locus-tag	class	description
EV46_RS00005	COG0716	FMN binding
EV46_RS00010	COG1522	sequence-specific DNA binding
EV46_RS00015	COG2502	aspartate--ammonia ligase
EV46_RS00020	COG2425	protein containing a von Willebrand factor type A (vWA) domain
EV46_RS00025	COG0714	Associated with various cellular activities
EV46_RS00030	COG3158	transport of potassium into the cell
EV46_RS00035	COG0642	Histidine kinase
EV46_RS00045	COG3111	PFAM Bacterial OB fold (BOF) protein
EV46_RS00050	COG1869	D-ribose catabolic process
EV46_RS00055	COG1129	ABC transporter
EV46_RS00060	COG1172	Belongs to the binding-protein-dependent transport system permease family
EV46_RS00070	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EV46_RS00075	COG1609	Transcriptional regulator
EV46_RS00100	COG1763	Mo-molybdopterin cofactor biosynthetic process
EV46_RS00105	COG0746	molybdenum cofactor guanylyltransferase activity
EV46_RS00110	COG3084	Protein conserved in bacteria
EV46_RS00115	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EV46_RS00125	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EV46_RS00125	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EV46_RS00130	COG0218	Necessary for normal cell division and for the maintenance of normal septation
EV46_RS00135	COG3078	GTPase activator activity
EV46_RS00140	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EV46_RS00150	COG3852	Histidine kinase
EV46_RS00165	COG1011	Hydrolase
EV46_RS00170	COG1490	D-aminoacyl-tRNA deacylase activity
EV46_RS00175	COG0456	acetyltransferase
EV46_RS00180	COG2982	Protein involved in outer membrane biogenesis
EV46_RS00185	COG2233	PERMEase
EV46_RS00190	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EV46_RS00195	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EV46_RS00200	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EV46_RS00205	COG1758	RNA polymerase activity
EV46_RS00210	COG0194	GDP metabolic process
EV46_RS00220	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EV46_RS00225	COG2194	sulfuric ester hydrolase activity
EV46_RS00240	COG2200	EAL domain
EV46_RS00245	COG2081	HI0933 family
EV46_RS00250	COG0306	phosphate transporter
EV46_RS00260	COG0589	response to stress
EV46_RS00265	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EV46_RS00275	COG0737	Belongs to the 5'-nucleotidase family
EV46_RS00280	COG0742	ribosomal rna small subunit methyltransferase
EV46_RS00290	COG1629	transport
EV46_RS00295	COG1595	DNA-templated transcription, initiation
EV46_RS00300	COG3712	iron ion homeostasis
EV46_RS00315	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
EV46_RS00320	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EV46_RS00340	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EV46_RS00345	COG1280	lysine exporter protein (LysE YggA)
EV46_RS00350	COG0583	DNA-binding transcription factor activity
EV46_RS00355	COG3479	Phenolic acid decarboxylase
EV46_RS00365	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EV46_RS00370	COG4172	Belongs to the ABC transporter superfamily
EV46_RS00375	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EV46_RS00385	COG4166	transmembrane transport
EV46_RS00395	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EV46_RS00400	COG0840	transmembrane signaling receptor activity
EV46_RS00405	COG0456	acetyltransferase
EV46_RS00410	COG2818	Glycosylase
EV46_RS00415	COG0730	response to heat
EV46_RS00420	COG0752	glycyl-tRNA synthetase alpha subunit
EV46_RS00425	COG0751	glycine-tRNA ligase activity
EV46_RS00450	COG2213	PTS system mannitol-specific
EV46_RS00450	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
EV46_RS00455	COG0246	Mannitol dehydrogenase
EV46_RS00460	COG3722	fumarate hydratase activity
EV46_RS00470	COG0840	transmembrane signaling receptor activity
EV46_RS00475	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EV46_RS00480	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EV46_RS00485	COG1012	belongs to the aldehyde dehydrogenase family
EV46_RS00490	COG3274	enterobacterial common antigen metabolic process
EV46_RS00495	COG1070	Carbohydrate kinase
EV46_RS00500	COG2115	Belongs to the xylose isomerase family
EV46_RS00505	COG4213	ABC transporter substrate-binding protein
EV46_RS00510	COG1129	ABC transporter
EV46_RS00515	COG4214	carbohydrate transport
EV46_RS00520	COG2207	Transcriptional regulator
EV46_RS00520	COG1609	Transcriptional regulator
EV46_RS00530	COG0137	argininosuccinate synthase activity
EV46_RS00535	COG3916	Acyl-homoserine-lactone synthase
EV46_RS00540	COG2771	luxR family
EV46_RS00545	COG4677	pectinesterase activity
EV46_RS00550	COG3136	membrane protein required for alginate biosynthesis
EV46_RS00555	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EV46_RS00560	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EV46_RS00590	COG3239	Fatty acid desaturase
EV46_RS00600	COG1012	belongs to the aldehyde dehydrogenase family
EV46_RS00605	COG1304	FMN binding
EV46_RS00610	COG0628	permease
EV46_RS00665	COG3423	Transcriptional regulator
EV46_RS00680	COG3727	T/G mismatch-specific endonuclease activity
EV46_RS00690	COG1561	YicC-like family, N-terminal region
EV46_RS00695	COG0583	DNA-binding transcription factor activity
EV46_RS00700	COG1446	asparaginase
EV46_RS00715	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EV46_RS00720	COG0601	transmembrane transport
EV46_RS00725	COG0747	negative chemotaxis
EV46_RS00730	COG4172	Belongs to the ABC transporter superfamily
EV46_RS00735	COG4948	Mandelate Racemase Muconate Lactonizing
EV46_RS00740	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
EV46_RS00745	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
EV46_RS00750	COG1309	transcriptional regulator
EV46_RS00755	COG0756	dUTP diphosphatase activity
EV46_RS00760	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EV46_RS00765	COG2003	Belongs to the UPF0758 family
EV46_RS00770	COG0227	Belongs to the bacterial ribosomal protein bL28 family
EV46_RS00780	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
EV46_RS00785	COG0859	PFAM glycosyl transferase family 9
EV46_RS00790	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
EV46_RS00795	COG1519	Transferase
EV46_RS00810	COG3306	glycosyltransferase involved in LPS biosynthesis
EV46_RS00830	COG0438	transferase activity, transferring glycosyl groups
EV46_RS00835	COG0859	PFAM glycosyl transferase family 9
EV46_RS00840	COG3307	-O-antigen
EV46_RS00845	COG3307	-O-antigen
EV46_RS00850	COG0859	PFAM glycosyl transferase family 9
EV46_RS00860	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EV46_RS00865	COG0156	8-amino-7-oxononanoate synthase activity
EV46_RS00870	COG1063	alcohol dehydrogenase
EV46_RS00875	COG2861	carbohydrate metabolic process
EV46_RS00880	COG4942	peptidase
EV46_RS00885	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EV46_RS00890	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
EV46_RS00895	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EV46_RS00900	COG1045	serine acetyltransferase
EV46_RS00910	COG3157	Type VI secretion system effector, Hcp
EV46_RS00930	COG0583	DNA-binding transcription factor activity
EV46_RS00935	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EV46_RS00940	COG0840	transmembrane signaling receptor activity
EV46_RS00945	COG0840	transmembrane signaling receptor activity
EV46_RS00950	COG0412	Dienelactone hydrolase
EV46_RS00965	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
EV46_RS00970	COG1263	PTS System
EV46_RS00970	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EV46_RS00970	COG2190	(PTS) system
EV46_RS00975	COG4948	Mandelate Racemase Muconate Lactonizing
EV46_RS00980	COG2188	Transcriptional regulator
EV46_RS00985	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EV46_RS00990	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
EV46_RS00995	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EV46_RS01000	COG0165	Argininosuccinate lyase
EV46_RS01005	COG1322	Protein conserved in bacteria
EV46_RS01010	COG2226	methyltransferase
EV46_RS01020	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EV46_RS01025	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EV46_RS01030	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EV46_RS01035	COG0805	protein transport
EV46_RS01040	COG0084	hydrolase, TatD family'
EV46_RS01050	COG0250	Participates in transcription elongation, termination and antitermination
EV46_RS01055	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
EV46_RS01065	COG0183	Belongs to the thiolase family
EV46_RS01070	COG1024	Enoyl-CoA hydratase
EV46_RS01070	COG1250	3-hydroxyacyl-CoA dehydrogenase
EV46_RS01075	COG0006	proline dipeptidase activity
EV46_RS01080	COG1739	Uncharacterized protein family UPF0029
EV46_RS01120	COG0812	UDP-N-acetylmuramate dehydrogenase activity
EV46_RS01125	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
EV46_RS01125	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
EV46_RS01130	COG1072	(Pantothenic acid kinase))
EV46_RS01170	COG0250	Participates in transcription elongation, termination and antitermination
EV46_RS01175	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EV46_RS01180	COG0081	regulation of translation
EV46_RS01185	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EV46_RS01190	COG0222	ribosome binding
EV46_RS01195	COG0085	RNA polymerase activity
EV46_RS01200	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EV46_RS01205	COG0477	Major facilitator Superfamily
EV46_RS01210	COG5457	Domain of unknown function (DUF1127)
EV46_RS01215	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EV46_RS01220	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EV46_RS01225	COG2022	thiamine diphosphate biosynthetic process
EV46_RS01230	COG2104	thiamine diphosphate biosynthetic process
EV46_RS01235	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EV46_RS01240	COG0352	thiamine-phosphate diphosphorylase activity
EV46_RS01245	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
EV46_RS01250	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
EV46_RS01255	COG2816	NAD+ diphosphatase activity
EV46_RS01260	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
EV46_RS01265	COG1515	deoxyribonuclease V activity
EV46_RS01285	COG0151	Belongs to the GarS family
EV46_RS01290	COG0138	bifunctional purine biosynthesis protein purh
EV46_RS01320	COG1126	abc transporter atp-binding protein
EV46_RS01325	COG0765	amino acid transport
EV46_RS01330	COG4597	amino acid ABC transporter
EV46_RS01335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EV46_RS01340	COG0765	amino acid transport
EV46_RS01345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EV46_RS01350	COG1733	regulation of RNA biosynthetic process
EV46_RS01385	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
EV46_RS01395	COG3338	carbonate dehydratase activity
EV46_RS01400	COG2264	protein methyltransferase activity
EV46_RS01405	COG4145	pantothenate transmembrane transporter activity
EV46_RS01410	COG3924	membrane
EV46_RS01415	COG0439	Biotin carboxylase
EV46_RS01420	COG0511	ligase activity, forming carbon-carbon bonds
EV46_RS01425	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EV46_RS01430	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
EV46_RS01435	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
EV46_RS01440	COG0604	alcohol dehydrogenase
EV46_RS01445	COG2200	EAL domain
EV46_RS01445	COG2199	diguanylate cyclase activity
EV46_RS01450	COG1077	Cell shape determining protein MreB Mrl
EV46_RS01455	COG1792	Involved in formation and maintenance of cell shape
EV46_RS01460	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
EV46_RS01465	COG0424	maF-like protein
EV46_RS01470	COG1530	ribonuclease E activity
EV46_RS01475	COG3164	Protein of unknown function
EV46_RS01480	COG0312	modulator of DNA gyrase
EV46_RS01495	COG0583	DNA-binding transcription factor activity
EV46_RS01505	COG1566	PFAM secretion protein HlyD family protein
EV46_RS01510	COG1289	transmembrane transporter activity
EV46_RS01520	COG3028	Belongs to the UPF0307 family
EV46_RS01525	COG0312	modulator of DNA gyrase
EV46_RS01530	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EV46_RS01535	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EV46_RS01540	COG1660	Displays ATPase and GTPase activities
EV46_RS01545	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EV46_RS01550	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
EV46_RS01555	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
EV46_RS01560	COG1137	ATPase activity
EV46_RS01565	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
EV46_RS01570	COG3117	lipopolysaccharide transmembrane transporter activity
EV46_RS01575	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
EV46_RS01580	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
EV46_RS01580	COG0517	IMP dehydrogenase activity
EV46_RS01585	COG0530	calcium, potassium:sodium antiporter activity
EV46_RS01590	COG1127	ABC transporter
EV46_RS01595	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EV46_RS01600	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EV46_RS01605	COG2854	intermembrane phospholipid transfer
EV46_RS01610	COG3113	response to antibiotic
EV46_RS01615	COG5007	Belongs to the BolA IbaG family
EV46_RS01620	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EV46_RS01625	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EV46_RS01630	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EV46_RS01635	COG3105	Protein conserved in bacteria
EV46_RS01640	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
EV46_RS01645	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EV46_RS01650	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EV46_RS01655	COG0625	glutathione transferase activity
EV46_RS01660	COG2969	positive regulation of protein catabolic process
EV46_RS01670	COG0493	'glutamate synthase
EV46_RS01675	COG0067	glutamate synthase
EV46_RS01675	COG0069	glutamate synthase activity
EV46_RS01675	COG0070	glutamate synthase
EV46_RS01680	COG1242	4 iron, 4 sulfur cluster binding
EV46_RS01685	COG5002	protein histidine kinase activity
EV46_RS01685	COG2198	Histidine kinase
EV46_RS01685	COG0784	Response regulator, receiver
EV46_RS01690	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
EV46_RS01695	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EV46_RS01705	COG2823	Periplasmic or secreted lipoprotein
EV46_RS01710	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
EV46_RS01715	COG0792	nuclease activity
EV46_RS01720	COG3107	peptidoglycan biosynthetic process
EV46_RS01725	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EV46_RS01730	COG3384	dioxygenase
EV46_RS01735	COG0754	glutathionylspermidine amidase activity
EV46_RS01740	COG5463	Belongs to the UPF0441 family
EV46_RS01745	COG1538	Outer membrane efflux protein
EV46_RS01750	COG0494	nUDIX hydrolase
EV46_RS01755	COG3151	Protein conserved in bacteria
EV46_RS01760	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
EV46_RS01765	COG3150	esterase
EV46_RS01770	COG0187	DNA topoisomerase II activity
EV46_RS01775	COG0583	DNA-binding transcription factor activity
EV46_RS01780	COG2249	NAD(P)H dehydrogenase (quinone) activity
EV46_RS01795	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EV46_RS01795	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EV46_RS01800	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EV46_RS01805	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EV46_RS01805	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EV46_RS01805	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EV46_RS01810	COG3711	transcriptional antiterminator
EV46_RS01810	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EV46_RS01820	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EV46_RS01825	COG0204	Acyl-transferase
EV46_RS01830	COG2132	Multicopper oxidase
EV46_RS01835	COG2188	Transcriptional regulator
EV46_RS01845	COG1979	alcohol dehydrogenase
EV46_RS01850	COG0778	Nitroreductase
EV46_RS01855	COG2207	Transcriptional regulator
EV46_RS01885	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EV46_RS01895	COG0848	biopolymer transport protein
EV46_RS01930	COG4680	protein conserved in bacteria
EV46_RS01950	COG2814	Major facilitator Superfamily
EV46_RS01960	COG3787	Belongs to the UPF0306 family
EV46_RS01965	COG0702	epimerase
EV46_RS01975	COG1328	CTP reductase activity
EV46_RS01995	COG2308	Evidence 4 Homologs of previously reported genes of
EV46_RS02005	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
EV46_RS02010	COG0540	Belongs to the ATCase OTCase family
EV46_RS02015	COG2731	YhcH YjgK YiaL family protein
EV46_RS02020	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
EV46_RS02040	COG0501	Belongs to the peptidase M48B family
EV46_RS02045	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EV46_RS02050	COG0840	transmembrane signaling receptor activity
EV46_RS02055	COG2831	hemolysin activation secretion protein
EV46_RS02060	COG3210	domain, Protein
EV46_RS02070	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
EV46_RS02110	COG0525	valine-tRNA ligase activity
EV46_RS02115	COG2927	DNA polymerase III (CHI subunit)
EV46_RS02120	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EV46_RS02125	COG0795	lipopolysaccharide-transporting ATPase activity
EV46_RS02130	COG0795	lipopolysaccharide-transporting ATPase activity
EV46_RS02140	COG2850	peptidyl-arginine hydroxylation
EV46_RS02160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EV46_RS02175	COG0583	DNA-binding transcription factor activity
EV46_RS02210	COG0840	transmembrane signaling receptor activity
EV46_RS02220	COG0840	transmembrane signaling receptor activity
EV46_RS02225	COG3254	rhamnose metabolic process
EV46_RS02230	COG0235	Class ii aldolase
EV46_RS02235	COG4806	L-rhamnose isomerase
EV46_RS02240	COG1070	Carbohydrate kinase
EV46_RS02245	COG1917	Cupin 2, conserved barrel domain protein
EV46_RS02245	COG2169	Transcriptional regulator
EV46_RS02250	COG1917	Cupin 2, conserved barrel domain protein
EV46_RS02250	COG4977	sequence-specific DNA binding
EV46_RS02255	COG4115	mRNA cleavage
EV46_RS02260	COG2161	toxin-antitoxin pair type II binding
EV46_RS02270	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EV46_RS02280	COG0747	negative chemotaxis
EV46_RS02285	COG3477	response to acidic pH
EV46_RS02300	COG2862	Uncharacterized protein family, UPF0114
EV46_RS02305	COG2130	NADP-dependent
EV46_RS02315	COG3157	Type VI secretion system effector, Hcp
EV46_RS02320	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EV46_RS02325	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EV46_RS02330	COG0006	proline dipeptidase activity
EV46_RS02335	COG3079	Belongs to the UPF0149 family
EV46_RS02340	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
EV46_RS02345	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EV46_RS02360	COG0560	Phosphoserine phosphatase
EV46_RS02365	COG3726	membrane protein affecting hemolysin expression
EV46_RS02375	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
EV46_RS02380	COG2823	Periplasmic or secreted lipoprotein
EV46_RS02390	COG0084	hydrolase, TatD family'
EV46_RS02395	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EV46_RS02405	COG4771	TonB-dependent receptor
EV46_RS02415	COG1169	isochorismate synthase
EV46_RS02420	COG1021	2,3-dihydroxybenzoate-AMP ligase
EV46_RS02425	COG1535	isochorismatase
EV46_RS02425	COG3433	isochorismatase activity
EV46_RS02430	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EV46_RS02435	COG1028	Short-chain dehydrogenase reductase Sdr
