locus-tag	class	description
NC16_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
NC16_RS00010	COG0592	DNA-directed DNA polymerase activity
NC16_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
NC16_RS00035	COG0840	transmembrane signaling receptor activity
NC16_RS00040	COG1609	Transcriptional regulator
NC16_RS00045	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NC16_RS00050	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NC16_RS00055	COG1447	Phosphotransferase system cellobiose-specific component IIA
NC16_RS00060	COG2723	6-phospho-beta-galactosidase activity
NC16_RS00070	COG0561	phosphatase activity
NC16_RS00080	COG0747	negative chemotaxis
NC16_RS00085	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NC16_RS00100	COG0601	transmembrane transport
NC16_RS00105	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NC16_RS00120	COG1116	anion transmembrane transporter activity
NC16_RS00125	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NC16_RS00130	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NC16_RS00135	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NC16_RS00145	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NC16_RS00145	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NC16_RS00150	COG2723	6-phospho-beta-galactosidase activity
NC16_RS00160	COG0823	Involved in the tonB-independent uptake of proteins
NC16_RS00165	COG5645	(Lipo)protein
NC16_RS00170	COG0071	Belongs to the small heat shock protein (HSP20) family
NC16_RS00175	COG0071	Belongs to the small heat shock protein (HSP20) family
NC16_RS00180	COG2985	domain, Protein
NC16_RS00180	COG0569	domain protein
NC16_RS00185	COG0471	metal ion transport
NC16_RS00190	COG3290	protein histidine kinase activity
NC16_RS00195	COG4565	transcriptional regulatory protein
NC16_RS00225	COG3493	citrate carrier protein
NC16_RS00230	COG0747	negative chemotaxis
NC16_RS00235	COG0601	transmembrane transport
NC16_RS00240	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NC16_RS00245	COG0444	Belongs to the ABC transporter superfamily
NC16_RS00250	COG4608	Belongs to the ABC transporter superfamily
NC16_RS00265	COG3209	COG3209 Rhs family protein
NC16_RS00265	COG4104	PAAR repeat-containing protein
NC16_RS00275	COG3209	COG3209 Rhs family protein
NC16_RS00275	COG4104	PAAR repeat-containing protein
NC16_RS00285	COG3501	Rhs element vgr protein
NC16_RS00295	COG3977	Valine--pyruvate aminotransferase
NC16_RS00315	COG3118	belongs to the thioredoxin family
NC16_RS00315	COG0457	Tetratricopeptide repeat
NC16_RS00320	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
NC16_RS00330	COG1215	transferase activity, transferring glycosyl groups
NC16_RS00335	COG1192	Involved in chromosome partitioning
NC16_RS00355	COG2194	sulfuric ester hydrolase activity
NC16_RS00360	COG2200	EAL domain
NC16_RS00360	COG2199	diguanylate cyclase activity
NC16_RS00365	COG1301	dicarboxylic acid transport
NC16_RS00370	COG0612	Peptidase, M16
NC16_RS00375	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NC16_RS00380	COG1295	ribonuclease BN
NC16_RS00385	COG0477	Major facilitator Superfamily
NC16_RS00395	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
NC16_RS00400	COG0425	Belongs to the sulfur carrier protein TusA family
NC16_RS00410	COG3714	YhhN family
NC16_RS00420	COG3776	membrane
NC16_RS00425	COG0742	ribosomal rna small subunit methyltransferase
NC16_RS00430	COG0552	protein localization to endoplasmic reticulum
NC16_RS00435	COG2884	Cell division ATP-binding protein ftsE
NC16_RS00440	COG2177	Part of the ABC transporter FtsEX involved in
NC16_RS00455	COG0683	leucine binding
NC16_RS00460	COG0559	Belongs to the binding-protein-dependent transport system permease family
NC16_RS00465	COG4177	L-phenylalanine transmembrane transporter activity
NC16_RS00470	COG0411	ABC transporter
NC16_RS00475	COG0410	ABC transporter
NC16_RS00480	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NC16_RS00485	COG0840	transmembrane signaling receptor activity
NC16_RS00490	COG0840	transmembrane signaling receptor activity
NC16_RS00495	COG0840	transmembrane signaling receptor activity
NC16_RS00500	COG0840	transmembrane signaling receptor activity
NC16_RS00505	COG2610	gluconate transmembrane transporter activity
NC16_RS00510	COG3622	Belongs to the hyi family
NC16_RS00515	COG0235	Class ii aldolase
NC16_RS00520	COG3395	kinase activity
NC16_RS00525	COG2084	Dehydrogenase
NC16_RS00530	COG1349	DNA-binding transcription factor activity
NC16_RS00565	COG3609	addiction module antidote protein, CC2985 family
NC16_RS00570	COG1653	transport
NC16_RS00575	COG1175	transmembrane transport
NC16_RS00580	COG0395	ABC-type sugar transport system, permease component
NC16_RS00585	COG3842	ATPase activity
NC16_RS00590	COG0584	glycerophosphoryl diester phosphodiesterase
NC16_RS00605	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
NC16_RS00620	COG2205	protein histidine kinase activity
NC16_RS00625	COG0745	RESPONSE REGULATOR receiver
NC16_RS00630	COG3678	ATP-independent chaperone mediated protein folding
NC16_RS00665	COG2814	Major facilitator Superfamily
NC16_RS00670	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
NC16_RS00675	COG0205	6-phosphofructokinase activity
NC16_RS00680	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NC16_RS00685	COG2957	Belongs to the agmatine deiminase family
NC16_RS00695	COG0149	triose-phosphate isomerase activity
NC16_RS00705	COG3152	Membrane
NC16_RS00715	COG1494	fructose-1,6-bisphosphatase
NC16_RS00725	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NC16_RS00730	COG3074	FtsZ-dependent cytokinesis
NC16_RS00735	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
NC16_RS00740	COG1575	Belongs to the MenA family. Type 1 subfamily
NC16_RS00745	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
NC16_RS00750	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
NC16_RS00755	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
NC16_RS00760	COG1609	Transcriptional regulator
NC16_RS00765	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
NC16_RS00770	COG0254	rRNA binding
NC16_RS00775	COG1598	PFAM Uncharacterised protein family UPF0150
NC16_RS00785	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NC16_RS00795	COG1120	ATPase activity
NC16_RS00800	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
NC16_RS00805	COG0626	cystathionine gamma-synthase activity
NC16_RS00810	COG0527	aspartate kinase activity
NC16_RS00810	COG0460	homoserine dehydrogenase
NC16_RS00815	COG3842	ATPase activity
NC16_RS00830	COG0395	ABC-type sugar transport system, permease component
NC16_RS00835	COG1609	Transcriptional regulator
NC16_RS00840	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
NC16_RS00855	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NC16_RS00870	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NC16_RS00880	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
NC16_RS00905	COG0812	UDP-N-acetylmuramate dehydrogenase activity
NC16_RS00910	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
NC16_RS00910	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
NC16_RS00915	COG1072	(Pantothenic acid kinase))
NC16_RS00955	COG0250	Participates in transcription elongation, termination and antitermination
NC16_RS00960	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
NC16_RS00965	COG0081	regulation of translation
NC16_RS00970	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
NC16_RS00975	COG0222	ribosome binding
NC16_RS00980	COG0085	RNA polymerase activity
NC16_RS00985	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
NC16_RS00990	COG0477	Major facilitator Superfamily
NC16_RS00995	COG5457	Domain of unknown function (DUF1127)
NC16_RS01000	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NC16_RS01010	COG2022	thiamine diphosphate biosynthetic process
NC16_RS01015	COG2104	thiamine diphosphate biosynthetic process
NC16_RS01020	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
NC16_RS01025	COG0352	thiamine-phosphate diphosphorylase activity
NC16_RS01030	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
NC16_RS01035	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
NC16_RS01040	COG2816	NAD+ diphosphatase activity
NC16_RS01045	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
NC16_RS01050	COG1515	deoxyribonuclease V activity
NC16_RS01070	COG0151	Belongs to the GarS family
NC16_RS01075	COG0138	bifunctional purine biosynthesis protein purh
NC16_RS01105	COG1126	abc transporter atp-binding protein
NC16_RS01110	COG0765	amino acid transport
NC16_RS01115	COG4597	amino acid ABC transporter
NC16_RS01120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NC16_RS01125	COG0765	amino acid transport
NC16_RS01130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NC16_RS01145	COG2226	methyltransferase
NC16_RS01155	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
NC16_RS01170	COG2264	protein methyltransferase activity
NC16_RS01175	COG4145	pantothenate transmembrane transporter activity
NC16_RS01180	COG3924	membrane
NC16_RS01185	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NC16_RS01190	COG2207	Transcriptional regulator
NC16_RS01195	COG0439	Biotin carboxylase
NC16_RS01200	COG0511	ligase activity, forming carbon-carbon bonds
NC16_RS01205	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
NC16_RS01210	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
NC16_RS01215	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
NC16_RS01220	COG0604	alcohol dehydrogenase
NC16_RS01225	COG2199	diguanylate cyclase activity
NC16_RS01225	COG2200	EAL domain
NC16_RS01230	COG1077	Cell shape determining protein MreB Mrl
NC16_RS01235	COG1792	Involved in formation and maintenance of cell shape
NC16_RS01240	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
NC16_RS01245	COG0424	maF-like protein
NC16_RS01250	COG1530	ribonuclease E activity
NC16_RS01255	COG3164	Protein of unknown function
NC16_RS01260	COG0312	modulator of DNA gyrase
NC16_RS01275	COG0583	DNA-binding transcription factor activity
NC16_RS01285	COG1566	PFAM secretion protein HlyD family protein
NC16_RS01290	COG1289	transmembrane transporter activity
NC16_RS01300	COG3028	Belongs to the UPF0307 family
NC16_RS01305	COG0312	modulator of DNA gyrase
NC16_RS01310	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NC16_RS01315	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NC16_RS01320	COG1660	Displays ATPase and GTPase activities
NC16_RS01325	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NC16_RS01330	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
NC16_RS01335	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
NC16_RS01340	COG1137	ATPase activity
NC16_RS01345	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
NC16_RS01350	COG3117	lipopolysaccharide transmembrane transporter activity
NC16_RS01355	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
NC16_RS01360	COG0517	IMP dehydrogenase activity
NC16_RS01360	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
NC16_RS01365	COG0530	calcium, potassium:sodium antiporter activity
NC16_RS01370	COG1127	ABC transporter
NC16_RS01375	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
NC16_RS01380	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
NC16_RS01385	COG2854	intermembrane phospholipid transfer
NC16_RS01390	COG3113	response to antibiotic
NC16_RS01395	COG5007	Belongs to the BolA IbaG family
NC16_RS01400	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NC16_RS01405	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NC16_RS01410	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NC16_RS01415	COG3105	Protein conserved in bacteria
NC16_RS01420	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
NC16_RS01430	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
NC16_RS01435	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
NC16_RS01440	COG0625	glutathione transferase activity
NC16_RS01445	COG2969	positive regulation of protein catabolic process
NC16_RS01455	COG0493	'glutamate synthase
NC16_RS01460	COG0070	glutamate synthase
NC16_RS01460	COG0069	glutamate synthase activity
NC16_RS01460	COG0067	glutamate synthase
NC16_RS01465	COG1242	4 iron, 4 sulfur cluster binding
NC16_RS01470	COG0784	Response regulator, receiver
NC16_RS01470	COG2198	Histidine kinase
NC16_RS01470	COG5002	protein histidine kinase activity
NC16_RS01475	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
NC16_RS01480	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NC16_RS01490	COG2823	Periplasmic or secreted lipoprotein
NC16_RS01495	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
NC16_RS01500	COG0792	nuclease activity
NC16_RS01505	COG3107	peptidoglycan biosynthetic process
NC16_RS01510	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
NC16_RS01540	COG3384	dioxygenase
NC16_RS01550	COG0754	glutathionylspermidine amidase activity
NC16_RS01555	COG5463	Belongs to the UPF0441 family
NC16_RS01565	COG0494	nUDIX hydrolase
NC16_RS01570	COG3151	Protein conserved in bacteria
NC16_RS01575	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
NC16_RS01580	COG3150	esterase
NC16_RS01585	COG0187	DNA topoisomerase II activity
NC16_RS01590	COG0583	DNA-binding transcription factor activity
NC16_RS01595	COG2249	NAD(P)H dehydrogenase (quinone) activity
NC16_RS01610	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NC16_RS01610	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NC16_RS01615	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NC16_RS01620	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NC16_RS01620	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NC16_RS01620	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NC16_RS01625	COG3711	transcriptional antiterminator
NC16_RS01625	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NC16_RS01630	COG4771	TonB-dependent receptor
NC16_RS01630	COG1629	transport
NC16_RS01640	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NC16_RS01645	COG0204	Acyl-transferase
NC16_RS01650	COG2132	Multicopper oxidase
NC16_RS01655	COG2188	Transcriptional regulator
NC16_RS01665	COG1979	alcohol dehydrogenase
NC16_RS01670	COG0778	Nitroreductase
NC16_RS01675	COG2207	Transcriptional regulator
NC16_RS01680	COG0586	Pfam SNARE associated Golgi protein
NC16_RS01685	COG0626	cystathionine gamma-synthase activity
NC16_RS01700	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
NC16_RS01710	COG0848	biopolymer transport protein
NC16_RS01760	COG0076	glutamate decarboxylase activity
NC16_RS01765	COG2814	Major facilitator Superfamily
NC16_RS01775	COG3787	Belongs to the UPF0306 family
NC16_RS01780	COG0702	epimerase
NC16_RS01800	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
NC16_RS01805	COG0540	Belongs to the ATCase OTCase family
NC16_RS01810	COG2731	YhcH YjgK YiaL family protein
NC16_RS01815	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
NC16_RS01835	COG0501	Belongs to the peptidase M48B family
NC16_RS01840	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NC16_RS01845	COG0840	transmembrane signaling receptor activity
NC16_RS01850	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
NC16_RS01855	COG0525	valine-tRNA ligase activity
NC16_RS01860	COG2927	DNA polymerase III (CHI subunit)
NC16_RS01865	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
NC16_RS01870	COG0795	lipopolysaccharide-transporting ATPase activity
NC16_RS01875	COG0795	lipopolysaccharide-transporting ATPase activity
NC16_RS01940	COG0582	viral genome integration into host DNA
NC16_RS01960	COG2850	peptidyl-arginine hydroxylation
NC16_RS01975	COG0583	DNA-binding transcription factor activity
NC16_RS01985	COG1401	restriction endodeoxyribonuclease activity
NC16_RS01995	COG4650	regulator
NC16_RS02020	COG0659	secondary active sulfate transmembrane transporter activity
NC16_RS02025	COG0288	reversible hydration of carbon dioxide
NC16_RS02030	COG0840	transmembrane signaling receptor activity
NC16_RS02040	COG0840	transmembrane signaling receptor activity
NC16_RS02045	COG3254	rhamnose metabolic process
NC16_RS02050	COG0235	Class ii aldolase
NC16_RS02055	COG4806	L-rhamnose isomerase
NC16_RS02060	COG1070	Carbohydrate kinase
NC16_RS02065	COG2169	Transcriptional regulator
NC16_RS02065	COG1917	Cupin 2, conserved barrel domain protein
NC16_RS02070	COG1917	Cupin 2, conserved barrel domain protein
NC16_RS02070	COG4977	sequence-specific DNA binding
NC16_RS02075	COG4115	mRNA cleavage
NC16_RS02080	COG2161	toxin-antitoxin pair type II binding
NC16_RS02090	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NC16_RS02095	COG0601	transmembrane transport
NC16_RS02100	COG0747	negative chemotaxis
NC16_RS02105	COG3477	response to acidic pH
NC16_RS02125	COG2862	Uncharacterized protein family, UPF0114
NC16_RS02130	COG2130	NADP-dependent
NC16_RS02165	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NC16_RS02170	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NC16_RS02175	COG0006	proline dipeptidase activity
NC16_RS02180	COG3079	Belongs to the UPF0149 family
NC16_RS02185	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
NC16_RS02195	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
NC16_RS02210	COG0560	Phosphoserine phosphatase
NC16_RS02215	COG3726	membrane protein affecting hemolysin expression
NC16_RS02225	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
NC16_RS02230	COG2823	Periplasmic or secreted lipoprotein
NC16_RS02235	COG5487	UPF0391 membrane protein
NC16_RS02245	COG0084	hydrolase, TatD family'
NC16_RS02250	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NC16_RS02260	COG4771	TonB-dependent receptor
NC16_RS02270	COG1169	isochorismate synthase
NC16_RS02275	COG1021	2,3-dihydroxybenzoate-AMP ligase
NC16_RS02280	COG3433	isochorismatase activity
NC16_RS02280	COG1535	isochorismatase
NC16_RS02285	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NC16_RS02290	COG1028	Short-chain dehydrogenase reductase Sdr
NC16_RS02300	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NC16_RS02300	COG3321	synthase
NC16_RS02300	COG0318	PFAM AMP-dependent synthetase and ligase
NC16_RS02300	COG0300	oxidoreductase activity
NC16_RS02300	COG1028	Short-chain dehydrogenase reductase Sdr
NC16_RS02305	COG3547	Transposase (IS116 IS110 IS902 family)
NC16_RS02320	COG3627	carbon phosphorus lyase activity
NC16_RS02325	COG4107	phosphonate C-P lyase system protein PhnK
NC16_RS02330	COG4778	phosphonate C-P lyase system protein PhnL
NC16_RS02335	COG3454	Phosphonate metabolism
NC16_RS02340	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
NC16_RS02345	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
NC16_RS02385	COG3423	Transcriptional regulator
NC16_RS02390	COG3385	transposase activity
NC16_RS02435	COG0582	viral genome integration into host DNA
NC16_RS02455	COG1309	transcriptional regulator
NC16_RS02460	COG4232	protein-disulfide reductase activity
NC16_RS02465	COG1324	tolerance protein
NC16_RS02470	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
NC16_RS02485	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
NC16_RS02490	COG0459	protein refolding
NC16_RS02495	COG3161	chorismate lyase activity
NC16_RS02500	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
NC16_RS02505	COG2937	Belongs to the GPAT DAPAT family
NC16_RS02510	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
NC16_RS02515	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
NC16_RS02520	COG3237	CsbD-like
NC16_RS02525	COG0735	belongs to the Fur family
NC16_RS02530	COG1741	Belongs to the pirin family
