locus-tag	class	description
H5A30_RS00030	COG0741	lytic transglycosylase activity
H5A30_RS00085	COG0629	single-stranded DNA binding
H5A30_RS00095	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H5A30_RS00135	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H5A30_RS00145	COG0305	Participates in initiation and elongation during chromosome replication
H5A30_RS00160	COG0582	viral genome integration into host DNA
H5A30_RS00215	COG3423	Transcriptional regulator
H5A30_RS00235	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
H5A30_RS00240	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
H5A30_RS00245	COG3454	Phosphonate metabolism
H5A30_RS00250	COG4778	phosphonate C-P lyase system protein PhnL
H5A30_RS00255	COG4107	phosphonate C-P lyase system protein PhnK
H5A30_RS00260	COG3627	carbon phosphorus lyase activity
H5A30_RS00265	COG3626	phosphonate metabolism
H5A30_RS00270	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
H5A30_RS00275	COG3624	Phosphonate C-P lyase system protein PhnG
H5A30_RS00285	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
H5A30_RS00285	COG0028	Belongs to the TPP enzyme family
H5A30_RS00300	COG3321	synthase
H5A30_RS00300	COG0300	oxidoreductase activity
H5A30_RS00300	COG0318	PFAM AMP-dependent synthetase and ligase
H5A30_RS00300	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H5A30_RS00300	COG1028	Short-chain dehydrogenase reductase Sdr
H5A30_RS00310	COG1028	Short-chain dehydrogenase reductase Sdr
H5A30_RS00315	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H5A30_RS00320	COG1535	isochorismatase
H5A30_RS00320	COG3433	isochorismatase activity
H5A30_RS00325	COG1021	2,3-dihydroxybenzoate-AMP ligase
H5A30_RS00330	COG1169	isochorismate synthase
H5A30_RS00340	COG4771	TonB-dependent receptor
H5A30_RS00350	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H5A30_RS00355	COG0084	hydrolase, TatD family'
H5A30_RS00365	COG5487	UPF0391 membrane protein
H5A30_RS00370	COG2823	Periplasmic or secreted lipoprotein
H5A30_RS00375	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H5A30_RS00385	COG3726	membrane protein affecting hemolysin expression
H5A30_RS00390	COG0560	Phosphoserine phosphatase
H5A30_RS00405	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H5A30_RS00415	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
H5A30_RS00420	COG3079	Belongs to the UPF0149 family
H5A30_RS00425	COG0006	proline dipeptidase activity
H5A30_RS00430	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H5A30_RS00435	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H5A30_RS00440	COG3157	Type VI secretion system effector, Hcp
H5A30_RS00470	COG2130	NADP-dependent
H5A30_RS00475	COG2862	Uncharacterized protein family, UPF0114
H5A30_RS00495	COG3477	response to acidic pH
H5A30_RS00500	COG0747	negative chemotaxis
H5A30_RS00505	COG0601	transmembrane transport
H5A30_RS00510	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H5A30_RS00530	COG4977	sequence-specific DNA binding
H5A30_RS00530	COG1917	Cupin 2, conserved barrel domain protein
H5A30_RS00535	COG2169	Transcriptional regulator
H5A30_RS00535	COG1917	Cupin 2, conserved barrel domain protein
H5A30_RS00540	COG1070	Carbohydrate kinase
H5A30_RS00545	COG4806	L-rhamnose isomerase
H5A30_RS00550	COG0235	Class ii aldolase
H5A30_RS00555	COG3254	rhamnose metabolic process
H5A30_RS00560	COG0840	transmembrane signaling receptor activity
H5A30_RS00570	COG0840	transmembrane signaling receptor activity
H5A30_RS00575	COG0288	reversible hydration of carbon dioxide
H5A30_RS00580	COG0659	secondary active sulfate transmembrane transporter activity
H5A30_RS00610	COG3541	Predicted nucleotidyltransferase
H5A30_RS00615	COG1690	Belongs to the RtcB family
H5A30_RS00620	COG4650	regulator
H5A30_RS00640	COG0583	DNA-binding transcription factor activity
H5A30_RS00655	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H5A30_RS00675	COG2850	peptidyl-arginine hydroxylation
H5A30_RS00680	COG2304	oxidoreductase activity
H5A30_RS00710	COG1136	(ABC) transporter
H5A30_RS00720	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H5A30_RS00735	COG0529	Catalyzes the synthesis of activated sulfate
H5A30_RS00735	COG2046	Belongs to the sulfate adenylyltransferase family
H5A30_RS00765	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
H5A30_RS00780	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
H5A30_RS00810	COG0795	lipopolysaccharide-transporting ATPase activity
H5A30_RS00815	COG0795	lipopolysaccharide-transporting ATPase activity
H5A30_RS00820	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H5A30_RS00825	COG2927	DNA polymerase III (CHI subunit)
H5A30_RS00830	COG0525	valine-tRNA ligase activity
H5A30_RS00835	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
H5A30_RS00840	COG0840	transmembrane signaling receptor activity
H5A30_RS00845	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H5A30_RS00850	COG0501	Belongs to the peptidase M48B family
H5A30_RS00870	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H5A30_RS00875	COG2731	YhcH YjgK YiaL family protein
H5A30_RS00880	COG0540	Belongs to the ATCase OTCase family
H5A30_RS00885	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
H5A30_RS00905	COG0702	epimerase
H5A30_RS00910	COG3787	Belongs to the UPF0306 family
H5A30_RS00920	COG2814	Major facilitator Superfamily
H5A30_RS00925	COG0076	glutamate decarboxylase activity
H5A30_RS00975	COG0848	biopolymer transport protein
H5A30_RS00985	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H5A30_RS01000	COG0626	cystathionine gamma-synthase activity
H5A30_RS01005	COG0586	Pfam SNARE associated Golgi protein
H5A30_RS01010	COG2207	Transcriptional regulator
H5A30_RS01015	COG0778	Nitroreductase
H5A30_RS01020	COG1979	alcohol dehydrogenase
H5A30_RS01025	COG0656	L-ascorbic acid biosynthetic process
H5A30_RS01035	COG2132	Multicopper oxidase
H5A30_RS01040	COG0204	Acyl-transferase
H5A30_RS01045	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H5A30_RS01065	COG4771	TonB-dependent receptor
H5A30_RS01065	COG1629	transport
H5A30_RS01070	COG3711	transcriptional antiterminator
H5A30_RS01075	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H5A30_RS01075	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H5A30_RS01075	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H5A30_RS01080	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H5A30_RS01085	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H5A30_RS01085	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H5A30_RS01100	COG2249	NAD(P)H dehydrogenase (quinone) activity
H5A30_RS01105	COG0583	DNA-binding transcription factor activity
H5A30_RS01120	COG0187	DNA topoisomerase II activity
H5A30_RS01125	COG3150	esterase
H5A30_RS01130	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H5A30_RS01135	COG3151	Protein conserved in bacteria
H5A30_RS01140	COG0494	nUDIX hydrolase
H5A30_RS01150	COG5463	Belongs to the UPF0441 family
H5A30_RS01155	COG0754	glutathionylspermidine amidase activity
H5A30_RS01160	COG3384	dioxygenase
H5A30_RS01180	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
H5A30_RS01185	COG3107	peptidoglycan biosynthetic process
H5A30_RS01190	COG0792	nuclease activity
H5A30_RS01195	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
H5A30_RS01200	COG2823	Periplasmic or secreted lipoprotein
H5A30_RS01210	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H5A30_RS01215	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
H5A30_RS01220	COG0784	Response regulator, receiver
H5A30_RS01220	COG2198	Histidine kinase
H5A30_RS01220	COG5002	protein histidine kinase activity
H5A30_RS01225	COG1242	4 iron, 4 sulfur cluster binding
H5A30_RS01230	COG0067	glutamate synthase
H5A30_RS01230	COG0070	glutamate synthase
H5A30_RS01230	COG0069	glutamate synthase activity
H5A30_RS01235	COG0493	'glutamate synthase
H5A30_RS01250	COG2969	positive regulation of protein catabolic process
H5A30_RS01255	COG0625	glutathione transferase activity
H5A30_RS01260	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H5A30_RS01265	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H5A30_RS01270	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H5A30_RS01275	COG3105	Protein conserved in bacteria
H5A30_RS01280	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H5A30_RS01285	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H5A30_RS01290	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H5A30_RS01295	COG5007	Belongs to the BolA IbaG family
H5A30_RS01300	COG3113	response to antibiotic
H5A30_RS01305	COG2854	intermembrane phospholipid transfer
H5A30_RS01310	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H5A30_RS01315	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H5A30_RS01320	COG1127	ABC transporter
H5A30_RS01325	COG0530	calcium, potassium:sodium antiporter activity
H5A30_RS01330	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H5A30_RS01330	COG0517	IMP dehydrogenase activity
H5A30_RS01335	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
H5A30_RS01340	COG3117	lipopolysaccharide transmembrane transporter activity
H5A30_RS01345	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
H5A30_RS01350	COG1137	ATPase activity
H5A30_RS01355	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
H5A30_RS01360	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H5A30_RS01365	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H5A30_RS01370	COG1660	Displays ATPase and GTPase activities
H5A30_RS01375	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H5A30_RS01380	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H5A30_RS01385	COG0312	modulator of DNA gyrase
H5A30_RS01390	COG3028	Belongs to the UPF0307 family
H5A30_RS01400	COG1289	transmembrane transporter activity
H5A30_RS01405	COG1566	PFAM secretion protein HlyD family protein
H5A30_RS01415	COG0583	DNA-binding transcription factor activity
H5A30_RS01430	COG0312	modulator of DNA gyrase
H5A30_RS01435	COG3164	Protein of unknown function
H5A30_RS01440	COG1530	ribonuclease E activity
H5A30_RS01445	COG0424	maF-like protein
H5A30_RS01450	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
H5A30_RS01455	COG1792	Involved in formation and maintenance of cell shape
H5A30_RS01460	COG1077	Cell shape determining protein MreB Mrl
H5A30_RS01470	COG2199	diguanylate cyclase activity
H5A30_RS01470	COG2200	EAL domain
H5A30_RS01475	COG0604	alcohol dehydrogenase
H5A30_RS01480	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H5A30_RS01485	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
H5A30_RS01490	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H5A30_RS01495	COG0511	ligase activity, forming carbon-carbon bonds
H5A30_RS01500	COG0439	Biotin carboxylase
H5A30_RS01505	COG2207	Transcriptional regulator
H5A30_RS01510	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H5A30_RS01520	COG3924	membrane
H5A30_RS01525	COG4145	pantothenate transmembrane transporter activity
H5A30_RS01530	COG2264	protein methyltransferase activity
H5A30_RS01545	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
H5A30_RS01565	COG3935	DnaD domain protein
H5A30_RS01585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H5A30_RS01590	COG0765	amino acid transport
H5A30_RS01595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H5A30_RS01600	COG4597	amino acid ABC transporter
H5A30_RS01605	COG0765	amino acid transport
H5A30_RS01610	COG1126	abc transporter atp-binding protein
H5A30_RS01640	COG0138	bifunctional purine biosynthesis protein purh
H5A30_RS01645	COG0151	Belongs to the GarS family
H5A30_RS01665	COG1515	deoxyribonuclease V activity
H5A30_RS01670	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
H5A30_RS01675	COG2816	NAD+ diphosphatase activity
H5A30_RS01680	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
H5A30_RS01685	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
H5A30_RS01690	COG0352	thiamine-phosphate diphosphorylase activity
H5A30_RS01695	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H5A30_RS01700	COG2104	thiamine diphosphate biosynthetic process
H5A30_RS01705	COG2022	thiamine diphosphate biosynthetic process
H5A30_RS01715	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H5A30_RS01720	COG5457	Domain of unknown function (DUF1127)
H5A30_RS01725	COG0477	Major facilitator Superfamily
H5A30_RS01730	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H5A30_RS01735	COG0085	RNA polymerase activity
H5A30_RS01740	COG0222	ribosome binding
H5A30_RS01745	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H5A30_RS01750	COG0081	regulation of translation
H5A30_RS01755	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H5A30_RS01760	COG0250	Participates in transcription elongation, termination and antitermination
H5A30_RS01800	COG1072	(Pantothenic acid kinase))
H5A30_RS01805	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
H5A30_RS01805	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
H5A30_RS01810	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H5A30_RS01845	COG1739	Uncharacterized protein family UPF0029
H5A30_RS01850	COG0006	proline dipeptidase activity
H5A30_RS01855	COG1024	Enoyl-CoA hydratase
H5A30_RS01855	COG1250	3-hydroxyacyl-CoA dehydrogenase
H5A30_RS01860	COG0183	Belongs to the thiolase family
H5A30_RS01870	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
H5A30_RS01875	COG0250	Participates in transcription elongation, termination and antitermination
H5A30_RS01885	COG0084	hydrolase, TatD family'
H5A30_RS01890	COG0805	protein transport
H5A30_RS01895	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H5A30_RS01900	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H5A30_RS01905	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H5A30_RS01915	COG2226	methyltransferase
H5A30_RS01920	COG1322	Protein conserved in bacteria
H5A30_RS01925	COG0165	Argininosuccinate lyase
H5A30_RS01930	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H5A30_RS01935	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H5A30_RS01940	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H5A30_RS01945	COG2188	Transcriptional regulator
H5A30_RS01950	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H5A30_RS01955	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H5A30_RS01980	COG4948	Mandelate Racemase Muconate Lactonizing
H5A30_RS01985	COG1263	PTS System
H5A30_RS01985	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H5A30_RS01985	COG2190	(PTS) system
H5A30_RS01990	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
H5A30_RS02005	COG0412	Dienelactone hydrolase
H5A30_RS02010	COG0840	transmembrane signaling receptor activity
H5A30_RS02015	COG0840	transmembrane signaling receptor activity
H5A30_RS02020	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
H5A30_RS02025	COG0583	DNA-binding transcription factor activity
H5A30_RS02045	COG3157	Type VI secretion system effector, Hcp
H5A30_RS02055	COG1045	serine acetyltransferase
H5A30_RS02060	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H5A30_RS02065	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
H5A30_RS02070	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H5A30_RS02075	COG4942	peptidase
H5A30_RS02080	COG2861	carbohydrate metabolic process
H5A30_RS02085	COG1063	alcohol dehydrogenase
H5A30_RS02090	COG0156	8-amino-7-oxononanoate synthase activity
H5A30_RS02095	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H5A30_RS02105	COG0859	PFAM glycosyl transferase family 9
H5A30_RS02110	COG0859	PFAM glycosyl transferase family 9
H5A30_RS02125	COG1519	Transferase
H5A30_RS02130	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H5A30_RS02135	COG0859	PFAM glycosyl transferase family 9
H5A30_RS02140	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H5A30_RS02150	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H5A30_RS02155	COG2003	Belongs to the UPF0758 family
H5A30_RS02160	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H5A30_RS02165	COG0756	dUTP diphosphatase activity
H5A30_RS02170	COG1309	transcriptional regulator
H5A30_RS02175	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H5A30_RS02180	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
H5A30_RS02185	COG4948	Mandelate Racemase Muconate Lactonizing
H5A30_RS02190	COG4172	Belongs to the ABC transporter superfamily
H5A30_RS02195	COG0747	negative chemotaxis
H5A30_RS02200	COG0601	transmembrane transport
H5A30_RS02205	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H5A30_RS02220	COG1446	asparaginase
H5A30_RS02225	COG0583	DNA-binding transcription factor activity
H5A30_RS02230	COG1561	YicC-like family, N-terminal region
H5A30_RS02270	COG1396	sequence-specific DNA binding
H5A30_RS02295	COG3157	Type VI secretion system effector, Hcp
H5A30_RS02340	COG0628	permease
H5A30_RS02345	COG1304	FMN binding
H5A30_RS02350	COG1012	belongs to the aldehyde dehydrogenase family
H5A30_RS02360	COG3239	Fatty acid desaturase
H5A30_RS02390	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H5A30_RS02395	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H5A30_RS02400	COG3136	membrane protein required for alginate biosynthesis
H5A30_RS02425	COG4677	pectinesterase activity
H5A30_RS02430	COG2771	luxR family
H5A30_RS02440	COG0137	argininosuccinate synthase activity
H5A30_RS02450	COG1609	Transcriptional regulator
H5A30_RS02450	COG2207	Transcriptional regulator
H5A30_RS02455	COG4214	carbohydrate transport
H5A30_RS02460	COG1129	ABC transporter
H5A30_RS02465	COG4213	ABC transporter substrate-binding protein
H5A30_RS02470	COG2115	Belongs to the xylose isomerase family
H5A30_RS02475	COG1070	Carbohydrate kinase
H5A30_RS02480	COG3274	enterobacterial common antigen metabolic process
H5A30_RS02485	COG1012	belongs to the aldehyde dehydrogenase family
H5A30_RS02490	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H5A30_RS02495	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H5A30_RS02500	COG0840	transmembrane signaling receptor activity
H5A30_RS02510	COG3722	fumarate hydratase activity
H5A30_RS02515	COG0246	Mannitol dehydrogenase
H5A30_RS02520	COG2213	PTS system mannitol-specific
H5A30_RS02520	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H5A30_RS02530	COG0751	glycine-tRNA ligase activity
H5A30_RS02535	COG0752	glycyl-tRNA synthetase alpha subunit
H5A30_RS02540	COG0730	response to heat
H5A30_RS02545	COG2818	Glycosylase
H5A30_RS02550	COG0456	acetyltransferase
H5A30_RS02555	COG0840	transmembrane signaling receptor activity
H5A30_RS02560	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H5A30_RS02575	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H5A30_RS02580	COG4172	Belongs to the ABC transporter superfamily
H5A30_RS02585	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H5A30_RS02595	COG3479	Phenolic acid decarboxylase
H5A30_RS02610	COG3550	peptidyl-serine autophosphorylation
H5A30_RS02615	COG3550	peptidyl-serine autophosphorylation
H5A30_RS02620	COG1280	lysine exporter protein (LysE YggA)
H5A30_RS02625	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H5A30_RS02645	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H5A30_RS02650	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H5A30_RS02670	COG2214	Heat shock protein DnaJ domain protein
H5A30_RS02675	COG0443	Heat shock 70 kDa protein
H5A30_RS02690	COG3712	iron ion homeostasis
H5A30_RS02695	COG1595	DNA-templated transcription, initiation
H5A30_RS02700	COG1629	transport
H5A30_RS02710	COG0742	ribosomal rna small subunit methyltransferase
H5A30_RS02715	COG0737	Belongs to the 5'-nucleotidase family
H5A30_RS02725	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H5A30_RS02730	COG0589	response to stress
H5A30_RS02740	COG0306	phosphate transporter
H5A30_RS02745	COG2081	HI0933 family
H5A30_RS02750	COG2200	EAL domain
H5A30_RS02765	COG2194	sulfuric ester hydrolase activity
H5A30_RS02770	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H5A30_RS02775	COG0194	GDP metabolic process