EV46_RS02445	COG3321	synthase
EV46_RS02445	COG1028	Short-chain dehydrogenase reductase Sdr
EV46_RS02445	COG0318	PFAM AMP-dependent synthetase and ligase
EV46_RS02445	COG0300	oxidoreductase activity
EV46_RS02445	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EV46_RS02465	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
EV46_RS02465	COG0028	Belongs to the TPP enzyme family
EV46_RS02470	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
EV46_RS02475	COG3624	Phosphonate C-P lyase system protein PhnG
EV46_RS02480	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
EV46_RS02485	COG3626	phosphonate metabolism
EV46_RS02490	COG3627	carbon phosphorus lyase activity
EV46_RS02495	COG4107	phosphonate C-P lyase system protein PhnK
EV46_RS02500	COG4778	phosphonate C-P lyase system protein PhnL
EV46_RS02505	COG3454	Phosphonate metabolism
EV46_RS02510	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
EV46_RS02515	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
EV46_RS02560	COG0438	transferase activity, transferring glycosyl groups
EV46_RS02575	COG1045	serine acetyltransferase
EV46_RS02590	COG3423	Transcriptional regulator
EV46_RS02615	COG1309	transcriptional regulator
EV46_RS02620	COG4232	protein-disulfide reductase activity
EV46_RS02625	COG1324	tolerance protein
EV46_RS02630	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
EV46_RS02645	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EV46_RS02650	COG0459	protein refolding
EV46_RS02655	COG3161	chorismate lyase activity
EV46_RS02660	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
EV46_RS02665	COG2937	Belongs to the GPAT DAPAT family
EV46_RS02670	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EV46_RS02675	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EV46_RS02680	COG3237	CsbD-like
EV46_RS02685	COG0735	belongs to the Fur family
EV46_RS02690	COG1741	Belongs to the pirin family
EV46_RS02695	COG0583	DNA-binding transcription factor activity
EV46_RS02700	COG0435	Glutathione S-transferase
EV46_RS02705	COG2259	Doxx family
EV46_RS02715	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
EV46_RS02720	COG4575	ribosome binding
EV46_RS02725	COG1422	Protein of unknown function (DUF1090)
EV46_RS02735	COG0586	Pfam SNARE associated Golgi protein
EV46_RS02745	COG2271	Major facilitator Superfamily
EV46_RS02750	COG1904	glucuronate isomerase
EV46_RS02755	COG0246	Mannitol dehydrogenase
EV46_RS02760	COG2721	sulfolactate sulfo-lyase activity
EV46_RS02770	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EV46_RS02780	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
EV46_RS02785	COG0861	Integral membrane protein TerC family
EV46_RS02790	COG0673	inositol 2-dehydrogenase activity
EV46_RS02795	COG2813	Specifically methylates the guanine in position
EV46_RS02800	COG0446	pyridine nucleotide-disulphide oxidoreductase
EV46_RS02800	COG1902	pentaerythritol trinitrate reductase activity
EV46_RS02815	COG2199	diguanylate cyclase activity
EV46_RS02845	COG3663	DNA glycosylase
EV46_RS02855	COG0358	DNA primase activity
EV46_RS02860	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EV46_RS02865	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
EV46_RS02870	COG1438	arginine binding
EV46_RS02875	COG0039	L-malate dehydrogenase activity
EV46_RS02880	COG3423	Transcriptional regulator
EV46_RS02895	COG0142	geranyltranstransferase activity
EV46_RS02900	COG0261	This protein binds to 23S rRNA in the presence of protein L20
EV46_RS02905	COG0211	Belongs to the bacterial ribosomal protein bL27 family
EV46_RS02910	COG0697	spore germination
EV46_RS02915	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EV46_RS02920	COG2027	D-alanyl-D-alanine carboxypeptidase
EV46_RS02930	COG1534	Rna-binding protein
EV46_RS02935	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
EV46_RS02940	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EV46_RS02945	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EV46_RS02950	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EV46_RS02955	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EV46_RS02985	COG0779	Required for maturation of 30S ribosomal subunits
EV46_RS02995	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EV46_RS03000	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EV46_RS03005	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
EV46_RS03010	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
EV46_RS03015	COG1185	polyribonucleotide nucleotidyltransferase activity
EV46_RS03025	COG0513	Belongs to the DEAD box helicase family
EV46_RS03030	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EV46_RS03035	COG0826	peptidase U32
EV46_RS03040	COG0826	peptidase U32
EV46_RS03045	COG3154	lipid carrier protein
EV46_RS03050	COG3153	acetyltransferase
EV46_RS03055	COG2827	Endonuclease containing a URI domain
EV46_RS03060	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
EV46_RS03065	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
EV46_RS03070	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
EV46_RS03075	COG0813	purine-nucleoside phosphorylase activity
EV46_RS03095	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
EV46_RS03100	COG2813	Specifically methylates the guanine in position
EV46_RS03105	COG0667	Aldo Keto reductase
EV46_RS03150	COG1454	alcohol dehydrogenase
EV46_RS03155	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EV46_RS03160	COG0509	glycine decarboxylation via glycine cleavage system
EV46_RS03165	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EV46_RS03165	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EV46_RS03170	COG1733	regulation of RNA biosynthetic process
EV46_RS03175	COG1028	Short-chain dehydrogenase reductase Sdr
EV46_RS03180	COG1175	transmembrane transport
EV46_RS03190	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
EV46_RS03200	COG1653	transport
EV46_RS03205	COG2211	Major facilitator Superfamily
EV46_RS03225	COG1272	protein, Hemolysin III
EV46_RS03230	COG0354	folic acid binding
EV46_RS03235	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
EV46_RS03245	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
EV46_RS03255	COG0716	FMN binding
EV46_RS03275	COG0477	Major facilitator Superfamily
EV46_RS03280	COG4974	Belongs to the 'phage' integrase family
EV46_RS03285	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EV46_RS03290	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EV46_RS03295	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
EV46_RS03300	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EV46_RS03330	COG4319	ketosteroid isomerase
EV46_RS03340	COG1560	Kdo2-lipid A biosynthetic process
EV46_RS03350	COG2252	PERMEase
EV46_RS03355	COG0025	NhaP-type Na H and K H
EV46_RS03365	COG5002	protein histidine kinase activity
EV46_RS03365	COG3850	Histidine kinase
EV46_RS03385	COG4964	Belongs to the GSP D family
EV46_RS03465	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EV46_RS03470	COG3162	membrane
EV46_RS03475	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EV46_RS03485	COG4774	siderophore transport
EV46_RS03495	COG1595	DNA-templated transcription, initiation
EV46_RS03500	COG3712	iron ion homeostasis
EV46_RS03525	COG0246	Mannitol dehydrogenase
EV46_RS03530	COG2873	o-acetylhomoserine
EV46_RS03535	COG1376	ErfK ybiS ycfS ynhG family protein
EV46_RS03540	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EV46_RS03545	COG3038	cytochrome b561
EV46_RS03550	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EV46_RS03550	COG1013	pyruvate-flavodoxin oxidoreductase activity
EV46_RS03550	COG0674	pyruvate-flavodoxin oxidoreductase activity
EV46_RS03550	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
EV46_RS03565	COG1280	lysine exporter protein (LysE YggA)
EV46_RS03570	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EV46_RS03575	COG2801	Transposase and inactivated derivatives
EV46_RS03610	COG2026	Addiction module toxin, RelE StbE family
EV46_RS03670	COG0582	viral genome integration into host DNA
EV46_RS03730	COG0582	viral genome integration into host DNA
EV46_RS03735	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EV46_RS03740	COG2867	negative regulation of translational initiation
EV46_RS03745	COG2914	Belongs to the UPF0125 (RnfH) family
EV46_RS03755	COG0497	DNA recombination
EV46_RS03760	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
EV46_RS03765	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EV46_RS03770	COG1914	H( )-stimulated, divalent metal cation uptake system
EV46_RS03775	COG1942	4-Oxalocrotonate Tautomerase
EV46_RS03780	COG0477	Major facilitator Superfamily
EV46_RS03790	COG0494	nUDIX hydrolase
EV46_RS03820	COG1609	Transcriptional regulator
EV46_RS03825	COG1126	abc transporter atp-binding protein
EV46_RS03830	COG0765	amino acid transport
EV46_RS03840	COG3711	transcriptional antiterminator
EV46_RS03845	COG2723	6-phospho-beta-galactosidase activity
EV46_RS03850	COG1263	PTS System
EV46_RS03850	COG2190	(PTS) system
EV46_RS03850	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EV46_RS03860	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EV46_RS03865	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
EV46_RS03870	COG0698	ribose 5-phosphate isomerase
EV46_RS03885	COG2376	Dihydroxyacetone kinase
EV46_RS03890	COG0149	triose-phosphate isomerase activity
EV46_RS03895	COG1082	Xylose isomerase domain protein TIM barrel
EV46_RS03900	COG2084	Dehydrogenase
EV46_RS03915	COG0814	amino acid
EV46_RS03920	COG1671	Belongs to the UPF0178 family
EV46_RS03925	COG0408	coproporphyrinogen oxidase activity
EV46_RS03930	COG0456	acetyltransferase
EV46_RS03940	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
EV46_RS03950	COG0612	Peptidase, M16
EV46_RS03955	COG4178	(ABC) transporter
EV46_RS03965	COG2837	iron assimilation
EV46_RS03970	COG4150	thiosulfate binding
EV46_RS03975	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
EV46_RS03980	COG4208	sulfate ABC transporter
EV46_RS03985	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EV46_RS03990	COG1136	(ABC) transporter
EV46_RS03990	COG0577	efflux transmembrane transporter activity
EV46_RS03995	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EV46_RS04000	COG0745	RESPONSE REGULATOR receiver
EV46_RS04005	COG2205	protein histidine kinase activity
EV46_RS04010	COG2190	(PTS) system
EV46_RS04020	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EV46_RS04030	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
EV46_RS04035	COG3115	cell septum assembly
EV46_RS04040	COG0531	amino acid
EV46_RS04050	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EV46_RS04060	COG0446	pyridine nucleotide-disulphide oxidoreductase
EV46_RS04065	COG0426	domain, Protein
EV46_RS04065	COG1773	rubredoxin
EV46_RS04070	COG3604	Transcriptional regulator
EV46_RS04075	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
EV46_RS04075	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
EV46_RS04080	COG0583	DNA-binding transcription factor activity
EV46_RS04095	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EV46_RS04095	COG2169	Transcriptional regulator
EV46_RS04100	COG3145	DNA-N1-methyladenine dioxygenase activity
EV46_RS04110	COG3976	FMN-binding domain protein
EV46_RS04110	COG1053	succinate dehydrogenase
EV46_RS04110	COG0431	NADPH-dependent FMN reductase
EV46_RS04115	COG0477	Major facilitator Superfamily
EV46_RS04120	COG3301	Polysulphide reductase, NrfD
EV46_RS04125	COG0437	4 iron, 4 sulfur cluster binding
EV46_RS04135	COG0583	DNA-binding transcription factor activity
EV46_RS04140	COG4948	Mandelate Racemase Muconate Lactonizing
EV46_RS04145	COG1063	alcohol dehydrogenase
EV46_RS04150	COG0477	Major facilitator Superfamily
EV46_RS04155	COG0246	Mannitol dehydrogenase
EV46_RS04160	COG1802	Transcriptional regulator
EV46_RS04165	COG0583	DNA-binding transcription factor activity
EV46_RS04185	COG0811	peptide transport
EV46_RS04205	COG2814	Major facilitator Superfamily
EV46_RS04225	COG0454	-acetyltransferase
EV46_RS04230	COG4773	Receptor
EV46_RS04235	COG4948	Mandelate Racemase Muconate Lactonizing
EV46_RS04260	COG3121	Chaperone
EV46_RS04305	COG1309	transcriptional regulator
EV46_RS04310	COG2249	NAD(P)H dehydrogenase (quinone) activity
EV46_RS04370	COG3423	Transcriptional regulator
EV46_RS04420	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EV46_RS04430	COG0629	single-stranded DNA binding
EV46_RS04480	COG0741	lytic transglycosylase activity
EV46_RS04715	COG2003	Belongs to the UPF0758 family
EV46_RS04760	COG0604	alcohol dehydrogenase
EV46_RS04805	COG0318	PFAM AMP-dependent synthetase and ligase
EV46_RS04810	COG0583	DNA-binding transcription factor activity
EV46_RS04840	COG1982	Orn Lys Arg decarboxylase major
EV46_RS04855	COG5441	Belongs to the UPF0261 family
EV46_RS04860	COG5564	TIM-barrel signal transduction protein
EV46_RS04870	COG1917	Cupin 2, conserved barrel domain protein
EV46_RS04870	COG2169	Transcriptional regulator
EV46_RS04875	COG0741	lytic transglycosylase activity
EV46_RS04880	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
EV46_RS04890	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EV46_RS04895	COG3171	Protein conserved in bacteria
EV46_RS04910	COG0667	Aldo Keto reductase
EV46_RS04920	COG0861	Integral membrane protein TerC family
EV46_RS04925	COG3066	DNA modification
EV46_RS04930	COG0494	nUDIX hydrolase
EV46_RS04940	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EV46_RS04945	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
EV46_RS04955	COG4795	General secretion pathway protein
EV46_RS04970	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
EV46_RS04975	COG1025	Belongs to the peptidase M16 family
EV46_RS04980	COG1074	ATP-dependent DNA helicase activity
EV46_RS04985	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EV46_RS04990	COG1609	Transcriptional regulator
EV46_RS05000	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
EV46_RS05000	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EV46_RS05005	COG0860	N-Acetylmuramoyl-L-alanine amidase
EV46_RS05025	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
EV46_RS05030	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EV46_RS05040	COG1473	amidohydrolase
EV46_RS05045	COG4172	Belongs to the ABC transporter superfamily
EV46_RS05050	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EV46_RS05060	COG0747	negative chemotaxis
EV46_RS05070	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EV46_RS05075	COG2166	iron-sulfur cluster assembly
EV46_RS05080	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EV46_RS05090	COG0583	DNA-binding transcription factor activity
EV46_RS05095	COG2363	Small membrane protein
EV46_RS05100	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
EV46_RS05105	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EV46_RS05110	COG1611	Belongs to the LOG family
EV46_RS05115	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EV46_RS05115	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EV46_RS05155	COG2171	N-acyltransferase activity
EV46_RS05160	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
EV46_RS05170	COG0052	Belongs to the universal ribosomal protein uS2 family
EV46_RS05175	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EV46_RS05180	COG0528	UMP kinase activity
EV46_RS05185	COG0233	cytoplasmic translational termination
EV46_RS05190	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
EV46_RS05195	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
EV46_RS05200	COG0575	Belongs to the CDS family
EV46_RS05205	COG0750	zinc metalloprotease
EV46_RS05210	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EV46_RS05215	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
EV46_RS05220	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EV46_RS05225	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EV46_RS05230	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EV46_RS05235	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EV46_RS05240	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EV46_RS05245	COG0587	DNA-directed DNA polymerase activity
EV46_RS05250	COG0825	malonyl-CoA metabolic process
EV46_RS05255	COG0346	lactoylglutathione lyase activity
EV46_RS05260	COG0037	tRNA processing
EV46_RS05265	COG4568	rho-dependent transcription termination
EV46_RS05280	COG3015	lipoprotein NlpE involved in copper resistance
EV46_RS05285	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EV46_RS05305	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
EV46_RS05320	COG1120	ATPase activity
EV46_RS05325	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EV46_RS05330	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EV46_RS05335	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
EV46_RS05340	COG4772	TonB-dependent receptor
EV46_RS05345	COG3712	iron ion homeostasis
EV46_RS05350	COG1595	DNA-templated transcription, initiation
EV46_RS05355	COG4943	cyclic-guanylate-specific phosphodiesterase activity
EV46_RS05360	COG2824	Alkylphosphonate utilization operon protein PhnA
EV46_RS05365	COG2951	lytic endotransglycosylase activity
EV46_RS05375	COG0583	DNA-binding transcription factor activity
EV46_RS05405	COG2186	Transcriptional regulator
EV46_RS05410	COG1312	Catalyzes the dehydration of D-mannonate
EV46_RS05415	COG5297	Belongs to the glycosyl hydrolase family 6
EV46_RS05420	COG5434	Belongs to the glycosyl hydrolase 28 family
EV46_RS05430	COG1132	(ABC) transporter
EV46_RS05445	COG4615	Cyclic peptide transporter
EV46_RS05455	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EV46_RS05460	COG3123	guanosine phosphorylase activity
EV46_RS05470	COG2974	May be involved in recombination
EV46_RS05475	COG1940	carbohydrate kinase activity
EV46_RS05480	COG0419	ATPase involved in DNA repair
EV46_RS05485	COG0420	3'-5' exonuclease activity
EV46_RS05505	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EV46_RS05515	COG1113	amino acid transport
EV46_RS05520	COG0668	transmembrane transport
EV46_RS05525	COG0450	alkyl hydroperoxide reductase
EV46_RS05530	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
EV46_RS05535	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
EV46_RS05540	COG0343	queuine tRNA-ribosyltransferase activity
EV46_RS05545	COG1862	Preprotein translocase
EV46_RS05550	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EV46_RS05555	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EV46_RS05560	COG4238	major outer membrane lipoprotein
EV46_RS05565	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EV46_RS05570	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EV46_RS05570	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EV46_RS05575	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
EV46_RS05580	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EV46_RS05585	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
EV46_RS05590	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
EV46_RS05595	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EV46_RS05600	COG0142	geranyltranstransferase activity
EV46_RS05605	COG1722	exodeoxyribonuclease VII activity
EV46_RS05610	COG0301	tRNA thio-modification
EV46_RS05610	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EV46_RS05615	COG0693	protein deglycase activity
EV46_RS05620	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EV46_RS05625	COG1666	GTP binding
EV46_RS05630	COG2814	Major facilitator Superfamily
EV46_RS05635	COG0109	protoheme IX farnesyltransferase activity
EV46_RS05640	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