NC16_RS02535	COG0583	DNA-binding transcription factor activity
NC16_RS02540	COG0435	Glutathione S-transferase
NC16_RS02545	COG2259	Doxx family
NC16_RS02555	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
NC16_RS02560	COG4575	ribosome binding
NC16_RS02565	COG1422	Protein of unknown function (DUF1090)
NC16_RS02575	COG0586	Pfam SNARE associated Golgi protein
NC16_RS02585	COG2271	Major facilitator Superfamily
NC16_RS02590	COG1904	glucuronate isomerase
NC16_RS02595	COG0246	Mannitol dehydrogenase
NC16_RS02600	COG2721	sulfolactate sulfo-lyase activity
NC16_RS02610	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
NC16_RS02615	COG0861	Integral membrane protein TerC family
NC16_RS02620	COG0673	inositol 2-dehydrogenase activity
NC16_RS02625	COG2813	Specifically methylates the guanine in position
NC16_RS02630	COG1902	pentaerythritol trinitrate reductase activity
NC16_RS02630	COG0446	pyridine nucleotide-disulphide oxidoreductase
NC16_RS02640	COG3678	ATP-independent chaperone mediated protein folding
NC16_RS02645	COG2199	diguanylate cyclase activity
NC16_RS02675	COG0583	DNA-binding transcription factor activity
NC16_RS02775	COG3663	DNA glycosylase
NC16_RS02785	COG0358	DNA primase activity
NC16_RS02790	COG0828	Belongs to the bacterial ribosomal protein bS21 family
NC16_RS02795	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
NC16_RS02800	COG1438	arginine binding
NC16_RS02805	COG0039	L-malate dehydrogenase activity
NC16_RS02810	COG3423	Transcriptional regulator
NC16_RS02825	COG0142	geranyltranstransferase activity
NC16_RS02830	COG0261	This protein binds to 23S rRNA in the presence of protein L20
NC16_RS02835	COG0211	Belongs to the bacterial ribosomal protein bL27 family
NC16_RS02840	COG0697	spore germination
NC16_RS02845	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
NC16_RS02850	COG2027	D-alanyl-D-alanine carboxypeptidase
NC16_RS02860	COG1534	Rna-binding protein
NC16_RS02865	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
NC16_RS02870	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NC16_RS02880	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
NC16_RS02885	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NC16_RS02895	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
NC16_RS02905	COG2130	NADP-dependent
NC16_RS02915	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NC16_RS02970	COG2197	response regulator
NC16_RS02980	COG0779	Required for maturation of 30S ribosomal subunits
NC16_RS02990	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
NC16_RS02995	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
NC16_RS03000	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
NC16_RS03005	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
NC16_RS03010	COG1185	polyribonucleotide nucleotidyltransferase activity
NC16_RS03020	COG0513	Belongs to the DEAD box helicase family
NC16_RS03025	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NC16_RS03030	COG0826	peptidase U32
NC16_RS03035	COG0826	peptidase U32
NC16_RS03040	COG3154	lipid carrier protein
NC16_RS03045	COG3153	acetyltransferase
NC16_RS03050	COG2827	Endonuclease containing a URI domain
NC16_RS03055	COG1473	amidohydrolase
NC16_RS03060	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
NC16_RS03065	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
NC16_RS03070	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
NC16_RS03075	COG0813	purine-nucleoside phosphorylase activity
NC16_RS03080	COG4178	(ABC) transporter
NC16_RS03090	COG3712	iron ion homeostasis
NC16_RS03095	COG1595	DNA-templated transcription, initiation
NC16_RS03100	COG0583	DNA-binding transcription factor activity
NC16_RS03120	COG0456	acetyltransferase
NC16_RS03125	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
NC16_RS03130	COG2813	Specifically methylates the guanine in position
NC16_RS03135	COG0656	L-ascorbic acid biosynthetic process
NC16_RS03190	COG1454	alcohol dehydrogenase
NC16_RS03195	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NC16_RS03200	COG0509	glycine decarboxylation via glycine cleavage system
NC16_RS03205	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NC16_RS03205	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NC16_RS03220	COG1175	transmembrane transport
NC16_RS03230	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
NC16_RS03235	COG3842	ATPase activity
NC16_RS03240	COG1653	transport
NC16_RS03245	COG2211	Major facilitator Superfamily
NC16_RS03265	COG1272	protein, Hemolysin III
NC16_RS03270	COG0354	folic acid binding
NC16_RS03275	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
NC16_RS03285	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
NC16_RS03295	COG0716	FMN binding
NC16_RS03305	COG0477	Major facilitator Superfamily
NC16_RS03310	COG4974	Belongs to the 'phage' integrase family
NC16_RS03315	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NC16_RS03320	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
NC16_RS03330	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
NC16_RS03350	COG0582	viral genome integration into host DNA
NC16_RS03360	COG2336	PFAM SpoVT AbrB
NC16_RS03400	COG1560	Kdo2-lipid A biosynthetic process
NC16_RS03405	COG1953	Uracil, thiamine, allantoin
NC16_RS03435	COG2252	PERMEase
NC16_RS03445	COG0025	NhaP-type Na H and K H
NC16_RS03455	COG5002	protein histidine kinase activity
NC16_RS03455	COG3850	Histidine kinase
NC16_RS03475	COG4964	Belongs to the GSP D family
NC16_RS03565	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NC16_RS03570	COG3162	membrane
NC16_RS03575	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NC16_RS03590	COG4774	siderophore transport
NC16_RS03600	COG3712	iron ion homeostasis
NC16_RS03620	COG0246	Mannitol dehydrogenase
NC16_RS03625	COG2873	o-acetylhomoserine
NC16_RS03630	COG1376	ErfK ybiS ycfS ynhG family protein
NC16_RS03635	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NC16_RS03640	COG3038	cytochrome b561
NC16_RS03645	COG0674	pyruvate-flavodoxin oxidoreductase activity
NC16_RS03645	COG1013	pyruvate-flavodoxin oxidoreductase activity
NC16_RS03645	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
NC16_RS03645	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NC16_RS03665	COG1280	lysine exporter protein (LysE YggA)
NC16_RS03670	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NC16_RS03685	COG3012	SEC-C Motif Domain Protein
NC16_RS03690	COG0582	viral genome integration into host DNA
NC16_RS03725	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
NC16_RS03730	COG2867	negative regulation of translational initiation
NC16_RS03735	COG2914	Belongs to the UPF0125 (RnfH) family
NC16_RS03755	COG0497	DNA recombination
NC16_RS03760	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NC16_RS03765	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
NC16_RS03770	COG1914	H( )-stimulated, divalent metal cation uptake system
NC16_RS03775	COG1942	4-Oxalocrotonate Tautomerase
NC16_RS03780	COG0477	Major facilitator Superfamily
NC16_RS03790	COG0494	nUDIX hydrolase
NC16_RS03820	COG1609	Transcriptional regulator
NC16_RS03825	COG3711	transcriptional antiterminator
NC16_RS03830	COG2723	6-phospho-beta-galactosidase activity
NC16_RS03835	COG1263	PTS System
NC16_RS03835	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NC16_RS03835	COG2190	(PTS) system
NC16_RS03840	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
NC16_RS03845	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NC16_RS03850	COG0698	ribose 5-phosphate isomerase
NC16_RS03860	COG2376	Dihydroxyacetone kinase
NC16_RS03865	COG0149	triose-phosphate isomerase activity
NC16_RS03870	COG1082	Xylose isomerase domain protein TIM barrel
NC16_RS03875	COG2084	Dehydrogenase
NC16_RS03890	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
NC16_RS03895	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NC16_RS03900	COG0698	ribose 5-phosphate isomerase
NC16_RS03910	COG2376	Dihydroxyacetone kinase
NC16_RS03915	COG0149	triose-phosphate isomerase activity
NC16_RS03920	COG1082	Xylose isomerase domain protein TIM barrel
NC16_RS03925	COG2084	Dehydrogenase
NC16_RS03955	COG0814	amino acid
NC16_RS03960	COG1671	Belongs to the UPF0178 family
NC16_RS03965	COG0408	coproporphyrinogen oxidase activity
NC16_RS03970	COG0456	acetyltransferase
NC16_RS03985	COG4771	TonB-dependent receptor
NC16_RS03990	COG0612	Peptidase, M16
NC16_RS03995	COG4178	(ABC) transporter
NC16_RS04010	COG2837	iron assimilation
NC16_RS04015	COG4150	thiosulfate binding
NC16_RS04020	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
NC16_RS04025	COG4208	sulfate ABC transporter
NC16_RS04030	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NC16_RS04035	COG1136	(ABC) transporter
NC16_RS04035	COG0577	efflux transmembrane transporter activity
NC16_RS04040	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NC16_RS04045	COG0745	RESPONSE REGULATOR receiver
NC16_RS04050	COG2205	protein histidine kinase activity
NC16_RS04055	COG2190	(PTS) system
NC16_RS04065	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NC16_RS04075	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
NC16_RS04080	COG3115	cell septum assembly
NC16_RS04085	COG0531	amino acid
NC16_RS04095	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NC16_RS04105	COG0446	pyridine nucleotide-disulphide oxidoreductase
NC16_RS04110	COG0426	domain, Protein
NC16_RS04110	COG1773	rubredoxin
NC16_RS04115	COG3604	Transcriptional regulator
NC16_RS04120	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
NC16_RS04120	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
NC16_RS04145	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
NC16_RS04145	COG2169	Transcriptional regulator
NC16_RS04160	COG3976	FMN-binding domain protein
NC16_RS04160	COG0431	NADPH-dependent FMN reductase
NC16_RS04160	COG1053	succinate dehydrogenase
NC16_RS04165	COG0477	Major facilitator Superfamily
NC16_RS04170	COG3301	Polysulphide reductase, NrfD
NC16_RS04175	COG0437	4 iron, 4 sulfur cluster binding
NC16_RS04185	COG0583	DNA-binding transcription factor activity
NC16_RS04190	COG4948	Mandelate Racemase Muconate Lactonizing
NC16_RS04195	COG1063	alcohol dehydrogenase
NC16_RS04200	COG0477	Major facilitator Superfamily
NC16_RS04205	COG0246	Mannitol dehydrogenase
NC16_RS04210	COG1802	Transcriptional regulator
NC16_RS04220	COG2814	Major facilitator Superfamily
NC16_RS04240	COG0583	DNA-binding transcription factor activity
NC16_RS04250	COG4773	Receptor
NC16_RS04255	COG4948	Mandelate Racemase Muconate Lactonizing
NC16_RS04265	COG1129	ABC transporter
NC16_RS04285	COG3121	Chaperone
NC16_RS04355	COG1846	Transcriptional regulator
NC16_RS04360	COG2814	Major facilitator Superfamily
NC16_RS04365	COG2207	Transcriptional regulator
NC16_RS04420	COG3423	Transcriptional regulator
NC16_RS04430	COG1982	Orn Lys Arg decarboxylase major
NC16_RS04450	COG5441	Belongs to the UPF0261 family
NC16_RS04455	COG5564	TIM-barrel signal transduction protein
NC16_RS04465	COG2169	Transcriptional regulator
NC16_RS04465	COG1917	Cupin 2, conserved barrel domain protein
NC16_RS04470	COG0741	lytic transglycosylase activity
NC16_RS04475	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
NC16_RS04485	COG0220	tRNA (guanine-N7-)-methyltransferase activity
NC16_RS04490	COG3171	Protein conserved in bacteria
NC16_RS04500	COG1404	Belongs to the peptidase S8 family
NC16_RS04505	COG2188	Transcriptional regulator
NC16_RS04510	COG3624	Phosphonate C-P lyase system protein PhnG
NC16_RS04515	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
NC16_RS04520	COG3626	phosphonate metabolism
NC16_RS04525	COG3627	carbon phosphorus lyase activity
NC16_RS04530	COG4107	phosphonate C-P lyase system protein PhnK
NC16_RS04535	COG4778	phosphonate C-P lyase system protein PhnL
NC16_RS04540	COG3454	Phosphonate metabolism
NC16_RS04550	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
NC16_RS04560	COG3639	organic phosphonate transmembrane transporter activity
NC16_RS04565	COG0667	Aldo Keto reductase
NC16_RS04580	COG0861	Integral membrane protein TerC family
NC16_RS04585	COG3066	DNA modification
NC16_RS04595	COG0494	nUDIX hydrolase
NC16_RS04605	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
NC16_RS04610	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
NC16_RS04620	COG4969	Belongs to the N-Me-Phe pilin family
NC16_RS04625	COG4795	General secretion pathway protein
NC16_RS04640	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
NC16_RS04645	COG1025	Belongs to the peptidase M16 family
NC16_RS04650	COG1074	ATP-dependent DNA helicase activity
NC16_RS04655	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NC16_RS04660	COG1609	Transcriptional regulator
NC16_RS04670	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
NC16_RS04670	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
NC16_RS04675	COG0860	N-Acetylmuramoyl-L-alanine amidase
NC16_RS04695	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
NC16_RS04700	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NC16_RS04710	COG1473	amidohydrolase
NC16_RS04715	COG4172	Belongs to the ABC transporter superfamily
NC16_RS04720	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NC16_RS04730	COG0747	negative chemotaxis
NC16_RS04740	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
NC16_RS04745	COG2166	iron-sulfur cluster assembly
NC16_RS04750	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NC16_RS04760	COG0583	DNA-binding transcription factor activity
NC16_RS04765	COG2363	Small membrane protein
NC16_RS04770	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
NC16_RS04775	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NC16_RS04780	COG1611	Belongs to the LOG family
NC16_RS04790	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
NC16_RS04790	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
NC16_RS04830	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
NC16_RS04840	COG0052	Belongs to the universal ribosomal protein uS2 family
NC16_RS04845	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
NC16_RS04850	COG0528	UMP kinase activity
NC16_RS04855	COG0233	cytoplasmic translational termination
NC16_RS04860	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
NC16_RS04865	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NC16_RS04870	COG0575	Belongs to the CDS family
NC16_RS04875	COG0750	zinc metalloprotease
NC16_RS04880	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NC16_RS04885	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
NC16_RS04890	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NC16_RS04895	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
NC16_RS04900	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NC16_RS04905	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NC16_RS04910	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
NC16_RS04915	COG0587	DNA-directed DNA polymerase activity
NC16_RS04920	COG0825	malonyl-CoA metabolic process
NC16_RS04925	COG0346	lactoylglutathione lyase activity
NC16_RS04930	COG0037	tRNA processing
NC16_RS04935	COG4568	rho-dependent transcription termination
NC16_RS04950	COG3015	lipoprotein NlpE involved in copper resistance
NC16_RS04955	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
NC16_RS05005	COG1120	ATPase activity
NC16_RS05010	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NC16_RS05015	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NC16_RS05020	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
NC16_RS05025	COG4772	TonB-dependent receptor
NC16_RS05030	COG3712	iron ion homeostasis
NC16_RS05035	COG1595	DNA-templated transcription, initiation
NC16_RS05040	COG4943	cyclic-guanylate-specific phosphodiesterase activity
NC16_RS05045	COG2824	Alkylphosphonate utilization operon protein PhnA
NC16_RS05050	COG2951	lytic endotransglycosylase activity
NC16_RS05060	COG0583	DNA-binding transcription factor activity
NC16_RS05090	COG2186	Transcriptional regulator
NC16_RS05100	COG1312	Catalyzes the dehydration of D-mannonate
NC16_RS05105	COG5297	Belongs to the glycosyl hydrolase family 6
NC16_RS05140	COG4615	Cyclic peptide transporter
NC16_RS05150	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
NC16_RS05155	COG3123	guanosine phosphorylase activity
NC16_RS05165	COG2974	May be involved in recombination
NC16_RS05170	COG1940	carbohydrate kinase activity
NC16_RS05175	COG0419	ATPase involved in DNA repair
NC16_RS05180	COG0420	3'-5' exonuclease activity
NC16_RS05205	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
NC16_RS05215	COG1114	Component of the transport system for branched-chain amino acids
NC16_RS05225	COG0668	transmembrane transport
NC16_RS05230	COG0450	alkyl hydroperoxide reductase
NC16_RS05235	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
NC16_RS05240	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
NC16_RS05245	COG0343	queuine tRNA-ribosyltransferase activity
NC16_RS05250	COG1862	Preprotein translocase
NC16_RS05255	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NC16_RS05260	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NC16_RS05265	COG4238	major outer membrane lipoprotein
NC16_RS05270	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
NC16_RS05275	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NC16_RS05275	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NC16_RS05280	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
NC16_RS05285	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NC16_RS05290	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
NC16_RS05295	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
NC16_RS05300	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
NC16_RS05305	COG0142	geranyltranstransferase activity
NC16_RS05310	COG1722	exodeoxyribonuclease VII activity
NC16_RS05315	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NC16_RS05315	COG0301	tRNA thio-modification
NC16_RS05325	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
NC16_RS05330	COG1666	GTP binding
NC16_RS05335	COG2814	Major facilitator Superfamily
NC16_RS05340	COG0109	protoheme IX farnesyltransferase activity
NC16_RS05345	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
NC16_RS05350	COG1845	cytochrome c oxidase, subunit III
NC16_RS05355	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NC16_RS05360	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
NC16_RS05365	COG2223	nitrite transmembrane transporter activity
NC16_RS05370	COG3056	Lipoprotein
NC16_RS05375	COG0271	Belongs to the BolA IbaG family
NC16_RS05380	COG0544	peptidyl-prolyl cis-trans isomerase activity
NC16_RS05385	COG0740	serine-type endopeptidase activity
NC16_RS05390	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
NC16_RS05395	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
NC16_RS05400	COG0776	regulation of translation
NC16_RS05405	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NC16_RS05410	COG1555	photosystem II stabilization
NC16_RS05415	COG0824	Thioesterase
NC16_RS05420	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
NC16_RS05425	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NC16_RS05435	COG1522	sequence-specific DNA binding
NC16_RS05440	COG1132	(ABC) transporter
NC16_RS05445	COG1132	(ABC) transporter
NC16_RS05450	COG0347	Belongs to the P(II) protein family
NC16_RS05455	COG0004	ammonium transporteR
NC16_RS05460	COG1946	Acyl-CoA thioesterase
NC16_RS05465	COG3126	Type III secretion system lipoprotein chaperone (YscW)
NC16_RS05470	COG3695	enzyme binding
NC16_RS05490	COG0257	Belongs to the bacterial ribosomal protein bL36 family
