locus-tag	class	description
A8F97_RS00005	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
A8F97_RS00005	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A8F97_RS00010	COG1120	ATPase activity
A8F97_RS00015	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A8F97_RS00020	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A8F97_RS00025	COG0477	Major facilitator Superfamily
A8F97_RS00030	COG4592	Periplasmic binding protein
A8F97_RS00035	COG3112	Uncharacterised protein family (UPF0231)
A8F97_RS00040	COG1349	DNA-binding transcription factor activity
A8F97_RS00050	COG1129	ABC transporter
A8F97_RS00055	COG1172	Belongs to the binding-protein-dependent transport system permease family
A8F97_RS00065	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A8F97_RS00070	COG1940	carbohydrate kinase activity
A8F97_RS00075	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A8F97_RS00090	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A8F97_RS00095	COG1882	Formate acetyltransferase
A8F97_RS00105	COG2731	YhcH YjgK YiaL family protein
A8F97_RS00120	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A8F97_RS00125	COG1454	alcohol dehydrogenase
A8F97_RS00130	COG3395	kinase activity
A8F97_RS00135	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
A8F97_RS00140	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A8F97_RS00145	COG0129	dihydroxy-acid dehydratase activity
A8F97_RS00150	COG2610	gluconate transmembrane transporter activity
A8F97_RS00155	COG1414	Transcriptional regulator
A8F97_RS00160	COG1349	DNA-binding transcription factor activity
A8F97_RS00215	COG1358	cellular component organization or biogenesis
A8F97_RS00230	COG4245	von Willebrand factor, type A
A8F97_RS00245	COG4245	von Willebrand factor, type A
A8F97_RS00260	COG0803	Belongs to the bacterial solute-binding protein 9 family
A8F97_RS00265	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A8F97_RS00270	COG1121	(ABC) transporter
A8F97_RS00285	COG2971	BadF BadG BcrA BcrD
A8F97_RS00305	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
A8F97_RS00310	COG3842	ATPase activity
A8F97_RS00315	COG1175	transmembrane transport
A8F97_RS00320	COG0395	ABC-type sugar transport system, permease component
A8F97_RS00340	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A8F97_RS00360	COG0629	single-stranded DNA binding
A8F97_RS00370	COG0432	Pfam Uncharacterised protein family UPF0047
A8F97_RS00375	COG1518	maintenance of DNA repeat elements
A8F97_RS00380	COG1203	CRISPR-associated helicase, Cas3
A8F97_RS00440	COG1451	nucleotide metabolic process
A8F97_RS00445	COG1448	Aminotransferase
A8F97_RS00455	COG1522	sequence-specific DNA binding
A8F97_RS00465	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A8F97_RS00480	COG2124	cytochrome p450
A8F97_RS00490	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A8F97_RS00510	COG0583	DNA-binding transcription factor activity
A8F97_RS00515	COG0583	DNA-binding transcription factor activity
A8F97_RS00525	COG2610	gluconate transmembrane transporter activity
A8F97_RS00530	COG1929	Belongs to the glycerate kinase type-1 family
A8F97_RS00540	COG3835	regulator
A8F97_RS00545	COG1609	Transcriptional regulator
A8F97_RS00555	COG0840	transmembrane signaling receptor activity
A8F97_RS00560	COG0318	PFAM AMP-dependent synthetase and ligase
A8F97_RS00560	COG0204	Acyl-transferase
A8F97_RS00565	COG0477	Major facilitator Superfamily
A8F97_RS00570	COG2153	protein acetylation
A8F97_RS00585	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A8F97_RS00590	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A8F97_RS00595	COG1872	DUF167
A8F97_RS00600	COG0762	integral membrane protein
A8F97_RS00605	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A8F97_RS00610	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A8F97_RS00615	COG2805	Type II/IV secretion system protein
A8F97_RS00625	COG0840	transmembrane signaling receptor activity
A8F97_RS00630	COG1959	2 iron, 2 sulfur cluster binding
A8F97_RS00635	COG0557	exoribonuclease II activity
A8F97_RS00640	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A8F97_RS00645	COG0840	transmembrane signaling receptor activity
A8F97_RS00650	COG3766	membrane
A8F97_RS00655	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A8F97_RS00660	COG1690	Belongs to the RtcB family
A8F97_RS00665	COG0840	transmembrane signaling receptor activity
A8F97_RS00670	COG1073	alpha beta
A8F97_RS00675	COG0360	Binds together with S18 to 16S ribosomal RNA
A8F97_RS00680	COG2965	DNA replication, synthesis of RNA primer
A8F97_RS00685	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A8F97_RS00690	COG0359	binds to the 23S rRNA
A8F97_RS00700	COG3061	Opacity-associated protein A
A8F97_RS00705	COG0545	Peptidyl-prolyl cis-trans isomerase
A8F97_RS00710	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
A8F97_RS00725	COG0737	Belongs to the 5'-nucleotidase family
A8F97_RS00730	COG1218	3'(2'),5'-bisphosphate nucleotidase
A8F97_RS00735	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
A8F97_RS00745	COG1253	flavin adenine dinucleotide binding
A8F97_RS00750	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A8F97_RS00755	COG0729	surface antigen
A8F97_RS00760	COG2911	Protein conserved in bacteria
A8F97_RS00765	COG2105	PFAM AIG2 family protein
A8F97_RS00770	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
A8F97_RS00775	COG0840	transmembrane signaling receptor activity
A8F97_RS00780	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
A8F97_RS00785	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A8F97_RS00790	COG1968	undecaprenyl-diphosphatase activity
A8F97_RS00795	COG0617	tRNA 3'-terminal CCA addition
A8F97_RS00800	COG4991	sh3 domain protein
A8F97_RS00805	COG3025	triphosphatase activity
A8F97_RS00810	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
A8F97_RS00815	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
A8F97_RS00815	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A8F97_RS00820	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A8F97_RS00825	COG3530	Putative quorum-sensing-regulated virulence factor
A8F97_RS00835	COG0840	transmembrane signaling receptor activity
A8F97_RS00840	COG2721	sulfolactate sulfo-lyase activity
A8F97_RS00845	COG2271	Major facilitator Superfamily
A8F97_RS00850	COG4948	Mandelate Racemase Muconate Lactonizing
A8F97_RS00855	COG4948	Mandelate Racemase Muconate Lactonizing
A8F97_RS00865	COG2084	Dehydrogenase
A8F97_RS00870	COG1929	Belongs to the glycerate kinase type-1 family
A8F97_RS00880	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A8F97_RS00885	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A8F97_RS00890	COG3956	TIGRFAM MazG family protein
A8F97_RS00895	COG0504	CTP synthase activity
A8F97_RS00900	COG0148	phosphopyruvate hydratase activity
A8F97_RS00910	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A8F97_RS00920	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
A8F97_RS00940	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A8F97_RS00945	COG0602	queuosine metabolic process
A8F97_RS00950	COG0720	synthase
A8F97_RS00965	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
A8F97_RS00970	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A8F97_RS00975	COG0175	sulfate reduction
A8F97_RS00980	COG1609	Transcriptional regulator
A8F97_RS00985	COG2723	6-phospho-beta-galactosidase activity
A8F97_RS00995	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A8F97_RS01000	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A8F97_RS01005	COG1648	precorrin-2 dehydrogenase activity
A8F97_RS01005	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A8F97_RS01010	COG0175	sulfate reduction
A8F97_RS01015	COG2895	sulfate adenylyltransferase (ATP) activity
A8F97_RS01030	COG1126	abc transporter atp-binding protein
A8F97_RS01035	COG0765	amino acid transport
A8F97_RS01045	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
A8F97_RS01050	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
A8F97_RS01055	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
A8F97_RS01060	COG0585	pseudouridine synthase activity
A8F97_RS01065	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A8F97_RS01070	COG4942	peptidase
A8F97_RS01070	COG1388	LysM domain
A8F97_RS01080	COG0442	prolyl-tRNA aminoacylation
A8F97_RS01085	COG1720	tRNA m6t6A37 methyltransferase activity
A8F97_RS01095	COG1464	Belongs to the NlpA lipoprotein family
A8F97_RS01100	COG2011	ABC-type metal ion transport system permease component
A8F97_RS01105	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A8F97_RS01110	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A8F97_RS01145	COG0477	Major facilitator Superfamily
A8F97_RS01150	COG5544	Lipoprotein
A8F97_RS01155	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A8F97_RS01160	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A8F97_RS01160	COG1042	CoA-binding domain protein
A8F97_RS01160	COG0045	succinate-CoA ligase (ADP-forming) activity
A8F97_RS01165	COG3148	PFAM DTW domain containing protein
A8F97_RS01170	COG3118	belongs to the thioredoxin family
A8F97_RS01175	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A8F97_RS01190	COG2814	Major facilitator Superfamily
A8F97_RS01195	COG1566	PFAM secretion protein HlyD family protein
A8F97_RS01200	COG1846	Transcriptional regulator
A8F97_RS01210	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
A8F97_RS01215	COG2814	Major facilitator Superfamily
A8F97_RS01220	COG2706	6-phosphogluconolactonase activity
A8F97_RS01230	COG0596	Alpha beta hydrolase
A8F97_RS01235	COG2113	Glycine betaine
A8F97_RS01240	COG4176	ABC-type proline glycine betaine transport system permease component
A8F97_RS01245	COG4175	Glycine betaine
A8F97_RS01290	COG0765	amino acid transport
A8F97_RS01300	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A8F97_RS01310	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A8F97_RS01315	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A8F97_RS01320	COG1882	Formate acetyltransferase
A8F97_RS01325	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A8F97_RS01335	COG0436	Aminotransferase
A8F97_RS01340	COG0235	Class ii aldolase
A8F97_RS01345	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
A8F97_RS01350	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
A8F97_RS01395	COG2963	transposase activity
A8F97_RS01405	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
A8F97_RS01410	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
A8F97_RS01420	COG1960	acyl-CoA dehydrogenase activity
A8F97_RS01425	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
A8F97_RS01430	COG0121	glutamine amidotransferase
A8F97_RS01435	COG3034	peptidoglycan biosynthetic process
A8F97_RS01440	COG2226	methyltransferase
A8F97_RS01450	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A8F97_RS01455	COG2195	Cleaves the N-terminal amino acid of tripeptides
A8F97_RS01460	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
A8F97_RS01465	COG1073	alpha beta
A8F97_RS01485	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A8F97_RS01490	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
A8F97_RS01505	COG0582	viral genome integration into host DNA
A8F97_RS01555	COG0582	viral genome integration into host DNA
A8F97_RS01565	COG1982	Orn Lys Arg decarboxylase major
A8F97_RS01570	COG1113	amino acid transport
A8F97_RS01585	COG5441	Belongs to the UPF0261 family
A8F97_RS01590	COG5564	TIM-barrel signal transduction protein
A8F97_RS01605	COG1917	Cupin 2, conserved barrel domain protein
A8F97_RS01605	COG2169	Transcriptional regulator
A8F97_RS01610	COG0741	lytic transglycosylase activity
A8F97_RS01615	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
A8F97_RS01620	COG1194	a g-specific adenine glycosylase
A8F97_RS01625	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A8F97_RS01630	COG3171	Protein conserved in bacteria
A8F97_RS01640	COG0667	Aldo Keto reductase
A8F97_RS01650	COG3066	DNA modification
A8F97_RS01655	COG0494	nUDIX hydrolase
A8F97_RS01665	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A8F97_RS01670	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
A8F97_RS01675	COG4969	Belongs to the N-Me-Phe pilin family
A8F97_RS01680	COG4795	General secretion pathway protein
A8F97_RS01695	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
A8F97_RS01700	COG1025	Belongs to the peptidase M16 family
A8F97_RS01705	COG1074	ATP-dependent DNA helicase activity
A8F97_RS01710	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A8F97_RS01715	COG1609	Transcriptional regulator
A8F97_RS01725	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
A8F97_RS01725	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A8F97_RS01730	COG0860	N-Acetylmuramoyl-L-alanine amidase
A8F97_RS01750	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
A8F97_RS01760	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A8F97_RS01765	COG2166	iron-sulfur cluster assembly
A8F97_RS01770	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A8F97_RS01780	COG0583	DNA-binding transcription factor activity
A8F97_RS01785	COG2363	Small membrane protein
A8F97_RS01790	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
A8F97_RS01795	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A8F97_RS01800	COG1611	Belongs to the LOG family
A8F97_RS01805	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
A8F97_RS01805	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
A8F97_RS01845	COG2171	N-acyltransferase activity
A8F97_RS01850	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
A8F97_RS01860	COG0052	Belongs to the universal ribosomal protein uS2 family
A8F97_RS01865	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A8F97_RS01870	COG0528	UMP kinase activity
A8F97_RS01875	COG0233	cytoplasmic translational termination
A8F97_RS01880	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
A8F97_RS01885	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A8F97_RS01890	COG0575	Belongs to the CDS family
A8F97_RS01895	COG0750	zinc metalloprotease
A8F97_RS01900	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A8F97_RS01905	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
A8F97_RS01910	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A8F97_RS01915	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A8F97_RS01920	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A8F97_RS01925	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A8F97_RS01930	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A8F97_RS01935	COG0587	DNA-directed DNA polymerase activity
A8F97_RS01940	COG0825	malonyl-CoA metabolic process
A8F97_RS01945	COG0346	lactoylglutathione lyase activity
A8F97_RS01950	COG0037	tRNA processing
A8F97_RS01955	COG4568	rho-dependent transcription termination
A8F97_RS01970	COG3015	lipoprotein NlpE involved in copper resistance
A8F97_RS01975	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A8F97_RS01980	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
A8F97_RS01990	COG4943	cyclic-guanylate-specific phosphodiesterase activity
A8F97_RS01995	COG2824	Alkylphosphonate utilization operon protein PhnA
A8F97_RS02000	COG2951	lytic endotransglycosylase activity