EV46_RS05645	COG1845	cytochrome c oxidase, subunit III
EV46_RS05650	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EV46_RS05655	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
EV46_RS05660	COG2223	nitrite transmembrane transporter activity
EV46_RS05665	COG3056	Lipoprotein
EV46_RS05670	COG0271	Belongs to the BolA IbaG family
EV46_RS05675	COG0544	peptidyl-prolyl cis-trans isomerase activity
EV46_RS05680	COG0740	serine-type endopeptidase activity
EV46_RS05685	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
EV46_RS05690	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EV46_RS05695	COG0776	regulation of translation
EV46_RS05700	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EV46_RS05705	COG1555	photosystem II stabilization
EV46_RS05710	COG0824	Thioesterase
EV46_RS05715	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
EV46_RS05720	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EV46_RS05725	COG1522	sequence-specific DNA binding
EV46_RS05730	COG1132	(ABC) transporter
EV46_RS05735	COG1132	(ABC) transporter
EV46_RS05740	COG0347	Belongs to the P(II) protein family
EV46_RS05745	COG0004	ammonium transporteR
EV46_RS05750	COG1946	Acyl-CoA thioesterase
EV46_RS05755	COG3126	Type III secretion system lipoprotein chaperone (YscW)
EV46_RS05760	COG3695	enzyme binding
EV46_RS05775	COG0254	rRNA binding
EV46_RS05780	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EV46_RS05785	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EV46_RS05790	COG1309	transcriptional regulator
EV46_RS05800	COG2832	Protein of unknown function (DUF454)
EV46_RS05805	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EV46_RS05810	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EV46_RS05815	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
EV46_RS05820	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EV46_RS05825	COG0326	Molecular chaperone. Has ATPase activity
EV46_RS05830	COG0563	adenylate kinase activity
EV46_RS05835	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EV46_RS05840	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EV46_RS05840	COG4651	solute:proton antiporter activity
EV46_RS05845	COG0737	Belongs to the 5'-nucleotidase family
EV46_RS05860	COG1966	Carbon starvation protein
EV46_RS05865	COG2879	small protein
EV46_RS05870	COG0523	cobalamin synthesis protein
EV46_RS05875	COG5434	Belongs to the glycosyl hydrolase 28 family
EV46_RS05885	COG3735	TraB family
EV46_RS05890	COG2217	Heavy metal translocating P-type atpase
EV46_RS05900	COG1585	Membrane protein implicated in regulation of membrane protease activity
EV46_RS05905	COG0330	HflC and HflK could
EV46_RS05910	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EV46_RS05915	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EV46_RS05920	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EV46_RS05925	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EV46_RS05935	COG0784	Response regulator, receiver
EV46_RS05935	COG2205	protein histidine kinase activity
EV46_RS05940	COG2197	response regulator
EV46_RS05945	COG2198	Histidine kinase
EV46_RS05945	COG0642	Histidine kinase
EV46_RS05950	COG2223	nitrite transmembrane transporter activity
EV46_RS05955	COG1733	regulation of RNA biosynthetic process
EV46_RS05960	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
EV46_RS05965	COG1028	Short-chain dehydrogenase reductase Sdr
EV46_RS05970	COG1028	Short-chain dehydrogenase reductase Sdr
EV46_RS05975	COG1169	isochorismate synthase
EV46_RS05980	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
EV46_RS05985	COG0596	Alpha beta hydrolase
EV46_RS05990	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
EV46_RS05995	COG1441	menaquinone biosynthetic process
EV46_RS06015	COG0814	amino acid
EV46_RS06025	COG3118	belongs to the thioredoxin family
EV46_RS06030	COG0300	oxidoreductase activity
EV46_RS06035	COG2755	lipolytic protein G-D-S-L family
EV46_RS06040	COG4181	ATPase activity
EV46_RS06045	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
EV46_RS06050	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
EV46_RS06055	COG0437	4 iron, 4 sulfur cluster binding
EV46_RS06060	COG5557	Pfam Polysulphide reductase, NrfD
EV46_RS06065	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
EV46_RS06070	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
EV46_RS06075	COG1773	rubredoxin
EV46_RS06080	COG0309	Hydrogenase expression formation protein (HypE)
EV46_RS06085	COG0409	Hydrogenase expression formation protein
EV46_RS06090	COG0298	carbon dioxide binding
EV46_RS06095	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
EV46_RS06100	COG0375	protein maturation
EV46_RS06105	COG3604	Transcriptional regulator
EV46_RS06110	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
EV46_RS06120	COG3260	NADH ubiquinone oxidoreductase 20
EV46_RS06125	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EV46_RS06130	COG3261	NADH dehydrogenase
EV46_RS06130	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
EV46_RS06135	COG0651	ATP synthesis coupled electron transport
EV46_RS06140	COG4237	Hydrogenase 4 membrane
EV46_RS06145	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EV46_RS06150	COG0650	Formate hydrogenlyase subunit 4
EV46_RS06155	COG0651	ATP synthesis coupled electron transport
EV46_RS06160	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
EV46_RS06165	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
EV46_RS06170	COG3383	formate dehydrogenase (NAD+) activity
EV46_RS06175	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
EV46_RS06180	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
EV46_RS06185	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EV46_RS06190	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EV46_RS06195	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
EV46_RS06200	COG2233	PERMEase
EV46_RS06205	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EV46_RS06210	COG1393	Belongs to the ArsC family
EV46_RS06215	COG4783	chaperone-mediated protein folding
EV46_RS06220	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EV46_RS06225	COG2716	regulation of RNA biosynthetic process
EV46_RS06235	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
EV46_RS06240	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EV46_RS06245	COG2707	UPF0756 membrane protein
EV46_RS06250	COG1444	tRNA N-acetyltransferase activity
EV46_RS06255	COG3118	belongs to the thioredoxin family
EV46_RS06260	COG0312	modulator of DNA gyrase
EV46_RS06265	COG0312	modulator of DNA gyrase
EV46_RS06280	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
EV46_RS06285	COG3712	iron ion homeostasis
EV46_RS06290	COG1595	DNA-templated transcription, initiation
EV46_RS06300	COG4774	siderophore transport
EV46_RS06305	COG4178	(ABC) transporter
EV46_RS06320	COG3813	Protein conserved in bacteria
EV46_RS06325	COG0400	carboxylic ester hydrolase activity
EV46_RS06335	COG0183	Belongs to the thiolase family
EV46_RS06340	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
EV46_RS06345	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
EV46_RS06360	COG2851	Citrate transporter
EV46_RS06365	COG0583	DNA-binding transcription factor activity
EV46_RS06375	COG1876	peptidase activity
EV46_RS06380	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EV46_RS06385	COG1393	Belongs to the ArsC family
EV46_RS06390	COG1794	racemase activity, acting on amino acids and derivatives
EV46_RS06400	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EV46_RS06405	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EV46_RS06410	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EV46_RS06415	COG0321	lipoyl(octanoyl) transferase activity
EV46_RS06420	COG2921	Belongs to the UPF0250 family
EV46_RS06425	COG1686	Belongs to the peptidase S11 family
EV46_RS06430	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
EV46_RS06435	COG0772	Belongs to the SEDS family
EV46_RS06440	COG0768	penicillin binding
EV46_RS06445	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EV46_RS06450	COG0799	negative regulation of ribosome biogenesis
EV46_RS06455	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EV46_RS06460	COG1466	dna polymerase III delta subunit
EV46_RS06465	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
EV46_RS06470	COG0495	leucyl-tRNA aminoacylation
EV46_RS06475	COG2888	peptidyl-tyrosine sulfation
EV46_RS06480	COG1126	abc transporter atp-binding protein
EV46_RS06485	COG0765	amino acid transport
EV46_RS06490	COG0765	amino acid transport
EV46_RS06500	COG0815	Transfers the fatty acyl group on membrane lipoproteins
EV46_RS06510	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EV46_RS06515	COG1702	phosphate starvation-inducible protein PhoH
EV46_RS06520	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EV46_RS06525	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EV46_RS06570	COG0367	asparagine synthase
EV46_RS06575	COG1846	Transcriptional regulator
EV46_RS06575	COG1940	carbohydrate kinase activity
EV46_RS06580	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EV46_RS06585	COG0363	glucosamine-6-phosphate deaminase activity
EV46_RS06590	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EV46_RS06590	COG2190	(PTS) system
EV46_RS06590	COG1263	PTS System
EV46_RS06595	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EV46_RS06600	COG0735	belongs to the Fur family
EV46_RS06610	COG0840	transmembrane signaling receptor activity
EV46_RS06620	COG0596	Alpha beta hydrolase
EV46_RS06625	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
EV46_RS06630	COG0033	Phosphoglucomutase
EV46_RS06640	COG0745	RESPONSE REGULATOR receiver
EV46_RS06645	COG2205	protein histidine kinase activity
EV46_RS06650	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
EV46_RS06660	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
EV46_RS06680	COG1840	ABC-type Fe3 transport system, periplasmic component
EV46_RS06685	COG3842	ATPase activity
EV46_RS06690	COG3272	Protein of unknown function (DUF1722)
EV46_RS06695	COG0415	Belongs to the DNA photolyase family
EV46_RS06700	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EV46_RS06705	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
EV46_RS06710	COG1984	allophanate hydrolase subunit 2
EV46_RS06715	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
EV46_RS06720	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
EV46_RS06725	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
EV46_RS06740	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
EV46_RS06745	COG1053	succinate dehydrogenase
EV46_RS06750	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EV46_RS06755	COG0567	Dehydrogenase, E1 component
EV46_RS06760	COG0508	dehydrogenase complex catalyzes the overall conversion of
EV46_RS06765	COG0045	succinate-CoA ligase (ADP-forming) activity
EV46_RS06770	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
EV46_RS06775	COG1271	oxidase subunit
EV46_RS06780	COG1294	oxidase, subunit
EV46_RS06785	COG3790	cyd operon protein YbgE
EV46_RS06790	COG0824	Thioesterase
EV46_RS06795	COG0811	peptide transport
EV46_RS06800	COG0848	biopolymer transport protein
EV46_RS06805	COG3064	Membrane
EV46_RS06810	COG0823	Involved in the tonB-independent uptake of proteins
EV46_RS06815	COG2885	chlorophyll binding
EV46_RS06820	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
EV46_RS06835	COG1811	Na channel or pump
EV46_RS06845	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
EV46_RS06855	COG1230	cation diffusion facilitator family transporter
EV46_RS06860	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EV46_RS06865	COG0588	phosphoglycerate mutase activity
EV46_RS06870	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EV46_RS06875	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EV46_RS06895	COG2017	converts alpha-aldose to the beta-anomer
EV46_RS06900	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EV46_RS06905	COG1119	ATPase activity
EV46_RS06910	COG3585	molybdate ion transport
EV46_RS06910	COG2005	Transcriptional regulator
EV46_RS06920	COG0725	ABC transporter, periplasmic molybdate-binding protein
EV46_RS06925	COG4149	molybdate abc transporter
EV46_RS06930	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
EV46_RS06940	COG1609	Transcriptional regulator
EV46_RS06955	COG2211	Major facilitator Superfamily
EV46_RS06960	COG0837	glucose binding
EV46_RS06965	COG0561	phosphatase activity
EV46_RS06975	COG2706	6-phosphogluconolactonase activity
EV46_RS06990	COG2864	formate dehydrogenase
EV46_RS06995	COG0437	4 iron, 4 sulfur cluster binding
EV46_RS07000	COG0243	molybdopterin cofactor binding
EV46_RS07000	COG3383	formate dehydrogenase (NAD+) activity
EV46_RS07005	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EV46_RS07005	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EV46_RS07010	COG0489	protein tyrosine kinase activity
EV46_RS07015	COG0572	uridine kinase
EV46_RS07020	COG0717	Belongs to the dCTP deaminase family
EV46_RS07025	COG2982	Protein involved in outer membrane biogenesis
EV46_RS07030	COG3069	C4-dicarboxylate transmembrane transporter activity
EV46_RS07035	COG1253	flavin adenine dinucleotide binding
EV46_RS07040	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EV46_RS07055	COG3206	protein involved in exopolysaccharide biosynthesis
EV46_RS07055	COG0489	protein tyrosine kinase activity
EV46_RS07070	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
EV46_RS07090	COG0028	Belongs to the TPP enzyme family
EV46_RS07100	COG4569	acetaldehyde dehydrogenase (acetylating) activity
EV46_RS07105	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EV46_RS07115	COG2244	polysaccharide biosynthetic process
EV46_RS07200	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EV46_RS07205	COG1605	Chorismate mutase
EV46_RS07215	COG2723	6-phospho-beta-galactosidase activity
EV46_RS07220	COG3711	transcriptional antiterminator
EV46_RS07225	COG3706	GGDEF domain
EV46_RS07245	COG3962	Belongs to the TPP enzyme family
EV46_RS07250	COG0673	inositol 2-dehydrogenase activity
EV46_RS07265	COG1172	Belongs to the binding-protein-dependent transport system permease family
EV46_RS07285	COG3718	enzyme involved in inositol metabolism
EV46_RS07290	COG3842	ATPase activity
EV46_RS07295	COG4208	sulfate ABC transporter
EV46_RS07300	COG1840	ABC-type Fe3 transport system, periplasmic component
EV46_RS07315	COG3615	Tellurite resistance protein tehB
EV46_RS07335	COG2207	Transcriptional regulator
EV46_RS07340	COG0583	DNA-binding transcription factor activity
EV46_RS07345	COG0604	alcohol dehydrogenase
EV46_RS07355	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EV46_RS07415	COG2223	nitrite transmembrane transporter activity
EV46_RS07420	COG3250	beta-galactosidase activity
EV46_RS07425	COG1609	Transcriptional regulator
EV46_RS07430	COG3842	ATPase activity
EV46_RS07440	COG1840	ABC-type Fe3 transport system, periplasmic component
EV46_RS07445	COG2271	Major facilitator Superfamily
EV46_RS07460	COG1464	Belongs to the NlpA lipoprotein family
EV46_RS07475	COG0583	DNA-binding transcription factor activity
EV46_RS07480	COG1301	dicarboxylic acid transport
EV46_RS07490	COG2851	Citrate transporter
EV46_RS07495	COG3383	formate dehydrogenase (NAD+) activity
EV46_RS07500	COG0840	transmembrane signaling receptor activity
EV46_RS07505	COG0672	)-iron permease
EV46_RS07520	COG1136	(ABC) transporter
EV46_RS07520	COG0577	efflux transmembrane transporter activity
EV46_RS07530	COG0577	efflux transmembrane transporter activity
EV46_RS07530	COG1136	(ABC) transporter
EV46_RS07535	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EV46_RS07540	COG0697	spore germination
EV46_RS07555	COG1301	dicarboxylic acid transport
EV46_RS07570	COG0371	Dehydrogenase
EV46_RS07575	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EV46_RS07580	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
EV46_RS07590	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
EV46_RS07600	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EV46_RS07605	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
EV46_RS07610	COG2515	1-aminocyclopropane-1-carboxylate deaminase
EV46_RS07620	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
EV46_RS07660	COG1012	belongs to the aldehyde dehydrogenase family
EV46_RS07665	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EV46_RS07680	COG0477	Major facilitator Superfamily
EV46_RS07685	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EV46_RS07690	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EV46_RS07695	COG0747	negative chemotaxis
EV46_RS07710	COG0444	Belongs to the ABC transporter superfamily
EV46_RS07730	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EV46_RS07765	COG3008	intermembrane lipid transfer
EV46_RS07765	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EV46_RS07770	COG2995	paraquat-inducible protein a
EV46_RS07785	COG0835	chemotaxis
EV46_RS07785	COG0784	Response regulator, receiver
EV46_RS07790	COG0625	glutathione transferase activity
EV46_RS07795	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EV46_RS07800	COG0640	Transcriptional regulator
EV46_RS07805	COG2814	Major facilitator Superfamily
EV46_RS07810	COG2814	Major facilitator Superfamily
EV46_RS07815	COG0789	Transcriptional regulator
EV46_RS07815	COG4978	Transcriptional regulator
EV46_RS07825	COG3122	Protein conserved in bacteria
EV46_RS07845	COG3423	Transcriptional regulator
EV46_RS07860	COG0582	viral genome integration into host DNA
EV46_RS07870	COG3228	Belongs to the MtfA family
EV46_RS07890	COG0840	transmembrane signaling receptor activity
EV46_RS07895	COG0697	spore germination
EV46_RS07920	COG0643	Histidine kinase
EV46_RS07920	COG2198	Histidine kinase
EV46_RS07925	COG0835	chemotaxis
EV46_RS07930	COG0840	transmembrane signaling receptor activity
EV46_RS07935	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EV46_RS07940	COG2201	protein-glutamate methylesterase activity
EV46_RS07945	COG0745	RESPONSE REGULATOR receiver
EV46_RS07955	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EV46_RS07960	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EV46_RS07975	COG2747	anti-sigma28 factor FlgM
EV46_RS07985	COG1815	bacterial-type flagellum-dependent cell motility
EV46_RS07990	COG1558	bacterial-type flagellum-dependent cell motility
EV46_RS07995	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
EV46_RS08000	COG1749	Flagellar hook protein flgE
EV46_RS08005	COG4787	bacterial-type flagellum-dependent cell motility
EV46_RS08015	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
EV46_RS08020	COG1706	bacterial-type flagellum-dependent cell motility
EV46_RS08070	COG1580	Controls the rotational direction of flagella during chemotaxis
EV46_RS08090	COG1317	bacterial-type flagellum organization
EV46_RS08105	COG1677	Flagellar hook-basal body complex protein FliE
EV46_RS08130	COG0500	methyltransferase
EV46_RS08165	COG1191	sigma factor activity
EV46_RS08175	COG1702	phosphate starvation-inducible protein PhoH
EV46_RS08190	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EV46_RS08195	COG1309	transcriptional regulator
EV46_RS08200	COG1012	belongs to the aldehyde dehydrogenase family
EV46_RS08205	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
EV46_RS08210	COG2979	Protein of unknown function (DUF533)
EV46_RS08215	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EV46_RS08220	COG1067	ATP-dependent peptidase activity
EV46_RS08235	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