H5A30_RS02780	COG1758	RNA polymerase activity
H5A30_RS02785	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H5A30_RS02790	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H5A30_RS02795	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H5A30_RS02800	COG2233	PERMEase
H5A30_RS02805	COG2982	Protein involved in outer membrane biogenesis
H5A30_RS02810	COG0456	acetyltransferase
H5A30_RS02815	COG1490	D-aminoacyl-tRNA deacylase activity
H5A30_RS02820	COG1011	Hydrolase
H5A30_RS02835	COG3852	Histidine kinase
H5A30_RS02855	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H5A30_RS02865	COG3078	GTPase activator activity
H5A30_RS02870	COG0218	Necessary for normal cell division and for the maintenance of normal septation
H5A30_RS02875	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H5A30_RS02875	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H5A30_RS02885	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H5A30_RS02890	COG3084	Protein conserved in bacteria
H5A30_RS02895	COG0746	molybdenum cofactor guanylyltransferase activity
H5A30_RS02900	COG1763	Mo-molybdopterin cofactor biosynthetic process
H5A30_RS02925	COG1609	Transcriptional regulator
H5A30_RS02930	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H5A30_RS02940	COG1172	Belongs to the binding-protein-dependent transport system permease family
H5A30_RS02945	COG1129	ABC transporter
H5A30_RS02950	COG1869	D-ribose catabolic process
H5A30_RS02955	COG3111	PFAM Bacterial OB fold (BOF) protein
H5A30_RS02965	COG0642	Histidine kinase
H5A30_RS02970	COG3158	transport of potassium into the cell
H5A30_RS02975	COG0714	Associated with various cellular activities
H5A30_RS02980	COG2425	protein containing a von Willebrand factor type A (vWA) domain
H5A30_RS02985	COG2502	aspartate--ammonia ligase
H5A30_RS02990	COG1522	sequence-specific DNA binding
H5A30_RS02995	COG0716	FMN binding
H5A30_RS03000	COG0445	tRNA wobble uridine modification
H5A30_RS03005	COG0357	Ribosomal RNA small subunit methyltransferase G
H5A30_RS03010	COG3312	ion transport
H5A30_RS03015	COG0356	it plays a direct role in the translocation of protons across the membrane
H5A30_RS03025	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H5A30_RS03030	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H5A30_RS03035	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H5A30_RS03040	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H5A30_RS03045	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H5A30_RS03050	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H5A30_RS03055	COG3385	transposase activity
H5A30_RS03065	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H5A30_RS03070	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H5A30_RS03095	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H5A30_RS03100	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H5A30_RS03110	COG0318	PFAM AMP-dependent synthetase and ligase
H5A30_RS03115	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H5A30_RS03115	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
H5A30_RS03120	COG1216	Glycosyl transferase, family 2
H5A30_RS03155	COG1028	Short-chain dehydrogenase reductase Sdr
H5A30_RS03170	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H5A30_RS03175	COG0573	inorganic phosphate transmembrane transporter activity
H5A30_RS03180	COG0581	inorganic phosphate transmembrane transporter activity
H5A30_RS03185	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H5A30_RS03195	COG1396	sequence-specific DNA binding
H5A30_RS03200	COG3135	benzoate transporter
H5A30_RS03205	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H5A30_RS03210	COG0765	amino acid transport
H5A30_RS03215	COG0765	amino acid transport
H5A30_RS03220	COG3547	Transposase (IS116 IS110 IS902 family)
H5A30_RS03225	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H5A30_RS03230	COG2252	PERMEase
H5A30_RS03235	COG2091	lysine biosynthetic process via aminoadipic acid
H5A30_RS03240	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
H5A30_RS03245	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
H5A30_RS03245	COG0493	'glutamate synthase
H5A30_RS03275	COG1733	regulation of RNA biosynthetic process
H5A30_RS03280	COG0702	epimerase
H5A30_RS03290	COG1396	sequence-specific DNA binding
H5A30_RS03295	COG3550	peptidyl-serine autophosphorylation
H5A30_RS03300	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H5A30_RS03305	COG0706	membrane insertase activity
H5A30_RS03315	COG0594	ribonuclease P activity
H5A30_RS03320	COG0230	Belongs to the bacterial ribosomal protein bL34 family
H5A30_RS03325	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H5A30_RS03330	COG0592	DNA-directed DNA polymerase activity
H5A30_RS03335	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H5A30_RS03355	COG0840	transmembrane signaling receptor activity
H5A30_RS03360	COG1609	Transcriptional regulator
H5A30_RS03365	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H5A30_RS03370	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H5A30_RS03375	COG1447	Phosphotransferase system cellobiose-specific component IIA
H5A30_RS03380	COG2723	6-phospho-beta-galactosidase activity
H5A30_RS03385	COG0561	phosphatase activity
H5A30_RS03395	COG0747	negative chemotaxis
H5A30_RS03400	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H5A30_RS03415	COG0601	transmembrane transport
H5A30_RS03420	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H5A30_RS03435	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
H5A30_RS03440	COG2186	Transcriptional regulator
H5A30_RS03445	COG3734	2-keto-3-deoxy-galactonokinase
H5A30_RS03450	COG0800	Aldolase
H5A30_RS03455	COG4948	Mandelate Racemase Muconate Lactonizing
H5A30_RS03460	COG2271	Major facilitator Superfamily
H5A30_RS03470	COG1116	anion transmembrane transporter activity
H5A30_RS03475	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H5A30_RS03480	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H5A30_RS03485	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H5A30_RS03500	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H5A30_RS03500	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H5A30_RS03505	COG2723	6-phospho-beta-galactosidase activity
H5A30_RS03515	COG0823	Involved in the tonB-independent uptake of proteins
H5A30_RS03520	COG5645	(Lipo)protein
H5A30_RS03525	COG0071	Belongs to the small heat shock protein (HSP20) family
H5A30_RS03530	COG0071	Belongs to the small heat shock protein (HSP20) family
H5A30_RS03535	COG0569	domain protein
H5A30_RS03535	COG2985	domain, Protein
H5A30_RS03540	COG0471	metal ion transport
H5A30_RS03545	COG3290	protein histidine kinase activity
H5A30_RS03550	COG4565	transcriptional regulatory protein
H5A30_RS03585	COG3493	citrate carrier protein
H5A30_RS03595	COG0747	negative chemotaxis
H5A30_RS03600	COG0601	transmembrane transport
H5A30_RS03605	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H5A30_RS03610	COG0444	Belongs to the ABC transporter superfamily
H5A30_RS03615	COG4608	Belongs to the ABC transporter superfamily
H5A30_RS03640	COG3501	Rhs element vgr protein
H5A30_RS03650	COG3977	Valine--pyruvate aminotransferase
H5A30_RS03675	COG3210	domain, Protein
H5A30_RS03680	COG2831	hemolysin activation secretion protein
H5A30_RS03685	COG3118	belongs to the thioredoxin family
H5A30_RS03685	COG0457	Tetratricopeptide repeat
H5A30_RS03690	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
H5A30_RS03700	COG1215	transferase activity, transferring glycosyl groups
H5A30_RS03705	COG1192	Involved in chromosome partitioning
H5A30_RS03725	COG2194	sulfuric ester hydrolase activity
H5A30_RS03730	COG2199	diguanylate cyclase activity
H5A30_RS03730	COG2200	EAL domain
H5A30_RS03735	COG1301	dicarboxylic acid transport
H5A30_RS03740	COG0612	Peptidase, M16
H5A30_RS03745	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H5A30_RS03750	COG1295	ribonuclease BN
H5A30_RS03755	COG0477	Major facilitator Superfamily
H5A30_RS03765	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
H5A30_RS03770	COG0425	Belongs to the sulfur carrier protein TusA family
H5A30_RS03780	COG3714	YhhN family
H5A30_RS03790	COG3776	membrane
H5A30_RS03795	COG0742	ribosomal rna small subunit methyltransferase
H5A30_RS03800	COG0552	protein localization to endoplasmic reticulum
H5A30_RS03805	COG2884	Cell division ATP-binding protein ftsE
H5A30_RS03810	COG2177	Part of the ABC transporter FtsEX involved in
H5A30_RS03825	COG0683	leucine binding
H5A30_RS03830	COG0559	Belongs to the binding-protein-dependent transport system permease family
H5A30_RS03835	COG4177	L-phenylalanine transmembrane transporter activity
H5A30_RS03840	COG0411	ABC transporter
H5A30_RS03845	COG0410	ABC transporter
H5A30_RS03850	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H5A30_RS03860	COG0840	transmembrane signaling receptor activity
H5A30_RS03865	COG0840	transmembrane signaling receptor activity
H5A30_RS03870	COG0840	transmembrane signaling receptor activity
H5A30_RS03875	COG2610	gluconate transmembrane transporter activity
H5A30_RS03880	COG3622	Belongs to the hyi family
H5A30_RS03885	COG0235	Class ii aldolase
H5A30_RS03890	COG3395	kinase activity
H5A30_RS03895	COG2084	Dehydrogenase
H5A30_RS03900	COG1349	DNA-binding transcription factor activity
H5A30_RS03935	COG1653	transport
H5A30_RS03940	COG1175	transmembrane transport
H5A30_RS03945	COG0395	ABC-type sugar transport system, permease component
H5A30_RS03950	COG3842	ATPase activity
H5A30_RS03955	COG0584	glycerophosphoryl diester phosphodiesterase
H5A30_RS03970	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H5A30_RS03985	COG2205	protein histidine kinase activity
H5A30_RS03990	COG0745	RESPONSE REGULATOR receiver
H5A30_RS03995	COG3678	ATP-independent chaperone mediated protein folding
H5A30_RS04010	COG2814	Major facilitator Superfamily
H5A30_RS04015	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
H5A30_RS04020	COG0205	6-phosphofructokinase activity
H5A30_RS04025	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H5A30_RS04030	COG2957	Belongs to the agmatine deiminase family
H5A30_RS04045	COG0149	triose-phosphate isomerase activity
H5A30_RS04055	COG3152	Membrane
H5A30_RS04065	COG1494	fructose-1,6-bisphosphatase
H5A30_RS04075	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H5A30_RS04080	COG3074	FtsZ-dependent cytokinesis
H5A30_RS04085	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H5A30_RS04090	COG1575	Belongs to the MenA family. Type 1 subfamily
H5A30_RS04095	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
H5A30_RS04100	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
H5A30_RS04105	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H5A30_RS04110	COG1609	Transcriptional regulator
H5A30_RS04115	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H5A30_RS04120	COG0254	rRNA binding
H5A30_RS04125	COG1598	PFAM Uncharacterised protein family UPF0150
H5A30_RS04135	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H5A30_RS04145	COG1120	ATPase activity
H5A30_RS04150	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
H5A30_RS04155	COG0626	cystathionine gamma-synthase activity
H5A30_RS04160	COG0527	aspartate kinase activity
H5A30_RS04160	COG0460	homoserine dehydrogenase
H5A30_RS04165	COG3842	ATPase activity
H5A30_RS04180	COG0395	ABC-type sugar transport system, permease component
H5A30_RS04185	COG1609	Transcriptional regulator
H5A30_RS04190	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H5A30_RS04205	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H5A30_RS04220	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H5A30_RS04225	COG4206	TonB-dependent receptor
H5A30_RS04230	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H5A30_RS04270	COG1879	ABC-type sugar transport system periplasmic component
H5A30_RS04275	COG1129	ABC transporter
H5A30_RS04280	COG1172	Belongs to the binding-protein-dependent transport system permease family
H5A30_RS04285	COG1172	Belongs to the binding-protein-dependent transport system permease family
H5A30_RS04290	COG0583	DNA-binding transcription factor activity
H5A30_RS04295	COG3085	chromosome segregation
H5A30_RS04315	COG3978	acetolactate synthase activity
H5A30_RS04325	COG0129	dihydroxy-acid dehydratase activity
H5A30_RS04345	COG0583	DNA-binding transcription factor activity
H5A30_RS04350	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H5A30_RS04360	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
H5A30_RS04360	COG0506	proline dehydrogenase activity
H5A30_RS04360	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
H5A30_RS04365	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H5A30_RS04370	COG0210	DNA helicase
H5A30_RS04375	COG0248	Ppx GppA phosphatase
H5A30_RS04380	COG0513	Belongs to the DEAD box helicase family
H5A30_RS04385	COG3118	belongs to the thioredoxin family
H5A30_RS04390	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
H5A30_RS04395	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H5A30_RS04400	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
H5A30_RS04405	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
H5A30_RS04410	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
H5A30_RS04415	COG1088	dTDP-glucose 4,6-dehydratase activity
H5A30_RS04420	COG0456	acetyltransferase
H5A30_RS04425	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H5A30_RS04430	COG2244	polysaccharide biosynthetic process
H5A30_RS04435	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H5A30_RS04445	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
H5A30_RS04480	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H5A30_RS04485	COG0456	acetyltransferase
H5A30_RS04490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H5A30_RS04495	COG0765	amino acid transport
H5A30_RS04500	COG1126	abc transporter atp-binding protein
H5A30_RS04505	COG1473	amidohydrolase
H5A30_RS04510	COG3071	HemY protein
H5A30_RS04515	COG2959	enzyme of heme biosynthesis
H5A30_RS04520	COG1587	Uroporphyrinogen-III synthase
H5A30_RS04525	COG0181	hydroxymethylbilane synthase activity
H5A30_RS04535	COG2814	Major facilitator Superfamily
H5A30_RS04540	COG1965	Belongs to the frataxin family
H5A30_RS04550	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H5A30_RS04565	COG1011	Hydrolase
H5A30_RS04570	COG0210	DNA helicase
H5A30_RS04575	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
H5A30_RS04580	COG0598	Magnesium transport protein CorA
H5A30_RS04585	COG3180	Ammonia monooxygenase
H5A30_RS04595	COG2050	protein possibly involved in aromatic compounds catabolism
H5A30_RS04605	COG0514	ATP-dependent DNA helicase (RecQ)
H5A30_RS04610	COG1280	lysine exporter protein (LysE YggA)
H5A30_RS04615	COG1280	lysine exporter protein (LysE YggA)
H5A30_RS04620	COG2267	carboxylic ester hydrolase activity
H5A30_RS04625	COG0561	phosphatase activity
H5A30_RS04630	COG0584	glycerophosphoryl diester phosphodiesterase
H5A30_RS04635	COG2271	Major facilitator Superfamily
H5A30_RS04640	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
H5A30_RS04645	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
H5A30_RS04650	COG0247	lactate metabolic process
H5A30_RS04660	COG1741	Belongs to the pirin family
H5A30_RS04665	COG1609	Transcriptional regulator
H5A30_RS04670	COG3265	gluconokinase activity
H5A30_RS04675	COG2610	gluconate transmembrane transporter activity
H5A30_RS04680	COG2095	MarC family integral membrane protein
H5A30_RS04685	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H5A30_RS04695	COG3275	phosphorelay sensor kinase activity
H5A30_RS04700	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H5A30_RS04705	COG1523	belongs to the glycosyl hydrolase 13 family
H5A30_RS04710	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H5A30_RS04715	COG0297	glycogen (starch) synthase activity
H5A30_RS04720	COG0058	SHG alpha-glucan phosphorylase activity
H5A30_RS04725	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
H5A30_RS04730	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H5A30_RS04735	COG0705	Rhomboid family
H5A30_RS04740	COG1349	DNA-binding transcription factor activity
H5A30_RS04745	COG0058	SHG alpha-glucan phosphorylase activity
H5A30_RS04750	COG1640	4-alpha-glucanotransferase
H5A30_RS04755	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
H5A30_RS04755	COG0316	Belongs to the HesB IscA family
H5A30_RS04760	COG1040	competence protein
H5A30_RS04765	COG2267	carboxylic ester hydrolase activity
H5A30_RS04770	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H5A30_RS04785	COG1785	Belongs to the alkaline phosphatase family
H5A30_RS04815	COG1414	Transcriptional regulator
H5A30_RS04820	COG2183	response to ionizing radiation
H5A30_RS04830	COG0840	transmembrane signaling receptor activity
H5A30_RS04840	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H5A30_RS04850	COG4264	IucA IucC family
H5A30_RS04855	COG4774	siderophore transport
H5A30_RS04860	COG0019	diaminopimelate decarboxylase activity
H5A30_RS04865	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H5A30_RS04870	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H5A30_RS04875	COG2814	Major facilitator Superfamily
H5A30_RS04900	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
H5A30_RS04905	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
H5A30_RS04910	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
H5A30_RS04915	COG1011	Hydrolase
H5A30_RS04925	COG0494	nUDIX hydrolase
H5A30_RS04935	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
H5A30_RS04960	COG4796	Type ii and iii secretion system protein
H5A30_RS04965	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H5A30_RS04970	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H5A30_RS04985	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H5A30_RS04990	COG0546	phosphoglycolate phosphatase activity
H5A30_RS05000	COG1473	amidohydrolase
H5A30_RS05025	COG1648	precorrin-2 dehydrogenase activity
H5A30_RS05025	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H5A30_RS05035	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H5A30_RS05040	COG4948	Mandelate Racemase Muconate Lactonizing
H5A30_RS05045	COG0747	negative chemotaxis
H5A30_RS05050	COG0601	transmembrane transport
H5A30_RS05055	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H5A30_RS05060	COG0444	Belongs to the ABC transporter superfamily
H5A30_RS05065	COG4608	Belongs to the ABC transporter superfamily
H5A30_RS05070	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H5A30_RS05090	COG3866	Pectate lyase
H5A30_RS05100	COG0582	viral genome integration into host DNA
H5A30_RS05130	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H5A30_RS05135	COG1765	OsmC-like protein
H5A30_RS05140	COG3954	Phosphoribulokinase
H5A30_RS05145	COG3089	Belongs to the UPF0270 family
H5A30_RS05150	COG0429	hydrolase of the alpha beta-hydrolase fold
H5A30_RS05165	COG3853	Toxic anion resistance protein (TelA)
H5A30_RS05170	COG0488	(ABC) transporter
H5A30_RS05175	COG2249	NAD(P)H dehydrogenase (quinone) activity
H5A30_RS05180	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H5A30_RS05180	COG0475	glutathione-regulated potassium exporter activity
H5A30_RS05185	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
H5A30_RS05190	COG1047	Peptidyl-prolyl cis-trans
H5A30_RS05195	COG2900	Belongs to the SlyX family
H5A30_RS05200	COG0545	Peptidyl-prolyl cis-trans isomerase
H5A30_RS05205	COG3385	transposase activity
H5A30_RS05220	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H5A30_RS05225	COG0642	Histidine kinase
H5A30_RS05230	COG0745	RESPONSE REGULATOR receiver
H5A30_RS05240	COG2964	Protein conserved in bacteria
H5A30_RS05245	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
H5A30_RS05250	COG2923	Belongs to the DsrF TusC family
H5A30_RS05255	COG2168	tRNA wobble position uridine thiolation
H5A30_RS05260	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H5A30_RS05265	COG0049	tRNA binding
