locus-tag	class	description
CVS35_RS00005	COG0716	FMN binding
CVS35_RS00010	COG1522	sequence-specific DNA binding
CVS35_RS00015	COG2502	aspartate--ammonia ligase
CVS35_RS00020	COG2425	protein containing a von Willebrand factor type A (vWA) domain
CVS35_RS00025	COG0714	Associated with various cellular activities
CVS35_RS00030	COG3158	transport of potassium into the cell
CVS35_RS00035	COG0642	Histidine kinase
CVS35_RS00045	COG3111	PFAM Bacterial OB fold (BOF) protein
CVS35_RS00050	COG1869	D-ribose catabolic process
CVS35_RS00055	COG1129	ABC transporter
CVS35_RS00060	COG1172	Belongs to the binding-protein-dependent transport system permease family
CVS35_RS00075	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CVS35_RS00080	COG1609	Transcriptional regulator
CVS35_RS00105	COG1763	Mo-molybdopterin cofactor biosynthetic process
CVS35_RS00110	COG0746	molybdenum cofactor guanylyltransferase activity
CVS35_RS00115	COG3084	Protein conserved in bacteria
CVS35_RS00120	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CVS35_RS00130	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CVS35_RS00130	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CVS35_RS00135	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CVS35_RS00145	COG3078	GTPase activator activity
CVS35_RS00150	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CVS35_RS00160	COG3852	Histidine kinase
CVS35_RS00175	COG1011	Hydrolase
CVS35_RS00180	COG1490	D-aminoacyl-tRNA deacylase activity
CVS35_RS00185	COG0456	acetyltransferase
CVS35_RS00190	COG2982	Protein involved in outer membrane biogenesis
CVS35_RS00195	COG2233	PERMEase
CVS35_RS00200	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CVS35_RS00205	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CVS35_RS00210	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CVS35_RS00215	COG1758	RNA polymerase activity
CVS35_RS00220	COG0194	GDP metabolic process
CVS35_RS00230	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CVS35_RS00235	COG2194	sulfuric ester hydrolase activity
CVS35_RS00255	COG2200	EAL domain
CVS35_RS00260	COG2081	HI0933 family
CVS35_RS00265	COG0306	phosphate transporter
CVS35_RS00275	COG0589	response to stress
CVS35_RS00280	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CVS35_RS00290	COG0737	Belongs to the 5'-nucleotidase family
CVS35_RS00295	COG0742	ribosomal rna small subunit methyltransferase
CVS35_RS00305	COG1629	transport
CVS35_RS00310	COG1595	DNA-templated transcription, initiation
CVS35_RS00315	COG3712	iron ion homeostasis
CVS35_RS00330	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CVS35_RS00335	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CVS35_RS00355	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CVS35_RS00360	COG1280	lysine exporter protein (LysE YggA)
CVS35_RS00365	COG3550	peptidyl-serine autophosphorylation
CVS35_RS00370	COG3550	peptidyl-serine autophosphorylation
CVS35_RS00385	COG3479	Phenolic acid decarboxylase
CVS35_RS00400	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CVS35_RS00405	COG4172	Belongs to the ABC transporter superfamily
CVS35_RS00410	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CVS35_RS00415	COG0601	transmembrane transport
CVS35_RS00420	COG4166	transmembrane transport
CVS35_RS00430	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CVS35_RS00435	COG0840	transmembrane signaling receptor activity
CVS35_RS00440	COG0456	acetyltransferase
CVS35_RS00445	COG2818	Glycosylase
CVS35_RS00450	COG0730	response to heat
CVS35_RS00455	COG0752	glycyl-tRNA synthetase alpha subunit
CVS35_RS00460	COG0751	glycine-tRNA ligase activity
CVS35_RS00470	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CVS35_RS00470	COG2213	PTS system mannitol-specific
CVS35_RS00475	COG0246	Mannitol dehydrogenase
CVS35_RS00480	COG3722	fumarate hydratase activity
CVS35_RS00490	COG0840	transmembrane signaling receptor activity
CVS35_RS00495	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CVS35_RS00500	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CVS35_RS00505	COG1012	belongs to the aldehyde dehydrogenase family
CVS35_RS00510	COG3274	enterobacterial common antigen metabolic process
CVS35_RS00515	COG1070	Carbohydrate kinase
CVS35_RS00520	COG2115	Belongs to the xylose isomerase family
CVS35_RS00530	COG4213	ABC transporter substrate-binding protein
CVS35_RS00535	COG1129	ABC transporter
CVS35_RS00540	COG4214	carbohydrate transport
CVS35_RS00545	COG2207	Transcriptional regulator
CVS35_RS00545	COG1609	Transcriptional regulator
CVS35_RS00555	COG0137	argininosuccinate synthase activity
CVS35_RS00560	COG3916	Acyl-homoserine-lactone synthase
CVS35_RS00565	COG2771	luxR family
CVS35_RS00570	COG4677	pectinesterase activity
CVS35_RS00575	COG3136	membrane protein required for alginate biosynthesis
CVS35_RS00580	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CVS35_RS00585	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CVS35_RS00615	COG3239	Fatty acid desaturase
CVS35_RS00630	COG1012	belongs to the aldehyde dehydrogenase family
CVS35_RS00635	COG1304	FMN binding
CVS35_RS00640	COG0628	permease
CVS35_RS00695	COG3423	Transcriptional regulator
CVS35_RS00710	COG3727	T/G mismatch-specific endonuclease activity
CVS35_RS00720	COG1561	YicC-like family, N-terminal region
CVS35_RS00725	COG0583	DNA-binding transcription factor activity
CVS35_RS00730	COG1446	asparaginase
CVS35_RS00745	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CVS35_RS00750	COG0601	transmembrane transport
CVS35_RS00755	COG0747	negative chemotaxis
CVS35_RS00760	COG4172	Belongs to the ABC transporter superfamily
CVS35_RS00765	COG4948	Mandelate Racemase Muconate Lactonizing
CVS35_RS00770	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CVS35_RS00775	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CVS35_RS00780	COG1309	transcriptional regulator
CVS35_RS00785	COG0756	dUTP diphosphatase activity
CVS35_RS00790	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CVS35_RS00795	COG2003	Belongs to the UPF0758 family
CVS35_RS00800	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CVS35_RS00810	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CVS35_RS00815	COG0859	PFAM glycosyl transferase family 9
CVS35_RS00820	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CVS35_RS00825	COG1519	Transferase
CVS35_RS00840	COG3306	glycosyltransferase involved in LPS biosynthesis
CVS35_RS00860	COG0438	transferase activity, transferring glycosyl groups
CVS35_RS00865	COG0859	PFAM glycosyl transferase family 9
CVS35_RS00870	COG3307	-O-antigen
CVS35_RS00875	COG3307	-O-antigen
CVS35_RS00880	COG0859	PFAM glycosyl transferase family 9
CVS35_RS00890	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CVS35_RS00895	COG0156	8-amino-7-oxononanoate synthase activity
CVS35_RS00900	COG1063	alcohol dehydrogenase
CVS35_RS00910	COG2861	carbohydrate metabolic process
CVS35_RS00915	COG4942	peptidase
CVS35_RS00920	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CVS35_RS00925	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
CVS35_RS00930	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CVS35_RS00935	COG1045	serine acetyltransferase
CVS35_RS00945	COG3157	Type VI secretion system effector, Hcp
CVS35_RS00965	COG0583	DNA-binding transcription factor activity
CVS35_RS00970	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CVS35_RS00975	COG0840	transmembrane signaling receptor activity
CVS35_RS00980	COG0840	transmembrane signaling receptor activity
CVS35_RS00985	COG0412	Dienelactone hydrolase
CVS35_RS01000	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CVS35_RS01005	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CVS35_RS01005	COG2190	(PTS) system
CVS35_RS01005	COG1263	PTS System
CVS35_RS01010	COG4948	Mandelate Racemase Muconate Lactonizing
CVS35_RS01015	COG2188	Transcriptional regulator
CVS35_RS01020	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CVS35_RS01025	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CVS35_RS01030	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CVS35_RS01035	COG0165	Argininosuccinate lyase
CVS35_RS01040	COG1322	Protein conserved in bacteria
CVS35_RS01045	COG2226	methyltransferase
CVS35_RS01055	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CVS35_RS01060	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CVS35_RS01065	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CVS35_RS01070	COG0805	protein transport
CVS35_RS01075	COG0084	hydrolase, TatD family'
CVS35_RS01085	COG0250	Participates in transcription elongation, termination and antitermination
CVS35_RS01090	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CVS35_RS01100	COG0183	Belongs to the thiolase family
CVS35_RS01105	COG1024	Enoyl-CoA hydratase
CVS35_RS01105	COG1250	3-hydroxyacyl-CoA dehydrogenase
CVS35_RS01110	COG0006	proline dipeptidase activity
CVS35_RS01115	COG1739	Uncharacterized protein family UPF0029
CVS35_RS01155	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CVS35_RS01160	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CVS35_RS01160	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CVS35_RS01165	COG1072	(Pantothenic acid kinase))
CVS35_RS01195	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CVS35_RS01210	COG0250	Participates in transcription elongation, termination and antitermination
CVS35_RS01215	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CVS35_RS01220	COG0081	regulation of translation
CVS35_RS01225	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CVS35_RS01230	COG0222	ribosome binding
CVS35_RS01235	COG0085	RNA polymerase activity
CVS35_RS01240	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CVS35_RS01245	COG0477	Major facilitator Superfamily
CVS35_RS01250	COG5457	Domain of unknown function (DUF1127)
CVS35_RS01255	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CVS35_RS01260	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CVS35_RS01265	COG2022	thiamine diphosphate biosynthetic process
CVS35_RS01270	COG2104	thiamine diphosphate biosynthetic process
CVS35_RS01275	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CVS35_RS01280	COG0352	thiamine-phosphate diphosphorylase activity
CVS35_RS01285	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CVS35_RS01290	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
CVS35_RS01295	COG2816	NAD+ diphosphatase activity
CVS35_RS01300	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CVS35_RS01305	COG1515	deoxyribonuclease V activity
CVS35_RS01325	COG0151	Belongs to the GarS family
CVS35_RS01330	COG0138	bifunctional purine biosynthesis protein purh
CVS35_RS01360	COG1126	abc transporter atp-binding protein
CVS35_RS01365	COG0765	amino acid transport
CVS35_RS01370	COG4597	amino acid ABC transporter
CVS35_RS01375	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CVS35_RS01380	COG0765	amino acid transport
CVS35_RS01385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CVS35_RS01390	COG1733	regulation of RNA biosynthetic process
CVS35_RS01425	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
CVS35_RS01435	COG3338	carbonate dehydratase activity
CVS35_RS01440	COG2264	protein methyltransferase activity
CVS35_RS01445	COG4145	pantothenate transmembrane transporter activity
CVS35_RS01450	COG3924	membrane
CVS35_RS01460	COG0439	Biotin carboxylase
CVS35_RS01465	COG0511	ligase activity, forming carbon-carbon bonds
CVS35_RS01470	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CVS35_RS01475	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
CVS35_RS01480	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CVS35_RS01485	COG0604	alcohol dehydrogenase
CVS35_RS01495	COG2199	diguanylate cyclase activity
CVS35_RS01495	COG2200	EAL domain
CVS35_RS01500	COG1077	Cell shape determining protein MreB Mrl
CVS35_RS01505	COG1792	Involved in formation and maintenance of cell shape
CVS35_RS01510	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
CVS35_RS01515	COG0424	maF-like protein
CVS35_RS01520	COG1530	ribonuclease E activity
CVS35_RS01525	COG3164	Protein of unknown function
CVS35_RS01530	COG0312	modulator of DNA gyrase
CVS35_RS01545	COG0583	DNA-binding transcription factor activity
CVS35_RS01555	COG1566	PFAM secretion protein HlyD family protein
CVS35_RS01560	COG1289	transmembrane transporter activity
CVS35_RS01570	COG3028	Belongs to the UPF0307 family
CVS35_RS01575	COG0312	modulator of DNA gyrase
CVS35_RS01580	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CVS35_RS01585	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CVS35_RS01590	COG1660	Displays ATPase and GTPase activities
CVS35_RS01595	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CVS35_RS01600	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CVS35_RS01605	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CVS35_RS01610	COG1137	ATPase activity
CVS35_RS01615	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
CVS35_RS01620	COG3117	lipopolysaccharide transmembrane transporter activity
CVS35_RS01625	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
CVS35_RS01630	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CVS35_RS01630	COG0517	IMP dehydrogenase activity
CVS35_RS01635	COG0530	calcium, potassium:sodium antiporter activity
CVS35_RS01640	COG1127	ABC transporter
CVS35_RS01645	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CVS35_RS01650	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CVS35_RS01655	COG2854	intermembrane phospholipid transfer
CVS35_RS01660	COG3113	response to antibiotic
CVS35_RS01665	COG5007	Belongs to the BolA IbaG family
CVS35_RS01670	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CVS35_RS01675	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CVS35_RS01680	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CVS35_RS01685	COG3105	Protein conserved in bacteria
CVS35_RS01690	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CVS35_RS01695	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CVS35_RS01700	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CVS35_RS01705	COG0625	glutathione transferase activity
CVS35_RS01710	COG2969	positive regulation of protein catabolic process
CVS35_RS01720	COG0493	'glutamate synthase
CVS35_RS01725	COG0067	glutamate synthase
CVS35_RS01725	COG0069	glutamate synthase activity
CVS35_RS01725	COG0070	glutamate synthase
CVS35_RS01730	COG1242	4 iron, 4 sulfur cluster binding
CVS35_RS01735	COG5002	protein histidine kinase activity
CVS35_RS01735	COG0784	Response regulator, receiver
CVS35_RS01735	COG2198	Histidine kinase
CVS35_RS01740	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
CVS35_RS01745	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CVS35_RS01755	COG2823	Periplasmic or secreted lipoprotein
CVS35_RS01760	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CVS35_RS01765	COG0792	nuclease activity
CVS35_RS01770	COG3107	peptidoglycan biosynthetic process
CVS35_RS01775	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CVS35_RS01785	COG3384	dioxygenase
CVS35_RS01790	COG0754	glutathionylspermidine amidase activity
CVS35_RS01795	COG5463	Belongs to the UPF0441 family
CVS35_RS01800	COG1538	Outer membrane efflux protein
CVS35_RS01805	COG0494	nUDIX hydrolase
CVS35_RS01810	COG3151	Protein conserved in bacteria
CVS35_RS01820	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CVS35_RS01825	COG3150	esterase
CVS35_RS01830	COG0187	DNA topoisomerase II activity
CVS35_RS01835	COG0583	DNA-binding transcription factor activity
CVS35_RS01840	COG2249	NAD(P)H dehydrogenase (quinone) activity
CVS35_RS01855	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CVS35_RS01855	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CVS35_RS01860	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CVS35_RS01865	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CVS35_RS01865	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CVS35_RS01865	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CVS35_RS01870	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CVS35_RS01870	COG3711	transcriptional antiterminator
CVS35_RS01880	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CVS35_RS01885	COG0204	Acyl-transferase
CVS35_RS01890	COG2132	Multicopper oxidase
CVS35_RS01895	COG2188	Transcriptional regulator
CVS35_RS01905	COG1979	alcohol dehydrogenase
CVS35_RS01910	COG0778	Nitroreductase
CVS35_RS01915	COG2207	Transcriptional regulator
CVS35_RS01940	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CVS35_RS01950	COG0848	biopolymer transport protein
CVS35_RS01985	COG4680	protein conserved in bacteria
CVS35_RS02005	COG2814	Major facilitator Superfamily
CVS35_RS02015	COG3787	Belongs to the UPF0306 family
CVS35_RS02020	COG0702	epimerase
CVS35_RS02030	COG1328	CTP reductase activity
CVS35_RS02050	COG2308	Evidence 4 Homologs of previously reported genes of
CVS35_RS02060	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
CVS35_RS02065	COG0540	Belongs to the ATCase OTCase family
CVS35_RS02070	COG2731	YhcH YjgK YiaL family protein
CVS35_RS02075	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CVS35_RS02095	COG0501	Belongs to the peptidase M48B family
CVS35_RS02100	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CVS35_RS02105	COG0840	transmembrane signaling receptor activity
CVS35_RS02110	COG2831	hemolysin activation secretion protein
CVS35_RS02125	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
CVS35_RS02170	COG0525	valine-tRNA ligase activity
CVS35_RS02175	COG2927	DNA polymerase III (CHI subunit)
CVS35_RS02185	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CVS35_RS02190	COG0795	lipopolysaccharide-transporting ATPase activity
CVS35_RS02195	COG0795	lipopolysaccharide-transporting ATPase activity
CVS35_RS02205	COG2850	peptidyl-arginine hydroxylation
CVS35_RS02225	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CVS35_RS02240	COG0583	DNA-binding transcription factor activity
CVS35_RS02275	COG0840	transmembrane signaling receptor activity
CVS35_RS02285	COG0840	transmembrane signaling receptor activity
CVS35_RS02290	COG3254	rhamnose metabolic process
CVS35_RS02295	COG0235	Class ii aldolase
CVS35_RS02300	COG4806	L-rhamnose isomerase
CVS35_RS02305	COG1070	Carbohydrate kinase
CVS35_RS02310	COG1917	Cupin 2, conserved barrel domain protein
CVS35_RS02310	COG2169	Transcriptional regulator
CVS35_RS02315	COG4977	sequence-specific DNA binding
CVS35_RS02315	COG1917	Cupin 2, conserved barrel domain protein
CVS35_RS02320	COG4115	mRNA cleavage
CVS35_RS02325	COG2161	toxin-antitoxin pair type II binding
CVS35_RS02335	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CVS35_RS02345	COG0747	negative chemotaxis
CVS35_RS02355	COG3477	response to acidic pH
CVS35_RS02370	COG2862	Uncharacterized protein family, UPF0114
CVS35_RS02375	COG2130	NADP-dependent
CVS35_RS02395	COG3157	Type VI secretion system effector, Hcp
CVS35_RS02400	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CVS35_RS02405	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CVS35_RS02410	COG0006	proline dipeptidase activity
CVS35_RS02415	COG3079	Belongs to the UPF0149 family
CVS35_RS02420	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
CVS35_RS02430	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CVS35_RS02445	COG0560	Phosphoserine phosphatase
CVS35_RS02450	COG3726	membrane protein affecting hemolysin expression
CVS35_RS02460	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CVS35_RS02465	COG2823	Periplasmic or secreted lipoprotein
CVS35_RS02470	COG5487	UPF0391 membrane protein
CVS35_RS02480	COG0084	hydrolase, TatD family'
CVS35_RS02485	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CVS35_RS02495	COG4771	TonB-dependent receptor
CVS35_RS02505	COG1169	isochorismate synthase
CVS35_RS02510	COG1021	2,3-dihydroxybenzoate-AMP ligase
CVS35_RS02515	COG1535	isochorismatase
CVS35_RS02515	COG3433	isochorismatase activity