NC16_RS05495	COG0254	rRNA binding
NC16_RS05500	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NC16_RS05505	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NC16_RS05510	COG1309	transcriptional regulator
NC16_RS05525	COG2832	Protein of unknown function (DUF454)
NC16_RS05530	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NC16_RS05540	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
NC16_RS05545	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
NC16_RS05550	COG0326	Molecular chaperone. Has ATPase activity
NC16_RS05555	COG0563	adenylate kinase activity
NC16_RS05560	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
NC16_RS05565	COG4651	solute:proton antiporter activity
NC16_RS05565	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NC16_RS05570	COG0737	Belongs to the 5'-nucleotidase family
NC16_RS05590	COG1966	Carbon starvation protein
NC16_RS05595	COG2879	small protein
NC16_RS05600	COG0523	cobalamin synthesis protein
NC16_RS05605	COG5434	Belongs to the glycosyl hydrolase 28 family
NC16_RS05615	COG3735	TraB family
NC16_RS05630	COG2217	Heavy metal translocating P-type atpase
NC16_RS05640	COG1585	Membrane protein implicated in regulation of membrane protease activity
NC16_RS05645	COG0330	HflC and HflK could
NC16_RS05650	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NC16_RS05655	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NC16_RS05660	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NC16_RS05665	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NC16_RS05675	COG0784	Response regulator, receiver
NC16_RS05675	COG2205	protein histidine kinase activity
NC16_RS05680	COG2197	response regulator
NC16_RS05685	COG0642	Histidine kinase
NC16_RS05685	COG2198	Histidine kinase
NC16_RS05690	COG2223	nitrite transmembrane transporter activity
NC16_RS05695	COG1169	isochorismate synthase
NC16_RS05700	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
NC16_RS05705	COG0596	Alpha beta hydrolase
NC16_RS05710	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
NC16_RS05715	COG1441	menaquinone biosynthetic process
NC16_RS05735	COG0814	amino acid
NC16_RS05745	COG3547	Transposase (IS116 IS110 IS902 family)
NC16_RS05750	COG3118	belongs to the thioredoxin family
NC16_RS05755	COG0300	oxidoreductase activity
NC16_RS05760	COG2755	lipolytic protein G-D-S-L family
NC16_RS05765	COG4181	ATPase activity
NC16_RS05770	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
NC16_RS05780	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NC16_RS05790	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NC16_RS05795	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
NC16_RS05800	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
NC16_RS05805	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
NC16_RS05815	COG2233	PERMEase
NC16_RS05820	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
NC16_RS05825	COG1393	Belongs to the ArsC family
NC16_RS05830	COG4783	chaperone-mediated protein folding
NC16_RS05835	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
NC16_RS05840	COG2716	regulation of RNA biosynthetic process
NC16_RS05850	COG0662	Cupin 2, conserved barrel domain protein
NC16_RS05860	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
NC16_RS05865	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
NC16_RS05870	COG2707	UPF0756 membrane protein
NC16_RS05875	COG1444	tRNA N-acetyltransferase activity
NC16_RS05885	COG3813	Protein conserved in bacteria
NC16_RS05890	COG0400	carboxylic ester hydrolase activity
NC16_RS05905	COG1876	peptidase activity
NC16_RS05910	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NC16_RS05915	COG1393	Belongs to the ArsC family
NC16_RS05925	COG1794	racemase activity, acting on amino acids and derivatives
NC16_RS05935	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NC16_RS05940	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NC16_RS05945	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
NC16_RS05950	COG0321	lipoyl(octanoyl) transferase activity
NC16_RS05955	COG2921	Belongs to the UPF0250 family
NC16_RS05960	COG1686	Belongs to the peptidase S11 family
NC16_RS05965	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
NC16_RS05970	COG0772	Belongs to the SEDS family
NC16_RS05975	COG0768	penicillin binding
NC16_RS05980	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
NC16_RS05985	COG0799	negative regulation of ribosome biogenesis
NC16_RS05990	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
NC16_RS05995	COG1466	dna polymerase III delta subunit
NC16_RS06000	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
NC16_RS06005	COG0495	leucyl-tRNA aminoacylation
NC16_RS06010	COG2888	peptidyl-tyrosine sulfation
NC16_RS06015	COG3547	Transposase (IS116 IS110 IS902 family)
NC16_RS06020	COG1126	abc transporter atp-binding protein
NC16_RS06025	COG0765	amino acid transport
NC16_RS06030	COG0765	amino acid transport
NC16_RS06040	COG0815	Transfers the fatty acyl group on membrane lipoproteins
NC16_RS06050	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
NC16_RS06055	COG1702	phosphate starvation-inducible protein PhoH
NC16_RS06060	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NC16_RS06065	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NC16_RS06080	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NC16_RS06125	COG0367	asparagine synthase
NC16_RS06130	COG1940	carbohydrate kinase activity
NC16_RS06130	COG1846	Transcriptional regulator
NC16_RS06135	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
NC16_RS06140	COG0363	glucosamine-6-phosphate deaminase activity
NC16_RS06145	COG1263	PTS System
NC16_RS06145	COG2190	(PTS) system
NC16_RS06145	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NC16_RS06150	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NC16_RS06155	COG0735	belongs to the Fur family
NC16_RS06160	COG0716	FMN binding
NC16_RS06170	COG0840	transmembrane signaling receptor activity
NC16_RS06180	COG0596	Alpha beta hydrolase
NC16_RS06185	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
NC16_RS06190	COG0033	Phosphoglucomutase
NC16_RS06200	COG0745	RESPONSE REGULATOR receiver
NC16_RS06205	COG2205	protein histidine kinase activity
NC16_RS06210	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
NC16_RS06215	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
NC16_RS06220	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
NC16_RS06240	COG1840	ABC-type Fe3 transport system, periplasmic component
NC16_RS06245	COG3842	ATPase activity
NC16_RS06250	COG3272	Protein of unknown function (DUF1722)
NC16_RS06255	COG0415	Belongs to the DNA photolyase family
NC16_RS06260	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
NC16_RS06265	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
NC16_RS06270	COG1984	allophanate hydrolase subunit 2
NC16_RS06275	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
NC16_RS06280	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
NC16_RS06285	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NC16_RS06310	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
NC16_RS06315	COG1053	succinate dehydrogenase
NC16_RS06320	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
NC16_RS06325	COG0567	Dehydrogenase, E1 component
NC16_RS06330	COG0508	dehydrogenase complex catalyzes the overall conversion of
NC16_RS06335	COG0045	succinate-CoA ligase (ADP-forming) activity
NC16_RS06340	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
NC16_RS06350	COG1271	oxidase subunit
NC16_RS06355	COG1294	oxidase, subunit
NC16_RS06360	COG4890	Cyd operon protein YbgT
NC16_RS06365	COG3790	cyd operon protein YbgE
NC16_RS06370	COG0824	Thioesterase
NC16_RS06375	COG0811	peptide transport
NC16_RS06380	COG0848	biopolymer transport protein
NC16_RS06385	COG3064	Membrane
NC16_RS06390	COG0823	Involved in the tonB-independent uptake of proteins
NC16_RS06395	COG2885	chlorophyll binding
NC16_RS06400	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
NC16_RS06420	COG1811	Na channel or pump
NC16_RS06430	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
NC16_RS06440	COG1230	cation diffusion facilitator family transporter
NC16_RS06445	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
NC16_RS06450	COG3385	transposase activity
NC16_RS06455	COG0588	phosphoglycerate mutase activity
NC16_RS06460	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NC16_RS06465	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NC16_RS06485	COG2017	converts alpha-aldose to the beta-anomer
NC16_RS06490	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NC16_RS06495	COG1119	ATPase activity
NC16_RS06500	COG2005	Transcriptional regulator
NC16_RS06500	COG3585	molybdate ion transport
NC16_RS06510	COG0725	ABC transporter, periplasmic molybdate-binding protein
NC16_RS06515	COG4149	molybdate abc transporter
NC16_RS06520	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
NC16_RS06535	COG0673	inositol 2-dehydrogenase activity
NC16_RS06545	COG2211	Major facilitator Superfamily
NC16_RS06550	COG0837	glucose binding
NC16_RS06555	COG0561	phosphatase activity
NC16_RS06565	COG2706	6-phosphogluconolactonase activity
NC16_RS06570	COG2963	transposase activity
NC16_RS06575	COG2801	Transposase and inactivated derivatives
NC16_RS06590	COG2864	formate dehydrogenase
NC16_RS06595	COG0437	4 iron, 4 sulfur cluster binding
NC16_RS06600	COG0243	molybdopterin cofactor binding
NC16_RS06600	COG3383	formate dehydrogenase (NAD+) activity
NC16_RS06605	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NC16_RS06605	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NC16_RS06610	COG0489	protein tyrosine kinase activity
NC16_RS06615	COG0572	uridine kinase
NC16_RS06620	COG0717	Belongs to the dCTP deaminase family
NC16_RS06625	COG2982	Protein involved in outer membrane biogenesis
NC16_RS06630	COG3069	C4-dicarboxylate transmembrane transporter activity
NC16_RS06635	COG1253	flavin adenine dinucleotide binding
NC16_RS06640	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NC16_RS06665	COG0438	transferase activity, transferring glycosyl groups
NC16_RS06700	COG2244	polysaccharide biosynthetic process
NC16_RS06725	COG1210	Utp--glucose-1-phosphate uridylyltransferase
NC16_RS06750	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NC16_RS06755	COG1605	Chorismate mutase
NC16_RS06765	COG2723	6-phospho-beta-galactosidase activity
NC16_RS06770	COG3711	transcriptional antiterminator
NC16_RS06775	COG3706	GGDEF domain
NC16_RS06790	COG1566	PFAM secretion protein HlyD family protein
NC16_RS06800	COG1566	PFAM secretion protein HlyD family protein
NC16_RS06835	COG3962	Belongs to the TPP enzyme family
NC16_RS06840	COG0673	inositol 2-dehydrogenase activity
NC16_RS06855	COG1172	Belongs to the binding-protein-dependent transport system permease family
NC16_RS06865	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NC16_RS06875	COG3718	enzyme involved in inositol metabolism
NC16_RS06890	COG3842	ATPase activity
NC16_RS06895	COG4208	sulfate ABC transporter
NC16_RS06900	COG1840	ABC-type Fe3 transport system, periplasmic component
NC16_RS06910	COG2723	6-phospho-beta-galactosidase activity
NC16_RS06915	COG1263	PTS System
NC16_RS06915	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NC16_RS06915	COG2190	(PTS) system
NC16_RS06925	COG3615	Tellurite resistance protein tehB
NC16_RS06940	COG0583	DNA-binding transcription factor activity
NC16_RS06950	COG0583	DNA-binding transcription factor activity
NC16_RS06955	COG2910	NAD(P)H-binding
NC16_RS06965	COG0653	protein targeting
NC16_RS06980	COG0738	Major facilitator superfamily
NC16_RS06985	COG3226	Transcriptional regulator
NC16_RS06995	COG2723	6-phospho-beta-galactosidase activity
NC16_RS07000	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
NC16_RS07000	COG0517	IMP dehydrogenase activity
NC16_RS07005	COG4227	nucleotidyltransferase activity
NC16_RS07020	COG0582	viral genome integration into host DNA
NC16_RS07050	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
NC16_RS07060	COG3504	Conjugal transfer protein
NC16_RS07065	COG3736	Type IV secretory pathway, component VirB8
NC16_RS07115	COG1733	regulation of RNA biosynthetic process
NC16_RS07125	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
NC16_RS07155	COG0582	viral genome integration into host DNA
NC16_RS07165	COG2223	nitrite transmembrane transporter activity
NC16_RS07175	COG3250	beta-galactosidase activity
NC16_RS07180	COG1609	Transcriptional regulator
NC16_RS07185	COG3842	ATPase activity
NC16_RS07195	COG1840	ABC-type Fe3 transport system, periplasmic component
NC16_RS07200	COG2271	Major facilitator Superfamily
NC16_RS07215	COG1464	Belongs to the NlpA lipoprotein family
NC16_RS07230	COG0583	DNA-binding transcription factor activity
NC16_RS07235	COG1301	dicarboxylic acid transport
NC16_RS07245	COG2851	Citrate transporter
NC16_RS07250	COG3383	formate dehydrogenase (NAD+) activity
NC16_RS07260	COG0672	)-iron permease
NC16_RS07275	COG0577	efflux transmembrane transporter activity
NC16_RS07275	COG1136	(ABC) transporter
NC16_RS07285	COG1136	(ABC) transporter
NC16_RS07285	COG0577	efflux transmembrane transporter activity
NC16_RS07290	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NC16_RS07295	COG0697	spore germination
NC16_RS07310	COG1301	dicarboxylic acid transport
NC16_RS07315	COG0371	Dehydrogenase
NC16_RS07320	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
NC16_RS07360	COG1012	belongs to the aldehyde dehydrogenase family
NC16_RS07365	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NC16_RS07385	COG0477	Major facilitator Superfamily
NC16_RS07395	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
NC16_RS07400	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NC16_RS07405	COG0747	negative chemotaxis
NC16_RS07420	COG0444	Belongs to the ABC transporter superfamily
NC16_RS07425	COG5464	transposase or invertase
NC16_RS07440	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NC16_RS07460	COG4771	TonB-dependent receptor
NC16_RS07480	COG2375	cellular response to nickel ion
NC16_RS07480	COG1132	(ABC) transporter
NC16_RS07485	COG1132	(ABC) transporter
NC16_RS07500	COG3009	Protein conserved in bacteria
NC16_RS07505	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
NC16_RS07505	COG3008	intermembrane lipid transfer
NC16_RS07510	COG2995	paraquat-inducible protein a
NC16_RS07525	COG0784	Response regulator, receiver
NC16_RS07525	COG0835	chemotaxis
NC16_RS07530	COG0625	glutathione transferase activity
NC16_RS07535	COG2910	NAD(P)H-binding
NC16_RS07540	COG1733	regulation of RNA biosynthetic process
NC16_RS07555	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NC16_RS07560	COG0640	Transcriptional regulator
NC16_RS07565	COG2814	Major facilitator Superfamily
NC16_RS07570	COG0789	Transcriptional regulator
NC16_RS07570	COG4978	Transcriptional regulator
NC16_RS07575	COG2723	6-phospho-beta-galactosidase activity
NC16_RS07590	COG3122	Protein conserved in bacteria
NC16_RS07620	COG0789	Transcriptional regulator
NC16_RS07630	COG0300	oxidoreductase activity
NC16_RS07645	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
NC16_RS07650	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
NC16_RS07670	COG3272	Protein of unknown function (DUF1722)
NC16_RS07680	COG0582	viral genome integration into host DNA
NC16_RS07785	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NC16_RS07825	COG0456	acetyltransferase
NC16_RS07860	COG0582	viral genome integration into host DNA
NC16_RS07890	COG4227	nucleotidyltransferase activity
NC16_RS07905	COG0232	Belongs to the dGTPase family. Type 2 subfamily
NC16_RS07950	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
NC16_RS07965	COG3736	Type IV secretory pathway, component VirB8
NC16_RS08015	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
NC16_RS08035	COG3423	Transcriptional regulator
NC16_RS08050	COG0582	viral genome integration into host DNA
NC16_RS08060	COG3228	Belongs to the MtfA family
NC16_RS08080	COG0401	homolog of Blt101
NC16_RS08100	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
NC16_RS08105	COG0303	'Molybdopterin
NC16_RS08110	COG4172	Belongs to the ABC transporter superfamily
NC16_RS08115	COG0747	negative chemotaxis
NC16_RS08120	COG0601	transmembrane transport
NC16_RS08125	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NC16_RS08130	COG0281	malic enzyme
NC16_RS08135	COG0295	cytidine deaminase activity
NC16_RS08145	COG1346	cytolysis
NC16_RS08150	COG1380	Effector of murein hydrolase LrgA
NC16_RS08155	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NC16_RS08160	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
NC16_RS08165	COG0156	8-amino-7-oxononanoate synthase activity
NC16_RS08170	COG2226	methyltransferase
NC16_RS08175	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
NC16_RS08195	COG0556	nucleotide-excision repair
NC16_RS08210	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
NC16_RS08215	COG0521	Mo-molybdopterin cofactor biosynthetic process
NC16_RS08220	COG0315	cyclic pyranopterin monophosphate synthase activity
NC16_RS08225	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
NC16_RS08230	COG0314	molybdopterin synthase activity
NC16_RS08235	COG0670	Belongs to the BI1 family
NC16_RS08240	COG0842	Transport permease protein
NC16_RS08245	COG0842	Transport permease protein
NC16_RS08250	COG1131	(ABC) transporter
NC16_RS08265	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NC16_RS08270	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NC16_RS08275	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NC16_RS08280	COG1120	ATPase activity
NC16_RS08290	COG0513	Belongs to the DEAD box helicase family
NC16_RS08300	COG2207	Transcriptional regulator
NC16_RS08300	COG3708	Transcriptional regulator
NC16_RS08305	COG2195	Cleaves the N-terminal amino acid of tripeptides
NC16_RS08310	COG0747	negative chemotaxis
NC16_RS08315	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
NC16_RS08320	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NC16_RS08325	COG0833	amino acid
NC16_RS08330	COG2040	homocysteine
NC16_RS08355	COG1686	Belongs to the peptidase S11 family
NC16_RS08370	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
NC16_RS08505	COG5301	cellulose 1,4-beta-cellobiosidase activity
NC16_RS08525	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NC16_RS08530	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NC16_RS08540	COG1126	abc transporter atp-binding protein
NC16_RS08545	COG0765	amino acid transport
NC16_RS08550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NC16_RS08555	COG0783	Belongs to the Dps family
NC16_RS08560	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
NC16_RS08560	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
NC16_RS08570	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
NC16_RS08575	COG2807	transmembrane transport
NC16_RS08580	COG0534	Mate efflux family protein
NC16_RS08585	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NC16_RS08595	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
NC16_RS08620	COG3083	sulfuric ester hydrolase activity
NC16_RS08625	COG3082	Protein of unknown function (DUF1414)
NC16_RS08630	COG3081	Nucleoid-associated protein
NC16_RS08640	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
NC16_RS08645	COG1061	Type III restriction enzyme res subunit
NC16_RS08660	COG2814	Major facilitator Superfamily
NC16_RS08670	COG4172	Belongs to the ABC transporter superfamily
NC16_RS08675	COG4239	(ABC) transporter, permease