EV46_RS08240	COG3070	regulator of competence-specific genes
EV46_RS08245	COG1289	transmembrane transporter activity
EV46_RS08250	COG3304	Inner membrane component domain
EV46_RS08255	COG0210	DNA helicase
EV46_RS08260	COG1803	Methylglyoxal synthase
EV46_RS08265	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
EV46_RS08270	COG1832	CoA-binding protein
EV46_RS08275	COG3785	DNA binding
EV46_RS08280	COG1254	Belongs to the acylphosphatase family
EV46_RS08285	COG2920	part of a sulfur-relay system
EV46_RS08290	COG0670	Belongs to the BI1 family
EV46_RS08320	COG0589	response to stress
EV46_RS08325	COG1683	Conserved Protein
EV46_RS08360	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
EV46_RS08365	COG2943	transferase activity, transferring hexosyl groups
EV46_RS08370	COG1560	Kdo2-lipid A biosynthetic process
EV46_RS08375	COG1902	pentaerythritol trinitrate reductase activity
EV46_RS08380	COG1054	Belongs to the UPF0176 family
EV46_RS08385	COG2353	YceI-like domain
EV46_RS08390	COG3038	cytochrome b561
EV46_RS08410	COG0418	dihydroorotase activity
EV46_RS08420	COG1530	ribonuclease E activity
EV46_RS08425	COG0564	pseudouridine synthase activity
EV46_RS08430	COG0424	maF-like protein
EV46_RS08435	COG1399	metal-binding, possibly nucleic acid-binding protein
EV46_RS08440	COG0333	Belongs to the bacterial ribosomal protein bL32 family
EV46_RS08445	COG0416	fatty acid biosynthetic process
EV46_RS08450	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EV46_RS08455	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
EV46_RS08465	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EV46_RS08470	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EV46_RS08475	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EV46_RS08480	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EV46_RS08485	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EV46_RS08490	COG0470	DNA polymerase III
EV46_RS08495	COG0084	hydrolase, TatD family'
EV46_RS08500	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EV46_RS08500	COG1263	PTS System
EV46_RS08510	COG0477	Major facilitator Superfamily
EV46_RS08515	COG0537	adenosine 5'-monophosphoramidase activity
EV46_RS08525	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
EV46_RS08535	COG1472	Belongs to the glycosyl hydrolase 3 family
EV46_RS08540	COG3150	esterase
EV46_RS08545	COG1252	NADH dehydrogenase
EV46_RS08550	COG3134	Outer membrane lipoprotein
EV46_RS08565	COG1309	transcriptional regulator
EV46_RS08570	COG0443	Heat shock 70 kDa protein
EV46_RS08575	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EV46_RS08580	COG4591	ABC-type transport system involved in lipoprotein release permease component
EV46_RS08585	COG1136	(ABC) transporter
EV46_RS08590	COG4591	ABC-type transport system involved in lipoprotein release permease component
EV46_RS08595	COG1940	carbohydrate kinase activity
EV46_RS08615	COG2226	methyltransferase
EV46_RS08620	COG4139	cobalamin transport
EV46_RS08625	COG0386	Belongs to the glutathione peroxidase family
EV46_RS08630	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
EV46_RS08635	COG0791	NLP P60 protein
EV46_RS08640	COG0129	dihydroxy-acid dehydratase activity
EV46_RS08645	COG1609	Transcriptional regulator
EV46_RS08650	COG3265	gluconokinase activity
EV46_RS08655	COG2610	gluconate transmembrane transporter activity
EV46_RS08665	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
EV46_RS08670	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
EV46_RS08675	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EV46_RS08680	COG4558	Periplasmic binding protein
EV46_RS08685	COG3720	iron ion transport
EV46_RS08700	COG2188	Transcriptional regulator
EV46_RS08705	COG0366	Alpha amylase catalytic
EV46_RS08710	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EV46_RS08715	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
EV46_RS08720	COG0574	Belongs to the PEP-utilizing enzyme family
EV46_RS08720	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EV46_RS08725	COG1477	protein flavinylation
EV46_RS08730	COG0628	permease
EV46_RS08735	COG0277	FAD linked oxidase domain protein
EV46_RS08735	COG0247	lactate metabolic process
EV46_RS08740	COG2050	protein possibly involved in aromatic compounds catabolism
EV46_RS08750	COG0316	Belongs to the HesB IscA family
EV46_RS08755	COG0719	Fe-S assembly protein
EV46_RS08760	COG0396	ATPase activity
EV46_RS08765	COG0719	Fe-S assembly protein
EV46_RS08770	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EV46_RS08775	COG2166	iron-sulfur cluster assembly
EV46_RS08780	COG1388	LysM domain
EV46_RS08780	COG1376	ErfK ybiS ycfS ynhG family protein
EV46_RS08785	COG4238	major outer membrane lipoprotein
EV46_RS08815	COG2382	esterase
EV46_RS08825	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
EV46_RS08830	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
EV46_RS08835	COG0437	4 iron, 4 sulfur cluster binding
EV46_RS08840	COG3301	Polysulphide reductase, NrfD
EV46_RS08845	COG1138	Cytochrome C-type biogenesis protein
EV46_RS08850	COG3088	subunit of a heme lyase
EV46_RS08855	COG4235	cytochrome complex assembly
EV46_RS08860	COG4133	protoheme IX ABC transporter activity
EV46_RS08865	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EV46_RS08870	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EV46_RS08875	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EV46_RS08880	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
EV46_RS08885	COG1138	Cytochrome C-type biogenesis protein
EV46_RS08890	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EV46_RS08895	COG4235	cytochrome complex assembly
EV46_RS08895	COG3088	subunit of a heme lyase
EV46_RS08900	COG3088	subunit of a heme lyase
EV46_RS08900	COG4235	cytochrome complex assembly
EV46_RS08905	COG3005	denitrification pathway
EV46_RS08910	COG3043	anaerobic respiration
EV46_RS08915	COG0348	domain, Protein
EV46_RS08920	COG0437	4 iron, 4 sulfur cluster binding
EV46_RS08925	COG0243	molybdopterin cofactor binding
EV46_RS08930	COG3062	negative regulation of establishment of protein localization
EV46_RS08935	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
EV46_RS08935	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EV46_RS08940	COG3850	Histidine kinase
EV46_RS08945	COG2197	response regulator
EV46_RS08955	COG0477	Major facilitator Superfamily
EV46_RS08965	COG4221	oxidoreductase activity
EV46_RS08975	COG0561	phosphatase activity
EV46_RS08985	COG1408	metallophosphoesterase
EV46_RS08990	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
EV46_RS09015	COG1116	anion transmembrane transporter activity
EV46_RS09020	COG3665	Urea carboxylase-associated protein
EV46_RS09035	COG1556	Lactate utilization protein
EV46_RS09040	COG1139	Iron-sulfur cluster binding protein
EV46_RS09045	COG0247	lactate metabolic process
EV46_RS09050	COG1620	l-lactate permease
EV46_RS09060	COG0534	Mate efflux family protein
EV46_RS09065	COG0307	riboflavin synthase, alpha
EV46_RS09070	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EV46_RS09075	COG1609	Transcriptional regulator
EV46_RS09080	COG0791	NLP P60 protein
EV46_RS09085	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
EV46_RS09090	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EV46_RS09095	COG0346	lactoylglutathione lyase activity
EV46_RS09100	COG1846	Transcriptional regulator
EV46_RS09110	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
EV46_RS09115	COG3895	Periplasmic Protein
EV46_RS09120	COG0259	pyridoxamine-phosphate oxidase activity
EV46_RS09125	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EV46_RS09130	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
EV46_RS09135	COG0625	glutathione transferase activity
EV46_RS09140	COG1301	dicarboxylic acid transport
EV46_RS09145	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
EV46_RS09155	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EV46_RS09160	COG0671	phosphoesterase, PA-phosphatase related
EV46_RS09175	COG1129	ABC transporter
EV46_RS09180	COG1172	Belongs to the binding-protein-dependent transport system permease family
EV46_RS09185	COG3959	Transketolase, thiamine diphosphate binding domain
EV46_RS09190	COG3958	Transketolase
EV46_RS09195	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EV46_RS09200	COG1082	Xylose isomerase domain protein TIM barrel
EV46_RS09210	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
EV46_RS09215	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
EV46_RS09220	COG0284	orotidine-5'-phosphate decarboxylase activity
EV46_RS09225	COG0023	Translation Initiation Factor
EV46_RS09240	COG1966	Carbon starvation protein
EV46_RS09245	COG4989	oxidoreductase activity
EV46_RS09250	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
EV46_RS09260	COG0583	DNA-binding transcription factor activity
EV46_RS09265	COG1609	Transcriptional regulator
EV46_RS09270	COG2271	Major facilitator Superfamily
EV46_RS09280	COG1053	succinate dehydrogenase
EV46_RS09310	COG4171	peptide transport system, permease
EV46_RS09320	COG4166	transmembrane transport
EV46_RS09330	COG1028	Short-chain dehydrogenase reductase Sdr
EV46_RS09340	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
EV46_RS09345	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
EV46_RS09350	COG1842	Phage shock protein A
EV46_RS09360	COG1983	PspC domain protein
EV46_RS09365	COG3106	COG3106 Predicted ATPase
EV46_RS09370	COG3768	UPF0283 membrane protein
EV46_RS09385	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
EV46_RS09390	COG2866	Carboxypeptidase
EV46_RS09395	COG4166	transmembrane transport
EV46_RS09400	COG0598	Magnesium transport protein CorA
EV46_RS09405	COG0037	tRNA processing
EV46_RS09430	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EV46_RS09435	COG0840	transmembrane signaling receptor activity
EV46_RS09440	COG0840	transmembrane signaling receptor activity
EV46_RS09445	COG2911	Protein conserved in bacteria
EV46_RS09455	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
EV46_RS09460	COG1643	Atp-dependent helicase
EV46_RS09470	COG3300	MHYT domain
EV46_RS09470	COG5001	Diguanylate cyclase
EV46_RS09475	COG3591	Belongs to the peptidase S1B family
EV46_RS09490	COG2205	protein histidine kinase activity
EV46_RS09495	COG0745	RESPONSE REGULATOR receiver
EV46_RS09525	COG0659	secondary active sulfate transmembrane transporter activity
EV46_RS09530	COG0387	Pfam Sodium calcium exchanger
EV46_RS09540	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
EV46_RS09555	COG2197	response regulator
EV46_RS09560	COG3850	Histidine kinase
EV46_RS09565	COG2223	nitrite transmembrane transporter activity
EV46_RS09570	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
EV46_RS09575	COG1140	nitrate reductase beta subunit
EV46_RS09580	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
EV46_RS09585	COG2181	nitrate reductase activity
EV46_RS09590	COG0697	spore germination
EV46_RS09595	COG1846	Transcriptional regulator
EV46_RS09635	COG2261	transglycosylase associated protein
EV46_RS09665	COG1280	lysine exporter protein (LysE YggA)
EV46_RS09670	COG3842	ATPase activity
EV46_RS09680	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EV46_RS09685	COG1012	belongs to the aldehyde dehydrogenase family
EV46_RS09695	COG1176	ABC-type spermidine putrescine transport system, permease component I
EV46_RS09705	COG1028	Short-chain dehydrogenase reductase Sdr
EV46_RS09715	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EV46_RS09725	COG0671	phosphoesterase, PA-phosphatase related
EV46_RS09730	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EV46_RS09735	COG2011	ABC-type metal ion transport system permease component
EV46_RS09740	COG4948	Mandelate Racemase Muconate Lactonizing
EV46_RS09745	COG1464	Belongs to the NlpA lipoprotein family
EV46_RS09765	COG2814	Major facilitator Superfamily
EV46_RS09795	COG4792	protein secretion
EV46_RS09805	COG4794	Type iii secretion
EV46_RS09830	COG1157	protein secretion by the type III secretion system
EV46_RS09855	COG3850	Histidine kinase
EV46_RS09860	COG2197	response regulator
EV46_RS09870	COG2200	EAL domain
EV46_RS09885	COG4669	(LipO)protein
EV46_RS09930	COG3501	Rhs element vgr protein
EV46_RS09985	COG1802	Transcriptional regulator
EV46_RS09990	COG2831	hemolysin activation secretion protein
EV46_RS09995	COG3210	domain, Protein
EV46_RS10050	COG1802	Transcriptional regulator
EV46_RS10055	COG0683	leucine binding
EV46_RS10070	COG1129	ABC transporter
EV46_RS10085	COG2314	TM2 domain
EV46_RS10090	COG2226	methyltransferase
EV46_RS10095	COG1126	abc transporter atp-binding protein
EV46_RS10100	COG0765	amino acid transport
EV46_RS10110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EV46_RS10120	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EV46_RS10130	COG1473	amidohydrolase
EV46_RS10135	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EV46_RS10145	COG2234	aminopeptidase activity
EV46_RS10150	COG1609	Transcriptional regulator
EV46_RS10155	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EV46_RS10155	COG1263	PTS System
EV46_RS10160	COG2723	6-phospho-beta-galactosidase activity
EV46_RS10165	COG0483	inositol monophosphate 1-phosphatase activity
EV46_RS10170	COG0346	lactoylglutathione lyase activity
EV46_RS10220	COG0582	viral genome integration into host DNA
EV46_RS10240	COG0582	viral genome integration into host DNA
EV46_RS10245	COG0012	GTP binding
EV46_RS10250	COG0193	aminoacyl-tRNA hydrolase activity
EV46_RS10260	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
EV46_RS10265	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
EV46_RS10270	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
EV46_RS10275	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
EV46_RS10280	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EV46_RS10285	COG2890	protein-(glutamine-N5) methyltransferase activity
EV46_RS10295	COG2912	Transglutaminase-like superfamily
EV46_RS10300	COG2877	3-deoxy-8-phosphooctulonate synthase activity
EV46_RS10310	COG4644	lycopene metabolic process
EV46_RS10330	COG3385	transposase activity
EV46_RS10340	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
EV46_RS10345	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
EV46_RS10355	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EV46_RS10360	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EV46_RS10365	COG0673	inositol 2-dehydrogenase activity
EV46_RS10380	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EV46_RS10395	COG1028	Short-chain dehydrogenase reductase Sdr
EV46_RS10420	COG4305	rare lipoprotein A
EV46_RS10425	COG1764	response to oxidative stress
EV46_RS10430	COG3783	Cytochrome b(562)
EV46_RS10440	COG0738	Major facilitator superfamily
EV46_RS10445	COG0456	acetyltransferase
EV46_RS10470	COG2963	transposase activity
EV46_RS10485	COG1902	pentaerythritol trinitrate reductase activity
EV46_RS10490	COG1073	alpha beta
EV46_RS10500	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EV46_RS10530	COG4628	conserved protein (DUF2132)
EV46_RS10535	COG1649	PFAM Uncharacterised BCR, COG1649
EV46_RS10550	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EV46_RS10555	COG0076	glutamate decarboxylase activity
EV46_RS10560	COG1942	4-Oxalocrotonate Tautomerase
EV46_RS10565	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EV46_RS10580	COG1215	transferase activity, transferring glycosyl groups
EV46_RS10585	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EV46_RS10590	COG4221	oxidoreductase activity
EV46_RS10615	COG0477	Major facilitator Superfamily
EV46_RS10620	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
EV46_RS10625	COG1940	carbohydrate kinase activity
EV46_RS10630	COG0583	DNA-binding transcription factor activity
EV46_RS10635	COG2814	Major facilitator Superfamily
EV46_RS10645	COG0114	fumarate hydratase activity
EV46_RS10650	COG1482	cell wall glycoprotein biosynthetic process
EV46_RS10655	COG5339	Protein conserved in bacteria
EV46_RS10665	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
EV46_RS10675	COG0385	Bile acid
EV46_RS10680	COG0673	inositol 2-dehydrogenase activity
EV46_RS10690	COG1172	Belongs to the binding-protein-dependent transport system permease family
EV46_RS10695	COG1129	ABC transporter
EV46_RS10700	COG1879	ABC-type sugar transport system periplasmic component
EV46_RS10705	COG1069	ribulokinase activity
EV46_RS10710	COG2160	L-arabinose isomerase activity
EV46_RS10715	COG4657	Part of a membrane complex involved in electron transport
EV46_RS10720	COG2878	Part of a membrane complex involved in electron transport
EV46_RS10725	COG4656	Part of a membrane complex involved in electron transport
EV46_RS10730	COG4658	electron transport chain
EV46_RS10735	COG4659	FMN binding
EV46_RS10745	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EV46_RS10750	COG3104	oligopeptide transport
EV46_RS10770	COG0616	signal peptide processing
EV46_RS10775	COG1028	Short-chain dehydrogenase reductase Sdr
EV46_RS10785	COG1187	pseudouridine synthase activity
EV46_RS10790	COG0009	L-threonylcarbamoyladenylate synthase
EV46_RS10795	COG0613	PHP domain protein
EV46_RS10800	COG1215	transferase activity, transferring glycosyl groups
EV46_RS10815	COG0512	Glutamine amidotransferase of anthranilate synthase
EV46_RS10820	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EV46_RS10825	COG0135	phosphoribosylanthranilate isomerase activity
EV46_RS10825	COG0134	indole-3-glycerol-phosphate synthase activity
EV46_RS10830	COG0133	tryptophan synthase activity
EV46_RS10835	COG0159	tryptophan synthase activity
EV46_RS10840	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
EV46_RS10845	COG3047	cAMP biosynthetic process
EV46_RS10875	COG3646	Phage regulatory protein
EV46_RS10895	COG2917	probably involved in intracellular septation
EV46_RS10900	COG1607	acyl-coa hydrolase
EV46_RS10910	COG2350	Protein conserved in bacteria
EV46_RS10920	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EV46_RS10925	COG3099	Belongs to the UPF0263 family
EV46_RS10935	COG0444	Belongs to the ABC transporter superfamily
EV46_RS10940	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EV46_RS10945	COG0601	transmembrane transport
EV46_RS10960	COG1454	alcohol dehydrogenase
EV46_RS10960	COG1012	belongs to the aldehyde dehydrogenase family
EV46_RS10965	COG1435	thymidine kinase activity
EV46_RS10975	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EV46_RS10980	COG0745	RESPONSE REGULATOR receiver
EV46_RS10985	COG1752	Esterase of the alpha-beta hydrolase superfamily
EV46_RS10990	COG0788	formyltetrahydrofolate deformylase activity
EV46_RS11000	COG2860	membrane
EV46_RS11005	COG0708	Exodeoxyribonuclease III
EV46_RS11015	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EV46_RS11020	COG0778	Nitroreductase
EV46_RS11025	COG0616	signal peptide processing
EV46_RS11030	COG0252	asparaginase activity
EV46_RS11035	COG1335	isochorismatase
EV46_RS11040	COG3139	Protein of unknown function (DUF1315)
EV46_RS11045	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EV46_RS11060	COG0656	L-ascorbic acid biosynthetic process
EV46_RS11065	COG3713	MltA-interacting MipA family protein
EV46_RS11070	COG2766	serine protein kinase
EV46_RS11075	COG2718	Belongs to the UPF0229 family
EV46_RS11085	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EV46_RS11090	COG0205	6-phosphofructokinase activity
EV46_RS11110	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EV46_RS11120	COG3684	Belongs to the aldolase LacD family
EV46_RS11125	COG2719	SpoVR family
EV46_RS11130	COG2186	Transcriptional regulator