H5A30_RS05270	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H5A30_RS05285	COG2193	ferroxidase activity
H5A30_RS05290	COG0051	transcription antitermination factor activity, RNA binding
H5A30_RS05295	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H5A30_RS05300	COG0088	Forms part of the polypeptide exit tunnel
H5A30_RS05310	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H5A30_RS05315	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H5A30_RS05320	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H5A30_RS05325	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H5A30_RS05330	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H5A30_RS05335	COG0255	Belongs to the universal ribosomal protein uL29 family
H5A30_RS05340	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H5A30_RS05350	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H5A30_RS05355	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H5A30_RS05360	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H5A30_RS05365	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H5A30_RS05370	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H5A30_RS05375	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H5A30_RS05380	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
H5A30_RS05385	COG1841	ribosomal large subunit assembly
H5A30_RS05390	COG0200	Binds to the 23S rRNA
H5A30_RS05395	COG0201	protein transport
H5A30_RS05400	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H5A30_RS05405	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H5A30_RS05415	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H5A30_RS05420	COG0202	RNA polymerase activity
H5A30_RS05425	COG0203	ribosomal protein L17
H5A30_RS05430	COG3036	rescue of stalled ribosome
H5A30_RS05435	COG1970	mechanosensitive ion channel activity
H5A30_RS05440	COG0569	domain protein
H5A30_RS05445	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H5A30_RS05445	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H5A30_RS05450	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H5A30_RS05455	COG0242	peptide deformylase activity
H5A30_RS05460	COG0758	DNA mediated transformation
H5A30_RS05465	COG2922	Belongs to the Smg family
H5A30_RS05470	COG0551	DNA topoisomerase type I activity
H5A30_RS05475	COG0009	L-threonylcarbamoyladenylate synthase
H5A30_RS05480	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H5A30_RS05490	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H5A30_RS05515	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
H5A30_RS05520	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H5A30_RS05530	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
H5A30_RS05545	COG1410	methionine synthase
H5A30_RS05545	COG0646	methionine synthase
H5A30_RS05550	COG2207	Transcriptional regulator
H5A30_RS05565	COG0471	metal ion transport
H5A30_RS05575	COG0527	aspartate kinase activity
H5A30_RS05580	COG0166	Belongs to the GPI family
H5A30_RS05590	COG1509	lysine 2,3-aminomutase activity
H5A30_RS05595	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H5A30_RS05610	COG3040	lipid binding
H5A30_RS05615	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
H5A30_RS05620	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
H5A30_RS05625	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H5A30_RS05630	COG1053	succinate dehydrogenase
H5A30_RS05635	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
H5A30_RS05640	COG3264	Mechanosensitive ion channel
H5A30_RS05640	COG1511	domain protein
H5A30_RS05645	COG0688	phosphatidylethanolamine metabolic process
H5A30_RS05650	COG1162	GTPase activity
H5A30_RS05655	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
H5A30_RS05695	COG1011	Hydrolase
H5A30_RS05715	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H5A30_RS05720	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
H5A30_RS05740	COG1064	alcohol dehydrogenase
H5A30_RS05745	COG1704	LemA family
H5A30_RS05760	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H5A30_RS05785	COG1136	(ABC) transporter
H5A30_RS05790	COG1136	(ABC) transporter
H5A30_RS05790	COG0577	efflux transmembrane transporter activity
H5A30_RS05815	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
H5A30_RS05830	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H5A30_RS05835	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H5A30_RS05835	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H5A30_RS05840	COG0802	atpase or kinase
H5A30_RS05850	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H5A30_RS05855	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H5A30_RS05860	COG1923	regulation of RNA biosynthetic process
H5A30_RS05865	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H5A30_RS05870	COG0330	HflC and HflK could
H5A30_RS05875	COG0330	HflC and HflK could
H5A30_RS05880	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
H5A30_RS05885	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H5A30_RS05890	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H5A30_RS05895	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
H5A30_RS05900	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H5A30_RS05905	COG1678	Uncharacterized ACR, COG1678
H5A30_RS05910	COG0189	ligase activity
H5A30_RS05915	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H5A30_RS05920	COG2356	endonuclease I
H5A30_RS05925	COG3091	SprT-like family
H5A30_RS05930	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H5A30_RS05940	COG1166	arginine decarboxylase activity
H5A30_RS05950	COG0501	Belongs to the peptidase M48B family
H5A30_RS05955	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H5A30_RS05960	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H5A30_RS05965	COG0126	phosphoglycerate kinase activity
H5A30_RS05970	COG0191	fructose-bisphosphate aldolase activity
H5A30_RS05975	COG0668	transmembrane transport
H5A30_RS05980	COG1279	arginine transmembrane transporter activity
H5A30_RS05990	COG0583	DNA-binding transcription factor activity
H5A30_RS05995	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
H5A30_RS06000	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H5A30_RS06005	COG0604	alcohol dehydrogenase
H5A30_RS06010	COG0583	DNA-binding transcription factor activity
H5A30_RS06015	COG0840	transmembrane signaling receptor activity
H5A30_RS06020	COG0488	(ABC) transporter
H5A30_RS06030	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
H5A30_RS06035	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
H5A30_RS06045	COG3708	Transcriptional regulator
H5A30_RS06045	COG2207	Transcriptional regulator
H5A30_RS06050	COG3045	CreA protein
H5A30_RS06055	COG0745	RESPONSE REGULATOR receiver
H5A30_RS06060	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
H5A30_RS06075	COG0083	homoserine kinase activity
H5A30_RS06085	COG3022	response to hydroperoxide
H5A30_RS06090	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H5A30_RS06100	COG0521	Mo-molybdopterin cofactor biosynthetic process
H5A30_RS06110	COG1584	GPR1 FUN34 yaaH family protein
H5A30_RS06115	COG0443	Heat shock 70 kDa protein
H5A30_RS06120	COG0484	heat shock protein binding
H5A30_RS06125	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H5A30_RS06130	COG0583	DNA-binding transcription factor activity
H5A30_RS06135	COG0268	Binds directly to 16S ribosomal RNA
H5A30_RS06140	COG0196	riboflavin kinase activity
H5A30_RS06145	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H5A30_RS06155	COG1047	Peptidyl-prolyl cis-trans
H5A30_RS06160	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H5A30_RS06165	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H5A30_RS06170	COG0505	Belongs to the CarA family
H5A30_RS06175	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H5A30_RS06185	COG2966	Psort location CytoplasmicMembrane, score
H5A30_RS06190	COG3610	response to peptide
H5A30_RS06195	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H5A30_RS06215	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H5A30_RS06220	COG2967	ApaG domain
H5A30_RS06225	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H5A30_RS06230	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H5A30_RS06235	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H5A30_RS06240	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
H5A30_RS06245	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
H5A30_RS06250	COG0564	pseudouridine synthase activity
H5A30_RS06255	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H5A30_RS06260	COG0417	DNA replication proofreading
H5A30_RS06265	COG3706	GGDEF domain
H5A30_RS06270	COG0586	Pfam SNARE associated Golgi protein
H5A30_RS06275	COG0440	acetolactate synthase activity
H5A30_RS06280	COG0028	Belongs to the TPP enzyme family
H5A30_RS06285	COG3507	Belongs to the glycosyl hydrolase 43 family
H5A30_RS06290	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
H5A30_RS06295	COG1178	ABC-type Fe3 transport system permease component
H5A30_RS06300	COG4143	(ABC) transporter
H5A30_RS06305	COG4533	DNA binding
H5A30_RS06320	COG3033	Beta-eliminating lyase
H5A30_RS06330	COG0840	transmembrane signaling receptor activity
H5A30_RS06350	COG0066	3-isopropylmalate dehydratase activity
H5A30_RS06355	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H5A30_RS06360	COG0473	3-isopropylmalate dehydrogenase activity
H5A30_RS06365	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H5A30_RS06370	COG1022	Amp-dependent synthetase and ligase
H5A30_RS06375	COG0028	Belongs to the TPP enzyme family
H5A30_RS06395	COG2001	Belongs to the MraZ family
H5A30_RS06400	COG0275	rRNA processing
H5A30_RS06405	COG3116	cell division
H5A30_RS06410	COG0768	penicillin binding
H5A30_RS06415	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H5A30_RS06420	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H5A30_RS06425	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H5A30_RS06430	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H5A30_RS06435	COG0772	Belongs to the SEDS family
H5A30_RS06440	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H5A30_RS06445	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H5A30_RS06450	COG1181	Belongs to the D-alanine--D-alanine ligase family
H5A30_RS06455	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H5A30_RS06460	COG0849	cell division
H5A30_RS06465	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H5A30_RS06470	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
H5A30_RS06485	COG0653	protein targeting
H5A30_RS06490	COG0494	nUDIX hydrolase
H5A30_RS06495	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
H5A30_RS06500	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
H5A30_RS06505	COG0237	dephospho-CoA kinase activity
H5A30_RS06510	COG0516	GMP reductase activity
H5A30_RS06515	COG1459	type II secretion system
H5A30_RS06520	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H5A30_RS06525	COG4969	Belongs to the N-Me-Phe pilin family
H5A30_RS06530	COG0157	Belongs to the NadC ModD family
H5A30_RS06535	COG3248	Nucleoside-binding outer membrane protein
H5A30_RS06540	COG3023	N-Acetylmuramoyl-L-alanine amidase
H5A30_RS06545	COG3725	Membrane protein required for beta-lactamase induction
H5A30_RS06550	COG3940	Belongs to the glycosyl hydrolase 43 family
H5A30_RS06555	COG2211	Major facilitator Superfamily
H5A30_RS06560	COG1113	amino acid transport
H5A30_RS06570	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
H5A30_RS06575	COG0508	dehydrogenase complex catalyzes the overall conversion of
H5A30_RS06580	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H5A30_RS06585	COG0583	DNA-binding transcription factor activity
H5A30_RS06605	COG1073	alpha beta
H5A30_RS06615	COG2079	MmgE PrpD family protein
H5A30_RS06620	COG2207	Transcriptional regulator
H5A30_RS06630	COG0640	Transcriptional regulator
H5A30_RS06650	COG3112	Uncharacterised protein family (UPF0231)
H5A30_RS06655	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H5A30_RS06670	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H5A30_RS06675	COG1609	Transcriptional regulator
H5A30_RS06700	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H5A30_RS06705	COG1882	Formate acetyltransferase
H5A30_RS06710	COG1028	Short-chain dehydrogenase reductase Sdr
H5A30_RS06715	COG2731	YhcH YjgK YiaL family protein
H5A30_RS06730	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H5A30_RS06735	COG1454	alcohol dehydrogenase
H5A30_RS06740	COG3395	kinase activity
H5A30_RS06745	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H5A30_RS06750	COG1349	DNA-binding transcription factor activity
H5A30_RS06760	COG0803	Belongs to the bacterial solute-binding protein 9 family
H5A30_RS06765	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H5A30_RS06770	COG1121	(ABC) transporter
H5A30_RS06780	COG2971	BadF BadG BcrA BcrD
H5A30_RS06800	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
H5A30_RS06805	COG3842	ATPase activity
H5A30_RS06810	COG1175	transmembrane transport
H5A30_RS06815	COG0395	ABC-type sugar transport system, permease component
H5A30_RS06835	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H5A30_RS06880	COG3547	Transposase (IS116 IS110 IS902 family)
H5A30_RS06890	COG0629	single-stranded DNA binding
H5A30_RS06900	COG0432	Pfam Uncharacterised protein family UPF0047
H5A30_RS06930	COG1203	CRISPR-associated helicase, Cas3
H5A30_RS06935	COG1518	maintenance of DNA repeat elements
H5A30_RS06965	COG1451	nucleotide metabolic process
H5A30_RS06970	COG1448	Aminotransferase
H5A30_RS06980	COG1522	sequence-specific DNA binding
H5A30_RS07000	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H5A30_RS07015	COG2124	cytochrome p450
H5A30_RS07030	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H5A30_RS07050	COG0583	DNA-binding transcription factor activity
H5A30_RS07055	COG0583	DNA-binding transcription factor activity
H5A30_RS07070	COG1396	sequence-specific DNA binding
H5A30_RS07075	COG1609	Transcriptional regulator
H5A30_RS07080	COG1447	Phosphotransferase system cellobiose-specific component IIA
H5A30_RS07085	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H5A30_RS07090	COG2723	6-phospho-beta-galactosidase activity
H5A30_RS07095	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H5A30_RS07100	COG2186	Transcriptional regulator
H5A30_RS07110	COG0204	Acyl-transferase
H5A30_RS07110	COG0318	PFAM AMP-dependent synthetase and ligase
H5A30_RS07115	COG0477	Major facilitator Superfamily
H5A30_RS07120	COG2153	protein acetylation
H5A30_RS07145	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H5A30_RS07150	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H5A30_RS07155	COG1872	DUF167
H5A30_RS07160	COG0762	integral membrane protein
H5A30_RS07165	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H5A30_RS07170	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H5A30_RS07175	COG2805	Type II/IV secretion system protein
H5A30_RS07185	COG0840	transmembrane signaling receptor activity
H5A30_RS07190	COG1959	2 iron, 2 sulfur cluster binding
H5A30_RS07195	COG0557	exoribonuclease II activity
H5A30_RS07200	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H5A30_RS07205	COG0840	transmembrane signaling receptor activity
H5A30_RS07210	COG3766	membrane
H5A30_RS07230	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
H5A30_RS07235	COG1690	Belongs to the RtcB family
H5A30_RS07240	COG0840	transmembrane signaling receptor activity
H5A30_RS07245	COG1073	alpha beta
H5A30_RS07250	COG0360	Binds together with S18 to 16S ribosomal RNA
H5A30_RS07255	COG2965	DNA replication, synthesis of RNA primer
H5A30_RS07260	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H5A30_RS07265	COG0359	binds to the 23S rRNA
H5A30_RS07275	COG3061	Opacity-associated protein A
H5A30_RS07280	COG0545	Peptidyl-prolyl cis-trans isomerase
H5A30_RS07285	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
H5A30_RS07290	COG3961	Belongs to the TPP enzyme family
H5A30_RS07305	COG1733	regulation of RNA biosynthetic process
H5A30_RS07310	COG0737	Belongs to the 5'-nucleotidase family
H5A30_RS07315	COG1218	3'(2'),5'-bisphosphate nucleotidase
H5A30_RS07320	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
H5A30_RS07330	COG3547	Transposase (IS116 IS110 IS902 family)
H5A30_RS07335	COG1253	flavin adenine dinucleotide binding
H5A30_RS07340	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H5A30_RS07345	COG0729	surface antigen
H5A30_RS07350	COG2911	Protein conserved in bacteria
H5A30_RS07355	COG2105	PFAM AIG2 family protein
H5A30_RS07360	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H5A30_RS07365	COG0840	transmembrane signaling receptor activity
H5A30_RS07370	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
H5A30_RS07375	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
H5A30_RS07380	COG1968	undecaprenyl-diphosphatase activity
H5A30_RS07385	COG0617	tRNA 3'-terminal CCA addition
H5A30_RS07390	COG4991	sh3 domain protein
H5A30_RS07395	COG3025	triphosphatase activity
H5A30_RS07400	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H5A30_RS07405	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
H5A30_RS07405	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
H5A30_RS07410	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H5A30_RS07415	COG3530	Putative quorum-sensing-regulated virulence factor
H5A30_RS07430	COG0840	transmembrane signaling receptor activity
H5A30_RS07435	COG2721	sulfolactate sulfo-lyase activity
H5A30_RS07440	COG2271	Major facilitator Superfamily
H5A30_RS07445	COG4948	Mandelate Racemase Muconate Lactonizing
H5A30_RS07450	COG4948	Mandelate Racemase Muconate Lactonizing
H5A30_RS07460	COG2084	Dehydrogenase
H5A30_RS07465	COG1929	Belongs to the glycerate kinase type-1 family
H5A30_RS07475	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H5A30_RS07480	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H5A30_RS07490	COG3956	TIGRFAM MazG family protein
H5A30_RS07495	COG0504	CTP synthase activity
H5A30_RS07500	COG0148	phosphopyruvate hydratase activity
H5A30_RS07510	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H5A30_RS07525	COG0583	DNA-binding transcription factor activity
H5A30_RS07535	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
H5A30_RS07545	COG1028	Short-chain dehydrogenase reductase Sdr
H5A30_RS07550	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H5A30_RS07555	COG0602	queuosine metabolic process
H5A30_RS07560	COG0720	synthase
H5A30_RS07580	COG2200	EAL domain
H5A30_RS07590	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H5A30_RS07595	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H5A30_RS07600	COG0175	sulfate reduction
H5A30_RS07610	COG0444	Belongs to the ABC transporter superfamily
H5A30_RS07625	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H5A30_RS07630	COG0584	glycerophosphoryl diester phosphodiesterase
H5A30_RS07635	COG1648	precorrin-2 dehydrogenase activity
H5A30_RS07635	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H5A30_RS07640	COG0175	sulfate reduction
H5A30_RS07645	COG2895	sulfate adenylyltransferase (ATP) activity
H5A30_RS07650	COG0529	Catalyzes the synthesis of activated sulfate
H5A30_RS07660	COG1126	abc transporter atp-binding protein
H5A30_RS07665	COG0765	amino acid transport
H5A30_RS07675	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
H5A30_RS07680	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H5A30_RS07685	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
H5A30_RS07690	COG0585	pseudouridine synthase activity
H5A30_RS07695	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H5A30_RS07700	COG4942	peptidase
H5A30_RS07700	COG1388	LysM domain
H5A30_RS07710	COG0442	prolyl-tRNA aminoacylation
H5A30_RS07715	COG1720	tRNA m6t6A37 methyltransferase activity
H5A30_RS07725	COG1464	Belongs to the NlpA lipoprotein family
H5A30_RS07730	COG2011	ABC-type metal ion transport system permease component
H5A30_RS07735	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H5A30_RS07740	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H5A30_RS07775	COG0477	Major facilitator Superfamily