CVS35_RS02520	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CVS35_RS02525	COG1028	Short-chain dehydrogenase reductase Sdr
CVS35_RS02535	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CVS35_RS02555	COG0028	Belongs to the TPP enzyme family
CVS35_RS02555	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
CVS35_RS02560	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CVS35_RS02565	COG3624	Phosphonate C-P lyase system protein PhnG
CVS35_RS02570	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
CVS35_RS02575	COG3626	phosphonate metabolism
CVS35_RS02580	COG3627	carbon phosphorus lyase activity
CVS35_RS02585	COG4107	phosphonate C-P lyase system protein PhnK
CVS35_RS02590	COG4778	phosphonate C-P lyase system protein PhnL
CVS35_RS02595	COG3454	Phosphonate metabolism
CVS35_RS02600	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
CVS35_RS02605	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CVS35_RS02650	COG0438	transferase activity, transferring glycosyl groups
CVS35_RS02665	COG1045	serine acetyltransferase
CVS35_RS02680	COG3423	Transcriptional regulator
CVS35_RS02740	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CVS35_RS02750	COG0629	single-stranded DNA binding
CVS35_RS02800	COG0741	lytic transglycosylase activity
CVS35_RS03040	COG2003	Belongs to the UPF0758 family
CVS35_RS03085	COG0604	alcohol dehydrogenase
CVS35_RS03130	COG0318	PFAM AMP-dependent synthetase and ligase
CVS35_RS03135	COG0583	DNA-binding transcription factor activity
CVS35_RS03175	COG1309	transcriptional regulator
CVS35_RS03180	COG4232	protein-disulfide reductase activity
CVS35_RS03185	COG1324	tolerance protein
CVS35_RS03190	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CVS35_RS03205	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CVS35_RS03210	COG0459	protein refolding
CVS35_RS03215	COG3161	chorismate lyase activity
CVS35_RS03220	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CVS35_RS03225	COG2937	Belongs to the GPAT DAPAT family
CVS35_RS03230	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CVS35_RS03235	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CVS35_RS03240	COG3237	CsbD-like
CVS35_RS03245	COG0735	belongs to the Fur family
CVS35_RS03250	COG1741	Belongs to the pirin family
CVS35_RS03255	COG0583	DNA-binding transcription factor activity
CVS35_RS03260	COG0435	Glutathione S-transferase
CVS35_RS03265	COG2259	Doxx family
CVS35_RS03275	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
CVS35_RS03280	COG4575	ribosome binding
CVS35_RS03285	COG1422	Protein of unknown function (DUF1090)
CVS35_RS03295	COG0586	Pfam SNARE associated Golgi protein
CVS35_RS03305	COG2271	Major facilitator Superfamily
CVS35_RS03310	COG1904	glucuronate isomerase
CVS35_RS03315	COG0246	Mannitol dehydrogenase
CVS35_RS03320	COG2721	sulfolactate sulfo-lyase activity
CVS35_RS03330	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CVS35_RS03345	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
CVS35_RS03350	COG0861	Integral membrane protein TerC family
CVS35_RS03355	COG0673	inositol 2-dehydrogenase activity
CVS35_RS03360	COG2813	Specifically methylates the guanine in position
CVS35_RS03365	COG1902	pentaerythritol trinitrate reductase activity
CVS35_RS03365	COG0446	pyridine nucleotide-disulphide oxidoreductase
CVS35_RS03375	COG3678	ATP-independent chaperone mediated protein folding
CVS35_RS03380	COG2199	diguanylate cyclase activity
CVS35_RS03415	COG3663	DNA glycosylase
CVS35_RS03425	COG0358	DNA primase activity
CVS35_RS03430	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CVS35_RS03440	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CVS35_RS03445	COG1438	arginine binding
CVS35_RS03450	COG0039	L-malate dehydrogenase activity
CVS35_RS03455	COG3423	Transcriptional regulator
CVS35_RS03470	COG0142	geranyltranstransferase activity
CVS35_RS03475	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CVS35_RS03480	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CVS35_RS03485	COG0697	spore germination
CVS35_RS03490	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CVS35_RS03495	COG2027	D-alanyl-D-alanine carboxypeptidase
CVS35_RS03505	COG1534	Rna-binding protein
CVS35_RS03510	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CVS35_RS03515	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CVS35_RS03520	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CVS35_RS03525	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CVS35_RS03535	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CVS35_RS03585	COG0779	Required for maturation of 30S ribosomal subunits
CVS35_RS03595	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CVS35_RS03600	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CVS35_RS03605	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CVS35_RS03610	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CVS35_RS03615	COG1185	polyribonucleotide nucleotidyltransferase activity
CVS35_RS03630	COG0513	Belongs to the DEAD box helicase family
CVS35_RS03635	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CVS35_RS03640	COG0826	peptidase U32
CVS35_RS03645	COG0826	peptidase U32
CVS35_RS03650	COG3154	lipid carrier protein
CVS35_RS03655	COG3153	acetyltransferase
CVS35_RS03660	COG2827	Endonuclease containing a URI domain
CVS35_RS03665	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CVS35_RS03670	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
CVS35_RS03675	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CVS35_RS03680	COG0813	purine-nucleoside phosphorylase activity
CVS35_RS03700	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
CVS35_RS03705	COG2813	Specifically methylates the guanine in position
CVS35_RS03710	COG0667	Aldo Keto reductase
CVS35_RS03755	COG1454	alcohol dehydrogenase
CVS35_RS03760	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CVS35_RS03765	COG0509	glycine decarboxylation via glycine cleavage system
CVS35_RS03770	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CVS35_RS03770	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CVS35_RS03775	COG1733	regulation of RNA biosynthetic process
CVS35_RS03780	COG1028	Short-chain dehydrogenase reductase Sdr
CVS35_RS03785	COG1175	transmembrane transport
CVS35_RS03795	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CVS35_RS03805	COG1653	transport
CVS35_RS03810	COG2211	Major facilitator Superfamily
CVS35_RS03830	COG1272	protein, Hemolysin III
CVS35_RS03835	COG0354	folic acid binding
CVS35_RS03840	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
CVS35_RS03880	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
CVS35_RS03890	COG0716	FMN binding
CVS35_RS03915	COG0477	Major facilitator Superfamily
CVS35_RS03920	COG4974	Belongs to the 'phage' integrase family
CVS35_RS03925	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CVS35_RS03930	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CVS35_RS03940	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CVS35_RS03970	COG4319	ketosteroid isomerase
CVS35_RS03980	COG1560	Kdo2-lipid A biosynthetic process
CVS35_RS03990	COG2252	PERMEase
CVS35_RS03995	COG0025	NhaP-type Na H and K H
CVS35_RS04005	COG3850	Histidine kinase
CVS35_RS04005	COG5002	protein histidine kinase activity
CVS35_RS04025	COG4964	Belongs to the GSP D family
CVS35_RS04105	COG5464	transposase or invertase
CVS35_RS04110	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CVS35_RS04115	COG3162	membrane
CVS35_RS04120	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CVS35_RS04130	COG4774	siderophore transport
CVS35_RS04145	COG3712	iron ion homeostasis
CVS35_RS04170	COG0246	Mannitol dehydrogenase
CVS35_RS04175	COG2873	o-acetylhomoserine
CVS35_RS04180	COG1376	ErfK ybiS ycfS ynhG family protein
CVS35_RS04185	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CVS35_RS04190	COG3038	cytochrome b561
CVS35_RS04195	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CVS35_RS04195	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CVS35_RS04195	COG1013	pyruvate-flavodoxin oxidoreductase activity
CVS35_RS04195	COG0674	pyruvate-flavodoxin oxidoreductase activity
CVS35_RS04215	COG1280	lysine exporter protein (LysE YggA)
CVS35_RS04220	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CVS35_RS04255	COG2026	Addiction module toxin, RelE StbE family
CVS35_RS04320	COG0582	viral genome integration into host DNA
CVS35_RS04380	COG0582	viral genome integration into host DNA
CVS35_RS04390	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CVS35_RS04395	COG2867	negative regulation of translational initiation
CVS35_RS04400	COG2914	Belongs to the UPF0125 (RnfH) family
CVS35_RS04410	COG0497	DNA recombination
CVS35_RS04415	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CVS35_RS04420	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CVS35_RS04425	COG1914	H( )-stimulated, divalent metal cation uptake system
CVS35_RS04430	COG1942	4-Oxalocrotonate Tautomerase
CVS35_RS04435	COG0477	Major facilitator Superfamily
CVS35_RS04445	COG0494	nUDIX hydrolase
CVS35_RS04475	COG1609	Transcriptional regulator
CVS35_RS04480	COG1126	abc transporter atp-binding protein
CVS35_RS04485	COG0765	amino acid transport
CVS35_RS04495	COG3711	transcriptional antiterminator
CVS35_RS04500	COG2723	6-phospho-beta-galactosidase activity
CVS35_RS04505	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CVS35_RS04505	COG2190	(PTS) system
CVS35_RS04505	COG1263	PTS System
CVS35_RS04515	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CVS35_RS04520	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CVS35_RS04525	COG0698	ribose 5-phosphate isomerase
CVS35_RS04540	COG2376	Dihydroxyacetone kinase
CVS35_RS04545	COG0149	triose-phosphate isomerase activity
CVS35_RS04555	COG2084	Dehydrogenase
CVS35_RS04570	COG0814	amino acid
CVS35_RS04575	COG1671	Belongs to the UPF0178 family
CVS35_RS04580	COG0408	coproporphyrinogen oxidase activity
CVS35_RS04585	COG0456	acetyltransferase
CVS35_RS04595	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
CVS35_RS04605	COG0612	Peptidase, M16
CVS35_RS04610	COG4178	(ABC) transporter
CVS35_RS04620	COG2837	iron assimilation
CVS35_RS04625	COG4150	thiosulfate binding
CVS35_RS04630	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CVS35_RS04635	COG4208	sulfate ABC transporter
CVS35_RS04640	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CVS35_RS04645	COG0577	efflux transmembrane transporter activity
CVS35_RS04645	COG1136	(ABC) transporter
CVS35_RS04650	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CVS35_RS04655	COG0745	RESPONSE REGULATOR receiver
CVS35_RS04660	COG2205	protein histidine kinase activity
CVS35_RS04665	COG2190	(PTS) system
CVS35_RS04675	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CVS35_RS04685	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
CVS35_RS04690	COG3115	cell septum assembly
CVS35_RS04695	COG0531	amino acid
CVS35_RS04705	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CVS35_RS04715	COG0446	pyridine nucleotide-disulphide oxidoreductase
CVS35_RS04720	COG0426	domain, Protein
CVS35_RS04720	COG1773	rubredoxin
CVS35_RS04725	COG3604	Transcriptional regulator
CVS35_RS04730	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
CVS35_RS04730	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
CVS35_RS04735	COG0583	DNA-binding transcription factor activity
CVS35_RS04755	COG2169	Transcriptional regulator
CVS35_RS04755	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CVS35_RS04760	COG3145	DNA-N1-methyladenine dioxygenase activity
CVS35_RS04770	COG0431	NADPH-dependent FMN reductase
CVS35_RS04770	COG1053	succinate dehydrogenase
CVS35_RS04770	COG3976	FMN-binding domain protein
CVS35_RS04775	COG0477	Major facilitator Superfamily
CVS35_RS04780	COG3301	Polysulphide reductase, NrfD
CVS35_RS04785	COG0437	4 iron, 4 sulfur cluster binding
CVS35_RS04795	COG0583	DNA-binding transcription factor activity
CVS35_RS04800	COG4948	Mandelate Racemase Muconate Lactonizing
CVS35_RS04805	COG1063	alcohol dehydrogenase
CVS35_RS04810	COG0477	Major facilitator Superfamily
CVS35_RS04815	COG0246	Mannitol dehydrogenase
CVS35_RS04820	COG1802	Transcriptional regulator
CVS35_RS04825	COG0583	DNA-binding transcription factor activity
CVS35_RS04845	COG0811	peptide transport
CVS35_RS04865	COG2814	Major facilitator Superfamily
CVS35_RS04890	COG4773	Receptor
CVS35_RS04895	COG4948	Mandelate Racemase Muconate Lactonizing
CVS35_RS04920	COG3121	Chaperone
CVS35_RS04965	COG1309	transcriptional regulator
CVS35_RS04970	COG2249	NAD(P)H dehydrogenase (quinone) activity
CVS35_RS05045	COG3423	Transcriptional regulator
CVS35_RS05055	COG1982	Orn Lys Arg decarboxylase major
CVS35_RS05070	COG5441	Belongs to the UPF0261 family
CVS35_RS05075	COG5564	TIM-barrel signal transduction protein
CVS35_RS05085	COG1917	Cupin 2, conserved barrel domain protein
CVS35_RS05085	COG2169	Transcriptional regulator
CVS35_RS05090	COG0741	lytic transglycosylase activity
CVS35_RS05095	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
CVS35_RS05105	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CVS35_RS05110	COG3171	Protein conserved in bacteria
CVS35_RS05125	COG0667	Aldo Keto reductase
CVS35_RS05140	COG0861	Integral membrane protein TerC family
CVS35_RS05145	COG3066	DNA modification
CVS35_RS05150	COG0494	nUDIX hydrolase
CVS35_RS05160	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CVS35_RS05165	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CVS35_RS05175	COG4795	General secretion pathway protein
CVS35_RS05190	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
CVS35_RS05195	COG1025	Belongs to the peptidase M16 family
CVS35_RS05200	COG1074	ATP-dependent DNA helicase activity
CVS35_RS05205	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CVS35_RS05210	COG1609	Transcriptional regulator
CVS35_RS05220	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CVS35_RS05220	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CVS35_RS05225	COG0860	N-Acetylmuramoyl-L-alanine amidase
CVS35_RS05245	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
CVS35_RS05250	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CVS35_RS05260	COG1473	amidohydrolase
CVS35_RS05265	COG4172	Belongs to the ABC transporter superfamily
CVS35_RS05270	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CVS35_RS05280	COG0747	negative chemotaxis
CVS35_RS05290	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CVS35_RS05295	COG2166	iron-sulfur cluster assembly
CVS35_RS05300	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CVS35_RS05310	COG0583	DNA-binding transcription factor activity
CVS35_RS05315	COG2363	Small membrane protein
CVS35_RS05320	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
CVS35_RS05325	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CVS35_RS05330	COG1611	Belongs to the LOG family
CVS35_RS05335	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CVS35_RS05335	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CVS35_RS05375	COG2171	N-acyltransferase activity
CVS35_RS05380	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CVS35_RS05390	COG0052	Belongs to the universal ribosomal protein uS2 family
CVS35_RS05395	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CVS35_RS05400	COG0528	UMP kinase activity
CVS35_RS05405	COG0233	cytoplasmic translational termination
CVS35_RS05410	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CVS35_RS05415	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CVS35_RS05420	COG0575	Belongs to the CDS family
CVS35_RS05425	COG0750	zinc metalloprotease
CVS35_RS05430	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CVS35_RS05435	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
CVS35_RS05440	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CVS35_RS05445	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CVS35_RS05450	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CVS35_RS05455	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CVS35_RS05460	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CVS35_RS05465	COG0587	DNA-directed DNA polymerase activity
CVS35_RS05470	COG0825	malonyl-CoA metabolic process
CVS35_RS05475	COG0346	lactoylglutathione lyase activity
CVS35_RS05480	COG0037	tRNA processing
CVS35_RS05485	COG4568	rho-dependent transcription termination
CVS35_RS05500	COG3015	lipoprotein NlpE involved in copper resistance
CVS35_RS05505	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CVS35_RS05520	COG1204	response to ionizing radiation
CVS35_RS05575	COG0514	ATP-dependent DNA helicase (RecQ)
CVS35_RS05595	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CVS35_RS05610	COG1120	ATPase activity
CVS35_RS05615	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CVS35_RS05620	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CVS35_RS05625	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
CVS35_RS05630	COG4772	TonB-dependent receptor
CVS35_RS05635	COG3712	iron ion homeostasis
CVS35_RS05640	COG1595	DNA-templated transcription, initiation
CVS35_RS05645	COG4943	cyclic-guanylate-specific phosphodiesterase activity
CVS35_RS05650	COG2824	Alkylphosphonate utilization operon protein PhnA
CVS35_RS05655	COG2951	lytic endotransglycosylase activity
CVS35_RS05665	COG0583	DNA-binding transcription factor activity
CVS35_RS05695	COG2186	Transcriptional regulator
CVS35_RS05700	COG1312	Catalyzes the dehydration of D-mannonate
CVS35_RS05705	COG5297	Belongs to the glycosyl hydrolase family 6
CVS35_RS05710	COG5434	Belongs to the glycosyl hydrolase 28 family
CVS35_RS05720	COG1132	(ABC) transporter
CVS35_RS05735	COG4615	Cyclic peptide transporter
CVS35_RS05745	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CVS35_RS05750	COG3123	guanosine phosphorylase activity
CVS35_RS05760	COG2974	May be involved in recombination
CVS35_RS05770	COG1940	carbohydrate kinase activity
CVS35_RS05775	COG0419	ATPase involved in DNA repair
CVS35_RS05780	COG0420	3'-5' exonuclease activity
CVS35_RS05805	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CVS35_RS05815	COG1113	amino acid transport
CVS35_RS05820	COG0668	transmembrane transport
CVS35_RS05825	COG0450	alkyl hydroperoxide reductase
CVS35_RS05830	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
CVS35_RS05840	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CVS35_RS05845	COG0343	queuine tRNA-ribosyltransferase activity
CVS35_RS05850	COG1862	Preprotein translocase
CVS35_RS05855	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CVS35_RS05860	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CVS35_RS05865	COG4238	major outer membrane lipoprotein
CVS35_RS05875	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CVS35_RS05880	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CVS35_RS05880	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CVS35_RS05885	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CVS35_RS05890	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CVS35_RS05895	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CVS35_RS05900	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CVS35_RS05905	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CVS35_RS05910	COG0142	geranyltranstransferase activity
CVS35_RS05915	COG1722	exodeoxyribonuclease VII activity
CVS35_RS05920	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CVS35_RS05920	COG0301	tRNA thio-modification
CVS35_RS05925	COG0693	protein deglycase activity
CVS35_RS05930	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CVS35_RS05935	COG1666	GTP binding
CVS35_RS05940	COG2814	Major facilitator Superfamily
CVS35_RS05945	COG0109	protoheme IX farnesyltransferase activity
CVS35_RS05950	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CVS35_RS05955	COG1845	cytochrome c oxidase, subunit III
CVS35_RS05960	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CVS35_RS05965	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CVS35_RS05970	COG2223	nitrite transmembrane transporter activity