A8F97_RS02010	COG0583	DNA-binding transcription factor activity
A8F97_RS02040	COG2186	Transcriptional regulator
A8F97_RS02045	COG1312	Catalyzes the dehydration of D-mannonate
A8F97_RS02050	COG5297	Belongs to the glycosyl hydrolase family 6
A8F97_RS02055	COG5434	Belongs to the glycosyl hydrolase 28 family
A8F97_RS02065	COG1132	(ABC) transporter
A8F97_RS02080	COG4615	Cyclic peptide transporter
A8F97_RS02090	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A8F97_RS02095	COG3123	guanosine phosphorylase activity
A8F97_RS02100	COG2211	Major facilitator Superfamily
A8F97_RS02105	COG1397	ADP-ribosylglycohydrolase
A8F97_RS02110	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A8F97_RS02115	COG2188	Transcriptional regulator
A8F97_RS02125	COG2974	May be involved in recombination
A8F97_RS02130	COG1940	carbohydrate kinase activity
A8F97_RS02135	COG0419	ATPase involved in DNA repair
A8F97_RS02140	COG0420	3'-5' exonuclease activity
A8F97_RS02160	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A8F97_RS02175	COG0668	transmembrane transport
A8F97_RS02180	COG0450	alkyl hydroperoxide reductase
A8F97_RS02185	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
A8F97_RS02190	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A8F97_RS02195	COG0343	queuine tRNA-ribosyltransferase activity
A8F97_RS02200	COG1862	Preprotein translocase
A8F97_RS02210	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A8F97_RS02220	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A8F97_RS02225	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A8F97_RS02225	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A8F97_RS02230	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
A8F97_RS02235	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A8F97_RS02240	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
A8F97_RS02245	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A8F97_RS02250	COG0142	geranyltranstransferase activity
A8F97_RS02255	COG1722	exodeoxyribonuclease VII activity
A8F97_RS02260	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A8F97_RS02260	COG0301	tRNA thio-modification
A8F97_RS02265	COG0693	protein deglycase activity
A8F97_RS02270	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A8F97_RS02275	COG1666	GTP binding
A8F97_RS02280	COG2814	Major facilitator Superfamily
A8F97_RS02285	COG0109	protoheme IX farnesyltransferase activity
A8F97_RS02290	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
A8F97_RS02295	COG1845	cytochrome c oxidase, subunit III
A8F97_RS02300	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A8F97_RS02305	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A8F97_RS02310	COG2223	nitrite transmembrane transporter activity
A8F97_RS02315	COG3056	Lipoprotein
A8F97_RS02320	COG0271	Belongs to the BolA IbaG family
A8F97_RS02325	COG0544	peptidyl-prolyl cis-trans isomerase activity
A8F97_RS02330	COG0740	serine-type endopeptidase activity
A8F97_RS02335	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A8F97_RS02340	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A8F97_RS02345	COG0776	regulation of translation
A8F97_RS02350	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A8F97_RS02355	COG1555	photosystem II stabilization
A8F97_RS02360	COG0824	Thioesterase
A8F97_RS02365	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
A8F97_RS02370	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A8F97_RS02380	COG1522	sequence-specific DNA binding
A8F97_RS02385	COG1132	(ABC) transporter
A8F97_RS02390	COG1132	(ABC) transporter
A8F97_RS02395	COG0347	Belongs to the P(II) protein family
A8F97_RS02400	COG0004	ammonium transporteR
A8F97_RS02405	COG1946	Acyl-CoA thioesterase
A8F97_RS02410	COG3126	Type III secretion system lipoprotein chaperone (YscW)
A8F97_RS02415	COG3695	enzyme binding
A8F97_RS02435	COG0254	rRNA binding
A8F97_RS02440	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A8F97_RS02445	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A8F97_RS02450	COG1309	transcriptional regulator
A8F97_RS02465	COG2832	Protein of unknown function (DUF454)
A8F97_RS02470	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A8F97_RS02480	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A8F97_RS02485	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A8F97_RS02490	COG0326	Molecular chaperone. Has ATPase activity
A8F97_RS02495	COG0563	adenylate kinase activity
A8F97_RS02500	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
A8F97_RS02505	COG4651	solute:proton antiporter activity
A8F97_RS02505	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A8F97_RS02510	COG0737	Belongs to the 5'-nucleotidase family
A8F97_RS02520	COG1966	Carbon starvation protein
A8F97_RS02525	COG2879	small protein
A8F97_RS02530	COG0523	cobalamin synthesis protein
A8F97_RS02535	COG5434	Belongs to the glycosyl hydrolase 28 family
A8F97_RS02545	COG3735	TraB family
A8F97_RS02550	COG2217	Heavy metal translocating P-type atpase
A8F97_RS02565	COG1585	Membrane protein implicated in regulation of membrane protease activity
A8F97_RS02570	COG0330	HflC and HflK could
A8F97_RS02575	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A8F97_RS02585	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A8F97_RS02590	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A8F97_RS02600	COG0784	Response regulator, receiver
A8F97_RS02600	COG2205	protein histidine kinase activity
A8F97_RS02605	COG2197	response regulator
A8F97_RS02610	COG2198	Histidine kinase
A8F97_RS02610	COG0642	Histidine kinase
A8F97_RS02615	COG2223	nitrite transmembrane transporter activity
A8F97_RS02620	COG1733	regulation of RNA biosynthetic process
A8F97_RS02625	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
A8F97_RS02630	COG1169	isochorismate synthase
A8F97_RS02635	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
A8F97_RS02645	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
A8F97_RS02650	COG1441	menaquinone biosynthetic process
A8F97_RS02665	COG0814	amino acid
A8F97_RS02675	COG3118	belongs to the thioredoxin family
A8F97_RS02680	COG0300	oxidoreductase activity
A8F97_RS02685	COG2755	lipolytic protein G-D-S-L family
A8F97_RS02690	COG4181	ATPase activity
A8F97_RS02695	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
A8F97_RS02700	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A8F97_RS02710	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A8F97_RS02715	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A8F97_RS02720	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A8F97_RS02725	COG2233	PERMEase
A8F97_RS02730	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A8F97_RS02735	COG1393	Belongs to the ArsC family
A8F97_RS02740	COG4783	chaperone-mediated protein folding
A8F97_RS02745	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A8F97_RS02750	COG2716	regulation of RNA biosynthetic process
A8F97_RS02760	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
A8F97_RS02765	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A8F97_RS02770	COG2707	UPF0756 membrane protein
A8F97_RS02775	COG1444	tRNA N-acetyltransferase activity
A8F97_RS02785	COG0400	carboxylic ester hydrolase activity
A8F97_RS02795	COG0183	Belongs to the thiolase family
A8F97_RS02800	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
A8F97_RS02805	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
A8F97_RS02820	COG2851	Citrate transporter
A8F97_RS02825	COG0583	DNA-binding transcription factor activity
A8F97_RS02835	COG1876	peptidase activity
A8F97_RS02840	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A8F97_RS02845	COG1393	Belongs to the ArsC family
A8F97_RS02850	COG1794	racemase activity, acting on amino acids and derivatives
A8F97_RS02860	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A8F97_RS02865	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A8F97_RS02870	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A8F97_RS02875	COG0321	lipoyl(octanoyl) transferase activity
A8F97_RS02880	COG2921	Belongs to the UPF0250 family
A8F97_RS02885	COG1686	Belongs to the peptidase S11 family
A8F97_RS02890	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A8F97_RS02895	COG0772	Belongs to the SEDS family
A8F97_RS02900	COG0768	penicillin binding
A8F97_RS02905	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
A8F97_RS02910	COG0799	negative regulation of ribosome biogenesis
A8F97_RS02915	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A8F97_RS02920	COG1466	dna polymerase III delta subunit
A8F97_RS02925	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
A8F97_RS02930	COG0495	leucyl-tRNA aminoacylation
A8F97_RS02935	COG2888	peptidyl-tyrosine sulfation
A8F97_RS02940	COG1126	abc transporter atp-binding protein
A8F97_RS02945	COG0765	amino acid transport
A8F97_RS02950	COG0765	amino acid transport
A8F97_RS02960	COG0815	Transfers the fatty acyl group on membrane lipoproteins
A8F97_RS02965	COG4535	Mg2 and Co2 transporter CorC
A8F97_RS02970	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A8F97_RS02975	COG1702	phosphate starvation-inducible protein PhoH
A8F97_RS02980	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A8F97_RS02985	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A8F97_RS03025	COG0367	asparagine synthase
A8F97_RS03030	COG1846	Transcriptional regulator
A8F97_RS03030	COG1940	carbohydrate kinase activity
A8F97_RS03035	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A8F97_RS03040	COG0363	glucosamine-6-phosphate deaminase activity
A8F97_RS03045	COG2190	(PTS) system
A8F97_RS03045	COG1263	PTS System
A8F97_RS03045	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A8F97_RS03050	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A8F97_RS03055	COG0735	belongs to the Fur family
A8F97_RS03065	COG0840	transmembrane signaling receptor activity
A8F97_RS03075	COG0596	Alpha beta hydrolase
A8F97_RS03080	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
A8F97_RS03085	COG0033	Phosphoglucomutase
A8F97_RS03115	COG3272	Protein of unknown function (DUF1722)
A8F97_RS03120	COG0415	Belongs to the DNA photolyase family
A8F97_RS03125	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A8F97_RS03130	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
A8F97_RS03135	COG1984	allophanate hydrolase subunit 2
A8F97_RS03140	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
A8F97_RS03145	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
A8F97_RS03150	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A8F97_RS03165	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
A8F97_RS03170	COG1053	succinate dehydrogenase
A8F97_RS03175	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A8F97_RS03180	COG0567	Dehydrogenase, E1 component
A8F97_RS03185	COG0508	dehydrogenase complex catalyzes the overall conversion of
A8F97_RS03190	COG0045	succinate-CoA ligase (ADP-forming) activity
A8F97_RS03195	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A8F97_RS03205	COG1271	oxidase subunit
A8F97_RS03210	COG1294	oxidase, subunit
A8F97_RS03215	COG4890	Cyd operon protein YbgT
A8F97_RS03220	COG3790	cyd operon protein YbgE
A8F97_RS03225	COG0824	Thioesterase
A8F97_RS03230	COG0811	peptide transport
A8F97_RS03235	COG0848	biopolymer transport protein
A8F97_RS03240	COG3064	Membrane
A8F97_RS03245	COG0823	Involved in the tonB-independent uptake of proteins
A8F97_RS03250	COG2885	chlorophyll binding
A8F97_RS03255	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
A8F97_RS03275	COG1811	Na channel or pump
A8F97_RS03285	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
A8F97_RS03295	COG1230	cation diffusion facilitator family transporter
A8F97_RS03300	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A8F97_RS03310	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A8F97_RS03315	COG0583	DNA-binding transcription factor activity
A8F97_RS03320	COG0588	phosphoglycerate mutase activity
A8F97_RS03325	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A8F97_RS03330	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A8F97_RS03350	COG2017	converts alpha-aldose to the beta-anomer
A8F97_RS03355	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A8F97_RS03360	COG1119	ATPase activity
A8F97_RS03365	COG3585	molybdate ion transport
A8F97_RS03365	COG2005	Transcriptional regulator
A8F97_RS03375	COG0725	ABC transporter, periplasmic molybdate-binding protein
A8F97_RS03380	COG4149	molybdate abc transporter
A8F97_RS03385	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
A8F97_RS03400	COG0673	inositol 2-dehydrogenase activity
A8F97_RS03410	COG2211	Major facilitator Superfamily
A8F97_RS03415	COG0837	glucose binding
A8F97_RS03420	COG0561	phosphatase activity
A8F97_RS03435	COG2916	Histone family protein nucleoid-structuring protein H-NS
A8F97_RS03440	COG2706	6-phosphogluconolactonase activity
A8F97_RS03460	COG2864	formate dehydrogenase
A8F97_RS03465	COG0437	4 iron, 4 sulfur cluster binding
A8F97_RS03470	COG0243	molybdopterin cofactor binding
A8F97_RS03470	COG3383	formate dehydrogenase (NAD+) activity
A8F97_RS03475	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A8F97_RS03475	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A8F97_RS03480	COG0489	protein tyrosine kinase activity
A8F97_RS03485	COG0572	uridine kinase
A8F97_RS03490	COG0717	Belongs to the dCTP deaminase family
A8F97_RS03495	COG2982	Protein involved in outer membrane biogenesis
A8F97_RS03500	COG3069	C4-dicarboxylate transmembrane transporter activity
A8F97_RS03505	COG1253	flavin adenine dinucleotide binding
A8F97_RS03510	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A8F97_RS03525	COG0489	protein tyrosine kinase activity
A8F97_RS03525	COG3206	protein involved in exopolysaccharide biosynthesis
A8F97_RS03560	COG0438	transferase activity, transferring glycosyl groups
A8F97_RS03570	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A8F97_RS03590	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A8F97_RS03615	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A8F97_RS03620	COG1605	Chorismate mutase
A8F97_RS03635	COG3706	GGDEF domain
A8F97_RS03660	COG3962	Belongs to the TPP enzyme family
A8F97_RS03670	COG0673	inositol 2-dehydrogenase activity
A8F97_RS03685	COG1172	Belongs to the binding-protein-dependent transport system permease family
A8F97_RS03695	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A8F97_RS03705	COG3718	enzyme involved in inositol metabolism
A8F97_RS03720	COG3842	ATPase activity
A8F97_RS03725	COG4208	sulfate ABC transporter
A8F97_RS03730	COG1840	ABC-type Fe3 transport system, periplasmic component
A8F97_RS03740	COG3615	Tellurite resistance protein tehB
A8F97_RS03775	COG0401	homolog of Blt101
A8F97_RS03790	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A8F97_RS03795	COG0303	'Molybdopterin
A8F97_RS03800	COG4172	Belongs to the ABC transporter superfamily
A8F97_RS03805	COG0747	negative chemotaxis
A8F97_RS03810	COG0601	transmembrane transport
A8F97_RS03815	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A8F97_RS03820	COG0281	malic enzyme
A8F97_RS03825	COG0295	cytidine deaminase activity
A8F97_RS03835	COG1346	cytolysis
A8F97_RS03840	COG1380	Effector of murein hydrolase LrgA
