locus-tag	class	description
F8M42_RS00010	COG0592	DNA-directed DNA polymerase activity
F8M42_RS00035	COG0045	succinate-CoA ligase (ADP-forming) activity
F8M42_RS00040	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
F8M42_RS00045	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
F8M42_RS00060	COG0183	Belongs to the thiolase family
F8M42_RS00075	COG3254	rhamnose metabolic process
F8M42_RS00080	COG2814	Major facilitator Superfamily
F8M42_RS00085	COG0235	Class ii aldolase
F8M42_RS00090	COG4806	L-rhamnose isomerase
F8M42_RS00095	COG1070	Carbohydrate kinase
F8M42_RS00100	COG1349	DNA-binding transcription factor activity
F8M42_RS00110	COG0583	DNA-binding transcription factor activity
F8M42_RS00120	COG1132	(ABC) transporter
F8M42_RS00125	COG1968	undecaprenyl-diphosphatase activity
F8M42_RS00130	COG1773	rubredoxin
F8M42_RS00130	COG1592	Rubrerythrin
F8M42_RS00140	COG0716	FMN binding
F8M42_RS00155	COG0840	transmembrane signaling receptor activity
F8M42_RS00160	COG1606	tRNA processing
F8M42_RS00170	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
F8M42_RS00175	COG0505	Belongs to the CarA family
F8M42_RS00180	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
F8M42_RS00185	COG0540	Belongs to the ATCase OTCase family
F8M42_RS00195	COG0237	dephospho-CoA kinase activity
F8M42_RS00200	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
F8M42_RS00205	COG0583	DNA-binding transcription factor activity
F8M42_RS00235	COG3775	system Galactitol-specific IIC component
F8M42_RS00240	COG3414	Phosphotransferase system galactitol-specific IIB component
F8M42_RS00250	COG3711	transcriptional antiterminator
F8M42_RS00250	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
F8M42_RS00270	COG1686	Belongs to the peptidase S11 family
F8M42_RS00280	COG5002	protein histidine kinase activity
F8M42_RS00285	COG0745	RESPONSE REGULATOR receiver
F8M42_RS00295	COG3118	belongs to the thioredoxin family
F8M42_RS00300	COG0492	ferredoxin-NADP+ reductase activity
F8M42_RS00305	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
F8M42_RS00310	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
F8M42_RS00320	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
F8M42_RS00325	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
F8M42_RS00340	COG1271	oxidase subunit
F8M42_RS00345	COG1294	oxidase, subunit
F8M42_RS00350	COG4988	ABC transporter
F8M42_RS00355	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
F8M42_RS00380	COG0813	purine-nucleoside phosphorylase activity
F8M42_RS00390	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
F8M42_RS00420	COG1737	Transcriptional regulator
F8M42_RS00440	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F8M42_RS00455	COG1063	alcohol dehydrogenase
F8M42_RS00460	COG1028	Short-chain dehydrogenase reductase Sdr
F8M42_RS00470	COG2391	methyltransferase activity
F8M42_RS00475	COG0425	Belongs to the sulfur carrier protein TusA family
F8M42_RS00475	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F8M42_RS00480	COG2391	methyltransferase activity
F8M42_RS00490	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
F8M42_RS00505	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
F8M42_RS00520	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
F8M42_RS00525	COG1088	dTDP-glucose 4,6-dehydratase activity
F8M42_RS00530	COG0251	oxidation-reduction process
F8M42_RS00535	COG0351	phosphomethylpyrimidine kinase
F8M42_RS00545	COG0849	cell division
F8M42_RS00555	COG1074	ATP-dependent DNA helicase activity
F8M42_RS00560	COG0673	inositol 2-dehydrogenase activity
F8M42_RS00565	COG0439	Biotin carboxylase
F8M42_RS00570	COG1597	lipid kinase activity
F8M42_RS00575	COG2244	polysaccharide biosynthetic process
F8M42_RS00585	COG1555	photosystem II stabilization
F8M42_RS00585	COG1596	polysaccharide export
F8M42_RS00590	COG0658	competence protein
F8M42_RS00590	COG2333	competence protein COMEC
F8M42_RS00600	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
F8M42_RS00605	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
F8M42_RS00610	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
F8M42_RS00620	COG0739	heme binding
F8M42_RS00630	COG0069	glutamate synthase activity
F8M42_RS00635	COG0493	'glutamate synthase
F8M42_RS00645	COG2271	Major facilitator Superfamily
F8M42_RS00655	COG1285	pathogenesis
F8M42_RS00670	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
F8M42_RS00675	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F8M42_RS00675	COG1263	PTS System
F8M42_RS00680	COG0363	glucosamine-6-phosphate deaminase activity
F8M42_RS00690	COG2190	(PTS) system
F8M42_RS00690	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F8M42_RS00690	COG1263	PTS System
F8M42_RS00695	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
F8M42_RS00705	COG0113	porphobilinogen synthase activity
F8M42_RS00715	COG0765	amino acid transport
F8M42_RS00730	COG0181	hydroxymethylbilane synthase activity
F8M42_RS00735	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
F8M42_RS00740	COG1648	precorrin-2 dehydrogenase activity
F8M42_RS00740	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
F8M42_RS00745	COG1461	Dihydroxyacetone kinase
F8M42_RS00765	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
F8M42_RS00790	COG0714	Associated with various cellular activities
F8M42_RS00800	COG1305	Transglutaminase-like
F8M42_RS00805	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
F8M42_RS00815	COG3328	transposase activity
F8M42_RS00830	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F8M42_RS00840	COG1850	ribulose-bisphosphate carboxylase activity
F8M42_RS00845	COG3775	system Galactitol-specific IIC component
F8M42_RS00850	COG3414	Phosphotransferase system galactitol-specific IIB component
F8M42_RS00860	COG3711	transcriptional antiterminator
F8M42_RS00860	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
F8M42_RS00875	COG3328	transposase activity
F8M42_RS00895	COG4120	Belongs to the binding-protein-dependent transport system permease family
F8M42_RS00925	COG3933	PFAM sigma-54 factor interaction domain-containing protein
F8M42_RS00925	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
F8M42_RS00935	COG3414	Phosphotransferase system galactitol-specific IIB component
F8M42_RS00940	COG3775	system Galactitol-specific IIC component
F8M42_RS00945	COG1063	alcohol dehydrogenase
F8M42_RS00950	COG0698	ribose 5-phosphate isomerase
F8M42_RS00955	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
F8M42_RS00970	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
F8M42_RS00975	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
F8M42_RS00980	COG0564	pseudouridine synthase activity
F8M42_RS00995	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
F8M42_RS01000	COG0586	Pfam SNARE associated Golgi protein
F8M42_RS01025	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
F8M42_RS01030	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F8M42_RS01035	COG1120	ATPase activity
F8M42_RS01040	COG1607	acyl-coa hydrolase
F8M42_RS01050	COG1914	H( )-stimulated, divalent metal cation uptake system
F8M42_RS01060	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
F8M42_RS01080	COG0840	transmembrane signaling receptor activity
F8M42_RS01110	COG1902	pentaerythritol trinitrate reductase activity
F8M42_RS01115	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
F8M42_RS01120	COG2309	aminopeptidase activity
F8M42_RS01130	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
F8M42_RS01150	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F8M42_RS01160	COG4336	lyase activity
F8M42_RS01165	COG0439	Biotin carboxylase
F8M42_RS01170	COG0511	ligase activity, forming carbon-carbon bonds
F8M42_RS01175	COG1984	allophanate hydrolase subunit 2
F8M42_RS01180	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
F8M42_RS01190	COG1914	H( )-stimulated, divalent metal cation uptake system
F8M42_RS01200	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
F8M42_RS01245	COG0791	NLP P60 protein
F8M42_RS01245	COG1388	LysM domain
F8M42_RS01250	COG0640	Transcriptional regulator
F8M42_RS01260	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
F8M42_RS01260	COG0512	Glutamine amidotransferase of anthranilate synthase
F8M42_RS01265	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
F8M42_RS01270	COG0134	indole-3-glycerol-phosphate synthase activity
F8M42_RS01275	COG0133	tryptophan synthase activity
F8M42_RS01280	COG0159	tryptophan synthase activity
F8M42_RS01300	COG0730	response to heat
F8M42_RS01305	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
F8M42_RS01310	COG0284	orotidine-5'-phosphate decarboxylase activity
F8M42_RS01315	COG0424	maF-like protein
F8M42_RS01330	COG3210	domain, Protein
F8M42_RS01335	COG3210	domain, Protein
F8M42_RS01335	COG3210	domain, Protein
F8M42_RS01360	COG5444	nuclease activity
F8M42_RS01375	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
F8M42_RS01400	COG1214	PFAM Peptidase M22, glycoprotease
F8M42_RS01415	COG2385	sporulation resulting in formation of a cellular spore
F8M42_RS01420	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
F8M42_RS01435	COG0246	Mannitol dehydrogenase
F8M42_RS01440	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
F8M42_RS01440	COG2213	PTS system mannitol-specific
F8M42_RS01445	COG3711	transcriptional antiterminator
F8M42_RS01450	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F8M42_RS01455	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
F8M42_RS01460	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
F8M42_RS01465	COG0589	response to stress
F8M42_RS01470	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
F8M42_RS01475	COG0629	single-stranded DNA binding
F8M42_RS01480	COG0360	Binds together with S18 to 16S ribosomal RNA
F8M42_RS01485	COG2814	Major facilitator Superfamily
F8M42_RS01505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F8M42_RS01510	COG0765	amino acid transport
F8M42_RS01515	COG1126	abc transporter atp-binding protein
F8M42_RS01520	COG1358	cellular component organization or biogenesis
F8M42_RS01525	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
F8M42_RS01530	COG0049	tRNA binding
F8M42_RS01535	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
F8M42_RS01540	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
F8M42_RS01550	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
F8M42_RS01555	COG0088	Forms part of the polypeptide exit tunnel
F8M42_RS01560	COG0089	rRNA binding
F8M42_RS01565	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
F8M42_RS01570	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
F8M42_RS01575	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
F8M42_RS01580	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