H5A30_RS07780	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H5A30_RS07785	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H5A30_RS07785	COG1042	CoA-binding domain protein
H5A30_RS07785	COG0045	succinate-CoA ligase (ADP-forming) activity
H5A30_RS07790	COG3148	PFAM DTW domain containing protein
H5A30_RS07795	COG3118	belongs to the thioredoxin family
H5A30_RS07800	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H5A30_RS07810	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H5A30_RS07815	COG2814	Major facilitator Superfamily
H5A30_RS07820	COG1566	PFAM secretion protein HlyD family protein
H5A30_RS07825	COG1846	Transcriptional regulator
H5A30_RS07835	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
H5A30_RS07840	COG2814	Major facilitator Superfamily
H5A30_RS07845	COG2706	6-phosphogluconolactonase activity
H5A30_RS07855	COG0596	Alpha beta hydrolase
H5A30_RS07860	COG2113	Glycine betaine
H5A30_RS07865	COG4176	ABC-type proline glycine betaine transport system permease component
H5A30_RS07870	COG4175	Glycine betaine
H5A30_RS07915	COG0765	amino acid transport
H5A30_RS07925	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H5A30_RS07940	COG0436	Aminotransferase
H5A30_RS07945	COG0235	Class ii aldolase
H5A30_RS07950	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
H5A30_RS07955	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
H5A30_RS07960	COG3501	Rhs element vgr protein
H5A30_RS07990	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
H5A30_RS07995	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
H5A30_RS08005	COG1960	acyl-CoA dehydrogenase activity
H5A30_RS08010	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
H5A30_RS08015	COG0121	glutamine amidotransferase
H5A30_RS08020	COG3034	peptidoglycan biosynthetic process
H5A30_RS08025	COG2226	methyltransferase
H5A30_RS08035	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H5A30_RS08040	COG2195	Cleaves the N-terminal amino acid of tripeptides
H5A30_RS08045	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
H5A30_RS08050	COG1073	alpha beta
H5A30_RS08075	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H5A30_RS08080	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
H5A30_RS08170	COG3829	transcription factor binding
H5A30_RS08205	COG3501	Rhs element vgr protein
H5A30_RS08300	COG2999	glutathione oxidoreductase activity
H5A30_RS08310	COG2814	Major facilitator Superfamily
H5A30_RS08335	COG1546	Belongs to the CinA family
H5A30_RS08340	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H5A30_RS08345	COG2137	regulation of response to DNA damage stimulus
H5A30_RS08350	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H5A30_RS08355	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
H5A30_RS08380	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H5A30_RS08385	COG1238	metal cluster binding
H5A30_RS08390	COG2918	glutathione biosynthetic process
H5A30_RS08395	COG1854	S-ribosylhomocysteine lyase activity
H5A30_RS08400	COG4137	Cytochrome C assembly protein
H5A30_RS08405	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H5A30_RS08410	COG0228	four-way junction DNA binding
H5A30_RS08415	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H5A30_RS08420	COG0336	Belongs to the RNA methyltransferase TrmD family
H5A30_RS08425	COG0335	large ribosomal subunit rRNA binding
H5A30_RS08440	COG2264	protein methyltransferase activity
H5A30_RS08450	COG3279	Response regulator of the LytR AlgR family
H5A30_RS08455	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H5A30_RS08460	COG0287	Prephenate dehydrogenase
H5A30_RS08460	COG1605	Chorismate mutase
H5A30_RS08465	COG1605	Chorismate mutase
H5A30_RS08465	COG0077	Prephenate dehydratase
H5A30_RS08470	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H5A30_RS08475	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H5A30_RS08480	COG0564	pseudouridine synthase activity
H5A30_RS08490	COG0542	response to heat
H5A30_RS08525	COG3021	interspecies interaction between organisms
H5A30_RS08530	COG0741	lytic transglycosylase activity
H5A30_RS08530	COG1388	LysM domain
H5A30_RS08535	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H5A30_RS08540	COG2226	methyltransferase
H5A30_RS08545	COG0328	RNA-DNA hybrid ribonuclease activity
H5A30_RS08560	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H5A30_RS08570	COG1780	Probably involved in ribonucleotide reductase function
H5A30_RS08575	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H5A30_RS08580	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
H5A30_RS08585	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
H5A30_RS08600	COG3842	ATPase activity
H5A30_RS08615	COG0288	reversible hydration of carbon dioxide
H5A30_RS08620	COG1131	(ABC) transporter
H5A30_RS08625	COG0842	Transport permease protein
H5A30_RS08630	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
H5A30_RS08635	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H5A30_RS08640	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H5A30_RS08645	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H5A30_RS08655	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H5A30_RS08665	COG1489	DNA binding
H5A30_RS08670	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
H5A30_RS08675	COG1643	Atp-dependent helicase
H5A30_RS08680	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H5A30_RS08685	COG1120	ATPase activity
H5A30_RS08690	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H5A30_RS08695	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H5A30_RS08705	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H5A30_RS08710	COG0625	glutathione transferase activity
H5A30_RS08715	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H5A30_RS08720	COG0316	Belongs to the HesB IscA family
H5A30_RS08730	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H5A30_RS08735	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H5A30_RS08740	COG0232	Belongs to the dGTPase family. Type 2 subfamily
H5A30_RS08745	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H5A30_RS08750	COG3835	regulator
H5A30_RS08755	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H5A30_RS08765	COG4208	sulfate ABC transporter
H5A30_RS08770	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
H5A30_RS08785	COG0667	Aldo Keto reductase
H5A30_RS08790	COG1902	pentaerythritol trinitrate reductase activity
H5A30_RS08815	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H5A30_RS08820	COG2819	hydrolase of the alpha beta superfamily
H5A30_RS08835	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H5A30_RS08840	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
H5A30_RS08845	COG0513	Belongs to the DEAD box helicase family
H5A30_RS08850	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
H5A30_RS08855	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
H5A30_RS08870	COG3026	antisigma factor binding
H5A30_RS08875	COG3086	response to oxidative stress
H5A30_RS08880	COG0481	GTPase activity
H5A30_RS08890	COG0571	ribonuclease III activity
H5A30_RS08895	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H5A30_RS08900	COG1381	Involved in DNA repair and RecF pathway recombination
H5A30_RS08905	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H5A30_RS08910	COG0736	holo-[acyl-carrier-protein] synthase activity
H5A30_RS08915	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H5A30_RS08920	COG2200	EAL domain
H5A30_RS08930	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H5A30_RS08935	COG2274	protein secretion by the type I secretion system
H5A30_RS08955	COG2200	EAL domain
H5A30_RS08955	COG3287	FIST C domain
H5A30_RS08955	COG2199	diguanylate cyclase activity
H5A30_RS08965	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
H5A30_RS08970	COG0560	Phosphoserine phosphatase
H5A30_RS08980	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
H5A30_RS08985	COG0047	phosphoribosylformylglycinamidine synthase activity
H5A30_RS08985	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H5A30_RS08990	COG2205	protein histidine kinase activity
H5A30_RS08995	COG3170	Tfp pilus assembly protein FimV
H5A30_RS09000	COG2204	response regulator
H5A30_RS09005	COG0347	Belongs to the P(II) protein family
H5A30_RS09010	COG4677	pectinesterase activity
H5A30_RS09020	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H5A30_RS09020	COG1017	nitric oxide dioxygenase activity
H5A30_RS09025	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H5A30_RS09030	COG2814	Major facilitator Superfamily
H5A30_RS09035	COG3683	transport system, periplasmic component
H5A30_RS09040	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
H5A30_RS09050	COG0840	transmembrane signaling receptor activity
H5A30_RS09060	COG1120	ATPase activity
H5A30_RS09065	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H5A30_RS09075	COG0483	inositol monophosphate 1-phosphatase activity
H5A30_RS09080	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
H5A30_RS09085	COG1959	2 iron, 2 sulfur cluster binding
H5A30_RS09090	COG1104	cysteine desulfurase activity
H5A30_RS09095	COG0822	iron-sulfur transferase activity
H5A30_RS09100	COG0316	Belongs to the HesB IscA family
H5A30_RS09105	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
H5A30_RS09110	COG0443	Heat shock 70 kDa protein
H5A30_RS09115	COG0633	Ferredoxin
H5A30_RS09120	COG2975	iron-sulfur cluster assembly
H5A30_RS09125	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H5A30_RS09135	COG1737	Transcriptional regulator
H5A30_RS09140	COG2897	thiosulfate sulfurtransferase activity
H5A30_RS09145	COG1486	melibiose metabolic process
H5A30_RS09150	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H5A30_RS09150	COG1263	PTS System
H5A30_RS09150	COG2190	(PTS) system
H5A30_RS09155	COG0105	UTP biosynthetic process
H5A30_RS09160	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H5A30_RS09170	COG1426	Protein conserved in bacteria
H5A30_RS09175	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
H5A30_RS09180	COG0124	histidyl-tRNA synthetase
H5A30_RS09185	COG2976	Protein conserved in bacteria
H5A30_RS09190	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H5A30_RS09195	COG1160	GTP binding
H5A30_RS09210	COG1645	bacterial-type flagellum-dependent swarming motility
H5A30_RS09225	COG1570	exodeoxyribonuclease VII activity
H5A30_RS09230	COG0517	IMP dehydrogenase activity
H5A30_RS09230	COG0516	GMP reductase activity
H5A30_RS09235	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H5A30_RS09235	COG0519	Catalyzes the synthesis of GMP from XMP
H5A30_RS09250	COG3423	Transcriptional regulator
H5A30_RS09275	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H5A30_RS09315	COG3706	GGDEF domain
H5A30_RS09320	COG1064	alcohol dehydrogenase
H5A30_RS09325	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
H5A30_RS09330	COG0351	phosphomethylpyrimidine kinase
H5A30_RS09335	COG3223	Belongs to the PsiE family
H5A30_RS09340	COG1597	lipid kinase activity
H5A30_RS09345	COG0826	peptidase U32
H5A30_RS09350	COG0435	Glutathione S-transferase
H5A30_RS09365	COG0745	RESPONSE REGULATOR receiver
H5A30_RS09370	COG2205	protein histidine kinase activity
H5A30_RS09375	COG0477	Major facilitator Superfamily
H5A30_RS09380	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H5A30_RS09385	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H5A30_RS09390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H5A30_RS09395	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H5A30_RS09410	COG1874	Beta-galactosidase
H5A30_RS09415	COG3867	Arabinogalactan endo-beta-1,4-galactanase
H5A30_RS09420	COG3833	ABC-type maltose transport systems, permease component
H5A30_RS09425	COG1175	transmembrane transport
H5A30_RS09430	COG2182	Extracellular solute-binding protein
H5A30_RS09435	COG3842	ATPase activity
H5A30_RS09440	COG4580	involved in the transport of maltose and maltodextrins
H5A30_RS09445	COG1609	Transcriptional regulator
H5A30_RS09460	COG2239	Acts as a magnesium transporter
H5A30_RS09465	COG1846	Transcriptional regulator
H5A30_RS09470	COG1764	response to oxidative stress
H5A30_RS09490	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
H5A30_RS09495	COG0573	inorganic phosphate transmembrane transporter activity
H5A30_RS09500	COG0581	inorganic phosphate transmembrane transporter activity
H5A30_RS09505	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H5A30_RS09515	COG1760	l-serine dehydratase
H5A30_RS09520	COG0814	amino acid
H5A30_RS09525	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H5A30_RS09530	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
H5A30_RS09535	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H5A30_RS09540	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H5A30_RS09550	COG0215	cysteine-tRNA ligase activity
H5A30_RS09555	COG2501	S4 domain
H5A30_RS09560	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H5A30_RS09565	COG3706	GGDEF domain
H5A30_RS09565	COG4251	negative regulation of phosphorylation
H5A30_RS09565	COG5001	Diguanylate cyclase
H5A30_RS09565	COG2203	Gaf domain
H5A30_RS09570	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
H5A30_RS09575	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H5A30_RS09580	COG0463	Glycosyl transferase, family 2
H5A30_RS09585	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H5A30_RS09585	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H5A30_RS09590	COG0726	polysaccharide deacetylase
H5A30_RS09595	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
H5A30_RS09600	COG2076	Multidrug Resistance protein
H5A30_RS09605	COG2076	Multidrug Resistance protein
H5A30_RS09610	COG3842	ATPase activity
H5A30_RS09625	COG1447	Phosphotransferase system cellobiose-specific component IIA
H5A30_RS09655	COG1696	Membrane protein involved in D-alanine export
H5A30_RS09660	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H5A30_RS09675	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H5A30_RS09705	COG1511	domain protein
H5A30_RS09705	COG3264	Mechanosensitive ion channel
H5A30_RS09715	COG4948	Mandelate Racemase Muconate Lactonizing
H5A30_RS09720	COG0436	Aminotransferase
H5A30_RS09730	COG3266	domain, Protein
H5A30_RS09735	COG3866	Pectate lyase
H5A30_RS09815	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H5A30_RS09820	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H5A30_RS09825	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H5A30_RS09830	COG1120	ATPase activity
H5A30_RS09840	COG0513	Belongs to the DEAD box helicase family
H5A30_RS09880	COG2814	Major facilitator Superfamily
H5A30_RS09885	COG1522	sequence-specific DNA binding
H5A30_RS09980	COG0582	viral genome integration into host DNA
H5A30_RS09990	COG2116	formate transmembrane transporter activity
H5A30_RS10000	COG0579	oxidoreductase
H5A30_RS10005	COG0583	DNA-binding transcription factor activity
H5A30_RS10010	COG1028	Short-chain dehydrogenase reductase Sdr
H5A30_RS10015	COG2067	long-chain fatty acid transport protein
H5A30_RS10020	COG3691	Protein conserved in bacteria
H5A30_RS10025	COG4106	trans-aconitate 2-methyltransferase activity
H5A30_RS10035	COG0183	Belongs to the thiolase family
H5A30_RS10040	COG1250	3-hydroxyacyl-CoA dehydrogenase
H5A30_RS10040	COG1024	Enoyl-CoA hydratase
H5A30_RS10050	COG3188	usher protein
H5A30_RS10070	COG2062	phosphohistidine phosphatase, SixA
H5A30_RS10075	COG2840	Smr protein MutS2
H5A30_RS10080	COG2890	protein-(glutamine-N5) methyltransferase activity
H5A30_RS10085	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H5A30_RS10090	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
H5A30_RS10095	COG0730	response to heat
H5A30_RS10100	COG3101	peptidyl-lysine hydroxylation
H5A30_RS10110	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
H5A30_RS10110	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H5A30_RS10115	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H5A30_RS10125	COG0697	spore germination
H5A30_RS10130	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H5A30_RS10135	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H5A30_RS10140	COG0101	tRNA pseudouridine synthase activity
H5A30_RS10145	COG0586	Pfam SNARE associated Golgi protein
H5A30_RS10150	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H5A30_RS10155	COG0285	dihydrofolate synthase activity
H5A30_RS10160	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
H5A30_RS10165	COG1286	toxin biosynthetic process
H5A30_RS10170	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
H5A30_RS10175	COG0163	prenyltransferase activity
H5A30_RS10190	COG4160	amino acid transport
H5A30_RS10195	COG4598	ABC transporter
H5A30_RS10200	COG1090	epimerase
H5A30_RS10205	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
H5A30_RS10210	COG0625	glutathione transferase activity
H5A30_RS10215	COG0622	Phosphoesterase
H5A30_RS10220	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
H5A30_RS10225	COG3739	integral membrane protein
H5A30_RS10230	COG0857	belongs to the CobB CobQ family
H5A30_RS10230	COG0280	phosphate acetyltransferase
H5A30_RS10235	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H5A30_RS10240	COG3092	negative regulation of chromosome organization
H5A30_RS10245	COG3013	Belongs to the UPF0304 family
H5A30_RS10250	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H5A30_RS10255	COG0490	domain, Protein
H5A30_RS10255	COG0471	metal ion transport
H5A30_RS10260	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
H5A30_RS10265	COG0436	Aminotransferase
H5A30_RS10270	COG0583	DNA-binding transcription factor activity
H5A30_RS10280	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H5A30_RS10285	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H5A30_RS10285	COG0649	NAD binding
H5A30_RS10290	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
H5A30_RS10305	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
H5A30_RS10310	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H5A30_RS10315	COG0839	Belongs to the complex I subunit 6 family
H5A30_RS10320	COG0713	ATP synthesis coupled electron transport
H5A30_RS10325	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H5A30_RS10330	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H5A30_RS10335	COG1007	ATP synthesis coupled electron transport
H5A30_RS10340	COG4575	ribosome binding
H5A30_RS10345	COG0366	Alpha amylase catalytic
H5A30_RS10350	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H5A30_RS10350	COG1263	PTS System
H5A30_RS10355	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H5A30_RS10365	COG0488	(ABC) transporter
H5A30_RS10375	COG4771	TonB-dependent receptor
H5A30_RS10400	COG4993	Dehydrogenase
H5A30_RS10410	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H5A30_RS10415	COG3058	Necessary for formate dehydrogenase activity
H5A30_RS10425	COG2149	membrane
H5A30_RS10430	COG4890	Cyd operon protein YbgT
H5A30_RS10435	COG1294	oxidase, subunit
H5A30_RS10440	COG1271	oxidase subunit
H5A30_RS10455	COG3707	response regulator
H5A30_RS10460	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H5A30_RS10470	COG1116	anion transmembrane transporter activity
H5A30_RS10475	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H5A30_RS10475	COG2146	nitrite reductase [NAD(P)H] activity
H5A30_RS10480	COG0243	molybdopterin cofactor binding
H5A30_RS10485	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H5A30_RS10485	COG1648	precorrin-2 dehydrogenase activity
H5A30_RS10490	COG5464	transposase or invertase
H5A30_RS10495	COG4807	Protein conserved in bacteria
H5A30_RS10500	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
H5A30_RS10510	COG1129	ABC transporter
H5A30_RS10515	COG1172	Belongs to the binding-protein-dependent transport system permease family
H5A30_RS10520	COG1172	Belongs to the binding-protein-dependent transport system permease family