A8F97_RS03845	COG5297	Belongs to the glycosyl hydrolase family 6
A8F97_RS03855	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A8F97_RS03860	COG0156	8-amino-7-oxononanoate synthase activity
A8F97_RS03865	COG2226	methyltransferase
A8F97_RS03870	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
A8F97_RS03880	COG0556	nucleotide-excision repair
A8F97_RS03900	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A8F97_RS03905	COG0521	Mo-molybdopterin cofactor biosynthetic process
A8F97_RS03910	COG0315	cyclic pyranopterin monophosphate synthase activity
A8F97_RS03915	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
A8F97_RS03920	COG0314	molybdopterin synthase activity
A8F97_RS03925	COG0670	Belongs to the BI1 family
A8F97_RS03930	COG0842	Transport permease protein
A8F97_RS03935	COG0842	Transport permease protein
A8F97_RS03940	COG1131	(ABC) transporter
A8F97_RS03955	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A8F97_RS03960	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A8F97_RS03965	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A8F97_RS03970	COG1120	ATPase activity
A8F97_RS03980	COG0513	Belongs to the DEAD box helicase family
A8F97_RS04000	COG2195	Cleaves the N-terminal amino acid of tripeptides
A8F97_RS04005	COG0747	negative chemotaxis
A8F97_RS04010	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A8F97_RS04015	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A8F97_RS04020	COG0833	amino acid
A8F97_RS04025	COG2040	homocysteine
A8F97_RS04045	COG1686	Belongs to the peptidase S11 family
A8F97_RS04055	COG1349	DNA-binding transcription factor activity
A8F97_RS04060	COG1177	transmembrane transport
A8F97_RS04065	COG3842	ATPase activity
A8F97_RS04075	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A8F97_RS04085	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
A8F97_RS04090	COG1280	lysine exporter protein (LysE YggA)
A8F97_RS04230	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A8F97_RS04235	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A8F97_RS04245	COG1126	abc transporter atp-binding protein
A8F97_RS04250	COG0765	amino acid transport
A8F97_RS04255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A8F97_RS04260	COG0783	Belongs to the Dps family
A8F97_RS04265	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A8F97_RS04265	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A8F97_RS04275	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
A8F97_RS04280	COG2807	transmembrane transport
A8F97_RS04285	COG0534	Mate efflux family protein
A8F97_RS04290	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A8F97_RS04310	COG3122	Protein conserved in bacteria
A8F97_RS04335	COG2979	Protein of unknown function (DUF533)
A8F97_RS04340	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A8F97_RS04345	COG1067	ATP-dependent peptidase activity
A8F97_RS04360	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
A8F97_RS04365	COG3070	regulator of competence-specific genes
A8F97_RS04370	COG1289	transmembrane transporter activity
A8F97_RS04375	COG3304	Inner membrane component domain
A8F97_RS04380	COG0210	DNA helicase
A8F97_RS04385	COG1803	Methylglyoxal synthase
A8F97_RS04395	COG1832	CoA-binding protein
A8F97_RS04400	COG3785	DNA binding
A8F97_RS04405	COG1254	Belongs to the acylphosphatase family
A8F97_RS04410	COG2920	part of a sulfur-relay system
A8F97_RS04415	COG0670	Belongs to the BI1 family
A8F97_RS04475	COG0589	response to stress
A8F97_RS04480	COG1683	Conserved Protein
A8F97_RS04495	COG0840	transmembrane signaling receptor activity
A8F97_RS04505	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
A8F97_RS04510	COG2943	transferase activity, transferring hexosyl groups
A8F97_RS04515	COG1560	Kdo2-lipid A biosynthetic process
A8F97_RS04520	COG1902	pentaerythritol trinitrate reductase activity
A8F97_RS04525	COG1054	Belongs to the UPF0176 family
A8F97_RS04530	COG2353	YceI-like domain
A8F97_RS04535	COG3038	cytochrome b561
A8F97_RS04555	COG0418	dihydroorotase activity
A8F97_RS04565	COG1530	ribonuclease E activity
A8F97_RS04565	COG1530	ribonuclease E activity
A8F97_RS04570	COG0564	pseudouridine synthase activity
A8F97_RS04575	COG0424	maF-like protein
A8F97_RS04580	COG1399	metal-binding, possibly nucleic acid-binding protein
A8F97_RS04585	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A8F97_RS04590	COG0416	fatty acid biosynthetic process
A8F97_RS04595	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A8F97_RS04600	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A8F97_RS04610	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A8F97_RS04615	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A8F97_RS04620	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A8F97_RS04625	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A8F97_RS04630	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A8F97_RS04635	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A8F97_RS04640	COG0470	DNA polymerase III
A8F97_RS04645	COG0084	hydrolase, TatD family'
A8F97_RS04650	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A8F97_RS04650	COG1263	PTS System
A8F97_RS04655	COG0537	adenosine 5'-monophosphoramidase activity
A8F97_RS04665	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
A8F97_RS04675	COG1472	Belongs to the glycosyl hydrolase 3 family
A8F97_RS04680	COG3150	esterase
A8F97_RS04685	COG1252	NADH dehydrogenase
A8F97_RS04690	COG3134	Outer membrane lipoprotein
A8F97_RS04695	COG2814	Major facilitator Superfamily
A8F97_RS04705	COG1309	transcriptional regulator
A8F97_RS04710	COG0443	Heat shock 70 kDa protein
A8F97_RS04715	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A8F97_RS04720	COG4591	ABC-type transport system involved in lipoprotein release permease component
A8F97_RS04725	COG1136	(ABC) transporter
A8F97_RS04730	COG4591	ABC-type transport system involved in lipoprotein release permease component
A8F97_RS04735	COG1940	carbohydrate kinase activity
A8F97_RS04755	COG2226	methyltransferase
A8F97_RS04760	COG4139	cobalamin transport
A8F97_RS04765	COG0386	Belongs to the glutathione peroxidase family
A8F97_RS04770	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
A8F97_RS04775	COG0791	NLP P60 protein
A8F97_RS04780	COG0129	dihydroxy-acid dehydratase activity
A8F97_RS04785	COG1609	Transcriptional regulator
A8F97_RS04790	COG3265	gluconokinase activity
A8F97_RS04795	COG2610	gluconate transmembrane transporter activity
A8F97_RS04805	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
A8F97_RS04810	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
A8F97_RS04815	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A8F97_RS04820	COG4558	Periplasmic binding protein
A8F97_RS04825	COG3720	iron ion transport
A8F97_RS04830	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A8F97_RS04835	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
A8F97_RS04840	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A8F97_RS04840	COG0574	Belongs to the PEP-utilizing enzyme family
A8F97_RS04845	COG1477	protein flavinylation
A8F97_RS04855	COG0628	permease
A8F97_RS04860	COG0247	lactate metabolic process
A8F97_RS04860	COG0277	FAD linked oxidase domain protein
A8F97_RS04865	COG2050	protein possibly involved in aromatic compounds catabolism
A8F97_RS04875	COG0316	Belongs to the HesB IscA family
A8F97_RS04880	COG0719	Fe-S assembly protein
A8F97_RS04885	COG0396	ATPase activity
A8F97_RS04890	COG0719	Fe-S assembly protein
A8F97_RS04895	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A8F97_RS04900	COG2166	iron-sulfur cluster assembly
A8F97_RS04905	COG1388	LysM domain
A8F97_RS04905	COG1376	ErfK ybiS ycfS ynhG family protein
A8F97_RS04910	COG4238	major outer membrane lipoprotein
A8F97_RS04945	COG2382	esterase
A8F97_RS04960	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
A8F97_RS04965	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
A8F97_RS04970	COG0437	4 iron, 4 sulfur cluster binding
A8F97_RS04975	COG3301	Polysulphide reductase, NrfD
A8F97_RS04980	COG1138	Cytochrome C-type biogenesis protein
A8F97_RS04985	COG3088	subunit of a heme lyase
A8F97_RS04990	COG4235	cytochrome complex assembly
A8F97_RS04995	COG4133	protoheme IX ABC transporter activity
A8F97_RS05000	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A8F97_RS05005	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A8F97_RS05010	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A8F97_RS05015	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
A8F97_RS05020	COG1138	Cytochrome C-type biogenesis protein
A8F97_RS05025	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A8F97_RS05030	COG4235	cytochrome complex assembly
A8F97_RS05030	COG3088	subunit of a heme lyase
A8F97_RS05035	COG4235	cytochrome complex assembly
A8F97_RS05035	COG3088	subunit of a heme lyase
A8F97_RS05040	COG3005	denitrification pathway
A8F97_RS05045	COG3043	anaerobic respiration
A8F97_RS05050	COG0348	domain, Protein
A8F97_RS05055	COG0437	4 iron, 4 sulfur cluster binding
A8F97_RS05060	COG0243	molybdopterin cofactor binding
A8F97_RS05065	COG3062	negative regulation of establishment of protein localization
A8F97_RS05070	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A8F97_RS05075	COG3850	Histidine kinase
A8F97_RS05080	COG2197	response regulator
A8F97_RS05115	COG1704	LemA family
A8F97_RS05130	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A8F97_RS05155	COG3501	Rhs element vgr protein
A8F97_RS05165	COG3209	COG3209 Rhs family protein
A8F97_RS05165	COG4104	PAAR repeat-containing protein
A8F97_RS05190	COG3829	transcription factor binding
A8F97_RS05210	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
A8F97_RS05235	COG3842	ATPase activity
A8F97_RS05240	COG3665	Urea carboxylase-associated protein
A8F97_RS05255	COG3711	transcriptional antiterminator
A8F97_RS05260	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A8F97_RS05260	COG2190	(PTS) system
A8F97_RS05260	COG1263	PTS System
A8F97_RS05265	COG2723	6-phospho-beta-galactosidase activity
A8F97_RS05275	COG0583	DNA-binding transcription factor activity
A8F97_RS05280	COG1942	4-Oxalocrotonate Tautomerase
A8F97_RS05285	COG1794	racemase activity, acting on amino acids and derivatives
A8F97_RS05290	COG1556	Lactate utilization protein
A8F97_RS05295	COG1139	Iron-sulfur cluster binding protein
A8F97_RS05300	COG0247	lactate metabolic process
A8F97_RS05305	COG1620	l-lactate permease
A8F97_RS05320	COG0534	Mate efflux family protein
A8F97_RS05325	COG0307	riboflavin synthase, alpha
A8F97_RS05330	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A8F97_RS05335	COG1609	Transcriptional regulator
A8F97_RS05340	COG0791	NLP P60 protein
A8F97_RS05345	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
A8F97_RS05350	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A8F97_RS05355	COG0346	lactoylglutathione lyase activity
A8F97_RS05360	COG1846	Transcriptional regulator
A8F97_RS05370	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
A8F97_RS05375	COG3895	Periplasmic Protein
A8F97_RS05380	COG0259	pyridoxamine-phosphate oxidase activity
A8F97_RS05385	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A8F97_RS05390	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
A8F97_RS05395	COG0625	glutathione transferase activity
A8F97_RS05400	COG1301	dicarboxylic acid transport
A8F97_RS05405	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A8F97_RS05420	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A8F97_RS05425	COG0671	phosphoesterase, PA-phosphatase related
A8F97_RS05430	COG1879	ABC-type sugar transport system periplasmic component
A8F97_RS05440	COG1129	ABC transporter
A8F97_RS05445	COG1172	Belongs to the binding-protein-dependent transport system permease family
A8F97_RS05450	COG3959	Transketolase, thiamine diphosphate binding domain
A8F97_RS05455	COG3958	Transketolase
A8F97_RS05460	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A8F97_RS05465	COG1082	Xylose isomerase domain protein TIM barrel
A8F97_RS05475	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
A8F97_RS05480	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
A8F97_RS05485	COG0284	orotidine-5'-phosphate decarboxylase activity
A8F97_RS05490	COG0023	Translation Initiation Factor
A8F97_RS05500	COG0235	Class ii aldolase
A8F97_RS05520	COG1966	Carbon starvation protein
A8F97_RS05525	COG4989	oxidoreductase activity
A8F97_RS05530	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
A8F97_RS05535	COG0243	molybdopterin cofactor binding
A8F97_RS05540	COG0583	DNA-binding transcription factor activity
A8F97_RS05545	COG1609	Transcriptional regulator
A8F97_RS05550	COG2271	Major facilitator Superfamily
A8F97_RS05560	COG1053	succinate dehydrogenase
A8F97_RS05605	COG4171	peptide transport system, permease
A8F97_RS05615	COG4166	transmembrane transport
A8F97_RS05620	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
A8F97_RS05625	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
A8F97_RS05630	COG1842	Phage shock protein A
A8F97_RS05640	COG1983	PspC domain protein
A8F97_RS05645	COG3106	COG3106 Predicted ATPase
A8F97_RS05650	COG3768	UPF0283 membrane protein
A8F97_RS05670	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
A8F97_RS05675	COG2866	Carboxypeptidase
A8F97_RS05680	COG4166	transmembrane transport
A8F97_RS05685	COG0598	Magnesium transport protein CorA
A8F97_RS05695	COG0037	tRNA processing
A8F97_RS05700	COG0582	viral genome integration into host DNA
A8F97_RS05715	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A8F97_RS05720	COG0840	transmembrane signaling receptor activity
A8F97_RS05725	COG2911	Protein conserved in bacteria
A8F97_RS05735	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A8F97_RS05740	COG1643	Atp-dependent helicase
A8F97_RS05745	COG5001	Diguanylate cyclase
A8F97_RS05745	COG3300	MHYT domain
A8F97_RS05750	COG3591	Belongs to the peptidase S1B family
A8F97_RS05760	COG2205	protein histidine kinase activity
A8F97_RS05765	COG0745	RESPONSE REGULATOR receiver
A8F97_RS05775	COG4943	cyclic-guanylate-specific phosphodiesterase activity
A8F97_RS05785	COG0659	secondary active sulfate transmembrane transporter activity
A8F97_RS05790	COG0387	Pfam Sodium calcium exchanger
A8F97_RS05800	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
A8F97_RS05815	COG2197	response regulator
A8F97_RS05820	COG3850	Histidine kinase
A8F97_RS05825	COG2223	nitrite transmembrane transporter activity
A8F97_RS05830	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
A8F97_RS05835	COG1140	nitrate reductase beta subunit
A8F97_RS05840	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
A8F97_RS05845	COG2181	nitrate reductase activity
A8F97_RS05850	COG0697	spore germination
A8F97_RS05855	COG1846	Transcriptional regulator
A8F97_RS05865	COG2423	ornithine cyclodeaminase activity
A8F97_RS05880	COG2261	transglycosylase associated protein
A8F97_RS05910	COG1280	lysine exporter protein (LysE YggA)
A8F97_RS05915	COG3842	ATPase activity
A8F97_RS05925	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A8F97_RS05930	COG1012	belongs to the aldehyde dehydrogenase family
A8F97_RS05940	COG1176	ABC-type spermidine putrescine transport system, permease component I
A8F97_RS05950	COG1028	Short-chain dehydrogenase reductase Sdr