NC16_RS08680	COG4174	ABC transporter (Permease)
NC16_RS08685	COG4166	transmembrane transport
NC16_RS08690	COG0791	NLP P60 protein
NC16_RS08695	COG0671	phosphoesterase, PA-phosphatase related
NC16_RS08700	COG0523	cobalamin synthesis protein
NC16_RS08705	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
NC16_RS08720	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
NC16_RS08720	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NC16_RS08725	COG1105	Belongs to the carbohydrate kinase PfkB family
NC16_RS08730	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NC16_RS08730	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
NC16_RS08730	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NC16_RS08735	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
NC16_RS08740	COG2855	membrane
NC16_RS08745	COG0583	DNA-binding transcription factor activity
NC16_RS08750	COG0833	amino acid
NC16_RS08755	COG4771	TonB-dependent receptor
NC16_RS08760	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NC16_RS08765	COG1172	Belongs to the binding-protein-dependent transport system permease family
NC16_RS08770	COG1129	ABC transporter
NC16_RS08775	COG0371	Dehydrogenase
NC16_RS08800	COG0583	DNA-binding transcription factor activity
NC16_RS08805	COG0840	transmembrane signaling receptor activity
NC16_RS08810	COG0302	gtp cyclohydrolase
NC16_RS08815	COG2311	Membrane
NC16_RS08820	COG2949	membrane
NC16_RS08825	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NC16_RS08830	COG2133	pyrroloquinoline quinone binding
NC16_RS08835	COG0625	glutathione transferase activity
NC16_RS08845	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
NC16_RS08850	COG2011	ABC-type metal ion transport system permease component
NC16_RS08855	COG1686	Belongs to the peptidase S11 family
NC16_RS08860	COG1349	DNA-binding transcription factor activity
NC16_RS08865	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
NC16_RS08870	COG2985	domain, Protein
NC16_RS08870	COG0569	domain protein
NC16_RS08885	COG0778	Nitroreductase
NC16_RS08890	COG0189	ligase activity
NC16_RS08900	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
NC16_RS08905	COG3842	ATPase activity
NC16_RS08910	COG1176	ABC-type spermidine putrescine transport system, permease component I
NC16_RS08915	COG1177	transmembrane transport
NC16_RS08925	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NC16_RS08930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NC16_RS08935	COG4160	amino acid transport
NC16_RS08940	COG4215	(ABC) transporter
NC16_RS08945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NC16_RS08950	COG1126	abc transporter atp-binding protein
NC16_RS08955	COG0393	Putative heavy-metal-binding
NC16_RS08960	COG3023	N-Acetylmuramoyl-L-alanine amidase
NC16_RS08965	COG0702	epimerase
NC16_RS08970	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NC16_RS08975	COG1151	hydroxylamine reductase activity
NC16_RS08980	COG2431	L-lysine efflux transmembrane transporter activity
NC16_RS08985	COG3593	DNA synthesis involved in DNA repair
NC16_RS08990	COG1278	Cold shock
NC16_RS09000	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
NC16_RS09005	COG0542	response to heat
NC16_RS09010	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NC16_RS09020	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
NC16_RS09025	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
NC16_RS09030	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
NC16_RS09035	COG4988	ABC transporter
NC16_RS09040	COG0492	ferredoxin-NADP+ reductase activity
NC16_RS09050	COG3107	peptidoglycan biosynthetic process
NC16_RS09050	COG1674	ftsk spoiiie
NC16_RS09055	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
NC16_RS09060	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
NC16_RS09065	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
NC16_RS09070	COG2814	Major facilitator Superfamily
NC16_RS09095	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
NC16_RS09100	COG1882	Formate acetyltransferase
NC16_RS09105	COG2116	formate transmembrane transporter activity
NC16_RS09110	COG1944	ATP diphosphatase activity
NC16_RS09115	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
NC16_RS09120	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
NC16_RS09125	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
NC16_RS09130	COG0539	negative regulation of cytoplasmic translation
NC16_RS09135	COG0776	regulation of translation
NC16_RS09140	COG0140	phosphoribosyl-ATP diphosphatase activity
NC16_RS09140	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
NC16_RS09145	COG0107	imidazoleglycerol-phosphate synthase activity
NC16_RS09150	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
NC16_RS09155	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
NC16_RS09160	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
NC16_RS09160	COG0131	Imidazoleglycerol-phosphate dehydratase
NC16_RS09165	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NC16_RS09170	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
NC16_RS09175	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
NC16_RS09180	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NC16_RS09185	COG0840	transmembrane signaling receptor activity
NC16_RS09190	COG0840	transmembrane signaling receptor activity
NC16_RS09195	COG4565	transcriptional regulatory protein
NC16_RS09205	COG3493	citrate carrier protein
NC16_RS09210	COG0179	Fumarylacetoacetate (FAA) hydrolase
NC16_RS09215	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
NC16_RS09220	COG3052	prosthetic group binding
NC16_RS09240	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
NC16_RS09245	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
NC16_RS09255	COG0531	amino acid
NC16_RS09260	COG2925	Exonuclease
NC16_RS09265	COG4607	ABC-type enterochelin transport system periplasmic component
NC16_RS09275	COG4605	iron ion homeostasis
NC16_RS09280	COG4604	ABC transporter, ATP-binding protein
NC16_RS09290	COG2926	Belongs to the UPF0265 family
NC16_RS09295	COG2333	competence protein COMEC
NC16_RS09295	COG0658	competence protein
NC16_RS09300	COG1132	(ABC) transporter
NC16_RS09305	COG1663	tetraacyldisaccharide 4'-kinase activity
NC16_RS09310	COG2835	tetraacyldisaccharide 4'-kinase activity
NC16_RS09315	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
NC16_RS09325	COG3173	Aminoglycoside phosphotransferase
NC16_RS09330	COG1434	Gram-negative-bacterium-type cell wall biogenesis
NC16_RS09335	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NC16_RS09340	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
NC16_RS09345	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
NC16_RS09350	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
NC16_RS09355	COG2989	Protein conserved in bacteria
NC16_RS09360	COG3108	Peptidase M15
NC16_RS09365	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NC16_RS09370	COG1448	Aminotransferase
NC16_RS09380	COG0017	Asparaginyl-tRNA synthetase
NC16_RS09390	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
NC16_RS09395	COG0308	aminopeptidase N
NC16_RS09400	COG0167	dihydroorotate dehydrogenase activity
NC16_RS09410	COG3217	Mosc domain protein beta barrel domain protein
NC16_RS09410	COG0633	Ferredoxin
NC16_RS09415	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
NC16_RS09415	COG0116	Belongs to the methyltransferase superfamily
NC16_RS09420	COG0488	(ABC) transporter
NC16_RS09425	COG2995	paraquat-inducible protein a
NC16_RS09430	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
NC16_RS09430	COG3008	intermembrane lipid transfer
NC16_RS09435	COG3009	Protein conserved in bacteria
NC16_RS09445	COG3130	regulation of translation
NC16_RS09450	COG0840	transmembrane signaling receptor activity
NC16_RS09485	COG0546	phosphoglycolate phosphatase activity
NC16_RS09500	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
NC16_RS09505	COG3381	protein complex oligomerization
NC16_RS09515	COG2999	glutathione oxidoreductase activity
NC16_RS09520	COG0477	Major facilitator Superfamily
NC16_RS09525	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NC16_RS09530	COG3132	Protein of unknown function, DUF480
NC16_RS09540	COG0728	peptidoglycan biosynthetic process
NC16_RS09545	COG0018	arginyl-trna synthetase
NC16_RS09550	COG3102	Protein conserved in bacteria
NC16_RS09555	COG3142	Participates in the control of copper homeostasis
NC16_RS09560	COG0500	methyltransferase
NC16_RS09565	COG2226	methyltransferase
NC16_RS09575	COG3788	relative of glutathione S-transferase, MAPEG superfamily
NC16_RS09580	COG1801	Protein of unknown function DUF72
NC16_RS09585	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
NC16_RS09590	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
NC16_RS09595	COG0494	nUDIX hydrolase
NC16_RS09600	COG0217	transcriptional regulatory protein
NC16_RS09610	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
NC16_RS09615	COG0632	four-way junction helicase activity
NC16_RS09620	COG2255	four-way junction helicase activity
NC16_RS09625	COG4580	involved in the transport of maltose and maltodextrins
NC16_RS09630	COG1447	Phosphotransferase system cellobiose-specific component IIA
NC16_RS09635	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NC16_RS09640	COG1609	Transcriptional regulator
NC16_RS09645	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NC16_RS09650	COG1121	(ABC) transporter
NC16_RS09655	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
NC16_RS09660	COG0739	heme binding
NC16_RS09665	COG1560	Kdo2-lipid A biosynthetic process
NC16_RS09670	COG0469	pyruvate kinase activity
NC16_RS09675	COG1737	Transcriptional regulator
NC16_RS09680	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
NC16_RS09685	COG0800	Aldolase
NC16_RS09690	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
NC16_RS09695	COG1770	oligopeptidase
NC16_RS09705	COG1528	Iron-storage protein
NC16_RS09715	COG1278	Cold shock
NC16_RS09730	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
NC16_RS09745	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
NC16_RS09745	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
NC16_RS09750	COG3008	intermembrane lipid transfer
NC16_RS09755	COG2995	paraquat-inducible protein a
NC16_RS09760	COG1956	GAF domain-containing protein
NC16_RS09765	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
NC16_RS09775	COG2207	Transcriptional regulator
NC16_RS09790	COG1177	transmembrane transport
NC16_RS09800	COG3842	ATPase activity
NC16_RS09805	COG2195	Cleaves the N-terminal amino acid of tripeptides
NC16_RS09810	COG2850	peptidyl-arginine hydroxylation
NC16_RS09830	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
NC16_RS09835	COG2915	High frequency lysogenization protein hflD homolog
NC16_RS09840	COG0482	sulfurtransferase activity
NC16_RS09850	COG1187	pseudouridine synthase activity
NC16_RS09855	COG0538	isocitrate dehydrogenase activity
NC16_RS09860	COG0348	domain, Protein
NC16_RS09885	COG3275	phosphorelay sensor kinase activity
NC16_RS09890	COG3279	Response regulator of the LytR AlgR family
NC16_RS09895	COG2223	nitrite transmembrane transporter activity
NC16_RS09900	COG1653	transport
NC16_RS09910	COG0501	Belongs to the peptidase M48B family
NC16_RS09915	COG0823	Involved in the tonB-independent uptake of proteins
NC16_RS09930	COG1113	amino acid transport
NC16_RS09935	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NC16_RS09940	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
NC16_RS09945	COG0291	Belongs to the bacterial ribosomal protein bL35 family
NC16_RS09950	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
NC16_RS09955	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
NC16_RS09960	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NC16_RS09960	COG0072	phenylalanine-tRNA ligase activity
NC16_RS09965	COG0776	regulation of translation
NC16_RS09975	COG1132	(ABC) transporter
NC16_RS09985	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
NC16_RS09990	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NC16_RS09995	COG1823	symporter activity
NC16_RS10000	COG1988	membrane-bound metal-dependent
NC16_RS10005	COG2755	lipolytic protein G-D-S-L family
NC16_RS10005	COG0657	acetylesterase activity
NC16_RS10010	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
NC16_RS10020	COG3842	ATPase activity
NC16_RS10025	COG0395	ABC-type sugar transport system, permease component
NC16_RS10030	COG1175	transmembrane transport
NC16_RS10040	COG1028	Short-chain dehydrogenase reductase Sdr
NC16_RS10045	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
NC16_RS10050	COG1917	Cupin 2, conserved barrel domain protein
NC16_RS10055	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NC16_RS10065	COG3001	Fructosamine kinase
NC16_RS10070	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NC16_RS10075	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NC16_RS10080	COG1121	(ABC) transporter
NC16_RS10085	COG0803	Belongs to the bacterial solute-binding protein 9 family
NC16_RS10095	COG2226	methyltransferase
NC16_RS10100	COG1971	Probably functions as a manganese efflux pump
NC16_RS10105	COG4811	Protein of unknown function (DUF986)
NC16_RS10110	COG3716	PTS system mannose fructose sorbose family IID component
NC16_RS10115	COG3715	PTS system
NC16_RS10120	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NC16_RS10120	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
NC16_RS10125	COG1253	flavin adenine dinucleotide binding
NC16_RS10140	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
NC16_RS10150	COG1760	l-serine dehydratase
NC16_RS10155	COG0494	nUDIX hydrolase
NC16_RS10165	COG3140	Belongs to the UPF0181 family
NC16_RS10170	COG0251	oxidation-reduction process
NC16_RS10175	COG1199	ATP-dependent helicase activity
NC16_RS10185	COG3065	identical protein binding
NC16_RS10195	COG0318	PFAM AMP-dependent synthetase and ligase
NC16_RS10200	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
NC16_RS10205	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
NC16_RS10210	COG2894	cell division
NC16_RS10215	COG0850	regulation of cytokinetic process
NC16_RS10220	COG3100	YcgL domain-containing protein
NC16_RS10230	COG0179	Fumarylacetoacetate (FAA) hydrolase
NC16_RS10235	COG2983	Belongs to the UPF0260 family
NC16_RS10245	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
NC16_RS10250	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
NC16_RS10255	COG2186	Transcriptional regulator
NC16_RS10260	COG2719	SpoVR family
NC16_RS10265	COG3684	Belongs to the aldolase LacD family
NC16_RS10275	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NC16_RS10295	COG0205	6-phosphofructokinase activity
NC16_RS10300	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NC16_RS10315	COG2718	Belongs to the UPF0229 family
NC16_RS10320	COG2766	serine protein kinase
NC16_RS10325	COG3713	MltA-interacting MipA family protein
NC16_RS10330	COG0656	L-ascorbic acid biosynthetic process
NC16_RS10345	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NC16_RS10350	COG3139	Protein of unknown function (DUF1315)
NC16_RS10355	COG1335	isochorismatase
NC16_RS10360	COG0252	asparaginase activity
NC16_RS10365	COG0616	signal peptide processing
NC16_RS10370	COG0778	Nitroreductase
NC16_RS10375	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NC16_RS10385	COG0708	Exodeoxyribonuclease III
NC16_RS10390	COG2860	membrane
NC16_RS10410	COG0788	formyltetrahydrofolate deformylase activity
NC16_RS10415	COG3012	SEC-C Motif Domain Protein
NC16_RS10420	COG1752	Esterase of the alpha-beta hydrolase superfamily
NC16_RS10425	COG0745	RESPONSE REGULATOR receiver
NC16_RS10430	COG1210	Utp--glucose-1-phosphate uridylyltransferase
NC16_RS10440	COG1435	thymidine kinase activity
NC16_RS10445	COG1454	alcohol dehydrogenase
NC16_RS10445	COG1012	belongs to the aldehyde dehydrogenase family
NC16_RS10460	COG0601	transmembrane transport
NC16_RS10465	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NC16_RS10470	COG0444	Belongs to the ABC transporter superfamily
NC16_RS10480	COG3099	Belongs to the UPF0263 family
NC16_RS10485	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NC16_RS10495	COG2350	Protein conserved in bacteria
NC16_RS10505	COG1607	acyl-coa hydrolase
NC16_RS10510	COG2917	probably involved in intracellular septation
NC16_RS10520	COG3047	cAMP biosynthetic process
NC16_RS10525	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
NC16_RS10530	COG0159	tryptophan synthase activity
NC16_RS10535	COG0133	tryptophan synthase activity
NC16_RS10540	COG0135	phosphoribosylanthranilate isomerase activity
NC16_RS10540	COG0134	indole-3-glycerol-phosphate synthase activity
NC16_RS10545	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NC16_RS10550	COG0512	Glutamine amidotransferase of anthranilate synthase
NC16_RS10560	COG0613	PHP domain protein
NC16_RS10565	COG0009	L-threonylcarbamoyladenylate synthase
NC16_RS10570	COG1187	pseudouridine synthase activity
NC16_RS10575	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
NC16_RS10580	COG1028	Short-chain dehydrogenase reductase Sdr
NC16_RS10585	COG0616	signal peptide processing
NC16_RS10605	COG3104	oligopeptide transport
NC16_RS10610	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
NC16_RS10620	COG4659	FMN binding
NC16_RS10625	COG4658	electron transport chain
NC16_RS10630	COG4656	Part of a membrane complex involved in electron transport
NC16_RS10635	COG2878	Part of a membrane complex involved in electron transport
NC16_RS10640	COG4657	Part of a membrane complex involved in electron transport
NC16_RS10650	COG2160	L-arabinose isomerase activity
NC16_RS10655	COG1069	ribulokinase activity
NC16_RS10660	COG1879	ABC-type sugar transport system periplasmic component
NC16_RS10665	COG1129	ABC transporter
NC16_RS10670	COG1172	Belongs to the binding-protein-dependent transport system permease family
NC16_RS10680	COG0673	inositol 2-dehydrogenase activity
NC16_RS10685	COG0385	Bile acid
NC16_RS10695	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
NC16_RS10705	COG5339	Protein conserved in bacteria
NC16_RS10710	COG1482	cell wall glycoprotein biosynthetic process
NC16_RS10715	COG0114	fumarate hydratase activity
NC16_RS10725	COG2814	Major facilitator Superfamily
NC16_RS10730	COG0583	DNA-binding transcription factor activity
NC16_RS10740	COG1940	carbohydrate kinase activity
NC16_RS10745	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
NC16_RS10750	COG0477	Major facilitator Superfamily
NC16_RS10770	COG4221	oxidoreductase activity
NC16_RS10775	COG1215	transferase activity, transferring glycosyl groups
NC16_RS10790	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
NC16_RS10805	COG1942	4-Oxalocrotonate Tautomerase
NC16_RS10810	COG0697	spore germination
NC16_RS10815	COG0076	glutamate decarboxylase activity
NC16_RS10820	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
NC16_RS10835	COG1649	PFAM Uncharacterised BCR, COG1649
NC16_RS10840	COG4628	conserved protein (DUF2132)
NC16_RS10880	COG0456	acetyltransferase
NC16_RS10885	COG0738	Major facilitator superfamily
NC16_RS10895	COG3783	Cytochrome b(562)
NC16_RS10900	COG1764	response to oxidative stress
NC16_RS10905	COG4305	rare lipoprotein A
NC16_RS10935	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
NC16_RS10950	COG0673	inositol 2-dehydrogenase activity
NC16_RS10955	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
NC16_RS10960	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NC16_RS10970	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
