosphorylase activity
A4G20_RS05590	COG3423	Transcriptional regulator
A4G20_RS05595	COG2801	Transposase and inactivated derivatives
A4G20_RS05605	COG2842	Transposition protein
A4G20_RS05615	COG4396	Host-nuclease inhibitor protein Gam
A4G20_RS05635	COG4382	Mu-like prophage protein Gp16
A4G20_RS05660	COG3023	N-Acetylmuramoyl-L-alanine amidase
A4G20_RS05685	COG0640	Transcriptional regulator
A4G20_RS05710	COG5005	Phage virion morphogenesis
A4G20_RS05820	COG3392	D12 class N6 adenine-specific DNA methyltransferase
A4G20_RS05840	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
A4G20_RS05845	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
A4G20_RS05850	COG3023	N-Acetylmuramoyl-L-alanine amidase
A4G20_RS05855	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
A4G20_RS05860	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A4G20_RS05865	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A4G20_RS05875	COG0709	Synthesizes selenophosphate from selenide and ATP
A4G20_RS05880	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A4G20_RS05885	COG0564	pseudouridine synthase activity
A4G20_RS05890	COG4166	transmembrane transport
A4G20_RS05900	COG0444	Belongs to the ABC transporter superfamily
A4G20_RS05905	COG4608	Belongs to the ABC transporter superfamily
A4G20_RS05915	COG3083	sulfuric ester hydrolase activity
A4G20_RS05935	COG3077	Addiction module antitoxin, RelB DinJ family
A4G20_RS05940	COG2026	Addiction module toxin, RelE StbE family
A4G20_RS05945	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
A4G20_RS05950	COG5295	Hep Hag repeat protein
A4G20_RS05950	COG5295	Hep Hag repeat protein
A4G20_RS05960	COG0583	DNA-binding transcription factor activity
A4G20_RS05980	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A4G20_RS05985	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
A4G20_RS06000	COG0393	Putative heavy-metal-binding
A4G20_RS06005	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A4G20_RS06020	COG1823	symporter activity
A4G20_RS06030	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A4G20_RS06035	COG0730	response to heat
A4G20_RS06040	COG4166	transmembrane transport
A4G20_RS06050	COG1595	DNA-templated transcription, initiation
A4G20_RS06055	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
A4G20_RS06060	COG0589	response to stress
A4G20_RS06070	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
A4G20_RS06075	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A4G20_RS06080	COG1077	Cell shape determining protein MreB Mrl
A4G20_RS06085	COG1792	Involved in formation and maintenance of cell shape
A4G20_RS06090	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
A4G20_RS06095	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A4G20_RS06100	COG0084	hydrolase, TatD family'
A4G20_RS06105	COG0556	nucleotide-excision repair
A4G20_RS06145	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A4G20_RS06160	COG0753	catalase activity
A4G20_RS06165	COG4115	mRNA cleavage
A4G20_RS06170	COG2161	toxin-antitoxin pair type II binding
A4G20_RS06190	COG0058	SHG alpha-glucan phosphorylase activity
A4G20_RS06200	COG0456	acetyltransferase
A4G20_RS06205	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
A4G20_RS06215	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A4G20_RS06225	COG0697	spore germination
A4G20_RS06240	COG0527	aspartate kinase activity
A4G20_RS06250	COG1278	Cold shock
A4G20_RS06260	COG0783	Belongs to the Dps family
A4G20_RS06265	COG1760	l-serine dehydratase
A4G20_RS06270	COG3550	peptidyl-serine autophosphorylation
A4G20_RS06280	COG0215	cysteine-tRNA ligase activity
A4G20_RS06285	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A4G20_RS06290	COG0538	isocitrate dehydrogenase activity
A4G20_RS06295	COG0814	amino acid
A4G20_RS06300	COG3058	Necessary for formate dehydrogenase activity
A4G20_RS06305	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
A4G20_RS06310	COG0285	dihydrofolate synthase activity
A4G20_RS06315	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A4G20_RS06320	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A4G20_RS06325	COG1121	(ABC) transporter
A4G20_RS06345	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A4G20_RS06350	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A4G20_RS06355	COG0539	negative regulation of cytoplasmic translation