H5A30_RS10530	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H5A30_RS10535	COG1070	Carbohydrate kinase
H5A30_RS10540	COG0640	Transcriptional regulator
H5A30_RS10545	COG1902	pentaerythritol trinitrate reductase activity
H5A30_RS10555	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H5A30_RS10560	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H5A30_RS10565	COG0745	RESPONSE REGULATOR receiver
H5A30_RS10570	COG2205	protein histidine kinase activity
H5A30_RS10605	COG2826	transposase and inactivated derivatives, IS30 family
H5A30_RS10615	COG0745	RESPONSE REGULATOR receiver
H5A30_RS10655	COG2826	transposase and inactivated derivatives, IS30 family
H5A30_RS10675	COG0765	amino acid transport
H5A30_RS10680	COG0765	amino acid transport
H5A30_RS10695	COG5002	protein histidine kinase activity
H5A30_RS10695	COG5000	phosphorelay sensor kinase activity
H5A30_RS10700	COG0745	RESPONSE REGULATOR receiver
H5A30_RS10720	COG4948	Mandelate Racemase Muconate Lactonizing
H5A30_RS10730	COG0659	secondary active sulfate transmembrane transporter activity
H5A30_RS10735	COG0481	GTPase activity
H5A30_RS10740	COG2951	lytic endotransglycosylase activity
H5A30_RS10760	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H5A30_RS10765	COG2814	Major facilitator Superfamily
H5A30_RS10790	COG1113	amino acid transport
H5A30_RS10810	COG2197	response regulator
H5A30_RS10815	COG0322	excinuclease ABC activity
H5A30_RS10820	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H5A30_RS10875	COG3706	GGDEF domain
H5A30_RS10885	COG0840	transmembrane signaling receptor activity
H5A30_RS10890	COG0697	spore germination
H5A30_RS10915	COG2198	Histidine kinase
H5A30_RS10915	COG0643	Histidine kinase
H5A30_RS10920	COG0835	chemotaxis
H5A30_RS10925	COG0840	transmembrane signaling receptor activity
H5A30_RS10930	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H5A30_RS10935	COG2201	protein-glutamate methylesterase activity
H5A30_RS10940	COG0745	RESPONSE REGULATOR receiver
H5A30_RS10950	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H5A30_RS10955	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H5A30_RS10970	COG2747	anti-sigma28 factor FlgM
H5A30_RS10980	COG1815	bacterial-type flagellum-dependent cell motility
H5A30_RS10985	COG1558	bacterial-type flagellum-dependent cell motility
H5A30_RS10990	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
H5A30_RS10995	COG1749	Flagellar hook protein flgE
H5A30_RS11000	COG4787	bacterial-type flagellum-dependent cell motility
H5A30_RS11010	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
H5A30_RS11015	COG1706	bacterial-type flagellum-dependent cell motility
H5A30_RS11065	COG1580	Controls the rotational direction of flagella during chemotaxis
H5A30_RS11085	COG1317	bacterial-type flagellum organization
H5A30_RS11100	COG1677	Flagellar hook-basal body complex protein FliE
H5A30_RS11125	COG0500	methyltransferase
H5A30_RS11165	COG1191	sigma factor activity
H5A30_RS11175	COG1702	phosphate starvation-inducible protein PhoH
H5A30_RS11190	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H5A30_RS11195	COG1309	transcriptional regulator
H5A30_RS11200	COG1012	belongs to the aldehyde dehydrogenase family
H5A30_RS11205	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
H5A30_RS11210	COG2979	Protein of unknown function (DUF533)
H5A30_RS11215	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H5A30_RS11220	COG1067	ATP-dependent peptidase activity
H5A30_RS11235	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
H5A30_RS11240	COG3070	regulator of competence-specific genes
H5A30_RS11245	COG1289	transmembrane transporter activity
H5A30_RS11250	COG3304	Inner membrane component domain
H5A30_RS11255	COG0210	DNA helicase
H5A30_RS11260	COG1803	Methylglyoxal synthase
H5A30_RS11270	COG1832	CoA-binding protein
H5A30_RS11275	COG3785	DNA binding
H5A30_RS11280	COG1254	Belongs to the acylphosphatase family
H5A30_RS11285	COG2920	part of a sulfur-relay system
H5A30_RS11290	COG0670	Belongs to the BI1 family
H5A30_RS11320	COG0589	response to stress
H5A30_RS11340	COG0840	transmembrane signaling receptor activity
H5A30_RS11355	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
H5A30_RS11360	COG2943	transferase activity, transferring hexosyl groups
H5A30_RS11365	COG1560	Kdo2-lipid A biosynthetic process
H5A30_RS11370	COG1902	pentaerythritol trinitrate reductase activity
H5A30_RS11375	COG1054	Belongs to the UPF0176 family
H5A30_RS11380	COG2353	YceI-like domain
H5A30_RS11385	COG3038	cytochrome b561
H5A30_RS11405	COG0418	dihydroorotase activity
H5A30_RS11415	COG1530	ribonuclease E activity
H5A30_RS11415	COG1530	ribonuclease E activity
H5A30_RS11420	COG0564	pseudouridine synthase activity
H5A30_RS11425	COG0424	maF-like protein
H5A30_RS11430	COG1399	metal-binding, possibly nucleic acid-binding protein
H5A30_RS11435	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H5A30_RS11440	COG0416	fatty acid biosynthetic process
H5A30_RS11445	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H5A30_RS11450	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H5A30_RS11460	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H5A30_RS11465	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H5A30_RS11470	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H5A30_RS11475	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H5A30_RS11480	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H5A30_RS11485	COG0470	DNA polymerase III
H5A30_RS11490	COG0084	hydrolase, TatD family'
H5A30_RS11495	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H5A30_RS11495	COG1263	PTS System
H5A30_RS11505	COG0477	Major facilitator Superfamily
H5A30_RS11510	COG0537	adenosine 5'-monophosphoramidase activity
H5A30_RS11520	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
H5A30_RS11530	COG1472	Belongs to the glycosyl hydrolase 3 family
H5A30_RS11535	COG3150	esterase
H5A30_RS11540	COG1252	NADH dehydrogenase
H5A30_RS11545	COG3134	Outer membrane lipoprotein
H5A30_RS11550	COG2814	Major facilitator Superfamily
H5A30_RS11560	COG1309	transcriptional regulator
H5A30_RS11565	COG0443	Heat shock 70 kDa protein
H5A30_RS11570	COG3547	Transposase (IS116 IS110 IS902 family)
H5A30_RS11575	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H5A30_RS11580	COG4591	ABC-type transport system involved in lipoprotein release permease component
H5A30_RS11585	COG1136	(ABC) transporter
H5A30_RS11590	COG4591	ABC-type transport system involved in lipoprotein release permease component
H5A30_RS11595	COG1940	carbohydrate kinase activity
H5A30_RS11605	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H5A30_RS11615	COG2226	methyltransferase
H5A30_RS11620	COG4139	cobalamin transport
H5A30_RS11625	COG0386	Belongs to the glutathione peroxidase family
H5A30_RS11630	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
H5A30_RS11635	COG0791	NLP P60 protein
H5A30_RS11640	COG0095	Lipoate-protein ligase
H5A30_RS11645	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
H5A30_RS11650	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
H5A30_RS11655	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H5A30_RS11660	COG4558	Periplasmic binding protein
H5A30_RS11665	COG3720	iron ion transport
H5A30_RS11670	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H5A30_RS11675	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
H5A30_RS11680	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H5A30_RS11680	COG0574	Belongs to the PEP-utilizing enzyme family
H5A30_RS11695	COG1477	protein flavinylation
H5A30_RS11705	COG0628	permease
H5A30_RS11710	COG0247	lactate metabolic process
H5A30_RS11710	COG0277	FAD linked oxidase domain protein
H5A30_RS11715	COG2050	protein possibly involved in aromatic compounds catabolism
H5A30_RS11725	COG0316	Belongs to the HesB IscA family
H5A30_RS11730	COG0719	Fe-S assembly protein
H5A30_RS11735	COG0396	ATPase activity
H5A30_RS11740	COG0719	Fe-S assembly protein
H5A30_RS11745	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H5A30_RS11750	COG2166	iron-sulfur cluster assembly
H5A30_RS11755	COG1376	ErfK ybiS ycfS ynhG family protein
H5A30_RS11755	COG1388	LysM domain
H5A30_RS11760	COG4238	major outer membrane lipoprotein
H5A30_RS11790	COG2382	esterase
H5A30_RS11800	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
H5A30_RS11805	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
H5A30_RS11810	COG0437	4 iron, 4 sulfur cluster binding
H5A30_RS11815	COG3301	Polysulphide reductase, NrfD
H5A30_RS11820	COG1138	Cytochrome C-type biogenesis protein
H5A30_RS11825	COG3088	subunit of a heme lyase
H5A30_RS11830	COG4235	cytochrome complex assembly
H5A30_RS11835	COG4133	protoheme IX ABC transporter activity
H5A30_RS11840	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H5A30_RS11845	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H5A30_RS11850	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H5A30_RS11855	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
H5A30_RS11860	COG1138	Cytochrome C-type biogenesis protein
H5A30_RS11865	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H5A30_RS11870	COG4235	cytochrome complex assembly
H5A30_RS11870	COG3088	subunit of a heme lyase
H5A30_RS11875	COG4235	cytochrome complex assembly
H5A30_RS11875	COG3088	subunit of a heme lyase
H5A30_RS11880	COG3547	Transposase (IS116 IS110 IS902 family)
H5A30_RS11885	COG3005	denitrification pathway
H5A30_RS11890	COG3043	anaerobic respiration
H5A30_RS11895	COG0348	domain, Protein
H5A30_RS11900	COG0437	4 iron, 4 sulfur cluster binding
H5A30_RS11905	COG0243	molybdopterin cofactor binding
H5A30_RS11910	COG3062	negative regulation of establishment of protein localization
H5A30_RS11915	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
H5A30_RS11915	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H5A30_RS11920	COG3850	Histidine kinase
H5A30_RS11925	COG2197	response regulator
H5A30_RS11960	COG2076	Multidrug Resistance protein
H5A30_RS11965	COG0561	phosphatase activity
H5A30_RS11975	COG1408	metallophosphoesterase
H5A30_RS11980	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
H5A30_RS12000	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H5A30_RS12005	COG1116	anion transmembrane transporter activity
H5A30_RS12010	COG3665	Urea carboxylase-associated protein
H5A30_RS12025	COG4770	biotin carboxylase activity
H5A30_RS12035	COG0534	Mate efflux family protein
H5A30_RS12040	COG0307	riboflavin synthase, alpha
H5A30_RS12045	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H5A30_RS12050	COG1609	Transcriptional regulator
H5A30_RS12060	COG0791	NLP P60 protein
H5A30_RS12065	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H5A30_RS12070	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H5A30_RS12075	COG0346	lactoylglutathione lyase activity
H5A30_RS12080	COG3313	Fe-S protein
H5A30_RS12095	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H5A30_RS12100	COG3895	Periplasmic Protein
H5A30_RS12105	COG0259	pyridoxamine-phosphate oxidase activity
H5A30_RS12110	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H5A30_RS12115	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
H5A30_RS12120	COG0625	glutathione transferase activity
H5A30_RS12125	COG1301	dicarboxylic acid transport
H5A30_RS12130	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
H5A30_RS12150	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H5A30_RS12155	COG0671	phosphoesterase, PA-phosphatase related
H5A30_RS12160	COG1879	ABC-type sugar transport system periplasmic component
H5A30_RS12170	COG1129	ABC transporter
H5A30_RS12175	COG1172	Belongs to the binding-protein-dependent transport system permease family
H5A30_RS12180	COG3959	Transketolase, thiamine diphosphate binding domain
H5A30_RS12185	COG3958	Transketolase
H5A30_RS12190	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H5A30_RS12195	COG1082	Xylose isomerase domain protein TIM barrel
H5A30_RS12205	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
H5A30_RS12210	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
H5A30_RS12215	COG0284	orotidine-5'-phosphate decarboxylase activity
H5A30_RS12220	COG0023	Translation Initiation Factor
H5A30_RS12230	COG0235	Class ii aldolase
H5A30_RS12235	COG1966	Carbon starvation protein
H5A30_RS12240	COG4989	oxidoreductase activity
H5A30_RS12245	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
H5A30_RS12250	COG0243	molybdopterin cofactor binding
H5A30_RS12255	COG0583	DNA-binding transcription factor activity
H5A30_RS12265	COG2271	Major facilitator Superfamily
H5A30_RS12305	COG4171	peptide transport system, permease
H5A30_RS12315	COG4166	transmembrane transport
H5A30_RS12335	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
H5A30_RS12340	COG1842	Phage shock protein A
H5A30_RS12350	COG1983	PspC domain protein
H5A30_RS12365	COG3210	domain, Protein
H5A30_RS12375	COG2831	hemolysin activation secretion protein
H5A30_RS12380	COG3106	COG3106 Predicted ATPase
H5A30_RS12385	COG3768	UPF0283 membrane protein
H5A30_RS12400	COG0514	ATP-dependent DNA helicase (RecQ)
H5A30_RS12420	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
H5A30_RS12425	COG2866	Carboxypeptidase
H5A30_RS12430	COG4166	transmembrane transport
H5A30_RS12435	COG0598	Magnesium transport protein CorA
H5A30_RS12445	COG0037	tRNA processing
H5A30_RS12475	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H5A30_RS12480	COG0840	transmembrane signaling receptor activity
H5A30_RS12485	COG0840	transmembrane signaling receptor activity
H5A30_RS12490	COG2911	Protein conserved in bacteria
H5A30_RS12500	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H5A30_RS12505	COG1643	Atp-dependent helicase
H5A30_RS12515	COG3300	MHYT domain
H5A30_RS12515	COG5001	Diguanylate cyclase
H5A30_RS12520	COG3591	Belongs to the peptidase S1B family
H5A30_RS12535	COG2205	protein histidine kinase activity
H5A30_RS12540	COG0745	RESPONSE REGULATOR receiver
H5A30_RS12570	COG1028	Short-chain dehydrogenase reductase Sdr
H5A30_RS12580	COG0659	secondary active sulfate transmembrane transporter activity
H5A30_RS12585	COG0387	Pfam Sodium calcium exchanger
H5A30_RS12595	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
H5A30_RS12610	COG2197	response regulator
H5A30_RS12615	COG3850	Histidine kinase
H5A30_RS12620	COG2223	nitrite transmembrane transporter activity
H5A30_RS12625	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
H5A30_RS12630	COG1140	nitrate reductase beta subunit
H5A30_RS12635	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
H5A30_RS12640	COG2181	nitrate reductase activity
H5A30_RS12645	COG0697	spore germination
H5A30_RS12650	COG1846	Transcriptional regulator
H5A30_RS12665	COG2423	ornithine cyclodeaminase activity
H5A30_RS12680	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H5A30_RS12685	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H5A30_RS12690	COG0322	excinuclease ABC activity
H5A30_RS12695	COG2261	transglycosylase associated protein
H5A30_RS12730	COG3842	ATPase activity
H5A30_RS12740	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H5A30_RS12745	COG1012	belongs to the aldehyde dehydrogenase family
H5A30_RS12755	COG1176	ABC-type spermidine putrescine transport system, permease component I
H5A30_RS12765	COG1028	Short-chain dehydrogenase reductase Sdr
H5A30_RS12775	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H5A30_RS12785	COG0671	phosphoesterase, PA-phosphatase related
H5A30_RS12790	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H5A30_RS12795	COG2011	ABC-type metal ion transport system permease component
H5A30_RS12800	COG4948	Mandelate Racemase Muconate Lactonizing
H5A30_RS12805	COG1464	Belongs to the NlpA lipoprotein family
H5A30_RS12825	COG0583	DNA-binding transcription factor activity
H5A30_RS12830	COG4792	protein secretion
H5A30_RS12840	COG4794	Type iii secretion
H5A30_RS12865	COG1157	protein secretion by the type III secretion system
H5A30_RS12890	COG3850	Histidine kinase
H5A30_RS12895	COG2197	response regulator
H5A30_RS12905	COG2200	EAL domain
H5A30_RS12920	COG4669	(LipO)protein
H5A30_RS12965	COG3501	Rhs element vgr protein
H5A30_RS13015	COG1802	Transcriptional regulator
H5A30_RS13020	COG2831	hemolysin activation secretion protein
H5A30_RS13025	COG3210	domain, Protein
H5A30_RS13085	COG2211	Major facilitator Superfamily
H5A30_RS13090	COG3507	Belongs to the glycosyl hydrolase 43 family
H5A30_RS13105	COG1802	Transcriptional regulator
H5A30_RS13125	COG1129	ABC transporter
H5A30_RS13145	COG2314	TM2 domain
H5A30_RS13155	COG1126	abc transporter atp-binding protein
H5A30_RS13160	COG0765	amino acid transport
H5A30_RS13170	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
H5A30_RS13180	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H5A30_RS13190	COG1473	amidohydrolase
H5A30_RS13195	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H5A30_RS13210	COG2234	aminopeptidase activity
H5A30_RS13215	COG2826	transposase and inactivated derivatives, IS30 family
H5A30_RS13220	COG1609	Transcriptional regulator
H5A30_RS13225	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H5A30_RS13225	COG1263	PTS System
H5A30_RS13230	COG2723	6-phospho-beta-galactosidase activity
H5A30_RS13235	COG0483	inositol monophosphate 1-phosphatase activity
H5A30_RS13240	COG0346	lactoylglutathione lyase activity
H5A30_RS13245	COG3443	Belongs to the bacterial solute-binding protein 9 family
H5A30_RS13250	COG0523	cobalamin synthesis protein
H5A30_RS13255	COG2755	lipolytic protein G-D-S-L family
H5A30_RS13270	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H5A30_RS13305	COG3958	Transketolase
H5A30_RS13310	COG3959	Transketolase, thiamine diphosphate binding domain
H5A30_RS13315	COG1028	Short-chain dehydrogenase reductase Sdr
H5A30_RS13320	COG2271	Major facilitator Superfamily
H5A30_RS13325	COG0583	DNA-binding transcription factor activity
H5A30_RS13330	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
H5A30_RS13340	COG0012	GTP binding
H5A30_RS13345	COG0193	aminoacyl-tRNA hydrolase activity
H5A30_RS13355	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H5A30_RS13360	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
H5A30_RS13365	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
H5A30_RS13370	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
H5A30_RS13375	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H5A30_RS13380	COG2890	protein-(glutamine-N5) methyltransferase activity
H5A30_RS13390	COG2912	Transglutaminase-like superfamily
H5A30_RS13395	COG2877	3-deoxy-8-phosphooctulonate synthase activity
H5A30_RS13405	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
H5A30_RS13410	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
H5A30_RS13420	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H5A30_RS13425	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H5A30_RS13430	COG0673	inositol 2-dehydrogenase activity
H5A30_RS13445	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H5A30_RS13475	COG4305	rare lipoprotein A
H5A30_RS13480	COG1764	response to oxidative stress
H5A30_RS13485	COG3783	Cytochrome b(562)
H5A30_RS13495	COG0738	Major facilitator superfamily
H5A30_RS13500	COG0456	acetyltransferase
H5A30_RS13575	COG5290	Psort location Cytoplasmic, score
H5A30_RS13660	COG4628	conserved protein (DUF2132)
H5A30_RS13665	COG1649	PFAM Uncharacterised BCR, COG1649
H5A30_RS13675	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H5A30_RS13680	COG0076	glutamate decarboxylase activity
H5A30_RS13685	COG0697	spore germination
H5A30_RS13690	COG1942	4-Oxalocrotonate Tautomerase
H5A30_RS13705	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
H5A30_RS13720	COG1215	transferase activity, transferring glycosyl groups
H5A30_RS13725	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H5A30_RS13730	COG4221	oxidoreductase activity
H5A30_RS13750	COG0477	Major facilitator Superfamily
H5A30_RS13755	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
H5A30_RS13760	COG1940	carbohydrate kinase activity