NC16_RS10975	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
NC16_RS10985	COG2877	3-deoxy-8-phosphooctulonate synthase activity
NC16_RS10990	COG2912	Transglutaminase-like superfamily
NC16_RS11000	COG2890	protein-(glutamine-N5) methyltransferase activity
NC16_RS11005	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
NC16_RS11010	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
NC16_RS11015	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
NC16_RS11020	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
NC16_RS11025	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NC16_RS11035	COG0193	aminoacyl-tRNA hydrolase activity
NC16_RS11040	COG0012	GTP binding
NC16_RS11070	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
NC16_RS11075	COG0583	DNA-binding transcription factor activity
NC16_RS11080	COG2271	Major facilitator Superfamily
NC16_RS11085	COG1028	Short-chain dehydrogenase reductase Sdr
NC16_RS11090	COG3959	Transketolase, thiamine diphosphate binding domain
NC16_RS11095	COG3958	Transketolase
NC16_RS11135	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NC16_RS11150	COG2755	lipolytic protein G-D-S-L family
NC16_RS11185	COG0523	cobalamin synthesis protein
NC16_RS11190	COG3443	Belongs to the bacterial solute-binding protein 9 family
NC16_RS11195	COG0346	lactoylglutathione lyase activity
NC16_RS11200	COG0483	inositol monophosphate 1-phosphatase activity
NC16_RS11205	COG2723	6-phospho-beta-galactosidase activity
NC16_RS11210	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NC16_RS11210	COG1263	PTS System
NC16_RS11220	COG1609	Transcriptional regulator
NC16_RS11225	COG2826	transposase and inactivated derivatives, IS30 family
NC16_RS11250	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NC16_RS11255	COG1473	amidohydrolase
NC16_RS11265	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NC16_RS11275	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
NC16_RS11285	COG0765	amino acid transport
NC16_RS11290	COG1126	abc transporter atp-binding protein
NC16_RS11300	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
NC16_RS11305	COG0640	Transcriptional regulator
NC16_RS11315	COG1129	ABC transporter
NC16_RS11335	COG1802	Transcriptional regulator
NC16_RS11430	COG3210	domain, Protein
NC16_RS11435	COG3210	domain, Protein
NC16_RS11455	COG3210	domain, Protein
NC16_RS11465	COG3210	domain, Protein
NC16_RS11520	COG2831	hemolysin activation secretion protein
NC16_RS11525	COG1802	Transcriptional regulator
NC16_RS11590	COG3501	Rhs element vgr protein
NC16_RS11635	COG4669	(LipO)protein
NC16_RS11650	COG2200	EAL domain
NC16_RS11660	COG2197	response regulator
NC16_RS11665	COG3850	Histidine kinase
NC16_RS11690	COG1157	protein secretion by the type III secretion system
NC16_RS11715	COG4794	Type iii secretion
NC16_RS11725	COG4792	protein secretion
NC16_RS11730	COG0583	DNA-binding transcription factor activity
NC16_RS11745	COG1464	Belongs to the NlpA lipoprotein family
NC16_RS11750	COG4948	Mandelate Racemase Muconate Lactonizing
NC16_RS11755	COG2011	ABC-type metal ion transport system permease component
NC16_RS11760	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
NC16_RS11765	COG0671	phosphoesterase, PA-phosphatase related
NC16_RS11775	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
NC16_RS11785	COG1028	Short-chain dehydrogenase reductase Sdr
NC16_RS11795	COG1176	ABC-type spermidine putrescine transport system, permease component I
NC16_RS11805	COG1012	belongs to the aldehyde dehydrogenase family
NC16_RS11810	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
NC16_RS11820	COG3842	ATPase activity
NC16_RS11825	COG1028	Short-chain dehydrogenase reductase Sdr
NC16_RS11840	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NC16_RS11855	COG2261	transglycosylase associated protein
NC16_RS11875	COG2423	ornithine cyclodeaminase activity
NC16_RS11890	COG1846	Transcriptional regulator
NC16_RS11895	COG0697	spore germination
NC16_RS11900	COG2181	nitrate reductase activity
NC16_RS11905	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
NC16_RS11910	COG1140	nitrate reductase beta subunit
NC16_RS11915	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
NC16_RS11920	COG2223	nitrite transmembrane transporter activity
NC16_RS11925	COG3850	Histidine kinase
NC16_RS11930	COG2197	response regulator
NC16_RS11945	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
NC16_RS11960	COG0387	Pfam Sodium calcium exchanger
NC16_RS11965	COG0659	secondary active sulfate transmembrane transporter activity
NC16_RS12005	COG0745	RESPONSE REGULATOR receiver
NC16_RS12010	COG2205	protein histidine kinase activity
NC16_RS12025	COG3591	Belongs to the peptidase S1B family
NC16_RS12030	COG5001	Diguanylate cyclase
NC16_RS12030	COG3300	MHYT domain
NC16_RS12040	COG1643	Atp-dependent helicase
NC16_RS12045	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
NC16_RS12055	COG2911	Protein conserved in bacteria
NC16_RS12060	COG0840	transmembrane signaling receptor activity
NC16_RS12065	COG0840	transmembrane signaling receptor activity
NC16_RS12070	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NC16_RS12095	COG0037	tRNA processing
NC16_RS12100	COG0598	Magnesium transport protein CorA
NC16_RS12105	COG4166	transmembrane transport
NC16_RS12110	COG2866	Carboxypeptidase
NC16_RS12115	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
NC16_RS12130	COG3768	UPF0283 membrane protein
NC16_RS12135	COG3106	COG3106 Predicted ATPase
NC16_RS12140	COG2831	hemolysin activation secretion protein
NC16_RS12150	COG3210	domain, Protein
NC16_RS12180	COG1983	PspC domain protein
NC16_RS12190	COG1842	Phage shock protein A
NC16_RS12195	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
NC16_RS12220	COG4166	transmembrane transport
NC16_RS12230	COG4171	peptide transport system, permease
NC16_RS12275	COG2271	Major facilitator Superfamily
NC16_RS12280	COG1609	Transcriptional regulator
NC16_RS12285	COG0583	DNA-binding transcription factor activity
NC16_RS12290	COG0243	molybdopterin cofactor binding
NC16_RS12295	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
NC16_RS12300	COG4989	oxidoreductase activity
NC16_RS12305	COG1966	Carbon starvation protein
NC16_RS12310	COG0235	Class ii aldolase
NC16_RS12320	COG0023	Translation Initiation Factor
NC16_RS12325	COG0284	orotidine-5'-phosphate decarboxylase activity
NC16_RS12330	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
NC16_RS12335	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
NC16_RS12345	COG1082	Xylose isomerase domain protein TIM barrel
NC16_RS12350	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
NC16_RS12355	COG3958	Transketolase
NC16_RS12360	COG3959	Transketolase, thiamine diphosphate binding domain
NC16_RS12365	COG1172	Belongs to the binding-protein-dependent transport system permease family
NC16_RS12370	COG1129	ABC transporter
NC16_RS12380	COG1879	ABC-type sugar transport system periplasmic component
NC16_RS12385	COG0671	phosphoesterase, PA-phosphatase related
NC16_RS12390	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NC16_RS12400	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
NC16_RS12410	COG1301	dicarboxylic acid transport
NC16_RS12415	COG0625	glutathione transferase activity
NC16_RS12420	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
NC16_RS12425	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
NC16_RS12430	COG0259	pyridoxamine-phosphate oxidase activity
NC16_RS12435	COG3895	Periplasmic Protein
NC16_RS12440	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
NC16_RS12455	COG3313	Fe-S protein
NC16_RS12460	COG0346	lactoylglutathione lyase activity
NC16_RS12465	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NC16_RS12470	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
NC16_RS12475	COG0791	NLP P60 protein
NC16_RS12480	COG1609	Transcriptional regulator
NC16_RS12485	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
NC16_RS12490	COG0307	riboflavin synthase, alpha
NC16_RS12495	COG0534	Mate efflux family protein
NC16_RS12520	COG3665	Urea carboxylase-associated protein
NC16_RS12525	COG1116	anion transmembrane transporter activity
NC16_RS12530	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NC16_RS12555	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
NC16_RS12560	COG1408	metallophosphoesterase
NC16_RS12570	COG0561	phosphatase activity
NC16_RS12575	COG2076	Multidrug Resistance protein
NC16_RS12585	COG0582	viral genome integration into host DNA
NC16_RS12590	COG0583	DNA-binding transcription factor activity
NC16_RS12630	COG0629	single-stranded DNA binding
NC16_RS12635	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NC16_RS12645	COG0270	DNA (cytosine-5-)-methyltransferase activity
NC16_RS12690	COG0210	DNA helicase
NC16_RS12745	COG0583	DNA-binding transcription factor activity
NC16_RS12850	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NC16_RS12865	COG1335	isochorismatase
NC16_RS12870	COG0640	Transcriptional regulator
NC16_RS12875	COG1230	cation diffusion facilitator family transporter
NC16_RS12885	COG1764	response to oxidative stress
NC16_RS12900	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
NC16_RS12970	COG3209	COG3209 Rhs family protein
NC16_RS12970	COG4104	PAAR repeat-containing protein
NC16_RS12980	COG3501	Rhs element vgr protein
NC16_RS12990	COG3423	Transcriptional regulator
NC16_RS13000	COG2197	response regulator
NC16_RS13005	COG3850	Histidine kinase
NC16_RS13010	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
NC16_RS13010	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
NC16_RS13015	COG3062	negative regulation of establishment of protein localization
NC16_RS13020	COG0243	molybdopterin cofactor binding
NC16_RS13025	COG0437	4 iron, 4 sulfur cluster binding
NC16_RS13030	COG0348	domain, Protein
NC16_RS13035	COG3043	anaerobic respiration
NC16_RS13040	COG3005	denitrification pathway
NC16_RS13045	COG4235	cytochrome complex assembly
NC16_RS13045	COG3088	subunit of a heme lyase
NC16_RS13050	COG4235	cytochrome complex assembly
NC16_RS13050	COG3088	subunit of a heme lyase
NC16_RS13055	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NC16_RS13060	COG1138	Cytochrome C-type biogenesis protein
NC16_RS13065	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
NC16_RS13070	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NC16_RS13075	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NC16_RS13080	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NC16_RS13085	COG4133	protoheme IX ABC transporter activity
NC16_RS13090	COG4235	cytochrome complex assembly
NC16_RS13095	COG3088	subunit of a heme lyase
NC16_RS13100	COG1138	Cytochrome C-type biogenesis protein
NC16_RS13105	COG3301	Polysulphide reductase, NrfD
NC16_RS13110	COG0437	4 iron, 4 sulfur cluster binding
NC16_RS13115	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
NC16_RS13120	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
NC16_RS13130	COG2382	esterase
NC16_RS13165	COG3385	transposase activity
NC16_RS13170	COG4238	major outer membrane lipoprotein
NC16_RS13175	COG1388	LysM domain
NC16_RS13175	COG1376	ErfK ybiS ycfS ynhG family protein
NC16_RS13180	COG2166	iron-sulfur cluster assembly
NC16_RS13185	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NC16_RS13190	COG0719	Fe-S assembly protein
NC16_RS13195	COG0396	ATPase activity
NC16_RS13200	COG0719	Fe-S assembly protein
NC16_RS13205	COG0316	Belongs to the HesB IscA family
NC16_RS13215	COG2050	protein possibly involved in aromatic compounds catabolism
NC16_RS13220	COG0247	lactate metabolic process
NC16_RS13220	COG0277	FAD linked oxidase domain protein
NC16_RS13225	COG0628	permease
NC16_RS13235	COG1477	protein flavinylation
NC16_RS13240	COG0574	Belongs to the PEP-utilizing enzyme family
NC16_RS13240	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NC16_RS13245	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
NC16_RS13250	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
NC16_RS13255	COG3720	iron ion transport
NC16_RS13260	COG4558	Periplasmic binding protein
NC16_RS13265	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NC16_RS13270	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
NC16_RS13275	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
NC16_RS13290	COG0095	Lipoate-protein ligase
NC16_RS13295	COG0791	NLP P60 protein
NC16_RS13300	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
NC16_RS13305	COG0386	Belongs to the glutathione peroxidase family
NC16_RS13310	COG4139	cobalamin transport
NC16_RS13315	COG2226	methyltransferase
NC16_RS13320	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NC16_RS13335	COG1940	carbohydrate kinase activity
NC16_RS13340	COG4591	ABC-type transport system involved in lipoprotein release permease component
NC16_RS13345	COG1136	(ABC) transporter
NC16_RS13350	COG4591	ABC-type transport system involved in lipoprotein release permease component
NC16_RS13355	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
NC16_RS13360	COG0443	Heat shock 70 kDa protein
NC16_RS13365	COG1309	transcriptional regulator
NC16_RS13375	COG2814	Major facilitator Superfamily
NC16_RS13380	COG3134	Outer membrane lipoprotein
NC16_RS13385	COG1252	NADH dehydrogenase
NC16_RS13390	COG3150	esterase
NC16_RS13395	COG1472	Belongs to the glycosyl hydrolase 3 family
NC16_RS13405	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
NC16_RS13415	COG0537	adenosine 5'-monophosphoramidase activity
NC16_RS13420	COG0477	Major facilitator Superfamily
NC16_RS13435	COG1263	PTS System
NC16_RS13435	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NC16_RS13440	COG0084	hydrolase, TatD family'
NC16_RS13445	COG0470	DNA polymerase III
NC16_RS13450	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
NC16_RS13455	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
NC16_RS13460	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NC16_RS13465	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NC16_RS13470	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NC16_RS13480	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
NC16_RS13485	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NC16_RS13490	COG0416	fatty acid biosynthetic process
NC16_RS13495	COG0333	Belongs to the bacterial ribosomal protein bL32 family
NC16_RS13500	COG1399	metal-binding, possibly nucleic acid-binding protein
NC16_RS13505	COG0424	maF-like protein
NC16_RS13510	COG0564	pseudouridine synthase activity
NC16_RS13515	COG1530	ribonuclease E activity
NC16_RS13515	COG1530	ribonuclease E activity
NC16_RS13520	COG3385	transposase activity
NC16_RS13530	COG0418	dihydroorotase activity
NC16_RS13550	COG3038	cytochrome b561
NC16_RS13555	COG2353	YceI-like domain
NC16_RS13560	COG1054	Belongs to the UPF0176 family
NC16_RS13565	COG1902	pentaerythritol trinitrate reductase activity
NC16_RS13570	COG1560	Kdo2-lipid A biosynthetic process
NC16_RS13575	COG2943	transferase activity, transferring hexosyl groups
NC16_RS13580	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
NC16_RS13600	COG0840	transmembrane signaling receptor activity
NC16_RS13620	COG0589	response to stress
NC16_RS13650	COG0670	Belongs to the BI1 family
NC16_RS13655	COG2920	part of a sulfur-relay system
NC16_RS13660	COG1254	Belongs to the acylphosphatase family
NC16_RS13665	COG3785	DNA binding
NC16_RS13670	COG1832	CoA-binding protein
NC16_RS13680	COG1803	Methylglyoxal synthase
NC16_RS13685	COG0210	DNA helicase
NC16_RS13690	COG3304	Inner membrane component domain
NC16_RS13695	COG1289	transmembrane transporter activity
NC16_RS13700	COG3070	regulator of competence-specific genes
NC16_RS13705	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
NC16_RS13725	COG1067	ATP-dependent peptidase activity
NC16_RS13730	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
NC16_RS13735	COG2979	Protein of unknown function (DUF533)
NC16_RS13740	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
NC16_RS13745	COG1012	belongs to the aldehyde dehydrogenase family
NC16_RS13750	COG1309	transcriptional regulator
NC16_RS13755	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NC16_RS13770	COG1702	phosphate starvation-inducible protein PhoH
NC16_RS13785	COG1191	sigma factor activity
NC16_RS13790	COG0463	Glycosyl transferase, family 2
NC16_RS13815	COG0438	transferase activity, transferring glycosyl groups
NC16_RS13815	COG1216	Glycosyl transferase, family 2
NC16_RS13820	COG1216	Glycosyl transferase, family 2
NC16_RS13820	COG0438	transferase activity, transferring glycosyl groups
NC16_RS13855	COG1677	Flagellar hook-basal body complex protein FliE
NC16_RS13870	COG1317	bacterial-type flagellum organization
NC16_RS13890	COG1580	Controls the rotational direction of flagella during chemotaxis
NC16_RS13940	COG1706	bacterial-type flagellum-dependent cell motility
NC16_RS13945	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
NC16_RS13955	COG4787	bacterial-type flagellum-dependent cell motility
NC16_RS13960	COG1749	Flagellar hook protein flgE
NC16_RS13965	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
NC16_RS13970	COG1558	bacterial-type flagellum-dependent cell motility
NC16_RS13975	COG1815	bacterial-type flagellum-dependent cell motility
NC16_RS13985	COG2747	anti-sigma28 factor FlgM
NC16_RS14000	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
NC16_RS14005	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
NC16_RS14015	COG0745	RESPONSE REGULATOR receiver
NC16_RS14020	COG2201	protein-glutamate methylesterase activity
NC16_RS14025	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
NC16_RS14030	COG0840	transmembrane signaling receptor activity
NC16_RS14035	COG0835	chemotaxis
NC16_RS14040	COG2198	Histidine kinase
NC16_RS14040	COG0643	Histidine kinase
NC16_RS14065	COG0697	spore germination
NC16_RS14070	COG0840	transmembrane signaling receptor activity
NC16_RS14085	COG3706	GGDEF domain
NC16_RS14100	COG0583	DNA-binding transcription factor activity
NC16_RS14130	COG2003	Belongs to the UPF0758 family
NC16_RS14145	COG3596	GTP binding
NC16_RS14170	COG3501	Rhs element vgr protein
NC16_RS14180	COG4104	PAAR repeat-containing protein
NC16_RS14180	COG3209	COG3209 Rhs family protein
NC16_RS14245	COG0582	viral genome integration into host DNA
NC16_RS14265	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NC16_RS14270	COG0322	excinuclease ABC activity
NC16_RS14275	COG2197	response regulator
NC16_RS14295	COG1113	amino acid transport
NC16_RS14315	COG2828	Protein conserved in bacteria
NC16_RS14330	COG2814	Major facilitator Superfamily
NC16_RS14335	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NC16_RS14355	COG2951	lytic endotransglycosylase activity
NC16_RS14360	COG3547	Transposase (IS116 IS110 IS902 family)
NC16_RS14370	COG0481	GTPase activity
NC16_RS14375	COG0659	secondary active sulfate transmembrane transporter activity
NC16_RS14380	COG4948	Mandelate Racemase Muconate Lactonizing
NC16_RS14400	COG0745	RESPONSE REGULATOR receiver
NC16_RS14405	COG5002	protein histidine kinase activity
NC16_RS14405	COG5000	phosphorelay sensor kinase activity
NC16_RS14420	COG0765	amino acid transport
NC16_RS14425	COG0765	amino acid transport
NC16_RS14480	COG0745	RESPONSE REGULATOR receiver
NC16_RS14515	COG1902	pentaerythritol trinitrate reductase activity
NC16_RS14520	COG0640	Transcriptional regulator
NC16_RS14525	COG1070	Carbohydrate kinase
NC16_RS14530	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NC16_RS14540	COG1172	Belongs to the binding-protein-dependent transport system permease family