A4G20_RS06365	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
A4G20_RS06370	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
A4G20_RS06375	COG0284	orotidine-5'-phosphate decarboxylase activity
A4G20_RS06380	COG0023	Translation Initiation Factor
A4G20_RS06385	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
A4G20_RS06390	COG0741	lytic transglycosylase activity
A4G20_RS06395	COG1522	sequence-specific DNA binding
A4G20_RS06400	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A4G20_RS06415	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A4G20_RS06430	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A4G20_RS06435	COG4991	sh3 domain protein
A4G20_RS06440	COG0306	phosphate transporter
A4G20_RS06445	COG1392	Phosphate transport regulator
A4G20_RS06465	COG0791	NLP P60 protein
A4G20_RS06470	COG3026	antisigma factor binding
A4G20_RS06480	COG0625	glutathione transferase activity
A4G20_RS06485	COG2969	positive regulation of protein catabolic process
A4G20_RS06495	COG0318	PFAM AMP-dependent synthetase and ligase
A4G20_RS06505	COG1049	propionate catabolic process, 2-methylcitrate cycle
A4G20_RS06510	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
A4G20_RS06515	COG1448	Aminotransferase
A4G20_RS06520	COG0788	formyltetrahydrofolate deformylase activity
A4G20_RS06530	COG1757	Na H antiporter
A4G20_RS06535	COG1674	ftsk spoiiie
A4G20_RS06545	COG4804	nuclease activity
A4G20_RS06570	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A4G20_RS06580	COG1595	DNA-templated transcription, initiation
A4G20_RS06590	COG0425	Belongs to the sulfur carrier protein TusA family
A4G20_RS06590	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A4G20_RS06595	COG2363	Small membrane protein
A4G20_RS06615	COG0195	Participates in both transcription termination and antitermination
A4G20_RS06625	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A4G20_RS06630	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
A4G20_RS06635	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
A4G20_RS06645	COG0513	Belongs to the DEAD box helicase family
A4G20_RS06655	COG1509	lysine 2,3-aminomutase activity
A4G20_RS06660	COG4221	oxidoreductase activity
A4G20_RS06670	COG1024	Enoyl-CoA hydratase
A4G20_RS06670	COG1250	3-hydroxyacyl-CoA dehydrogenase
A4G20_RS06675	COG2354	Protein conserved in bacteria
A4G20_RS06680	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
A4G20_RS06695	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A4G20_RS06705	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A4G20_RS06710	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A4G20_RS06715	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
A4G20_RS06720	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
A4G20_RS06730	COG0435	Glutathione S-transferase
A4G20_RS06740	COG1846	Transcriptional regulator
A4G20_RS06755	COG2321	neutral zinc metallopeptidase
A4G20_RS06760	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A4G20_RS06775	COG0590	tRNA wobble adenosine to inosine editing
A4G20_RS06780	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
A4G20_RS06805	COG0732	type I restriction modification DNA specificity domain
A4G20_RS06810	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
A4G20_RS06815	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A4G20_RS06820	COG3422	double-strand break repair
A4G20_RS06840	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A4G20_RS06845	COG1737	Transcriptional regulator
A4G20_RS06850	COG2731	YhcH YjgK YiaL family protein
A4G20_RS06855	COG0312	modulator of DNA gyrase
A4G20_RS06870	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A4G20_RS06880	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A4G20_RS06895	COG0339	signal peptide processing
A4G20_RS06900	COG3069	C4-dicarboxylate transmembrane transporter activity
A4G20_RS06935	COG2925	Exonuclease
A4G20_RS06940	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A4G20_RS06950	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A4G20_RS06955	COG0617	tRNA 3'-terminal CCA addition
A4G20_RS06960	COG3945	hemerythrin HHE cation binding domain