EV46_RS11135	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EV46_RS11140	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
EV46_RS11155	COG2983	Belongs to the UPF0260 family
EV46_RS11160	COG0179	Fumarylacetoacetate (FAA) hydrolase
EV46_RS11165	COG3100	YcgL domain-containing protein
EV46_RS11170	COG0850	regulation of cytokinetic process
EV46_RS11175	COG2894	cell division
EV46_RS11180	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
EV46_RS11185	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
EV46_RS11190	COG0318	PFAM AMP-dependent synthetase and ligase
EV46_RS11195	COG3065	identical protein binding
EV46_RS11200	COG1214	PFAM Peptidase M22, glycoprotease
EV46_RS11205	COG1199	ATP-dependent helicase activity
EV46_RS11210	COG0251	oxidation-reduction process
EV46_RS11215	COG3140	Belongs to the UPF0181 family
EV46_RS11225	COG0494	nUDIX hydrolase
EV46_RS11230	COG1760	l-serine dehydratase
EV46_RS11235	COG0583	DNA-binding transcription factor activity
EV46_RS11240	COG1250	3-hydroxyacyl-CoA dehydrogenase
EV46_RS11240	COG0824	Thioesterase
EV46_RS11245	COG1335	isochorismatase
EV46_RS11250	COG1253	flavin adenine dinucleotide binding
EV46_RS11255	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
EV46_RS11255	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EV46_RS11260	COG3715	PTS system
EV46_RS11265	COG3716	PTS system mannose fructose sorbose family IID component
EV46_RS11270	COG4811	Protein of unknown function (DUF986)
EV46_RS11275	COG1971	Probably functions as a manganese efflux pump
EV46_RS11280	COG2226	methyltransferase
EV46_RS11290	COG0803	Belongs to the bacterial solute-binding protein 9 family
EV46_RS11295	COG1121	(ABC) transporter
EV46_RS11300	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EV46_RS11305	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EV46_RS11310	COG3001	Fructosamine kinase
EV46_RS11320	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EV46_RS11325	COG1917	Cupin 2, conserved barrel domain protein
EV46_RS11330	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
EV46_RS11335	COG1028	Short-chain dehydrogenase reductase Sdr
EV46_RS11345	COG1175	transmembrane transport
EV46_RS11350	COG0395	ABC-type sugar transport system, permease component
EV46_RS11355	COG3842	ATPase activity
EV46_RS11360	COG1653	transport
EV46_RS11365	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
EV46_RS11370	COG0657	acetylesterase activity
EV46_RS11370	COG2755	lipolytic protein G-D-S-L family
EV46_RS11375	COG1988	membrane-bound metal-dependent
EV46_RS11380	COG1823	symporter activity
EV46_RS11385	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EV46_RS11390	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
EV46_RS11400	COG1132	(ABC) transporter
EV46_RS11410	COG0776	regulation of translation
EV46_RS11415	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EV46_RS11415	COG0072	phenylalanine-tRNA ligase activity
EV46_RS11420	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EV46_RS11425	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EV46_RS11430	COG0291	Belongs to the bacterial ribosomal protein bL35 family
EV46_RS11435	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
EV46_RS11440	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EV46_RS11445	COG1113	amino acid transport
EV46_RS11460	COG0823	Involved in the tonB-independent uptake of proteins
EV46_RS11465	COG0501	Belongs to the peptidase M48B family
EV46_RS11475	COG1653	transport
EV46_RS11480	COG2223	nitrite transmembrane transporter activity
EV46_RS11485	COG3279	Response regulator of the LytR AlgR family
EV46_RS11490	COG3275	phosphorelay sensor kinase activity
EV46_RS11495	COG3300	MHYT domain
EV46_RS11495	COG5001	Diguanylate cyclase
EV46_RS11510	COG0348	domain, Protein
EV46_RS11515	COG0538	isocitrate dehydrogenase activity
EV46_RS11520	COG1187	pseudouridine synthase activity
EV46_RS11530	COG0482	sulfurtransferase activity
EV46_RS11535	COG2915	High frequency lysogenization protein hflD homolog
EV46_RS11540	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EV46_RS11555	COG2850	peptidyl-arginine hydroxylation
EV46_RS11560	COG2195	Cleaves the N-terminal amino acid of tripeptides
EV46_RS11565	COG3842	ATPase activity
EV46_RS11575	COG1177	transmembrane transport
EV46_RS11585	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EV46_RS11590	COG2223	nitrite transmembrane transporter activity
EV46_RS11595	COG1881	PFAM PEBP family protein
EV46_RS11610	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
EV46_RS11615	COG1956	GAF domain-containing protein
EV46_RS11620	COG2995	paraquat-inducible protein a
EV46_RS11625	COG3008	intermembrane lipid transfer
EV46_RS11630	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
EV46_RS11630	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EV46_RS11665	COG1278	Cold shock
EV46_RS11675	COG1528	Iron-storage protein
EV46_RS11685	COG1770	oligopeptidase
EV46_RS11690	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
EV46_RS11695	COG0800	Aldolase
EV46_RS11700	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EV46_RS11705	COG1737	Transcriptional regulator
EV46_RS11710	COG0469	pyruvate kinase activity
EV46_RS11715	COG1560	Kdo2-lipid A biosynthetic process
EV46_RS11720	COG0739	heme binding
EV46_RS11725	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
EV46_RS11730	COG1121	(ABC) transporter
EV46_RS11735	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EV46_RS11740	COG1609	Transcriptional regulator
EV46_RS11745	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EV46_RS11750	COG1447	Phosphotransferase system cellobiose-specific component IIA
EV46_RS11755	COG4580	involved in the transport of maltose and maltodextrins
EV46_RS11760	COG2255	four-way junction helicase activity
EV46_RS11765	COG0632	four-way junction helicase activity
EV46_RS11770	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
EV46_RS11775	COG0217	transcriptional regulatory protein
EV46_RS11780	COG0494	nUDIX hydrolase
EV46_RS11785	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EV46_RS11790	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
EV46_RS11795	COG1801	Protein of unknown function DUF72
EV46_RS11800	COG3788	relative of glutathione S-transferase, MAPEG superfamily
EV46_RS11805	COG2226	methyltransferase
EV46_RS11810	COG0500	methyltransferase
EV46_RS11825	COG3142	Participates in the control of copper homeostasis
EV46_RS11830	COG3102	Protein conserved in bacteria
EV46_RS11835	COG0018	arginyl-trna synthetase
EV46_RS11840	COG0728	peptidoglycan biosynthetic process
EV46_RS11850	COG3132	Protein of unknown function, DUF480
EV46_RS11855	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EV46_RS11860	COG0477	Major facilitator Superfamily
EV46_RS11865	COG2999	glutathione oxidoreductase activity
EV46_RS11875	COG3381	protein complex oligomerization
EV46_RS11880	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
EV46_RS11950	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
EV46_RS11960	COG0840	transmembrane signaling receptor activity
EV46_RS11965	COG3009	Protein conserved in bacteria
EV46_RS11970	COG3008	intermembrane lipid transfer
EV46_RS11970	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EV46_RS11975	COG2995	paraquat-inducible protein a
EV46_RS11980	COG0488	(ABC) transporter
EV46_RS11985	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EV46_RS11985	COG0116	Belongs to the methyltransferase superfamily
EV46_RS11990	COG0633	Ferredoxin
EV46_RS11990	COG3217	Mosc domain protein beta barrel domain protein
EV46_RS12000	COG0167	dihydroorotate dehydrogenase activity
EV46_RS12005	COG0308	aminopeptidase N
EV46_RS12010	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
EV46_RS12015	COG0017	Asparaginyl-tRNA synthetase
EV46_RS12025	COG1448	Aminotransferase
EV46_RS12030	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EV46_RS12035	COG3108	Peptidase M15
EV46_RS12040	COG2989	Protein conserved in bacteria
EV46_RS12045	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
EV46_RS12050	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
EV46_RS12055	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
EV46_RS12060	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EV46_RS12065	COG1434	Gram-negative-bacterium-type cell wall biogenesis
EV46_RS12070	COG3173	Aminoglycoside phosphotransferase
EV46_RS12080	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
EV46_RS12085	COG2835	tetraacyldisaccharide 4'-kinase activity
EV46_RS12090	COG1663	tetraacyldisaccharide 4'-kinase activity
EV46_RS12095	COG1132	(ABC) transporter
EV46_RS12100	COG0658	competence protein
EV46_RS12100	COG2333	competence protein COMEC
EV46_RS12105	COG2926	Belongs to the UPF0265 family
EV46_RS12110	COG4604	ABC transporter, ATP-binding protein
EV46_RS12115	COG4605	iron ion homeostasis
EV46_RS12125	COG4607	ABC-type enterochelin transport system periplasmic component
EV46_RS12130	COG2925	Exonuclease
EV46_RS12135	COG0531	amino acid
EV46_RS12145	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
EV46_RS12150	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
EV46_RS12170	COG3052	prosthetic group binding
EV46_RS12175	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
EV46_RS12180	COG0179	Fumarylacetoacetate (FAA) hydrolase
EV46_RS12185	COG3493	citrate carrier protein
EV46_RS12195	COG4565	transcriptional regulatory protein
EV46_RS12200	COG0840	transmembrane signaling receptor activity
EV46_RS12205	COG0840	transmembrane signaling receptor activity
EV46_RS12210	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EV46_RS12215	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EV46_RS12220	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
EV46_RS12225	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EV46_RS12230	COG0131	Imidazoleglycerol-phosphate dehydratase
EV46_RS12230	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EV46_RS12235	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EV46_RS12240	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EV46_RS12245	COG0107	imidazoleglycerol-phosphate synthase activity
EV46_RS12250	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
EV46_RS12250	COG0140	phosphoribosyl-ATP diphosphatase activity
EV46_RS12260	COG0776	regulation of translation
EV46_RS12265	COG0539	negative regulation of cytoplasmic translation
EV46_RS12270	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EV46_RS12275	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EV46_RS12280	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
EV46_RS12285	COG1944	ATP diphosphatase activity
EV46_RS12290	COG2116	formate transmembrane transporter activity
EV46_RS12295	COG1882	Formate acetyltransferase
EV46_RS12405	COG0582	viral genome integration into host DNA
EV46_RS12535	COG4695	Portal protein
EV46_RS12565	COG0338	D12 class N6 adenine-specific DNA methyltransferase
EV46_RS12600	COG4974	Belongs to the 'phage' integrase family
EV46_RS12605	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
EV46_RS12630	COG0477	Major facilitator Superfamily
EV46_RS12635	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EV46_RS12640	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EV46_RS12645	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
EV46_RS12650	COG1674	ftsk spoiiie
EV46_RS12650	COG3107	peptidoglycan biosynthetic process
EV46_RS12655	COG1522	sequence-specific DNA binding
EV46_RS12660	COG0492	ferredoxin-NADP+ reductase activity
EV46_RS12665	COG4988	ABC transporter
EV46_RS12670	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
EV46_RS12675	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
EV46_RS12680	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
EV46_RS12690	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EV46_RS12695	COG0542	response to heat
EV46_RS12700	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
EV46_RS12705	COG1278	Cold shock
EV46_RS12710	COG3593	DNA synthesis involved in DNA repair
EV46_RS12715	COG2431	L-lysine efflux transmembrane transporter activity
EV46_RS12720	COG1151	hydroxylamine reductase activity
EV46_RS12725	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EV46_RS12730	COG0702	epimerase
EV46_RS12735	COG3023	N-Acetylmuramoyl-L-alanine amidase
EV46_RS12740	COG0393	Putative heavy-metal-binding
EV46_RS12745	COG1126	abc transporter atp-binding protein
EV46_RS12750	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EV46_RS12755	COG4215	(ABC) transporter
EV46_RS12760	COG4160	amino acid transport
EV46_RS12765	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EV46_RS12770	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EV46_RS12780	COG1177	transmembrane transport
EV46_RS12785	COG1176	ABC-type spermidine putrescine transport system, permease component I
EV46_RS12790	COG3842	ATPase activity
EV46_RS12795	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
EV46_RS12805	COG0189	ligase activity
EV46_RS12825	COG2985	domain, Protein
EV46_RS12825	COG0569	domain protein
EV46_RS12830	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
EV46_RS12835	COG1349	DNA-binding transcription factor activity
EV46_RS12840	COG1686	Belongs to the peptidase S11 family
EV46_RS12845	COG2011	ABC-type metal ion transport system permease component
EV46_RS12850	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EV46_RS12855	COG1464	Belongs to the NlpA lipoprotein family
EV46_RS12860	COG0625	glutathione transferase activity
EV46_RS12865	COG2133	pyrroloquinoline quinone binding
EV46_RS12880	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
EV46_RS12890	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EV46_RS12910	COG0259	pyridoxamine-phosphate oxidase activity
EV46_RS12940	COG1028	Short-chain dehydrogenase reductase Sdr
EV46_RS12960	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EV46_RS12965	COG2949	membrane
EV46_RS12970	COG2311	Membrane
EV46_RS12975	COG0302	gtp cyclohydrolase
EV46_RS12980	COG0840	transmembrane signaling receptor activity
EV46_RS12985	COG0583	DNA-binding transcription factor activity
EV46_RS13010	COG0371	Dehydrogenase
EV46_RS13015	COG1129	ABC transporter
EV46_RS13020	COG1172	Belongs to the binding-protein-dependent transport system permease family
EV46_RS13025	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EV46_RS13030	COG4771	TonB-dependent receptor
EV46_RS13035	COG0833	amino acid
EV46_RS13040	COG0583	DNA-binding transcription factor activity
EV46_RS13045	COG2855	membrane
EV46_RS13050	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
EV46_RS13055	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EV46_RS13055	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
EV46_RS13055	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EV46_RS13060	COG1105	Belongs to the carbohydrate kinase PfkB family
EV46_RS13080	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EV46_RS13085	COG0523	cobalamin synthesis protein
EV46_RS13090	COG0671	phosphoesterase, PA-phosphatase related
EV46_RS13095	COG0791	NLP P60 protein
EV46_RS13100	COG4166	transmembrane transport
EV46_RS13105	COG4174	ABC transporter (Permease)
EV46_RS13110	COG4239	(ABC) transporter, permease
EV46_RS13115	COG4172	Belongs to the ABC transporter superfamily
EV46_RS13125	COG2814	Major facilitator Superfamily
EV46_RS13130	COG1187	pseudouridine synthase activity
EV46_RS13140	COG1061	Type III restriction enzyme res subunit
EV46_RS13145	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
EV46_RS13155	COG3081	Nucleoid-associated protein
EV46_RS13160	COG3082	Protein of unknown function (DUF1414)
EV46_RS13165	COG3083	sulfuric ester hydrolase activity
EV46_RS13175	COG0582	viral genome integration into host DNA
EV46_RS13230	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EV46_RS13235	COG0534	Mate efflux family protein
EV46_RS13240	COG2807	transmembrane transport
EV46_RS13245	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
EV46_RS13260	COG0783	Belongs to the Dps family
EV46_RS13265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EV46_RS13270	COG0765	amino acid transport
EV46_RS13275	COG1126	abc transporter atp-binding protein
EV46_RS13285	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EV46_RS13370	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
EV46_RS13385	COG1686	Belongs to the peptidase S11 family
EV46_RS13410	COG2040	homocysteine
EV46_RS13415	COG0833	amino acid
EV46_RS13420	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EV46_RS13425	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EV46_RS13430	COG0747	negative chemotaxis
EV46_RS13435	COG2195	Cleaves the N-terminal amino acid of tripeptides
EV46_RS13440	COG5654	RES domain protein
EV46_RS13445	COG5642	Protein of unknown function (DUF2384)
EV46_RS13450	COG0513	Belongs to the DEAD box helicase family
EV46_RS13455	COG1120	ATPase activity
EV46_RS13460	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EV46_RS13465	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EV46_RS13470	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EV46_RS13485	COG0670	Belongs to the BI1 family
EV46_RS13490	COG0314	molybdopterin synthase activity
EV46_RS13495	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
EV46_RS13500	COG0315	cyclic pyranopterin monophosphate synthase activity
EV46_RS13505	COG0521	Mo-molybdopterin cofactor biosynthetic process
EV46_RS13510	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EV46_RS13525	COG0556	nucleotide-excision repair
EV46_RS13530	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
EV46_RS13535	COG2226	methyltransferase
EV46_RS13540	COG0156	8-amino-7-oxononanoate synthase activity
EV46_RS13545	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EV46_RS13555	COG5297	Belongs to the glycosyl hydrolase family 6
EV46_RS13560	COG1380	Effector of murein hydrolase LrgA
EV46_RS13565	COG1346	cytolysis
EV46_RS13570	COG0295	cytidine deaminase activity
EV46_RS13575	COG0281	malic enzyme
EV46_RS13580	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EV46_RS13585	COG0601	transmembrane transport
EV46_RS13590	COG0747	negative chemotaxis
EV46_RS13595	COG4172	Belongs to the ABC transporter superfamily
EV46_RS13600	COG0303	'Molybdopterin
EV46_RS13605	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EV46_RS13625	COG2188	Transcriptional regulator
EV46_RS13635	COG0471	metal ion transport
EV46_RS13655	COG0583	DNA-binding transcription factor activity
EV46_RS13685	COG2003	Belongs to the UPF0758 family
EV46_RS13710	COG3596	GTP binding
EV46_RS13775	COG0084	hydrolase, TatD family'
EV46_RS13790	COG0582	viral genome integration into host DNA
EV46_RS13810	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EV46_RS13815	COG0322	excinuclease ABC activity
EV46_RS13820	COG2197	response regulator
EV46_RS13840	COG1113	amino acid transport
EV46_RS13880	COG1201	RNA secondary structure unwinding
EV46_RS13895	COG1028	Short-chain dehydrogenase reductase Sdr
EV46_RS13900	COG3046	protein related to deoxyribodipyrimidine photolyase
EV46_RS13925	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
EV46_RS13950	COG3451	type IV secretory pathway VirB4
EV46_RS13975	COG3736	Type IV secretory pathway, component VirB8
EV46_RS13980	COG3504	Conjugal transfer protein
EV46_RS13990	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
EV46_RS14030	COG4195	phage-related replication protein
EV46_RS14095	COG2801	Transposase and inactivated derivatives
EV46_RS14115	COG0583	DNA-binding transcription factor activity