H5A30_RS13765	COG0583	DNA-binding transcription factor activity
H5A30_RS13770	COG2814	Major facilitator Superfamily
H5A30_RS13780	COG0114	fumarate hydratase activity
H5A30_RS13785	COG1482	cell wall glycoprotein biosynthetic process
H5A30_RS13790	COG5339	Protein conserved in bacteria
H5A30_RS13800	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H5A30_RS13810	COG0385	Bile acid
H5A30_RS13815	COG0673	inositol 2-dehydrogenase activity
H5A30_RS13825	COG1172	Belongs to the binding-protein-dependent transport system permease family
H5A30_RS13830	COG1129	ABC transporter
H5A30_RS13835	COG1879	ABC-type sugar transport system periplasmic component
H5A30_RS13840	COG1069	ribulokinase activity
H5A30_RS13845	COG2160	L-arabinose isomerase activity
H5A30_RS13855	COG4657	Part of a membrane complex involved in electron transport
H5A30_RS13860	COG2878	Part of a membrane complex involved in electron transport
H5A30_RS13865	COG4656	Part of a membrane complex involved in electron transport
H5A30_RS13870	COG4658	electron transport chain
H5A30_RS13875	COG4659	FMN binding
H5A30_RS13885	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H5A30_RS13890	COG3104	oligopeptide transport
H5A30_RS13910	COG0616	signal peptide processing
H5A30_RS13915	COG1028	Short-chain dehydrogenase reductase Sdr
H5A30_RS13920	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
H5A30_RS13925	COG1187	pseudouridine synthase activity
H5A30_RS13930	COG0009	L-threonylcarbamoyladenylate synthase
H5A30_RS13935	COG0613	PHP domain protein
H5A30_RS13955	COG0512	Glutamine amidotransferase of anthranilate synthase
H5A30_RS13960	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H5A30_RS13965	COG0134	indole-3-glycerol-phosphate synthase activity
H5A30_RS13965	COG0135	phosphoribosylanthranilate isomerase activity
H5A30_RS13970	COG0133	tryptophan synthase activity
H5A30_RS13975	COG0159	tryptophan synthase activity
H5A30_RS13980	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
H5A30_RS13985	COG3047	cAMP biosynthetic process
H5A30_RS13995	COG2917	probably involved in intracellular septation
H5A30_RS14000	COG1607	acyl-coa hydrolase
H5A30_RS14010	COG2350	Protein conserved in bacteria
H5A30_RS14025	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H5A30_RS14030	COG3099	Belongs to the UPF0263 family
H5A30_RS14040	COG0444	Belongs to the ABC transporter superfamily
H5A30_RS14045	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H5A30_RS14050	COG0601	transmembrane transport
H5A30_RS14065	COG1012	belongs to the aldehyde dehydrogenase family
H5A30_RS14065	COG1454	alcohol dehydrogenase
H5A30_RS14070	COG1435	thymidine kinase activity
H5A30_RS14080	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H5A30_RS14085	COG0745	RESPONSE REGULATOR receiver
H5A30_RS14090	COG1752	Esterase of the alpha-beta hydrolase superfamily
H5A30_RS14095	COG3012	SEC-C Motif Domain Protein
H5A30_RS14100	COG0788	formyltetrahydrofolate deformylase activity
H5A30_RS14110	COG2860	membrane
H5A30_RS14115	COG0708	Exodeoxyribonuclease III
H5A30_RS14125	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H5A30_RS14130	COG0778	Nitroreductase
H5A30_RS14135	COG0616	signal peptide processing
H5A30_RS14140	COG0252	asparaginase activity
H5A30_RS14145	COG1335	isochorismatase
H5A30_RS14150	COG3139	Protein of unknown function (DUF1315)
H5A30_RS14155	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H5A30_RS14170	COG0656	L-ascorbic acid biosynthetic process
H5A30_RS14175	COG3713	MltA-interacting MipA family protein
H5A30_RS14180	COG2766	serine protein kinase
H5A30_RS14185	COG2718	Belongs to the UPF0229 family
H5A30_RS14200	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H5A30_RS14205	COG0205	6-phosphofructokinase activity
H5A30_RS14225	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H5A30_RS14235	COG3684	Belongs to the aldolase LacD family
H5A30_RS14240	COG2719	SpoVR family
H5A30_RS14245	COG2186	Transcriptional regulator
H5A30_RS14250	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H5A30_RS14255	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
H5A30_RS14265	COG2983	Belongs to the UPF0260 family
H5A30_RS14270	COG0179	Fumarylacetoacetate (FAA) hydrolase
H5A30_RS14275	COG3100	YcgL domain-containing protein
H5A30_RS14280	COG0850	regulation of cytokinetic process
H5A30_RS14285	COG2894	cell division
H5A30_RS14290	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
H5A30_RS14295	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
H5A30_RS14300	COG0318	PFAM AMP-dependent synthetase and ligase
H5A30_RS14305	COG3065	identical protein binding
H5A30_RS14315	COG1199	ATP-dependent helicase activity
H5A30_RS14320	COG0251	oxidation-reduction process
H5A30_RS14325	COG3140	Belongs to the UPF0181 family
H5A30_RS14335	COG0494	nUDIX hydrolase
H5A30_RS14340	COG1760	l-serine dehydratase
H5A30_RS14360	COG1253	flavin adenine dinucleotide binding
H5A30_RS14365	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
H5A30_RS14365	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H5A30_RS14370	COG3715	PTS system
H5A30_RS14375	COG3716	PTS system mannose fructose sorbose family IID component
H5A30_RS14380	COG4811	Protein of unknown function (DUF986)
H5A30_RS14385	COG1971	Probably functions as a manganese efflux pump
H5A30_RS14390	COG2226	methyltransferase
H5A30_RS14405	COG0803	Belongs to the bacterial solute-binding protein 9 family
H5A30_RS14410	COG1121	(ABC) transporter
H5A30_RS14415	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H5A30_RS14420	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H5A30_RS14425	COG3001	Fructosamine kinase
H5A30_RS14435	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H5A30_RS14440	COG1917	Cupin 2, conserved barrel domain protein
H5A30_RS14445	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
H5A30_RS14450	COG1028	Short-chain dehydrogenase reductase Sdr
H5A30_RS14460	COG1175	transmembrane transport
H5A30_RS14465	COG0395	ABC-type sugar transport system, permease component
H5A30_RS14470	COG3842	ATPase activity
H5A30_RS14480	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
H5A30_RS14485	COG2755	lipolytic protein G-D-S-L family
H5A30_RS14485	COG0657	acetylesterase activity
H5A30_RS14490	COG1988	membrane-bound metal-dependent
H5A30_RS14495	COG1823	symporter activity
H5A30_RS14500	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H5A30_RS14505	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H5A30_RS14515	COG1132	(ABC) transporter
H5A30_RS14525	COG0776	regulation of translation
H5A30_RS14530	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H5A30_RS14530	COG0072	phenylalanine-tRNA ligase activity
H5A30_RS14535	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H5A30_RS14545	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
H5A30_RS14550	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H5A30_RS14555	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H5A30_RS14560	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H5A30_RS14565	COG1113	amino acid transport
H5A30_RS14580	COG0823	Involved in the tonB-independent uptake of proteins
H5A30_RS14585	COG0501	Belongs to the peptidase M48B family
H5A30_RS14595	COG1653	transport
H5A30_RS14600	COG2223	nitrite transmembrane transporter activity
H5A30_RS14605	COG3279	Response regulator of the LytR AlgR family
H5A30_RS14610	COG3275	phosphorelay sensor kinase activity
H5A30_RS14635	COG0348	domain, Protein
H5A30_RS14640	COG0538	isocitrate dehydrogenase activity
H5A30_RS14645	COG1187	pseudouridine synthase activity
H5A30_RS14655	COG0482	sulfurtransferase activity
H5A30_RS14660	COG2915	High frequency lysogenization protein hflD homolog
H5A30_RS14665	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H5A30_RS14680	COG2850	peptidyl-arginine hydroxylation
H5A30_RS14685	COG2195	Cleaves the N-terminal amino acid of tripeptides
H5A30_RS14690	COG3842	ATPase activity
H5A30_RS14700	COG1177	transmembrane transport
H5A30_RS14715	COG2223	nitrite transmembrane transporter activity
H5A30_RS14730	COG2207	Transcriptional regulator
H5A30_RS14740	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
H5A30_RS14745	COG1956	GAF domain-containing protein
H5A30_RS14750	COG2995	paraquat-inducible protein a
H5A30_RS14755	COG3008	intermembrane lipid transfer
H5A30_RS14760	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H5A30_RS14760	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
H5A30_RS14775	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
H5A30_RS14795	COG1278	Cold shock
H5A30_RS14805	COG1528	Iron-storage protein
H5A30_RS14815	COG1770	oligopeptidase
H5A30_RS14820	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
H5A30_RS14825	COG0800	Aldolase
H5A30_RS14830	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H5A30_RS14835	COG1737	Transcriptional regulator
H5A30_RS14840	COG0469	pyruvate kinase activity
H5A30_RS14845	COG1560	Kdo2-lipid A biosynthetic process
H5A30_RS14850	COG0739	heme binding
H5A30_RS14855	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
H5A30_RS14860	COG1121	(ABC) transporter
H5A30_RS14865	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H5A30_RS14870	COG1609	Transcriptional regulator
H5A30_RS14875	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H5A30_RS14880	COG1447	Phosphotransferase system cellobiose-specific component IIA
H5A30_RS14885	COG4580	involved in the transport of maltose and maltodextrins
H5A30_RS14890	COG2255	four-way junction helicase activity
H5A30_RS14895	COG0632	four-way junction helicase activity
H5A30_RS14900	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
H5A30_RS14905	COG0217	transcriptional regulatory protein
H5A30_RS14910	COG0494	nUDIX hydrolase
H5A30_RS14915	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H5A30_RS14920	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
H5A30_RS14925	COG1801	Protein of unknown function DUF72
H5A30_RS14930	COG3788	relative of glutathione S-transferase, MAPEG superfamily
H5A30_RS14935	COG2226	methyltransferase
H5A30_RS14940	COG0500	methyltransferase
H5A30_RS14945	COG3142	Participates in the control of copper homeostasis
H5A30_RS14950	COG3102	Protein conserved in bacteria
H5A30_RS14955	COG0018	arginyl-trna synthetase
H5A30_RS14960	COG0728	peptidoglycan biosynthetic process
H5A30_RS14970	COG3132	Protein of unknown function, DUF480
H5A30_RS14975	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H5A30_RS14980	COG0477	Major facilitator Superfamily
H5A30_RS14985	COG2999	glutathione oxidoreductase activity
H5A30_RS14995	COG3381	protein complex oligomerization
H5A30_RS15000	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
H5A30_RS15015	COG0840	transmembrane signaling receptor activity
H5A30_RS15020	COG3130	regulation of translation
H5A30_RS15025	COG3009	Protein conserved in bacteria
H5A30_RS15030	COG3008	intermembrane lipid transfer
H5A30_RS15030	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H5A30_RS15035	COG2995	paraquat-inducible protein a
H5A30_RS15040	COG0488	(ABC) transporter
H5A30_RS15045	COG0116	Belongs to the methyltransferase superfamily
H5A30_RS15045	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H5A30_RS15050	COG0633	Ferredoxin
H5A30_RS15050	COG3217	Mosc domain protein beta barrel domain protein
H5A30_RS15060	COG0167	dihydroorotate dehydrogenase activity
H5A30_RS15065	COG0308	aminopeptidase N
H5A30_RS15070	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
H5A30_RS15075	COG0017	Asparaginyl-tRNA synthetase
H5A30_RS15085	COG1448	Aminotransferase
H5A30_RS15090	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H5A30_RS15095	COG3108	Peptidase M15
H5A30_RS15100	COG2989	Protein conserved in bacteria
H5A30_RS15105	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
H5A30_RS15110	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
H5A30_RS15115	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
H5A30_RS15120	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H5A30_RS15125	COG1434	Gram-negative-bacterium-type cell wall biogenesis
H5A30_RS15130	COG3173	Aminoglycoside phosphotransferase
H5A30_RS15140	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
H5A30_RS15145	COG2835	tetraacyldisaccharide 4'-kinase activity
H5A30_RS15150	COG1663	tetraacyldisaccharide 4'-kinase activity
H5A30_RS15155	COG1132	(ABC) transporter
H5A30_RS15160	COG2333	competence protein COMEC
H5A30_RS15160	COG0658	competence protein
H5A30_RS15165	COG2926	Belongs to the UPF0265 family
H5A30_RS15170	COG4604	ABC transporter, ATP-binding protein
H5A30_RS15175	COG4605	iron ion homeostasis
H5A30_RS15185	COG4607	ABC-type enterochelin transport system periplasmic component
H5A30_RS15190	COG2925	Exonuclease
H5A30_RS15195	COG0531	amino acid
H5A30_RS15200	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
H5A30_RS15205	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
H5A30_RS15225	COG3052	prosthetic group binding
H5A30_RS15230	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
H5A30_RS15235	COG0179	Fumarylacetoacetate (FAA) hydrolase
H5A30_RS15240	COG3493	citrate carrier protein
H5A30_RS15250	COG4565	transcriptional regulatory protein
H5A30_RS15255	COG0840	transmembrane signaling receptor activity
H5A30_RS15260	COG0840	transmembrane signaling receptor activity
H5A30_RS15265	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H5A30_RS15275	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H5A30_RS15280	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H5A30_RS15285	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H5A30_RS15290	COG0131	Imidazoleglycerol-phosphate dehydratase
H5A30_RS15290	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H5A30_RS15295	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H5A30_RS15300	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H5A30_RS15305	COG0107	imidazoleglycerol-phosphate synthase activity
H5A30_RS15310	COG0140	phosphoribosyl-ATP diphosphatase activity
H5A30_RS15310	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H5A30_RS15315	COG0776	regulation of translation
H5A30_RS15320	COG0539	negative regulation of cytoplasmic translation
H5A30_RS15325	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H5A30_RS15330	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H5A30_RS15335	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
H5A30_RS15340	COG1944	ATP diphosphatase activity
H5A30_RS15345	COG2116	formate transmembrane transporter activity
H5A30_RS15350	COG1882	Formate acetyltransferase
H5A30_RS15355	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H5A30_RS15380	COG2814	Major facilitator Superfamily
H5A30_RS15385	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H5A30_RS15390	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H5A30_RS15395	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
H5A30_RS15400	COG1674	ftsk spoiiie
H5A30_RS15400	COG3107	peptidoglycan biosynthetic process
H5A30_RS15410	COG0492	ferredoxin-NADP+ reductase activity
H5A30_RS15415	COG4988	ABC transporter
H5A30_RS15420	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
H5A30_RS15425	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H5A30_RS15430	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
H5A30_RS15440	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H5A30_RS15445	COG0542	response to heat
H5A30_RS15450	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H5A30_RS15455	COG1278	Cold shock
H5A30_RS15460	COG3593	DNA synthesis involved in DNA repair
H5A30_RS15465	COG2431	L-lysine efflux transmembrane transporter activity
H5A30_RS15470	COG1151	hydroxylamine reductase activity
H5A30_RS15475	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H5A30_RS15480	COG0702	epimerase
H5A30_RS15485	COG3023	N-Acetylmuramoyl-L-alanine amidase
H5A30_RS15490	COG0393	Putative heavy-metal-binding
H5A30_RS15495	COG1126	abc transporter atp-binding protein
H5A30_RS15500	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H5A30_RS15505	COG4215	(ABC) transporter
H5A30_RS15510	COG4160	amino acid transport
H5A30_RS15515	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H5A30_RS15520	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H5A30_RS15530	COG1177	transmembrane transport
H5A30_RS15535	COG1176	ABC-type spermidine putrescine transport system, permease component I
H5A30_RS15540	COG3842	ATPase activity
H5A30_RS15545	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
H5A30_RS15555	COG0189	ligase activity
H5A30_RS15560	COG0778	Nitroreductase
H5A30_RS15575	COG2985	domain, Protein
H5A30_RS15575	COG0569	domain protein
H5A30_RS15580	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
H5A30_RS15585	COG1349	DNA-binding transcription factor activity
H5A30_RS15590	COG1686	Belongs to the peptidase S11 family
H5A30_RS15595	COG2011	ABC-type metal ion transport system permease component
H5A30_RS15600	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H5A30_RS15610	COG0625	glutathione transferase activity
H5A30_RS15615	COG2133	pyrroloquinoline quinone binding
H5A30_RS15645	COG1537	nuclear-transcribed mRNA catabolic process, no-go decay
H5A30_RS15660	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H5A30_RS15665	COG2949	membrane
H5A30_RS15670	COG2311	Membrane
H5A30_RS15675	COG0302	gtp cyclohydrolase
H5A30_RS15680	COG0840	transmembrane signaling receptor activity
H5A30_RS15685	COG0583	DNA-binding transcription factor activity
H5A30_RS15710	COG0371	Dehydrogenase
H5A30_RS15715	COG1129	ABC transporter
H5A30_RS15720	COG1172	Belongs to the binding-protein-dependent transport system permease family
H5A30_RS15725	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H5A30_RS15730	COG4771	TonB-dependent receptor
H5A30_RS15735	COG0833	amino acid
H5A30_RS15740	COG0583	DNA-binding transcription factor activity
H5A30_RS15745	COG2855	membrane
H5A30_RS15750	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
H5A30_RS15755	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H5A30_RS15755	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
H5A30_RS15755	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H5A30_RS15760	COG1105	Belongs to the carbohydrate kinase PfkB family
H5A30_RS15765	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H5A30_RS15765	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H5A30_RS15780	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H5A30_RS15785	COG0523	cobalamin synthesis protein
H5A30_RS15790	COG0671	phosphoesterase, PA-phosphatase related
H5A30_RS15795	COG0791	NLP P60 protein
H5A30_RS15800	COG4166	transmembrane transport
H5A30_RS15805	COG4174	ABC transporter (Permease)
H5A30_RS15810	COG4239	(ABC) transporter, permease
H5A30_RS15815	COG4172	Belongs to the ABC transporter superfamily
H5A30_RS15825	COG2814	Major facilitator Superfamily
H5A30_RS15840	COG1061	Type III restriction enzyme res subunit
H5A30_RS15845	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H5A30_RS15855	COG3081	Nucleoid-associated protein
H5A30_RS15860	COG3082	Protein of unknown function (DUF1414)
H5A30_RS15865	COG3083	sulfuric ester hydrolase activity
H5A30_RS15885	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
H5A30_RS15895	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H5A30_RS15900	COG0534	Mate efflux family protein
H5A30_RS15905	COG2807	transmembrane transport
H5A30_RS15910	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
H5A30_RS15920	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H5A30_RS15920	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H5A30_RS15925	COG0783	Belongs to the Dps family
H5A30_RS15930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H5A30_RS15935	COG0765	amino acid transport
H5A30_RS15940	COG1126	abc transporter atp-binding protein
H5A30_RS15950	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H5A30_RS16015	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H5A30_RS16105	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