A4G20_RS06970	COG5295	Hep Hag repeat protein
A4G20_RS06995	COG0616	signal peptide processing
A4G20_RS07000	COG1122	ATPase activity
A4G20_RS07035	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A4G20_RS07040	COG0583	DNA-binding transcription factor activity
A4G20_RS07045	COG3041	Addiction module toxin RelE StbE family
A4G20_RS07060	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A4G20_RS07060	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A4G20_RS07065	COG0697	spore germination
A4G20_RS07080	COG4149	molybdate abc transporter
A4G20_RS07085	COG0725	ABC transporter, periplasmic molybdate-binding protein
A4G20_RS07090	COG2005	Transcriptional regulator
A4G20_RS07125	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A4G20_RS07130	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
A4G20_RS07135	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A4G20_RS07140	COG0697	spore germination
A4G20_RS07145	COG2949	membrane
A4G20_RS07150	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
A4G20_RS07165	COG0314	molybdopterin synthase activity
A4G20_RS07170	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
A4G20_RS07195	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A4G20_RS07215	COG1444	tRNA N-acetyltransferase activity
A4G20_RS07220	COG2864	formate dehydrogenase
A4G20_RS07225	COG0437	4 iron, 4 sulfur cluster binding
A4G20_RS07245	COG0006	proline dipeptidase activity
A4G20_RS07250	COG3956	TIGRFAM MazG family protein
A4G20_RS07255	COG0745	RESPONSE REGULATOR receiver
A4G20_RS07260	COG2205	protein histidine kinase activity
A4G20_RS07265	COG0288	reversible hydration of carbon dioxide
A4G20_RS07275	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A4G20_RS07280	COG0295	cytidine deaminase activity
A4G20_RS07295	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A4G20_RS07300	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A4G20_RS07305	COG1309	transcriptional regulator
A4G20_RS07310	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A4G20_RS07335	COG1704	LemA family
A4G20_RS07350	COG3140	Belongs to the UPF0181 family
A4G20_RS07365	COG1840	ABC-type Fe3 transport system, periplasmic component
A4G20_RS07380	COG0729	surface antigen
A4G20_RS07385	COG2911	Protein conserved in bacteria
A4G20_RS07390	COG4988	ABC transporter
A4G20_RS07395	COG2951	lytic endotransglycosylase activity
A4G20_RS07400	COG0189	ligase activity
A4G20_RS07405	COG0778	Nitroreductase
A4G20_RS07410	COG1494	fructose-1,6-bisphosphatase
A4G20_RS07415	COG3077	Addiction module antitoxin, RelB DinJ family
A4G20_RS07450	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
A4G20_RS07455	COG2814	Major facilitator Superfamily
A4G20_RS07465	COG4942	peptidase
A4G20_RS07470	COG2861	carbohydrate metabolic process
A4G20_RS07490	COG1968	undecaprenyl-diphosphatase activity
A4G20_RS07500	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
A4G20_RS07505	COG0626	cystathionine gamma-synthase activity
A4G20_RS07525	COG1214	PFAM Peptidase M22, glycoprotease
A4G20_RS07530	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A4G20_RS07535	COG0187	DNA topoisomerase II activity
A4G20_RS07540	COG0537	adenosine 5'-monophosphoramidase activity
A4G20_RS07555	COG0300	oxidoreductase activity
A4G20_RS07560	COG0778	Nitroreductase
A4G20_RS07565	COG0616	signal peptide processing
A4G20_RS07580	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A4G20_RS07585	COG2915	High frequency lysogenization protein hflD homolog
A4G20_RS07615	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A4G20_RS07625	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A4G20_RS07630	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A4G20_RS07635	COG1131	(ABC) transporter
A4G20_RS07640	COG0842	Transport permease protein
A4G20_RS07645	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
A4G20_RS07665	COG4143	(ABC) transporter
A4G20_RS07670	COG0402	S-adenosylhomocysteine deaminase activity
A4G20_RS07680	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A4G20_RS07715	COG2975	iron-sulfur cluster assembly
A4G20_RS07720	COG0633	Ferredoxin
A4G20_RS07760	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
A4G20_RS07765	COG0316	Belongs to the HesB IscA family
A4G20_RS07770	COG0822	iron-sulfur transferase activity