A8F97_RS05960	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A8F97_RS05970	COG0671	phosphoesterase, PA-phosphatase related
A8F97_RS05980	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A8F97_RS05985	COG2011	ABC-type metal ion transport system permease component
A8F97_RS05990	COG4948	Mandelate Racemase Muconate Lactonizing
A8F97_RS05995	COG1464	Belongs to the NlpA lipoprotein family
A8F97_RS06010	COG0583	DNA-binding transcription factor activity
A8F97_RS06015	COG4943	cyclic-guanylate-specific phosphodiesterase activity
A8F97_RS06025	COG1802	Transcriptional regulator
A8F97_RS06055	COG3210	domain, Protein
A8F97_RS06130	COG2211	Major facilitator Superfamily
A8F97_RS06135	COG3507	Belongs to the glycosyl hydrolase 43 family
A8F97_RS06155	COG0683	leucine binding
A8F97_RS06170	COG1129	ABC transporter
A8F97_RS06180	COG2314	TM2 domain
A8F97_RS06185	COG1126	abc transporter atp-binding protein
A8F97_RS06190	COG0765	amino acid transport
A8F97_RS06200	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A8F97_RS06205	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
A8F97_RS06210	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A8F97_RS06220	COG1473	amidohydrolase
A8F97_RS06225	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A8F97_RS06235	COG1609	Transcriptional regulator
A8F97_RS06240	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A8F97_RS06240	COG1263	PTS System
A8F97_RS06245	COG2723	6-phospho-beta-galactosidase activity
A8F97_RS06250	COG0483	inositol monophosphate 1-phosphatase activity
A8F97_RS06255	COG0346	lactoylglutathione lyase activity
A8F97_RS06295	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A8F97_RS06415	COG0515	serine threonine protein kinase
A8F97_RS06570	COG0012	GTP binding
A8F97_RS06575	COG0193	aminoacyl-tRNA hydrolase activity
A8F97_RS06585	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A8F97_RS06590	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
A8F97_RS06595	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
A8F97_RS06600	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
A8F97_RS06605	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A8F97_RS06610	COG2890	protein-(glutamine-N5) methyltransferase activity
A8F97_RS06620	COG2912	Transglutaminase-like superfamily
A8F97_RS06625	COG2877	3-deoxy-8-phosphooctulonate synthase activity
A8F97_RS06635	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
A8F97_RS06640	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
A8F97_RS06650	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A8F97_RS06655	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A8F97_RS06660	COG0673	inositol 2-dehydrogenase activity
A8F97_RS06675	COG0191	fructose-bisphosphate aldolase activity
A8F97_RS06680	COG2222	sugar isomerase
A8F97_RS06685	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A8F97_RS06690	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
A8F97_RS06695	COG3716	PTS system mannose fructose sorbose family IID component
A8F97_RS06705	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A8F97_RS06715	COG1349	DNA-binding transcription factor activity
A8F97_RS06740	COG4305	rare lipoprotein A
A8F97_RS06745	COG0604	alcohol dehydrogenase
A8F97_RS06750	COG0583	DNA-binding transcription factor activity
A8F97_RS06765	COG0738	Major facilitator superfamily
A8F97_RS06770	COG0456	acetyltransferase
A8F97_RS06790	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A8F97_RS06800	COG1028	Short-chain dehydrogenase reductase Sdr
A8F97_RS06810	COG1028	Short-chain dehydrogenase reductase Sdr
A8F97_RS06830	COG0671	phosphoesterase, PA-phosphatase related
A8F97_RS06830	COG2453	phosphatase
A8F97_RS06835	COG2267	carboxylic ester hydrolase activity
A8F97_RS06840	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A8F97_RS06850	COG4628	conserved protein (DUF2132)
A8F97_RS06855	COG1649	PFAM Uncharacterised BCR, COG1649
A8F97_RS06860	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A8F97_RS06865	COG0076	glutamate decarboxylase activity
A8F97_RS06870	COG1942	4-Oxalocrotonate Tautomerase
A8F97_RS06875	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A8F97_RS06880	COG4221	oxidoreductase activity
A8F97_RS06900	COG0477	Major facilitator Superfamily
A8F97_RS06910	COG1940	carbohydrate kinase activity
A8F97_RS06915	COG0583	DNA-binding transcription factor activity
A8F97_RS06920	COG2814	Major facilitator Superfamily
A8F97_RS06930	COG0114	fumarate hydratase activity
A8F97_RS06935	COG1482	cell wall glycoprotein biosynthetic process
A8F97_RS06940	COG5339	Protein conserved in bacteria
A8F97_RS06950	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A8F97_RS06965	COG0385	Bile acid
A8F97_RS06970	COG0673	inositol 2-dehydrogenase activity
A8F97_RS06980	COG1172	Belongs to the binding-protein-dependent transport system permease family
A8F97_RS06985	COG1129	ABC transporter
A8F97_RS06990	COG1879	ABC-type sugar transport system periplasmic component
A8F97_RS06995	COG1069	ribulokinase activity
A8F97_RS07000	COG2160	L-arabinose isomerase activity
A8F97_RS07010	COG4657	Part of a membrane complex involved in electron transport
A8F97_RS07015	COG2878	Part of a membrane complex involved in electron transport
A8F97_RS07020	COG4656	Part of a membrane complex involved in electron transport
A8F97_RS07025	COG4658	electron transport chain
A8F97_RS07030	COG4659	FMN binding
A8F97_RS07040	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A8F97_RS07045	COG3104	oligopeptide transport
A8F97_RS07065	COG0616	signal peptide processing
A8F97_RS07070	COG1028	Short-chain dehydrogenase reductase Sdr
A8F97_RS07075	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
A8F97_RS07080	COG1187	pseudouridine synthase activity
A8F97_RS07085	COG0009	L-threonylcarbamoyladenylate synthase
A8F97_RS07090	COG0613	PHP domain protein
A8F97_RS07095	COG1215	transferase activity, transferring glycosyl groups
A8F97_RS07110	COG0512	Glutamine amidotransferase of anthranilate synthase
A8F97_RS07115	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A8F97_RS07120	COG0135	phosphoribosylanthranilate isomerase activity
A8F97_RS07120	COG0134	indole-3-glycerol-phosphate synthase activity
A8F97_RS07125	COG0133	tryptophan synthase activity
A8F97_RS07130	COG0159	tryptophan synthase activity
A8F97_RS07135	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
A8F97_RS07140	COG3047	cAMP biosynthetic process
A8F97_RS07150	COG2917	probably involved in intracellular septation
A8F97_RS07155	COG1607	acyl-coa hydrolase
A8F97_RS07165	COG2350	Protein conserved in bacteria
A8F97_RS07175	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A8F97_RS07180	COG3099	Belongs to the UPF0263 family
A8F97_RS07190	COG0444	Belongs to the ABC transporter superfamily
A8F97_RS07195	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A8F97_RS07200	COG0601	transmembrane transport
A8F97_RS07215	COG1454	alcohol dehydrogenase
A8F97_RS07215	COG1012	belongs to the aldehyde dehydrogenase family
A8F97_RS07220	COG1435	thymidine kinase activity
A8F97_RS07230	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A8F97_RS07235	COG0745	RESPONSE REGULATOR receiver
A8F97_RS07240	COG1752	Esterase of the alpha-beta hydrolase superfamily
A8F97_RS07245	COG0788	formyltetrahydrofolate deformylase activity
A8F97_RS07280	COG2860	membrane
A8F97_RS07285	COG0708	Exodeoxyribonuclease III
A8F97_RS07295	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A8F97_RS07300	COG0778	Nitroreductase
A8F97_RS07305	COG0616	signal peptide processing
A8F97_RS07310	COG0252	asparaginase activity
A8F97_RS07315	COG1335	isochorismatase
A8F97_RS07320	COG3139	Protein of unknown function (DUF1315)
A8F97_RS07325	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A8F97_RS07330	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A8F97_RS07340	COG0656	L-ascorbic acid biosynthetic process
A8F97_RS07345	COG3713	MltA-interacting MipA family protein
A8F97_RS07350	COG2766	serine protein kinase
A8F97_RS07355	COG2718	Belongs to the UPF0229 family
A8F97_RS07370	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A8F97_RS07375	COG0205	6-phosphofructokinase activity
A8F97_RS07395	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A8F97_RS07405	COG3684	Belongs to the aldolase LacD family
A8F97_RS07410	COG2719	SpoVR family
A8F97_RS07415	COG2186	Transcriptional regulator
A8F97_RS07420	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A8F97_RS07425	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
A8F97_RS07435	COG2983	Belongs to the UPF0260 family
A8F97_RS07440	COG0179	Fumarylacetoacetate (FAA) hydrolase
A8F97_RS07445	COG3100	YcgL domain-containing protein
A8F97_RS07450	COG0850	regulation of cytokinetic process
A8F97_RS07455	COG2894	cell division
A8F97_RS07460	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
A8F97_RS07470	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
A8F97_RS07475	COG0318	PFAM AMP-dependent synthetase and ligase
A8F97_RS07480	COG3065	identical protein binding
A8F97_RS07490	COG1199	ATP-dependent helicase activity
A8F97_RS07495	COG0251	oxidation-reduction process
A8F97_RS07500	COG3140	Belongs to the UPF0181 family
A8F97_RS07510	COG0494	nUDIX hydrolase
A8F97_RS07515	COG1760	l-serine dehydratase
A8F97_RS07520	COG1253	flavin adenine dinucleotide binding
A8F97_RS07525	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
A8F97_RS07525	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A8F97_RS07530	COG3715	PTS system
A8F97_RS07535	COG3716	PTS system mannose fructose sorbose family IID component
A8F97_RS07540	COG4811	Protein of unknown function (DUF986)
A8F97_RS07545	COG1971	Probably functions as a manganese efflux pump
A8F97_RS07550	COG2226	methyltransferase
A8F97_RS07560	COG0803	Belongs to the bacterial solute-binding protein 9 family
A8F97_RS07565	COG1121	(ABC) transporter
A8F97_RS07570	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A8F97_RS07575	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A8F97_RS07580	COG3001	Fructosamine kinase
A8F97_RS07590	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A8F97_RS07595	COG1917	Cupin 2, conserved barrel domain protein
A8F97_RS07600	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
A8F97_RS07605	COG1028	Short-chain dehydrogenase reductase Sdr
A8F97_RS07615	COG1175	transmembrane transport
A8F97_RS07620	COG0395	ABC-type sugar transport system, permease component
A8F97_RS07625	COG3842	ATPase activity
A8F97_RS07630	COG1653	transport
A8F97_RS07635	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
A8F97_RS07640	COG2755	lipolytic protein G-D-S-L family
A8F97_RS07640	COG0657	acetylesterase activity
A8F97_RS07645	COG1988	membrane-bound metal-dependent
A8F97_RS07650	COG1823	symporter activity
A8F97_RS07655	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A8F97_RS07660	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A8F97_RS07670	COG1132	(ABC) transporter
A8F97_RS07685	COG0776	regulation of translation
A8F97_RS07690	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A8F97_RS07690	COG0072	phenylalanine-tRNA ligase activity
A8F97_RS07695	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A8F97_RS07700	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A8F97_RS07705	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A8F97_RS07710	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A8F97_RS07715	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A8F97_RS07720	COG1113	amino acid transport
A8F97_RS07735	COG0823	Involved in the tonB-independent uptake of proteins
A8F97_RS07740	COG0501	Belongs to the peptidase M48B family
A8F97_RS07750	COG1653	transport
A8F97_RS07755	COG2223	nitrite transmembrane transporter activity
A8F97_RS07760	COG3279	Response regulator of the LytR AlgR family
A8F97_RS07765	COG3275	phosphorelay sensor kinase activity
A8F97_RS07795	COG0348	domain, Protein
A8F97_RS07800	COG0538	isocitrate dehydrogenase activity
A8F97_RS07985	COG4725	Belongs to the MT-A70-like family
A8F97_RS07990	COG2974	May be involved in recombination
A8F97_RS08000	COG1802	Transcriptional regulator
A8F97_RS08000	COG4626	Terminase
A8F97_RS08095	COG0582	viral genome integration into host DNA
A8F97_RS08100	COG0538	isocitrate dehydrogenase activity
A8F97_RS08105	COG1187	pseudouridine synthase activity
A8F97_RS08115	COG0482	sulfurtransferase activity
A8F97_RS08120	COG2915	High frequency lysogenization protein hflD homolog
A8F97_RS08125	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A8F97_RS08140	COG2850	peptidyl-arginine hydroxylation
A8F97_RS08145	COG2195	Cleaves the N-terminal amino acid of tripeptides
A8F97_RS08150	COG3842	ATPase activity
A8F97_RS08160	COG1177	transmembrane transport
A8F97_RS08175	COG2207	Transcriptional regulator
A8F97_RS08185	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
A8F97_RS08190	COG1956	GAF domain-containing protein
A8F97_RS08195	COG2995	paraquat-inducible protein a
A8F97_RS08200	COG3008	intermembrane lipid transfer
A8F97_RS08205	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
A8F97_RS08205	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A8F97_RS08220	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
A8F97_RS08235	COG1278	Cold shock
A8F97_RS08270	COG1528	Iron-storage protein
A8F97_RS08280	COG1770	oligopeptidase
A8F97_RS08285	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
A8F97_RS08290	COG0800	Aldolase
A8F97_RS08295	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A8F97_RS08300	COG1737	Transcriptional regulator
A8F97_RS08305	COG0469	pyruvate kinase activity
A8F97_RS08310	COG1560	Kdo2-lipid A biosynthetic process
A8F97_RS08315	COG0739	heme binding
A8F97_RS08320	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
A8F97_RS08325	COG1121	(ABC) transporter
A8F97_RS08330	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A8F97_RS08340	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A8F97_RS08345	COG1447	Phosphotransferase system cellobiose-specific component IIA
A8F97_RS08350	COG4580	involved in the transport of maltose and maltodextrins
A8F97_RS08355	COG2255	four-way junction helicase activity
A8F97_RS08360	COG0632	four-way junction helicase activity
A8F97_RS08365	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
A8F97_RS08370	COG0217	transcriptional regulatory protein
A8F97_RS08375	COG0494	nUDIX hydrolase
A8F97_RS08380	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A8F97_RS08390	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
A8F97_RS08395	COG1801	Protein of unknown function DUF72
A8F97_RS08400	COG3788	relative of glutathione S-transferase, MAPEG superfamily
A8F97_RS08405	COG2226	methyltransferase
A8F97_RS08410	COG0500	methyltransferase
A8F97_RS08435	COG3142	Participates in the control of copper homeostasis
A8F97_RS08440	COG3102	Protein conserved in bacteria
A8F97_RS08445	COG0018	arginyl-trna synthetase
A8F97_RS08450	COG0728	peptidoglycan biosynthetic process
A8F97_RS08460	COG3132	Protein of unknown function, DUF480
A8F97_RS08465	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A8F97_RS08470	COG0477	Major facilitator Superfamily
A8F97_RS08475	COG2999	glutathione oxidoreductase activity