H5A30_RS16120	COG1686	Belongs to the peptidase S11 family
H5A30_RS16145	COG2040	homocysteine
H5A30_RS16150	COG0833	amino acid
H5A30_RS16155	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H5A30_RS16160	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H5A30_RS16165	COG0747	negative chemotaxis
H5A30_RS16170	COG2195	Cleaves the N-terminal amino acid of tripeptides
H5A30_RS16175	COG2207	Transcriptional regulator
H5A30_RS16175	COG3708	Transcriptional regulator
H5A30_RS16185	COG0513	Belongs to the DEAD box helicase family
H5A30_RS16195	COG1120	ATPase activity
H5A30_RS16200	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H5A30_RS16205	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H5A30_RS16210	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H5A30_RS16225	COG1131	(ABC) transporter
H5A30_RS16230	COG0842	Transport permease protein
H5A30_RS16235	COG0842	Transport permease protein
H5A30_RS16240	COG0670	Belongs to the BI1 family
H5A30_RS16245	COG0314	molybdopterin synthase activity
H5A30_RS16250	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
H5A30_RS16255	COG0315	cyclic pyranopterin monophosphate synthase activity
H5A30_RS16260	COG0521	Mo-molybdopterin cofactor biosynthetic process
H5A30_RS16265	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H5A30_RS16280	COG0556	nucleotide-excision repair
H5A30_RS16300	COG3157	Type VI secretion system effector, Hcp
H5A30_RS16305	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
H5A30_RS16310	COG2226	methyltransferase
H5A30_RS16315	COG0156	8-amino-7-oxononanoate synthase activity
H5A30_RS16320	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H5A30_RS16330	COG5297	Belongs to the glycosyl hydrolase family 6
H5A30_RS16335	COG1380	Effector of murein hydrolase LrgA
H5A30_RS16340	COG1346	cytolysis
H5A30_RS16345	COG0295	cytidine deaminase activity
H5A30_RS16350	COG0281	malic enzyme
H5A30_RS16355	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H5A30_RS16360	COG0601	transmembrane transport
H5A30_RS16365	COG0747	negative chemotaxis
H5A30_RS16370	COG4172	Belongs to the ABC transporter superfamily
H5A30_RS16375	COG0303	'Molybdopterin
H5A30_RS16380	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H5A30_RS16400	COG0401	homolog of Blt101
H5A30_RS16415	COG3228	Belongs to the MtfA family
H5A30_RS16425	COG0582	viral genome integration into host DNA
H5A30_RS16440	COG3423	Transcriptional regulator
H5A30_RS16460	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H5A30_RS16515	COG3736	Type IV secretory pathway, component VirB8
H5A30_RS16520	COG3504	Conjugal transfer protein
H5A30_RS16530	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
H5A30_RS16570	COG4227	nucleotidyltransferase activity
H5A30_RS16585	COG1201	RNA secondary structure unwinding
H5A30_RS16635	COG3272	Protein of unknown function (DUF1722)
H5A30_RS16655	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H5A30_RS16670	COG0300	oxidoreductase activity
H5A30_RS16680	COG0789	Transcriptional regulator
H5A30_RS16710	COG3122	Protein conserved in bacteria
H5A30_RS16720	COG2723	6-phospho-beta-galactosidase activity
H5A30_RS16725	COG4978	Transcriptional regulator
H5A30_RS16725	COG0789	Transcriptional regulator
H5A30_RS16730	COG2814	Major facilitator Superfamily
H5A30_RS16735	COG0640	Transcriptional regulator
H5A30_RS16740	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H5A30_RS16750	COG1733	regulation of RNA biosynthetic process
H5A30_RS16755	COG2910	NAD(P)H-binding
H5A30_RS16760	COG0625	glutathione transferase activity
H5A30_RS16765	COG2814	Major facilitator Superfamily
H5A30_RS16770	COG3226	Transcriptional regulator
H5A30_RS16780	COG0784	Response regulator, receiver
H5A30_RS16780	COG0835	chemotaxis
H5A30_RS16795	COG2995	paraquat-inducible protein a
H5A30_RS16800	COG3008	intermembrane lipid transfer
H5A30_RS16800	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H5A30_RS16820	COG1132	(ABC) transporter
H5A30_RS16825	COG2375	cellular response to nickel ion
H5A30_RS16825	COG1132	(ABC) transporter
H5A30_RS16845	COG4771	TonB-dependent receptor
H5A30_RS16865	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H5A30_RS16880	COG5464	transposase or invertase
H5A30_RS16885	COG4172	Belongs to the ABC transporter superfamily
H5A30_RS16900	COG0747	negative chemotaxis
H5A30_RS16905	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H5A30_RS16910	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H5A30_RS16920	COG0477	Major facilitator Superfamily
H5A30_RS16940	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H5A30_RS16945	COG1012	belongs to the aldehyde dehydrogenase family
H5A30_RS16990	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
H5A30_RS16995	COG0371	Dehydrogenase
H5A30_RS17000	COG1301	dicarboxylic acid transport
H5A30_RS17015	COG0697	spore germination
H5A30_RS17020	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H5A30_RS17025	COG0577	efflux transmembrane transporter activity
H5A30_RS17025	COG1136	(ABC) transporter
H5A30_RS17035	COG0577	efflux transmembrane transporter activity
H5A30_RS17035	COG1136	(ABC) transporter
H5A30_RS17050	COG0672	)-iron permease
H5A30_RS17060	COG3383	formate dehydrogenase (NAD+) activity
H5A30_RS17065	COG2851	Citrate transporter
H5A30_RS17075	COG1301	dicarboxylic acid transport
H5A30_RS17080	COG0583	DNA-binding transcription factor activity
H5A30_RS17095	COG1464	Belongs to the NlpA lipoprotein family
H5A30_RS17110	COG2271	Major facilitator Superfamily
H5A30_RS17115	COG1840	ABC-type Fe3 transport system, periplasmic component
H5A30_RS17125	COG3842	ATPase activity
H5A30_RS17130	COG3547	Transposase (IS116 IS110 IS902 family)
H5A30_RS17135	COG1609	Transcriptional regulator
H5A30_RS17140	COG3250	beta-galactosidase activity
H5A30_RS17145	COG2223	nitrite transmembrane transporter activity
H5A30_RS17180	COG2910	NAD(P)H-binding
H5A30_RS17185	COG0583	DNA-binding transcription factor activity
H5A30_RS17195	COG0583	DNA-binding transcription factor activity
H5A30_RS17205	COG3615	Tellurite resistance protein tehB
H5A30_RS17215	COG2199	diguanylate cyclase activity
H5A30_RS17215	COG2203	Gaf domain
H5A30_RS17220	COG1263	PTS System
H5A30_RS17220	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H5A30_RS17220	COG2190	(PTS) system
H5A30_RS17225	COG2723	6-phospho-beta-galactosidase activity
H5A30_RS17235	COG1840	ABC-type Fe3 transport system, periplasmic component
H5A30_RS17240	COG4208	sulfate ABC transporter
H5A30_RS17245	COG3842	ATPase activity
H5A30_RS17260	COG3718	enzyme involved in inositol metabolism
H5A30_RS17270	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H5A30_RS17280	COG1172	Belongs to the binding-protein-dependent transport system permease family
H5A30_RS17295	COG0673	inositol 2-dehydrogenase activity
H5A30_RS17300	COG3962	Belongs to the TPP enzyme family
H5A30_RS17325	COG3706	GGDEF domain
H5A30_RS17330	COG3711	transcriptional antiterminator
H5A30_RS17335	COG2723	6-phospho-beta-galactosidase activity
H5A30_RS17345	COG1605	Chorismate mutase
H5A30_RS17350	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H5A30_RS17375	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H5A30_RS17385	COG1215	transferase activity, transferring glycosyl groups
H5A30_RS17395	COG1051	belongs to the nudix hydrolase family
H5A30_RS17400	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H5A30_RS17405	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
H5A30_RS17425	COG0110	maltose O-acetyltransferase activity
H5A30_RS17435	COG1216	Glycosyl transferase, family 2
H5A30_RS17435	COG0463	Glycosyl transferase, family 2
H5A30_RS17440	COG2244	polysaccharide biosynthetic process
H5A30_RS17450	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H5A30_RS17460	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
H5A30_RS17480	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H5A30_RS17485	COG1253	flavin adenine dinucleotide binding
H5A30_RS17490	COG3069	C4-dicarboxylate transmembrane transporter activity
H5A30_RS17495	COG2982	Protein involved in outer membrane biogenesis
H5A30_RS17500	COG0717	Belongs to the dCTP deaminase family
H5A30_RS17505	COG0572	uridine kinase
H5A30_RS17510	COG0489	protein tyrosine kinase activity
H5A30_RS17515	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H5A30_RS17515	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H5A30_RS17520	COG3383	formate dehydrogenase (NAD+) activity
H5A30_RS17520	COG0243	molybdopterin cofactor binding
H5A30_RS17525	COG0437	4 iron, 4 sulfur cluster binding
H5A30_RS17530	COG2864	formate dehydrogenase
H5A30_RS17535	COG3547	Transposase (IS116 IS110 IS902 family)
H5A30_RS17550	COG2706	6-phosphogluconolactonase activity
H5A30_RS17560	COG0561	phosphatase activity
H5A30_RS17565	COG0837	glucose binding
H5A30_RS17570	COG2211	Major facilitator Superfamily
H5A30_RS17580	COG0673	inositol 2-dehydrogenase activity
H5A30_RS17595	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
H5A30_RS17600	COG4149	molybdate abc transporter
H5A30_RS17605	COG0725	ABC transporter, periplasmic molybdate-binding protein
H5A30_RS17615	COG2005	Transcriptional regulator
H5A30_RS17615	COG3585	molybdate ion transport
H5A30_RS17620	COG1119	ATPase activity
H5A30_RS17625	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H5A30_RS17630	COG2017	converts alpha-aldose to the beta-anomer
H5A30_RS17650	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H5A30_RS17655	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H5A30_RS17660	COG0588	phosphoglycerate mutase activity
H5A30_RS17665	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H5A30_RS17670	COG1230	cation diffusion facilitator family transporter
H5A30_RS17680	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H5A30_RS17690	COG1811	Na channel or pump
H5A30_RS17705	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
H5A30_RS17710	COG2885	chlorophyll binding
H5A30_RS17715	COG0823	Involved in the tonB-independent uptake of proteins
H5A30_RS17720	COG3064	Membrane
H5A30_RS17725	COG0848	biopolymer transport protein
H5A30_RS17730	COG0811	peptide transport
H5A30_RS17735	COG0824	Thioesterase
H5A30_RS17740	COG3790	cyd operon protein YbgE
H5A30_RS17745	COG4890	Cyd operon protein YbgT
H5A30_RS17750	COG1294	oxidase, subunit
H5A30_RS17755	COG1271	oxidase subunit
H5A30_RS17765	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
H5A30_RS17770	COG0045	succinate-CoA ligase (ADP-forming) activity
H5A30_RS17775	COG0508	dehydrogenase complex catalyzes the overall conversion of
H5A30_RS17780	COG0567	Dehydrogenase, E1 component
H5A30_RS17785	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H5A30_RS17790	COG1053	succinate dehydrogenase
H5A30_RS17795	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
H5A30_RS17815	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H5A30_RS17820	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
H5A30_RS17825	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
H5A30_RS17830	COG1984	allophanate hydrolase subunit 2
H5A30_RS17835	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
H5A30_RS17840	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H5A30_RS17845	COG0415	Belongs to the DNA photolyase family
H5A30_RS17850	COG3272	Protein of unknown function (DUF1722)
H5A30_RS17855	COG3842	ATPase activity
H5A30_RS17860	COG1840	ABC-type Fe3 transport system, periplasmic component
H5A30_RS17880	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
H5A30_RS17885	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
H5A30_RS17890	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
H5A30_RS17895	COG3547	Transposase (IS116 IS110 IS902 family)
H5A30_RS17900	COG2205	protein histidine kinase activity
H5A30_RS17905	COG0745	RESPONSE REGULATOR receiver
H5A30_RS17915	COG0033	Phosphoglucomutase
H5A30_RS17920	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
H5A30_RS17925	COG0596	Alpha beta hydrolase
H5A30_RS17935	COG0840	transmembrane signaling receptor activity
H5A30_RS17940	COG0716	FMN binding
H5A30_RS17945	COG0735	belongs to the Fur family
H5A30_RS17950	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H5A30_RS17955	COG1263	PTS System
H5A30_RS17955	COG2190	(PTS) system
H5A30_RS17955	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H5A30_RS17960	COG0363	glucosamine-6-phosphate deaminase activity
H5A30_RS17965	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H5A30_RS17970	COG1846	Transcriptional regulator
H5A30_RS17970	COG1940	carbohydrate kinase activity
H5A30_RS17975	COG0367	asparagine synthase
H5A30_RS18020	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H5A30_RS18025	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H5A30_RS18030	COG1702	phosphate starvation-inducible protein PhoH
H5A30_RS18035	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H5A30_RS18045	COG0815	Transfers the fatty acyl group on membrane lipoproteins
H5A30_RS18055	COG0765	amino acid transport
H5A30_RS18060	COG0765	amino acid transport
H5A30_RS18065	COG1126	abc transporter atp-binding protein
H5A30_RS18070	COG3547	Transposase (IS116 IS110 IS902 family)
H5A30_RS18075	COG2888	peptidyl-tyrosine sulfation
H5A30_RS18080	COG0495	leucyl-tRNA aminoacylation
H5A30_RS18085	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
H5A30_RS18090	COG1466	dna polymerase III delta subunit
H5A30_RS18095	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H5A30_RS18100	COG0799	negative regulation of ribosome biogenesis
H5A30_RS18105	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
H5A30_RS18110	COG0768	penicillin binding
H5A30_RS18115	COG0772	Belongs to the SEDS family
H5A30_RS18120	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H5A30_RS18125	COG1686	Belongs to the peptidase S11 family
H5A30_RS18130	COG2921	Belongs to the UPF0250 family
H5A30_RS18135	COG0321	lipoyl(octanoyl) transferase activity
H5A30_RS18140	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H5A30_RS18145	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H5A30_RS18150	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H5A30_RS18160	COG1794	racemase activity, acting on amino acids and derivatives
H5A30_RS18170	COG1393	Belongs to the ArsC family
H5A30_RS18175	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H5A30_RS18180	COG1876	peptidase activity
H5A30_RS18195	COG0400	carboxylic ester hydrolase activity
H5A30_RS18200	COG3813	Protein conserved in bacteria
H5A30_RS18210	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H5A30_RS18220	COG4178	(ABC) transporter
H5A30_RS18225	COG4774	siderophore transport
H5A30_RS18230	COG1595	DNA-templated transcription, initiation
H5A30_RS18235	COG3712	iron ion homeostasis
H5A30_RS18240	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
H5A30_RS18255	COG0312	modulator of DNA gyrase
H5A30_RS18260	COG0312	modulator of DNA gyrase
H5A30_RS18265	COG3118	belongs to the thioredoxin family
H5A30_RS18270	COG1444	tRNA N-acetyltransferase activity
H5A30_RS18275	COG2707	UPF0756 membrane protein
H5A30_RS18280	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H5A30_RS18285	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
H5A30_RS18295	COG2716	regulation of RNA biosynthetic process
H5A30_RS18300	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H5A30_RS18305	COG4783	chaperone-mediated protein folding
H5A30_RS18310	COG1393	Belongs to the ArsC family
H5A30_RS18315	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H5A30_RS18320	COG2233	PERMEase
H5A30_RS18325	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H5A30_RS18330	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H5A30_RS18335	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H5A30_RS18340	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H5A30_RS18350	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H5A30_RS18355	COG3547	Transposase (IS116 IS110 IS902 family)
H5A30_RS18360	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
H5A30_RS18365	COG4181	ATPase activity
H5A30_RS18370	COG2755	lipolytic protein G-D-S-L family
H5A30_RS18375	COG0300	oxidoreductase activity
H5A30_RS18380	COG3118	belongs to the thioredoxin family
H5A30_RS18390	COG0814	amino acid
H5A30_RS18400	COG0753	catalase activity
H5A30_RS18410	COG1441	menaquinone biosynthetic process
H5A30_RS18415	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
H5A30_RS18420	COG0596	Alpha beta hydrolase
H5A30_RS18425	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
H5A30_RS18430	COG1169	isochorismate synthase
H5A30_RS18435	COG2223	nitrite transmembrane transporter activity
H5A30_RS18440	COG0642	Histidine kinase
H5A30_RS18440	COG2198	Histidine kinase
H5A30_RS18445	COG2197	response regulator
H5A30_RS18450	COG0784	Response regulator, receiver
H5A30_RS18450	COG2205	protein histidine kinase activity
H5A30_RS18460	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H5A30_RS18465	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H5A30_RS18470	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H5A30_RS18475	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H5A30_RS18480	COG0330	HflC and HflK could
H5A30_RS18485	COG1585	Membrane protein implicated in regulation of membrane protease activity
H5A30_RS18495	COG2217	Heavy metal translocating P-type atpase
H5A30_RS18510	COG3735	TraB family
H5A30_RS18520	COG5434	Belongs to the glycosyl hydrolase 28 family
H5A30_RS18525	COG0523	cobalamin synthesis protein
H5A30_RS18530	COG2879	small protein
H5A30_RS18535	COG1966	Carbon starvation protein
H5A30_RS18560	COG0737	Belongs to the 5'-nucleotidase family
H5A30_RS18565	COG4651	solute:proton antiporter activity
H5A30_RS18565	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H5A30_RS18570	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H5A30_RS18575	COG0563	adenylate kinase activity
H5A30_RS18580	COG0326	Molecular chaperone. Has ATPase activity
H5A30_RS18585	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H5A30_RS18590	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H5A30_RS18600	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H5A30_RS18605	COG2832	Protein of unknown function (DUF454)
H5A30_RS18620	COG1309	transcriptional regulator
H5A30_RS18625	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H5A30_RS18630	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H5A30_RS18635	COG0254	rRNA binding
H5A30_RS18640	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H5A30_RS18660	COG3695	enzyme binding
H5A30_RS18665	COG3126	Type III secretion system lipoprotein chaperone (YscW)
H5A30_RS18670	COG1946	Acyl-CoA thioesterase
H5A30_RS18675	COG0004	ammonium transporteR
H5A30_RS18680	COG0347	Belongs to the P(II) protein family
H5A30_RS18685	COG1132	(ABC) transporter
H5A30_RS18690	COG1132	(ABC) transporter
H5A30_RS18695	COG1522	sequence-specific DNA binding
H5A30_RS18705	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H5A30_RS18710	COG0824	Thioesterase
H5A30_RS18715	COG1555	photosystem II stabilization
H5A30_RS18720	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H5A30_RS18725	COG0776	regulation of translation
H5A30_RS18730	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H5A30_RS18735	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H5A30_RS18740	COG0740	serine-type endopeptidase activity
H5A30_RS18745	COG0544	peptidyl-prolyl cis-trans isomerase activity
H5A30_RS18750	COG0271	Belongs to the BolA IbaG family
H5A30_RS18755	COG3056	Lipoprotein
H5A30_RS18760	COG2223	nitrite transmembrane transporter activity
H5A30_RS18765	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H5A30_RS18770	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H5A30_RS18775	COG1845	cytochrome c oxidase, subunit III
H5A30_RS18780	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H5A30_RS18785	COG0109	protoheme IX farnesyltransferase activity
H5A30_RS18790	COG2814	Major facilitator Superfamily
H5A30_RS18795	COG1666	GTP binding
H5A30_RS18800	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H5A30_RS18810	COG0301	tRNA thio-modification