F8M42_RS01585	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
F8M42_RS01590	COG0255	Belongs to the universal ribosomal protein uL29 family
F8M42_RS01595	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
F8M42_RS01600	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
F8M42_RS01605	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
F8M42_RS01610	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
F8M42_RS01615	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
F8M42_RS01620	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
F8M42_RS01635	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
F8M42_RS01640	COG1841	ribosomal large subunit assembly
F8M42_RS01645	COG0200	Binds to the 23S rRNA
F8M42_RS01650	COG0201	protein transport
F8M42_RS01655	COG0563	adenylate kinase activity
F8M42_RS01665	COG0257	Belongs to the bacterial ribosomal protein bL36 family
F8M42_RS01670	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
F8M42_RS01675	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
F8M42_RS01680	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
F8M42_RS01685	COG0202	RNA polymerase activity
F8M42_RS01705	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
F8M42_RS01710	COG0719	Fe-S assembly protein
F8M42_RS01720	COG0396	ATPase activity
F8M42_RS01725	COG0039	L-malate dehydrogenase activity
F8M42_RS01730	COG1122	ATPase activity
F8M42_RS01740	COG1032	radical SAM domain protein
F8M42_RS01745	COG3933	PFAM sigma-54 factor interaction domain-containing protein
F8M42_RS01745	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
F8M42_RS01750	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
F8M42_RS01755	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F8M42_RS01765	COG3716	PTS system mannose fructose sorbose family IID component
F8M42_RS01770	COG0371	Dehydrogenase
F8M42_RS01775	COG0647	UMP catabolic process
F8M42_RS01780	COG0371	Dehydrogenase
F8M42_RS01795	COG3732	PTS system glucitol sorbitol-specific
F8M42_RS01810	COG1063	alcohol dehydrogenase
F8M42_RS01825	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
F8M42_RS01830	COG3775	system Galactitol-specific IIC component
F8M42_RS01835	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
F8M42_RS01835	COG3933	PFAM sigma-54 factor interaction domain-containing protein
F8M42_RS01840	COG1349	DNA-binding transcription factor activity
F8M42_RS01845	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
F8M42_RS01850	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
F8M42_RS01855	COG0698	ribose 5-phosphate isomerase
F8M42_RS01860	COG0191	fructose-bisphosphate aldolase activity
F8M42_RS01870	COG1122	ATPase activity
F8M42_RS01875	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
F8M42_RS01880	COG0101	tRNA pseudouridine synthase activity
F8M42_RS01905	COG0583	DNA-binding transcription factor activity
F8M42_RS01910	COG2894	cell division
F8M42_RS01920	COG1702	phosphate starvation-inducible protein PhoH
F8M42_RS01925	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
F8M42_RS01930	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
F8M42_RS01940	COG1381	Involved in DNA repair and RecF pathway recombination
F8M42_RS01960	COG0635	Involved in the biosynthesis of porphyrin-containing compound
F8M42_RS01975	COG0205	6-phosphofructokinase activity
F8M42_RS01985	COG2003	Belongs to the UPF0758 family
F8M42_RS01990	COG1077	Cell shape determining protein MreB Mrl
F8M42_RS01995	COG1792	Involved in formation and maintenance of cell shape
F8M42_RS02005	COG0768	penicillin binding
F8M42_RS02010	COG0850	regulation of cytokinetic process
F8M42_RS02015	COG2894	cell division
F8M42_RS02020	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
F8M42_RS02030	COG2255	four-way junction helicase activity
F8M42_RS02035	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
F8M42_RS02055	COG5434	Belongs to the glycosyl hydrolase 28 family
F8M42_RS02055	COG4632	Exopolysaccharide biosynthesis protein
F8M42_RS02065	COG5599	Phosphatase
F8M42_RS02080	COG4786	Flagellar basal body rod
F8M42_RS02095	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
F8M42_RS02100	COG1706	bacterial-type flagellum-dependent cell motility
F8M42_RS02125	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
F8M42_RS02130	COG1127	ABC transporter
F8M42_RS02150	COG1191	sigma factor activity
F8M42_RS02160	COG2831	hemolysin activation secretion protein
F8M42_RS02185	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
F8M42_RS02195	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
F8M42_RS02200	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
F8M42_RS02205	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
F8M42_RS02210	COG3494	Protein of unknown function (DUF1009)
F8M42_RS02215	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
F8M42_RS02220	COG1132	(ABC) transporter
F8M42_RS02225	COG1663	tetraacyldisaccharide 4'-kinase activity
F8M42_RS02230	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
F8M42_RS02235	COG2877	3-deoxy-8-phosphooctulonate synthase activity
F8M42_RS02245	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
F8M42_RS02265	COG1137	ATPase activity
F8M42_RS02275	COG4372	Transposase
F8M42_RS02285	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
F8M42_RS02295	COG4496	protein, YerC YecD
F8M42_RS02300	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
F8M42_RS02310	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
F8M42_RS02315	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
F8M42_RS02320	COG0131	Imidazoleglycerol-phosphate dehydratase
F8M42_RS02325	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
F8M42_RS02335	COG0107	imidazoleglycerol-phosphate synthase activity
F8M42_RS02340	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
F8M42_RS02340	COG0140	phosphoribosyl-ATP diphosphatase activity
F8M42_RS02355	COG0470	DNA polymerase III
F8M42_RS02360	COG1774	PSP1 C-terminal conserved region
F8M42_RS02365	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
F8M42_RS02370	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
F8M42_RS02375	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F8M42_RS02380	COG5433	transposase activity
F8M42_RS02385	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F8M42_RS02385	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F8M42_RS02390	COG0084	hydrolase, TatD family'
F8M42_RS02395	COG1388	LysM domain
F8M42_RS02395	COG3584	3D domain protein
F8M42_RS02405	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
F8M42_RS02410	COG0708	Exodeoxyribonuclease III
F8M42_RS02420	COG0077	Prephenate dehydratase
F8M42_RS02425	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
F8M42_RS02500	COG1857	crispr-associated protein
F8M42_RS02515	COG1518	maintenance of DNA repeat elements
F8M42_RS02555	COG1473	amidohydrolase
F8M42_RS02560	COG1619	proteins homologs of microcin C7 resistance protein MccF
F8M42_RS02565	COG0531	amino acid
F8M42_RS02570	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F8M42_RS02580	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
F8M42_RS02590	COG0482	sulfurtransferase activity
F8M42_RS02605	COG1433	Dinitrogenase iron-molybdenum cofactor
F8M42_RS02605	COG0535	radical SAM domain protein
F8M42_RS02615	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
F8M42_RS02625	COG2011	ABC-type metal ion transport system permease component
F8M42_RS02630	COG1464	Belongs to the NlpA lipoprotein family
F8M42_RS02655	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
F8M42_RS02665	COG1113	amino acid transport
F8M42_RS02670	COG0583	DNA-binding transcription factor activity
F8M42_RS02695	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
F8M42_RS02700	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
F8M42_RS02705	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
F8M42_RS02710	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
F8M42_RS02720	COG0247	lactate metabolic process
F8M42_RS02725	COG2376	Dihydroxyacetone kinase
F8M42_RS02730	COG1461	Dihydroxyacetone kinase
F8M42_RS02760	COG0375	protein maturation
F8M42_RS02775	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
F8M42_RS02780	COG0298	carbon dioxide binding
F8M42_RS02800	COG4221	oxidoreductase activity
F8M42_RS02805	COG3527	Alpha-acetolactate decarboxylase
F8M42_RS02810	COG0028	Belongs to the TPP enzyme family
F8M42_RS02815	COG0583	DNA-binding transcription factor activity
F8M42_RS02820	COG0531	amino acid
F8M42_RS02835	COG0583	DNA-binding transcription factor activity
F8M42_RS02845	COG2707	UPF0756 membrane protein
F8M42_RS02895	COG0726	polysaccharide deacetylase
F8M42_RS02920	COG1301	dicarboxylic acid transport
F8M42_RS02925	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F8M42_RS02935	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
F8M42_RS02940	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
F8M42_RS02945	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
F8M42_RS02950	COG3328	transposase activity
F8M42_RS02955	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
F8M42_RS02965	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
F8M42_RS02970	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
F8M42_RS02975	COG1994	Peptidase M50
F8M42_RS02980	COG0494	nUDIX hydrolase
F8M42_RS02985	COG0497	DNA recombination
F8M42_RS02995	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
F8M42_RS03000	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
F8M42_RS03005	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
F8M42_RS03010	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
F8M42_RS03020	COG1722	exodeoxyribonuclease VII activity
F8M42_RS03025	COG1570	exodeoxyribonuclease VII activity
F8M42_RS03030	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
F8M42_RS03045	COG1302	Protein conserved in bacteria
F8M42_RS03050	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
F8M42_RS03055	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
F8M42_RS03075	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
F8M42_RS03085	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
F8M42_RS03090	COG2814	Major facilitator Superfamily
F8M42_RS03100	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
F8M42_RS03115	COG2814	Major facilitator Superfamily
F8M42_RS03135	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
F8M42_RS03140	COG0346	lactoylglutathione lyase activity
F8M42_RS03145	COG0477	Major facilitator Superfamily
F8M42_RS03150	COG0583	DNA-binding transcription factor activity
F8M42_RS03170	COG0066	3-isopropylmalate dehydratase activity
F8M42_RS03175	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
F8M42_RS03180	COG0583	DNA-binding transcription factor activity
F8M42_RS03225	COG0356	it plays a direct role in the translocation of protons across the membrane