CVS35_RS05975	COG3056	Lipoprotein
CVS35_RS05980	COG0271	Belongs to the BolA IbaG family
CVS35_RS05985	COG0544	peptidyl-prolyl cis-trans isomerase activity
CVS35_RS05990	COG0740	serine-type endopeptidase activity
CVS35_RS05995	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CVS35_RS06000	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CVS35_RS06005	COG0776	regulation of translation
CVS35_RS06010	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CVS35_RS06015	COG1555	photosystem II stabilization
CVS35_RS06020	COG0824	Thioesterase
CVS35_RS06025	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CVS35_RS06030	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CVS35_RS06035	COG1522	sequence-specific DNA binding
CVS35_RS06040	COG1132	(ABC) transporter
CVS35_RS06045	COG1132	(ABC) transporter
CVS35_RS06050	COG0347	Belongs to the P(II) protein family
CVS35_RS06055	COG0004	ammonium transporteR
CVS35_RS06060	COG1946	Acyl-CoA thioesterase
CVS35_RS06065	COG3126	Type III secretion system lipoprotein chaperone (YscW)
CVS35_RS06070	COG3695	enzyme binding
CVS35_RS06090	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CVS35_RS06095	COG0254	rRNA binding
CVS35_RS06100	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CVS35_RS06105	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CVS35_RS06110	COG1309	transcriptional regulator
CVS35_RS06125	COG2832	Protein of unknown function (DUF454)
CVS35_RS06130	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CVS35_RS06135	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CVS35_RS06140	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CVS35_RS06145	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CVS35_RS06150	COG0326	Molecular chaperone. Has ATPase activity
CVS35_RS06155	COG0563	adenylate kinase activity
CVS35_RS06160	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CVS35_RS06165	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CVS35_RS06165	COG4651	solute:proton antiporter activity
CVS35_RS06170	COG0737	Belongs to the 5'-nucleotidase family
CVS35_RS06185	COG1966	Carbon starvation protein
CVS35_RS06190	COG2879	small protein
CVS35_RS06195	COG0523	cobalamin synthesis protein
CVS35_RS06200	COG5434	Belongs to the glycosyl hydrolase 28 family
CVS35_RS06210	COG3735	TraB family
CVS35_RS06215	COG2217	Heavy metal translocating P-type atpase
CVS35_RS06225	COG1585	Membrane protein implicated in regulation of membrane protease activity
CVS35_RS06230	COG0330	HflC and HflK could
CVS35_RS06235	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CVS35_RS06240	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CVS35_RS06245	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CVS35_RS06250	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CVS35_RS06260	COG0784	Response regulator, receiver
CVS35_RS06260	COG2205	protein histidine kinase activity
CVS35_RS06265	COG2197	response regulator
CVS35_RS06270	COG0642	Histidine kinase
CVS35_RS06270	COG2198	Histidine kinase
CVS35_RS06275	COG2223	nitrite transmembrane transporter activity
CVS35_RS06280	COG1733	regulation of RNA biosynthetic process
CVS35_RS06285	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
CVS35_RS06290	COG1028	Short-chain dehydrogenase reductase Sdr
CVS35_RS06295	COG1028	Short-chain dehydrogenase reductase Sdr
CVS35_RS06300	COG1169	isochorismate synthase
CVS35_RS06305	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CVS35_RS06310	COG0596	Alpha beta hydrolase
CVS35_RS06315	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CVS35_RS06320	COG1441	menaquinone biosynthetic process
CVS35_RS06340	COG0814	amino acid
CVS35_RS06350	COG3118	belongs to the thioredoxin family
CVS35_RS06355	COG0300	oxidoreductase activity
CVS35_RS06360	COG2755	lipolytic protein G-D-S-L family
CVS35_RS06365	COG4181	ATPase activity
CVS35_RS06370	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
CVS35_RS06375	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
CVS35_RS06380	COG0437	4 iron, 4 sulfur cluster binding
CVS35_RS06385	COG5557	Pfam Polysulphide reductase, NrfD
CVS35_RS06390	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
CVS35_RS06395	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CVS35_RS06400	COG1773	rubredoxin
CVS35_RS06405	COG0309	Hydrogenase expression formation protein (HypE)
CVS35_RS06410	COG0409	Hydrogenase expression formation protein
CVS35_RS06415	COG0298	carbon dioxide binding
CVS35_RS06420	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CVS35_RS06425	COG0375	protein maturation
CVS35_RS06430	COG3604	Transcriptional regulator
CVS35_RS06435	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CVS35_RS06445	COG3260	NADH ubiquinone oxidoreductase 20
CVS35_RS06450	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CVS35_RS06455	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
CVS35_RS06455	COG3261	NADH dehydrogenase
CVS35_RS06460	COG0651	ATP synthesis coupled electron transport
CVS35_RS06465	COG4237	Hydrogenase 4 membrane
CVS35_RS06470	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CVS35_RS06475	COG0650	Formate hydrogenlyase subunit 4
CVS35_RS06480	COG0651	ATP synthesis coupled electron transport
CVS35_RS06485	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CVS35_RS06490	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CVS35_RS06495	COG3383	formate dehydrogenase (NAD+) activity
CVS35_RS06500	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
CVS35_RS06505	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
CVS35_RS06510	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CVS35_RS06515	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CVS35_RS06520	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CVS35_RS06525	COG2233	PERMEase
CVS35_RS06530	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CVS35_RS06535	COG1393	Belongs to the ArsC family
CVS35_RS06540	COG4783	chaperone-mediated protein folding
CVS35_RS06545	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CVS35_RS06550	COG2716	regulation of RNA biosynthetic process
CVS35_RS06560	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
CVS35_RS06565	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CVS35_RS06570	COG2707	UPF0756 membrane protein
CVS35_RS06575	COG1444	tRNA N-acetyltransferase activity
CVS35_RS06580	COG3118	belongs to the thioredoxin family
CVS35_RS06585	COG0312	modulator of DNA gyrase
CVS35_RS06590	COG0312	modulator of DNA gyrase
CVS35_RS06605	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
CVS35_RS06610	COG3712	iron ion homeostasis
CVS35_RS06615	COG1595	DNA-templated transcription, initiation
CVS35_RS06625	COG4774	siderophore transport
CVS35_RS06630	COG4178	(ABC) transporter
CVS35_RS06645	COG3813	Protein conserved in bacteria
CVS35_RS06650	COG0400	carboxylic ester hydrolase activity
CVS35_RS06660	COG0183	Belongs to the thiolase family
CVS35_RS06665	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CVS35_RS06670	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CVS35_RS06685	COG2851	Citrate transporter
CVS35_RS06690	COG0583	DNA-binding transcription factor activity
CVS35_RS06700	COG1876	peptidase activity
CVS35_RS06705	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CVS35_RS06710	COG1393	Belongs to the ArsC family
CVS35_RS06715	COG1794	racemase activity, acting on amino acids and derivatives
CVS35_RS06725	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CVS35_RS06730	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CVS35_RS06735	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CVS35_RS06740	COG0321	lipoyl(octanoyl) transferase activity
CVS35_RS06745	COG2921	Belongs to the UPF0250 family
CVS35_RS06750	COG1686	Belongs to the peptidase S11 family
CVS35_RS06755	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CVS35_RS06760	COG0772	Belongs to the SEDS family
CVS35_RS06765	COG0768	penicillin binding
CVS35_RS06770	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CVS35_RS06775	COG0799	negative regulation of ribosome biogenesis
CVS35_RS06780	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CVS35_RS06785	COG1466	dna polymerase III delta subunit
CVS35_RS06790	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
CVS35_RS06795	COG0495	leucyl-tRNA aminoacylation
CVS35_RS06800	COG2888	peptidyl-tyrosine sulfation
CVS35_RS06805	COG1126	abc transporter atp-binding protein
CVS35_RS06810	COG0765	amino acid transport
CVS35_RS06815	COG0765	amino acid transport
CVS35_RS06825	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CVS35_RS06835	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CVS35_RS06840	COG1702	phosphate starvation-inducible protein PhoH
CVS35_RS06845	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CVS35_RS06850	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CVS35_RS06900	COG0367	asparagine synthase
CVS35_RS06905	COG1940	carbohydrate kinase activity
CVS35_RS06905	COG1846	Transcriptional regulator
CVS35_RS06910	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CVS35_RS06915	COG0363	glucosamine-6-phosphate deaminase activity
CVS35_RS06920	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CVS35_RS06920	COG2190	(PTS) system
CVS35_RS06920	COG1263	PTS System
CVS35_RS06925	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CVS35_RS06930	COG0735	belongs to the Fur family
CVS35_RS06940	COG0840	transmembrane signaling receptor activity
CVS35_RS06950	COG0596	Alpha beta hydrolase
CVS35_RS06955	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
CVS35_RS06960	COG0033	Phosphoglucomutase
CVS35_RS06970	COG0745	RESPONSE REGULATOR receiver
CVS35_RS06975	COG2205	protein histidine kinase activity
CVS35_RS06985	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CVS35_RS06995	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
CVS35_RS07015	COG1840	ABC-type Fe3 transport system, periplasmic component
CVS35_RS07020	COG3842	ATPase activity
CVS35_RS07025	COG3272	Protein of unknown function (DUF1722)
CVS35_RS07030	COG0415	Belongs to the DNA photolyase family
CVS35_RS07035	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CVS35_RS07040	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CVS35_RS07045	COG1984	allophanate hydrolase subunit 2
CVS35_RS07050	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CVS35_RS07055	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
CVS35_RS07060	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CVS35_RS07075	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
CVS35_RS07080	COG1053	succinate dehydrogenase
CVS35_RS07085	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CVS35_RS07090	COG0567	Dehydrogenase, E1 component
CVS35_RS07095	COG0508	dehydrogenase complex catalyzes the overall conversion of
CVS35_RS07100	COG0045	succinate-CoA ligase (ADP-forming) activity
CVS35_RS07105	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CVS35_RS07110	COG1271	oxidase subunit
CVS35_RS07115	COG1294	oxidase, subunit
CVS35_RS07120	COG4890	Cyd operon protein YbgT
CVS35_RS07125	COG3790	cyd operon protein YbgE
CVS35_RS07130	COG0824	Thioesterase
CVS35_RS07135	COG0811	peptide transport
CVS35_RS07140	COG0848	biopolymer transport protein
CVS35_RS07145	COG3064	Membrane
CVS35_RS07150	COG0823	Involved in the tonB-independent uptake of proteins
CVS35_RS07155	COG2885	chlorophyll binding
CVS35_RS07160	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
CVS35_RS07185	COG1811	Na channel or pump
CVS35_RS07195	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CVS35_RS07205	COG1230	cation diffusion facilitator family transporter
CVS35_RS07210	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CVS35_RS07215	COG0588	phosphoglycerate mutase activity
CVS35_RS07220	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CVS35_RS07225	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CVS35_RS07245	COG2017	converts alpha-aldose to the beta-anomer
CVS35_RS07250	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CVS35_RS07255	COG1119	ATPase activity
CVS35_RS07260	COG3585	molybdate ion transport
CVS35_RS07260	COG2005	Transcriptional regulator
CVS35_RS07270	COG0725	ABC transporter, periplasmic molybdate-binding protein
CVS35_RS07275	COG4149	molybdate abc transporter
CVS35_RS07280	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
CVS35_RS07290	COG1609	Transcriptional regulator
CVS35_RS07305	COG2211	Major facilitator Superfamily
CVS35_RS07310	COG0837	glucose binding
CVS35_RS07315	COG0561	phosphatase activity
CVS35_RS07325	COG2706	6-phosphogluconolactonase activity
CVS35_RS07340	COG2864	formate dehydrogenase
CVS35_RS07345	COG0437	4 iron, 4 sulfur cluster binding
CVS35_RS07350	COG0243	molybdopterin cofactor binding
CVS35_RS07350	COG3383	formate dehydrogenase (NAD+) activity
CVS35_RS07355	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CVS35_RS07355	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CVS35_RS07360	COG0489	protein tyrosine kinase activity
CVS35_RS07365	COG0572	uridine kinase
CVS35_RS07370	COG0717	Belongs to the dCTP deaminase family
CVS35_RS07375	COG2982	Protein involved in outer membrane biogenesis
CVS35_RS07380	COG3069	C4-dicarboxylate transmembrane transporter activity
CVS35_RS07385	COG1253	flavin adenine dinucleotide binding
CVS35_RS07390	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CVS35_RS07405	COG0489	protein tyrosine kinase activity
CVS35_RS07405	COG3206	protein involved in exopolysaccharide biosynthesis
CVS35_RS07420	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CVS35_RS07440	COG0028	Belongs to the TPP enzyme family
CVS35_RS07450	COG4569	acetaldehyde dehydrogenase (acetylating) activity
CVS35_RS07455	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CVS35_RS07465	COG2244	polysaccharide biosynthetic process
CVS35_RS07550	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CVS35_RS07555	COG1605	Chorismate mutase
CVS35_RS07565	COG2723	6-phospho-beta-galactosidase activity
CVS35_RS07570	COG3711	transcriptional antiterminator
CVS35_RS07575	COG3706	GGDEF domain
CVS35_RS07595	COG3962	Belongs to the TPP enzyme family
CVS35_RS07605	COG0673	inositol 2-dehydrogenase activity
CVS35_RS07620	COG1172	Belongs to the binding-protein-dependent transport system permease family
CVS35_RS07640	COG3718	enzyme involved in inositol metabolism
CVS35_RS07645	COG3842	ATPase activity
CVS35_RS07650	COG4208	sulfate ABC transporter
CVS35_RS07655	COG1840	ABC-type Fe3 transport system, periplasmic component
CVS35_RS07670	COG3615	Tellurite resistance protein tehB
CVS35_RS07690	COG2207	Transcriptional regulator
CVS35_RS07695	COG0583	DNA-binding transcription factor activity
CVS35_RS07700	COG0604	alcohol dehydrogenase
CVS35_RS07710	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CVS35_RS07760	COG2223	nitrite transmembrane transporter activity
CVS35_RS07765	COG3250	beta-galactosidase activity
CVS35_RS07770	COG1609	Transcriptional regulator
CVS35_RS07775	COG3842	ATPase activity
CVS35_RS07785	COG1840	ABC-type Fe3 transport system, periplasmic component
CVS35_RS07790	COG2271	Major facilitator Superfamily
CVS35_RS07805	COG1464	Belongs to the NlpA lipoprotein family
CVS35_RS07820	COG0583	DNA-binding transcription factor activity
CVS35_RS07825	COG1301	dicarboxylic acid transport
CVS35_RS07835	COG2851	Citrate transporter
CVS35_RS07840	COG3383	formate dehydrogenase (NAD+) activity
CVS35_RS07845	COG0840	transmembrane signaling receptor activity
CVS35_RS07850	COG0672	)-iron permease
CVS35_RS07865	COG1136	(ABC) transporter
CVS35_RS07865	COG0577	efflux transmembrane transporter activity
CVS35_RS07875	COG0577	efflux transmembrane transporter activity
CVS35_RS07875	COG1136	(ABC) transporter
CVS35_RS07880	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CVS35_RS07885	COG0697	spore germination
CVS35_RS07900	COG1301	dicarboxylic acid transport
CVS35_RS07915	COG0371	Dehydrogenase
CVS35_RS07920	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CVS35_RS07925	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
CVS35_RS07935	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
CVS35_RS07945	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CVS35_RS07950	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
CVS35_RS07955	COG2515	1-aminocyclopropane-1-carboxylate deaminase
CVS35_RS07965	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CVS35_RS08005	COG1012	belongs to the aldehyde dehydrogenase family
CVS35_RS08010	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CVS35_RS08025	COG0477	Major facilitator Superfamily
CVS35_RS08030	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CVS35_RS08035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CVS35_RS08040	COG0747	negative chemotaxis
CVS35_RS08055	COG0444	Belongs to the ABC transporter superfamily
CVS35_RS08075	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CVS35_RS08110	COG3008	intermembrane lipid transfer
CVS35_RS08110	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CVS35_RS08115	COG2995	paraquat-inducible protein a
CVS35_RS08130	COG0784	Response regulator, receiver
CVS35_RS08130	COG0835	chemotaxis
CVS35_RS08135	COG0625	glutathione transferase activity
CVS35_RS08140	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CVS35_RS08145	COG0640	Transcriptional regulator
CVS35_RS08150	COG2814	Major facilitator Superfamily
CVS35_RS08155	COG2814	Major facilitator Superfamily
CVS35_RS08160	COG4978	Transcriptional regulator
CVS35_RS08160	COG0789	Transcriptional regulator
CVS35_RS08170	COG3122	Protein conserved in bacteria
CVS35_RS08200	COG3046	protein related to deoxyribodipyrimidine photolyase
CVS35_RS08215	COG1028	Short-chain dehydrogenase reductase Sdr
CVS35_RS08230	COG1201	RNA secondary structure unwinding
CVS35_RS08355	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
CVS35_RS08370	COG3736	Type IV secretory pathway, component VirB8
CVS35_RS08445	COG0745	RESPONSE REGULATOR receiver
CVS35_RS08465	COG0582	viral genome integration into host DNA
CVS35_RS08485	COG1113	amino acid transport
CVS35_RS08505	COG2197	response regulator
CVS35_RS08510	COG0322	excinuclease ABC activity
CVS35_RS08515	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CVS35_RS08535	COG0582	viral genome integration into host DNA
CVS35_RS08550	COG0084	hydrolase, TatD family'
CVS35_RS08615	COG3596	GTP binding
CVS35_RS08630	COG2003	Belongs to the UPF0758 family
CVS35_RS08660	COG0583	DNA-binding transcription factor activity
CVS35_RS08680	COG0401	homolog of Blt101
CVS35_RS08685	COG0471	metal ion transport
CVS35_RS08695	COG2188	Transcriptional regulator
CVS35_RS08715	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CVS35_RS08720	COG0303	'Molybdopterin
CVS35_RS08725	COG4172	Belongs to the ABC transporter superfamily
CVS35_RS08730	COG0747	negative chemotaxis
CVS35_RS08735	COG0601	transmembrane transport
CVS35_RS08740	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CVS35_RS08745	COG0281	malic enzyme
CVS35_RS08750	COG0295	cytidine deaminase activity
CVS35_RS08755	COG1346	cytolysis
CVS35_RS08760	COG1380	Effector of murein hydrolase LrgA
CVS35_RS08765	COG5297	Belongs to the glycosyl hydrolase family 6
CVS35_RS08775	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CVS35_RS08780	COG0156	8-amino-7-oxononanoate synthase activity
CVS35_RS08785	COG2226	methyltransferase
CVS35_RS08790	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CVS35_RS08795	COG0556	nucleotide-excision repair
CVS35_RS08810	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CVS35_RS08815	COG0521	Mo-molybdopterin cofactor biosynthetic process
CVS35_RS08820	COG0315	cyclic pyranopterin monophosphate synthase activity
CVS35_RS08825	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
CVS35_RS08830	COG0314	molybdopterin synthase activity
CVS35_RS08835	COG0670	Belongs to the BI1 family