A4G20_RS07780	COG1959	2 iron, 2 sulfur cluster binding
A4G20_RS07790	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
A4G20_RS07800	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
A4G20_RS07800	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A4G20_RS07800	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A4G20_RS07805	COG1105	Belongs to the carbohydrate kinase PfkB family
A4G20_RS07810	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4G20_RS07810	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4G20_RS07820	COG1523	belongs to the glycosyl hydrolase 13 family
A4G20_RS07825	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
A4G20_RS07835	COG4172	Belongs to the ABC transporter superfamily
A4G20_RS07840	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A4G20_RS07845	COG0601	transmembrane transport
A4G20_RS07850	COG0747	negative chemotaxis
A4G20_RS07855	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A4G20_RS07860	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A4G20_RS07865	COG1560	Kdo2-lipid A biosynthetic process
A4G20_RS07875	COG0671	phosphoesterase, PA-phosphatase related
A4G20_RS07880	COG1534	Rna-binding protein
A4G20_RS07895	COG0857	belongs to the CobB CobQ family
A4G20_RS07895	COG0280	phosphate acetyltransferase
A4G20_RS07905	COG3025	triphosphatase activity
A4G20_RS07910	COG3106	COG3106 Predicted ATPase
A4G20_RS07920	COG4604	ABC transporter, ATP-binding protein
A4G20_RS07925	COG4605	iron ion homeostasis
A4G20_RS07930	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4G20_RS07935	COG4607	ABC-type enterochelin transport system periplasmic component
A4G20_RS07940	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A4G20_RS07970	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
A4G20_RS07975	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A4G20_RS07975	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
A4G20_RS07985	COG1702	phosphate starvation-inducible protein PhoH
A4G20_RS08000	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
A4G20_RS08015	COG2431	L-lysine efflux transmembrane transporter activity
A4G20_RS08020	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A4G20_RS08030	COG0497	DNA recombination
A4G20_RS08035	COG1138	Cytochrome C-type biogenesis protein
A4G20_RS08040	COG3301	Polysulphide reductase, NrfD
A4G20_RS08045	COG0437	4 iron, 4 sulfur cluster binding
A4G20_RS08050	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
A4G20_RS08070	COG0656	L-ascorbic acid biosynthetic process
A4G20_RS08075	COG0667	Aldo Keto reductase
A4G20_RS08080	COG0440	acetolactate synthase activity
A4G20_RS08085	COG0028	Belongs to the TPP enzyme family
A4G20_RS08095	COG0217	transcriptional regulatory protein
A4G20_RS08100	COG0494	nUDIX hydrolase
A4G20_RS08155	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A4G20_RS08160	COG2814	Major facilitator Superfamily
A4G20_RS08180	COG1187	pseudouridine synthase activity
A4G20_RS08185	COG0009	L-threonylcarbamoyladenylate synthase
A4G20_RS08190	COG2183	response to ionizing radiation
A4G20_RS08200	COG3036	rescue of stalled ribosome
A4G20_RS08205	COG2226	methyltransferase
A4G20_RS08220	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A4G20_RS08225	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A4G20_RS08230	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
A4G20_RS08235	COG0848	biopolymer transport protein
A4G20_RS08265	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
A4G20_RS08270	COG3283	Transcriptional regulator of aromatic amino acids metabolism
A4G20_RS08275	COG4166	transmembrane transport
A4G20_RS08280	COG4168	peptide transport system, permease
A4G20_RS08285	COG4171	peptide transport system, permease
A4G20_RS08290	COG4172	Belongs to the ABC transporter superfamily
A4G20_RS08300	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A4G20_RS08305	COG0516	GMP reductase activity
A4G20_RS08305	COG0517	IMP dehydrogenase activity
A4G20_RS08315	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A4G20_RS08340	COG0077	Prephenate dehydratase
A4G20_RS08340	COG1605	Chorismate mutase
A4G20_RS08350	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
A4G20_RS08355	COG1115	amino acid carrier protein