F8M42_RS03230	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
F8M42_RS03240	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
F8M42_RS03245	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
F8M42_RS03250	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
F8M42_RS03275	COG1309	transcriptional regulator
F8M42_RS03300	COG4895	conserved protein (DUF2196)
F8M42_RS03305	COG0561	phosphatase activity
F8M42_RS03310	COG3069	C4-dicarboxylate transmembrane transporter activity
F8M42_RS03315	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F8M42_RS03340	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F8M42_RS03345	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F8M42_RS03360	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
F8M42_RS03370	COG0626	cystathionine gamma-synthase activity
F8M42_RS03375	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
F8M42_RS03405	COG2873	o-acetylhomoserine
F8M42_RS03435	COG1136	(ABC) transporter
F8M42_RS03465	COG3706	GGDEF domain
F8M42_RS03500	COG0018	arginyl-trna synthetase
F8M42_RS03510	COG0504	CTP synthase activity
F8M42_RS03515	COG1253	flavin adenine dinucleotide binding
F8M42_RS03535	COG0544	peptidyl-prolyl cis-trans isomerase activity
F8M42_RS03540	COG0740	serine-type endopeptidase activity
F8M42_RS03545	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
F8M42_RS03550	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
F8M42_RS03570	COG0436	Aminotransferase
F8M42_RS03580	COG0653	protein targeting
F8M42_RS03625	COG2160	L-arabinose isomerase activity
F8M42_RS03645	COG3344	reverse transcriptase
F8M42_RS03650	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F8M42_RS03660	COG0765	amino acid transport
F8M42_RS03665	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
F8M42_RS03690	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F8M42_RS03700	COG4187	Peptidase family M20/M25/M40
F8M42_RS03705	COG1802	Transcriptional regulator
F8M42_RS03715	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F8M42_RS03720	COG0765	amino acid transport
F8M42_RS03725	COG1126	abc transporter atp-binding protein
F8M42_RS03735	COG0778	Nitroreductase
F8M42_RS03750	COG5002	protein histidine kinase activity
F8M42_RS03755	COG0704	Plays a role in the regulation of phosphate uptake
F8M42_RS03760	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
F8M42_RS03765	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
F8M42_RS03770	COG0248	Ppx GppA phosphatase
F8M42_RS03775	COG0745	RESPONSE REGULATOR receiver
F8M42_RS03780	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
F8M42_RS03785	COG0573	inorganic phosphate transmembrane transporter activity
F8M42_RS03790	COG0581	inorganic phosphate transmembrane transporter activity
F8M42_RS03795	COG0426	domain, Protein
F8M42_RS03805	COG0561	phosphatase activity
F8M42_RS03815	COG0488	(ABC) transporter
F8M42_RS03820	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
F8M42_RS03825	COG1040	competence protein
F8M42_RS03865	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
F8M42_RS03870	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
F8M42_RS03880	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
F8M42_RS03885	COG1516	flagellar protein fliS
F8M42_RS03900	COG0463	Glycosyl transferase, family 2
F8M42_RS03905	COG0463	Glycosyl transferase, family 2
F8M42_RS03905	COG0457	Tetratricopeptide repeat
F8M42_RS03915	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
F8M42_RS03925	COG0463	Glycosyl transferase, family 2
F8M42_RS03955	COG0028	Belongs to the TPP enzyme family
F8M42_RS03975	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
F8M42_RS03990	COG3328	transposase activity
F8M42_RS04045	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
F8M42_RS04050	COG3069	C4-dicarboxylate transmembrane transporter activity
F8M42_RS04055	COG4948	Mandelate Racemase Muconate Lactonizing
F8M42_RS04060	COG0583	DNA-binding transcription factor activity
F8M42_RS04105	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F8M42_RS04110	COG0800	Aldolase
F8M42_RS04115	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F8M42_RS04125	COG2169	Transcriptional regulator
F8M42_RS04130	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
F8M42_RS04135	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
F8M42_RS04145	COG2169	Transcriptional regulator
F8M42_RS04155	COG1473	amidohydrolase
F8M42_RS04160	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
F8M42_RS04180	COG0697	spore germination
F8M42_RS04185	COG0488	(ABC) transporter
F8M42_RS04190	COG1447	Phosphotransferase system cellobiose-specific component IIA
F8M42_RS04195	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
F8M42_RS04200	COG1122	ATPase activity
F8M42_RS04205	COG1122	ATPase activity
F8M42_RS04225	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
F8M42_RS04235	COG0347	Belongs to the P(II) protein family
F8M42_RS04270	COG1522	sequence-specific DNA binding
F8M42_RS04275	COG0778	Nitroreductase
F8M42_RS04280	COG4191	Histidine kinase
F8M42_RS04300	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F8M42_RS04305	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
F8M42_RS04350	COG0489	protein tyrosine kinase activity
F8M42_RS04350	COG3206	protein involved in exopolysaccharide biosynthesis
F8M42_RS04355	COG1450	Type ii and iii secretion system protein
F8M42_RS04385	COG0535	radical SAM domain protein
F8M42_RS04390	COG0535	radical SAM domain protein
F8M42_RS04395	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
F8M42_RS04400	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F8M42_RS04405	COG1966	Carbon starvation protein
F8M42_RS04410	COG0588	phosphoglycerate mutase activity
F8M42_RS04415	COG3875	lactate racemase activity
F8M42_RS04420	COG1902	pentaerythritol trinitrate reductase activity
F8M42_RS04430	COG1733	regulation of RNA biosynthetic process
F8M42_RS04440	COG0561	phosphatase activity
F8M42_RS04445	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
F8M42_RS04450	COG0242	peptide deformylase activity
F8M42_RS04455	COG0446	pyridine nucleotide-disulphide oxidoreductase
F8M42_RS04465	COG2194	sulfuric ester hydrolase activity
F8M42_RS04470	COG0525	valine-tRNA ligase activity
F8M42_RS04475	COG0285	dihydrofolate synthase activity
F8M42_RS04485	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
F8M42_RS04490	COG0427	acetyl-CoA hydrolase
F8M42_RS04495	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
F8M42_RS04495	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
F8M42_RS04500	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
F8M42_RS04500	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
F8M42_RS04510	COG0346	lactoylglutathione lyase activity
F8M42_RS04515	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
F8M42_RS04525	COG4770	biotin carboxylase activity
F8M42_RS04535	COG1126	abc transporter atp-binding protein
F8M42_RS04545	COG0582	viral genome integration into host DNA
F8M42_RS04570	COG5484	DNA packaging
F8M42_RS04570	COG3728	DNA packaging
F8M42_RS04620	COG3933	PFAM sigma-54 factor interaction domain-containing protein
F8M42_RS04620	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
F8M42_RS04630	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
F8M42_RS04635	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
F8M42_RS04640	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
F8M42_RS04645	COG0564	pseudouridine synthase activity
F8M42_RS04650	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
F8M42_RS04660	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
F8M42_RS04665	COG1799	cell septum assembly
F8M42_RS04670	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
F8M42_RS04685	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
F8M42_RS04690	COG1426	Protein conserved in bacteria
F8M42_RS04695	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
F8M42_RS04700	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
F8M42_RS04705	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
F8M42_RS04715	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
F8M42_RS04725	COG0688	phosphatidylethanolamine metabolic process
F8M42_RS04730	COG1183	phosphatidylcholine synthase activity
F8M42_RS04735	COG1215	transferase activity, transferring glycosyl groups
F8M42_RS04740	COG2390	Transcriptional regulator
F8M42_RS04750	COG0738	Major facilitator superfamily
F8M42_RS04760	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F8M42_RS04765	COG0720	synthase
F8M42_RS04770	COG0602	queuosine metabolic process
F8M42_RS04775	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
F8M42_RS04780	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
F8M42_RS04785	COG0402	S-adenosylhomocysteine deaminase activity
F8M42_RS04810	COG0012	GTP binding
F8M42_RS04820	COG0371	Dehydrogenase
F8M42_RS04825	COG0302	gtp cyclohydrolase
F8M42_RS04825	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
F8M42_RS04830	COG1418	mRNA catabolic process
F8M42_RS04840	COG3706	GGDEF domain
F8M42_RS04890	COG3328	transposase activity
F8M42_RS04895	COG3328	transposase activity
F8M42_RS04900	COG3829	transcription factor binding
F8M42_RS04925	COG0644	oxidoreductase
F8M42_RS04930	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
F8M42_RS04935	COG1960	acyl-CoA dehydrogenase activity
F8M42_RS04940	COG2086	electron transfer activity
F8M42_RS04945	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
F8M42_RS04950	COG2271	Major facilitator Superfamily
F8M42_RS04965	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
F8M42_RS04970	COG2183	response to ionizing radiation
F8M42_RS04980	COG1263	PTS System
F8M42_RS04980	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F8M42_RS04985	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
F8M42_RS04995	COG1114	Component of the transport system for branched-chain amino acids
F8M42_RS05000	COG1301	dicarboxylic acid transport
F8M42_RS05010	COG1091	dTDP-4-dehydrorhamnose reductase activity
F8M42_RS05015	COG0662	Cupin 2, conserved barrel domain protein
F8M42_RS05015	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
F8M42_RS05020	COG3384	dioxygenase
F8M42_RS05025	COG1434	Gram-negative-bacterium-type cell wall biogenesis
F8M42_RS05045	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
F8M42_RS05050	COG1210	Utp--glucose-1-phosphate uridylyltransferase
F8M42_RS05055	COG0166	Belongs to the GPI family
F8M42_RS05060	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
F8M42_RS05065	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
F8M42_RS05075	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
F8M42_RS05085	COG1108	ABC-type Mn2 Zn2 transport systems permease components
F8M42_RS05090	COG1121	(ABC) transporter