NC16_RS14545	COG1172	Belongs to the binding-protein-dependent transport system permease family
NC16_RS14550	COG1129	ABC transporter
NC16_RS14560	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
NC16_RS14565	COG4807	Protein conserved in bacteria
NC16_RS14570	COG5464	transposase or invertase
NC16_RS14575	COG1648	precorrin-2 dehydrogenase activity
NC16_RS14575	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NC16_RS14580	COG0243	molybdopterin cofactor binding
NC16_RS14585	COG2146	nitrite reductase [NAD(P)H] activity
NC16_RS14585	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NC16_RS14590	COG1116	anion transmembrane transporter activity
NC16_RS14600	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NC16_RS14610	COG3707	response regulator
NC16_RS14625	COG1271	oxidase subunit
NC16_RS14630	COG1294	oxidase, subunit
NC16_RS14635	COG4890	Cyd operon protein YbgT
NC16_RS14640	COG2149	membrane
NC16_RS14650	COG3058	Necessary for formate dehydrogenase activity
NC16_RS14655	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NC16_RS14660	COG0519	Catalyzes the synthesis of GMP from XMP
NC16_RS14665	COG4993	Dehydrogenase
NC16_RS14690	COG4771	TonB-dependent receptor
NC16_RS14700	COG0488	(ABC) transporter
NC16_RS14715	COG1263	PTS System
NC16_RS14715	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NC16_RS14720	COG0366	Alpha amylase catalytic
NC16_RS14725	COG4575	ribosome binding
NC16_RS14730	COG1007	ATP synthesis coupled electron transport
NC16_RS14735	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NC16_RS14740	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NC16_RS14745	COG0713	ATP synthesis coupled electron transport
NC16_RS14750	COG0839	Belongs to the complex I subunit 6 family
NC16_RS14755	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NC16_RS14760	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
NC16_RS14775	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
NC16_RS14780	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NC16_RS14780	COG0649	NAD binding
NC16_RS14785	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NC16_RS14795	COG0583	DNA-binding transcription factor activity
NC16_RS14800	COG0436	Aminotransferase
NC16_RS14805	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
NC16_RS14810	COG0490	domain, Protein
NC16_RS14810	COG0471	metal ion transport
NC16_RS14815	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NC16_RS14820	COG3013	Belongs to the UPF0304 family
NC16_RS14825	COG3092	negative regulation of chromosome organization
NC16_RS14830	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
NC16_RS14835	COG0857	belongs to the CobB CobQ family
NC16_RS14835	COG0280	phosphate acetyltransferase
NC16_RS14845	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
NC16_RS14850	COG0622	Phosphoesterase
NC16_RS14855	COG0625	glutathione transferase activity
NC16_RS14860	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
NC16_RS14865	COG1090	epimerase
NC16_RS14870	COG3547	Transposase (IS116 IS110 IS902 family)
NC16_RS14875	COG4598	ABC transporter
NC16_RS14880	COG4160	amino acid transport
NC16_RS14895	COG0163	prenyltransferase activity
NC16_RS14900	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
NC16_RS14905	COG1286	toxin biosynthetic process
NC16_RS14910	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
NC16_RS14915	COG0285	dihydrofolate synthase activity
NC16_RS14920	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
NC16_RS14930	COG0586	Pfam SNARE associated Golgi protein
NC16_RS14935	COG0101	tRNA pseudouridine synthase activity
NC16_RS14940	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
NC16_RS14945	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NC16_RS14950	COG0697	spore germination
NC16_RS14960	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NC16_RS14965	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
NC16_RS14965	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NC16_RS14970	COG3547	Transposase (IS116 IS110 IS902 family)
NC16_RS14980	COG3101	peptidyl-lysine hydroxylation
NC16_RS14985	COG0730	response to heat
NC16_RS14990	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
NC16_RS14995	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
NC16_RS15000	COG2890	protein-(glutamine-N5) methyltransferase activity
NC16_RS15005	COG2840	Smr protein MutS2
NC16_RS15010	COG2062	phosphohistidine phosphatase, SixA
NC16_RS15040	COG1250	3-hydroxyacyl-CoA dehydrogenase
NC16_RS15040	COG1024	Enoyl-CoA hydratase
NC16_RS15045	COG0183	Belongs to the thiolase family
NC16_RS15055	COG4106	trans-aconitate 2-methyltransferase activity
NC16_RS15060	COG3691	Protein conserved in bacteria
NC16_RS15075	COG1028	Short-chain dehydrogenase reductase Sdr
NC16_RS15080	COG0583	DNA-binding transcription factor activity
NC16_RS15085	COG0579	oxidoreductase
NC16_RS15095	COG2116	formate transmembrane transporter activity
NC16_RS15130	COG1522	sequence-specific DNA binding
NC16_RS15135	COG2814	Major facilitator Superfamily
NC16_RS15175	COG0513	Belongs to the DEAD box helicase family
NC16_RS15185	COG1120	ATPase activity
NC16_RS15190	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NC16_RS15195	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NC16_RS15200	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NC16_RS15275	COG3866	Pectate lyase
NC16_RS15280	COG3266	domain, Protein
NC16_RS15290	COG0436	Aminotransferase
NC16_RS15295	COG4948	Mandelate Racemase Muconate Lactonizing
NC16_RS15305	COG3264	Mechanosensitive ion channel
NC16_RS15305	COG1511	domain protein
NC16_RS15315	COG0582	viral genome integration into host DNA
NC16_RS15325	COG5290	Psort location Cytoplasmic, score
NC16_RS15370	COG3596	GTP binding
NC16_RS15380	COG2378	regulation of single-species biofilm formation
NC16_RS15400	COG2003	Belongs to the UPF0758 family
NC16_RS15470	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NC16_RS15485	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NC16_RS15490	COG1696	Membrane protein involved in D-alanine export
NC16_RS15525	COG1447	Phosphotransferase system cellobiose-specific component IIA
NC16_RS15540	COG3842	ATPase activity
NC16_RS15545	COG2076	Multidrug Resistance protein
NC16_RS15550	COG2076	Multidrug Resistance protein
NC16_RS15555	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
NC16_RS15560	COG0726	polysaccharide deacetylase
NC16_RS15565	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NC16_RS15565	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
NC16_RS15570	COG0463	Glycosyl transferase, family 2
NC16_RS15575	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NC16_RS15580	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
NC16_RS15595	COG2203	Gaf domain
NC16_RS15595	COG3706	GGDEF domain
NC16_RS15595	COG5001	Diguanylate cyclase
NC16_RS15595	COG4251	negative regulation of phosphorylation
NC16_RS15600	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
NC16_RS15605	COG2501	S4 domain
NC16_RS15610	COG0215	cysteine-tRNA ligase activity
NC16_RS15620	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NC16_RS15625	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NC16_RS15630	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
NC16_RS15635	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
NC16_RS15640	COG0814	amino acid
NC16_RS15650	COG1760	l-serine dehydratase
NC16_RS15660	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NC16_RS15665	COG0581	inorganic phosphate transmembrane transporter activity
NC16_RS15670	COG0573	inorganic phosphate transmembrane transporter activity
NC16_RS15675	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
NC16_RS15695	COG1764	response to oxidative stress
NC16_RS15700	COG1846	Transcriptional regulator
NC16_RS15705	COG2239	Acts as a magnesium transporter
NC16_RS15720	COG1609	Transcriptional regulator
NC16_RS15725	COG4580	involved in the transport of maltose and maltodextrins
NC16_RS15730	COG3842	ATPase activity
NC16_RS15735	COG2182	Extracellular solute-binding protein
NC16_RS15740	COG1175	transmembrane transport
NC16_RS15745	COG3833	ABC-type maltose transport systems, permease component
NC16_RS15750	COG3867	Arabinogalactan endo-beta-1,4-galactanase
NC16_RS15755	COG1874	Beta-galactosidase
NC16_RS15765	COG3547	Transposase (IS116 IS110 IS902 family)
NC16_RS15780	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NC16_RS15785	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NC16_RS15790	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NC16_RS15795	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NC16_RS15800	COG0477	Major facilitator Superfamily
NC16_RS15805	COG2205	protein histidine kinase activity
NC16_RS15810	COG0745	RESPONSE REGULATOR receiver
NC16_RS15825	COG0435	Glutathione S-transferase
NC16_RS15830	COG0826	peptidase U32
NC16_RS15835	COG1597	lipid kinase activity
NC16_RS15840	COG3223	Belongs to the PsiE family
NC16_RS15850	COG0351	phosphomethylpyrimidine kinase
NC16_RS15855	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
NC16_RS15875	COG1064	alcohol dehydrogenase
NC16_RS15880	COG3706	GGDEF domain
NC16_RS15920	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
NC16_RS15950	COG0667	Aldo Keto reductase
NC16_RS15960	COG1309	transcriptional regulator
NC16_RS15965	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NC16_RS15965	COG0519	Catalyzes the synthesis of GMP from XMP
NC16_RS15975	COG1570	exodeoxyribonuclease VII activity
NC16_RS15990	COG1645	bacterial-type flagellum-dependent swarming motility
NC16_RS16005	COG1160	GTP binding
NC16_RS16010	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NC16_RS16015	COG2976	Protein conserved in bacteria
NC16_RS16020	COG0124	histidyl-tRNA synthetase
NC16_RS16025	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
NC16_RS16030	COG1426	Protein conserved in bacteria
NC16_RS16040	COG0820	rRNA (adenine-C2-)-methyltransferase activity
NC16_RS16045	COG0105	UTP biosynthetic process
NC16_RS16050	COG1263	PTS System
NC16_RS16050	COG2190	(PTS) system
NC16_RS16050	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NC16_RS16055	COG1486	melibiose metabolic process
NC16_RS16060	COG2897	thiosulfate sulfurtransferase activity
NC16_RS16065	COG1737	Transcriptional regulator
NC16_RS16075	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
NC16_RS16080	COG2975	iron-sulfur cluster assembly
NC16_RS16085	COG0633	Ferredoxin
NC16_RS16090	COG0443	Heat shock 70 kDa protein
NC16_RS16095	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
NC16_RS16100	COG0316	Belongs to the HesB IscA family
NC16_RS16105	COG0822	iron-sulfur transferase activity
NC16_RS16110	COG1104	cysteine desulfurase activity
NC16_RS16115	COG1959	2 iron, 2 sulfur cluster binding
NC16_RS16120	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
NC16_RS16125	COG0483	inositol monophosphate 1-phosphatase activity
NC16_RS16135	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NC16_RS16140	COG1120	ATPase activity
NC16_RS16150	COG0840	transmembrane signaling receptor activity
NC16_RS16160	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
NC16_RS16165	COG3683	transport system, periplasmic component
NC16_RS16170	COG2814	Major facilitator Superfamily
NC16_RS16175	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NC16_RS16180	COG1017	nitric oxide dioxygenase activity
NC16_RS16180	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NC16_RS16195	COG4677	pectinesterase activity
NC16_RS16200	COG0347	Belongs to the P(II) protein family
NC16_RS16205	COG2204	response regulator
NC16_RS16210	COG3170	Tfp pilus assembly protein FimV
NC16_RS16215	COG2205	protein histidine kinase activity
NC16_RS16220	COG0047	phosphoribosylformylglycinamidine synthase activity
NC16_RS16220	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NC16_RS16225	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
NC16_RS16235	COG0560	Phosphoserine phosphatase
NC16_RS16240	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
NC16_RS16250	COG2200	EAL domain
NC16_RS16250	COG2199	diguanylate cyclase activity
NC16_RS16250	COG3287	FIST C domain
NC16_RS16275	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NC16_RS16285	COG2200	EAL domain
NC16_RS16290	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
NC16_RS16295	COG0736	holo-[acyl-carrier-protein] synthase activity
NC16_RS16300	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
NC16_RS16305	COG1381	Involved in DNA repair and RecF pathway recombination
NC16_RS16310	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
NC16_RS16315	COG0571	ribonuclease III activity
NC16_RS16325	COG0481	GTPase activity
NC16_RS16330	COG3086	response to oxidative stress
NC16_RS16335	COG3026	antisigma factor binding
NC16_RS16350	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
NC16_RS16355	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
NC16_RS16360	COG0513	Belongs to the DEAD box helicase family
NC16_RS16365	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
NC16_RS16370	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
NC16_RS16385	COG2819	hydrolase of the alpha beta superfamily
NC16_RS16390	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NC16_RS16420	COG1902	pentaerythritol trinitrate reductase activity
NC16_RS16425	COG0667	Aldo Keto reductase
NC16_RS16440	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
NC16_RS16445	COG4208	sulfate ABC transporter
NC16_RS16455	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
NC16_RS16460	COG3835	regulator
NC16_RS16465	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NC16_RS16470	COG0232	Belongs to the dGTPase family. Type 2 subfamily
NC16_RS16475	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
NC16_RS16480	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NC16_RS16495	COG0316	Belongs to the HesB IscA family
NC16_RS16500	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
NC16_RS16505	COG0625	glutathione transferase activity
NC16_RS16510	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NC16_RS16520	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NC16_RS16525	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NC16_RS16530	COG1120	ATPase activity
NC16_RS16535	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NC16_RS16540	COG1643	Atp-dependent helicase
NC16_RS16545	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
NC16_RS16550	COG1489	DNA binding
NC16_RS16560	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NC16_RS16570	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
NC16_RS16575	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
NC16_RS16580	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
NC16_RS16585	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
NC16_RS16590	COG3547	Transposase (IS116 IS110 IS902 family)
NC16_RS16595	COG0842	Transport permease protein
NC16_RS16600	COG1131	(ABC) transporter
NC16_RS16605	COG0288	reversible hydration of carbon dioxide
NC16_RS16620	COG3842	ATPase activity
NC16_RS16635	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
NC16_RS16640	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
NC16_RS16645	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
NC16_RS16650	COG1780	Probably involved in ribonucleotide reductase function
NC16_RS16660	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NC16_RS16675	COG0328	RNA-DNA hybrid ribonuclease activity
NC16_RS16680	COG2226	methyltransferase
NC16_RS16685	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NC16_RS16690	COG1388	LysM domain
NC16_RS16690	COG0741	lytic transglycosylase activity
NC16_RS16695	COG3021	interspecies interaction between organisms
NC16_RS16730	COG0542	response to heat
NC16_RS16740	COG0564	pseudouridine synthase activity
NC16_RS16745	COG0564	pseudouridine synthase activity
NC16_RS16750	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NC16_RS16755	COG3385	transposase activity
NC16_RS16760	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
NC16_RS16765	COG1605	Chorismate mutase
NC16_RS16765	COG0077	Prephenate dehydratase
NC16_RS16770	COG0287	Prephenate dehydrogenase
NC16_RS16770	COG1605	Chorismate mutase
NC16_RS16775	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
NC16_RS16780	COG3279	Response regulator of the LytR AlgR family
NC16_RS16790	COG2264	protein methyltransferase activity
NC16_RS16800	COG0335	large ribosomal subunit rRNA binding
NC16_RS16805	COG0336	Belongs to the RNA methyltransferase TrmD family
NC16_RS16810	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
NC16_RS16815	COG0228	four-way junction DNA binding
NC16_RS16820	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
NC16_RS16825	COG4137	Cytochrome C assembly protein
NC16_RS16830	COG1854	S-ribosylhomocysteine lyase activity
NC16_RS16835	COG2918	glutathione biosynthetic process
NC16_RS16840	COG1238	metal cluster binding
NC16_RS16845	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NC16_RS16875	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
NC16_RS16880	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
NC16_RS16885	COG2137	regulation of response to DNA damage stimulus
NC16_RS16890	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
NC16_RS16895	COG1546	Belongs to the CinA family
NC16_RS16920	COG2814	Major facilitator Superfamily
NC16_RS16925	COG0583	DNA-binding transcription factor activity
NC16_RS16930	COG2999	glutathione oxidoreductase activity
NC16_RS16995	COG3209	COG3209 Rhs family protein
NC16_RS17000	COG3209	COG3209 Rhs family protein
NC16_RS17005	COG3209	COG3209 Rhs family protein
NC16_RS17010	COG3547	Transposase (IS116 IS110 IS902 family)
NC16_RS17015	COG3209	COG3209 Rhs family protein
NC16_RS17040	COG3501	Rhs element vgr protein
NC16_RS17075	COG3829	transcription factor binding
NC16_RS17175	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
NC16_RS17180	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
NC16_RS17205	COG1073	alpha beta
NC16_RS17210	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
NC16_RS17215	COG2195	Cleaves the N-terminal amino acid of tripeptides
NC16_RS17220	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NC16_RS17230	COG2226	methyltransferase
NC16_RS17235	COG3034	peptidoglycan biosynthetic process
NC16_RS17240	COG0121	glutamine amidotransferase
NC16_RS17245	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
NC16_RS17250	COG1960	acyl-CoA dehydrogenase activity
NC16_RS17260	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
NC16_RS17265	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
NC16_RS17305	COG3501	Rhs element vgr protein
NC16_RS17310	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
NC16_RS17315	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
NC16_RS17320	COG0235	Class ii aldolase
NC16_RS17325	COG0436	Aminotransferase
NC16_RS17345	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
NC16_RS17355	COG0765	amino acid transport
NC16_RS17400	COG4175	Glycine betaine
NC16_RS17405	COG4176	ABC-type proline glycine betaine transport system permease component
NC16_RS17410	COG2113	Glycine betaine
NC16_RS17415	COG0596	Alpha beta hydrolase
NC16_RS17425	COG2706	6-phosphogluconolactonase activity
NC16_RS17430	COG2814	Major facilitator Superfamily
NC16_RS17435	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
NC16_RS17445	COG1846	Transcriptional regulator
NC16_RS17450	COG1566	PFAM secretion protein HlyD family protein
NC16_RS17455	COG2814	Major facilitator Superfamily