CVS35_RS08850	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CVS35_RS08855	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CVS35_RS08860	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CVS35_RS08865	COG1120	ATPase activity
CVS35_RS08870	COG0513	Belongs to the DEAD box helicase family
CVS35_RS08880	COG5642	Protein of unknown function (DUF2384)
CVS35_RS08885	COG5654	RES domain protein
CVS35_RS08890	COG2195	Cleaves the N-terminal amino acid of tripeptides
CVS35_RS08895	COG0747	negative chemotaxis
CVS35_RS08900	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CVS35_RS08905	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CVS35_RS08910	COG0833	amino acid
CVS35_RS08915	COG2040	homocysteine
CVS35_RS08940	COG1686	Belongs to the peptidase S11 family
CVS35_RS08955	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CVS35_RS09040	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CVS35_RS09050	COG1126	abc transporter atp-binding protein
CVS35_RS09055	COG0765	amino acid transport
CVS35_RS09060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CVS35_RS09065	COG0783	Belongs to the Dps family
CVS35_RS09080	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CVS35_RS09085	COG2807	transmembrane transport
CVS35_RS09090	COG0534	Mate efflux family protein
CVS35_RS09095	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CVS35_RS09155	COG0582	viral genome integration into host DNA
CVS35_RS09165	COG3083	sulfuric ester hydrolase activity
CVS35_RS09170	COG3082	Protein of unknown function (DUF1414)
CVS35_RS09175	COG3081	Nucleoid-associated protein
CVS35_RS09185	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CVS35_RS09190	COG1061	Type III restriction enzyme res subunit
CVS35_RS09200	COG1187	pseudouridine synthase activity
CVS35_RS09205	COG2814	Major facilitator Superfamily
CVS35_RS09215	COG4172	Belongs to the ABC transporter superfamily
CVS35_RS09220	COG4239	(ABC) transporter, permease
CVS35_RS09225	COG4174	ABC transporter (Permease)
CVS35_RS09230	COG4166	transmembrane transport
CVS35_RS09235	COG0791	NLP P60 protein
CVS35_RS09240	COG0671	phosphoesterase, PA-phosphatase related
CVS35_RS09245	COG0523	cobalamin synthesis protein
CVS35_RS09250	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CVS35_RS09270	COG1105	Belongs to the carbohydrate kinase PfkB family
CVS35_RS09275	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CVS35_RS09275	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
CVS35_RS09275	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CVS35_RS09280	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CVS35_RS09290	COG2855	membrane
CVS35_RS09295	COG0583	DNA-binding transcription factor activity
CVS35_RS09300	COG0833	amino acid
CVS35_RS09305	COG4771	TonB-dependent receptor
CVS35_RS09310	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CVS35_RS09315	COG1172	Belongs to the binding-protein-dependent transport system permease family
CVS35_RS09320	COG1129	ABC transporter
CVS35_RS09325	COG0371	Dehydrogenase
CVS35_RS09355	COG0583	DNA-binding transcription factor activity
CVS35_RS09360	COG0840	transmembrane signaling receptor activity
CVS35_RS09365	COG0302	gtp cyclohydrolase
CVS35_RS09370	COG2311	Membrane
CVS35_RS09375	COG2949	membrane
CVS35_RS09380	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CVS35_RS09400	COG1028	Short-chain dehydrogenase reductase Sdr
CVS35_RS09430	COG0259	pyridoxamine-phosphate oxidase activity
CVS35_RS09450	COG3321	synthase
CVS35_RS09450	COG0318	PFAM AMP-dependent synthetase and ligase
CVS35_RS09450	COG0300	oxidoreductase activity
CVS35_RS09450	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CVS35_RS09450	COG1028	Short-chain dehydrogenase reductase Sdr
CVS35_RS09460	COG2133	pyrroloquinoline quinone binding
CVS35_RS09465	COG0625	glutathione transferase activity
CVS35_RS09470	COG1464	Belongs to the NlpA lipoprotein family
CVS35_RS09475	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CVS35_RS09480	COG2011	ABC-type metal ion transport system permease component
CVS35_RS09485	COG1686	Belongs to the peptidase S11 family
CVS35_RS09490	COG1349	DNA-binding transcription factor activity
CVS35_RS09495	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CVS35_RS09500	COG2985	domain, Protein
CVS35_RS09500	COG0569	domain protein
CVS35_RS09525	COG0189	ligase activity
CVS35_RS09535	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CVS35_RS09540	COG3842	ATPase activity
CVS35_RS09545	COG1176	ABC-type spermidine putrescine transport system, permease component I
CVS35_RS09550	COG1177	transmembrane transport
CVS35_RS09560	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CVS35_RS09565	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CVS35_RS09570	COG4160	amino acid transport
CVS35_RS09575	COG4215	(ABC) transporter
CVS35_RS09580	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CVS35_RS09585	COG1126	abc transporter atp-binding protein
CVS35_RS09590	COG0393	Putative heavy-metal-binding
CVS35_RS09595	COG3023	N-Acetylmuramoyl-L-alanine amidase
CVS35_RS09600	COG0702	epimerase
CVS35_RS09605	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CVS35_RS09610	COG1151	hydroxylamine reductase activity
CVS35_RS09615	COG2431	L-lysine efflux transmembrane transporter activity
CVS35_RS09620	COG3593	DNA synthesis involved in DNA repair
CVS35_RS09625	COG1278	Cold shock
CVS35_RS09635	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CVS35_RS09640	COG0542	response to heat
CVS35_RS09645	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CVS35_RS09655	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CVS35_RS09660	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CVS35_RS09665	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CVS35_RS09670	COG4988	ABC transporter
CVS35_RS09675	COG0492	ferredoxin-NADP+ reductase activity
CVS35_RS09680	COG1522	sequence-specific DNA binding
CVS35_RS09685	COG3107	peptidoglycan biosynthetic process
CVS35_RS09685	COG1674	ftsk spoiiie
CVS35_RS09690	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CVS35_RS09695	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CVS35_RS09700	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CVS35_RS09705	COG0477	Major facilitator Superfamily
CVS35_RS09730	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CVS35_RS09735	COG1882	Formate acetyltransferase
CVS35_RS09740	COG2116	formate transmembrane transporter activity
CVS35_RS09745	COG1944	ATP diphosphatase activity
CVS35_RS09750	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CVS35_RS09755	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CVS35_RS09760	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CVS35_RS09765	COG0539	negative regulation of cytoplasmic translation
CVS35_RS09770	COG0776	regulation of translation
CVS35_RS09780	COG0140	phosphoribosyl-ATP diphosphatase activity
CVS35_RS09780	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CVS35_RS09785	COG0107	imidazoleglycerol-phosphate synthase activity
CVS35_RS09790	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CVS35_RS09795	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CVS35_RS09800	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CVS35_RS09800	COG0131	Imidazoleglycerol-phosphate dehydratase
CVS35_RS09805	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CVS35_RS09810	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CVS35_RS09815	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CVS35_RS09820	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CVS35_RS09825	COG0840	transmembrane signaling receptor activity
CVS35_RS09830	COG0840	transmembrane signaling receptor activity
CVS35_RS09835	COG4565	transcriptional regulatory protein
CVS35_RS09845	COG3493	citrate carrier protein
CVS35_RS09850	COG0179	Fumarylacetoacetate (FAA) hydrolase
CVS35_RS09855	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
CVS35_RS09860	COG3052	prosthetic group binding
CVS35_RS09880	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
CVS35_RS09885	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
CVS35_RS09895	COG0531	amino acid
CVS35_RS09900	COG2925	Exonuclease
CVS35_RS09905	COG4607	ABC-type enterochelin transport system periplasmic component
CVS35_RS09915	COG4605	iron ion homeostasis
CVS35_RS09920	COG4604	ABC transporter, ATP-binding protein
CVS35_RS09925	COG2926	Belongs to the UPF0265 family
CVS35_RS09930	COG0658	competence protein
CVS35_RS09930	COG2333	competence protein COMEC
CVS35_RS09935	COG1132	(ABC) transporter
CVS35_RS09940	COG1663	tetraacyldisaccharide 4'-kinase activity
CVS35_RS09945	COG2835	tetraacyldisaccharide 4'-kinase activity
CVS35_RS09950	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CVS35_RS09960	COG3173	Aminoglycoside phosphotransferase
CVS35_RS09965	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CVS35_RS09970	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CVS35_RS09975	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
CVS35_RS09980	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
CVS35_RS09985	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
CVS35_RS09990	COG2989	Protein conserved in bacteria
CVS35_RS09995	COG3108	Peptidase M15
CVS35_RS10000	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CVS35_RS10005	COG1448	Aminotransferase
CVS35_RS10015	COG0017	Asparaginyl-tRNA synthetase
CVS35_RS10020	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CVS35_RS10025	COG0308	aminopeptidase N
CVS35_RS10030	COG0167	dihydroorotate dehydrogenase activity
CVS35_RS10040	COG3217	Mosc domain protein beta barrel domain protein
CVS35_RS10040	COG0633	Ferredoxin
CVS35_RS10045	COG0116	Belongs to the methyltransferase superfamily
CVS35_RS10045	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CVS35_RS10050	COG0488	(ABC) transporter
CVS35_RS10055	COG2995	paraquat-inducible protein a
CVS35_RS10060	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CVS35_RS10060	COG3008	intermembrane lipid transfer
CVS35_RS10065	COG3009	Protein conserved in bacteria
CVS35_RS10075	COG3130	regulation of translation
CVS35_RS10080	COG0840	transmembrane signaling receptor activity
CVS35_RS10090	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CVS35_RS10095	COG3381	protein complex oligomerization
CVS35_RS10105	COG2999	glutathione oxidoreductase activity
CVS35_RS10110	COG0477	Major facilitator Superfamily
CVS35_RS10115	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CVS35_RS10120	COG3132	Protein of unknown function, DUF480
CVS35_RS10130	COG0728	peptidoglycan biosynthetic process
CVS35_RS10135	COG0018	arginyl-trna synthetase
CVS35_RS10140	COG3102	Protein conserved in bacteria
CVS35_RS10145	COG3142	Participates in the control of copper homeostasis
CVS35_RS10180	COG0500	methyltransferase
CVS35_RS10185	COG2226	methyltransferase
CVS35_RS10190	COG3788	relative of glutathione S-transferase, MAPEG superfamily
CVS35_RS10195	COG1801	Protein of unknown function DUF72
CVS35_RS10200	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
CVS35_RS10205	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CVS35_RS10210	COG0494	nUDIX hydrolase
CVS35_RS10215	COG0217	transcriptional regulatory protein
CVS35_RS10220	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CVS35_RS10225	COG0632	four-way junction helicase activity
CVS35_RS10230	COG2255	four-way junction helicase activity
CVS35_RS10235	COG4580	involved in the transport of maltose and maltodextrins
CVS35_RS10240	COG1447	Phosphotransferase system cellobiose-specific component IIA
CVS35_RS10245	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CVS35_RS10250	COG1609	Transcriptional regulator
CVS35_RS10255	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CVS35_RS10260	COG1121	(ABC) transporter
CVS35_RS10265	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
CVS35_RS10270	COG0739	heme binding
CVS35_RS10275	COG1560	Kdo2-lipid A biosynthetic process
CVS35_RS10280	COG0469	pyruvate kinase activity
CVS35_RS10285	COG1737	Transcriptional regulator
CVS35_RS10290	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CVS35_RS10295	COG0800	Aldolase
CVS35_RS10300	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
CVS35_RS10305	COG1770	oligopeptidase
CVS35_RS10315	COG1528	Iron-storage protein
CVS35_RS10325	COG1278	Cold shock
CVS35_RS10360	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
CVS35_RS10360	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CVS35_RS10365	COG3008	intermembrane lipid transfer
CVS35_RS10370	COG2995	paraquat-inducible protein a
CVS35_RS10375	COG1956	GAF domain-containing protein
CVS35_RS10380	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
CVS35_RS10395	COG1881	PFAM PEBP family protein
CVS35_RS10410	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CVS35_RS10420	COG1177	transmembrane transport
CVS35_RS10430	COG3842	ATPase activity
CVS35_RS10435	COG2195	Cleaves the N-terminal amino acid of tripeptides
CVS35_RS10440	COG2850	peptidyl-arginine hydroxylation
CVS35_RS10455	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CVS35_RS10460	COG2915	High frequency lysogenization protein hflD homolog
CVS35_RS10465	COG0482	sulfurtransferase activity
CVS35_RS10475	COG1187	pseudouridine synthase activity
CVS35_RS10480	COG0538	isocitrate dehydrogenase activity
CVS35_RS10485	COG0348	domain, Protein
CVS35_RS10505	COG3300	MHYT domain
CVS35_RS10505	COG5001	Diguanylate cyclase
CVS35_RS10510	COG3275	phosphorelay sensor kinase activity
CVS35_RS10515	COG3279	Response regulator of the LytR AlgR family
CVS35_RS10520	COG2223	nitrite transmembrane transporter activity
CVS35_RS10525	COG1653	transport
CVS35_RS10535	COG0501	Belongs to the peptidase M48B family
CVS35_RS10540	COG0823	Involved in the tonB-independent uptake of proteins
CVS35_RS10555	COG1113	amino acid transport
CVS35_RS10560	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CVS35_RS10565	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CVS35_RS10570	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CVS35_RS10575	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CVS35_RS10585	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CVS35_RS10590	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CVS35_RS10590	COG0072	phenylalanine-tRNA ligase activity
CVS35_RS10595	COG0776	regulation of translation
CVS35_RS10605	COG1132	(ABC) transporter
CVS35_RS10615	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CVS35_RS10620	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CVS35_RS10625	COG1823	symporter activity
CVS35_RS10630	COG1988	membrane-bound metal-dependent
CVS35_RS10635	COG2755	lipolytic protein G-D-S-L family
CVS35_RS10635	COG0657	acetylesterase activity
CVS35_RS10640	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CVS35_RS10645	COG1653	transport
CVS35_RS10650	COG3842	ATPase activity
CVS35_RS10655	COG0395	ABC-type sugar transport system, permease component
CVS35_RS10660	COG1175	transmembrane transport
CVS35_RS10670	COG1028	Short-chain dehydrogenase reductase Sdr
CVS35_RS10675	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
CVS35_RS10680	COG1917	Cupin 2, conserved barrel domain protein
CVS35_RS10685	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CVS35_RS10695	COG3001	Fructosamine kinase
CVS35_RS10700	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CVS35_RS10705	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CVS35_RS10710	COG1121	(ABC) transporter
CVS35_RS10715	COG0803	Belongs to the bacterial solute-binding protein 9 family
CVS35_RS10730	COG2226	methyltransferase
CVS35_RS10735	COG1971	Probably functions as a manganese efflux pump
CVS35_RS10740	COG4811	Protein of unknown function (DUF986)
CVS35_RS10745	COG3716	PTS system mannose fructose sorbose family IID component
CVS35_RS10750	COG3715	PTS system
CVS35_RS10755	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CVS35_RS10755	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CVS35_RS10760	COG1253	flavin adenine dinucleotide binding
CVS35_RS10765	COG1335	isochorismatase
CVS35_RS10770	COG1250	3-hydroxyacyl-CoA dehydrogenase
CVS35_RS10770	COG0824	Thioesterase
CVS35_RS10775	COG0583	DNA-binding transcription factor activity
CVS35_RS10780	COG1760	l-serine dehydratase
CVS35_RS10785	COG0494	nUDIX hydrolase
CVS35_RS10795	COG3140	Belongs to the UPF0181 family
CVS35_RS10800	COG0251	oxidation-reduction process
CVS35_RS10805	COG1199	ATP-dependent helicase activity
CVS35_RS10810	COG1214	PFAM Peptidase M22, glycoprotease
CVS35_RS10815	COG3065	identical protein binding
CVS35_RS10820	COG0318	PFAM AMP-dependent synthetase and ligase
CVS35_RS10825	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
CVS35_RS10830	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CVS35_RS10835	COG2894	cell division
CVS35_RS10840	COG0850	regulation of cytokinetic process
CVS35_RS10845	COG3100	YcgL domain-containing protein
CVS35_RS10850	COG0179	Fumarylacetoacetate (FAA) hydrolase
CVS35_RS10855	COG2983	Belongs to the UPF0260 family
CVS35_RS10870	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CVS35_RS10875	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CVS35_RS10880	COG2186	Transcriptional regulator
CVS35_RS10885	COG2719	SpoVR family
CVS35_RS10890	COG3684	Belongs to the aldolase LacD family
CVS35_RS10900	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CVS35_RS10920	COG0205	6-phosphofructokinase activity
CVS35_RS10925	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CVS35_RS10940	COG2718	Belongs to the UPF0229 family
CVS35_RS10945	COG2766	serine protein kinase
CVS35_RS10950	COG3713	MltA-interacting MipA family protein
CVS35_RS10955	COG0656	L-ascorbic acid biosynthetic process
CVS35_RS10965	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CVS35_RS10970	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CVS35_RS10975	COG3139	Protein of unknown function (DUF1315)
CVS35_RS10980	COG1335	isochorismatase
CVS35_RS10985	COG0252	asparaginase activity
CVS35_RS10990	COG0616	signal peptide processing
CVS35_RS10995	COG0778	Nitroreductase
CVS35_RS11000	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CVS35_RS11010	COG0708	Exodeoxyribonuclease III
CVS35_RS11015	COG2860	membrane
CVS35_RS11030	COG0788	formyltetrahydrofolate deformylase activity
CVS35_RS11035	COG3012	SEC-C Motif Domain Protein
CVS35_RS11040	COG1752	Esterase of the alpha-beta hydrolase superfamily
CVS35_RS11045	COG0745	RESPONSE REGULATOR receiver
CVS35_RS11050	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CVS35_RS11060	COG1435	thymidine kinase activity
CVS35_RS11065	COG1012	belongs to the aldehyde dehydrogenase family
CVS35_RS11065	COG1454	alcohol dehydrogenase
CVS35_RS11080	COG0601	transmembrane transport
CVS35_RS11085	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CVS35_RS11090	COG0444	Belongs to the ABC transporter superfamily
CVS35_RS11100	COG3099	Belongs to the UPF0263 family
CVS35_RS11105	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CVS35_RS11115	COG2350	Protein conserved in bacteria
CVS35_RS11125	COG1607	acyl-coa hydrolase
CVS35_RS11130	COG2917	probably involved in intracellular septation
CVS35_RS11145	COG3047	cAMP biosynthetic process
CVS35_RS11150	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CVS35_RS11155	COG0159	tryptophan synthase activity
CVS35_RS11160	COG0133	tryptophan synthase activity
CVS35_RS11165	COG0134	indole-3-glycerol-phosphate synthase activity
CVS35_RS11165	COG0135	phosphoribosylanthranilate isomerase activity
CVS35_RS11170	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CVS35_RS11175	COG0512	Glutamine amidotransferase of anthranilate synthase
CVS35_RS11190	COG1215	transferase activity, transferring glycosyl groups
CVS35_RS11195	COG0613	PHP domain protein
CVS35_RS11200	COG0009	L-threonylcarbamoyladenylate synthase
CVS35_RS11205	COG1187	pseudouridine synthase activity