F8M42_RS05095	COG0803	Belongs to the bacterial solute-binding protein 9 family
F8M42_RS05100	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
F8M42_RS05105	COG0085	RNA polymerase activity
F8M42_RS05110	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
F8M42_RS05110	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
F8M42_RS05115	COG1360	Flagellar Motor Protein
F8M42_RS05120	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
F8M42_RS05130	COG2827	Endonuclease containing a URI domain
F8M42_RS05135	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
F8M42_RS05145	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
F8M42_RS05155	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
F8M42_RS05160	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
F8M42_RS05165	COG0513	Belongs to the DEAD box helicase family
F8M42_RS05170	COG1546	Belongs to the CinA family
F8M42_RS05170	COG1058	Belongs to the CinA family
F8M42_RS05175	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
F8M42_RS05180	COG1840	ABC-type Fe3 transport system, periplasmic component
F8M42_RS05185	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
F8M42_RS05205	COG1181	Belongs to the D-alanine--D-alanine ligase family
F8M42_RS05210	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
F8M42_RS05215	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
F8M42_RS05220	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
F8M42_RS05225	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
F8M42_RS05230	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
F8M42_RS05235	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
F8M42_RS05245	COG0275	rRNA processing
F8M42_RS05270	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
F8M42_RS05275	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
F8M42_RS05280	COG0058	SHG alpha-glucan phosphorylase activity
F8M42_RS05285	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
F8M42_RS05290	COG0297	glycogen (starch) synthase activity
F8M42_RS05295	COG3103	Sh3 type 3 domain protein
F8M42_RS05295	COG0366	Alpha amylase catalytic
F8M42_RS05300	COG1592	Rubrerythrin
F8M42_RS05305	COG0385	Bile acid
F8M42_RS05310	COG3706	GGDEF domain
F8M42_RS05315	COG0820	rRNA (adenine-C2-)-methyltransferase activity
F8M42_RS05320	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
F8M42_RS05320	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
F8M42_RS05330	COG1132	(ABC) transporter
F8M42_RS05340	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
F8M42_RS05360	COG0840	transmembrane signaling receptor activity
F8M42_RS05370	COG1126	abc transporter atp-binding protein
F8M42_RS05375	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F8M42_RS05380	COG0765	amino acid transport
F8M42_RS05385	COG0765	amino acid transport
F8M42_RS05390	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
F8M42_RS05395	COG0557	exoribonuclease II activity
F8M42_RS05420	COG2733	membrane
F8M42_RS05425	COG2733	membrane
F8M42_RS05455	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
F8M42_RS05465	COG1309	transcriptional regulator
F8M42_RS05470	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
F8M42_RS05470	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F8M42_RS05470	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F8M42_RS05475	COG1105	Belongs to the carbohydrate kinase PfkB family
F8M42_RS05485	COG3328	transposase activity
F8M42_RS05505	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
F8M42_RS05515	COG0588	phosphoglycerate mutase activity
F8M42_RS05520	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
F8M42_RS05530	COG0196	riboflavin kinase activity
F8M42_RS05540	COG1216	Glycosyl transferase, family 2
F8M42_RS05545	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
F8M42_RS05550	COG0210	DNA helicase
F8M42_RS05550	COG0210	DNA helicase
F8M42_RS05560	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
F8M42_RS05565	COG4122	O-methyltransferase activity
F8M42_RS05575	COG1254	Belongs to the acylphosphatase family
F8M42_RS05580	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
F8M42_RS05585	COG0006	proline dipeptidase activity
F8M42_RS05600	COG0211	Belongs to the bacterial ribosomal protein bL27 family
F8M42_RS05610	COG0261	This protein binds to 23S rRNA in the presence of protein L20
F8M42_RS05615	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
F8M42_RS05620	COG2814	Major facilitator Superfamily
F8M42_RS05625	COG1434	Gram-negative-bacterium-type cell wall biogenesis
F8M42_RS05630	COG0004	ammonium transporteR
F8M42_RS05635	COG0347	Belongs to the P(II) protein family
F8M42_RS05640	COG0840	transmembrane signaling receptor activity
F8M42_RS05645	COG0552	protein localization to endoplasmic reticulum
F8M42_RS05650	COG1196	nuclear chromosome segregation
F8M42_RS05660	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
F8M42_RS05665	COG0306	phosphate transporter
F8M42_RS05685	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
F8M42_RS05690	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
F8M42_RS05695	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
F8M42_RS05705	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
F8M42_RS05710	COG0138	bifunctional purine biosynthesis protein purh
F8M42_RS05715	COG0151	Belongs to the GarS family
F8M42_RS05720	COG2855	membrane
F8M42_RS05730	COG0583	DNA-binding transcription factor activity
F8M42_RS05735	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
F8M42_RS05740	COG0291	Belongs to the bacterial ribosomal protein bL35 family
F8M42_RS05750	COG0436	Aminotransferase
F8M42_RS05760	COG1116	anion transmembrane transporter activity
F8M42_RS05765	COG0252	asparaginase activity
F8M42_RS05775	COG0495	leucyl-tRNA aminoacylation
F8M42_RS05785	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
F8M42_RS05795	COG1323	Belongs to the UPF0348 family
F8M42_RS05805	COG0333	Belongs to the bacterial ribosomal protein bL32 family
F8M42_RS05810	COG0416	fatty acid biosynthetic process
F8M42_RS05815	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
F8M42_RS05825	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
F8M42_RS05830	COG1028	Short-chain dehydrogenase reductase Sdr
F8M42_RS05835	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F8M42_RS05845	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F8M42_RS05850	COG0571	ribonuclease III activity
F8M42_RS05860	COG1242	4 iron, 4 sulfur cluster binding
F8M42_RS05890	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
F8M42_RS05895	COG1253	flavin adenine dinucleotide binding
F8M42_RS05900	COG0205	6-phosphofructokinase activity
F8M42_RS05910	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
F8M42_RS05925	COG1408	metallophosphoesterase
F8M42_RS05955	COG2009	succinate dehydrogenase
F8M42_RS05960	COG1053	succinate dehydrogenase
F8M42_RS05965	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
F8M42_RS05975	COG1982	Orn Lys Arg decarboxylase major
F8M42_RS05980	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
F8M42_RS05985	COG0010	Belongs to the arginase family
F8M42_RS06010	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
F8M42_RS06020	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
F8M42_RS06025	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
F8M42_RS06030	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
F8M42_RS06035	COG1758	RNA polymerase activity
F8M42_RS06040	COG0194	GDP metabolic process
F8M42_RS06045	COG2052	Domain of unknown function (DUF370)
F8M42_RS06050	COG1561	YicC-like family, N-terminal region
F8M42_RS06055	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
F8M42_RS06060	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
F8M42_RS06070	COG0037	tRNA processing
F8M42_RS06080	COG0210	DNA helicase
F8M42_RS06085	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
F8M42_RS06090	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
F8M42_RS06095	COG0154	amidase activity
F8M42_RS06100	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
F8M42_RS06105	COG0758	DNA mediated transformation
F8M42_RS06110	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
F8M42_RS06115	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
F8M42_RS06120	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
F8M42_RS06125	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
F8M42_RS06135	COG1815	bacterial-type flagellum-dependent cell motility
F8M42_RS06140	COG1558	bacterial-type flagellum-dependent cell motility
F8M42_RS06145	COG1677	Flagellar hook-basal body complex protein FliE
F8M42_RS06150	COG1766	The M ring may be actively involved in energy transduction
F8M42_RS06155	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
F8M42_RS06165	COG1157	protein secretion by the type III secretion system
F8M42_RS06175	COG0741	lytic transglycosylase activity
F8M42_RS06190	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
F8M42_RS06200	COG1749	Flagellar hook protein flgE
F8M42_RS06215	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
F8M42_RS06220	COG1776	CheC inhibitor of MCP methylation
F8M42_RS06220	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
F8M42_RS06225	COG2201	protein-glutamate methylesterase activity
F8M42_RS06235	COG1338	Plays a role in the flagellum-specific transport system
F8M42_RS06240	COG1987	bacterial-type flagellum assembly
F8M42_RS06245	COG1684	flagellar biosynthetic protein fliR
F8M42_RS06250	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
F8M42_RS06255	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
F8M42_RS06260	COG1419	protein localization to endoplasmic reticulum
F8M42_RS06265	COG0455	bacterial-type flagellum organization
F8M42_RS06275	COG2201	protein-glutamate methylesterase activity
F8M42_RS06280	COG0643	Histidine kinase
F8M42_RS06280	COG2198	Histidine kinase
F8M42_RS06285	COG0835	chemotaxis
F8M42_RS06290	COG1776	CheC inhibitor of MCP methylation
F8M42_RS06295	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
F8M42_RS06300	COG1191	sigma factor activity
F8M42_RS06320	COG1187	pseudouridine synthase activity
F8M42_RS06325	COG2081	HI0933 family
F8M42_RS06335	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
F8M42_RS06340	COG0318	PFAM AMP-dependent synthetase and ligase
F8M42_RS06340	COG0204	Acyl-transferase
F8M42_RS06345	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
F8M42_RS06350	COG0539	negative regulation of cytoplasmic translation
F8M42_RS06360	COG1160	GTP binding
F8M42_RS06365	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
F8M42_RS06370	COG1923	regulation of RNA biosynthetic process
F8M42_RS06375	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
F8M42_RS06380	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