A8F97_RS08485	COG3381	protein complex oligomerization
A8F97_RS08490	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
A8F97_RS08515	COG1028	Short-chain dehydrogenase reductase Sdr
A8F97_RS08525	COG0840	transmembrane signaling receptor activity
A8F97_RS08530	COG3009	Protein conserved in bacteria
A8F97_RS08535	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A8F97_RS08535	COG3008	intermembrane lipid transfer
A8F97_RS08540	COG2995	paraquat-inducible protein a
A8F97_RS08545	COG0488	(ABC) transporter
A8F97_RS08550	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A8F97_RS08550	COG0116	Belongs to the methyltransferase superfamily
A8F97_RS08555	COG3217	Mosc domain protein beta barrel domain protein
A8F97_RS08555	COG0633	Ferredoxin
A8F97_RS08565	COG0167	dihydroorotate dehydrogenase activity
A8F97_RS08570	COG0308	aminopeptidase N
A8F97_RS08575	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
A8F97_RS08580	COG0017	Asparaginyl-tRNA synthetase
A8F97_RS08590	COG1448	Aminotransferase
A8F97_RS08595	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A8F97_RS08600	COG3108	Peptidase M15
A8F97_RS08605	COG2989	Protein conserved in bacteria
A8F97_RS08610	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
A8F97_RS08615	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
A8F97_RS08620	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
A8F97_RS08625	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A8F97_RS08630	COG1434	Gram-negative-bacterium-type cell wall biogenesis
A8F97_RS08635	COG3173	Aminoglycoside phosphotransferase
A8F97_RS08640	COG4733	cellulase activity
A8F97_RS08645	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
A8F97_RS08650	COG2835	tetraacyldisaccharide 4'-kinase activity
A8F97_RS08655	COG1663	tetraacyldisaccharide 4'-kinase activity
A8F97_RS08660	COG1132	(ABC) transporter
A8F97_RS08665	COG2333	competence protein COMEC
A8F97_RS08665	COG0658	competence protein
A8F97_RS08670	COG2926	Belongs to the UPF0265 family
A8F97_RS08675	COG4604	ABC transporter, ATP-binding protein
A8F97_RS08680	COG4605	iron ion homeostasis
A8F97_RS08690	COG4607	ABC-type enterochelin transport system periplasmic component
A8F97_RS08695	COG2925	Exonuclease
A8F97_RS08700	COG0531	amino acid
A8F97_RS08710	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
A8F97_RS08715	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
A8F97_RS08735	COG3052	prosthetic group binding
A8F97_RS08740	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
A8F97_RS08745	COG0179	Fumarylacetoacetate (FAA) hydrolase
A8F97_RS08750	COG3493	citrate carrier protein
A8F97_RS08760	COG4565	transcriptional regulatory protein
A8F97_RS08765	COG0840	transmembrane signaling receptor activity
A8F97_RS08770	COG0840	transmembrane signaling receptor activity
A8F97_RS08790	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A8F97_RS08795	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A8F97_RS08800	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A8F97_RS08805	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A8F97_RS08810	COG0131	Imidazoleglycerol-phosphate dehydratase
A8F97_RS08810	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A8F97_RS08815	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A8F97_RS08820	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
A8F97_RS08825	COG0107	imidazoleglycerol-phosphate synthase activity
A8F97_RS08830	COG0140	phosphoribosyl-ATP diphosphatase activity
A8F97_RS08830	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A8F97_RS08835	COG0776	regulation of translation
A8F97_RS08840	COG0539	negative regulation of cytoplasmic translation
A8F97_RS08845	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A8F97_RS08850	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A8F97_RS08855	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
A8F97_RS08860	COG1944	ATP diphosphatase activity
A8F97_RS08865	COG2116	formate transmembrane transporter activity
A8F97_RS08870	COG1882	Formate acetyltransferase
A8F97_RS08875	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A8F97_RS08900	COG0477	Major facilitator Superfamily
A8F97_RS08905	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A8F97_RS08910	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A8F97_RS08915	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
A8F97_RS08920	COG1674	ftsk spoiiie
A8F97_RS08920	COG3107	peptidoglycan biosynthetic process
A8F97_RS08930	COG0492	ferredoxin-NADP+ reductase activity
A8F97_RS08935	COG4988	ABC transporter
A8F97_RS08940	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
A8F97_RS08945	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
A8F97_RS08950	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A8F97_RS08965	COG0542	response to heat
A8F97_RS08970	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
A8F97_RS08975	COG1278	Cold shock
A8F97_RS08980	COG3593	DNA synthesis involved in DNA repair
A8F97_RS08985	COG2431	L-lysine efflux transmembrane transporter activity
A8F97_RS08990	COG1151	hydroxylamine reductase activity
A8F97_RS08995	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A8F97_RS09000	COG0702	epimerase
A8F97_RS09005	COG3023	N-Acetylmuramoyl-L-alanine amidase
A8F97_RS09010	COG0393	Putative heavy-metal-binding
A8F97_RS09015	COG1126	abc transporter atp-binding protein
A8F97_RS09020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A8F97_RS09025	COG4215	(ABC) transporter
A8F97_RS09030	COG4160	amino acid transport
A8F97_RS09035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A8F97_RS09040	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A8F97_RS09050	COG1177	transmembrane transport
A8F97_RS09055	COG1176	ABC-type spermidine putrescine transport system, permease component I
A8F97_RS09060	COG3842	ATPase activity
A8F97_RS09065	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
A8F97_RS09075	COG0189	ligase activity
A8F97_RS09080	COG0778	Nitroreductase
A8F97_RS09095	COG2985	domain, Protein
A8F97_RS09095	COG0569	domain protein
A8F97_RS09100	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
A8F97_RS09105	COG1349	DNA-binding transcription factor activity
A8F97_RS09110	COG1686	Belongs to the peptidase S11 family
A8F97_RS09115	COG1464	Belongs to the NlpA lipoprotein family
A8F97_RS09120	COG0625	glutathione transferase activity
A8F97_RS09125	COG2133	pyrroloquinoline quinone binding
A8F97_RS09130	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A8F97_RS09135	COG2949	membrane
A8F97_RS09140	COG2311	Membrane
A8F97_RS09145	COG0302	gtp cyclohydrolase
A8F97_RS09150	COG0840	transmembrane signaling receptor activity
A8F97_RS09155	COG0583	DNA-binding transcription factor activity
A8F97_RS09180	COG0371	Dehydrogenase
A8F97_RS09185	COG1129	ABC transporter
A8F97_RS09190	COG1172	Belongs to the binding-protein-dependent transport system permease family
A8F97_RS09195	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A8F97_RS09200	COG4771	TonB-dependent receptor
A8F97_RS09205	COG0833	amino acid
A8F97_RS09210	COG0583	DNA-binding transcription factor activity
A8F97_RS09215	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
A8F97_RS09220	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
A8F97_RS09220	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A8F97_RS09220	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A8F97_RS09225	COG1105	Belongs to the carbohydrate kinase PfkB family
A8F97_RS09245	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A8F97_RS09250	COG0523	cobalamin synthesis protein
A8F97_RS09255	COG0671	phosphoesterase, PA-phosphatase related
A8F97_RS09260	COG0791	NLP P60 protein
A8F97_RS09265	COG4166	transmembrane transport
A8F97_RS09270	COG4174	ABC transporter (Permease)
A8F97_RS09275	COG4239	(ABC) transporter, permease
A8F97_RS09280	COG4172	Belongs to the ABC transporter superfamily
A8F97_RS09290	COG2814	Major facilitator Superfamily
A8F97_RS09305	COG1061	Type III restriction enzyme res subunit
A8F97_RS09310	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
A8F97_RS09320	COG3081	Nucleoid-associated protein
A8F97_RS09325	COG3082	Protein of unknown function (DUF1414)
A8F97_RS09330	COG3083	sulfuric ester hydrolase activity
A8F97_RS09340	COG0582	viral genome integration into host DNA
A8F97_RS09345	COG1702	phosphate starvation-inducible protein PhoH
A8F97_RS09355	COG1191	sigma factor activity
A8F97_RS09360	COG4797	methyltransferase
A8F97_RS09360	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A8F97_RS09385	COG1677	Flagellar hook-basal body complex protein FliE
A8F97_RS09395	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A8F97_RS09400	COG1317	bacterial-type flagellum organization
A8F97_RS09420	COG1580	Controls the rotational direction of flagella during chemotaxis
A8F97_RS09455	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A8F97_RS09470	COG1706	bacterial-type flagellum-dependent cell motility
A8F97_RS09475	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
A8F97_RS09485	COG4787	bacterial-type flagellum-dependent cell motility
A8F97_RS09490	COG1749	Flagellar hook protein flgE
A8F97_RS09495	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
A8F97_RS09500	COG1558	bacterial-type flagellum-dependent cell motility
A8F97_RS09505	COG1815	bacterial-type flagellum-dependent cell motility
A8F97_RS09515	COG2747	anti-sigma28 factor FlgM
A8F97_RS09520	COG3418	PFAM FlgN family protein
A8F97_RS09530	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A8F97_RS09535	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A8F97_RS09545	COG0745	RESPONSE REGULATOR receiver
A8F97_RS09550	COG2201	protein-glutamate methylesterase activity
A8F97_RS09555	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
A8F97_RS09560	COG0840	transmembrane signaling receptor activity
A8F97_RS09565	COG0835	chemotaxis
A8F97_RS09570	COG0643	Histidine kinase
A8F97_RS09570	COG2198	Histidine kinase
A8F97_RS09600	COG0840	transmembrane signaling receptor activity
A8F97_RS09610	COG3706	GGDEF domain
A8F97_RS09620	COG0640	Transcriptional regulator
A8F97_RS09625	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A8F97_RS09630	COG0625	glutathione transferase activity
A8F97_RS09635	COG2814	Major facilitator Superfamily
A8F97_RS09640	COG3226	Transcriptional regulator
A8F97_RS09650	COG0835	chemotaxis
A8F97_RS09650	COG0784	Response regulator, receiver
A8F97_RS09675	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A8F97_RS09695	COG4172	Belongs to the ABC transporter superfamily
A8F97_RS09710	COG0747	negative chemotaxis
A8F97_RS09715	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A8F97_RS09720	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A8F97_RS09735	COG0840	transmembrane signaling receptor activity
A8F97_RS09740	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A8F97_RS09745	COG1012	belongs to the aldehyde dehydrogenase family
A8F97_RS09765	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
A8F97_RS09775	COG2515	1-aminocyclopropane-1-carboxylate deaminase
A8F97_RS09785	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A8F97_RS09795	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
A8F97_RS09810	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A8F97_RS09815	COG0371	Dehydrogenase
A8F97_RS09820	COG1301	dicarboxylic acid transport
A8F97_RS09835	COG0697	spore germination
A8F97_RS09840	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A8F97_RS09845	COG0577	efflux transmembrane transporter activity
A8F97_RS09845	COG1136	(ABC) transporter
A8F97_RS09855	COG0577	efflux transmembrane transporter activity
A8F97_RS09855	COG1136	(ABC) transporter
A8F97_RS09870	COG0672	)-iron permease
A8F97_RS09880	COG3383	formate dehydrogenase (NAD+) activity
A8F97_RS09885	COG1301	dicarboxylic acid transport
A8F97_RS09890	COG0583	DNA-binding transcription factor activity
A8F97_RS09905	COG1464	Belongs to the NlpA lipoprotein family
A8F97_RS09920	COG2271	Major facilitator Superfamily
A8F97_RS09925	COG1840	ABC-type Fe3 transport system, periplasmic component
A8F97_RS09935	COG3842	ATPase activity
A8F97_RS09940	COG1609	Transcriptional regulator
A8F97_RS09945	COG3250	beta-galactosidase activity
A8F97_RS09950	COG2223	nitrite transmembrane transporter activity
A8F97_RS09960	COG0582	viral genome integration into host DNA
A8F97_RS10035	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A8F97_RS10095	COG0640	Transcriptional regulator
A8F97_RS10155	COG0582	viral genome integration into host DNA
A8F97_RS10165	COG3228	Belongs to the MtfA family
A8F97_RS10180	COG1403	HNH endonuclease
A8F97_RS10185	COG4974	Belongs to the 'phage' integrase family
A8F97_RS10270	COG4695	Portal protein
A8F97_RS10310	COG3772	lysozyme
A8F97_RS10330	COG3093	addiction module antidote protein HigA
A8F97_RS10335	COG3549	Plasmid maintenance system killer
A8F97_RS10370	COG5301	cellulose 1,4-beta-cellobiosidase activity
A8F97_RS10425	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A8F97_RS10430	COG0322	excinuclease ABC activity
A8F97_RS10435	COG2197	response regulator
A8F97_RS10455	COG1113	amino acid transport
A8F97_RS10475	COG0582	viral genome integration into host DNA
A8F97_RS10615	COG4974	Belongs to the 'phage' integrase family
A8F97_RS10655	COG0582	viral genome integration into host DNA
A8F97_RS10670	COG3423	Transcriptional regulator
A8F97_RS10695	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A8F97_RS10745	COG3736	Type IV secretory pathway, component VirB8
A8F97_RS10750	COG3504	Conjugal transfer protein
A8F97_RS10760	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
A8F97_RS10820	COG2963	transposase activity
A8F97_RS10830	COG2801	Transposase and inactivated derivatives
A8F97_RS10855	COG0582	viral genome integration into host DNA
A8F97_RS10930	COG0640	Transcriptional regulator
A8F97_RS10970	COG3311	Transcriptional regulator
A8F97_RS11005	COG0300	oxidoreductase activity
A8F97_RS11010	COG0659	secondary active sulfate transmembrane transporter activity
A8F97_RS11015	COG4948	Mandelate Racemase Muconate Lactonizing
A8F97_RS11030	COG1902	pentaerythritol trinitrate reductase activity
A8F97_RS11035	COG0640	Transcriptional regulator
A8F97_RS11040	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
A8F97_RS11045	COG4807	Protein conserved in bacteria
A8F97_RS11050	COG5464	transposase or invertase
A8F97_RS11055	COG1648	precorrin-2 dehydrogenase activity
A8F97_RS11055	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A8F97_RS11060	COG0243	molybdopterin cofactor binding
A8F97_RS11065	COG2146	nitrite reductase [NAD(P)H] activity
A8F97_RS11065	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A8F97_RS11070	COG1116	anion transmembrane transporter activity
A8F97_RS11080	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A8F97_RS11085	COG3707	response regulator
A8F97_RS11100	COG1271	oxidase subunit
A8F97_RS11105	COG1294	oxidase, subunit
A8F97_RS11110	COG4890	Cyd operon protein YbgT
A8F97_RS11115	COG0641	radical SAM
A8F97_RS11120	COG1263	PTS System
A8F97_RS11120	COG2190	(PTS) system
A8F97_RS11120	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A8F97_RS11135	COG1737	Transcriptional regulator
A8F97_RS11140	COG2149	membrane
A8F97_RS11150	COG3058	Necessary for formate dehydrogenase activity