NC16_RS17460	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NC16_RS17470	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NC16_RS17475	COG3118	belongs to the thioredoxin family
NC16_RS17480	COG3148	PFAM DTW domain containing protein
NC16_RS17485	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NC16_RS17485	COG0045	succinate-CoA ligase (ADP-forming) activity
NC16_RS17485	COG1042	CoA-binding domain protein
NC16_RS17490	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NC16_RS17495	COG0477	Major facilitator Superfamily
NC16_RS17530	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
NC16_RS17535	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
NC16_RS17540	COG2011	ABC-type metal ion transport system permease component
NC16_RS17545	COG1464	Belongs to the NlpA lipoprotein family
NC16_RS17555	COG1720	tRNA m6t6A37 methyltransferase activity
NC16_RS17560	COG0442	prolyl-tRNA aminoacylation
NC16_RS17570	COG4942	peptidase
NC16_RS17570	COG1388	LysM domain
NC16_RS17575	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
NC16_RS17580	COG0585	pseudouridine synthase activity
NC16_RS17585	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
NC16_RS17590	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
NC16_RS17595	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
NC16_RS17605	COG0765	amino acid transport
NC16_RS17610	COG1126	abc transporter atp-binding protein
NC16_RS17620	COG0529	Catalyzes the synthesis of activated sulfate
NC16_RS17625	COG2895	sulfate adenylyltransferase (ATP) activity
NC16_RS17630	COG0175	sulfate reduction
NC16_RS17635	COG1648	precorrin-2 dehydrogenase activity
NC16_RS17635	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NC16_RS17640	COG0584	glycerophosphoryl diester phosphodiesterase
NC16_RS17645	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NC16_RS17660	COG0444	Belongs to the ABC transporter superfamily
NC16_RS17670	COG0175	sulfate reduction
NC16_RS17675	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NC16_RS17680	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
NC16_RS17690	COG2200	EAL domain
NC16_RS17710	COG0720	synthase
NC16_RS17715	COG0602	queuosine metabolic process
NC16_RS17720	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NC16_RS17725	COG1028	Short-chain dehydrogenase reductase Sdr
NC16_RS17730	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
NC16_RS17740	COG0583	DNA-binding transcription factor activity
NC16_RS17755	COG0148	phosphopyruvate hydratase activity
NC16_RS17760	COG0504	CTP synthase activity
NC16_RS17765	COG3956	TIGRFAM MazG family protein
NC16_RS17770	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NC16_RS17775	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NC16_RS17785	COG1929	Belongs to the glycerate kinase type-1 family
NC16_RS17790	COG2084	Dehydrogenase
NC16_RS17800	COG4948	Mandelate Racemase Muconate Lactonizing
NC16_RS17805	COG4948	Mandelate Racemase Muconate Lactonizing
NC16_RS17810	COG2271	Major facilitator Superfamily
NC16_RS17815	COG2721	sulfolactate sulfo-lyase activity
NC16_RS17825	COG0840	transmembrane signaling receptor activity
NC16_RS17840	COG3530	Putative quorum-sensing-regulated virulence factor
NC16_RS17845	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NC16_RS17850	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
NC16_RS17850	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
NC16_RS17855	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
NC16_RS17860	COG3025	triphosphatase activity
NC16_RS17865	COG4991	sh3 domain protein
NC16_RS17870	COG0617	tRNA 3'-terminal CCA addition
NC16_RS17875	COG1968	undecaprenyl-diphosphatase activity
NC16_RS17885	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
NC16_RS17890	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
NC16_RS17895	COG0840	transmembrane signaling receptor activity
NC16_RS17900	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
NC16_RS17905	COG2105	PFAM AIG2 family protein
NC16_RS17910	COG2911	Protein conserved in bacteria
NC16_RS17915	COG0729	surface antigen
NC16_RS17920	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NC16_RS17925	COG1253	flavin adenine dinucleotide binding
NC16_RS17935	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
NC16_RS17940	COG1218	3'(2'),5'-bisphosphate nucleotidase
NC16_RS17945	COG0737	Belongs to the 5'-nucleotidase family
NC16_RS17950	COG1733	regulation of RNA biosynthetic process
NC16_RS17965	COG3961	Belongs to the TPP enzyme family
NC16_RS17970	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
NC16_RS17975	COG0545	Peptidyl-prolyl cis-trans isomerase
NC16_RS17980	COG3061	Opacity-associated protein A
NC16_RS17990	COG0359	binds to the 23S rRNA
NC16_RS17995	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
NC16_RS18000	COG2965	DNA replication, synthesis of RNA primer
NC16_RS18005	COG0360	Binds together with S18 to 16S ribosomal RNA
NC16_RS18010	COG1073	alpha beta
NC16_RS18015	COG0840	transmembrane signaling receptor activity
NC16_RS18020	COG1690	Belongs to the RtcB family
NC16_RS18025	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
NC16_RS18040	COG3766	membrane
NC16_RS18045	COG0840	transmembrane signaling receptor activity
NC16_RS18050	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NC16_RS18055	COG0557	exoribonuclease II activity
NC16_RS18060	COG1959	2 iron, 2 sulfur cluster binding
NC16_RS18065	COG0840	transmembrane signaling receptor activity
NC16_RS18075	COG2805	Type II/IV secretion system protein
NC16_RS18080	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
NC16_RS18085	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NC16_RS18090	COG0762	integral membrane protein
NC16_RS18095	COG1872	DUF167
NC16_RS18100	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
NC16_RS18105	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NC16_RS18130	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
NC16_RS18130	COG0456	acetyltransferase
NC16_RS18140	COG2153	protein acetylation
NC16_RS18145	COG0477	Major facilitator Superfamily
NC16_RS18150	COG0318	PFAM AMP-dependent synthetase and ligase
NC16_RS18150	COG0204	Acyl-transferase
NC16_RS18170	COG2186	Transcriptional regulator
NC16_RS18175	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NC16_RS18180	COG2723	6-phospho-beta-galactosidase activity
NC16_RS18185	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NC16_RS18190	COG1447	Phosphotransferase system cellobiose-specific component IIA
NC16_RS18215	COG0583	DNA-binding transcription factor activity
NC16_RS18220	COG0583	DNA-binding transcription factor activity
NC16_RS18240	COG2801	Transposase and inactivated derivatives
NC16_RS18250	COG4735	regulation of single-species biofilm formation
NC16_RS18255	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NC16_RS18265	COG2124	cytochrome p450
NC16_RS18280	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NC16_RS18300	COG1522	sequence-specific DNA binding
NC16_RS18310	COG1448	Aminotransferase
NC16_RS18315	COG1451	nucleotide metabolic process
NC16_RS18340	COG1518	maintenance of DNA repeat elements
NC16_RS18345	COG1203	CRISPR-associated helicase, Cas3
NC16_RS18370	COG0432	Pfam Uncharacterised protein family UPF0047
NC16_RS18380	COG0629	single-stranded DNA binding
NC16_RS18410	COG0395	ABC-type sugar transport system, permease component
NC16_RS18415	COG1175	transmembrane transport
NC16_RS18420	COG3842	ATPase activity
NC16_RS18425	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
NC16_RS18445	COG2971	BadF BadG BcrA BcrD
NC16_RS18455	COG1121	(ABC) transporter
NC16_RS18460	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NC16_RS18465	COG0803	Belongs to the bacterial solute-binding protein 9 family
NC16_RS18475	COG1349	DNA-binding transcription factor activity
NC16_RS18480	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
NC16_RS18485	COG3395	kinase activity
NC16_RS18490	COG1454	alcohol dehydrogenase
NC16_RS18495	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NC16_RS18510	COG2731	YhcH YjgK YiaL family protein
NC16_RS18520	COG1609	Transcriptional regulator
NC16_RS18525	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NC16_RS18540	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NC16_RS18545	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NC16_RS18550	COG0765	amino acid transport
NC16_RS18560	COG0765	amino acid transport
NC16_RS18565	COG3112	Uncharacterised protein family (UPF0231)
NC16_RS18580	COG0640	Transcriptional regulator
NC16_RS18585	COG4771	TonB-dependent receptor
NC16_RS18595	COG2079	MmgE PrpD family protein
NC16_RS18605	COG1073	alpha beta
NC16_RS18610	COG2814	Major facilitator Superfamily
NC16_RS18620	COG0583	DNA-binding transcription factor activity
NC16_RS18625	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NC16_RS18630	COG0508	dehydrogenase complex catalyzes the overall conversion of
NC16_RS18635	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
NC16_RS18645	COG1113	amino acid transport
NC16_RS18650	COG2211	Major facilitator Superfamily
NC16_RS18655	COG3940	Belongs to the glycosyl hydrolase 43 family
NC16_RS18660	COG3725	Membrane protein required for beta-lactamase induction
NC16_RS18665	COG3023	N-Acetylmuramoyl-L-alanine amidase
NC16_RS18670	COG3248	Nucleoside-binding outer membrane protein
NC16_RS18675	COG0157	Belongs to the NadC ModD family
NC16_RS18680	COG4969	Belongs to the N-Me-Phe pilin family
NC16_RS18685	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NC16_RS18690	COG1459	type II secretion system
NC16_RS18695	COG0516	GMP reductase activity
NC16_RS18700	COG0237	dephospho-CoA kinase activity
NC16_RS18705	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
NC16_RS18710	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
NC16_RS18715	COG0494	nUDIX hydrolase
NC16_RS18720	COG0653	protein targeting
NC16_RS18735	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
NC16_RS18740	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
NC16_RS18745	COG0849	cell division
NC16_RS18750	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
NC16_RS18755	COG1181	Belongs to the D-alanine--D-alanine ligase family
NC16_RS18760	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NC16_RS18765	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NC16_RS18770	COG0772	Belongs to the SEDS family
NC16_RS18775	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
NC16_RS18780	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NC16_RS18785	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
NC16_RS18790	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
NC16_RS18795	COG0768	penicillin binding
NC16_RS18800	COG3116	cell division
NC16_RS18805	COG0275	rRNA processing
NC16_RS18810	COG2001	Belongs to the MraZ family
NC16_RS18830	COG0028	Belongs to the TPP enzyme family
NC16_RS18835	COG1022	Amp-dependent synthetase and ligase
NC16_RS18840	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NC16_RS18845	COG0473	3-isopropylmalate dehydrogenase activity
NC16_RS18850	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
NC16_RS18855	COG0066	3-isopropylmalate dehydratase activity
NC16_RS18875	COG0840	transmembrane signaling receptor activity
NC16_RS18885	COG3033	Beta-eliminating lyase
NC16_RS18905	COG4533	DNA binding
NC16_RS18910	COG4143	(ABC) transporter
NC16_RS18915	COG1178	ABC-type Fe3 transport system permease component
NC16_RS18920	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
NC16_RS18925	COG3507	Belongs to the glycosyl hydrolase 43 family
NC16_RS18940	COG0028	Belongs to the TPP enzyme family
NC16_RS18945	COG0440	acetolactate synthase activity
NC16_RS18950	COG0586	Pfam SNARE associated Golgi protein
NC16_RS18955	COG3706	GGDEF domain
NC16_RS18960	COG0417	DNA replication proofreading
NC16_RS18965	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NC16_RS18970	COG0564	pseudouridine synthase activity
NC16_RS18975	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
NC16_RS18980	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
NC16_RS18985	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NC16_RS18990	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
NC16_RS18995	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
NC16_RS19000	COG2967	ApaG domain
NC16_RS19005	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
NC16_RS19025	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NC16_RS19030	COG3610	response to peptide
NC16_RS19035	COG2966	Psort location CytoplasmicMembrane, score
NC16_RS19045	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
NC16_RS19050	COG0505	Belongs to the CarA family
NC16_RS19055	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
NC16_RS19065	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
NC16_RS19070	COG1047	Peptidyl-prolyl cis-trans
NC16_RS19080	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
NC16_RS19085	COG0196	riboflavin kinase activity
NC16_RS19090	COG0268	Binds directly to 16S ribosomal RNA
NC16_RS19095	COG0583	DNA-binding transcription factor activity
NC16_RS19100	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
NC16_RS19105	COG0484	heat shock protein binding
NC16_RS19110	COG0443	Heat shock 70 kDa protein
NC16_RS19115	COG1584	GPR1 FUN34 yaaH family protein
NC16_RS19125	COG0521	Mo-molybdopterin cofactor biosynthetic process
NC16_RS19135	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NC16_RS19140	COG3022	response to hydroperoxide
NC16_RS19150	COG0083	homoserine kinase activity
NC16_RS19165	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
NC16_RS19170	COG0745	RESPONSE REGULATOR receiver
NC16_RS19175	COG3045	CreA protein
NC16_RS19180	COG2207	Transcriptional regulator
NC16_RS19180	COG3708	Transcriptional regulator
NC16_RS19190	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
NC16_RS19195	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
NC16_RS19205	COG0488	(ABC) transporter
NC16_RS19210	COG0840	transmembrane signaling receptor activity
NC16_RS19215	COG0583	DNA-binding transcription factor activity
NC16_RS19220	COG0604	alcohol dehydrogenase
NC16_RS19225	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NC16_RS19230	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
NC16_RS19235	COG0583	DNA-binding transcription factor activity
NC16_RS19245	COG1279	arginine transmembrane transporter activity
NC16_RS19250	COG0668	transmembrane transport
NC16_RS19255	COG0191	fructose-bisphosphate aldolase activity
NC16_RS19260	COG0126	phosphoglycerate kinase activity
NC16_RS19265	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NC16_RS19270	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
NC16_RS19275	COG0501	Belongs to the peptidase M48B family
NC16_RS19285	COG1166	arginine decarboxylase activity
NC16_RS19290	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
NC16_RS19295	COG3091	SprT-like family
NC16_RS19300	COG2356	endonuclease I
NC16_RS19305	COG1385	rRNA (uridine-N3-)-methyltransferase activity
NC16_RS19310	COG0189	ligase activity
NC16_RS19315	COG1678	Uncharacterized ACR, COG1678
NC16_RS19320	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
NC16_RS19325	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
NC16_RS19330	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NC16_RS19335	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
NC16_RS19340	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
NC16_RS19345	COG0330	HflC and HflK could
NC16_RS19350	COG0330	HflC and HflK could
NC16_RS19355	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
NC16_RS19360	COG1923	regulation of RNA biosynthetic process
NC16_RS19365	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
NC16_RS19370	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
NC16_RS19380	COG0802	atpase or kinase
NC16_RS19385	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
NC16_RS19385	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
NC16_RS19390	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
NC16_RS19405	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
NC16_RS19445	COG1704	LemA family
NC16_RS19450	COG1064	alcohol dehydrogenase
NC16_RS19470	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
NC16_RS19475	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NC16_RS19485	COG1011	Hydrolase
NC16_RS19530	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
NC16_RS19535	COG1162	GTPase activity
NC16_RS19540	COG0688	phosphatidylethanolamine metabolic process
NC16_RS19545	COG1511	domain protein
NC16_RS19545	COG3264	Mechanosensitive ion channel
NC16_RS19550	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
NC16_RS19555	COG1053	succinate dehydrogenase
NC16_RS19560	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
NC16_RS19565	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
NC16_RS19570	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
NC16_RS19575	COG3040	lipid binding
NC16_RS19590	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
NC16_RS19595	COG1509	lysine 2,3-aminomutase activity
NC16_RS19605	COG0166	Belongs to the GPI family
NC16_RS19610	COG0527	aspartate kinase activity
NC16_RS19620	COG0471	metal ion transport
NC16_RS19630	COG2207	Transcriptional regulator
NC16_RS19645	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
NC16_RS19655	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
NC16_RS19660	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
NC16_RS19685	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
NC16_RS19695	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NC16_RS19700	COG0009	L-threonylcarbamoyladenylate synthase
NC16_RS19705	COG0551	DNA topoisomerase type I activity
NC16_RS19710	COG2922	Belongs to the Smg family
NC16_RS19715	COG0758	DNA mediated transformation
NC16_RS19720	COG0242	peptide deformylase activity
NC16_RS19725	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
NC16_RS19730	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
NC16_RS19730	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NC16_RS19735	COG0569	domain protein
NC16_RS19740	COG1970	mechanosensitive ion channel activity
NC16_RS19745	COG3036	rescue of stalled ribosome
NC16_RS19750	COG0203	ribosomal protein L17
NC16_RS19755	COG0202	RNA polymerase activity
NC16_RS19760	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
NC16_RS19770	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
NC16_RS19775	COG0257	Belongs to the bacterial ribosomal protein bL36 family
NC16_RS19780	COG0201	protein transport
NC16_RS19785	COG0200	Binds to the 23S rRNA
NC16_RS19790	COG1841	ribosomal large subunit assembly
NC16_RS19795	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
NC16_RS19800	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
NC16_RS19805	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
NC16_RS19810	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
NC16_RS19815	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
NC16_RS19820	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
NC16_RS19825	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
NC16_RS19835	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
NC16_RS19840	COG0255	Belongs to the universal ribosomal protein uL29 family
NC16_RS19845	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
NC16_RS19850	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
NC16_RS19855	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
NC16_RS19860	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
NC16_RS19865	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