F8M42_RS06390	COG1362	aminopeptidase activity
F8M42_RS06400	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
F8M42_RS06410	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
F8M42_RS06415	COG0124	histidyl-tRNA synthetase
F8M42_RS06420	COG0635	Involved in the biosynthesis of porphyrin-containing compound
F8M42_RS06425	COG0735	belongs to the Fur family
F8M42_RS06440	COG0726	polysaccharide deacetylase
F8M42_RS06450	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
F8M42_RS06455	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
F8M42_RS06465	COG0726	polysaccharide deacetylase
F8M42_RS06470	COG3829	transcription factor binding
F8M42_RS06480	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
F8M42_RS06490	COG1803	Methylglyoxal synthase
F8M42_RS06495	COG0156	8-amino-7-oxononanoate synthase activity
F8M42_RS06500	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
F8M42_RS06510	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F8M42_RS06515	COG0039	L-malate dehydrogenase activity
F8M42_RS06525	COG3706	GGDEF domain
F8M42_RS06540	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
F8M42_RS06545	COG3437	response regulator, receiver
F8M42_RS06550	COG0756	dUTP diphosphatase activity
F8M42_RS06560	COG1959	2 iron, 2 sulfur cluster binding
F8M42_RS06580	COG4771	TonB-dependent receptor
F8M42_RS06600	COG0347	Belongs to the P(II) protein family
F8M42_RS06650	COG0393	Putative heavy-metal-binding
F8M42_RS06680	COG0671	phosphoesterase, PA-phosphatase related
F8M42_RS06700	COG0693	protein deglycase activity
F8M42_RS06720	COG2814	Major facilitator Superfamily
F8M42_RS06730	COG0789	Transcriptional regulator
F8M42_RS06745	COG0716	FMN binding
F8M42_RS06760	COG1213	nucleotidyl transferase
F8M42_RS06785	COG1691	(AIR) carboxylase
F8M42_RS06835	COG2003	Belongs to the UPF0758 family
F8M42_RS06850	COG4115	mRNA cleavage
F8M42_RS06890	COG0582	viral genome integration into host DNA
F8M42_RS06895	COG0582	viral genome integration into host DNA
F8M42_RS06900	COG3645	SOS response
F8M42_RS06940	COG3620	sequence-specific DNA binding
F8M42_RS06945	COG3328	transposase activity
F8M42_RS07030	COG5377	YqaJ viral recombinase family
F8M42_RS07035	COG3723	Recombinational DNA repair protein, rece pathway
F8M42_RS07040	COG3935	DnaD domain protein
F8M42_RS07060	COG5484	DNA packaging
F8M42_RS07155	COG3628	GPW Gp25 family protein
F8M42_RS07160	COG3299	homolog of phage Mu protein gp47
F8M42_RS07205	COG2848	UPF0210 protein
F8M42_RS07215	COG0542	response to heat
F8M42_RS07220	COG0674	pyruvate-flavodoxin oxidoreductase activity
F8M42_RS07220	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
F8M42_RS07225	COG1013	pyruvate-flavodoxin oxidoreductase activity
F8M42_RS07235	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
F8M42_RS07245	COG1799	cell septum assembly
F8M42_RS07255	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
F8M42_RS07260	COG3022	response to hydroperoxide
F8M42_RS07265	COG1139	Iron-sulfur cluster binding protein
F8M42_RS07275	COG0277	FAD linked oxidase domain protein
F8M42_RS07280	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
F8M42_RS07285	COG2086	electron transfer activity
F8M42_RS07290	COG1620	l-lactate permease
F8M42_RS07305	COG0860	N-Acetylmuramoyl-L-alanine amidase
F8M42_RS07310	COG2337	Toxic component of a toxin-antitoxin (TA) module
F8M42_RS07320	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F8M42_RS07340	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
F8M42_RS07345	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
F8M42_RS07350	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
F8M42_RS07355	COG2136	Putative SAM-dependent methyltransferase
F8M42_RS07355	COG2521	methyltransferase
F8M42_RS07365	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
F8M42_RS07370	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
F8M42_RS07390	COG2267	carboxylic ester hydrolase activity
F8M42_RS07420	COG3328	transposase activity
F8M42_RS07440	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F8M42_RS07440	COG1263	PTS System
F8M42_RS07445	COG1486	melibiose metabolic process
F8M42_RS07450	COG1737	Transcriptional regulator
F8M42_RS07470	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
F8M42_RS07505	COG0191	fructose-bisphosphate aldolase activity
F8M42_RS07525	COG0640	Transcriptional regulator
F8M42_RS07550	COG2508	Transcriptional regulator
F8M42_RS07555	COG0402	S-adenosylhomocysteine deaminase activity
F8M42_RS07565	COG1024	Enoyl-CoA hydratase
F8M42_RS07585	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
F8M42_RS07605	COG1063	alcohol dehydrogenase
F8M42_RS07615	COG3732	PTS system glucitol sorbitol-specific
F8M42_RS07620	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
F8M42_RS07630	COG0215	cysteine-tRNA ligase activity
F8M42_RS07635	COG1045	serine acetyltransferase
F8M42_RS07640	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
F8M42_RS07645	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
F8M42_RS07650	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
F8M42_RS07655	COG4956	integral membrane protein (PIN domain superfamily)
F8M42_RS07660	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
F8M42_RS07665	COG0542	response to heat
F8M42_RS07670	COG3869	Catalyzes the specific phosphorylation of arginine residues in
F8M42_RS07675	COG3880	PFAM UvrB UvrC protein
F8M42_RS07680	COG4463	regulation of RNA biosynthetic process
F8M42_RS07685	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
F8M42_RS07690	COG1388	LysM domain
F8M42_RS07690	COG3103	Sh3 type 3 domain protein
F8M42_RS07690	COG0791	NLP P60 protein
F8M42_RS07720	COG0037	tRNA processing
F8M42_RS07725	COG1098	S1 RNA binding domain
F8M42_RS07735	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
F8M42_RS07740	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
F8M42_RS07740	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
F8M42_RS07745	COG1918	ferrous iron import across plasma membrane
F8M42_RS07765	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
F8M42_RS07770	COG0105	UTP biosynthetic process
F8M42_RS07780	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
F8M42_RS07790	COG1272	protein, Hemolysin III
F8M42_RS07795	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
F8M42_RS07800	COG0579	oxidoreductase
F8M42_RS07845	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
F8M42_RS07850	COG0515	serine threonine protein kinase
F8M42_RS07850	COG2815	serine threonine protein kinase
F8M42_RS07865	COG0631	protein serine/threonine phosphatase activity
F8M42_RS07880	COG1937	Protein conserved in bacteria
F8M42_RS07890	COG2721	sulfolactate sulfo-lyase activity
F8M42_RS07895	COG0246	Mannitol dehydrogenase
F8M42_RS07905	COG2211	Major facilitator Superfamily
F8M42_RS07910	COG1904	glucuronate isomerase
F8M42_RS07915	COG1609	Transcriptional regulator
F8M42_RS07920	COG0165	Argininosuccinate lyase
F8M42_RS07925	COG0137	argininosuccinate synthase activity
F8M42_RS07930	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
F8M42_RS07935	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
F8M42_RS07940	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
F8M42_RS07945	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
F8M42_RS07950	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
F8M42_RS07975	COG0469	pyruvate kinase activity
F8M42_RS08000	COG0126	phosphoglycerate kinase activity
F8M42_RS08025	COG0726	polysaccharide deacetylase
F8M42_RS08030	COG1481	regulation of sporulation
F8M42_RS08035	COG0391	Required for morphogenesis under gluconeogenic growth conditions
F8M42_RS08040	COG1660	Displays ATPase and GTPase activities
F8M42_RS08045	COG0561	phosphatase activity
F8M42_RS08050	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
F8M42_RS08055	COG0459	protein refolding
F8M42_RS08065	COG2814	Major facilitator Superfamily
F8M42_RS08070	COG1882	Formate acetyltransferase
F8M42_RS08075	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
F8M42_RS08090	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F8M42_RS08100	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
F8M42_RS08100	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
F8M42_RS08105	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
F8M42_RS08105	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
F8M42_RS08120	COG3511	phospholipase C
F8M42_RS08130	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
F8M42_RS08135	COG1882	Formate acetyltransferase
F8M42_RS08140	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F8M42_RS08145	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F8M42_RS08150	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F8M42_RS08150	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F8M42_RS08150	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
F8M42_RS08155	COG3711	transcriptional antiterminator
F8M42_RS08155	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
F8M42_RS08160	COG0222	ribosome binding
F8M42_RS08165	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
F8M42_RS08170	COG0081	regulation of translation
F8M42_RS08175	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
F8M42_RS08180	COG0250	Participates in transcription elongation, termination and antitermination
F8M42_RS08190	COG0267	Belongs to the bacterial ribosomal protein bL33 family
F8M42_RS08220	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
F8M42_RS08225	COG0719	Fe-S assembly protein
F8M42_RS08230	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
F8M42_RS08245	COG0537	adenosine 5'-monophosphoramidase activity
F8M42_RS08250	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
F8M42_RS08255	COG1385	rRNA (uridine-N3-)-methyltransferase activity
F8M42_RS08260	COG2264	protein methyltransferase activity
F8M42_RS08265	COG0287	Prephenate dehydrogenase
F8M42_RS08270	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
F8M42_RS08290	COG1030	water channel activity
F8M42_RS08295	COG4864	UPF0365 protein
F8M42_RS08315	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
F8M42_RS08335	COG0613	PHP domain protein
F8M42_RS08340	COG0322	excinuclease ABC activity
F8M42_RS08350	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
F8M42_RS08355	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
F8M42_RS08365	COG0765	amino acid transport
F8M42_RS08375	COG0024	Methionine aminopeptidase
F8M42_RS08380	COG2884	Cell division ATP-binding protein ftsE
F8M42_RS08385	COG2177	Part of the ABC transporter FtsEX involved in
F8M42_RS08390	COG4942	peptidase
F8M42_RS08395	COG0793	Belongs to the peptidase S41A family
F8M42_RS08405	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
F8M42_RS08415	COG1116	anion transmembrane transporter activity