A4G20_RS08370	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A4G20_RS08380	COG1253	flavin adenine dinucleotide binding
A4G20_RS08385	COG4591	ABC-type transport system involved in lipoprotein release permease component
A4G20_RS08395	COG3547	Transposase (IS116 IS110 IS902 family)
A4G20_RS08420	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A4G20_RS08430	COG1045	serine acetyltransferase
A4G20_RS08440	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
A4G20_RS08445	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
A4G20_RS08450	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
A4G20_RS08455	COG1278	Cold shock
A4G20_RS08460	COG0433	COG0433 Predicted ATPase
A4G20_RS08465	COG2835	tetraacyldisaccharide 4'-kinase activity
A4G20_RS08470	COG1663	tetraacyldisaccharide 4'-kinase activity
A4G20_RS08475	COG2184	nucleotidyltransferase activity
A4G20_RS08485	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A4G20_RS08490	COG0740	serine-type endopeptidase activity
A4G20_RS08500	COG0631	protein serine/threonine phosphatase activity
A4G20_RS08540	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A4G20_RS08550	COG3924	membrane
A4G20_RS08555	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
A4G20_RS08560	COG2853	Lipoprotein
A4G20_RS08565	COG0676	glucose-6-phosphate 1-epimerase activity
A4G20_RS08570	COG1929	Belongs to the glycerate kinase type-1 family
A4G20_RS08575	COG2610	gluconate transmembrane transporter activity
A4G20_RS08580	COG1538	Outer membrane efflux protein
A4G20_RS08600	COG0560	Phosphoserine phosphatase
A4G20_RS08610	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A4G20_RS08630	COG0251	oxidation-reduction process
A4G20_RS08635	COG0121	glutamine amidotransferase
A4G20_RS08640	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A4G20_RS08645	COG1121	(ABC) transporter
A4G20_RS08650	COG0739	heme binding
A4G20_RS08655	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A4G20_RS08660	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A4G20_RS08670	COG0561	phosphatase activity
A4G20_RS08675	COG3850	Histidine kinase
A4G20_RS08685	COG1126	abc transporter atp-binding protein
A4G20_RS08690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4G20_RS08695	COG4215	(ABC) transporter
A4G20_RS08700	COG4160	amino acid transport
A4G20_RS08710	COG2350	Protein conserved in bacteria
A4G20_RS08730	COG3092	negative regulation of chromosome organization
A4G20_RS08735	COG2814	Major facilitator Superfamily
A4G20_RS08750	COG3068	Protein conserved in bacteria
A4G20_RS08760	COG0492	ferredoxin-NADP+ reductase activity
A4G20_RS08770	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
A4G20_RS08780	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A4G20_RS08795	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
A4G20_RS08800	COG1466	dna polymerase III delta subunit
A4G20_RS08805	COG1476	TRANSCRIPTIONal
A4G20_RS08815	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A4G20_RS08820	COG0163	prenyltransferase activity
A4G20_RS08825	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A4G20_RS08830	COG1286	toxin biosynthetic process
A4G20_RS08835	COG0328	RNA-DNA hybrid ribonuclease activity
A4G20_RS08840	COG0586	Pfam SNARE associated Golgi protein
A4G20_RS08850	COG0167	dihydroorotate dehydrogenase activity
A4G20_RS08855	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A4G20_RS08860	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
A4G20_RS08870	COG4589	Belongs to the CDS family
A4G20_RS08885	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A4G20_RS08890	COG0629	single-stranded DNA binding
A4G20_RS08900	COG0823	Involved in the tonB-independent uptake of proteins
A4G20_RS08905	COG3064	Membrane
A4G20_RS08905	COG3064	Membrane
A4G20_RS08910	COG0848	biopolymer transport protein
A4G20_RS08915	COG0811	peptide transport
A4G20_RS08920	COG0824	Thioesterase
A4G20_RS08935	COG1294	oxidase, subunit
A4G20_RS08940	COG1271	oxidase subunit
A4G20_RS08950	COG0681	Belongs to the peptidase S26 family
A4G20_RS08960	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A4G20_RS08970	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A4G20_RS08975	COG0564	pseudouridine synthase activity
A4G20_RS08980	COG3098	single-species biofilm formation