CVS35_RS11215	COG1028	Short-chain dehydrogenase reductase Sdr
CVS35_RS11220	COG0616	signal peptide processing
CVS35_RS11245	COG3104	oligopeptide transport
CVS35_RS11250	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CVS35_RS11260	COG4659	FMN binding
CVS35_RS11265	COG4658	electron transport chain
CVS35_RS11270	COG4656	Part of a membrane complex involved in electron transport
CVS35_RS11275	COG2878	Part of a membrane complex involved in electron transport
CVS35_RS11280	COG4657	Part of a membrane complex involved in electron transport
CVS35_RS11285	COG2160	L-arabinose isomerase activity
CVS35_RS11290	COG1069	ribulokinase activity
CVS35_RS11295	COG1879	ABC-type sugar transport system periplasmic component
CVS35_RS11300	COG1129	ABC transporter
CVS35_RS11305	COG1172	Belongs to the binding-protein-dependent transport system permease family
CVS35_RS11315	COG0673	inositol 2-dehydrogenase activity
CVS35_RS11320	COG0385	Bile acid
CVS35_RS11330	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CVS35_RS11340	COG5339	Protein conserved in bacteria
CVS35_RS11345	COG1482	cell wall glycoprotein biosynthetic process
CVS35_RS11350	COG0114	fumarate hydratase activity
CVS35_RS11360	COG2814	Major facilitator Superfamily
CVS35_RS11365	COG0583	DNA-binding transcription factor activity
CVS35_RS11370	COG1940	carbohydrate kinase activity
CVS35_RS11375	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CVS35_RS11380	COG0477	Major facilitator Superfamily
CVS35_RS11400	COG4221	oxidoreductase activity
CVS35_RS11405	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CVS35_RS11410	COG1215	transferase activity, transferring glycosyl groups
CVS35_RS11425	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CVS35_RS11430	COG1942	4-Oxalocrotonate Tautomerase
CVS35_RS11435	COG0076	glutamate decarboxylase activity
CVS35_RS11440	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CVS35_RS11455	COG1649	PFAM Uncharacterised BCR, COG1649
CVS35_RS11460	COG4628	conserved protein (DUF2132)
CVS35_RS11495	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CVS35_RS11505	COG1073	alpha beta
CVS35_RS11510	COG1902	pentaerythritol trinitrate reductase activity
CVS35_RS11570	COG0456	acetyltransferase
CVS35_RS11575	COG0738	Major facilitator superfamily
CVS35_RS11585	COG3783	Cytochrome b(562)
CVS35_RS11590	COG1764	response to oxidative stress
CVS35_RS11595	COG4305	rare lipoprotein A
CVS35_RS11620	COG1028	Short-chain dehydrogenase reductase Sdr
CVS35_RS11635	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CVS35_RS11650	COG0673	inositol 2-dehydrogenase activity
CVS35_RS11655	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CVS35_RS11660	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CVS35_RS11670	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
CVS35_RS11675	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CVS35_RS11715	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CVS35_RS11720	COG2912	Transglutaminase-like superfamily
CVS35_RS11730	COG2890	protein-(glutamine-N5) methyltransferase activity
CVS35_RS11735	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CVS35_RS11740	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CVS35_RS11745	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
CVS35_RS11750	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CVS35_RS11755	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CVS35_RS11765	COG0193	aminoacyl-tRNA hydrolase activity
CVS35_RS11770	COG0012	GTP binding
CVS35_RS11855	COG0346	lactoylglutathione lyase activity
CVS35_RS11860	COG0483	inositol monophosphate 1-phosphatase activity
CVS35_RS11865	COG2723	6-phospho-beta-galactosidase activity
CVS35_RS11870	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CVS35_RS11870	COG1263	PTS System
CVS35_RS11875	COG1609	Transcriptional regulator
CVS35_RS11880	COG2234	aminopeptidase activity
CVS35_RS11895	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CVS35_RS11900	COG1473	amidohydrolase
CVS35_RS11910	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CVS35_RS11920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CVS35_RS11930	COG0765	amino acid transport
CVS35_RS11935	COG1126	abc transporter atp-binding protein
CVS35_RS11940	COG2226	methyltransferase
CVS35_RS11950	COG2314	TM2 domain
CVS35_RS11965	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CVS35_RS11980	COG0683	leucine binding
CVS35_RS11985	COG1802	Transcriptional regulator
CVS35_RS12050	COG2831	hemolysin activation secretion protein
CVS35_RS12055	COG1802	Transcriptional regulator
CVS35_RS12110	COG3501	Rhs element vgr protein
CVS35_RS12155	COG4669	(LipO)protein
CVS35_RS12170	COG2200	EAL domain
CVS35_RS12180	COG2197	response regulator
CVS35_RS12185	COG3850	Histidine kinase
CVS35_RS12210	COG1157	protein secretion by the type III secretion system
CVS35_RS12235	COG4794	Type iii secretion
CVS35_RS12245	COG4792	protein secretion
CVS35_RS12250	COG0583	DNA-binding transcription factor activity
CVS35_RS12275	COG2814	Major facilitator Superfamily
CVS35_RS12295	COG1464	Belongs to the NlpA lipoprotein family
CVS35_RS12300	COG4948	Mandelate Racemase Muconate Lactonizing
CVS35_RS12305	COG2011	ABC-type metal ion transport system permease component
CVS35_RS12310	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CVS35_RS12315	COG0671	phosphoesterase, PA-phosphatase related
CVS35_RS12325	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CVS35_RS12335	COG1028	Short-chain dehydrogenase reductase Sdr
CVS35_RS12350	COG1176	ABC-type spermidine putrescine transport system, permease component I
CVS35_RS12360	COG1012	belongs to the aldehyde dehydrogenase family
CVS35_RS12365	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CVS35_RS12375	COG3842	ATPase activity
CVS35_RS12380	COG1280	lysine exporter protein (LysE YggA)
CVS35_RS12410	COG2261	transglycosylase associated protein
CVS35_RS12450	COG1846	Transcriptional regulator
CVS35_RS12455	COG0697	spore germination
CVS35_RS12460	COG2181	nitrate reductase activity
CVS35_RS12465	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
CVS35_RS12470	COG1140	nitrate reductase beta subunit
CVS35_RS12475	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
CVS35_RS12485	COG2223	nitrite transmembrane transporter activity
CVS35_RS12490	COG3850	Histidine kinase
CVS35_RS12495	COG2197	response regulator
CVS35_RS12510	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
CVS35_RS12520	COG0387	Pfam Sodium calcium exchanger
CVS35_RS12525	COG0659	secondary active sulfate transmembrane transporter activity
CVS35_RS12555	COG0745	RESPONSE REGULATOR receiver
CVS35_RS12560	COG2205	protein histidine kinase activity
CVS35_RS12575	COG3591	Belongs to the peptidase S1B family
CVS35_RS12580	COG3300	MHYT domain
CVS35_RS12580	COG5001	Diguanylate cyclase
CVS35_RS12590	COG1643	Atp-dependent helicase
CVS35_RS12595	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CVS35_RS12605	COG2911	Protein conserved in bacteria
CVS35_RS12610	COG0840	transmembrane signaling receptor activity
CVS35_RS12615	COG0840	transmembrane signaling receptor activity
CVS35_RS12620	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CVS35_RS12650	COG0037	tRNA processing
CVS35_RS12655	COG0598	Magnesium transport protein CorA
CVS35_RS12660	COG4166	transmembrane transport
CVS35_RS12665	COG2866	Carboxypeptidase
CVS35_RS12670	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CVS35_RS12685	COG3768	UPF0283 membrane protein
CVS35_RS12690	COG3106	COG3106 Predicted ATPase
CVS35_RS12695	COG1983	PspC domain protein
CVS35_RS12705	COG1842	Phage shock protein A
CVS35_RS12710	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CVS35_RS12715	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
CVS35_RS12725	COG1028	Short-chain dehydrogenase reductase Sdr
CVS35_RS12735	COG4166	transmembrane transport
CVS35_RS12745	COG4171	peptide transport system, permease
CVS35_RS12775	COG1053	succinate dehydrogenase
CVS35_RS12785	COG2271	Major facilitator Superfamily
CVS35_RS12790	COG1609	Transcriptional regulator
CVS35_RS12795	COG0583	DNA-binding transcription factor activity
CVS35_RS12800	COG0243	molybdopterin cofactor binding
CVS35_RS12810	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
CVS35_RS12815	COG4989	oxidoreductase activity
CVS35_RS12820	COG1966	Carbon starvation protein
CVS35_RS12825	COG0235	Class ii aldolase
CVS35_RS12835	COG0023	Translation Initiation Factor
CVS35_RS12840	COG0284	orotidine-5'-phosphate decarboxylase activity
CVS35_RS12845	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
CVS35_RS12850	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
CVS35_RS12860	COG1082	Xylose isomerase domain protein TIM barrel
CVS35_RS12865	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CVS35_RS12870	COG3958	Transketolase
CVS35_RS12875	COG3959	Transketolase, thiamine diphosphate binding domain
CVS35_RS12880	COG1172	Belongs to the binding-protein-dependent transport system permease family
CVS35_RS12885	COG1129	ABC transporter
CVS35_RS12895	COG1879	ABC-type sugar transport system periplasmic component
CVS35_RS12900	COG0671	phosphoesterase, PA-phosphatase related
CVS35_RS12905	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CVS35_RS12925	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CVS35_RS12935	COG1301	dicarboxylic acid transport
CVS35_RS12940	COG0625	glutathione transferase activity
CVS35_RS12945	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
CVS35_RS12950	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CVS35_RS12955	COG0259	pyridoxamine-phosphate oxidase activity
CVS35_RS12960	COG3895	Periplasmic Protein
CVS35_RS12965	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CVS35_RS12975	COG1846	Transcriptional regulator
CVS35_RS12980	COG3313	Fe-S protein
CVS35_RS12985	COG0346	lactoylglutathione lyase activity
CVS35_RS12990	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CVS35_RS12995	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CVS35_RS13000	COG0791	NLP P60 protein
CVS35_RS13010	COG1609	Transcriptional regulator
CVS35_RS13015	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CVS35_RS13020	COG0307	riboflavin synthase, alpha
CVS35_RS13025	COG0534	Mate efflux family protein
CVS35_RS13035	COG1620	l-lactate permease
CVS35_RS13040	COG0247	lactate metabolic process
CVS35_RS13045	COG1139	Iron-sulfur cluster binding protein
CVS35_RS13050	COG1556	Lactate utilization protein
CVS35_RS13070	COG1116	anion transmembrane transporter activity
CVS35_RS13070	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CVS35_RS13095	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
CVS35_RS13100	COG1408	metallophosphoesterase
CVS35_RS13110	COG0561	phosphatase activity
CVS35_RS13120	COG4221	oxidoreductase activity
CVS35_RS13130	COG0477	Major facilitator Superfamily
CVS35_RS13140	COG2197	response regulator
CVS35_RS13145	COG3850	Histidine kinase
CVS35_RS13150	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
CVS35_RS13150	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CVS35_RS13155	COG3062	negative regulation of establishment of protein localization
CVS35_RS13160	COG0243	molybdopterin cofactor binding
CVS35_RS13165	COG0437	4 iron, 4 sulfur cluster binding
CVS35_RS13170	COG0348	domain, Protein
CVS35_RS13175	COG3043	anaerobic respiration
CVS35_RS13180	COG3005	denitrification pathway
CVS35_RS13190	COG3088	subunit of a heme lyase
CVS35_RS13190	COG4235	cytochrome complex assembly
CVS35_RS13195	COG3088	subunit of a heme lyase
CVS35_RS13195	COG4235	cytochrome complex assembly
CVS35_RS13200	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CVS35_RS13205	COG1138	Cytochrome C-type biogenesis protein
CVS35_RS13210	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
CVS35_RS13215	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CVS35_RS13220	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CVS35_RS13225	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CVS35_RS13230	COG4133	protoheme IX ABC transporter activity
CVS35_RS13235	COG4235	cytochrome complex assembly
CVS35_RS13240	COG3088	subunit of a heme lyase
CVS35_RS13245	COG1138	Cytochrome C-type biogenesis protein
CVS35_RS13250	COG3301	Polysulphide reductase, NrfD
CVS35_RS13255	COG0437	4 iron, 4 sulfur cluster binding
CVS35_RS13260	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
CVS35_RS13265	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
CVS35_RS13275	COG2382	esterase
CVS35_RS13310	COG4238	major outer membrane lipoprotein
CVS35_RS13315	COG1376	ErfK ybiS ycfS ynhG family protein
CVS35_RS13315	COG1388	LysM domain
CVS35_RS13320	COG2166	iron-sulfur cluster assembly
CVS35_RS13325	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CVS35_RS13330	COG0719	Fe-S assembly protein
CVS35_RS13335	COG0396	ATPase activity
CVS35_RS13340	COG0719	Fe-S assembly protein
CVS35_RS13345	COG0316	Belongs to the HesB IscA family
CVS35_RS13355	COG2050	protein possibly involved in aromatic compounds catabolism
CVS35_RS13360	COG0247	lactate metabolic process
CVS35_RS13360	COG0277	FAD linked oxidase domain protein
CVS35_RS13365	COG0628	permease
CVS35_RS13375	COG1477	protein flavinylation
CVS35_RS13380	COG0574	Belongs to the PEP-utilizing enzyme family
CVS35_RS13380	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CVS35_RS13385	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CVS35_RS13390	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CVS35_RS13395	COG0366	Alpha amylase catalytic
CVS35_RS13400	COG2188	Transcriptional regulator
CVS35_RS13415	COG3720	iron ion transport
CVS35_RS13420	COG4558	Periplasmic binding protein
CVS35_RS13425	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CVS35_RS13430	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CVS35_RS13435	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CVS35_RS13445	COG2610	gluconate transmembrane transporter activity
CVS35_RS13450	COG3265	gluconokinase activity
CVS35_RS13455	COG1609	Transcriptional regulator
CVS35_RS13460	COG0129	dihydroxy-acid dehydratase activity
CVS35_RS13465	COG0791	NLP P60 protein
CVS35_RS13470	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
CVS35_RS13475	COG0386	Belongs to the glutathione peroxidase family
CVS35_RS13480	COG4139	cobalamin transport
CVS35_RS13485	COG2226	methyltransferase
CVS35_RS13510	COG1940	carbohydrate kinase activity
CVS35_RS13515	COG4591	ABC-type transport system involved in lipoprotein release permease component
CVS35_RS13520	COG1136	(ABC) transporter
CVS35_RS13525	COG4591	ABC-type transport system involved in lipoprotein release permease component
CVS35_RS13530	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CVS35_RS13535	COG0443	Heat shock 70 kDa protein
CVS35_RS13540	COG1309	transcriptional regulator
CVS35_RS13555	COG3134	Outer membrane lipoprotein
CVS35_RS13560	COG1252	NADH dehydrogenase
CVS35_RS13565	COG3150	esterase
CVS35_RS13570	COG1472	Belongs to the glycosyl hydrolase 3 family
CVS35_RS13580	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
CVS35_RS13590	COG0537	adenosine 5'-monophosphoramidase activity
CVS35_RS13595	COG0477	Major facilitator Superfamily
CVS35_RS13605	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CVS35_RS13605	COG1263	PTS System
CVS35_RS13610	COG0084	hydrolase, TatD family'
CVS35_RS13615	COG0470	DNA polymerase III
CVS35_RS13620	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CVS35_RS13625	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CVS35_RS13630	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CVS35_RS13635	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CVS35_RS13640	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CVS35_RS13650	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CVS35_RS13655	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CVS35_RS13660	COG0416	fatty acid biosynthetic process
CVS35_RS13665	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CVS35_RS13670	COG1399	metal-binding, possibly nucleic acid-binding protein
CVS35_RS13675	COG0424	maF-like protein
CVS35_RS13685	COG1530	ribonuclease E activity
CVS35_RS13695	COG0418	dihydroorotase activity
CVS35_RS13715	COG3038	cytochrome b561
CVS35_RS13720	COG2353	YceI-like domain
CVS35_RS13725	COG1054	Belongs to the UPF0176 family
CVS35_RS13730	COG1902	pentaerythritol trinitrate reductase activity
CVS35_RS13735	COG1560	Kdo2-lipid A biosynthetic process
CVS35_RS13740	COG2943	transferase activity, transferring hexosyl groups
CVS35_RS13745	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
CVS35_RS13780	COG1683	Conserved Protein
CVS35_RS13785	COG0589	response to stress
CVS35_RS13815	COG0670	Belongs to the BI1 family
CVS35_RS13820	COG2920	part of a sulfur-relay system
CVS35_RS13825	COG1254	Belongs to the acylphosphatase family
CVS35_RS13830	COG3785	DNA binding
CVS35_RS13835	COG1832	CoA-binding protein
CVS35_RS13840	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
CVS35_RS13845	COG1803	Methylglyoxal synthase
CVS35_RS13850	COG0210	DNA helicase
CVS35_RS13855	COG3304	Inner membrane component domain
CVS35_RS13860	COG1289	transmembrane transporter activity
CVS35_RS13865	COG3070	regulator of competence-specific genes
CVS35_RS13870	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
CVS35_RS13885	COG1067	ATP-dependent peptidase activity
CVS35_RS13890	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CVS35_RS13895	COG2979	Protein of unknown function (DUF533)
CVS35_RS13900	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
CVS35_RS13905	COG1012	belongs to the aldehyde dehydrogenase family
CVS35_RS13910	COG1309	transcriptional regulator
CVS35_RS13915	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CVS35_RS13930	COG1702	phosphate starvation-inducible protein PhoH
CVS35_RS13940	COG1191	sigma factor activity
CVS35_RS13975	COG0500	methyltransferase
CVS35_RS14000	COG1677	Flagellar hook-basal body complex protein FliE
CVS35_RS14015	COG1317	bacterial-type flagellum organization
CVS35_RS14035	COG1580	Controls the rotational direction of flagella during chemotaxis
CVS35_RS14085	COG1706	bacterial-type flagellum-dependent cell motility
CVS35_RS14090	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
CVS35_RS14100	COG4787	bacterial-type flagellum-dependent cell motility
CVS35_RS14105	COG1749	Flagellar hook protein flgE
CVS35_RS14110	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CVS35_RS14115	COG1558	bacterial-type flagellum-dependent cell motility
CVS35_RS14120	COG1815	bacterial-type flagellum-dependent cell motility
CVS35_RS14130	COG2747	anti-sigma28 factor FlgM
CVS35_RS14145	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CVS35_RS14150	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CVS35_RS14160	COG0745	RESPONSE REGULATOR receiver
CVS35_RS14165	COG2201	protein-glutamate methylesterase activity
CVS35_RS14170	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CVS35_RS14175	COG0840	transmembrane signaling receptor activity
CVS35_RS14180	COG0835	chemotaxis
CVS35_RS14185	COG2198	Histidine kinase
CVS35_RS14185	COG0643	Histidine kinase
CVS35_RS14210	COG0697	spore germination
CVS35_RS14215	COG0840	transmembrane signaling receptor activity
CVS35_RS14235	COG3228	Belongs to the MtfA family
CVS35_RS14245	COG0583	DNA-binding transcription factor activity
CVS35_RS14250	COG1902	pentaerythritol trinitrate reductase activity
CVS35_RS14260	COG1028	Short-chain dehydrogenase reductase Sdr
CVS35_RS14270	COG2814	Major facilitator Superfamily
CVS35_RS14300	COG0300	oxidoreductase activity
CVS35_RS14305	COG1733	regulation of RNA biosynthetic process
CVS35_RS14310	COG2085	NADP oxidoreductase coenzyme F420-dependent
CVS35_RS14325	COG3604	Transcriptional regulator
CVS35_RS14330	COG2205	protein histidine kinase activity
CVS35_RS14385	COG1309	transcriptional regulator
CVS35_RS14390	COG2814	Major facilitator Superfamily