F8M42_RS08425	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
F8M42_RS08430	COG1228	amidohydrolase
F8M42_RS08435	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F8M42_RS08450	COG0402	S-adenosylhomocysteine deaminase activity
F8M42_RS08470	COG5433	transposase activity
F8M42_RS08480	COG2814	Major facilitator Superfamily
F8M42_RS08485	COG3962	Belongs to the TPP enzyme family
F8M42_RS08500	COG0191	fructose-bisphosphate aldolase activity
F8M42_RS08510	COG1349	DNA-binding transcription factor activity
F8M42_RS08515	COG1447	Phosphotransferase system cellobiose-specific component IIA
F8M42_RS08520	COG0673	inositol 2-dehydrogenase activity
F8M42_RS08530	COG0531	amino acid
F8M42_RS08535	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
F8M42_RS08540	COG0556	nucleotide-excision repair
F8M42_RS08545	COG0583	DNA-binding transcription factor activity
F8M42_RS08555	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
F8M42_RS08570	COG3732	PTS system glucitol sorbitol-specific
F8M42_RS08605	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
F8M42_RS08610	COG2203	Gaf domain
F8M42_RS08610	COG3706	GGDEF domain
F8M42_RS08610	COG4251	negative regulation of phosphorylation
F8M42_RS08610	COG5001	Diguanylate cyclase
F8M42_RS08630	COG3716	PTS system mannose fructose sorbose family IID component
F8M42_RS08635	COG1879	ABC-type sugar transport system periplasmic component
F8M42_RS08640	COG2197	response regulator
F8M42_RS08650	COG0561	phosphatase activity
F8M42_RS08655	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
F8M42_RS08660	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
F8M42_RS08665	COG3706	GGDEF domain
F8M42_RS08715	COG1773	rubredoxin
F8M42_RS08725	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
F8M42_RS08730	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
F8M42_RS08740	COG0840	transmembrane signaling receptor activity
F8M42_RS08755	COG0697	spore germination
F8M42_RS08760	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
F8M42_RS08765	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
F8M42_RS08770	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
F8M42_RS08780	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
F8M42_RS08785	COG4943	cyclic-guanylate-specific phosphodiesterase activity
F8M42_RS08795	COG0442	prolyl-tRNA aminoacylation
F8M42_RS08800	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
F8M42_RS08805	COG0750	zinc metalloprotease
F8M42_RS08810	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
F8M42_RS08820	COG0575	Belongs to the CDS family
F8M42_RS08825	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
F8M42_RS08840	COG0233	cytoplasmic translational termination
F8M42_RS08845	COG0528	UMP kinase activity
F8M42_RS08855	COG0052	Belongs to the universal ribosomal protein uS2 family
F8M42_RS08860	COG0497	DNA recombination
F8M42_RS08865	COG0497	DNA recombination
F8M42_RS08870	COG2731	YhcH YjgK YiaL family protein
F8M42_RS08880	COG1447	Phosphotransferase system cellobiose-specific component IIA
F8M42_RS08895	COG2723	6-phospho-beta-galactosidase activity
F8M42_RS08925	COG1473	amidohydrolase
F8M42_RS08930	COG3069	C4-dicarboxylate transmembrane transporter activity
F8M42_RS08935	COG1027	Aspartate ammonia-lyase
F8M42_RS08940	COG0784	Response regulator, receiver
F8M42_RS08945	COG4191	Histidine kinase
F8M42_RS08950	COG0471	metal ion transport
F8M42_RS08955	COG1027	Aspartate ammonia-lyase
F8M42_RS08980	COG5564	TIM-barrel signal transduction protein
F8M42_RS08995	COG5564	TIM-barrel signal transduction protein
F8M42_RS09000	COG4251	negative regulation of phosphorylation
F8M42_RS09010	COG2207	Transcriptional regulator
F8M42_RS09010	COG4753	response regulator
F8M42_RS09040	COG0831	urea catabolic process
F8M42_RS09045	COG0831	urea catabolic process
F8M42_RS09045	COG0832	Belongs to the urease beta subunit family
F8M42_RS09055	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
F8M42_RS09060	COG0830	nickel cation binding
F8M42_RS09065	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
F8M42_RS09070	COG0829	nickel cation binding
F8M42_RS09075	COG2843	Capsule synthesis protein
F8M42_RS09080	COG0167	dihydroorotate dehydrogenase activity
F8M42_RS09085	COG0543	2 iron, 2 sulfur cluster binding
F8M42_RS09095	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
F8M42_RS09100	COG2814	Major facilitator Superfamily
F8M42_RS09105	COG1414	Transcriptional regulator
F8M42_RS09110	COG0252	asparaginase activity
F8M42_RS09135	COG2801	Transposase and inactivated derivatives
F8M42_RS09140	COG1136	(ABC) transporter
F8M42_RS09145	COG1136	(ABC) transporter
F8M42_RS09145	COG0577	efflux transmembrane transporter activity
F8M42_RS09155	COG1737	Transcriptional regulator
F8M42_RS09165	COG1830	Aldolase
F8M42_RS09170	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F8M42_RS09175	COG2271	Major facilitator Superfamily
F8M42_RS09185	COG4585	Histidine kinase
F8M42_RS09190	COG2197	response regulator
F8M42_RS09195	COG0778	Nitroreductase
F8M42_RS09195	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
F8M42_RS09200	COG3775	system Galactitol-specific IIC component
F8M42_RS09205	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F8M42_RS09210	COG1028	Short-chain dehydrogenase reductase Sdr
F8M42_RS09245	COG2357	RelA SpoT domain protein
F8M42_RS09255	COG2195	Cleaves the N-terminal amino acid of tripeptides
F8M42_RS09260	COG3069	C4-dicarboxylate transmembrane transporter activity
F8M42_RS09275	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F8M42_RS09285	COG0438	transferase activity, transferring glycosyl groups
F8M42_RS09300	COG1216	Glycosyl transferase, family 2
F8M42_RS09320	COG0110	maltose O-acetyltransferase activity
F8M42_RS09345	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
F8M42_RS09355	COG2089	acid synthase
F8M42_RS09365	COG3980	spore coat polysaccharide biosynthesis protein
F8M42_RS09370	COG1083	cytidylyl-transferase
F8M42_RS09375	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
F8M42_RS09380	COG1086	Polysaccharide biosynthesis protein
F8M42_RS09385	COG1132	(ABC) transporter
F8M42_RS09390	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
F8M42_RS09395	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F8M42_RS09410	COG1442	glycosyl transferase family 8
F8M42_RS09425	COG2188	Transcriptional regulator
F8M42_RS09430	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
F8M42_RS09435	COG2188	Transcriptional regulator
F8M42_RS09440	COG3659	wide pore channel activity
F8M42_RS09460	COG2723	6-phospho-beta-galactosidase activity
F8M42_RS09470	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
F8M42_RS09475	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
F8M42_RS09480	COG3716	PTS system mannose fructose sorbose family IID component
F8M42_RS09490	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
F8M42_RS09490	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F8M42_RS09505	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
F8M42_RS09505	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
F8M42_RS09510	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
F8M42_RS09510	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
F8M42_RS09515	COG0859	PFAM glycosyl transferase family 9
F8M42_RS09530	COG0438	transferase activity, transferring glycosyl groups
F8M42_RS09535	COG2852	Protein conserved in bacteria
F8M42_RS09555	COG2852	Protein conserved in bacteria
F8M42_RS09565	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
F8M42_RS09570	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
F8M42_RS09575	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
F8M42_RS09580	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
F8M42_RS09580	COG3064	Membrane
F8M42_RS09590	COG2740	Nucleic-acid-binding protein implicated in transcription termination
F8M42_RS09595	COG0195	Participates in both transcription termination and antitermination
F8M42_RS09600	COG0779	Required for maturation of 30S ribosomal subunits
F8M42_RS09610	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F8M42_RS09625	COG2137	regulation of response to DNA damage stimulus
F8M42_RS09630	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
F8M42_RS09645	COG3956	TIGRFAM MazG family protein
F8M42_RS09650	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
F8M42_RS09660	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
F8M42_RS09665	COG0227	Belongs to the bacterial ribosomal protein bL28 family
F8M42_RS09675	COG2195	Cleaves the N-terminal amino acid of tripeptides
F8M42_RS09680	COG0358	DNA primase activity
F8M42_RS09685	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
F8M42_RS09690	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
F8M42_RS09695	COG0772	Belongs to the SEDS family
F8M42_RS09700	COG0220	tRNA (guanine-N7-)-methyltransferase activity
F8M42_RS09705	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
F8M42_RS09715	COG2723	6-phospho-beta-galactosidase activity
F8M42_RS09730	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
F8M42_RS09745	COG1013	pyruvate-flavodoxin oxidoreductase activity
F8M42_RS09750	COG0674	pyruvate-flavodoxin oxidoreductase activity
F8M42_RS09750	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
F8M42_RS09780	COG1193	negative regulation of DNA recombination
F8M42_RS09785	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
F8M42_RS09795	COG0217	transcriptional regulatory protein
F8M42_RS09800	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
F8M42_RS09805	COG0632	four-way junction helicase activity
F8M42_RS09810	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F8M42_RS09830	COG0799	negative regulation of ribosome biogenesis
F8M42_RS09835	COG2996	Protein conserved in bacteria
F8M42_RS09840	COG0835	chemotaxis
F8M42_RS09840	COG0784	Response regulator, receiver
F8M42_RS09845	COG4492	Belongs to the UPF0735 family
F8M42_RS09850	COG0460	homoserine dehydrogenase
F8M42_RS09855	COG0083	homoserine kinase activity
F8M42_RS09860	COG0617	tRNA 3'-terminal CCA addition
F8M42_RS09865	COG0840	transmembrane signaling receptor activity
F8M42_RS09870	COG1739	Uncharacterized protein family UPF0029
F8M42_RS09875	COG0833	amino acid
F8M42_RS09880	COG0148	phosphopyruvate hydratase activity
F8M42_RS09885	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F8M42_RS09885	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F8M42_RS09900	COG0861	Integral membrane protein TerC family
F8M42_RS09910	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F8M42_RS09915	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F8M42_RS09930	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
F8M42_RS09945	COG0842	Transport permease protein
F8M42_RS09960	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