A4G20_RS09015	COG2259	Doxx family
A4G20_RS09030	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A4G20_RS09035	COG2050	protein possibly involved in aromatic compounds catabolism
A4G20_RS09040	COG0210	DNA helicase
A4G20_RS09045	COG1640	4-alpha-glucanotransferase
A4G20_RS09050	COG3833	ABC-type maltose transport systems, permease component
A4G20_RS09055	COG1175	transmembrane transport
A4G20_RS09060	COG2182	Extracellular solute-binding protein
A4G20_RS09075	COG3842	ATPase activity
A4G20_RS09080	COG2909	trisaccharide binding
A4G20_RS09090	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
A4G20_RS09110	COG3172	ATPase kinase involved in NAD metabolism
A4G20_RS09115	COG2129	metallophosphoesterase
A4G20_RS09130	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
A4G20_RS09135	COG0237	dephospho-CoA kinase activity
A4G20_RS09140	COG1476	TRANSCRIPTIONal
A4G20_RS09170	COG1459	type II secretion system
A4G20_RS09180	COG4969	Belongs to the N-Me-Phe pilin family
A4G20_RS09185	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
A4G20_RS09190	COG2095	MarC family integral membrane protein
A4G20_RS09195	COG4166	transmembrane transport
A4G20_RS09200	COG0489	protein tyrosine kinase activity
A4G20_RS09215	COG1519	Transferase
A4G20_RS09220	COG3307	-O-antigen
A4G20_RS09225	COG0733	neurotransmitter:sodium symporter activity
A4G20_RS09230	COG0338	D12 class N6 adenine-specific DNA methyltransferase
A4G20_RS09235	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A4G20_RS09240	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A4G20_RS09245	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
A4G20_RS09255	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A4G20_RS09260	COG1349	DNA-binding transcription factor activity
A4G20_RS09265	COG2222	sugar isomerase
A4G20_RS09270	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A4G20_RS09275	COG3715	PTS system
A4G20_RS09280	COG3716	PTS system mannose fructose sorbose family IID component
A4G20_RS09285	COG0546	phosphoglycolate phosphatase activity
A4G20_RS09305	COG3684	Belongs to the aldolase LacD family
A4G20_RS09310	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
A4G20_RS09325	COG4795	General secretion pathway protein
A4G20_RS09335	COG0598	Magnesium transport protein CorA
A4G20_RS09345	COG0138	bifunctional purine biosynthesis protein purh
A4G20_RS09350	COG4591	ABC-type transport system involved in lipoprotein release permease component
A4G20_RS09355	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A4G20_RS09365	COG2197	response regulator
A4G20_RS09370	COG3111	PFAM Bacterial OB fold (BOF) protein
A4G20_RS09380	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A4G20_RS09395	COG0583	DNA-binding transcription factor activity
A4G20_RS09425	COG1373	ATPase (AAA superfamily
A4G20_RS09440	COG1946	Acyl-CoA thioesterase
A4G20_RS09445	COG0745	RESPONSE REGULATOR receiver
A4G20_RS09450	COG4558	Periplasmic binding protein
A4G20_RS09455	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4G20_RS09460	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
A4G20_RS09465	COG1487	ribonuclease activity
A4G20_RS09480	COG2271	Major facilitator Superfamily
A4G20_RS09485	COG0584	glycerophosphoryl diester phosphodiesterase
A4G20_RS09490	COG0494	nUDIX hydrolase
A4G20_RS09510	COG0010	Belongs to the arginase family
A4G20_RS09525	COG0778	Nitroreductase
A4G20_RS09530	COG1169	isochorismate synthase
A4G20_RS09535	COG0436	Aminotransferase
A4G20_RS09545	COG2962	Rard protein
A4G20_RS09550	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A4G20_RS09560	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
A4G20_RS09570	COG1085	galactose-1-phosphate uridylyltransferase
A4G20_RS09575	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
A4G20_RS09580	COG2017	converts alpha-aldose to the beta-anomer
A4G20_RS09585	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
A4G20_RS09590	COG0793	Belongs to the peptidase S41A family
A4G20_RS09595	COG2989	Protein conserved in bacteria
A4G20_RS09600	COG3108	Peptidase M15
A4G20_RS09605	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A4G20_RS09610	COG1127	ABC transporter