CVS35_RS14415	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
CVS35_RS14425	COG0659	secondary active sulfate transmembrane transporter activity
CVS35_RS14435	COG0444	Belongs to the ABC transporter superfamily
CVS35_RS14445	COG0601	transmembrane transport
CVS35_RS14450	COG0747	negative chemotaxis
CVS35_RS14465	COG4948	Mandelate Racemase Muconate Lactonizing
CVS35_RS14480	COG3713	MltA-interacting MipA family protein
CVS35_RS14485	COG0745	RESPONSE REGULATOR receiver
CVS35_RS14490	COG5002	protein histidine kinase activity
CVS35_RS14490	COG5000	phosphorelay sensor kinase activity
CVS35_RS14505	COG0765	amino acid transport
CVS35_RS14510	COG0765	amino acid transport
CVS35_RS14515	COG1126	abc transporter atp-binding protein
CVS35_RS14535	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
CVS35_RS14535	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
CVS35_RS14560	COG1902	pentaerythritol trinitrate reductase activity
CVS35_RS14565	COG0640	Transcriptional regulator
CVS35_RS14570	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
CVS35_RS14575	COG4807	Protein conserved in bacteria
CVS35_RS14585	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CVS35_RS14585	COG1648	precorrin-2 dehydrogenase activity
CVS35_RS14590	COG0243	molybdopterin cofactor binding
CVS35_RS14595	COG2146	nitrite reductase [NAD(P)H] activity
CVS35_RS14595	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CVS35_RS14600	COG1116	anion transmembrane transporter activity
CVS35_RS14610	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CVS35_RS14620	COG3707	response regulator
CVS35_RS14635	COG1271	oxidase subunit
CVS35_RS14640	COG1294	oxidase, subunit
CVS35_RS14645	COG4890	Cyd operon protein YbgT
CVS35_RS14650	COG2149	membrane
CVS35_RS14660	COG3058	Necessary for formate dehydrogenase activity
CVS35_RS14665	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CVS35_RS14670	COG0519	Catalyzes the synthesis of GMP from XMP
CVS35_RS14670	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CVS35_RS14695	COG0488	(ABC) transporter
CVS35_RS14705	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CVS35_RS14715	COG3547	Transposase (IS116 IS110 IS902 family)
CVS35_RS14740	COG1263	PTS System
CVS35_RS14740	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CVS35_RS14745	COG0366	Alpha amylase catalytic
CVS35_RS14750	COG4575	ribosome binding
CVS35_RS14755	COG1007	ATP synthesis coupled electron transport
CVS35_RS14760	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CVS35_RS14765	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CVS35_RS14770	COG0713	ATP synthesis coupled electron transport
CVS35_RS14775	COG0839	Belongs to the complex I subunit 6 family
CVS35_RS14780	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CVS35_RS14785	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CVS35_RS14795	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
CVS35_RS14800	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
CVS35_RS14805	COG0649	NAD binding
CVS35_RS14805	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CVS35_RS14810	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CVS35_RS14815	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CVS35_RS14820	COG0583	DNA-binding transcription factor activity
CVS35_RS14825	COG0436	Aminotransferase
CVS35_RS14830	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
CVS35_RS14835	COG0490	domain, Protein
CVS35_RS14835	COG0471	metal ion transport
CVS35_RS14840	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CVS35_RS14845	COG3013	Belongs to the UPF0304 family
CVS35_RS14850	COG3092	negative regulation of chromosome organization
CVS35_RS14855	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CVS35_RS14860	COG0857	belongs to the CobB CobQ family
CVS35_RS14860	COG0280	phosphate acetyltransferase
CVS35_RS14865	COG3739	integral membrane protein
CVS35_RS14870	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CVS35_RS14875	COG0622	Phosphoesterase
CVS35_RS14880	COG0625	glutathione transferase activity
CVS35_RS14885	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CVS35_RS14895	COG1090	epimerase
CVS35_RS14900	COG4598	ABC transporter
CVS35_RS14905	COG4160	amino acid transport
CVS35_RS14910	COG4215	(ABC) transporter
CVS35_RS14920	COG0163	prenyltransferase activity
CVS35_RS14925	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CVS35_RS14930	COG1286	toxin biosynthetic process
CVS35_RS14935	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
CVS35_RS14940	COG0285	dihydrofolate synthase activity
CVS35_RS14945	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CVS35_RS14955	COG0586	Pfam SNARE associated Golgi protein
CVS35_RS14960	COG0101	tRNA pseudouridine synthase activity
CVS35_RS14965	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CVS35_RS14970	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CVS35_RS14975	COG0697	spore germination
CVS35_RS14985	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CVS35_RS14990	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
CVS35_RS14990	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CVS35_RS15000	COG3101	peptidyl-lysine hydroxylation
CVS35_RS15005	COG0730	response to heat
CVS35_RS15010	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
CVS35_RS15015	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CVS35_RS15020	COG2890	protein-(glutamine-N5) methyltransferase activity
CVS35_RS15025	COG2840	Smr protein MutS2
CVS35_RS15030	COG2062	phosphohistidine phosphatase, SixA
CVS35_RS15055	COG3188	usher protein
CVS35_RS15065	COG1250	3-hydroxyacyl-CoA dehydrogenase
CVS35_RS15065	COG1024	Enoyl-CoA hydratase
CVS35_RS15070	COG0183	Belongs to the thiolase family
CVS35_RS15075	COG3691	Protein conserved in bacteria
CVS35_RS15085	COG0579	oxidoreductase
CVS35_RS15100	COG2116	formate transmembrane transporter activity
CVS35_RS15110	COG0582	viral genome integration into host DNA
CVS35_RS15210	COG0513	Belongs to the DEAD box helicase family
CVS35_RS15220	COG1120	ATPase activity
CVS35_RS15225	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CVS35_RS15230	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CVS35_RS15235	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CVS35_RS15315	COG3866	Pectate lyase
CVS35_RS15320	COG3266	domain, Protein
CVS35_RS15330	COG0436	Aminotransferase
CVS35_RS15335	COG4948	Mandelate Racemase Muconate Lactonizing
CVS35_RS15345	COG3264	Mechanosensitive ion channel
CVS35_RS15345	COG1511	domain protein
CVS35_RS15400	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CVS35_RS15405	COG1696	Membrane protein involved in D-alanine export
CVS35_RS15450	COG3423	Transcriptional regulator
CVS35_RS15460	COG2842	Transposition protein
CVS35_RS15530	COG0741	lytic transglycosylase activity
CVS35_RS15565	COG4383	Mu-like prophage protein gp29
CVS35_RS15590	COG4397	Mu-like prophage major head subunit gpT
CVS35_RS15670	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CVS35_RS15675	COG1447	Phosphotransferase system cellobiose-specific component IIA
CVS35_RS15690	COG3842	ATPase activity
CVS35_RS15695	COG2076	Multidrug Resistance protein
CVS35_RS15700	COG2076	Multidrug Resistance protein
CVS35_RS15705	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CVS35_RS15710	COG0726	polysaccharide deacetylase
CVS35_RS15715	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CVS35_RS15715	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CVS35_RS15720	COG0463	Glycosyl transferase, family 2
CVS35_RS15725	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CVS35_RS15730	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CVS35_RS15735	COG5001	Diguanylate cyclase
CVS35_RS15735	COG2203	Gaf domain
CVS35_RS15735	COG4251	negative regulation of phosphorylation
CVS35_RS15735	COG3706	GGDEF domain
CVS35_RS15740	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CVS35_RS15745	COG2501	S4 domain
CVS35_RS15750	COG0215	cysteine-tRNA ligase activity
CVS35_RS15760	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CVS35_RS15765	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CVS35_RS15770	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CVS35_RS15775	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CVS35_RS15780	COG0814	amino acid
CVS35_RS15785	COG1760	l-serine dehydratase
CVS35_RS15795	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CVS35_RS15800	COG0581	inorganic phosphate transmembrane transporter activity
CVS35_RS15805	COG0573	inorganic phosphate transmembrane transporter activity
CVS35_RS15810	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CVS35_RS15830	COG1764	response to oxidative stress
CVS35_RS15835	COG1846	Transcriptional regulator
CVS35_RS15840	COG2239	Acts as a magnesium transporter
CVS35_RS15850	COG1085	galactose-1-phosphate uridylyltransferase
CVS35_RS15855	COG1609	Transcriptional regulator
CVS35_RS15860	COG4580	involved in the transport of maltose and maltodextrins
CVS35_RS15865	COG3842	ATPase activity
CVS35_RS15870	COG2182	Extracellular solute-binding protein
CVS35_RS15875	COG1175	transmembrane transport
CVS35_RS15880	COG3833	ABC-type maltose transport systems, permease component
CVS35_RS15885	COG3867	Arabinogalactan endo-beta-1,4-galactanase
CVS35_RS15890	COG1874	Beta-galactosidase
CVS35_RS15900	COG0277	FAD linked oxidase domain protein
CVS35_RS15910	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CVS35_RS15915	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CVS35_RS15920	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CVS35_RS15925	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CVS35_RS15935	COG0477	Major facilitator Superfamily
CVS35_RS15940	COG2205	protein histidine kinase activity
CVS35_RS15945	COG0745	RESPONSE REGULATOR receiver
CVS35_RS15960	COG0435	Glutathione S-transferase
CVS35_RS15965	COG0826	peptidase U32
CVS35_RS15970	COG1597	lipid kinase activity
CVS35_RS15975	COG3223	Belongs to the PsiE family
CVS35_RS15985	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
CVS35_RS15995	COG1064	alcohol dehydrogenase
CVS35_RS16000	COG3706	GGDEF domain
CVS35_RS16035	COG3423	Transcriptional regulator
CVS35_RS16045	COG0519	Catalyzes the synthesis of GMP from XMP
CVS35_RS16045	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CVS35_RS16055	COG1570	exodeoxyribonuclease VII activity
CVS35_RS16070	COG0662	Cupin 2, conserved barrel domain protein
CVS35_RS16070	COG2207	Transcriptional regulator
CVS35_RS16075	COG1028	Short-chain dehydrogenase reductase Sdr
CVS35_RS16085	COG1160	GTP binding
CVS35_RS16090	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CVS35_RS16095	COG2976	Protein conserved in bacteria
CVS35_RS16100	COG0124	histidyl-tRNA synthetase
CVS35_RS16105	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CVS35_RS16110	COG1426	Protein conserved in bacteria
CVS35_RS16120	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CVS35_RS16125	COG0105	UTP biosynthetic process
CVS35_RS16130	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CVS35_RS16130	COG2190	(PTS) system
CVS35_RS16130	COG1263	PTS System
CVS35_RS16135	COG1486	melibiose metabolic process
CVS35_RS16140	COG2897	thiosulfate sulfurtransferase activity
CVS35_RS16145	COG1737	Transcriptional regulator
CVS35_RS16155	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CVS35_RS16160	COG2975	iron-sulfur cluster assembly
CVS35_RS16165	COG0633	Ferredoxin
CVS35_RS16170	COG0443	Heat shock 70 kDa protein
CVS35_RS16175	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CVS35_RS16180	COG0316	Belongs to the HesB IscA family
CVS35_RS16185	COG0822	iron-sulfur transferase activity
CVS35_RS16190	COG1104	cysteine desulfurase activity
CVS35_RS16195	COG1959	2 iron, 2 sulfur cluster binding
CVS35_RS16200	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
CVS35_RS16205	COG0483	inositol monophosphate 1-phosphatase activity
CVS35_RS16215	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CVS35_RS16240	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
CVS35_RS16245	COG3683	transport system, periplasmic component
CVS35_RS16250	COG2814	Major facilitator Superfamily
CVS35_RS16260	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CVS35_RS16265	COG1017	nitric oxide dioxygenase activity
CVS35_RS16265	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CVS35_RS16275	COG4677	pectinesterase activity
CVS35_RS16280	COG0347	Belongs to the P(II) protein family
CVS35_RS16285	COG2204	response regulator
CVS35_RS16290	COG3170	Tfp pilus assembly protein FimV
CVS35_RS16295	COG2205	protein histidine kinase activity
CVS35_RS16300	COG0047	phosphoribosylformylglycinamidine synthase activity
CVS35_RS16300	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CVS35_RS16305	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
CVS35_RS16315	COG0560	Phosphoserine phosphatase
CVS35_RS16320	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CVS35_RS16330	COG2199	diguanylate cyclase activity
CVS35_RS16330	COG3287	FIST C domain
CVS35_RS16330	COG2200	EAL domain
CVS35_RS16355	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CVS35_RS16365	COG2200	EAL domain
CVS35_RS16370	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CVS35_RS16375	COG0736	holo-[acyl-carrier-protein] synthase activity
CVS35_RS16380	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CVS35_RS16385	COG1381	Involved in DNA repair and RecF pathway recombination
CVS35_RS16390	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CVS35_RS16395	COG0571	ribonuclease III activity
CVS35_RS16405	COG0481	GTPase activity
CVS35_RS16410	COG3086	response to oxidative stress
CVS35_RS16415	COG3026	antisigma factor binding
CVS35_RS16430	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CVS35_RS16435	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CVS35_RS16440	COG0513	Belongs to the DEAD box helicase family
CVS35_RS16445	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
CVS35_RS16450	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CVS35_RS16470	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CVS35_RS16495	COG1902	pentaerythritol trinitrate reductase activity
CVS35_RS16500	COG0667	Aldo Keto reductase
CVS35_RS16515	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CVS35_RS16520	COG4208	sulfate ABC transporter
CVS35_RS16530	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CVS35_RS16535	COG3835	regulator
CVS35_RS16540	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CVS35_RS16545	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CVS35_RS16550	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CVS35_RS16555	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CVS35_RS16565	COG0316	Belongs to the HesB IscA family
CVS35_RS16570	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CVS35_RS16575	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CVS35_RS16585	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CVS35_RS16590	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CVS35_RS16595	COG1120	ATPase activity
CVS35_RS16600	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CVS35_RS16605	COG1643	Atp-dependent helicase
CVS35_RS16610	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
CVS35_RS16615	COG1489	DNA binding
CVS35_RS16625	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CVS35_RS16635	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CVS35_RS16640	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CVS35_RS16645	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CVS35_RS16650	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CVS35_RS16655	COG0842	Transport permease protein
CVS35_RS16660	COG1131	(ABC) transporter
CVS35_RS16665	COG0288	reversible hydration of carbon dioxide
CVS35_RS16680	COG3842	ATPase activity
CVS35_RS16695	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CVS35_RS16700	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CVS35_RS16705	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CVS35_RS16710	COG1780	Probably involved in ribonucleotide reductase function
CVS35_RS16735	COG0328	RNA-DNA hybrid ribonuclease activity
CVS35_RS16740	COG2226	methyltransferase
CVS35_RS16745	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CVS35_RS16750	COG0741	lytic transglycosylase activity
CVS35_RS16750	COG1388	LysM domain
CVS35_RS16755	COG3021	interspecies interaction between organisms
CVS35_RS16785	COG0542	response to heat
CVS35_RS16795	COG0564	pseudouridine synthase activity
CVS35_RS16805	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CVS35_RS16810	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CVS35_RS16815	COG0077	Prephenate dehydratase
CVS35_RS16815	COG1605	Chorismate mutase
CVS35_RS16820	COG0287	Prephenate dehydrogenase
CVS35_RS16820	COG1605	Chorismate mutase
CVS35_RS16825	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CVS35_RS16830	COG3279	Response regulator of the LytR AlgR family
CVS35_RS16840	COG2264	protein methyltransferase activity
CVS35_RS16845	COG0335	large ribosomal subunit rRNA binding
CVS35_RS16850	COG0336	Belongs to the RNA methyltransferase TrmD family
CVS35_RS16855	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CVS35_RS16860	COG0228	four-way junction DNA binding
CVS35_RS16865	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CVS35_RS16870	COG4137	Cytochrome C assembly protein
CVS35_RS16875	COG1854	S-ribosylhomocysteine lyase activity
CVS35_RS16880	COG2918	glutathione biosynthetic process
CVS35_RS16885	COG1238	metal cluster binding
CVS35_RS16890	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CVS35_RS16915	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CVS35_RS16920	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CVS35_RS16925	COG2137	regulation of response to DNA damage stimulus
CVS35_RS16930	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CVS35_RS16935	COG1546	Belongs to the CinA family
CVS35_RS16960	COG2814	Major facilitator Superfamily
CVS35_RS16965	COG0583	DNA-binding transcription factor activity
CVS35_RS16970	COG2999	glutathione oxidoreductase activity
CVS35_RS17000	COG3209	COG3209 Rhs family protein
CVS35_RS17025	COG3209	COG3209 Rhs family protein
CVS35_RS17040	COG4974	Belongs to the 'phage' integrase family
CVS35_RS17045	COG0305	Participates in initiation and elongation during chromosome replication
CVS35_RS17045	COG0358	DNA primase activity
CVS35_RS17050	COG1476	TRANSCRIPTIONal
CVS35_RS17070	COG3209	COG3209 Rhs family protein
CVS35_RS17080	COG4974	Belongs to the 'phage' integrase family
CVS35_RS17085	COG0358	DNA primase activity
CVS35_RS17090	COG3620	sequence-specific DNA binding
CVS35_RS17120	COG4974	Belongs to the 'phage' integrase family
CVS35_RS17125	COG0358	DNA primase activity
CVS35_RS17130	COG1476	TRANSCRIPTIONal
CVS35_RS17175	COG3501	Rhs element vgr protein
CVS35_RS17215	COG3829	transcription factor binding
CVS35_RS17280	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CVS35_RS17355	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CVS35_RS17360	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CVS35_RS17370	COG1073	alpha beta
CVS35_RS17375	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
CVS35_RS17380	COG2195	Cleaves the N-terminal amino acid of tripeptides
CVS35_RS17385	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CVS35_RS17395	COG2226	methyltransferase
CVS35_RS17405	COG3034	peptidoglycan biosynthetic process
CVS35_RS17410	COG0121	glutamine amidotransferase
CVS35_RS17415	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CVS35_RS17420	COG1960	acyl-CoA dehydrogenase activity
CVS35_RS17430	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
CVS35_RS17435	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CVS35_RS17465	COG3501	Rhs element vgr protein
CVS35_RS17470	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
CVS35_RS17475	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