F8M42_RS09965	COG1760	l-serine dehydratase
F8M42_RS09970	COG1760	l-serine dehydratase
F8M42_RS09975	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
F8M42_RS09980	COG2207	Transcriptional regulator
F8M42_RS09980	COG3708	Transcriptional regulator
F8M42_RS10000	COG0561	phosphatase activity
F8M42_RS10005	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
F8M42_RS10005	COG3933	PFAM sigma-54 factor interaction domain-containing protein
F8M42_RS10010	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F8M42_RS10015	COG0191	fructose-bisphosphate aldolase activity
F8M42_RS10020	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F8M42_RS10040	COG1309	transcriptional regulator
F8M42_RS10045	COG2814	Major facilitator Superfamily
F8M42_RS10055	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
F8M42_RS10060	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
F8M42_RS10065	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
F8M42_RS10070	COG2706	6-phosphogluconolactonase activity
F8M42_RS10085	COG0745	RESPONSE REGULATOR receiver
F8M42_RS10090	COG2205	protein histidine kinase activity
F8M42_RS10095	COG0745	RESPONSE REGULATOR receiver
F8M42_RS10100	COG2205	protein histidine kinase activity
F8M42_RS10110	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
F8M42_RS10115	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
F8M42_RS10125	COG1007	ATP synthesis coupled electron transport
F8M42_RS10130	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F8M42_RS10135	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
F8M42_RS10140	COG0713	ATP synthesis coupled electron transport
F8M42_RS10155	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
F8M42_RS10160	COG0649	NAD binding
F8M42_RS10165	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F8M42_RS10170	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F8M42_RS10175	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F8M42_RS10185	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F8M42_RS10190	COG0785	Cytochrome C biogenesis protein
F8M42_RS10210	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
F8M42_RS10230	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
F8M42_RS10235	COG0336	Belongs to the RNA methyltransferase TrmD family
F8M42_RS10240	COG0335	large ribosomal subunit rRNA binding
F8M42_RS10245	COG0681	Belongs to the peptidase S26 family
F8M42_RS10250	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
F8M42_RS10260	COG1794	racemase activity, acting on amino acids and derivatives
F8M42_RS10275	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
F8M42_RS10280	COG0792	nuclease activity
F8M42_RS10285	COG0163	prenyltransferase activity
F8M42_RS10290	COG0606	chelatase, subunit chli
F8M42_RS10295	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
F8M42_RS10300	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
F8M42_RS10305	COG2805	Type II/IV secretion system protein
F8M42_RS10310	COG1459	type II secretion system
F8M42_RS10380	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
F8M42_RS10385	COG1737	Transcriptional regulator
F8M42_RS10395	COG1420	regulation of RNA biosynthetic process
F8M42_RS10400	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
F8M42_RS10405	COG0443	Heat shock 70 kDa protein
F8M42_RS10430	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
F8M42_RS10455	COG3775	system Galactitol-specific IIC component
F8M42_RS10480	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
F8M42_RS10500	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
F8M42_RS10505	COG0742	ribosomal rna small subunit methyltransferase
F8M42_RS10510	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
F8M42_RS10510	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
F8M42_RS10520	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
F8M42_RS10525	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
F8M42_RS10530	COG0805	protein transport
F8M42_RS10535	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
F8M42_RS10540	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
F8M42_RS10545	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
F8M42_RS10550	COG2759	Belongs to the formate--tetrahydrofolate ligase family
F8M42_RS10560	COG2359	stage V sporulation protein S
F8M42_RS10565	COG1692	metallophosphoesterase
F8M42_RS10575	COG1418	mRNA catabolic process
F8M42_RS10580	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
F8M42_RS10595	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
F8M42_RS10600	COG0546	phosphoglycolate phosphatase activity
F8M42_RS10615	COG1192	Involved in chromosome partitioning
F8M42_RS10640	COG0583	DNA-binding transcription factor activity
F8M42_RS10645	COG0583	DNA-binding transcription factor activity
F8M42_RS10685	COG1028	Short-chain dehydrogenase reductase Sdr
F8M42_RS10705	COG1595	DNA-templated transcription, initiation
F8M42_RS10745	COG4962	Type ii secretion system protein e
F8M42_RS10760	COG3451	type IV secretory pathway VirB4
F8M42_RS10790	COG1396	sequence-specific DNA binding
F8M42_RS10795	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
F8M42_RS10815	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F8M42_RS10820	COG1131	(ABC) transporter
F8M42_RS10825	COG1131	(ABC) transporter
F8M42_RS10830	COG0842	Transport permease protein
F8M42_RS10835	COG0842	Transport permease protein
F8M42_RS10845	COG2226	methyltransferase
F8M42_RS10850	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F8M42_RS10955	COG5433	transposase activity
F8M42_RS10980	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
F8M42_RS10985	COG1518	maintenance of DNA repeat elements
F8M42_RS10990	COG1468	defense response to virus
F8M42_RS10990	COG1518	maintenance of DNA repeat elements
F8M42_RS11025	COG1151	hydroxylamine reductase activity
F8M42_RS11045	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
F8M42_RS11045	COG0493	'glutamate synthase
F8M42_RS11075	COG2099	Precorrin-6x reductase
F8M42_RS11090	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
F8M42_RS11090	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F8M42_RS11095	COG0463	Glycosyl transferase, family 2
F8M42_RS11100	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
F8M42_RS11105	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
F8M42_RS11110	COG0745	RESPONSE REGULATOR receiver
F8M42_RS11115	COG5002	protein histidine kinase activity
F8M42_RS11120	COG1297	OPT oligopeptide transporter protein
F8M42_RS11145	COG0768	penicillin binding
F8M42_RS11150	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
F8M42_RS11155	COG1285	pathogenesis
F8M42_RS11165	COG4145	pantothenate transmembrane transporter activity
F8M42_RS11175	COG1012	belongs to the aldehyde dehydrogenase family
F8M42_RS11190	COG1349	DNA-binding transcription factor activity
F8M42_RS11200	COG1733	regulation of RNA biosynthetic process
F8M42_RS11210	COG0471	metal ion transport
F8M42_RS11215	COG3052	prosthetic group binding
F8M42_RS11230	COG0583	DNA-binding transcription factor activity
F8M42_RS11240	COG0812	UDP-N-acetylmuramate dehydrogenase activity
F8M42_RS11245	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
F8M42_RS11250	COG1185	polyribonucleotide nucleotidyltransferase activity
F8M42_RS11255	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
F8M42_RS11275	COG2720	vancomycin resistance protein
F8M42_RS11285	COG0187	DNA topoisomerase II activity
F8M42_RS11300	COG1492	cobalamin metabolic process
F8M42_RS11320	COG0840	transmembrane signaling receptor activity
F8M42_RS11320	COG3290	protein histidine kinase activity
F8M42_RS11325	COG1966	Carbon starvation protein
F8M42_RS11330	COG0726	polysaccharide deacetylase
F8M42_RS11350	COG1285	pathogenesis
F8M42_RS11365	COG0351	phosphomethylpyrimidine kinase
F8M42_RS11365	COG0352	thiamine-phosphate diphosphorylase activity
F8M42_RS11370	COG0561	phosphatase activity
F8M42_RS11395	COG0840	transmembrane signaling receptor activity
F8M42_RS11415	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
F8M42_RS11435	COG1342	Belongs to the UPF0251 family
F8M42_RS11440	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
F8M42_RS11445	COG0129	dihydroxy-acid dehydratase activity
F8M42_RS11450	COG0385	Bile acid
F8M42_RS11455	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
F8M42_RS11460	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
F8M42_RS11470	COG0157	Belongs to the NadC ModD family
F8M42_RS11475	COG1827	regulation of RNA biosynthetic process
F8M42_RS11485	COG0765	amino acid transport
F8M42_RS11490	COG1126	abc transporter atp-binding protein
F8M42_RS11500	COG0626	cystathionine gamma-synthase activity
F8M42_RS11505	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
F8M42_RS11510	COG0583	DNA-binding transcription factor activity
F8M42_RS11515	COG2814	Major facilitator Superfamily
F8M42_RS11520	COG3933	PFAM sigma-54 factor interaction domain-containing protein
F8M42_RS11520	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
F8M42_RS11525	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
F8M42_RS11530	COG3414	Phosphotransferase system galactitol-specific IIB component
F8M42_RS11535	COG3775	system Galactitol-specific IIC component
F8M42_RS11540	COG0235	Class ii aldolase
F8M42_RS11545	COG2376	Dihydroxyacetone kinase
F8M42_RS11555	COG1733	regulation of RNA biosynthetic process
F8M42_RS11560	COG2249	NAD(P)H dehydrogenase (quinone) activity
F8M42_RS11575	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
F8M42_RS11580	COG0066	3-isopropylmalate dehydratase activity
F8M42_RS11585	COG0473	3-isopropylmalate dehydrogenase activity
F8M42_RS11590	COG0848	biopolymer transport protein
F8M42_RS11595	COG0811	peptide transport
F8M42_RS11610	COG1120	ATPase activity
F8M42_RS11635	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F8M42_RS11640	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
F8M42_RS11660	COG4771	TonB-dependent receptor
F8M42_RS11675	COG0735	belongs to the Fur family
F8M42_RS11680	COG0730	response to heat
F8M42_RS11685	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
F8M42_RS11695	COG3588	fructose-bisphosphate aldolase
F8M42_RS11715	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
F8M42_RS11725	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
F8M42_RS11735	COG0254	rRNA binding
F8M42_RS11740	COG3872	metal-dependent enzyme
F8M42_RS11745	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
F8M42_RS11750	COG2890	protein-(glutamine-N5) methyltransferase activity
F8M42_RS11755	COG0009	L-threonylcarbamoyladenylate synthase
F8M42_RS11760	COG0698	ribose 5-phosphate isomerase
F8M42_RS11765	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
F8M42_RS11780	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