EV46_RS14120	COG1902	pentaerythritol trinitrate reductase activity
EV46_RS14130	COG1028	Short-chain dehydrogenase reductase Sdr
EV46_RS14135	COG2814	Major facilitator Superfamily
EV46_RS14140	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EV46_RS14165	COG0300	oxidoreductase activity
EV46_RS14170	COG1733	regulation of RNA biosynthetic process
EV46_RS14175	COG2085	NADP oxidoreductase coenzyme F420-dependent
EV46_RS14190	COG3604	Transcriptional regulator
EV46_RS14195	COG2205	protein histidine kinase activity
EV46_RS14250	COG1309	transcriptional regulator
EV46_RS14255	COG2814	Major facilitator Superfamily
EV46_RS14280	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
EV46_RS14290	COG0659	secondary active sulfate transmembrane transporter activity
EV46_RS14295	COG4608	Belongs to the ABC transporter superfamily
EV46_RS14300	COG0444	Belongs to the ABC transporter superfamily
EV46_RS14310	COG0601	transmembrane transport
EV46_RS14315	COG0747	negative chemotaxis
EV46_RS14325	COG4948	Mandelate Racemase Muconate Lactonizing
EV46_RS14340	COG3713	MltA-interacting MipA family protein
EV46_RS14345	COG0745	RESPONSE REGULATOR receiver
EV46_RS14350	COG5000	phosphorelay sensor kinase activity
EV46_RS14350	COG5002	protein histidine kinase activity
EV46_RS14365	COG0765	amino acid transport
EV46_RS14370	COG0765	amino acid transport
EV46_RS14375	COG1126	abc transporter atp-binding protein
EV46_RS14405	COG0583	DNA-binding transcription factor activity
EV46_RS14420	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
EV46_RS14440	COG1902	pentaerythritol trinitrate reductase activity
EV46_RS14445	COG0640	Transcriptional regulator
EV46_RS14450	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
EV46_RS14455	COG4807	Protein conserved in bacteria
EV46_RS14460	COG1648	precorrin-2 dehydrogenase activity
EV46_RS14460	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EV46_RS14465	COG0243	molybdopterin cofactor binding
EV46_RS14470	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EV46_RS14470	COG2146	nitrite reductase [NAD(P)H] activity
EV46_RS14475	COG1116	anion transmembrane transporter activity
EV46_RS14485	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EV46_RS14490	COG3707	response regulator
EV46_RS14505	COG1271	oxidase subunit
EV46_RS14510	COG1294	oxidase, subunit
EV46_RS14515	COG2149	membrane
EV46_RS14525	COG3058	Necessary for formate dehydrogenase activity
EV46_RS14530	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EV46_RS14535	COG0519	Catalyzes the synthesis of GMP from XMP
EV46_RS14535	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EV46_RS14560	COG0488	(ABC) transporter
EV46_RS14575	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EV46_RS14575	COG1263	PTS System
EV46_RS14580	COG0366	Alpha amylase catalytic
EV46_RS14585	COG4575	ribosome binding
EV46_RS14590	COG1007	ATP synthesis coupled electron transport
EV46_RS14595	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EV46_RS14600	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EV46_RS14605	COG0713	ATP synthesis coupled electron transport
EV46_RS14610	COG0839	Belongs to the complex I subunit 6 family
EV46_RS14615	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EV46_RS14620	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
EV46_RS14630	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
EV46_RS14635	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
EV46_RS14640	COG0649	NAD binding
EV46_RS14640	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EV46_RS14645	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EV46_RS14650	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EV46_RS14655	COG0583	DNA-binding transcription factor activity
EV46_RS14660	COG0436	Aminotransferase
EV46_RS14665	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
EV46_RS14670	COG0471	metal ion transport
EV46_RS14670	COG0490	domain, Protein
EV46_RS14675	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EV46_RS14680	COG3013	Belongs to the UPF0304 family
EV46_RS14685	COG3092	negative regulation of chromosome organization
EV46_RS14690	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EV46_RS14695	COG0857	belongs to the CobB CobQ family
EV46_RS14695	COG0280	phosphate acetyltransferase
EV46_RS14700	COG3739	integral membrane protein
EV46_RS14705	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
EV46_RS14710	COG0622	Phosphoesterase
EV46_RS14715	COG0625	glutathione transferase activity
EV46_RS14720	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EV46_RS14725	COG1090	epimerase
EV46_RS14730	COG4598	ABC transporter
EV46_RS14735	COG4160	amino acid transport
EV46_RS14740	COG4215	(ABC) transporter
EV46_RS14750	COG0163	prenyltransferase activity
EV46_RS14755	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
EV46_RS14760	COG1286	toxin biosynthetic process
EV46_RS14765	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
EV46_RS14770	COG0285	dihydrofolate synthase activity
EV46_RS14775	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EV46_RS14785	COG0586	Pfam SNARE associated Golgi protein
EV46_RS14790	COG0101	tRNA pseudouridine synthase activity
EV46_RS14795	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EV46_RS14800	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EV46_RS14805	COG0697	spore germination
EV46_RS14815	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EV46_RS14820	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
EV46_RS14820	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EV46_RS14830	COG3101	peptidyl-lysine hydroxylation
EV46_RS14835	COG0730	response to heat
EV46_RS14840	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
EV46_RS14845	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
EV46_RS14850	COG2890	protein-(glutamine-N5) methyltransferase activity
EV46_RS14855	COG2840	Smr protein MutS2
EV46_RS14860	COG2062	phosphohistidine phosphatase, SixA
EV46_RS14880	COG3188	usher protein
EV46_RS14890	COG1024	Enoyl-CoA hydratase
EV46_RS14890	COG1250	3-hydroxyacyl-CoA dehydrogenase
EV46_RS14895	COG0183	Belongs to the thiolase family
EV46_RS14900	COG3691	Protein conserved in bacteria
EV46_RS14910	COG0579	oxidoreductase
EV46_RS14920	COG2116	formate transmembrane transporter activity
EV46_RS14965	COG0513	Belongs to the DEAD box helicase family
EV46_RS14975	COG1120	ATPase activity
EV46_RS14980	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EV46_RS14985	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EV46_RS14990	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EV46_RS15065	COG3866	Pectate lyase
EV46_RS15070	COG3266	domain, Protein
EV46_RS15080	COG0436	Aminotransferase
EV46_RS15085	COG4948	Mandelate Racemase Muconate Lactonizing
EV46_RS15095	COG3264	Mechanosensitive ion channel
EV46_RS15095	COG1511	domain protein
EV46_RS15145	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EV46_RS15150	COG1696	Membrane protein involved in D-alanine export
EV46_RS15180	COG1447	Phosphotransferase system cellobiose-specific component IIA
EV46_RS15195	COG3842	ATPase activity
EV46_RS15200	COG2076	Multidrug Resistance protein
EV46_RS15205	COG2076	Multidrug Resistance protein
EV46_RS15210	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
EV46_RS15215	COG0726	polysaccharide deacetylase
EV46_RS15220	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EV46_RS15220	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EV46_RS15225	COG0463	Glycosyl transferase, family 2
EV46_RS15230	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EV46_RS15235	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
EV46_RS15240	COG4251	negative regulation of phosphorylation
EV46_RS15240	COG3706	GGDEF domain
EV46_RS15240	COG2203	Gaf domain
EV46_RS15240	COG5001	Diguanylate cyclase
EV46_RS15245	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EV46_RS15250	COG2501	S4 domain
EV46_RS15255	COG0215	cysteine-tRNA ligase activity
EV46_RS15265	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EV46_RS15270	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EV46_RS15275	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EV46_RS15280	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EV46_RS15285	COG0814	amino acid
EV46_RS15290	COG1760	l-serine dehydratase
EV46_RS15300	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EV46_RS15305	COG0581	inorganic phosphate transmembrane transporter activity
EV46_RS15310	COG0573	inorganic phosphate transmembrane transporter activity
EV46_RS15315	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
EV46_RS15335	COG1764	response to oxidative stress
EV46_RS15340	COG1846	Transcriptional regulator
EV46_RS15345	COG2239	Acts as a magnesium transporter
EV46_RS15355	COG1085	galactose-1-phosphate uridylyltransferase
EV46_RS15360	COG1609	Transcriptional regulator
EV46_RS15365	COG4580	involved in the transport of maltose and maltodextrins
EV46_RS15370	COG3842	ATPase activity
EV46_RS15375	COG2182	Extracellular solute-binding protein
EV46_RS15380	COG1175	transmembrane transport
EV46_RS15385	COG3833	ABC-type maltose transport systems, permease component
EV46_RS15390	COG3867	Arabinogalactan endo-beta-1,4-galactanase
EV46_RS15395	COG1874	Beta-galactosidase
EV46_RS15405	COG0277	FAD linked oxidase domain protein
EV46_RS15415	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EV46_RS15420	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EV46_RS15425	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EV46_RS15430	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EV46_RS15440	COG0477	Major facilitator Superfamily
EV46_RS15445	COG2205	protein histidine kinase activity
EV46_RS15450	COG0745	RESPONSE REGULATOR receiver
EV46_RS15465	COG0435	Glutathione S-transferase
EV46_RS15470	COG0826	peptidase U32
EV46_RS15475	COG1597	lipid kinase activity
EV46_RS15480	COG3223	Belongs to the PsiE family
EV46_RS15490	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
EV46_RS15495	COG1064	alcohol dehydrogenase
EV46_RS15500	COG3706	GGDEF domain
EV46_RS15535	COG3423	Transcriptional regulator
EV46_RS15545	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EV46_RS15545	COG0519	Catalyzes the synthesis of GMP from XMP
EV46_RS15550	COG0516	GMP reductase activity
EV46_RS15550	COG0517	IMP dehydrogenase activity
EV46_RS15555	COG1570	exodeoxyribonuclease VII activity
EV46_RS15570	COG2207	Transcriptional regulator
EV46_RS15570	COG0662	Cupin 2, conserved barrel domain protein
EV46_RS15575	COG1028	Short-chain dehydrogenase reductase Sdr
EV46_RS15585	COG1160	GTP binding
EV46_RS15590	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EV46_RS15595	COG2976	Protein conserved in bacteria
EV46_RS15600	COG0124	histidyl-tRNA synthetase
EV46_RS15605	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
EV46_RS15610	COG1426	Protein conserved in bacteria
EV46_RS15620	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EV46_RS15625	COG0105	UTP biosynthetic process
EV46_RS15630	COG1263	PTS System
EV46_RS15630	COG2190	(PTS) system
EV46_RS15630	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EV46_RS15635	COG1486	melibiose metabolic process
EV46_RS15640	COG2897	thiosulfate sulfurtransferase activity
EV46_RS15645	COG1737	Transcriptional regulator
EV46_RS15655	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EV46_RS15660	COG2975	iron-sulfur cluster assembly
EV46_RS15665	COG0633	Ferredoxin
EV46_RS15670	COG0443	Heat shock 70 kDa protein
EV46_RS15675	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
EV46_RS15680	COG0316	Belongs to the HesB IscA family
EV46_RS15685	COG0822	iron-sulfur transferase activity
EV46_RS15690	COG1104	cysteine desulfurase activity
EV46_RS15695	COG1959	2 iron, 2 sulfur cluster binding
EV46_RS15700	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
EV46_RS15705	COG0483	inositol monophosphate 1-phosphatase activity
EV46_RS15715	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EV46_RS15730	COG0840	transmembrane signaling receptor activity
EV46_RS15740	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
EV46_RS15745	COG3683	transport system, periplasmic component
EV46_RS15750	COG2814	Major facilitator Superfamily
EV46_RS15760	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EV46_RS15765	COG1017	nitric oxide dioxygenase activity
EV46_RS15765	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EV46_RS15775	COG4677	pectinesterase activity
EV46_RS15780	COG0347	Belongs to the P(II) protein family
EV46_RS15785	COG2204	response regulator
EV46_RS15790	COG3170	Tfp pilus assembly protein FimV
EV46_RS15795	COG2205	protein histidine kinase activity
EV46_RS15800	COG0047	phosphoribosylformylglycinamidine synthase activity
EV46_RS15800	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EV46_RS15805	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
EV46_RS15815	COG0560	Phosphoserine phosphatase
EV46_RS15820	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
EV46_RS15830	COG3287	FIST C domain
EV46_RS15830	COG2200	EAL domain
EV46_RS15830	COG2199	diguanylate cyclase activity
EV46_RS15855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EV46_RS15865	COG2200	EAL domain
EV46_RS15870	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EV46_RS15875	COG0736	holo-[acyl-carrier-protein] synthase activity
EV46_RS15880	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
EV46_RS15885	COG1381	Involved in DNA repair and RecF pathway recombination
EV46_RS15890	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EV46_RS15895	COG0571	ribonuclease III activity
EV46_RS15905	COG0481	GTPase activity
EV46_RS15910	COG3086	response to oxidative stress
EV46_RS15915	COG3026	antisigma factor binding
EV46_RS15930	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
EV46_RS15935	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
EV46_RS15940	COG0513	Belongs to the DEAD box helicase family
EV46_RS15945	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
EV46_RS15950	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
EV46_RS15970	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EV46_RS15995	COG1902	pentaerythritol trinitrate reductase activity
EV46_RS16000	COG0667	Aldo Keto reductase
EV46_RS16015	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
EV46_RS16020	COG4208	sulfate ABC transporter
EV46_RS16030	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
EV46_RS16035	COG3835	regulator
EV46_RS16040	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EV46_RS16045	COG0232	Belongs to the dGTPase family. Type 2 subfamily
EV46_RS16050	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EV46_RS16055	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EV46_RS16065	COG0316	Belongs to the HesB IscA family
EV46_RS16070	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EV46_RS16075	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EV46_RS16085	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EV46_RS16090	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EV46_RS16095	COG1120	ATPase activity
EV46_RS16100	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EV46_RS16105	COG1643	Atp-dependent helicase
EV46_RS16110	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
EV46_RS16115	COG1489	DNA binding
EV46_RS16125	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EV46_RS16135	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EV46_RS16140	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EV46_RS16145	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
EV46_RS16150	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
EV46_RS16155	COG0842	Transport permease protein
EV46_RS16160	COG1131	(ABC) transporter
EV46_RS16165	COG0288	reversible hydration of carbon dioxide
EV46_RS16180	COG3842	ATPase activity
EV46_RS16195	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
EV46_RS16200	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
EV46_RS16205	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EV46_RS16210	COG1780	Probably involved in ribonucleotide reductase function
EV46_RS16235	COG0328	RNA-DNA hybrid ribonuclease activity
EV46_RS16240	COG2226	methyltransferase
EV46_RS16245	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EV46_RS16250	COG1388	LysM domain
EV46_RS16250	COG0741	lytic transglycosylase activity
EV46_RS16255	COG3021	interspecies interaction between organisms
EV46_RS16285	COG0542	response to heat
EV46_RS16295	COG0564	pseudouridine synthase activity
EV46_RS16300	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EV46_RS16305	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
EV46_RS16310	COG1605	Chorismate mutase
EV46_RS16310	COG0077	Prephenate dehydratase
EV46_RS16315	COG1605	Chorismate mutase
EV46_RS16315	COG0287	Prephenate dehydrogenase
EV46_RS16320	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EV46_RS16325	COG3279	Response regulator of the LytR AlgR family
EV46_RS16335	COG2264	protein methyltransferase activity
EV46_RS16340	COG0335	large ribosomal subunit rRNA binding
EV46_RS16345	COG0336	Belongs to the RNA methyltransferase TrmD family
EV46_RS16350	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EV46_RS16355	COG0228	four-way junction DNA binding
EV46_RS16360	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EV46_RS16365	COG4137	Cytochrome C assembly protein
EV46_RS16370	COG1854	S-ribosylhomocysteine lyase activity
EV46_RS16375	COG2918	glutathione biosynthetic process
EV46_RS16380	COG1238	metal cluster binding
EV46_RS16385	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EV46_RS16410	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
EV46_RS16415	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EV46_RS16420	COG2137	regulation of response to DNA damage stimulus
EV46_RS16425	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EV46_RS16430	COG1546	Belongs to the CinA family
EV46_RS16455	COG2814	Major facilitator Superfamily
EV46_RS16460	COG0583	DNA-binding transcription factor activity
EV46_RS16465	COG2999	glutathione oxidoreductase activity
EV46_RS16495	COG3209	COG3209 Rhs family protein
EV46_RS16520	COG4974	Belongs to the 'phage' integrase family
EV46_RS16530	COG3620	sequence-specific DNA binding
EV46_RS16555	COG4974	Belongs to the 'phage' integrase family
EV46_RS16560	COG0358	DNA primase activity
EV46_RS16580	COG3209	COG3209 Rhs family protein
EV46_RS16610	COG3501	Rhs element vgr protein
EV46_RS16645	COG3829	transcription factor binding
EV46_RS16710	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EV46_RS16735	COG2184	nucleotidyltransferase activity
EV46_RS16760	COG0582	viral genome integration into host DNA
EV46_RS16775	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EV46_RS16780	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
EV46_RS16790	COG1073	alpha beta
EV46_RS16795	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
EV46_RS16800	COG2195	Cleaves the N-terminal amino acid of tripeptides
EV46_RS16805	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EV46_RS16815	COG2226	methyltransferase
EV46_RS16820	COG3034	peptidoglycan biosynthetic process
EV46_RS16825	COG0121	glutamine amidotransferase
EV46_RS16830	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
EV46_RS16835	COG1960	acyl-CoA dehydrogenase activity
EV46_RS16850	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
EV46_RS16880	COG3501	Rhs element vgr protein
EV46_RS16885	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
EV46_RS16890	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
EV46_RS16895	COG0235	Class ii aldolase