A8F97_RS11155	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A8F97_RS11185	COG4771	TonB-dependent receptor
A8F97_RS11190	COG0488	(ABC) transporter
A8F97_RS11200	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A8F97_RS11215	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A8F97_RS11225	COG2223	nitrite transmembrane transporter activity
A8F97_RS11235	COG1263	PTS System
A8F97_RS11235	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A8F97_RS11240	COG0366	Alpha amylase catalytic
A8F97_RS11245	COG4575	ribosome binding
A8F97_RS11250	COG1007	ATP synthesis coupled electron transport
A8F97_RS11255	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A8F97_RS11260	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A8F97_RS11265	COG0713	ATP synthesis coupled electron transport
A8F97_RS11270	COG0839	Belongs to the complex I subunit 6 family
A8F97_RS11275	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A8F97_RS11280	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
A8F97_RS11290	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
A8F97_RS11295	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
A8F97_RS11300	COG0649	NAD binding
A8F97_RS11300	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A8F97_RS11305	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A8F97_RS11310	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A8F97_RS11315	COG0583	DNA-binding transcription factor activity
A8F97_RS11320	COG0436	Aminotransferase
A8F97_RS11325	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
A8F97_RS11330	COG0471	metal ion transport
A8F97_RS11330	COG0490	domain, Protein
A8F97_RS11335	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A8F97_RS11340	COG3013	Belongs to the UPF0304 family
A8F97_RS11345	COG3092	negative regulation of chromosome organization
A8F97_RS11350	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A8F97_RS11355	COG0280	phosphate acetyltransferase
A8F97_RS11355	COG0857	belongs to the CobB CobQ family
A8F97_RS11360	COG3739	integral membrane protein
A8F97_RS11365	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
A8F97_RS11370	COG0622	Phosphoesterase
A8F97_RS11375	COG0625	glutathione transferase activity
A8F97_RS11380	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A8F97_RS11385	COG1090	epimerase
A8F97_RS11390	COG4598	ABC transporter
A8F97_RS11395	COG4160	amino acid transport
A8F97_RS11400	COG4215	(ABC) transporter
A8F97_RS11410	COG0163	prenyltransferase activity
A8F97_RS11415	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A8F97_RS11420	COG1286	toxin biosynthetic process
A8F97_RS11425	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
A8F97_RS11430	COG0285	dihydrofolate synthase activity
A8F97_RS11435	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
A8F97_RS11445	COG0586	Pfam SNARE associated Golgi protein
A8F97_RS11450	COG0101	tRNA pseudouridine synthase activity
A8F97_RS11455	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A8F97_RS11460	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A8F97_RS11465	COG0697	spore germination
A8F97_RS11480	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A8F97_RS11485	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
A8F97_RS11485	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A8F97_RS11495	COG3101	peptidyl-lysine hydroxylation
A8F97_RS11500	COG0730	response to heat
A8F97_RS11505	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
A8F97_RS11510	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A8F97_RS11515	COG2890	protein-(glutamine-N5) methyltransferase activity
A8F97_RS11520	COG2840	Smr protein MutS2
A8F97_RS11525	COG2062	phosphohistidine phosphatase, SixA
A8F97_RS11545	COG3188	usher protein
A8F97_RS11555	COG1250	3-hydroxyacyl-CoA dehydrogenase
A8F97_RS11555	COG1024	Enoyl-CoA hydratase
A8F97_RS11560	COG0183	Belongs to the thiolase family
A8F97_RS11565	COG3691	Protein conserved in bacteria
A8F97_RS11570	COG2067	long-chain fatty acid transport protein
A8F97_RS11575	COG1028	Short-chain dehydrogenase reductase Sdr
A8F97_RS11580	COG0583	DNA-binding transcription factor activity
A8F97_RS11585	COG0579	oxidoreductase
A8F97_RS11600	COG0582	viral genome integration into host DNA
A8F97_RS11625	COG3561	AntA/AntB antirepressor
A8F97_RS11745	COG0513	Belongs to the DEAD box helicase family
A8F97_RS11755	COG1120	ATPase activity
A8F97_RS11760	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A8F97_RS11765	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A8F97_RS11770	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A8F97_RS11840	COG3266	domain, Protein
A8F97_RS11850	COG0436	Aminotransferase
A8F97_RS11855	COG4948	Mandelate Racemase Muconate Lactonizing
A8F97_RS11865	COG3264	Mechanosensitive ion channel
A8F97_RS11865	COG1511	domain protein
A8F97_RS11875	COG0582	viral genome integration into host DNA
A8F97_RS11885	COG3077	Addiction module antitoxin, RelB DinJ family
A8F97_RS11900	COG0515	serine threonine protein kinase
A8F97_RS11905	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A8F97_RS11910	COG0210	DNA helicase
A8F97_RS11940	COG3596	GTP binding
A8F97_RS11945	COG2378	regulation of single-species biofilm formation
A8F97_RS11965	COG2003	Belongs to the UPF0758 family
A8F97_RS11995	COG0582	viral genome integration into host DNA
A8F97_RS12015	COG0443	Heat shock 70 kDa protein
A8F97_RS12055	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A8F97_RS12065	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A8F97_RS12070	COG1696	Membrane protein involved in D-alanine export
A8F97_RS12100	COG3842	ATPase activity
A8F97_RS12105	COG2076	Multidrug Resistance protein
A8F97_RS12110	COG2076	Multidrug Resistance protein
A8F97_RS12115	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
A8F97_RS12120	COG0726	polysaccharide deacetylase
A8F97_RS12125	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A8F97_RS12125	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A8F97_RS12130	COG0463	Glycosyl transferase, family 2
A8F97_RS12135	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A8F97_RS12140	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
A8F97_RS12145	COG5001	Diguanylate cyclase
A8F97_RS12145	COG4251	negative regulation of phosphorylation
A8F97_RS12145	COG2203	Gaf domain
A8F97_RS12145	COG3706	GGDEF domain
A8F97_RS12150	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A8F97_RS12155	COG2501	S4 domain
A8F97_RS12160	COG0215	cysteine-tRNA ligase activity
A8F97_RS12170	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A8F97_RS12175	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A8F97_RS12180	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A8F97_RS12185	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A8F97_RS12190	COG0814	amino acid
A8F97_RS12205	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A8F97_RS12210	COG0581	inorganic phosphate transmembrane transporter activity
A8F97_RS12215	COG0573	inorganic phosphate transmembrane transporter activity
A8F97_RS12220	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
A8F97_RS12235	COG1764	response to oxidative stress
A8F97_RS12240	COG1846	Transcriptional regulator
A8F97_RS12245	COG2239	Acts as a magnesium transporter
A8F97_RS12255	COG1085	galactose-1-phosphate uridylyltransferase
A8F97_RS12260	COG1609	Transcriptional regulator
A8F97_RS12265	COG4580	involved in the transport of maltose and maltodextrins
A8F97_RS12275	COG2182	Extracellular solute-binding protein
A8F97_RS12280	COG1175	transmembrane transport
A8F97_RS12285	COG3833	ABC-type maltose transport systems, permease component
A8F97_RS12290	COG3867	Arabinogalactan endo-beta-1,4-galactanase
A8F97_RS12295	COG1874	Beta-galactosidase
A8F97_RS12305	COG0277	FAD linked oxidase domain protein
A8F97_RS12315	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A8F97_RS12320	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A8F97_RS12325	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A8F97_RS12330	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A8F97_RS12335	COG0477	Major facilitator Superfamily
A8F97_RS12340	COG2205	protein histidine kinase activity
A8F97_RS12345	COG0745	RESPONSE REGULATOR receiver
A8F97_RS12355	COG0435	Glutathione S-transferase
A8F97_RS12360	COG0826	peptidase U32
A8F97_RS12365	COG1597	lipid kinase activity
A8F97_RS12370	COG3223	Belongs to the PsiE family
A8F97_RS12375	COG0351	phosphomethylpyrimidine kinase
A8F97_RS12380	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
A8F97_RS12395	COG0583	DNA-binding transcription factor activity
A8F97_RS12400	COG3493	citrate carrier protein
A8F97_RS12405	COG0179	Fumarylacetoacetate (FAA) hydrolase
A8F97_RS12410	COG0066	3-isopropylmalate dehydratase activity
A8F97_RS12415	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A8F97_RS12420	COG1064	alcohol dehydrogenase
A8F97_RS12435	COG1064	alcohol dehydrogenase
A8F97_RS12490	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
A8F97_RS12505	COG0667	Aldo Keto reductase
A8F97_RS12520	COG0519	Catalyzes the synthesis of GMP from XMP
A8F97_RS12520	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A8F97_RS12530	COG1570	exodeoxyribonuclease VII activity
A8F97_RS12545	COG1645	bacterial-type flagellum-dependent swarming motility
A8F97_RS12555	COG1160	GTP binding
A8F97_RS12560	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A8F97_RS12565	COG2976	Protein conserved in bacteria
A8F97_RS12570	COG0124	histidyl-tRNA synthetase
A8F97_RS12575	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
A8F97_RS12580	COG1426	Protein conserved in bacteria
A8F97_RS12590	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A8F97_RS12595	COG0105	UTP biosynthetic process
A8F97_RS12600	COG2897	thiosulfate sulfurtransferase activity
A8F97_RS12610	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A8F97_RS12615	COG2975	iron-sulfur cluster assembly
A8F97_RS12620	COG0633	Ferredoxin
A8F97_RS12625	COG0443	Heat shock 70 kDa protein
A8F97_RS12630	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
A8F97_RS12635	COG0316	Belongs to the HesB IscA family
A8F97_RS12640	COG0822	iron-sulfur transferase activity
A8F97_RS12645	COG1104	cysteine desulfurase activity
A8F97_RS12650	COG1959	2 iron, 2 sulfur cluster binding
A8F97_RS12655	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
A8F97_RS12660	COG0483	inositol monophosphate 1-phosphatase activity
A8F97_RS12670	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A8F97_RS12675	COG1120	ATPase activity
A8F97_RS12685	COG0840	transmembrane signaling receptor activity
A8F97_RS12695	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
A8F97_RS12700	COG3683	transport system, periplasmic component
A8F97_RS12705	COG2814	Major facilitator Superfamily
A8F97_RS12710	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A8F97_RS12715	COG1017	nitric oxide dioxygenase activity
A8F97_RS12715	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A8F97_RS12725	COG4677	pectinesterase activity
A8F97_RS12730	COG0347	Belongs to the P(II) protein family
A8F97_RS12735	COG2204	response regulator
A8F97_RS12740	COG3170	Tfp pilus assembly protein FimV
A8F97_RS12745	COG2205	protein histidine kinase activity
A8F97_RS12750	COG0047	phosphoribosylformylglycinamidine synthase activity
A8F97_RS12750	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A8F97_RS12755	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
A8F97_RS12765	COG0560	Phosphoserine phosphatase
A8F97_RS12770	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
A8F97_RS12780	COG2199	diguanylate cyclase activity
A8F97_RS12780	COG3287	FIST C domain
A8F97_RS12780	COG2200	EAL domain
A8F97_RS12805	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A8F97_RS12820	COG2200	EAL domain
A8F97_RS12825	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A8F97_RS12830	COG0736	holo-[acyl-carrier-protein] synthase activity
A8F97_RS12835	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
A8F97_RS12840	COG1381	Involved in DNA repair and RecF pathway recombination
A8F97_RS12845	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A8F97_RS12850	COG0571	ribonuclease III activity
A8F97_RS12860	COG0481	GTPase activity
A8F97_RS12865	COG3086	response to oxidative stress
A8F97_RS12870	COG3026	antisigma factor binding
A8F97_RS12885	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
A8F97_RS12890	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
A8F97_RS12895	COG0513	Belongs to the DEAD box helicase family
A8F97_RS12900	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
A8F97_RS12905	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
A8F97_RS12920	COG2819	hydrolase of the alpha beta superfamily
A8F97_RS12925	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A8F97_RS12955	COG1902	pentaerythritol trinitrate reductase activity
A8F97_RS12960	COG0667	Aldo Keto reductase
A8F97_RS12965	COG1309	transcriptional regulator
A8F97_RS12975	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
A8F97_RS12980	COG4208	sulfate ABC transporter
A8F97_RS12990	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
A8F97_RS12995	COG3835	regulator
A8F97_RS13000	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A8F97_RS13005	COG0232	Belongs to the dGTPase family. Type 2 subfamily
A8F97_RS13010	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A8F97_RS13015	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A8F97_RS13025	COG0316	Belongs to the HesB IscA family
A8F97_RS13030	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A8F97_RS13035	COG0625	glutathione transferase activity
A8F97_RS13040	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A8F97_RS13050	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A8F97_RS13055	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A8F97_RS13060	COG1120	ATPase activity
A8F97_RS13065	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A8F97_RS13070	COG1643	Atp-dependent helicase
A8F97_RS13075	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
A8F97_RS13080	COG1489	DNA binding
A8F97_RS13090	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A8F97_RS13100	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A8F97_RS13105	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
A8F97_RS13110	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
A8F97_RS13115	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
A8F97_RS13120	COG0842	Transport permease protein
A8F97_RS13125	COG1131	(ABC) transporter
A8F97_RS13130	COG0288	reversible hydration of carbon dioxide
A8F97_RS13145	COG3842	ATPase activity
A8F97_RS13160	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A8F97_RS13165	COG1780	Probably involved in ribonucleotide reductase function
A8F97_RS13175	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A8F97_RS13190	COG0328	RNA-DNA hybrid ribonuclease activity
A8F97_RS13195	COG2226	methyltransferase
A8F97_RS13200	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A8F97_RS13205	COG0741	lytic transglycosylase activity
A8F97_RS13205	COG1388	LysM domain
A8F97_RS13210	COG3021	interspecies interaction between organisms
A8F97_RS13245	COG0542	response to heat