A4G20_RS09615	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A4G20_RS09620	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A4G20_RS09625	COG2854	intermembrane phospholipid transfer
A4G20_RS09635	COG5007	Belongs to the BolA IbaG family
A4G20_RS09645	COG2177	Part of the ABC transporter FtsEX involved in
A4G20_RS09650	COG2884	Cell division ATP-binding protein ftsE
A4G20_RS09655	COG3118	belongs to the thioredoxin family
A4G20_RS09660	COG0142	geranyltranstransferase activity
A4G20_RS09665	COG1722	exodeoxyribonuclease VII activity
A4G20_RS09670	COG0633	Ferredoxin
A4G20_RS09670	COG3217	Mosc domain protein beta barrel domain protein
A4G20_RS09675	COG0482	sulfurtransferase activity
A4G20_RS09695	COG3015	lipoprotein NlpE involved in copper resistance
A4G20_RS09700	COG1238	metal cluster binding
A4G20_RS09750	COG2226	methyltransferase
A4G20_RS09765	COG3201	nicotinamide mononucleotide transporter
A4G20_RS09770	COG2976	Protein conserved in bacteria
A4G20_RS09780	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
A4G20_RS09785	COG1426	Protein conserved in bacteria
A4G20_RS09790	COG3842	ATPase activity
A4G20_RS09805	COG0475	glutathione-regulated potassium exporter activity
A4G20_RS09805	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A4G20_RS09810	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A4G20_RS09815	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A4G20_RS09820	COG1862	Preprotein translocase
A4G20_RS09825	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
A4G20_RS09835	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A4G20_RS09840	COG2223	nitrite transmembrane transporter activity
A4G20_RS09850	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A4G20_RS09855	COG0159	tryptophan synthase activity
A4G20_RS09860	COG0133	tryptophan synthase activity
A4G20_RS09865	COG3118	belongs to the thioredoxin family
A4G20_RS09880	COG1090	epimerase
A4G20_RS09890	COG3719	Belongs to the RNase T2 family
A4G20_RS09895	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A4G20_RS09900	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A4G20_RS09920	COG0196	riboflavin kinase activity
A4G20_RS09930	COG4804	nuclease activity
A4G20_RS09935	COG1678	Uncharacterized ACR, COG1678
A4G20_RS09950	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A4G20_RS09965	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
A4G20_RS09975	COG0181	hydroxymethylbilane synthase activity
A4G20_RS09985	COG2959	enzyme of heme biosynthesis
A4G20_RS09990	COG3071	HemY protein
A4G20_RS10000	COG0330	HflC and HflK could
A4G20_RS10005	COG0330	HflC and HflK could
A4G20_RS10010	COG0542	response to heat
A4G20_RS10015	COG1012	belongs to the aldehyde dehydrogenase family
A4G20_RS10045	COG0076	glutamate decarboxylase activity
A4G20_RS10050	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A4G20_RS10055	COG0439	Biotin carboxylase
A4G20_RS10060	COG0511	ligase activity, forming carbon-carbon bonds
A4G20_RS10065	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A4G20_RS10080	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A4G20_RS10090	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A4G20_RS10095	COG3119	arylsulfatase activity
A4G20_RS10125	COG0641	radical SAM
A4G20_RS10140	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A4G20_RS10145	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A4G20_RS10150	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
A4G20_RS10155	COG2731	YhcH YjgK YiaL family protein
A4G20_RS10165	COG1414	Transcriptional regulator
A4G20_RS10175	COG1138	Cytochrome C-type biogenesis protein
A4G20_RS10185	COG0191	fructose-bisphosphate aldolase activity
A4G20_RS10195	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
A4G20_RS10200	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A4G20_RS10205	COG0544	peptidyl-prolyl cis-trans isomerase activity
A4G20_RS10210	COG4221	oxidoreductase activity
A4G20_RS10225	COG1373	ATPase (AAA superfamily
A4G20_RS10240	COG0470	DNA polymerase III
A4G20_RS10245	COG3101	peptidyl-lysine hydroxylation
A4G20_RS10250	COG0142	geranyltranstransferase activity
A4G20_RS10255	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
A4G20_RS10260	COG1178	ABC-type Fe3 transport system permease component
A4G20_RS10265	COG1620	l-lactate permease
A4G20_RS10270	COG0247	lactate metabolic process