EV46_RS16900	COG0436	Aminotransferase
EV46_RS16915	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EV46_RS16925	COG0765	amino acid transport
EV46_RS16970	COG4175	Glycine betaine
EV46_RS16975	COG4176	ABC-type proline glycine betaine transport system permease component
EV46_RS16980	COG2113	Glycine betaine
EV46_RS16985	COG0596	Alpha beta hydrolase
EV46_RS16995	COG2706	6-phosphogluconolactonase activity
EV46_RS17000	COG2814	Major facilitator Superfamily
EV46_RS17005	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
EV46_RS17015	COG1846	Transcriptional regulator
EV46_RS17020	COG1566	PFAM secretion protein HlyD family protein
EV46_RS17025	COG2814	Major facilitator Superfamily
EV46_RS17030	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EV46_RS17040	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EV46_RS17045	COG3118	belongs to the thioredoxin family
EV46_RS17050	COG3148	PFAM DTW domain containing protein
EV46_RS17055	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EV46_RS17055	COG1042	CoA-binding domain protein
EV46_RS17055	COG0045	succinate-CoA ligase (ADP-forming) activity
EV46_RS17060	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EV46_RS17065	COG5544	Lipoprotein
EV46_RS17070	COG0477	Major facilitator Superfamily
EV46_RS17105	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EV46_RS17110	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EV46_RS17115	COG2011	ABC-type metal ion transport system permease component
EV46_RS17120	COG1464	Belongs to the NlpA lipoprotein family
EV46_RS17130	COG1720	tRNA m6t6A37 methyltransferase activity
EV46_RS17135	COG0442	prolyl-tRNA aminoacylation
EV46_RS17145	COG4942	peptidase
EV46_RS17145	COG1388	LysM domain
EV46_RS17150	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EV46_RS17155	COG0585	pseudouridine synthase activity
EV46_RS17160	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
EV46_RS17165	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EV46_RS17170	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
EV46_RS17180	COG0765	amino acid transport
EV46_RS17185	COG1126	abc transporter atp-binding protein
EV46_RS17195	COG0529	Catalyzes the synthesis of activated sulfate
EV46_RS17200	COG2895	sulfate adenylyltransferase (ATP) activity
EV46_RS17205	COG0175	sulfate reduction
EV46_RS17210	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EV46_RS17210	COG1648	precorrin-2 dehydrogenase activity
EV46_RS17215	COG0175	sulfate reduction
EV46_RS17220	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EV46_RS17225	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EV46_RS17235	COG2200	EAL domain
EV46_RS17255	COG0720	synthase
EV46_RS17260	COG0602	queuosine metabolic process
EV46_RS17265	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EV46_RS17280	COG1028	Short-chain dehydrogenase reductase Sdr
EV46_RS17285	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
EV46_RS17310	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EV46_RS17320	COG0148	phosphopyruvate hydratase activity
EV46_RS17325	COG0504	CTP synthase activity
EV46_RS17330	COG3956	TIGRFAM MazG family protein
EV46_RS17335	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EV46_RS17340	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EV46_RS17350	COG1929	Belongs to the glycerate kinase type-1 family
EV46_RS17355	COG2084	Dehydrogenase
EV46_RS17365	COG4948	Mandelate Racemase Muconate Lactonizing
EV46_RS17370	COG4948	Mandelate Racemase Muconate Lactonizing
EV46_RS17375	COG2271	Major facilitator Superfamily
EV46_RS17380	COG2721	sulfolactate sulfo-lyase activity
EV46_RS17385	COG0840	transmembrane signaling receptor activity
EV46_RS17400	COG3530	Putative quorum-sensing-regulated virulence factor
EV46_RS17405	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EV46_RS17410	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
EV46_RS17410	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
EV46_RS17415	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
EV46_RS17420	COG3025	triphosphatase activity
EV46_RS17425	COG4991	sh3 domain protein
EV46_RS17430	COG0617	tRNA 3'-terminal CCA addition
EV46_RS17435	COG1968	undecaprenyl-diphosphatase activity
EV46_RS17440	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EV46_RS17445	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
EV46_RS17450	COG0840	transmembrane signaling receptor activity
EV46_RS17455	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
EV46_RS17460	COG2105	PFAM AIG2 family protein
EV46_RS17465	COG2911	Protein conserved in bacteria
EV46_RS17470	COG0729	surface antigen
EV46_RS17475	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EV46_RS17480	COG1253	flavin adenine dinucleotide binding
EV46_RS17490	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
EV46_RS17495	COG1218	3'(2'),5'-bisphosphate nucleotidase
EV46_RS17500	COG0737	Belongs to the 5'-nucleotidase family
EV46_RS17515	COG3961	Belongs to the TPP enzyme family
EV46_RS17520	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
EV46_RS17525	COG0545	Peptidyl-prolyl cis-trans isomerase
EV46_RS17530	COG3061	Opacity-associated protein A
EV46_RS17540	COG0359	binds to the 23S rRNA
EV46_RS17545	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
EV46_RS17550	COG0360	Binds together with S18 to 16S ribosomal RNA
EV46_RS17555	COG1073	alpha beta
EV46_RS17560	COG0840	transmembrane signaling receptor activity
EV46_RS17565	COG1690	Belongs to the RtcB family
EV46_RS17570	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
EV46_RS17590	COG3766	membrane
EV46_RS17595	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EV46_RS17600	COG0557	exoribonuclease II activity
EV46_RS17605	COG1959	2 iron, 2 sulfur cluster binding
EV46_RS17610	COG0840	transmembrane signaling receptor activity
EV46_RS17620	COG2805	Type II/IV secretion system protein
EV46_RS17625	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EV46_RS17630	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EV46_RS17635	COG0762	integral membrane protein
EV46_RS17640	COG1872	DUF167
EV46_RS17645	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
EV46_RS17650	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EV46_RS17660	COG0583	DNA-binding transcription factor activity
EV46_RS17685	COG2153	protein acetylation
EV46_RS17690	COG0477	Major facilitator Superfamily
EV46_RS17695	COG0204	Acyl-transferase
EV46_RS17695	COG0318	PFAM AMP-dependent synthetase and ligase
EV46_RS17700	COG0840	transmembrane signaling receptor activity
EV46_RS17710	COG2186	Transcriptional regulator
EV46_RS17715	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EV46_RS17720	COG2723	6-phospho-beta-galactosidase activity
EV46_RS17725	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EV46_RS17730	COG1447	Phosphotransferase system cellobiose-specific component IIA
EV46_RS17735	COG1609	Transcriptional regulator
EV46_RS17740	COG1396	sequence-specific DNA binding
EV46_RS17755	COG0583	DNA-binding transcription factor activity
EV46_RS17760	COG0583	DNA-binding transcription factor activity
EV46_RS17790	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EV46_RS17800	COG2124	cytochrome p450
EV46_RS17815	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EV46_RS17830	COG1522	sequence-specific DNA binding
EV46_RS17840	COG1448	Aminotransferase
EV46_RS17845	COG1451	nucleotide metabolic process
EV46_RS17870	COG1518	maintenance of DNA repeat elements
EV46_RS17875	COG1203	CRISPR-associated helicase, Cas3
EV46_RS17915	COG0432	Pfam Uncharacterised protein family UPF0047
EV46_RS17920	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EV46_RS17945	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EV46_RS17965	COG0395	ABC-type sugar transport system, permease component
EV46_RS17970	COG1175	transmembrane transport
EV46_RS17975	COG3842	ATPase activity
EV46_RS17980	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
EV46_RS18000	COG2971	BadF BadG BcrA BcrD
EV46_RS18010	COG1121	(ABC) transporter
EV46_RS18015	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EV46_RS18020	COG0803	Belongs to the bacterial solute-binding protein 9 family
EV46_RS18025	COG1349	DNA-binding transcription factor activity
EV46_RS18030	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
EV46_RS18035	COG3395	kinase activity
EV46_RS18040	COG1454	alcohol dehydrogenase
EV46_RS18045	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EV46_RS18060	COG2731	YhcH YjgK YiaL family protein
EV46_RS18065	COG1028	Short-chain dehydrogenase reductase Sdr
EV46_RS18070	COG1882	Formate acetyltransferase
EV46_RS18075	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
EV46_RS18090	COG1609	Transcriptional regulator
EV46_RS18095	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EV46_RS18110	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
EV46_RS18115	COG3112	Uncharacterised protein family (UPF0231)
EV46_RS18130	COG0640	Transcriptional regulator
EV46_RS18140	COG2207	Transcriptional regulator
EV46_RS18145	COG2079	MmgE PrpD family protein
EV46_RS18150	COG1073	alpha beta
EV46_RS18160	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EV46_RS18165	COG0508	dehydrogenase complex catalyzes the overall conversion of
EV46_RS18170	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
EV46_RS18180	COG1113	amino acid transport
EV46_RS18185	COG2211	Major facilitator Superfamily
EV46_RS18190	COG3940	Belongs to the glycosyl hydrolase 43 family
EV46_RS18195	COG3725	Membrane protein required for beta-lactamase induction
EV46_RS18200	COG3023	N-Acetylmuramoyl-L-alanine amidase
EV46_RS18205	COG3248	Nucleoside-binding outer membrane protein
EV46_RS18210	COG0157	Belongs to the NadC ModD family
EV46_RS18215	COG4969	Belongs to the N-Me-Phe pilin family
EV46_RS18220	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EV46_RS18225	COG1459	type II secretion system
EV46_RS18230	COG0516	GMP reductase activity
EV46_RS18235	COG0237	dephospho-CoA kinase activity
EV46_RS18240	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
EV46_RS18245	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
EV46_RS18250	COG0494	nUDIX hydrolase
EV46_RS18255	COG0653	protein targeting
EV46_RS18270	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
EV46_RS18275	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EV46_RS18280	COG0849	cell division
EV46_RS18285	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EV46_RS18290	COG1181	Belongs to the D-alanine--D-alanine ligase family
EV46_RS18295	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EV46_RS18300	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EV46_RS18305	COG0772	Belongs to the SEDS family
EV46_RS18310	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EV46_RS18315	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EV46_RS18320	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EV46_RS18325	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EV46_RS18330	COG0768	penicillin binding
EV46_RS18335	COG3116	cell division
EV46_RS18340	COG0275	rRNA processing
EV46_RS18345	COG2001	Belongs to the MraZ family
EV46_RS18365	COG0028	Belongs to the TPP enzyme family
EV46_RS18370	COG1022	Amp-dependent synthetase and ligase
EV46_RS18375	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EV46_RS18380	COG0473	3-isopropylmalate dehydrogenase activity
EV46_RS18385	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EV46_RS18390	COG0066	3-isopropylmalate dehydratase activity
EV46_RS18410	COG0840	transmembrane signaling receptor activity
EV46_RS18430	COG4533	DNA binding
EV46_RS18445	COG4143	(ABC) transporter
EV46_RS18450	COG1178	ABC-type Fe3 transport system permease component
EV46_RS18455	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
EV46_RS18460	COG3507	Belongs to the glycosyl hydrolase 43 family
EV46_RS18465	COG0028	Belongs to the TPP enzyme family
EV46_RS18470	COG0440	acetolactate synthase activity
EV46_RS18475	COG0586	Pfam SNARE associated Golgi protein
EV46_RS18480	COG3706	GGDEF domain
EV46_RS18485	COG0417	DNA replication proofreading
EV46_RS18490	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EV46_RS18495	COG0564	pseudouridine synthase activity
EV46_RS18500	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
EV46_RS18505	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
EV46_RS18510	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EV46_RS18515	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
EV46_RS18520	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EV46_RS18525	COG2967	ApaG domain
EV46_RS18530	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EV46_RS18550	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
EV46_RS18555	COG3610	response to peptide
EV46_RS18560	COG2966	Psort location CytoplasmicMembrane, score
EV46_RS18570	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EV46_RS18575	COG0505	Belongs to the CarA family
EV46_RS18580	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EV46_RS18585	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EV46_RS18590	COG1047	Peptidyl-prolyl cis-trans
EV46_RS18600	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EV46_RS18605	COG0196	riboflavin kinase activity
EV46_RS18610	COG0268	Binds directly to 16S ribosomal RNA
EV46_RS18615	COG0583	DNA-binding transcription factor activity
EV46_RS18620	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EV46_RS18625	COG0484	heat shock protein binding
EV46_RS18630	COG0443	Heat shock 70 kDa protein
EV46_RS18635	COG1584	GPR1 FUN34 yaaH family protein
EV46_RS18645	COG0521	Mo-molybdopterin cofactor biosynthetic process
EV46_RS18655	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
EV46_RS18660	COG3022	response to hydroperoxide
EV46_RS18670	COG0083	homoserine kinase activity
EV46_RS18680	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
EV46_RS18685	COG0745	RESPONSE REGULATOR receiver
EV46_RS18690	COG3045	CreA protein
EV46_RS18700	COG3708	Transcriptional regulator
EV46_RS18700	COG2207	Transcriptional regulator
EV46_RS18710	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
EV46_RS18715	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
EV46_RS18725	COG0488	(ABC) transporter
EV46_RS18730	COG0840	transmembrane signaling receptor activity
EV46_RS18735	COG0583	DNA-binding transcription factor activity
EV46_RS18740	COG0604	alcohol dehydrogenase
EV46_RS18745	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EV46_RS18750	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
EV46_RS18755	COG0583	DNA-binding transcription factor activity
EV46_RS18765	COG1279	arginine transmembrane transporter activity
EV46_RS18770	COG0668	transmembrane transport
EV46_RS18775	COG0191	fructose-bisphosphate aldolase activity
EV46_RS18780	COG0126	phosphoglycerate kinase activity
EV46_RS18785	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EV46_RS18790	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EV46_RS18795	COG0501	Belongs to the peptidase M48B family
EV46_RS18805	COG1166	arginine decarboxylase activity
EV46_RS18810	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EV46_RS18815	COG3091	SprT-like family
EV46_RS18820	COG2356	endonuclease I
EV46_RS18825	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EV46_RS18830	COG0189	ligase activity
EV46_RS18835	COG1678	Uncharacterized ACR, COG1678
EV46_RS18840	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EV46_RS18845	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
EV46_RS18850	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EV46_RS18855	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
EV46_RS18860	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
EV46_RS18865	COG0330	HflC and HflK could
EV46_RS18870	COG0330	HflC and HflK could
EV46_RS18875	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EV46_RS18880	COG1923	regulation of RNA biosynthetic process
EV46_RS18885	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EV46_RS18890	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EV46_RS18895	COG0860	N-Acetylmuramoyl-L-alanine amidase
EV46_RS18900	COG0802	atpase or kinase
EV46_RS18905	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
EV46_RS18905	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
EV46_RS18910	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EV46_RS18925	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
EV46_RS18940	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EV46_RS18950	COG1064	alcohol dehydrogenase
EV46_RS18970	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
EV46_RS18975	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EV46_RS18985	COG1011	Hydrolase
EV46_RS19030	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
EV46_RS19035	COG1162	GTPase activity
EV46_RS19040	COG0688	phosphatidylethanolamine metabolic process
EV46_RS19045	COG3264	Mechanosensitive ion channel
EV46_RS19045	COG1511	domain protein
EV46_RS19050	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
EV46_RS19055	COG1053	succinate dehydrogenase
EV46_RS19060	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EV46_RS19065	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
EV46_RS19070	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
EV46_RS19075	COG3040	lipid binding
EV46_RS19090	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EV46_RS19095	COG1509	lysine 2,3-aminomutase activity
EV46_RS19105	COG0166	Belongs to the GPI family
EV46_RS19110	COG0527	aspartate kinase activity
EV46_RS19120	COG0471	metal ion transport
EV46_RS19130	COG4977	sequence-specific DNA binding
EV46_RS19130	COG1917	Cupin 2, conserved barrel domain protein
EV46_RS19135	COG0646	methionine synthase
EV46_RS19135	COG1410	methionine synthase
EV46_RS19180	COG3267	Type II secretory pathway component ExeA
EV46_RS19180	COG3409	Peptidoglycan-binding domain 1 protein
EV46_RS19235	COG1196	nuclear chromosome segregation
EV46_RS19235	COG0741	lytic transglycosylase activity
EV46_RS19235	COG0739	heme binding
EV46_RS19260	COG4373	Mu-like prophage FluMu protein gp28
EV46_RS19270	COG2369	cell adhesion
EV46_RS19395	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
EV46_RS19405	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
EV46_RS19410	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
EV46_RS19440	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
EV46_RS19450	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EV46_RS19455	COG0009	L-threonylcarbamoyladenylate synthase
EV46_RS19460	COG0551	DNA topoisomerase type I activity
EV46_RS19465	COG2922	Belongs to the Smg family
EV46_RS19470	COG0758	DNA mediated transformation
EV46_RS19475	COG0242	peptide deformylase activity
EV46_RS19480	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EV46_RS19485	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EV46_RS19485	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EV46_RS19490	COG0569	domain protein
EV46_RS19495	COG1970	mechanosensitive ion channel activity
EV46_RS19500	COG3036	rescue of stalled ribosome
EV46_RS19505	COG0203	ribosomal protein L17
EV46_RS19510	COG0202	RNA polymerase activity
EV46_RS19515	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EV46_RS19525	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EV46_RS19530	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EV46_RS19535	COG0201	protein transport
EV46_RS19540	COG0200	Binds to the 23S rRNA
EV46_RS19545	COG1841	ribosomal large subunit assembly
EV46_RS19550	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