NC16_RS19875	COG0088	Forms part of the polypeptide exit tunnel
NC16_RS19880	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
NC16_RS19885	COG0051	transcription antitermination factor activity, RNA binding
NC16_RS19890	COG2193	ferroxidase activity
NC16_RS19905	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NC16_RS19910	COG0049	tRNA binding
NC16_RS19915	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
NC16_RS19920	COG2168	tRNA wobble position uridine thiolation
NC16_RS19925	COG2923	Belongs to the DsrF TusC family
NC16_RS19930	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
NC16_RS19935	COG2964	Protein conserved in bacteria
NC16_RS19945	COG0745	RESPONSE REGULATOR receiver
NC16_RS19950	COG0642	Histidine kinase
NC16_RS19955	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NC16_RS19970	COG0545	Peptidyl-prolyl cis-trans isomerase
NC16_RS19975	COG2900	Belongs to the SlyX family
NC16_RS19980	COG1047	Peptidyl-prolyl cis-trans
NC16_RS19985	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
NC16_RS19995	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NC16_RS19995	COG0475	glutathione-regulated potassium exporter activity
NC16_RS20000	COG2249	NAD(P)H dehydrogenase (quinone) activity
NC16_RS20005	COG0488	(ABC) transporter
NC16_RS20015	COG0429	hydrolase of the alpha beta-hydrolase fold
NC16_RS20020	COG3089	Belongs to the UPF0270 family
NC16_RS20025	COG3954	Phosphoribulokinase
NC16_RS20030	COG1765	OsmC-like protein
NC16_RS20035	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NC16_RS20055	COG3866	Pectate lyase
NC16_RS20075	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NC16_RS20080	COG4608	Belongs to the ABC transporter superfamily
NC16_RS20085	COG0444	Belongs to the ABC transporter superfamily
NC16_RS20090	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NC16_RS20095	COG0601	transmembrane transport
NC16_RS20100	COG0747	negative chemotaxis
NC16_RS20105	COG4948	Mandelate Racemase Muconate Lactonizing
NC16_RS20110	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NC16_RS20120	COG1648	precorrin-2 dehydrogenase activity
NC16_RS20120	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NC16_RS20145	COG1473	amidohydrolase
NC16_RS20155	COG0546	phosphoglycolate phosphatase activity
NC16_RS20160	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
NC16_RS20175	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
NC16_RS20180	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
NC16_RS20185	COG4796	Type ii and iii secretion system protein
NC16_RS20210	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
NC16_RS20220	COG0494	nUDIX hydrolase
NC16_RS20235	COG1011	Hydrolase
NC16_RS20240	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
NC16_RS20245	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
NC16_RS20250	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
NC16_RS20275	COG2814	Major facilitator Superfamily
NC16_RS20280	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
NC16_RS20285	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NC16_RS20290	COG0019	diaminopimelate decarboxylase activity
NC16_RS20295	COG4774	siderophore transport
NC16_RS20300	COG4264	IucA IucC family
NC16_RS20310	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NC16_RS20325	COG0840	transmembrane signaling receptor activity
NC16_RS20335	COG2183	response to ionizing radiation
NC16_RS20340	COG1414	Transcriptional regulator
NC16_RS20365	COG1262	PFAM Formylglycine-generating sulfatase enzyme
NC16_RS20365	COG0515	serine threonine protein kinase
NC16_RS20385	COG1785	Belongs to the alkaline phosphatase family
NC16_RS20395	COG2002	toxin-antitoxin pair type II binding
NC16_RS20400	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NC16_RS20405	COG2267	carboxylic ester hydrolase activity
NC16_RS20410	COG1040	competence protein
NC16_RS20415	COG0316	Belongs to the HesB IscA family
NC16_RS20415	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
NC16_RS20420	COG1640	4-alpha-glucanotransferase
NC16_RS20425	COG0058	SHG alpha-glucan phosphorylase activity
NC16_RS20430	COG1349	DNA-binding transcription factor activity
NC16_RS20435	COG0705	Rhomboid family
NC16_RS20440	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NC16_RS20445	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
NC16_RS20450	COG0058	SHG alpha-glucan phosphorylase activity
NC16_RS20455	COG0297	glycogen (starch) synthase activity
NC16_RS20460	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
NC16_RS20465	COG1523	belongs to the glycosyl hydrolase 13 family
NC16_RS20470	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
NC16_RS20475	COG3275	phosphorelay sensor kinase activity
NC16_RS20485	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
NC16_RS20490	COG2095	MarC family integral membrane protein
NC16_RS20495	COG2610	gluconate transmembrane transporter activity
NC16_RS20500	COG3265	gluconokinase activity
NC16_RS20505	COG1609	Transcriptional regulator
NC16_RS20510	COG1741	Belongs to the pirin family
NC16_RS20525	COG0247	lactate metabolic process
NC16_RS20530	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
NC16_RS20535	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
NC16_RS20540	COG2271	Major facilitator Superfamily
NC16_RS20545	COG0584	glycerophosphoryl diester phosphodiesterase
NC16_RS20550	COG0561	phosphatase activity
NC16_RS20555	COG2267	carboxylic ester hydrolase activity
NC16_RS20560	COG1280	lysine exporter protein (LysE YggA)
NC16_RS20565	COG1280	lysine exporter protein (LysE YggA)
NC16_RS20570	COG0514	ATP-dependent DNA helicase (RecQ)
NC16_RS20580	COG2050	protein possibly involved in aromatic compounds catabolism
NC16_RS20590	COG3180	Ammonia monooxygenase
NC16_RS20595	COG0598	Magnesium transport protein CorA
NC16_RS20600	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
NC16_RS20605	COG0210	DNA helicase
NC16_RS20610	COG1011	Hydrolase
NC16_RS20625	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
NC16_RS20635	COG1965	Belongs to the frataxin family
NC16_RS20640	COG2814	Major facilitator Superfamily
NC16_RS20655	COG0181	hydroxymethylbilane synthase activity
NC16_RS20660	COG1587	Uroporphyrinogen-III synthase
NC16_RS20665	COG2959	enzyme of heme biosynthesis
NC16_RS20670	COG3071	HemY protein
NC16_RS20675	COG1473	amidohydrolase
NC16_RS20680	COG1126	abc transporter atp-binding protein
NC16_RS20685	COG0765	amino acid transport
NC16_RS20690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NC16_RS20695	COG0456	acetyltransferase
NC16_RS20700	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
NC16_RS20735	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
NC16_RS20745	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
NC16_RS20750	COG2244	polysaccharide biosynthetic process
NC16_RS20755	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NC16_RS20760	COG0456	acetyltransferase
NC16_RS20765	COG1088	dTDP-glucose 4,6-dehydratase activity
NC16_RS20770	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
NC16_RS20775	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
NC16_RS20780	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
NC16_RS20785	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NC16_RS20790	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
NC16_RS20795	COG3118	belongs to the thioredoxin family
NC16_RS20800	COG0513	Belongs to the DEAD box helicase family
NC16_RS20805	COG0248	Ppx GppA phosphatase
NC16_RS20810	COG0210	DNA helicase
NC16_RS20815	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NC16_RS20820	COG0506	proline dehydrogenase activity
NC16_RS20820	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
NC16_RS20820	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
NC16_RS20830	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
NC16_RS20835	COG0583	DNA-binding transcription factor activity
NC16_RS20875	COG0129	dihydroxy-acid dehydratase activity
NC16_RS20885	COG3978	acetolactate synthase activity
NC16_RS20905	COG3085	chromosome segregation
NC16_RS20910	COG0583	DNA-binding transcription factor activity
NC16_RS20915	COG1172	Belongs to the binding-protein-dependent transport system permease family
NC16_RS20920	COG1172	Belongs to the binding-protein-dependent transport system permease family
NC16_RS20925	COG1129	ABC transporter
NC16_RS20930	COG1879	ABC-type sugar transport system periplasmic component
NC16_RS20980	COG1739	Uncharacterized protein family UPF0029
NC16_RS20985	COG0006	proline dipeptidase activity
NC16_RS20990	COG1250	3-hydroxyacyl-CoA dehydrogenase
NC16_RS20990	COG1024	Enoyl-CoA hydratase
NC16_RS20995	COG0183	Belongs to the thiolase family
NC16_RS21005	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
NC16_RS21010	COG0250	Participates in transcription elongation, termination and antitermination
NC16_RS21020	COG0084	hydrolase, TatD family'
NC16_RS21025	COG0805	protein transport
NC16_RS21030	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NC16_RS21035	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NC16_RS21040	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
NC16_RS21050	COG2226	methyltransferase
NC16_RS21055	COG1322	Protein conserved in bacteria
NC16_RS21060	COG0165	Argininosuccinate lyase
NC16_RS21065	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
NC16_RS21070	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
NC16_RS21075	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NC16_RS21080	COG2188	Transcriptional regulator
NC16_RS21085	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
NC16_RS21090	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
NC16_RS21115	COG4948	Mandelate Racemase Muconate Lactonizing
NC16_RS21120	COG1263	PTS System
NC16_RS21120	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NC16_RS21120	COG2190	(PTS) system
NC16_RS21130	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
NC16_RS21155	COG0412	Dienelactone hydrolase
NC16_RS21160	COG0840	transmembrane signaling receptor activity
NC16_RS21165	COG0840	transmembrane signaling receptor activity
NC16_RS21170	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
NC16_RS21175	COG0583	DNA-binding transcription factor activity
NC16_RS21190	COG1045	serine acetyltransferase
NC16_RS21195	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
NC16_RS21200	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
NC16_RS21205	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NC16_RS21210	COG4942	peptidase
NC16_RS21215	COG2861	carbohydrate metabolic process
NC16_RS21220	COG1063	alcohol dehydrogenase
NC16_RS21225	COG0156	8-amino-7-oxononanoate synthase activity
NC16_RS21230	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NC16_RS21240	COG0859	PFAM glycosyl transferase family 9
NC16_RS21245	COG3307	-O-antigen
NC16_RS21250	COG0859	PFAM glycosyl transferase family 9
NC16_RS21255	COG0438	transferase activity, transferring glycosyl groups
NC16_RS21265	COG3306	glycosyltransferase involved in LPS biosynthesis
NC16_RS21300	COG1519	Transferase
NC16_RS21305	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
NC16_RS21310	COG0859	PFAM glycosyl transferase family 9
NC16_RS21315	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NC16_RS21325	COG0227	Belongs to the bacterial ribosomal protein bL28 family
NC16_RS21330	COG2003	Belongs to the UPF0758 family
NC16_RS21335	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
NC16_RS21340	COG0756	dUTP diphosphatase activity
NC16_RS21345	COG1309	transcriptional regulator
NC16_RS21350	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
NC16_RS21355	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
NC16_RS21360	COG4948	Mandelate Racemase Muconate Lactonizing
NC16_RS21365	COG4172	Belongs to the ABC transporter superfamily
NC16_RS21370	COG0747	negative chemotaxis
NC16_RS21375	COG0601	transmembrane transport
NC16_RS21380	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NC16_RS21395	COG1446	asparaginase
NC16_RS21400	COG0583	DNA-binding transcription factor activity
NC16_RS21405	COG1561	YicC-like family, N-terminal region
NC16_RS21470	COG0628	permease
NC16_RS21475	COG1304	FMN binding
NC16_RS21480	COG1012	belongs to the aldehyde dehydrogenase family
NC16_RS21490	COG3239	Fatty acid desaturase
NC16_RS21520	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NC16_RS21525	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NC16_RS21535	COG3136	membrane protein required for alginate biosynthesis
NC16_RS21545	COG2207	Transcriptional regulator
NC16_RS21550	COG4677	pectinesterase activity
NC16_RS21555	COG2771	luxR family
NC16_RS21565	COG0137	argininosuccinate synthase activity
NC16_RS21575	COG1609	Transcriptional regulator
NC16_RS21575	COG2207	Transcriptional regulator
NC16_RS21580	COG4214	carbohydrate transport
NC16_RS21585	COG1129	ABC transporter
NC16_RS21590	COG4213	ABC transporter substrate-binding protein
NC16_RS21595	COG2115	Belongs to the xylose isomerase family
NC16_RS21600	COG1070	Carbohydrate kinase
NC16_RS21605	COG3274	enterobacterial common antigen metabolic process
NC16_RS21610	COG1012	belongs to the aldehyde dehydrogenase family
NC16_RS21620	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
NC16_RS21625	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
NC16_RS21630	COG0840	transmembrane signaling receptor activity
NC16_RS21640	COG3722	fumarate hydratase activity
NC16_RS21645	COG0246	Mannitol dehydrogenase
NC16_RS21650	COG2213	PTS system mannitol-specific
NC16_RS21650	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
NC16_RS21660	COG0751	glycine-tRNA ligase activity
NC16_RS21665	COG0752	glycyl-tRNA synthetase alpha subunit
NC16_RS21670	COG0730	response to heat
NC16_RS21675	COG2818	Glycosylase
NC16_RS21680	COG0456	acetyltransferase
NC16_RS21685	COG0840	transmembrane signaling receptor activity
NC16_RS21690	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NC16_RS21705	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NC16_RS21710	COG4172	Belongs to the ABC transporter superfamily
NC16_RS21715	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NC16_RS21730	COG3479	Phenolic acid decarboxylase
NC16_RS21740	COG1280	lysine exporter protein (LysE YggA)
NC16_RS21745	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NC16_RS21765	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NC16_RS21770	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
NC16_RS21780	COG2214	Heat shock protein DnaJ domain protein
NC16_RS21785	COG0443	Heat shock 70 kDa protein
NC16_RS21810	COG0742	ribosomal rna small subunit methyltransferase
NC16_RS21815	COG0737	Belongs to the 5'-nucleotidase family
NC16_RS21825	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NC16_RS21830	COG0589	response to stress
NC16_RS21845	COG0306	phosphate transporter
NC16_RS21850	COG2081	HI0933 family
NC16_RS21855	COG2200	EAL domain
NC16_RS21870	COG2194	sulfuric ester hydrolase activity
NC16_RS21875	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NC16_RS21880	COG0194	GDP metabolic process
NC16_RS21885	COG1758	RNA polymerase activity
NC16_RS21890	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NC16_RS21895	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NC16_RS21900	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
NC16_RS21905	COG2233	PERMEase
NC16_RS21910	COG2982	Protein involved in outer membrane biogenesis
NC16_RS21915	COG0456	acetyltransferase
NC16_RS21920	COG1490	D-aminoacyl-tRNA deacylase activity
NC16_RS21925	COG1011	Hydrolase
NC16_RS21940	COG3852	Histidine kinase
NC16_RS21955	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NC16_RS21960	COG3078	GTPase activator activity
NC16_RS21970	COG0218	Necessary for normal cell division and for the maintenance of normal septation
NC16_RS21975	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NC16_RS21975	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NC16_RS21985	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
NC16_RS21990	COG3084	Protein conserved in bacteria
NC16_RS21995	COG0746	molybdenum cofactor guanylyltransferase activity
NC16_RS22000	COG1763	Mo-molybdopterin cofactor biosynthetic process
NC16_RS22025	COG1609	Transcriptional regulator
NC16_RS22030	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NC16_RS22040	COG1172	Belongs to the binding-protein-dependent transport system permease family
NC16_RS22045	COG1129	ABC transporter
NC16_RS22050	COG1869	D-ribose catabolic process
NC16_RS22055	COG3111	PFAM Bacterial OB fold (BOF) protein
NC16_RS22065	COG0642	Histidine kinase
NC16_RS22070	COG3158	transport of potassium into the cell
NC16_RS22075	COG0714	Associated with various cellular activities
NC16_RS22080	COG2425	protein containing a von Willebrand factor type A (vWA) domain
NC16_RS22085	COG2502	aspartate--ammonia ligase
NC16_RS22090	COG1522	sequence-specific DNA binding
NC16_RS22095	COG0716	FMN binding
NC16_RS22100	COG0445	tRNA wobble uridine modification
NC16_RS22105	COG0357	Ribosomal RNA small subunit methyltransferase G
NC16_RS22110	COG3312	ion transport
NC16_RS22115	COG0356	it plays a direct role in the translocation of protons across the membrane
NC16_RS22125	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
NC16_RS22130	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NC16_RS22135	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
NC16_RS22140	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
NC16_RS22145	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
NC16_RS22150	COG0355	proton-transporting ATP synthase activity, rotational mechanism
NC16_RS22160	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
NC16_RS22165	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NC16_RS22190	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NC16_RS22195	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NC16_RS22205	COG0318	PFAM AMP-dependent synthetase and ligase
NC16_RS22210	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
NC16_RS22210	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
NC16_RS22215	COG1216	Glycosyl transferase, family 2
NC16_RS22240	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NC16_RS22250	COG1028	Short-chain dehydrogenase reductase Sdr
NC16_RS22265	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
NC16_RS22270	COG0573	inorganic phosphate transmembrane transporter activity
NC16_RS22275	COG0581	inorganic phosphate transmembrane transporter activity
NC16_RS22280	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NC16_RS22290	COG1396	sequence-specific DNA binding
NC16_RS22295	COG3135	benzoate transporter
NC16_RS22300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NC16_RS22305	COG0765	amino acid transport
NC16_RS22310	COG0765	amino acid transport
NC16_RS22315	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NC16_RS22320	COG2252	PERMEase
NC16_RS22325	COG2091	lysine biosynthetic process via aminoadipic acid
NC16_RS22330	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
NC16_RS22335	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
NC16_RS22335	COG0493	'glutamate synthase
NC16_RS22365	COG1733	regulation of RNA biosynthetic process
NC16_RS22370	COG0702	epimerase
NC16_RS22380	COG1396	sequence-specific DNA binding
NC16_RS22385	COG3550	peptidyl-serine autophosphorylation
NC16_RS22410	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
NC16_RS22415	COG0706	membrane insertase activity
NC16_RS22425	COG0594	ribonuclease P activity
NC16_RS22430	COG0230	Belongs to the bacterial ribosomal protein bL34 family