CVS35_RS17480	COG0235	Class ii aldolase
CVS35_RS17485	COG0436	Aminotransferase
CVS35_RS17500	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CVS35_RS17510	COG0765	amino acid transport
CVS35_RS17555	COG4175	Glycine betaine
CVS35_RS17560	COG4176	ABC-type proline glycine betaine transport system permease component
CVS35_RS17565	COG2113	Glycine betaine
CVS35_RS17570	COG0596	Alpha beta hydrolase
CVS35_RS17580	COG2706	6-phosphogluconolactonase activity
CVS35_RS17585	COG2814	Major facilitator Superfamily
CVS35_RS17590	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CVS35_RS17600	COG1846	Transcriptional regulator
CVS35_RS17605	COG1566	PFAM secretion protein HlyD family protein
CVS35_RS17610	COG2814	Major facilitator Superfamily
CVS35_RS17615	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CVS35_RS17625	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CVS35_RS17630	COG3118	belongs to the thioredoxin family
CVS35_RS17635	COG3148	PFAM DTW domain containing protein
CVS35_RS17640	COG1042	CoA-binding domain protein
CVS35_RS17640	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CVS35_RS17640	COG0045	succinate-CoA ligase (ADP-forming) activity
CVS35_RS17645	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CVS35_RS17650	COG5544	Lipoprotein
CVS35_RS17655	COG0477	Major facilitator Superfamily
CVS35_RS17690	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CVS35_RS17695	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CVS35_RS17700	COG2011	ABC-type metal ion transport system permease component
CVS35_RS17705	COG1464	Belongs to the NlpA lipoprotein family
CVS35_RS17715	COG1720	tRNA m6t6A37 methyltransferase activity
CVS35_RS17720	COG0442	prolyl-tRNA aminoacylation
CVS35_RS17730	COG1388	LysM domain
CVS35_RS17730	COG4942	peptidase
CVS35_RS17735	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CVS35_RS17740	COG0585	pseudouridine synthase activity
CVS35_RS17745	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CVS35_RS17750	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CVS35_RS17755	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
CVS35_RS17765	COG0765	amino acid transport
CVS35_RS17770	COG1126	abc transporter atp-binding protein
CVS35_RS17785	COG2895	sulfate adenylyltransferase (ATP) activity
CVS35_RS17790	COG0175	sulfate reduction
CVS35_RS17795	COG1648	precorrin-2 dehydrogenase activity
CVS35_RS17795	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CVS35_RS17800	COG0175	sulfate reduction
CVS35_RS17805	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CVS35_RS17810	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CVS35_RS17820	COG2200	EAL domain
CVS35_RS17840	COG0720	synthase
CVS35_RS17845	COG0602	queuosine metabolic process
CVS35_RS17850	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CVS35_RS17865	COG1028	Short-chain dehydrogenase reductase Sdr
CVS35_RS17870	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
CVS35_RS17895	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CVS35_RS17905	COG0148	phosphopyruvate hydratase activity
CVS35_RS17910	COG0504	CTP synthase activity
CVS35_RS17915	COG3956	TIGRFAM MazG family protein
CVS35_RS17920	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CVS35_RS17925	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CVS35_RS17935	COG1929	Belongs to the glycerate kinase type-1 family
CVS35_RS17940	COG2084	Dehydrogenase
CVS35_RS17950	COG4948	Mandelate Racemase Muconate Lactonizing
CVS35_RS17955	COG4948	Mandelate Racemase Muconate Lactonizing
CVS35_RS17960	COG2271	Major facilitator Superfamily
CVS35_RS17965	COG2721	sulfolactate sulfo-lyase activity
CVS35_RS17970	COG0840	transmembrane signaling receptor activity
CVS35_RS17985	COG3530	Putative quorum-sensing-regulated virulence factor
CVS35_RS17990	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CVS35_RS17995	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CVS35_RS17995	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CVS35_RS18000	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CVS35_RS18005	COG3025	triphosphatase activity
CVS35_RS18010	COG4991	sh3 domain protein
CVS35_RS18015	COG0617	tRNA 3'-terminal CCA addition
CVS35_RS18020	COG1968	undecaprenyl-diphosphatase activity
CVS35_RS18025	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CVS35_RS18030	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CVS35_RS18035	COG0840	transmembrane signaling receptor activity
CVS35_RS18040	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CVS35_RS18045	COG2105	PFAM AIG2 family protein
CVS35_RS18050	COG2911	Protein conserved in bacteria
CVS35_RS18055	COG0729	surface antigen
CVS35_RS18060	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CVS35_RS18065	COG1253	flavin adenine dinucleotide binding
CVS35_RS18075	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
CVS35_RS18080	COG1218	3'(2'),5'-bisphosphate nucleotidase
CVS35_RS18085	COG0737	Belongs to the 5'-nucleotidase family
CVS35_RS18100	COG3961	Belongs to the TPP enzyme family
CVS35_RS18105	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
CVS35_RS18110	COG0545	Peptidyl-prolyl cis-trans isomerase
CVS35_RS18115	COG3061	Opacity-associated protein A
CVS35_RS18125	COG0359	binds to the 23S rRNA
CVS35_RS18130	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CVS35_RS18135	COG2965	DNA replication, synthesis of RNA primer
CVS35_RS18140	COG0360	Binds together with S18 to 16S ribosomal RNA
CVS35_RS18145	COG1073	alpha beta
CVS35_RS18150	COG0840	transmembrane signaling receptor activity
CVS35_RS18155	COG1690	Belongs to the RtcB family
CVS35_RS18160	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CVS35_RS18180	COG3766	membrane
CVS35_RS18185	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CVS35_RS18190	COG0557	exoribonuclease II activity
CVS35_RS18195	COG1959	2 iron, 2 sulfur cluster binding
CVS35_RS18200	COG0840	transmembrane signaling receptor activity
CVS35_RS18210	COG2805	Type II/IV secretion system protein
CVS35_RS18215	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CVS35_RS18220	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CVS35_RS18225	COG0762	integral membrane protein
CVS35_RS18230	COG1872	DUF167
CVS35_RS18235	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CVS35_RS18240	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CVS35_RS18255	COG0583	DNA-binding transcription factor activity
CVS35_RS18280	COG2153	protein acetylation
CVS35_RS18285	COG0477	Major facilitator Superfamily
CVS35_RS18290	COG0204	Acyl-transferase
CVS35_RS18290	COG0318	PFAM AMP-dependent synthetase and ligase
CVS35_RS18295	COG0840	transmembrane signaling receptor activity
CVS35_RS18305	COG2186	Transcriptional regulator
CVS35_RS18315	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CVS35_RS18320	COG2723	6-phospho-beta-galactosidase activity
CVS35_RS18325	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CVS35_RS18330	COG1447	Phosphotransferase system cellobiose-specific component IIA
CVS35_RS18335	COG1609	Transcriptional regulator
CVS35_RS18340	COG1396	sequence-specific DNA binding
CVS35_RS18355	COG0583	DNA-binding transcription factor activity
CVS35_RS18360	COG0583	DNA-binding transcription factor activity
CVS35_RS18390	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CVS35_RS18400	COG2124	cytochrome p450
CVS35_RS18415	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CVS35_RS18430	COG1522	sequence-specific DNA binding
CVS35_RS18440	COG1448	Aminotransferase
CVS35_RS18445	COG1451	nucleotide metabolic process
CVS35_RS18470	COG1518	maintenance of DNA repeat elements
CVS35_RS18475	COG1203	CRISPR-associated helicase, Cas3
CVS35_RS18510	COG0432	Pfam Uncharacterised protein family UPF0047
CVS35_RS18515	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CVS35_RS18535	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CVS35_RS18555	COG0395	ABC-type sugar transport system, permease component
CVS35_RS18560	COG1175	transmembrane transport
CVS35_RS18565	COG3842	ATPase activity
CVS35_RS18570	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
CVS35_RS18590	COG2971	BadF BadG BcrA BcrD
CVS35_RS18605	COG1121	(ABC) transporter
CVS35_RS18610	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CVS35_RS18615	COG0803	Belongs to the bacterial solute-binding protein 9 family
CVS35_RS18620	COG1349	DNA-binding transcription factor activity
CVS35_RS18625	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CVS35_RS18630	COG3395	kinase activity
CVS35_RS18635	COG1454	alcohol dehydrogenase
CVS35_RS18640	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CVS35_RS18655	COG2731	YhcH YjgK YiaL family protein
CVS35_RS18665	COG1028	Short-chain dehydrogenase reductase Sdr
CVS35_RS18670	COG1882	Formate acetyltransferase
CVS35_RS18675	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CVS35_RS18690	COG1609	Transcriptional regulator
CVS35_RS18695	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CVS35_RS18710	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CVS35_RS18715	COG3112	Uncharacterised protein family (UPF0231)
CVS35_RS18730	COG0640	Transcriptional regulator
CVS35_RS18740	COG2207	Transcriptional regulator
CVS35_RS18745	COG2079	MmgE PrpD family protein
CVS35_RS18750	COG1073	alpha beta
CVS35_RS18760	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CVS35_RS18765	COG0508	dehydrogenase complex catalyzes the overall conversion of
CVS35_RS18770	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CVS35_RS18780	COG1113	amino acid transport
CVS35_RS18785	COG2211	Major facilitator Superfamily
CVS35_RS18790	COG3940	Belongs to the glycosyl hydrolase 43 family
CVS35_RS18795	COG3725	Membrane protein required for beta-lactamase induction
CVS35_RS18800	COG3023	N-Acetylmuramoyl-L-alanine amidase
CVS35_RS18805	COG3248	Nucleoside-binding outer membrane protein
CVS35_RS18810	COG0157	Belongs to the NadC ModD family
CVS35_RS18815	COG4969	Belongs to the N-Me-Phe pilin family
CVS35_RS18820	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CVS35_RS18825	COG1459	type II secretion system
CVS35_RS18830	COG0516	GMP reductase activity
CVS35_RS18835	COG0237	dephospho-CoA kinase activity
CVS35_RS18840	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
CVS35_RS18845	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
CVS35_RS18850	COG0494	nUDIX hydrolase
CVS35_RS18855	COG0653	protein targeting
CVS35_RS18870	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
CVS35_RS18875	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CVS35_RS18880	COG0849	cell division
CVS35_RS18885	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CVS35_RS18890	COG1181	Belongs to the D-alanine--D-alanine ligase family
CVS35_RS18895	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CVS35_RS18900	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CVS35_RS18905	COG0772	Belongs to the SEDS family
CVS35_RS18910	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CVS35_RS18915	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CVS35_RS18920	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CVS35_RS18925	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CVS35_RS18930	COG0768	penicillin binding
CVS35_RS18935	COG3116	cell division
CVS35_RS18940	COG0275	rRNA processing
CVS35_RS18945	COG2001	Belongs to the MraZ family
CVS35_RS18965	COG0028	Belongs to the TPP enzyme family
CVS35_RS18970	COG1022	Amp-dependent synthetase and ligase
CVS35_RS18975	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CVS35_RS18980	COG0473	3-isopropylmalate dehydrogenase activity
CVS35_RS18985	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CVS35_RS18990	COG0066	3-isopropylmalate dehydratase activity
CVS35_RS19010	COG0840	transmembrane signaling receptor activity
CVS35_RS19035	COG4533	DNA binding
CVS35_RS19050	COG4143	(ABC) transporter
CVS35_RS19055	COG1178	ABC-type Fe3 transport system permease component
CVS35_RS19060	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
CVS35_RS19065	COG3507	Belongs to the glycosyl hydrolase 43 family
CVS35_RS19075	COG0028	Belongs to the TPP enzyme family
CVS35_RS19080	COG0440	acetolactate synthase activity
CVS35_RS19085	COG0586	Pfam SNARE associated Golgi protein
CVS35_RS19090	COG3706	GGDEF domain
CVS35_RS19095	COG0417	DNA replication proofreading
CVS35_RS19100	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CVS35_RS19105	COG0564	pseudouridine synthase activity
CVS35_RS19110	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CVS35_RS19115	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CVS35_RS19120	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CVS35_RS19125	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CVS35_RS19130	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CVS35_RS19135	COG2967	ApaG domain
CVS35_RS19140	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CVS35_RS19160	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CVS35_RS19165	COG3610	response to peptide
CVS35_RS19170	COG2966	Psort location CytoplasmicMembrane, score
CVS35_RS19180	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CVS35_RS19185	COG0505	Belongs to the CarA family
CVS35_RS19190	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CVS35_RS19195	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CVS35_RS19200	COG1047	Peptidyl-prolyl cis-trans
CVS35_RS19210	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CVS35_RS19215	COG0196	riboflavin kinase activity
CVS35_RS19220	COG0268	Binds directly to 16S ribosomal RNA
CVS35_RS19225	COG0583	DNA-binding transcription factor activity
CVS35_RS19230	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CVS35_RS19235	COG0484	heat shock protein binding
CVS35_RS19240	COG0443	Heat shock 70 kDa protein
CVS35_RS19245	COG1584	GPR1 FUN34 yaaH family protein
CVS35_RS19255	COG0521	Mo-molybdopterin cofactor biosynthetic process
CVS35_RS19265	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CVS35_RS19270	COG3022	response to hydroperoxide
CVS35_RS19280	COG0083	homoserine kinase activity
CVS35_RS19295	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
CVS35_RS19300	COG0745	RESPONSE REGULATOR receiver
CVS35_RS19305	COG3045	CreA protein
CVS35_RS19315	COG2207	Transcriptional regulator
CVS35_RS19315	COG3708	Transcriptional regulator
CVS35_RS19325	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
CVS35_RS19330	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
CVS35_RS19340	COG0488	(ABC) transporter
CVS35_RS19345	COG0840	transmembrane signaling receptor activity
CVS35_RS19350	COG0583	DNA-binding transcription factor activity
CVS35_RS19355	COG0604	alcohol dehydrogenase
CVS35_RS19360	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CVS35_RS19365	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CVS35_RS19370	COG0583	DNA-binding transcription factor activity
CVS35_RS19380	COG1279	arginine transmembrane transporter activity
CVS35_RS19385	COG0668	transmembrane transport
CVS35_RS19390	COG0191	fructose-bisphosphate aldolase activity
CVS35_RS19395	COG0126	phosphoglycerate kinase activity
CVS35_RS19400	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CVS35_RS19405	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CVS35_RS19410	COG0501	Belongs to the peptidase M48B family
CVS35_RS19420	COG1166	arginine decarboxylase activity
CVS35_RS19425	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CVS35_RS19430	COG3091	SprT-like family
CVS35_RS19435	COG2356	endonuclease I
CVS35_RS19440	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CVS35_RS19445	COG0189	ligase activity
CVS35_RS19450	COG1678	Uncharacterized ACR, COG1678
CVS35_RS19455	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CVS35_RS19460	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
CVS35_RS19465	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CVS35_RS19470	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CVS35_RS19475	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
CVS35_RS19480	COG0330	HflC and HflK could
CVS35_RS19485	COG0330	HflC and HflK could
CVS35_RS19490	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CVS35_RS19495	COG1923	regulation of RNA biosynthetic process
CVS35_RS19500	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CVS35_RS19505	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CVS35_RS19510	COG0860	N-Acetylmuramoyl-L-alanine amidase
CVS35_RS19515	COG0802	atpase or kinase
CVS35_RS19520	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CVS35_RS19520	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CVS35_RS19525	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CVS35_RS19540	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
CVS35_RS19555	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CVS35_RS19565	COG1064	alcohol dehydrogenase
CVS35_RS19585	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
CVS35_RS19590	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CVS35_RS19600	COG1011	Hydrolase
CVS35_RS19605	COG2814	Major facilitator Superfamily
CVS35_RS19645	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CVS35_RS19650	COG1162	GTPase activity
CVS35_RS19655	COG0688	phosphatidylethanolamine metabolic process
CVS35_RS19660	COG3264	Mechanosensitive ion channel
CVS35_RS19660	COG1511	domain protein
CVS35_RS19665	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
CVS35_RS19670	COG1053	succinate dehydrogenase
CVS35_RS19675	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CVS35_RS19680	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
CVS35_RS19685	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
CVS35_RS19690	COG3040	lipid binding
CVS35_RS19705	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CVS35_RS19710	COG1509	lysine 2,3-aminomutase activity
CVS35_RS19720	COG0166	Belongs to the GPI family
CVS35_RS19725	COG0527	aspartate kinase activity
CVS35_RS19735	COG0471	metal ion transport
CVS35_RS19745	COG4977	sequence-specific DNA binding
CVS35_RS19745	COG1917	Cupin 2, conserved barrel domain protein
CVS35_RS19750	COG1410	methionine synthase
CVS35_RS19750	COG0646	methionine synthase
CVS35_RS19760	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
CVS35_RS19770	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CVS35_RS19775	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
CVS35_RS19805	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CVS35_RS19815	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CVS35_RS19820	COG0009	L-threonylcarbamoyladenylate synthase
CVS35_RS19825	COG2922	Belongs to the Smg family
CVS35_RS19830	COG0758	DNA mediated transformation
CVS35_RS19835	COG0242	peptide deformylase activity
CVS35_RS19840	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CVS35_RS19845	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CVS35_RS19845	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CVS35_RS19850	COG0569	domain protein
CVS35_RS19855	COG1970	mechanosensitive ion channel activity
CVS35_RS19860	COG3036	rescue of stalled ribosome
CVS35_RS19865	COG0203	ribosomal protein L17
CVS35_RS19870	COG0202	RNA polymerase activity
CVS35_RS19875	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CVS35_RS19885	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CVS35_RS19890	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CVS35_RS19895	COG0201	protein transport
CVS35_RS19900	COG0200	Binds to the 23S rRNA
CVS35_RS19905	COG1841	ribosomal large subunit assembly
CVS35_RS19910	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CVS35_RS19915	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CVS35_RS19920	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CVS35_RS19925	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CVS35_RS19930	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CVS35_RS19935	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CVS35_RS19940	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CVS35_RS19950	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CVS35_RS19955	COG0255	Belongs to the universal ribosomal protein uL29 family