EV46_RS19555	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EV46_RS19560	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
EV46_RS19565	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EV46_RS19570	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
EV46_RS19575	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EV46_RS19580	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EV46_RS19590	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EV46_RS19595	COG0255	Belongs to the universal ribosomal protein uL29 family
EV46_RS19600	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
EV46_RS19605	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
EV46_RS19610	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EV46_RS19615	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EV46_RS19620	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EV46_RS19625	COG0089	rRNA binding
EV46_RS19630	COG0088	Forms part of the polypeptide exit tunnel
EV46_RS19635	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EV46_RS19640	COG0051	transcription antitermination factor activity, RNA binding
EV46_RS19655	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EV46_RS19660	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EV46_RS19665	COG0049	tRNA binding
EV46_RS19670	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EV46_RS19675	COG2168	tRNA wobble position uridine thiolation
EV46_RS19680	COG2923	Belongs to the DsrF TusC family
EV46_RS19685	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
EV46_RS19690	COG2964	Protein conserved in bacteria
EV46_RS19700	COG0745	RESPONSE REGULATOR receiver
EV46_RS19705	COG0642	Histidine kinase
EV46_RS19710	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EV46_RS19725	COG0545	Peptidyl-prolyl cis-trans isomerase
EV46_RS19730	COG2900	Belongs to the SlyX family
EV46_RS19735	COG1733	regulation of RNA biosynthetic process
EV46_RS19750	COG1047	Peptidyl-prolyl cis-trans
EV46_RS19755	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
EV46_RS19760	COG0475	glutathione-regulated potassium exporter activity
EV46_RS19760	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EV46_RS19765	COG2249	NAD(P)H dehydrogenase (quinone) activity
EV46_RS19770	COG0488	(ABC) transporter
EV46_RS19780	COG0429	hydrolase of the alpha beta-hydrolase fold
EV46_RS19785	COG3089	Belongs to the UPF0270 family
EV46_RS19790	COG3954	Phosphoribulokinase
EV46_RS19795	COG1765	OsmC-like protein
EV46_RS19800	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EV46_RS19815	COG3866	Pectate lyase
EV46_RS19820	COG3866	Pectate lyase
EV46_RS19825	COG3866	Pectate lyase
EV46_RS19835	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EV46_RS19840	COG4608	Belongs to the ABC transporter superfamily
EV46_RS19845	COG0444	Belongs to the ABC transporter superfamily
EV46_RS19850	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EV46_RS19855	COG0601	transmembrane transport
EV46_RS19860	COG0747	negative chemotaxis
EV46_RS19865	COG4948	Mandelate Racemase Muconate Lactonizing
EV46_RS19875	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EV46_RS19885	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EV46_RS19885	COG1648	precorrin-2 dehydrogenase activity
EV46_RS19910	COG1473	amidohydrolase
EV46_RS19920	COG0546	phosphoglycolate phosphatase activity
EV46_RS19925	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EV46_RS19940	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EV46_RS19945	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EV46_RS19950	COG4796	Type ii and iii secretion system protein
EV46_RS19975	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
EV46_RS19980	COG0494	nUDIX hydrolase
EV46_RS19990	COG1011	Hydrolase
EV46_RS19995	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
EV46_RS20000	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
EV46_RS20005	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
EV46_RS20030	COG2814	Major facilitator Superfamily
EV46_RS20035	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EV46_RS20040	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EV46_RS20045	COG0019	diaminopimelate decarboxylase activity
EV46_RS20050	COG4774	siderophore transport
EV46_RS20055	COG4264	IucA IucC family
EV46_RS20065	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EV46_RS20075	COG0840	transmembrane signaling receptor activity
EV46_RS20085	COG2183	response to ionizing radiation
EV46_RS20090	COG1414	Transcriptional regulator
EV46_RS20115	COG1136	(ABC) transporter
EV46_RS20125	COG1785	Belongs to the alkaline phosphatase family
EV46_RS20130	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EV46_RS20135	COG2267	carboxylic ester hydrolase activity
EV46_RS20140	COG1040	competence protein
EV46_RS20145	COG0316	Belongs to the HesB IscA family
EV46_RS20145	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
EV46_RS20150	COG1640	4-alpha-glucanotransferase
EV46_RS20155	COG0058	SHG alpha-glucan phosphorylase activity
EV46_RS20160	COG1349	DNA-binding transcription factor activity
EV46_RS20165	COG0705	Rhomboid family
EV46_RS20170	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EV46_RS20180	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EV46_RS20185	COG3501	Rhs element vgr protein
EV46_RS20210	COG0058	SHG alpha-glucan phosphorylase activity
EV46_RS20215	COG0297	glycogen (starch) synthase activity
EV46_RS20220	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EV46_RS20225	COG1523	belongs to the glycosyl hydrolase 13 family
EV46_RS20230	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
EV46_RS20235	COG3275	phosphorelay sensor kinase activity
EV46_RS20250	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EV46_RS20255	COG2095	MarC family integral membrane protein
EV46_RS20265	COG3265	gluconokinase activity
EV46_RS20270	COG1609	Transcriptional regulator
EV46_RS20280	COG1741	Belongs to the pirin family
EV46_RS20285	COG0247	lactate metabolic process
EV46_RS20290	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
EV46_RS20295	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EV46_RS20300	COG2271	Major facilitator Superfamily
EV46_RS20305	COG0584	glycerophosphoryl diester phosphodiesterase
EV46_RS20310	COG0561	phosphatase activity
EV46_RS20315	COG2267	carboxylic ester hydrolase activity
EV46_RS20320	COG1280	lysine exporter protein (LysE YggA)
EV46_RS20325	COG1280	lysine exporter protein (LysE YggA)
EV46_RS20330	COG0514	ATP-dependent DNA helicase (RecQ)
EV46_RS20345	COG2050	protein possibly involved in aromatic compounds catabolism
EV46_RS20355	COG3180	Ammonia monooxygenase
EV46_RS20360	COG0598	Magnesium transport protein CorA
EV46_RS20365	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
EV46_RS20370	COG0210	DNA helicase
EV46_RS20375	COG1011	Hydrolase
EV46_RS20390	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
EV46_RS20400	COG1965	Belongs to the frataxin family
EV46_RS20415	COG0181	hydroxymethylbilane synthase activity
EV46_RS20420	COG1587	Uroporphyrinogen-III synthase
EV46_RS20425	COG2959	enzyme of heme biosynthesis
EV46_RS20430	COG3071	HemY protein
EV46_RS20435	COG1473	amidohydrolase
EV46_RS20440	COG1126	abc transporter atp-binding protein
EV46_RS20445	COG0765	amino acid transport
EV46_RS20450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EV46_RS20455	COG0456	acetyltransferase
EV46_RS20460	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EV46_RS20495	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
EV46_RS20505	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EV46_RS20510	COG2244	polysaccharide biosynthetic process
EV46_RS20515	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EV46_RS20520	COG0456	acetyltransferase
EV46_RS20525	COG1088	dTDP-glucose 4,6-dehydratase activity
EV46_RS20530	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
EV46_RS20535	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
EV46_RS20540	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
EV46_RS20545	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EV46_RS20550	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
EV46_RS20555	COG3118	belongs to the thioredoxin family
EV46_RS20560	COG0513	Belongs to the DEAD box helicase family
EV46_RS20565	COG0248	Ppx GppA phosphatase
EV46_RS20575	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EV46_RS20580	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
EV46_RS20580	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
EV46_RS20580	COG0506	proline dehydrogenase activity
EV46_RS20590	COG0583	DNA-binding transcription factor activity
EV46_RS20600	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
EV46_RS20605	COG0583	DNA-binding transcription factor activity
EV46_RS20625	COG0129	dihydroxy-acid dehydratase activity
EV46_RS20635	COG3978	acetolactate synthase activity
EV46_RS20645	COG0606	chelatase, subunit chli
EV46_RS20650	COG3085	chromosome segregation
EV46_RS20655	COG0583	DNA-binding transcription factor activity
EV46_RS20660	COG1172	Belongs to the binding-protein-dependent transport system permease family
EV46_RS20665	COG1172	Belongs to the binding-protein-dependent transport system permease family
EV46_RS20670	COG1129	ABC transporter
EV46_RS20675	COG1879	ABC-type sugar transport system periplasmic component
EV46_RS20710	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
EV46_RS20715	COG4206	TonB-dependent receptor
EV46_RS20720	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EV46_RS20735	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EV46_RS20755	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
EV46_RS20760	COG1609	Transcriptional regulator
EV46_RS20765	COG0395	ABC-type sugar transport system, permease component
EV46_RS20780	COG3842	ATPase activity
EV46_RS20785	COG0460	homoserine dehydrogenase
EV46_RS20785	COG0527	aspartate kinase activity
EV46_RS20790	COG0626	cystathionine gamma-synthase activity
EV46_RS20795	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
EV46_RS20800	COG1120	ATPase activity
EV46_RS20810	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EV46_RS20815	COG0254	rRNA binding
EV46_RS20820	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EV46_RS20825	COG1609	Transcriptional regulator
EV46_RS20830	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
EV46_RS20835	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
EV46_RS20840	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
EV46_RS20845	COG1575	Belongs to the MenA family. Type 1 subfamily
EV46_RS20850	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EV46_RS20855	COG3074	FtsZ-dependent cytokinesis
EV46_RS20860	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EV46_RS20870	COG1494	fructose-1,6-bisphosphatase
EV46_RS20880	COG3152	Membrane
EV46_RS20890	COG0149	triose-phosphate isomerase activity
EV46_RS20895	COG2957	Belongs to the agmatine deiminase family
EV46_RS20900	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EV46_RS20910	COG3501	Rhs element vgr protein
EV46_RS20920	COG3209	COG3209 Rhs family protein
EV46_RS20920	COG4104	PAAR repeat-containing protein
EV46_RS20940	COG1116	anion transmembrane transporter activity
EV46_RS20945	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EV46_RS20985	COG0583	DNA-binding transcription factor activity
EV46_RS20990	COG0205	6-phosphofructokinase activity
EV46_RS20995	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EV46_RS21000	COG2814	Major facilitator Superfamily
EV46_RS21005	COG3678	ATP-independent chaperone mediated protein folding
EV46_RS21010	COG0745	RESPONSE REGULATOR receiver
EV46_RS21015	COG2205	protein histidine kinase activity
EV46_RS21030	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EV46_RS21045	COG0584	glycerophosphoryl diester phosphodiesterase
EV46_RS21050	COG3842	ATPase activity
EV46_RS21055	COG0395	ABC-type sugar transport system, permease component
EV46_RS21060	COG1175	transmembrane transport
EV46_RS21065	COG1653	transport
EV46_RS21080	COG1349	DNA-binding transcription factor activity
EV46_RS21090	COG2084	Dehydrogenase
EV46_RS21095	COG3395	kinase activity
EV46_RS21100	COG0235	Class ii aldolase
EV46_RS21105	COG3622	Belongs to the hyi family
EV46_RS21110	COG2610	gluconate transmembrane transporter activity
EV46_RS21115	COG0840	transmembrane signaling receptor activity
EV46_RS21125	COG0840	transmembrane signaling receptor activity
EV46_RS21135	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EV46_RS21145	COG0411	ABC transporter
EV46_RS21150	COG4177	L-phenylalanine transmembrane transporter activity
EV46_RS21155	COG0559	Belongs to the binding-protein-dependent transport system permease family
EV46_RS21160	COG0683	leucine binding
EV46_RS21175	COG2177	Part of the ABC transporter FtsEX involved in
EV46_RS21180	COG2884	Cell division ATP-binding protein ftsE
EV46_RS21185	COG0552	protein localization to endoplasmic reticulum
EV46_RS21190	COG0742	ribosomal rna small subunit methyltransferase
EV46_RS21195	COG3776	membrane
EV46_RS21210	COG3714	YhhN family
EV46_RS21220	COG0425	Belongs to the sulfur carrier protein TusA family
EV46_RS21225	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
EV46_RS21245	COG0477	Major facilitator Superfamily
EV46_RS21250	COG1295	ribonuclease BN
EV46_RS21255	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EV46_RS21260	COG0612	Peptidase, M16
EV46_RS21265	COG1301	dicarboxylic acid transport
EV46_RS21270	COG2199	diguanylate cyclase activity
EV46_RS21270	COG2200	EAL domain
EV46_RS21295	COG1192	Involved in chromosome partitioning
EV46_RS21315	COG3118	belongs to the thioredoxin family
EV46_RS21315	COG0457	Tetratricopeptide repeat
EV46_RS21335	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EV46_RS21345	COG2271	Major facilitator Superfamily
EV46_RS21350	COG1802	Transcriptional regulator
EV46_RS21355	COG1063	alcohol dehydrogenase
EV46_RS21375	COG3977	Valine--pyruvate aminotransferase
EV46_RS21380	COG2723	6-phospho-beta-galactosidase activity
EV46_RS21385	COG1263	PTS System
EV46_RS21385	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EV46_RS21385	COG2190	(PTS) system
EV46_RS21390	COG3711	transcriptional antiterminator
EV46_RS21395	COG4608	Belongs to the ABC transporter superfamily
EV46_RS21400	COG0444	Belongs to the ABC transporter superfamily
EV46_RS21405	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EV46_RS21410	COG0601	transmembrane transport
EV46_RS21415	COG0747	negative chemotaxis
EV46_RS21420	COG3493	citrate carrier protein
EV46_RS21435	COG4565	transcriptional regulatory protein
EV46_RS21440	COG3290	protein histidine kinase activity
EV46_RS21445	COG0471	metal ion transport
EV46_RS21450	COG2985	domain, Protein
EV46_RS21450	COG0569	domain protein
EV46_RS21455	COG0071	Belongs to the small heat shock protein (HSP20) family
EV46_RS21460	COG0071	Belongs to the small heat shock protein (HSP20) family
EV46_RS21465	COG5645	(Lipo)protein
EV46_RS21470	COG0823	Involved in the tonB-independent uptake of proteins
EV46_RS21480	COG2723	6-phospho-beta-galactosidase activity
EV46_RS21485	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EV46_RS21485	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EV46_RS21490	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EV46_RS21495	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EV46_RS21500	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EV46_RS21505	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EV46_RS21510	COG1116	anion transmembrane transporter activity
EV46_RS21520	COG2271	Major facilitator Superfamily
EV46_RS21525	COG4948	Mandelate Racemase Muconate Lactonizing
EV46_RS21530	COG0800	Aldolase
EV46_RS21535	COG3734	2-keto-3-deoxy-galactonokinase
EV46_RS21550	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
EV46_RS21565	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EV46_RS21570	COG0601	transmembrane transport
EV46_RS21585	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EV46_RS21600	COG0561	phosphatase activity
EV46_RS21620	COG2723	6-phospho-beta-galactosidase activity
EV46_RS21625	COG1447	Phosphotransferase system cellobiose-specific component IIA
EV46_RS21630	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EV46_RS21635	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EV46_RS21640	COG1609	Transcriptional regulator
EV46_RS21655	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EV46_RS21660	COG0592	DNA-directed DNA polymerase activity
EV46_RS21665	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EV46_RS21670	COG0594	ribonuclease P activity
EV46_RS21675	COG0706	membrane insertase activity
EV46_RS21680	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EV46_RS21695	COG0702	epimerase
EV46_RS21700	COG1733	regulation of RNA biosynthetic process
EV46_RS21705	COG1215	transferase activity, transferring glycosyl groups
EV46_RS21710	COG0726	polysaccharide deacetylase
EV46_RS21710	COG1649	PFAM Uncharacterised BCR, COG1649
EV46_RS21715	COG0457	Tetratricopeptide repeat
EV46_RS21750	COG0493	'glutamate synthase
EV46_RS21750	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
EV46_RS21755	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
EV46_RS21760	COG2091	lysine biosynthetic process via aminoadipic acid
EV46_RS21765	COG2252	PERMEase
EV46_RS21770	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EV46_RS21775	COG0765	amino acid transport
EV46_RS21780	COG0765	amino acid transport
EV46_RS21785	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EV46_RS21790	COG3135	benzoate transporter
EV46_RS21795	COG1396	sequence-specific DNA binding
EV46_RS21805	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EV46_RS21810	COG0581	inorganic phosphate transmembrane transporter activity
EV46_RS21815	COG0573	inorganic phosphate transmembrane transporter activity
EV46_RS21820	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EV46_RS21825	COG1126	abc transporter atp-binding protein
EV46_RS21830	COG0765	amino acid transport
EV46_RS21840	COG4221	oxidoreductase activity
EV46_RS21855	COG0436	Aminotransferase
EV46_RS21860	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
EV46_RS21865	COG1984	allophanate hydrolase subunit 2
EV46_RS21875	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EV46_RS21880	COG0697	spore germination
EV46_RS21890	COG1028	Short-chain dehydrogenase reductase Sdr
EV46_RS21900	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EV46_RS21925	COG1216	Glycosyl transferase, family 2
EV46_RS21930	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EV46_RS21935	COG0318	PFAM AMP-dependent synthetase and ligase
EV46_RS21945	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EV46_RS21950	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EV46_RS21970	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EV46_RS21975	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EV46_RS21985	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EV46_RS21990	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EV46_RS21995	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EV46_RS22000	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EV46_RS22005	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EV46_RS22010	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EV46_RS22020	COG0356	it plays a direct role in the translocation of protons across the membrane
EV46_RS22025	COG3312	ion transport
EV46_RS22030	COG0357	Ribosomal RNA small subunit methyltransferase G
EV46_RS22035	COG0445	tRNA wobble uridine modification