A4G20_RS10280	COG1556	Lactate utilization protein
A4G20_RS10305	COG0321	lipoyl(octanoyl) transferase activity
A4G20_RS10325	COG3590	peptidase
A4G20_RS10330	COG2226	methyltransferase
A4G20_RS10335	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
A4G20_RS10340	COG4972	Pilus assembly protein
A4G20_RS10360	COG4796	Type ii and iii secretion system protein
A4G20_RS10365	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A4G20_RS10370	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
A4G20_RS10375	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
A4G20_RS10380	COG1280	lysine exporter protein (LysE YggA)
A4G20_RS10385	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A4G20_RS10390	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A4G20_RS10400	COG2364	Membrane
A4G20_RS10415	COG0716	FMN binding
A4G20_RS10420	COG0735	belongs to the Fur family
A4G20_RS10425	COG3008	intermembrane lipid transfer
A4G20_RS10430	COG1854	S-ribosylhomocysteine lyase activity
A4G20_RS10435	COG1132	(ABC) transporter
A4G20_RS10440	COG0463	Glycosyl transferase, family 2
A4G20_RS10445	COG0438	transferase activity, transferring glycosyl groups
A4G20_RS10455	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
A4G20_RS10460	COG2081	HI0933 family
A4G20_RS10470	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A4G20_RS10475	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A4G20_RS10480	COG0352	thiamine-phosphate diphosphorylase activity
A4G20_RS10510	COG0585	pseudouridine synthase activity
A4G20_RS10515	COG2818	Glycosylase
A4G20_RS10520	COG4942	peptidase
A4G20_RS10520	COG1388	LysM domain
A4G20_RS10530	COG1238	metal cluster binding
A4G20_RS10535	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
A4G20_RS10545	COG0730	response to heat
A4G20_RS10555	COG2166	iron-sulfur cluster assembly
A4G20_RS10560	COG2095	MarC family integral membrane protein
A4G20_RS10570	COG2814	Major facilitator Superfamily
A4G20_RS10605	COG0815	Transfers the fatty acyl group on membrane lipoproteins
A4G20_RS10615	COG2932	Transcriptional regulator
A4G20_RS10635	COG1028	Short-chain dehydrogenase reductase Sdr
A4G20_RS10645	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A4G20_RS10710	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A4G20_RS10715	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A4G20_RS10740	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A4G20_RS10755	COG1131	(ABC) transporter
A4G20_RS10760	COG0842	Transport permease protein
A4G20_RS10805	COG2608	mercury ion transmembrane transporter activity
A4G20_RS10810	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A4G20_RS10820	COG1181	Belongs to the D-alanine--D-alanine ligase family
A4G20_RS10835	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A4G20_RS10840	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
A4G20_RS10845	COG1115	amino acid carrier protein
A4G20_RS10890	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A4G20_RS10910	COG2137	regulation of response to DNA damage stimulus
A4G20_RS10935	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
A4G20_RS10940	COG0316	Belongs to the HesB IscA family
A4G20_RS10945	COG1126	abc transporter atp-binding protein
A4G20_RS10950	COG0765	amino acid transport
A4G20_RS10955	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4G20_RS10965	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A4G20_RS10975	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
A4G20_RS10995	COG1530	ribonuclease E activity
A4G20_RS11000	COG0733	neurotransmitter:sodium symporter activity
A4G20_RS11010	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A4G20_RS11020	COG1309	transcriptional regulator
A4G20_RS11030	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A4G20_RS11035	COG1490	D-aminoacyl-tRNA deacylase activity
A4G20_RS11045	COG3545	Serine hydrolase
A4G20_RS11060	COG0246	Mannitol dehydrogenase
A4G20_RS11065	COG3722	fumarate hydratase activity
A4G20_RS11070	COG1289	transmembrane transporter activity
A4G20_RS11075	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A4G20_RS11090	COG0814	amino acid
A4G20_RS11095	COG0335	large ribosomal subunit rRNA binding
A4G20_RS11100	COG0336	Belongs to the RNA methyltransferase TrmD family