CVS35_RS19960	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CVS35_RS19965	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CVS35_RS19970	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CVS35_RS19975	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CVS35_RS19980	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CVS35_RS19985	COG0089	rRNA binding
CVS35_RS19990	COG0088	Forms part of the polypeptide exit tunnel
CVS35_RS19995	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CVS35_RS20000	COG0051	transcription antitermination factor activity, RNA binding
CVS35_RS20015	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CVS35_RS20020	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CVS35_RS20025	COG0049	tRNA binding
CVS35_RS20030	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CVS35_RS20035	COG2168	tRNA wobble position uridine thiolation
CVS35_RS20040	COG2923	Belongs to the DsrF TusC family
CVS35_RS20045	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
CVS35_RS20050	COG2964	Protein conserved in bacteria
CVS35_RS20060	COG0745	RESPONSE REGULATOR receiver
CVS35_RS20065	COG0642	Histidine kinase
CVS35_RS20070	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CVS35_RS20085	COG0545	Peptidyl-prolyl cis-trans isomerase
CVS35_RS20090	COG2900	Belongs to the SlyX family
CVS35_RS20095	COG1733	regulation of RNA biosynthetic process
CVS35_RS20110	COG1047	Peptidyl-prolyl cis-trans
CVS35_RS20115	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
CVS35_RS20120	COG0475	glutathione-regulated potassium exporter activity
CVS35_RS20120	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CVS35_RS20125	COG2249	NAD(P)H dehydrogenase (quinone) activity
CVS35_RS20130	COG0488	(ABC) transporter
CVS35_RS20140	COG0429	hydrolase of the alpha beta-hydrolase fold
CVS35_RS20145	COG3089	Belongs to the UPF0270 family
CVS35_RS20150	COG3954	Phosphoribulokinase
CVS35_RS20155	COG1765	OsmC-like protein
CVS35_RS20160	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CVS35_RS20175	COG3866	Pectate lyase
CVS35_RS20185	COG3866	Pectate lyase
CVS35_RS20190	COG3866	Pectate lyase
CVS35_RS20200	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CVS35_RS20205	COG4608	Belongs to the ABC transporter superfamily
CVS35_RS20210	COG0444	Belongs to the ABC transporter superfamily
CVS35_RS20215	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CVS35_RS20220	COG0601	transmembrane transport
CVS35_RS20225	COG0747	negative chemotaxis
CVS35_RS20230	COG4948	Mandelate Racemase Muconate Lactonizing
CVS35_RS20245	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CVS35_RS20255	COG1648	precorrin-2 dehydrogenase activity
CVS35_RS20255	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CVS35_RS20280	COG1473	amidohydrolase
CVS35_RS20285	COG0180	Tryptophanyl-tRNA synthetase
CVS35_RS20290	COG0546	phosphoglycolate phosphatase activity
CVS35_RS20295	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CVS35_RS20310	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CVS35_RS20315	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CVS35_RS20320	COG4796	Type ii and iii secretion system protein
CVS35_RS20345	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CVS35_RS20350	COG0494	nUDIX hydrolase
CVS35_RS20365	COG1011	Hydrolase
CVS35_RS20370	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CVS35_RS20375	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CVS35_RS20380	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CVS35_RS20405	COG2814	Major facilitator Superfamily
CVS35_RS20410	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CVS35_RS20415	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CVS35_RS20420	COG0019	diaminopimelate decarboxylase activity
CVS35_RS20425	COG4774	siderophore transport
CVS35_RS20430	COG4264	IucA IucC family
CVS35_RS20440	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CVS35_RS20450	COG0840	transmembrane signaling receptor activity
CVS35_RS20460	COG2183	response to ionizing radiation
CVS35_RS20465	COG1414	Transcriptional regulator
CVS35_RS20490	COG1136	(ABC) transporter
CVS35_RS20500	COG1785	Belongs to the alkaline phosphatase family
CVS35_RS20505	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CVS35_RS20510	COG2267	carboxylic ester hydrolase activity
CVS35_RS20515	COG1040	competence protein
CVS35_RS20520	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CVS35_RS20520	COG0316	Belongs to the HesB IscA family
CVS35_RS20525	COG1640	4-alpha-glucanotransferase
CVS35_RS20530	COG0058	SHG alpha-glucan phosphorylase activity
CVS35_RS20535	COG1349	DNA-binding transcription factor activity
CVS35_RS20540	COG0705	Rhomboid family
CVS35_RS20545	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CVS35_RS20555	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CVS35_RS20560	COG3501	Rhs element vgr protein
CVS35_RS20590	COG0058	SHG alpha-glucan phosphorylase activity
CVS35_RS20595	COG0297	glycogen (starch) synthase activity
CVS35_RS20600	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CVS35_RS20605	COG1523	belongs to the glycosyl hydrolase 13 family
CVS35_RS20610	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CVS35_RS20615	COG3275	phosphorelay sensor kinase activity
CVS35_RS20630	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CVS35_RS20635	COG2095	MarC family integral membrane protein
CVS35_RS20665	COG1741	Belongs to the pirin family
CVS35_RS20675	COG0247	lactate metabolic process
CVS35_RS20680	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
CVS35_RS20685	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CVS35_RS20690	COG2271	Major facilitator Superfamily
CVS35_RS20695	COG0584	glycerophosphoryl diester phosphodiesterase
CVS35_RS20700	COG0561	phosphatase activity
CVS35_RS20705	COG2267	carboxylic ester hydrolase activity
CVS35_RS20710	COG1280	lysine exporter protein (LysE YggA)
CVS35_RS20715	COG1280	lysine exporter protein (LysE YggA)
CVS35_RS20720	COG0514	ATP-dependent DNA helicase (RecQ)
CVS35_RS20735	COG2050	protein possibly involved in aromatic compounds catabolism
CVS35_RS20745	COG3180	Ammonia monooxygenase
CVS35_RS20750	COG0598	Magnesium transport protein CorA
CVS35_RS20755	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CVS35_RS20760	COG0210	DNA helicase
CVS35_RS20765	COG1011	Hydrolase
CVS35_RS20780	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CVS35_RS20790	COG1965	Belongs to the frataxin family
CVS35_RS20805	COG0181	hydroxymethylbilane synthase activity
CVS35_RS20810	COG1587	Uroporphyrinogen-III synthase
CVS35_RS20815	COG2959	enzyme of heme biosynthesis
CVS35_RS20820	COG3071	HemY protein
CVS35_RS20825	COG1473	amidohydrolase
CVS35_RS20830	COG1126	abc transporter atp-binding protein
CVS35_RS20835	COG0765	amino acid transport
CVS35_RS20840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CVS35_RS20845	COG0456	acetyltransferase
CVS35_RS20850	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CVS35_RS20885	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
CVS35_RS20895	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CVS35_RS20900	COG2244	polysaccharide biosynthetic process
CVS35_RS20905	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CVS35_RS20910	COG0456	acetyltransferase
CVS35_RS20915	COG1088	dTDP-glucose 4,6-dehydratase activity
CVS35_RS20920	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CVS35_RS20925	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CVS35_RS20930	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
CVS35_RS20935	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CVS35_RS20940	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CVS35_RS20945	COG3118	belongs to the thioredoxin family
CVS35_RS20950	COG0513	Belongs to the DEAD box helicase family
CVS35_RS20955	COG0248	Ppx GppA phosphatase
CVS35_RS20965	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CVS35_RS20970	COG0506	proline dehydrogenase activity
CVS35_RS20970	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CVS35_RS20970	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CVS35_RS20980	COG0583	DNA-binding transcription factor activity
CVS35_RS20990	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CVS35_RS20995	COG0583	DNA-binding transcription factor activity
CVS35_RS21015	COG0129	dihydroxy-acid dehydratase activity
CVS35_RS21025	COG3978	acetolactate synthase activity
CVS35_RS21040	COG0606	chelatase, subunit chli
CVS35_RS21045	COG3085	chromosome segregation
CVS35_RS21050	COG0583	DNA-binding transcription factor activity
CVS35_RS21055	COG1172	Belongs to the binding-protein-dependent transport system permease family
CVS35_RS21060	COG1172	Belongs to the binding-protein-dependent transport system permease family
CVS35_RS21065	COG1129	ABC transporter
CVS35_RS21070	COG1879	ABC-type sugar transport system periplasmic component
CVS35_RS21110	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CVS35_RS21115	COG4206	TonB-dependent receptor
CVS35_RS21120	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CVS35_RS21130	COG1309	transcriptional regulator
CVS35_RS21135	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CVS35_RS21150	COG3547	Transposase (IS116 IS110 IS902 family)
CVS35_RS21155	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CVS35_RS21160	COG1609	Transcriptional regulator
CVS35_RS21165	COG0395	ABC-type sugar transport system, permease component
CVS35_RS21180	COG3842	ATPase activity
CVS35_RS21185	COG0460	homoserine dehydrogenase
CVS35_RS21185	COG0527	aspartate kinase activity
CVS35_RS21190	COG0626	cystathionine gamma-synthase activity
CVS35_RS21195	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
CVS35_RS21200	COG1120	ATPase activity
CVS35_RS21210	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CVS35_RS21215	COG0254	rRNA binding
CVS35_RS21220	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CVS35_RS21225	COG1609	Transcriptional regulator
CVS35_RS21230	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CVS35_RS21235	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CVS35_RS21240	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CVS35_RS21245	COG1575	Belongs to the MenA family. Type 1 subfamily
CVS35_RS21250	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CVS35_RS21255	COG3074	FtsZ-dependent cytokinesis
CVS35_RS21260	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CVS35_RS21270	COG1494	fructose-1,6-bisphosphatase
CVS35_RS21280	COG3152	Membrane
CVS35_RS21290	COG0149	triose-phosphate isomerase activity
CVS35_RS21295	COG2957	Belongs to the agmatine deiminase family
CVS35_RS21300	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CVS35_RS21310	COG3501	Rhs element vgr protein
CVS35_RS21335	COG3620	sequence-specific DNA binding
CVS35_RS21340	COG0358	DNA primase activity
CVS35_RS21345	COG4974	Belongs to the 'phage' integrase family
CVS35_RS21365	COG4104	PAAR repeat-containing protein
CVS35_RS21365	COG3209	COG3209 Rhs family protein
CVS35_RS21380	COG1116	anion transmembrane transporter activity
CVS35_RS21385	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CVS35_RS21425	COG0583	DNA-binding transcription factor activity
CVS35_RS21430	COG0205	6-phosphofructokinase activity
CVS35_RS21435	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CVS35_RS21440	COG2814	Major facilitator Superfamily
CVS35_RS21445	COG3678	ATP-independent chaperone mediated protein folding
CVS35_RS21450	COG0745	RESPONSE REGULATOR receiver
CVS35_RS21455	COG2205	protein histidine kinase activity
CVS35_RS21470	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CVS35_RS21485	COG0584	glycerophosphoryl diester phosphodiesterase
CVS35_RS21490	COG3842	ATPase activity
CVS35_RS21495	COG0395	ABC-type sugar transport system, permease component
CVS35_RS21500	COG1175	transmembrane transport
CVS35_RS21505	COG1653	transport
CVS35_RS21520	COG1349	DNA-binding transcription factor activity
CVS35_RS21530	COG2084	Dehydrogenase
CVS35_RS21535	COG3395	kinase activity
CVS35_RS21540	COG0235	Class ii aldolase
CVS35_RS21545	COG3622	Belongs to the hyi family
CVS35_RS21550	COG2610	gluconate transmembrane transporter activity
CVS35_RS21555	COG0840	transmembrane signaling receptor activity
CVS35_RS21565	COG0840	transmembrane signaling receptor activity
CVS35_RS21575	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CVS35_RS21585	COG0411	ABC transporter
CVS35_RS21590	COG4177	L-phenylalanine transmembrane transporter activity
CVS35_RS21595	COG0559	Belongs to the binding-protein-dependent transport system permease family
CVS35_RS21600	COG0683	leucine binding
CVS35_RS21615	COG2177	Part of the ABC transporter FtsEX involved in
CVS35_RS21620	COG2884	Cell division ATP-binding protein ftsE
CVS35_RS21625	COG0552	protein localization to endoplasmic reticulum
CVS35_RS21630	COG0742	ribosomal rna small subunit methyltransferase
CVS35_RS21635	COG3776	membrane
CVS35_RS21650	COG3714	YhhN family
CVS35_RS21660	COG0425	Belongs to the sulfur carrier protein TusA family
CVS35_RS21665	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CVS35_RS21685	COG0477	Major facilitator Superfamily
CVS35_RS21690	COG1295	ribonuclease BN
CVS35_RS21695	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CVS35_RS21700	COG0612	Peptidase, M16
CVS35_RS21705	COG1301	dicarboxylic acid transport
CVS35_RS21710	COG2200	EAL domain
CVS35_RS21710	COG2199	diguanylate cyclase activity
CVS35_RS21735	COG1192	Involved in chromosome partitioning
CVS35_RS21750	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
CVS35_RS21755	COG3118	belongs to the thioredoxin family
CVS35_RS21755	COG0457	Tetratricopeptide repeat
CVS35_RS21775	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CVS35_RS21785	COG2271	Major facilitator Superfamily
CVS35_RS21790	COG1802	Transcriptional regulator
CVS35_RS21795	COG1063	alcohol dehydrogenase
CVS35_RS21815	COG3977	Valine--pyruvate aminotransferase
CVS35_RS21825	COG2723	6-phospho-beta-galactosidase activity
CVS35_RS21830	COG2190	(PTS) system
CVS35_RS21830	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CVS35_RS21830	COG1263	PTS System
CVS35_RS21835	COG3711	transcriptional antiterminator
CVS35_RS21845	COG4608	Belongs to the ABC transporter superfamily
CVS35_RS21850	COG0444	Belongs to the ABC transporter superfamily
CVS35_RS21855	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CVS35_RS21860	COG0601	transmembrane transport
CVS35_RS21865	COG0747	negative chemotaxis
CVS35_RS21875	COG3493	citrate carrier protein
CVS35_RS21890	COG4565	transcriptional regulatory protein
CVS35_RS21895	COG3290	protein histidine kinase activity
CVS35_RS21900	COG0471	metal ion transport
CVS35_RS21905	COG2985	domain, Protein
CVS35_RS21905	COG0569	domain protein
CVS35_RS21910	COG0071	Belongs to the small heat shock protein (HSP20) family
CVS35_RS21915	COG0071	Belongs to the small heat shock protein (HSP20) family
CVS35_RS21920	COG5645	(Lipo)protein
CVS35_RS21925	COG0823	Involved in the tonB-independent uptake of proteins
CVS35_RS21935	COG2723	6-phospho-beta-galactosidase activity
CVS35_RS21940	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CVS35_RS21940	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CVS35_RS21950	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CVS35_RS21955	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CVS35_RS21960	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CVS35_RS21965	COG1116	anion transmembrane transporter activity
CVS35_RS21975	COG2271	Major facilitator Superfamily
CVS35_RS21985	COG4948	Mandelate Racemase Muconate Lactonizing
CVS35_RS21990	COG0800	Aldolase
CVS35_RS21995	COG3734	2-keto-3-deoxy-galactonokinase
CVS35_RS22000	COG2186	Transcriptional regulator
CVS35_RS22005	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
CVS35_RS22020	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CVS35_RS22025	COG0601	transmembrane transport
CVS35_RS22040	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CVS35_RS22045	COG0747	negative chemotaxis
CVS35_RS22055	COG0561	phosphatase activity
CVS35_RS22075	COG2723	6-phospho-beta-galactosidase activity
CVS35_RS22080	COG1447	Phosphotransferase system cellobiose-specific component IIA
CVS35_RS22085	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CVS35_RS22095	COG1609	Transcriptional regulator
CVS35_RS22110	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CVS35_RS22115	COG0592	DNA-directed DNA polymerase activity
CVS35_RS22120	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CVS35_RS22125	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CVS35_RS22130	COG0594	ribonuclease P activity
CVS35_RS22140	COG0706	membrane insertase activity
CVS35_RS22145	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CVS35_RS22160	COG0702	epimerase
CVS35_RS22165	COG1733	regulation of RNA biosynthetic process
CVS35_RS22175	COG1215	transferase activity, transferring glycosyl groups
CVS35_RS22180	COG0726	polysaccharide deacetylase
CVS35_RS22180	COG1649	PFAM Uncharacterised BCR, COG1649
CVS35_RS22185	COG0457	Tetratricopeptide repeat
CVS35_RS22220	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CVS35_RS22220	COG0493	'glutamate synthase
CVS35_RS22225	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CVS35_RS22230	COG2091	lysine biosynthetic process via aminoadipic acid
CVS35_RS22235	COG2252	PERMEase
CVS35_RS22245	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CVS35_RS22250	COG0765	amino acid transport
CVS35_RS22255	COG0765	amino acid transport
CVS35_RS22260	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CVS35_RS22265	COG3135	benzoate transporter
CVS35_RS22270	COG1396	sequence-specific DNA binding
CVS35_RS22280	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CVS35_RS22285	COG0581	inorganic phosphate transmembrane transporter activity
CVS35_RS22290	COG0573	inorganic phosphate transmembrane transporter activity
CVS35_RS22295	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CVS35_RS22300	COG1126	abc transporter atp-binding protein
CVS35_RS22305	COG0765	amino acid transport
CVS35_RS22315	COG4221	oxidoreductase activity
CVS35_RS22330	COG0436	Aminotransferase
CVS35_RS22335	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CVS35_RS22340	COG1984	allophanate hydrolase subunit 2
CVS35_RS22350	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CVS35_RS22355	COG0697	spore germination
CVS35_RS22360	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CVS35_RS22365	COG1028	Short-chain dehydrogenase reductase Sdr
CVS35_RS22375	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CVS35_RS22400	COG1216	Glycosyl transferase, family 2
CVS35_RS22405	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CVS35_RS22410	COG0318	PFAM AMP-dependent synthetase and ligase
CVS35_RS22420	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CVS35_RS22425	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CVS35_RS22445	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CVS35_RS22450	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CVS35_RS22460	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CVS35_RS22465	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CVS35_RS22470	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CVS35_RS22475	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CVS35_RS22480	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CVS35_RS22485	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CVS35_RS22495	COG0356	it plays a direct role in the translocation of protons across the membrane
CVS35_RS22500	COG3312	ion transport
CVS35_RS22505	COG0357	Ribosomal RNA small subunit methyltransferase G
CVS35_RS22510	COG0445	tRNA wobble uridine modification