A8F97_RS13255	COG0564	pseudouridine synthase activity
A8F97_RS13260	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A8F97_RS13265	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A8F97_RS13270	COG0077	Prephenate dehydratase
A8F97_RS13270	COG1605	Chorismate mutase
A8F97_RS13275	COG1605	Chorismate mutase
A8F97_RS13275	COG0287	Prephenate dehydrogenase
A8F97_RS13280	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A8F97_RS13285	COG3279	Response regulator of the LytR AlgR family
A8F97_RS13295	COG2264	protein methyltransferase activity
A8F97_RS13300	COG0335	large ribosomal subunit rRNA binding
A8F97_RS13305	COG0336	Belongs to the RNA methyltransferase TrmD family
A8F97_RS13310	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A8F97_RS13315	COG0228	four-way junction DNA binding
A8F97_RS13320	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A8F97_RS13325	COG4137	Cytochrome C assembly protein
A8F97_RS13330	COG1854	S-ribosylhomocysteine lyase activity
A8F97_RS13335	COG2918	glutathione biosynthetic process
A8F97_RS13340	COG1238	metal cluster binding
A8F97_RS13345	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A8F97_RS13370	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
A8F97_RS13375	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A8F97_RS13380	COG2137	regulation of response to DNA damage stimulus
A8F97_RS13385	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A8F97_RS13390	COG1546	Belongs to the CinA family
A8F97_RS13415	COG2814	Major facilitator Superfamily
A8F97_RS13420	COG0583	DNA-binding transcription factor activity
A8F97_RS13425	COG2999	glutathione oxidoreductase activity
A8F97_RS13550	COG3829	transcription factor binding
A8F97_RS13650	COG3121	Chaperone
A8F97_RS13665	COG4773	Receptor
A8F97_RS13670	COG2843	Capsule synthesis protein
A8F97_RS13675	COG0626	cystathionine gamma-synthase activity
A8F97_RS13685	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A8F97_RS13690	COG0765	amino acid transport
A8F97_RS13695	COG0765	amino acid transport
A8F97_RS13700	COG1126	abc transporter atp-binding protein
A8F97_RS13705	COG2897	thiosulfate sulfurtransferase activity
A8F97_RS13710	COG0673	inositol 2-dehydrogenase activity
A8F97_RS13735	COG2814	Major facilitator Superfamily
A8F97_RS13745	COG1802	Transcriptional regulator
A8F97_RS13750	COG0246	Mannitol dehydrogenase
A8F97_RS13755	COG0477	Major facilitator Superfamily
A8F97_RS13760	COG1063	alcohol dehydrogenase
A8F97_RS13765	COG4948	Mandelate Racemase Muconate Lactonizing
A8F97_RS13770	COG0583	DNA-binding transcription factor activity
A8F97_RS13780	COG0437	4 iron, 4 sulfur cluster binding
A8F97_RS13785	COG3301	Polysulphide reductase, NrfD
A8F97_RS13790	COG0477	Major facilitator Superfamily
A8F97_RS13795	COG3976	FMN-binding domain protein
A8F97_RS13795	COG1053	succinate dehydrogenase
A8F97_RS13795	COG0431	NADPH-dependent FMN reductase
A8F97_RS13810	COG2169	Transcriptional regulator
A8F97_RS13810	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A8F97_RS13825	COG0583	DNA-binding transcription factor activity
A8F97_RS13830	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
A8F97_RS13830	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
A8F97_RS13835	COG3604	Transcriptional regulator
A8F97_RS13840	COG1773	rubredoxin
A8F97_RS13840	COG0426	domain, Protein
A8F97_RS13845	COG0446	pyridine nucleotide-disulphide oxidoreductase
A8F97_RS13855	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A8F97_RS13865	COG0531	amino acid
A8F97_RS13870	COG3115	cell septum assembly
A8F97_RS13875	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
A8F97_RS13885	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A8F97_RS13895	COG2190	(PTS) system
A8F97_RS13900	COG2205	protein histidine kinase activity
A8F97_RS13905	COG0745	RESPONSE REGULATOR receiver
A8F97_RS13910	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A8F97_RS13915	COG0577	efflux transmembrane transporter activity
A8F97_RS13915	COG1136	(ABC) transporter
A8F97_RS13920	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A8F97_RS13925	COG4208	sulfate ABC transporter
A8F97_RS13930	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
A8F97_RS13935	COG4150	thiosulfate binding
A8F97_RS13940	COG2837	iron assimilation
A8F97_RS13950	COG4178	(ABC) transporter
A8F97_RS13955	COG0612	Peptidase, M16
A8F97_RS13960	COG4771	TonB-dependent receptor
A8F97_RS13975	COG0456	acetyltransferase
A8F97_RS13980	COG0408	coproporphyrinogen oxidase activity
A8F97_RS13985	COG1671	Belongs to the UPF0178 family
A8F97_RS13990	COG0814	amino acid
A8F97_RS14000	COG2390	Transcriptional regulator
A8F97_RS14005	COG0149	triose-phosphate isomerase activity
A8F97_RS14015	COG3395	kinase activity
A8F97_RS14030	COG0698	ribose 5-phosphate isomerase
A8F97_RS14035	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A8F97_RS14040	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A8F97_RS14045	COG1263	PTS System
A8F97_RS14045	COG2190	(PTS) system
A8F97_RS14045	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A8F97_RS14050	COG2723	6-phospho-beta-galactosidase activity
A8F97_RS14055	COG3711	transcriptional antiterminator
A8F97_RS14060	COG1609	Transcriptional regulator
A8F97_RS14090	COG0494	nUDIX hydrolase
A8F97_RS14095	COG1942	4-Oxalocrotonate Tautomerase
A8F97_RS14110	COG1914	H( )-stimulated, divalent metal cation uptake system
A8F97_RS14115	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A8F97_RS14120	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A8F97_RS14125	COG0497	DNA recombination
A8F97_RS14135	COG2914	Belongs to the UPF0125 (RnfH) family
A8F97_RS14140	COG2867	negative regulation of translational initiation
A8F97_RS14145	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A8F97_RS14155	COG0582	viral genome integration into host DNA
A8F97_RS14245	COG1280	lysine exporter protein (LysE YggA)
A8F97_RS14255	COG2211	Major facilitator Superfamily
A8F97_RS14270	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A8F97_RS14270	COG1013	pyruvate-flavodoxin oxidoreductase activity
A8F97_RS14270	COG0674	pyruvate-flavodoxin oxidoreductase activity
A8F97_RS14270	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
A8F97_RS14275	COG3038	cytochrome b561
A8F97_RS14280	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A8F97_RS14285	COG1376	ErfK ybiS ycfS ynhG family protein
A8F97_RS14290	COG2873	o-acetylhomoserine
A8F97_RS14295	COG0246	Mannitol dehydrogenase
A8F97_RS14340	COG3964	amidohydrolase
A8F97_RS14355	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A8F97_RS14355	COG3711	transcriptional antiterminator
A8F97_RS14365	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A8F97_RS14370	COG3162	membrane
A8F97_RS14375	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A8F97_RS14380	COG5464	transposase or invertase
A8F97_RS14460	COG4964	Belongs to the GSP D family
A8F97_RS14480	COG3850	Histidine kinase
A8F97_RS14480	COG5002	protein histidine kinase activity
A8F97_RS14490	COG0025	NhaP-type Na H and K H
A8F97_RS14495	COG2252	PERMEase
A8F97_RS14505	COG1560	Kdo2-lipid A biosynthetic process
A8F97_RS14605	COG0582	viral genome integration into host DNA
A8F97_RS14625	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A8F97_RS14630	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A8F97_RS14635	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A8F97_RS14640	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A8F97_RS14645	COG4974	Belongs to the 'phage' integrase family
A8F97_RS14650	COG0477	Major facilitator Superfamily
A8F97_RS14655	COG1464	Belongs to the NlpA lipoprotein family
A8F97_RS14660	COG2011	ABC-type metal ion transport system permease component
A8F97_RS14665	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A8F97_RS14670	COG0716	FMN binding
A8F97_RS14680	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
A8F97_RS14690	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
A8F97_RS14695	COG0354	folic acid binding
A8F97_RS14700	COG1272	protein, Hemolysin III
A8F97_RS14720	COG2211	Major facilitator Superfamily
A8F97_RS14725	COG1653	transport
A8F97_RS14735	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
A8F97_RS14745	COG1175	transmembrane transport
A8F97_RS14750	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A8F97_RS14750	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A8F97_RS14755	COG0509	glycine decarboxylation via glycine cleavage system
A8F97_RS14760	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A8F97_RS14765	COG1454	alcohol dehydrogenase
A8F97_RS14810	COG0656	L-ascorbic acid biosynthetic process
A8F97_RS14815	COG2813	Specifically methylates the guanine in position
A8F97_RS14820	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
A8F97_RS14825	COG0456	acetyltransferase
A8F97_RS14840	COG0813	purine-nucleoside phosphorylase activity
A8F97_RS14845	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
A8F97_RS14850	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
A8F97_RS14860	COG2827	Endonuclease containing a URI domain
A8F97_RS14865	COG3153	acetyltransferase
A8F97_RS14870	COG3154	lipid carrier protein
A8F97_RS14875	COG0826	peptidase U32
A8F97_RS14880	COG0826	peptidase U32
A8F97_RS14885	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A8F97_RS14890	COG2194	sulfuric ester hydrolase activity
A8F97_RS14895	COG0513	Belongs to the DEAD box helicase family
A8F97_RS14905	COG1185	polyribonucleotide nucleotidyltransferase activity
A8F97_RS14910	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A8F97_RS14915	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A8F97_RS14920	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A8F97_RS14925	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A8F97_RS14935	COG0779	Required for maturation of 30S ribosomal subunits
A8F97_RS14950	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A8F97_RS14955	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A8F97_RS14960	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A8F97_RS14965	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A8F97_RS14970	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
A8F97_RS14975	COG1534	Rna-binding protein
A8F97_RS14985	COG2027	D-alanyl-D-alanine carboxypeptidase
A8F97_RS14990	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A8F97_RS14995	COG0697	spore germination
A8F97_RS15000	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A8F97_RS15005	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A8F97_RS15010	COG0142	geranyltranstransferase activity
A8F97_RS15025	COG3423	Transcriptional regulator
A8F97_RS15030	COG0039	L-malate dehydrogenase activity
A8F97_RS15035	COG1438	arginine binding
A8F97_RS15040	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A8F97_RS15045	COG0828	Belongs to the bacterial ribosomal protein bS21 family
A8F97_RS15050	COG0358	DNA primase activity
A8F97_RS15060	COG3663	DNA glycosylase
A8F97_RS15085	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A8F97_RS15095	COG2188	Transcriptional regulator
A8F97_RS15100	COG0583	DNA-binding transcription factor activity
A8F97_RS15110	COG0243	molybdopterin cofactor binding
A8F97_RS15125	COG1609	Transcriptional regulator
A8F97_RS15130	COG1263	PTS System
A8F97_RS15130	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A8F97_RS15135	COG1554	hydrolase, family 65, central catalytic
A8F97_RS15140	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A8F97_RS15150	COG3119	arylsulfatase activity
A8F97_RS15150	COG3408	Glycogen debranching enzyme
A8F97_RS15155	COG0641	radical SAM
A8F97_RS15160	COG3119	arylsulfatase activity
A8F97_RS15185	COG2199	diguanylate cyclase activity
A8F97_RS15190	COG3678	ATP-independent chaperone mediated protein folding
A8F97_RS15200	COG0446	pyridine nucleotide-disulphide oxidoreductase
A8F97_RS15200	COG1902	pentaerythritol trinitrate reductase activity
A8F97_RS15205	COG2813	Specifically methylates the guanine in position
A8F97_RS15210	COG0673	inositol 2-dehydrogenase activity
A8F97_RS15215	COG0861	Integral membrane protein TerC family
A8F97_RS15220	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
A8F97_RS15230	COG2721	sulfolactate sulfo-lyase activity
A8F97_RS15235	COG0246	Mannitol dehydrogenase
A8F97_RS15240	COG1904	glucuronate isomerase
A8F97_RS15245	COG2271	Major facilitator Superfamily
A8F97_RS15255	COG0586	Pfam SNARE associated Golgi protein
A8F97_RS15265	COG4575	ribosome binding
A8F97_RS15270	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
A8F97_RS15280	COG2259	Doxx family
A8F97_RS15285	COG0435	Glutathione S-transferase
A8F97_RS15290	COG0583	DNA-binding transcription factor activity
A8F97_RS15295	COG1741	Belongs to the pirin family
A8F97_RS15300	COG0735	belongs to the Fur family
A8F97_RS15310	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
A8F97_RS15315	COG2937	Belongs to the GPAT DAPAT family
A8F97_RS15320	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
A8F97_RS15325	COG3161	chorismate lyase activity
A8F97_RS15335	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A8F97_RS15350	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
A8F97_RS15355	COG1324	tolerance protein
A8F97_RS15360	COG4232	protein-disulfide reductase activity
A8F97_RS15365	COG1309	transcriptional regulator
A8F97_RS15400	COG2226	methyltransferase
A8F97_RS15410	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A8F97_RS15425	COG1045	serine acetyltransferase
A8F97_RS15440	COG0438	transferase activity, transferring glycosyl groups
A8F97_RS15445	COG0297	glycogen (starch) synthase activity
A8F97_RS15485	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A8F97_RS15490	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
A8F97_RS15495	COG3454	Phosphonate metabolism
A8F97_RS15500	COG4778	phosphonate C-P lyase system protein PhnL
A8F97_RS15505	COG4107	phosphonate C-P lyase system protein PhnK
A8F97_RS15510	COG3627	carbon phosphorus lyase activity
A8F97_RS15515	COG3626	phosphonate metabolism
A8F97_RS15520	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
A8F97_RS15525	COG3624	Phosphonate C-P lyase system protein PhnG
A8F97_RS15530	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
A8F97_RS15535	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
A8F97_RS15535	COG0028	Belongs to the TPP enzyme family
A8F97_RS15580	COG1028	Short-chain dehydrogenase reductase Sdr
A8F97_RS15585	COG1021	2,3-dihydroxybenzoate-AMP ligase
A8F97_RS15590	COG1169	isochorismate synthase
A8F97_RS15600	COG4771	TonB-dependent receptor
A8F97_RS15610	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A8F97_RS15615	COG0084	hydrolase, TatD family'
A8F97_RS15625	COG5487	UPF0391 membrane protein
A8F97_RS15630	COG2823	Periplasmic or secreted lipoprotein
A8F97_RS15635	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
A8F97_RS15640	COG3550	peptidyl-serine autophosphorylation
A8F97_RS15645	COG3620	sequence-specific DNA binding
A8F97_RS15650	COG3726	membrane protein affecting hemolysin expression
A8F97_RS15655	COG0560	Phosphoserine phosphatase
A8F97_RS15670	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A8F97_RS15680	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
A8F97_RS15685	COG3079	Belongs to the UPF0149 family