F8M42_RS11785	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
F8M42_RS11790	COG0840	transmembrane signaling receptor activity
F8M42_RS11795	COG0725	ABC transporter, periplasmic molybdate-binding protein
F8M42_RS11800	COG4149	molybdate abc transporter
F8M42_RS11805	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
F8M42_RS11810	COG3585	molybdate ion transport
F8M42_RS11820	COG1268	BioY protein
F8M42_RS11845	COG0268	Binds directly to 16S ribosomal RNA
F8M42_RS11855	COG4771	TonB-dependent receptor
F8M42_RS11905	COG3118	belongs to the thioredoxin family
F8M42_RS11920	COG2084	Dehydrogenase
F8M42_RS11925	COG0686	Belongs to the AlaDH PNT family
F8M42_RS11940	COG0114	fumarate hydratase activity
F8M42_RS11965	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
F8M42_RS11970	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F8M42_RS11980	COG1278	Cold shock
F8M42_RS11985	COG0534	Mate efflux family protein
F8M42_RS12000	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
F8M42_RS12005	COG2194	sulfuric ester hydrolase activity
F8M42_RS12015	COG3711	transcriptional antiterminator
F8M42_RS12015	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
F8M42_RS12035	COG3959	Transketolase, thiamine diphosphate binding domain
F8M42_RS12040	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
F8M42_RS12055	COG0477	Major facilitator Superfamily
F8M42_RS12060	COG1309	transcriptional regulator
F8M42_RS12070	COG1695	Transcriptional regulator
F8M42_RS12085	COG3293	Transposase
F8M42_RS12090	COG3328	transposase activity
F8M42_RS12100	COG0789	Transcriptional regulator
F8M42_RS12100	COG4978	Transcriptional regulator
F8M42_RS12110	COG3012	SEC-C Motif Domain Protein
F8M42_RS12120	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
F8M42_RS12120	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F8M42_RS12120	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F8M42_RS12125	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F8M42_RS12135	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F8M42_RS12135	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
F8M42_RS12135	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F8M42_RS12145	COG2207	Transcriptional regulator
F8M42_RS12145	COG3708	Transcriptional regulator
F8M42_RS12150	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F8M42_RS12175	COG0517	IMP dehydrogenase activity
F8M42_RS12195	COG0559	Belongs to the binding-protein-dependent transport system permease family
F8M42_RS12205	COG1482	cell wall glycoprotein biosynthetic process
F8M42_RS12210	COG2223	nitrite transmembrane transporter activity
F8M42_RS12225	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
F8M42_RS12230	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
F8M42_RS12235	COG0860	N-Acetylmuramoyl-L-alanine amidase
F8M42_RS12240	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
F8M42_RS12250	COG4208	sulfate ABC transporter
F8M42_RS12255	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
F8M42_RS12270	COG0175	sulfate reduction
F8M42_RS12285	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
F8M42_RS12290	COG0517	IMP dehydrogenase activity
F8M42_RS12295	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
F8M42_RS12295	COG0574	Belongs to the PEP-utilizing enzyme family
F8M42_RS12305	COG3620	sequence-specific DNA binding
F8M42_RS12310	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
F8M42_RS12355	COG2217	Heavy metal translocating P-type atpase
F8M42_RS12370	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F8M42_RS12380	COG0039	L-malate dehydrogenase activity
F8M42_RS12420	COG0732	type I restriction modification DNA specificity domain
F8M42_RS12445	COG5433	transposase activity
F8M42_RS12450	COG5433	transposase activity
F8M42_RS12465	COG3328	transposase activity
F8M42_RS12530	COG0305	Participates in initiation and elongation during chromosome replication
F8M42_RS12535	COG0470	DNA polymerase III
F8M42_RS12535	COG1067	ATP-dependent peptidase activity
F8M42_RS12540	COG0359	binds to the 23S rRNA
F8M42_RS12545	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
F8M42_RS12560	COG0248	Ppx GppA phosphatase
F8M42_RS12580	COG1316	TRANSCRIPTIONal
F8M42_RS12605	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
F8M42_RS12610	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
F8M42_RS12625	COG0288	reversible hydration of carbon dioxide
F8M42_RS12630	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
F8M42_RS12640	COG0310	cobalt ion transport
F8M42_RS12650	COG1122	ATPase activity
F8M42_RS12655	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
F8M42_RS12665	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F8M42_RS12665	COG0072	phenylalanine-tRNA ligase activity
F8M42_RS12670	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
F8M42_RS12675	COG1113	amino acid transport
F8M42_RS12680	COG0751	glycine-tRNA ligase activity
F8M42_RS12685	COG0752	glycyl-tRNA synthetase alpha subunit
F8M42_RS12700	COG0446	pyridine nucleotide-disulphide oxidoreductase
F8M42_RS12710	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
F8M42_RS12740	COG2217	Heavy metal translocating P-type atpase
F8M42_RS12745	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
F8M42_RS12750	COG1802	Transcriptional regulator
F8M42_RS12755	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
F8M42_RS12760	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
F8M42_RS12770	COG0193	aminoacyl-tRNA hydrolase activity
F8M42_RS12780	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
F8M42_RS12790	COG0419	ATPase involved in DNA repair
F8M42_RS12795	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
F8M42_RS12830	COG0765	amino acid transport
F8M42_RS12840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F8M42_RS12850	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
F8M42_RS12855	COG2011	ABC-type metal ion transport system permease component
F8M42_RS12860	COG1464	Belongs to the NlpA lipoprotein family
F8M42_RS12870	COG1982	Orn Lys Arg decarboxylase major
F8M42_RS12875	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
F8M42_RS12885	COG0840	transmembrane signaling receptor activity
F8M42_RS12890	COG0584	glycerophosphoryl diester phosphodiesterase
F8M42_RS12895	COG3842	ATPase activity
F8M42_RS12900	COG1653	transport
F8M42_RS12905	COG0395	ABC-type sugar transport system, permease component
F8M42_RS12910	COG1175	transmembrane transport
F8M42_RS12925	COG0735	belongs to the Fur family
F8M42_RS12940	COG0840	transmembrane signaling receptor activity
F8M42_RS12945	COG0861	Integral membrane protein TerC family
F8M42_RS12955	COG5433	transposase activity
F8M42_RS12960	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
F8M42_RS12975	COG1929	Belongs to the glycerate kinase type-1 family
F8M42_RS12980	COG0318	PFAM AMP-dependent synthetase and ligase
F8M42_RS12995	COG3730	PTS system glucitol sorbitol-specific
F8M42_RS13000	COG3732	PTS system glucitol sorbitol-specific
F8M42_RS13020	COG0471	metal ion transport
F8M42_RS13025	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
F8M42_RS13030	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
F8M42_RS13035	COG0436	Aminotransferase
F8M42_RS13040	COG1522	sequence-specific DNA binding
F8M42_RS13045	COG2814	Major facilitator Superfamily
F8M42_RS13055	COG1309	transcriptional regulator
F8M42_RS13070	COG1846	Transcriptional regulator
F8M42_RS13075	COG1309	transcriptional regulator
F8M42_RS13095	COG0840	transmembrane signaling receptor activity
F8M42_RS13100	COG0386	Belongs to the glutathione peroxidase family
F8M42_RS13110	COG0840	transmembrane signaling receptor activity
F8M42_RS13125	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
F8M42_RS13135	COG1979	alcohol dehydrogenase
F8M42_RS13140	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F8M42_RS13160	COG1028	Short-chain dehydrogenase reductase Sdr
F8M42_RS13170	COG0519	Catalyzes the synthesis of GMP from XMP
F8M42_RS13175	COG1395	domain, Protein
F8M42_RS13195	COG1073	alpha beta
F8M42_RS13195	COG3064	Membrane
F8M42_RS13195	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
F8M42_RS13225	COG3328	transposase activity
F8M42_RS13235	COG0840	transmembrane signaling receptor activity
F8M42_RS13270	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
F8M42_RS13270	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
F8M42_RS13280	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F8M42_RS13280	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F8M42_RS13290	COG0622	Phosphoesterase
F8M42_RS13295	COG0772	Belongs to the SEDS family
F8M42_RS13315	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
F8M42_RS13330	COG3366	ferrous iron transmembrane transporter activity
F8M42_RS13335	COG0700	Nucleoside recognition
F8M42_RS13340	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
F8M42_RS13345	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
F8M42_RS13350	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
F8M42_RS13355	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
F8M42_RS13360	COG0232	Belongs to the dGTPase family. Type 2 subfamily
F8M42_RS13370	COG0440	acetolactate synthase activity
F8M42_RS13375	COG0028	Belongs to the TPP enzyme family
F8M42_RS13380	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
F8M42_RS13385	COG0028	Belongs to the TPP enzyme family
F8M42_RS13390	COG0440	acetolactate synthase activity
F8M42_RS13395	COG0697	spore germination
F8M42_RS13400	COG1126	abc transporter atp-binding protein
F8M42_RS13405	COG0765	amino acid transport
F8M42_RS13410	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F8M42_RS13420	COG2022	thiamine diphosphate biosynthetic process
F8M42_RS13430	COG0352	thiamine-phosphate diphosphorylase activity
F8M42_RS13435	COG0390	transport system, permease component
F8M42_RS13440	COG4619	ABC transporter
F8M42_RS13450	COG2033	superoxide reductase activity
F8M42_RS13465	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
F8M42_RS13475	COG1475	DNA binding
F8M42_RS13480	COG1192	Involved in chromosome partitioning
F8M42_RS13490	COG1410	methionine synthase
F8M42_RS13490	COG0646	methionine synthase
F8M42_RS13495	COG0205	6-phosphofructokinase activity
F8M42_RS13500	COG0138	bifunctional purine biosynthesis protein purh
F8M42_RS13510	COG0357	Ribosomal RNA small subunit methyltransferase G
F8M42_RS13515	COG0445	tRNA wobble uridine modification
F8M42_RS13520	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
F8M42_RS13525	COG1847	R3H domain protein
F8M42_RS13530	COG0706	membrane insertase activity
F8M42_RS13535	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
F8M42_RS13540	COG0594	ribonuclease P activity
F8M42_RS13545	COG0230	Belongs to the bacterial ribosomal protein bL34 family