H5A30_RS18810	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H5A30_RS18815	COG1722	exodeoxyribonuclease VII activity
H5A30_RS18820	COG0142	geranyltranstransferase activity
H5A30_RS18825	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H5A30_RS18830	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H5A30_RS18835	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H5A30_RS18840	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H5A30_RS18845	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H5A30_RS18850	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H5A30_RS18850	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H5A30_RS18855	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H5A30_RS18860	COG4238	major outer membrane lipoprotein
H5A30_RS18865	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H5A30_RS18870	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H5A30_RS18875	COG1862	Preprotein translocase
H5A30_RS18880	COG0343	queuine tRNA-ribosyltransferase activity
H5A30_RS18885	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H5A30_RS18890	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
H5A30_RS18895	COG0450	alkyl hydroperoxide reductase
H5A30_RS18900	COG0668	transmembrane transport
H5A30_RS18905	COG3547	Transposase (IS116 IS110 IS902 family)
H5A30_RS18915	COG1114	Component of the transport system for branched-chain amino acids
H5A30_RS18920	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
H5A30_RS18940	COG0420	3'-5' exonuclease activity
H5A30_RS18945	COG0419	ATPase involved in DNA repair
H5A30_RS18950	COG1940	carbohydrate kinase activity
H5A30_RS18955	COG2974	May be involved in recombination
H5A30_RS18965	COG2188	Transcriptional regulator
H5A30_RS18970	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H5A30_RS18975	COG1397	ADP-ribosylglycohydrolase
H5A30_RS18985	COG3123	guanosine phosphorylase activity
H5A30_RS18990	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H5A30_RS19000	COG4615	Cyclic peptide transporter
H5A30_RS19030	COG5297	Belongs to the glycosyl hydrolase family 6
H5A30_RS19035	COG1312	Catalyzes the dehydration of D-mannonate
H5A30_RS19040	COG2186	Transcriptional regulator
H5A30_RS19070	COG0583	DNA-binding transcription factor activity
H5A30_RS19080	COG2951	lytic endotransglycosylase activity
H5A30_RS19085	COG2824	Alkylphosphonate utilization operon protein PhnA
H5A30_RS19090	COG4943	cyclic-guanylate-specific phosphodiesterase activity
H5A30_RS19095	COG1595	DNA-templated transcription, initiation
H5A30_RS19100	COG3712	iron ion homeostasis
H5A30_RS19105	COG4772	TonB-dependent receptor
H5A30_RS19110	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
H5A30_RS19115	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H5A30_RS19120	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H5A30_RS19125	COG1120	ATPase activity
H5A30_RS19150	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H5A30_RS19155	COG3015	lipoprotein NlpE involved in copper resistance
H5A30_RS19170	COG4568	rho-dependent transcription termination
H5A30_RS19175	COG0037	tRNA processing
H5A30_RS19180	COG0346	lactoylglutathione lyase activity
H5A30_RS19185	COG0825	malonyl-CoA metabolic process
H5A30_RS19190	COG0587	DNA-directed DNA polymerase activity
H5A30_RS19195	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H5A30_RS19200	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H5A30_RS19205	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H5A30_RS19210	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H5A30_RS19215	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H5A30_RS19220	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
H5A30_RS19225	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H5A30_RS19230	COG0750	zinc metalloprotease
H5A30_RS19235	COG0575	Belongs to the CDS family
H5A30_RS19240	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H5A30_RS19245	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
H5A30_RS19250	COG0233	cytoplasmic translational termination
H5A30_RS19255	COG0528	UMP kinase activity
H5A30_RS19260	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H5A30_RS19265	COG0052	Belongs to the universal ribosomal protein uS2 family
H5A30_RS19275	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
H5A30_RS19320	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H5A30_RS19320	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H5A30_RS19325	COG1611	Belongs to the LOG family
H5A30_RS19330	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H5A30_RS19335	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
H5A30_RS19340	COG2363	Small membrane protein
H5A30_RS19345	COG0583	DNA-binding transcription factor activity
H5A30_RS19355	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H5A30_RS19360	COG2166	iron-sulfur cluster assembly
H5A30_RS19365	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H5A30_RS19375	COG0747	negative chemotaxis
H5A30_RS19385	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H5A30_RS19390	COG4172	Belongs to the ABC transporter superfamily
H5A30_RS19395	COG1473	amidohydrolase
H5A30_RS19405	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H5A30_RS19410	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
H5A30_RS19430	COG0860	N-Acetylmuramoyl-L-alanine amidase
H5A30_RS19435	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
H5A30_RS19435	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H5A30_RS19445	COG1609	Transcriptional regulator
H5A30_RS19450	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H5A30_RS19455	COG1074	ATP-dependent DNA helicase activity
H5A30_RS19460	COG1025	Belongs to the peptidase M16 family
H5A30_RS19465	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
H5A30_RS19480	COG4795	General secretion pathway protein
H5A30_RS19485	COG4969	Belongs to the N-Me-Phe pilin family
H5A30_RS19490	COG1569	PIN domain
H5A30_RS19495	COG3311	Transcriptional regulator
H5A30_RS19500	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
H5A30_RS19505	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H5A30_RS19515	COG0494	nUDIX hydrolase
H5A30_RS19520	COG3066	DNA modification
H5A30_RS19525	COG0861	Integral membrane protein TerC family
H5A30_RS19535	COG0667	Aldo Keto reductase
H5A30_RS19540	COG3639	organic phosphonate transmembrane transporter activity
H5A30_RS19550	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
H5A30_RS19560	COG3454	Phosphonate metabolism
H5A30_RS19565	COG4778	phosphonate C-P lyase system protein PhnL
H5A30_RS19570	COG4107	phosphonate C-P lyase system protein PhnK
H5A30_RS19575	COG3627	carbon phosphorus lyase activity
H5A30_RS19580	COG3626	phosphonate metabolism
H5A30_RS19585	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
H5A30_RS19590	COG3624	Phosphonate C-P lyase system protein PhnG
H5A30_RS19595	COG2188	Transcriptional regulator
H5A30_RS19600	COG1404	Belongs to the peptidase S8 family
H5A30_RS19610	COG3171	Protein conserved in bacteria
H5A30_RS19615	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H5A30_RS19625	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
H5A30_RS19630	COG0741	lytic transglycosylase activity
H5A30_RS19635	COG1917	Cupin 2, conserved barrel domain protein
H5A30_RS19635	COG2169	Transcriptional regulator
H5A30_RS19645	COG5564	TIM-barrel signal transduction protein
H5A30_RS19650	COG5441	Belongs to the UPF0261 family
H5A30_RS19670	COG1982	Orn Lys Arg decarboxylase major
H5A30_RS19705	COG0583	DNA-binding transcription factor activity
H5A30_RS19755	COG0604	alcohol dehydrogenase
H5A30_RS19795	COG2003	Belongs to the UPF0758 family
H5A30_RS20045	COG0741	lytic transglycosylase activity
H5A30_RS20055	COG1459	type II secretion system
H5A30_RS20060	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H5A30_RS20100	COG0629	single-stranded DNA binding
H5A30_RS20110	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H5A30_RS20170	COG3547	Transposase (IS116 IS110 IS902 family)
H5A30_RS20180	COG1045	serine acetyltransferase
H5A30_RS20195	COG0438	transferase activity, transferring glycosyl groups
H5A30_RS20200	COG0297	glycogen (starch) synthase activity
H5A30_RS20245	COG2207	Transcriptional regulator
H5A30_RS20250	COG2814	Major facilitator Superfamily
H5A30_RS20255	COG1846	Transcriptional regulator
H5A30_RS20300	COG2249	NAD(P)H dehydrogenase (quinone) activity
H5A30_RS20365	COG3121	Chaperone
H5A30_RS20390	COG4948	Mandelate Racemase Muconate Lactonizing
H5A30_RS20395	COG4773	Receptor
H5A30_RS20405	COG0583	DNA-binding transcription factor activity
H5A30_RS20430	COG2814	Major facilitator Superfamily
H5A30_RS20450	COG0811	peptide transport
H5A30_RS20465	COG1802	Transcriptional regulator
H5A30_RS20470	COG0246	Mannitol dehydrogenase
H5A30_RS20475	COG0477	Major facilitator Superfamily
H5A30_RS20480	COG1063	alcohol dehydrogenase
H5A30_RS20485	COG4948	Mandelate Racemase Muconate Lactonizing
H5A30_RS20500	COG0583	DNA-binding transcription factor activity
H5A30_RS20510	COG0437	4 iron, 4 sulfur cluster binding
H5A30_RS20515	COG3301	Polysulphide reductase, NrfD
H5A30_RS20520	COG0477	Major facilitator Superfamily
H5A30_RS20525	COG0431	NADPH-dependent FMN reductase
H5A30_RS20525	COG1053	succinate dehydrogenase
H5A30_RS20525	COG3976	FMN-binding domain protein
H5A30_RS20540	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H5A30_RS20540	COG2169	Transcriptional regulator
H5A30_RS20565	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
H5A30_RS20565	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
H5A30_RS20570	COG3604	Transcriptional regulator
H5A30_RS20575	COG0426	domain, Protein
H5A30_RS20575	COG1773	rubredoxin
H5A30_RS20580	COG0446	pyridine nucleotide-disulphide oxidoreductase
H5A30_RS20590	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H5A30_RS20600	COG0531	amino acid
H5A30_RS20605	COG3115	cell septum assembly
H5A30_RS20610	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
H5A30_RS20620	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H5A30_RS20630	COG2190	(PTS) system
H5A30_RS20635	COG2205	protein histidine kinase activity
H5A30_RS20640	COG0745	RESPONSE REGULATOR receiver
H5A30_RS20645	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H5A30_RS20650	COG1136	(ABC) transporter
H5A30_RS20650	COG0577	efflux transmembrane transporter activity
H5A30_RS20655	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H5A30_RS20660	COG4208	sulfate ABC transporter
H5A30_RS20665	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
H5A30_RS20670	COG4150	thiosulfate binding
H5A30_RS20675	COG2837	iron assimilation
H5A30_RS20685	COG4178	(ABC) transporter
H5A30_RS20690	COG0612	Peptidase, M16
H5A30_RS20695	COG4771	TonB-dependent receptor
H5A30_RS20705	COG0456	acetyltransferase
H5A30_RS20710	COG0408	coproporphyrinogen oxidase activity
H5A30_RS20715	COG1671	Belongs to the UPF0178 family
H5A30_RS20720	COG0814	amino acid
H5A30_RS20735	COG2084	Dehydrogenase
H5A30_RS20740	COG1082	Xylose isomerase domain protein TIM barrel
H5A30_RS20745	COG0149	triose-phosphate isomerase activity
H5A30_RS20750	COG2376	Dihydroxyacetone kinase
H5A30_RS20760	COG0698	ribose 5-phosphate isomerase
H5A30_RS20765	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H5A30_RS20770	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H5A30_RS20775	COG1263	PTS System
H5A30_RS20775	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H5A30_RS20775	COG2190	(PTS) system
H5A30_RS20780	COG2723	6-phospho-beta-galactosidase activity
H5A30_RS20785	COG3711	transcriptional antiterminator
H5A30_RS20790	COG1609	Transcriptional regulator
H5A30_RS20820	COG0494	nUDIX hydrolase
H5A30_RS20830	COG0477	Major facilitator Superfamily
H5A30_RS20835	COG1942	4-Oxalocrotonate Tautomerase
H5A30_RS20840	COG1914	H( )-stimulated, divalent metal cation uptake system
H5A30_RS20845	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H5A30_RS20850	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H5A30_RS20855	COG0497	DNA recombination
H5A30_RS20865	COG2914	Belongs to the UPF0125 (RnfH) family
H5A30_RS20870	COG2867	negative regulation of translational initiation
H5A30_RS20875	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H5A30_RS20995	COG3566	protein conserved in bacteria
H5A30_RS21005	COG3567	Phage-associated protein, HI1409 family
H5A30_RS21010	COG5410	chromosome segregation
H5A30_RS21145	COG3756	Protein conserved in bacteria
H5A30_RS21185	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H5A30_RS21195	COG0582	viral genome integration into host DNA
H5A30_RS21225	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H5A30_RS21230	COG1280	lysine exporter protein (LysE YggA)
H5A30_RS21250	COG1013	pyruvate-flavodoxin oxidoreductase activity
H5A30_RS21250	COG0674	pyruvate-flavodoxin oxidoreductase activity
H5A30_RS21250	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
H5A30_RS21250	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H5A30_RS21255	COG3038	cytochrome b561
H5A30_RS21260	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H5A30_RS21265	COG1376	ErfK ybiS ycfS ynhG family protein
H5A30_RS21270	COG2873	o-acetylhomoserine
H5A30_RS21275	COG0246	Mannitol dehydrogenase
H5A30_RS21295	COG3712	iron ion homeostasis
H5A30_RS21305	COG4774	siderophore transport
H5A30_RS21315	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H5A30_RS21320	COG3162	membrane
H5A30_RS21325	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H5A30_RS21330	COG5464	transposase or invertase
H5A30_RS21410	COG4964	Belongs to the GSP D family
H5A30_RS21430	COG2205	protein histidine kinase activity
H5A30_RS21440	COG0025	NhaP-type Na H and K H
H5A30_RS21445	COG2252	PERMEase
H5A30_RS21470	COG1953	Uracil, thiamine, allantoin
H5A30_RS21475	COG1560	Kdo2-lipid A biosynthetic process
H5A30_RS21485	COG4319	ketosteroid isomerase
H5A30_RS21520	COG4974	Belongs to the 'phage' integrase family
H5A30_RS21540	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H5A30_RS21550	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H5A30_RS21555	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H5A30_RS21560	COG4974	Belongs to the 'phage' integrase family
H5A30_RS21565	COG0477	Major facilitator Superfamily
H5A30_RS21575	COG0716	FMN binding
H5A30_RS21585	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
H5A30_RS21595	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
H5A30_RS21600	COG0354	folic acid binding
H5A30_RS21605	COG1272	protein, Hemolysin III
H5A30_RS21625	COG2211	Major facilitator Superfamily
H5A30_RS21630	COG1653	transport
H5A30_RS21635	COG3842	ATPase activity
H5A30_RS21640	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H5A30_RS21650	COG1175	transmembrane transport
H5A30_RS21660	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H5A30_RS21660	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H5A30_RS21665	COG0509	glycine decarboxylation via glycine cleavage system
H5A30_RS21670	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H5A30_RS21675	COG1454	alcohol dehydrogenase
H5A30_RS21725	COG0656	L-ascorbic acid biosynthetic process
H5A30_RS21730	COG2813	Specifically methylates the guanine in position
H5A30_RS21735	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
H5A30_RS21740	COG0456	acetyltransferase
H5A30_RS21760	COG0583	DNA-binding transcription factor activity
H5A30_RS21765	COG1595	DNA-templated transcription, initiation
H5A30_RS21770	COG3712	iron ion homeostasis
H5A30_RS21780	COG4178	(ABC) transporter
H5A30_RS21800	COG0813	purine-nucleoside phosphorylase activity
H5A30_RS21805	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
H5A30_RS21810	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
H5A30_RS21815	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
H5A30_RS21820	COG1473	amidohydrolase
H5A30_RS21825	COG2827	Endonuclease containing a URI domain
H5A30_RS21830	COG3153	acetyltransferase
H5A30_RS21835	COG3154	lipid carrier protein
H5A30_RS21840	COG0826	peptidase U32
H5A30_RS21845	COG0826	peptidase U32
H5A30_RS21850	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H5A30_RS21855	COG0513	Belongs to the DEAD box helicase family
H5A30_RS21870	COG1185	polyribonucleotide nucleotidyltransferase activity
H5A30_RS21875	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H5A30_RS21880	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H5A30_RS21885	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H5A30_RS21890	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H5A30_RS21900	COG0779	Required for maturation of 30S ribosomal subunits
H5A30_RS21950	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H5A30_RS21955	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H5A30_RS21960	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H5A30_RS21965	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H5A30_RS21970	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
H5A30_RS21975	COG1534	Rna-binding protein
H5A30_RS21985	COG2027	D-alanyl-D-alanine carboxypeptidase
H5A30_RS21990	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H5A30_RS21995	COG0697	spore germination
H5A30_RS22000	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H5A30_RS22005	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H5A30_RS22010	COG0142	geranyltranstransferase activity
H5A30_RS22025	COG3423	Transcriptional regulator
H5A30_RS22030	COG0039	L-malate dehydrogenase activity
H5A30_RS22035	COG1438	arginine binding
H5A30_RS22040	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H5A30_RS22045	COG0828	Belongs to the bacterial ribosomal protein bS21 family
H5A30_RS22050	COG0358	DNA primase activity
H5A30_RS22060	COG3663	DNA glycosylase
H5A30_RS22070	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H5A30_RS22070	COG2755	lipolytic protein G-D-S-L family
H5A30_RS22075	COG0583	DNA-binding transcription factor activity
H5A30_RS22085	COG0243	molybdopterin cofactor binding
H5A30_RS22110	COG2199	diguanylate cyclase activity
H5A30_RS22115	COG3678	ATP-independent chaperone mediated protein folding
H5A30_RS22125	COG1902	pentaerythritol trinitrate reductase activity
H5A30_RS22125	COG0446	pyridine nucleotide-disulphide oxidoreductase
H5A30_RS22130	COG2813	Specifically methylates the guanine in position
H5A30_RS22135	COG0673	inositol 2-dehydrogenase activity
H5A30_RS22140	COG0861	Integral membrane protein TerC family
H5A30_RS22145	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
H5A30_RS22155	COG2721	sulfolactate sulfo-lyase activity
H5A30_RS22160	COG0246	Mannitol dehydrogenase
H5A30_RS22165	COG1904	glucuronate isomerase
H5A30_RS22170	COG2271	Major facilitator Superfamily
H5A30_RS22180	COG0586	Pfam SNARE associated Golgi protein
H5A30_RS22190	COG1422	Protein of unknown function (DUF1090)
H5A30_RS22195	COG4575	ribosome binding
H5A30_RS22200	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
H5A30_RS22210	COG2259	Doxx family
H5A30_RS22215	COG0435	Glutathione S-transferase
H5A30_RS22220	COG0583	DNA-binding transcription factor activity
H5A30_RS22225	COG1741	Belongs to the pirin family
H5A30_RS22230	COG0735	belongs to the Fur family
H5A30_RS22235	COG3237	CsbD-like
H5A30_RS22240	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H5A30_RS22245	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H5A30_RS22250	COG2937	Belongs to the GPAT DAPAT family
H5A30_RS22255	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H5A30_RS22260	COG3161	chorismate lyase activity
H5A30_RS22265	COG0459	protein refolding
H5A30_RS22270	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H5A30_RS22285	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
H5A30_RS22290	COG1324	tolerance protein
H5A30_RS22295	COG4232	protein-disulfide reductase activity
H5A30_RS22300	COG1309	transcriptional regulator
H5A30_RS22320	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
H5A30_RS22405	COG2003	Belongs to the UPF0758 family