A8F97_RS15690	COG0006	proline dipeptidase activity
A8F97_RS15695	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A8F97_RS15700	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A8F97_RS15730	COG2963	transposase activity
A8F97_RS15775	COG3209	COG3209 Rhs family protein
A8F97_RS15840	COG2130	NADP-dependent
A8F97_RS15845	COG2862	Uncharacterized protein family, UPF0114
A8F97_RS15860	COG3477	response to acidic pH
A8F97_RS15865	COG0747	negative chemotaxis
A8F97_RS15870	COG0601	transmembrane transport
A8F97_RS15875	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A8F97_RS15885	COG2161	toxin-antitoxin pair type II binding
A8F97_RS15890	COG4115	mRNA cleavage
A8F97_RS15895	COG1917	Cupin 2, conserved barrel domain protein
A8F97_RS15895	COG4977	sequence-specific DNA binding
A8F97_RS15900	COG1917	Cupin 2, conserved barrel domain protein
A8F97_RS15900	COG2169	Transcriptional regulator
A8F97_RS15905	COG1070	Carbohydrate kinase
A8F97_RS15910	COG4806	L-rhamnose isomerase
A8F97_RS15915	COG0235	Class ii aldolase
A8F97_RS15920	COG3254	rhamnose metabolic process
A8F97_RS15925	COG0840	transmembrane signaling receptor activity
A8F97_RS15935	COG0840	transmembrane signaling receptor activity
A8F97_RS15955	COG3541	Predicted nucleotidyltransferase
A8F97_RS15960	COG1690	Belongs to the RtcB family
A8F97_RS15965	COG4650	regulator
A8F97_RS15990	COG0583	DNA-binding transcription factor activity
A8F97_RS16010	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A8F97_RS16030	COG2850	peptidyl-arginine hydroxylation
A8F97_RS16035	COG2304	oxidoreductase activity
A8F97_RS16065	COG1136	(ABC) transporter
A8F97_RS16075	COG1262	PFAM Formylglycine-generating sulfatase enzyme
A8F97_RS16150	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
A8F97_RS16155	COG0582	viral genome integration into host DNA
A8F97_RS16175	COG3311	Transcriptional regulator
A8F97_RS16180	COG3772	lysozyme
A8F97_RS16225	COG0582	viral genome integration into host DNA
A8F97_RS16235	COG0795	lipopolysaccharide-transporting ATPase activity
A8F97_RS16240	COG0795	lipopolysaccharide-transporting ATPase activity
A8F97_RS16245	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A8F97_RS16250	COG2927	DNA polymerase III (CHI subunit)
A8F97_RS16255	COG0525	valine-tRNA ligase activity
A8F97_RS16270	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
A8F97_RS16290	COG3210	domain, Protein
A8F97_RS16295	COG2831	hemolysin activation secretion protein
A8F97_RS16300	COG0840	transmembrane signaling receptor activity
A8F97_RS16305	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A8F97_RS16310	COG0501	Belongs to the peptidase M48B family
A8F97_RS16330	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A8F97_RS16345	COG2731	YhcH YjgK YiaL family protein
A8F97_RS16350	COG0540	Belongs to the ATCase OTCase family
A8F97_RS16355	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
A8F97_RS16365	COG1328	CTP reductase activity
A8F97_RS16370	COG0602	queuosine metabolic process
A8F97_RS16375	COG0702	epimerase
A8F97_RS16380	COG3787	Belongs to the UPF0306 family
A8F97_RS16390	COG2814	Major facilitator Superfamily
A8F97_RS16395	COG0076	glutamate decarboxylase activity
A8F97_RS16405	COG5499	transcription regulator containing HTH domain
A8F97_RS16410	COG4680	protein conserved in bacteria
A8F97_RS16425	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A8F97_RS16430	COG1518	maintenance of DNA repeat elements
A8F97_RS16445	COG1857	crispr-associated protein
A8F97_RS16465	COG1203	CRISPR-associated helicase, Cas3
A8F97_RS16505	COG0848	biopolymer transport protein
A8F97_RS16515	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A8F97_RS16535	COG0586	Pfam SNARE associated Golgi protein
A8F97_RS16540	COG2207	Transcriptional regulator
A8F97_RS16545	COG0778	Nitroreductase
A8F97_RS16550	COG1979	alcohol dehydrogenase
A8F97_RS16555	COG2963	transposase activity
A8F97_RS16565	COG3209	COG3209 Rhs family protein
A8F97_RS16565	COG4104	PAAR repeat-containing protein
A8F97_RS16600	COG3209	COG3209 Rhs family protein
A8F97_RS16600	COG4104	PAAR repeat-containing protein
A8F97_RS16610	COG4104	PAAR repeat-containing protein
A8F97_RS16610	COG3209	COG3209 Rhs family protein
A8F97_RS16640	COG2963	transposase activity
A8F97_RS16665	COG3501	Rhs element vgr protein
A8F97_RS16675	COG0656	L-ascorbic acid biosynthetic process
A8F97_RS16685	COG2132	Multicopper oxidase
A8F97_RS16690	COG0204	Acyl-transferase
A8F97_RS16695	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A8F97_RS16710	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A8F97_RS16710	COG3711	transcriptional antiterminator
A8F97_RS16715	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A8F97_RS16715	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A8F97_RS16715	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A8F97_RS16720	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A8F97_RS16725	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A8F97_RS16725	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A8F97_RS16740	COG2249	NAD(P)H dehydrogenase (quinone) activity
A8F97_RS16745	COG0583	DNA-binding transcription factor activity
A8F97_RS16755	COG3150	esterase
A8F97_RS16760	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
A8F97_RS16765	COG3151	Protein conserved in bacteria
A8F97_RS16770	COG0494	nUDIX hydrolase
A8F97_RS16780	COG5463	Belongs to the UPF0441 family
A8F97_RS16785	COG0754	glutathionylspermidine amidase activity
A8F97_RS16790	COG3384	dioxygenase
A8F97_RS16800	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A8F97_RS16805	COG3107	peptidoglycan biosynthetic process
A8F97_RS16810	COG0792	nuclease activity
A8F97_RS16815	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
A8F97_RS16820	COG2823	Periplasmic or secreted lipoprotein
A8F97_RS16830	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A8F97_RS16835	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
A8F97_RS16840	COG2198	Histidine kinase
A8F97_RS16840	COG5002	protein histidine kinase activity
A8F97_RS16840	COG0784	Response regulator, receiver
A8F97_RS16845	COG1242	4 iron, 4 sulfur cluster binding
A8F97_RS16850	COG0067	glutamate synthase
A8F97_RS16850	COG0069	glutamate synthase activity
A8F97_RS16850	COG0070	glutamate synthase
A8F97_RS16855	COG0493	'glutamate synthase
A8F97_RS16865	COG2969	positive regulation of protein catabolic process
A8F97_RS16870	COG0625	glutathione transferase activity
A8F97_RS16875	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A8F97_RS16880	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A8F97_RS16885	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
A8F97_RS16890	COG3105	Protein conserved in bacteria
A8F97_RS16895	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A8F97_RS16900	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A8F97_RS16905	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A8F97_RS16910	COG5007	Belongs to the BolA IbaG family
A8F97_RS16915	COG3113	response to antibiotic
A8F97_RS16920	COG2854	intermembrane phospholipid transfer
A8F97_RS16925	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A8F97_RS16930	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A8F97_RS16935	COG1127	ABC transporter
A8F97_RS16940	COG0530	calcium, potassium:sodium antiporter activity
A8F97_RS16945	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
A8F97_RS16945	COG0517	IMP dehydrogenase activity
A8F97_RS16950	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
A8F97_RS16955	COG3117	lipopolysaccharide transmembrane transporter activity
A8F97_RS16960	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
A8F97_RS16965	COG1137	ATPase activity
A8F97_RS16970	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
A8F97_RS16975	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A8F97_RS16985	COG1660	Displays ATPase and GTPase activities
A8F97_RS16990	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A8F97_RS16995	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A8F97_RS17000	COG0312	modulator of DNA gyrase
A8F97_RS17005	COG3028	Belongs to the UPF0307 family
A8F97_RS17010	COG1289	transmembrane transporter activity
A8F97_RS17015	COG1566	PFAM secretion protein HlyD family protein
A8F97_RS17025	COG0583	DNA-binding transcription factor activity
A8F97_RS17030	COG0312	modulator of DNA gyrase
A8F97_RS17035	COG3164	Protein of unknown function
A8F97_RS17040	COG1530	ribonuclease E activity
A8F97_RS17045	COG0424	maF-like protein
A8F97_RS17050	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
A8F97_RS17055	COG1792	Involved in formation and maintenance of cell shape
A8F97_RS17060	COG1077	Cell shape determining protein MreB Mrl
A8F97_RS17065	COG2199	diguanylate cyclase activity
A8F97_RS17065	COG2200	EAL domain
A8F97_RS17070	COG0604	alcohol dehydrogenase
A8F97_RS17085	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A8F97_RS17090	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
A8F97_RS17095	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
A8F97_RS17100	COG0511	ligase activity, forming carbon-carbon bonds
A8F97_RS17105	COG0439	Biotin carboxylase
A8F97_RS17115	COG0157	Belongs to the NadC ModD family
A8F97_RS17120	COG0500	methyltransferase
A8F97_RS17125	COG1120	ATPase activity
A8F97_RS17130	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A8F97_RS17140	COG3585	molybdate ion transport
A8F97_RS17145	COG3924	membrane
A8F97_RS17150	COG4145	pantothenate transmembrane transporter activity
A8F97_RS17155	COG2264	protein methyltransferase activity
A8F97_RS17170	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
A8F97_RS17195	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A8F97_RS17200	COG0765	amino acid transport
A8F97_RS17205	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A8F97_RS17210	COG4597	amino acid ABC transporter
A8F97_RS17215	COG0765	amino acid transport
A8F97_RS17220	COG1126	abc transporter atp-binding protein
A8F97_RS17245	COG0138	bifunctional purine biosynthesis protein purh
A8F97_RS17250	COG0151	Belongs to the GarS family
A8F97_RS17270	COG1515	deoxyribonuclease V activity
A8F97_RS17275	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
A8F97_RS17280	COG2816	NAD+ diphosphatase activity
A8F97_RS17285	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
A8F97_RS17290	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
A8F97_RS17295	COG0352	thiamine-phosphate diphosphorylase activity
A8F97_RS17300	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A8F97_RS17305	COG2104	thiamine diphosphate biosynthetic process
A8F97_RS17310	COG2022	thiamine diphosphate biosynthetic process
A8F97_RS17320	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A8F97_RS17325	COG5457	Domain of unknown function (DUF1127)
A8F97_RS17330	COG0477	Major facilitator Superfamily
A8F97_RS17335	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A8F97_RS17340	COG0085	RNA polymerase activity
A8F97_RS17345	COG0222	ribosome binding
A8F97_RS17350	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A8F97_RS17355	COG0081	regulation of translation
A8F97_RS17360	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A8F97_RS17365	COG0250	Participates in transcription elongation, termination and antitermination
A8F97_RS17375	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A8F97_RS17405	COG1072	(Pantothenic acid kinase))
A8F97_RS17410	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
A8F97_RS17410	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
A8F97_RS17415	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A8F97_RS17440	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A8F97_RS17445	COG4206	TonB-dependent receptor
A8F97_RS17450	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A8F97_RS17465	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A8F97_RS17480	COG0460	homoserine dehydrogenase
A8F97_RS17480	COG0527	aspartate kinase activity
A8F97_RS17485	COG0626	cystathionine gamma-synthase activity
A8F97_RS17490	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
A8F97_RS17495	COG1120	ATPase activity
A8F97_RS17505	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A8F97_RS17510	COG0254	rRNA binding
A8F97_RS17515	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A8F97_RS17520	COG1609	Transcriptional regulator
A8F97_RS17525	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A8F97_RS17530	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
A8F97_RS17535	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
A8F97_RS17540	COG1575	Belongs to the MenA family. Type 1 subfamily
A8F97_RS17545	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A8F97_RS17550	COG3074	FtsZ-dependent cytokinesis
A8F97_RS17555	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A8F97_RS17560	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A8F97_RS17565	COG1494	fructose-1,6-bisphosphatase
A8F97_RS17575	COG3152	Membrane
A8F97_RS17585	COG0149	triose-phosphate isomerase activity
A8F97_RS17590	COG2957	Belongs to the agmatine deiminase family
A8F97_RS17595	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A8F97_RS17670	COG3209	COG3209 Rhs family protein
A8F97_RS17670	COG4104	PAAR repeat-containing protein
A8F97_RS17690	COG3501	Rhs element vgr protein
A8F97_RS17695	COG0205	6-phosphofructokinase activity
A8F97_RS17700	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A8F97_RS17705	COG2814	Major facilitator Superfamily
A8F97_RS17715	COG3552	Protein containing von Willebrand factor type A (VWA) domain
A8F97_RS17720	COG2425	protein containing a von Willebrand factor type A (vWA) domain
A8F97_RS17725	COG0714	Associated with various cellular activities
A8F97_RS17730	COG3831	ATPase activity
A8F97_RS17735	COG3678	ATP-independent chaperone mediated protein folding
A8F97_RS17740	COG0745	RESPONSE REGULATOR receiver
A8F97_RS17745	COG2205	protein histidine kinase activity
A8F97_RS17760	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
A8F97_RS17775	COG0584	glycerophosphoryl diester phosphodiesterase
A8F97_RS17780	COG3842	ATPase activity
A8F97_RS17785	COG0395	ABC-type sugar transport system, permease component
A8F97_RS17790	COG1175	transmembrane transport
A8F97_RS17795	COG1653	transport
A8F97_RS17800	COG3609	addiction module antidote protein, CC2985 family
A8F97_RS17815	COG1349	DNA-binding transcription factor activity
A8F97_RS17820	COG2084	Dehydrogenase
A8F97_RS17825	COG3395	kinase activity
A8F97_RS17830	COG0235	Class ii aldolase
A8F97_RS17835	COG3622	Belongs to the hyi family
A8F97_RS17840	COG2610	gluconate transmembrane transporter activity
A8F97_RS17845	COG0840	transmembrane signaling receptor activity
A8F97_RS17850	COG0840	transmembrane signaling receptor activity
A8F97_RS17855	COG0840	transmembrane signaling receptor activity
A8F97_RS17860	COG0840	transmembrane signaling receptor activity
A8F97_RS17865	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A8F97_RS17870	COG0410	ABC transporter
A8F97_RS17875	COG0411	ABC transporter
A8F97_RS17880	COG4177	L-phenylalanine transmembrane transporter activity
A8F97_RS17885	COG0559	Belongs to the binding-protein-dependent transport system permease family
A8F97_RS17890	COG0683	leucine binding
A8F97_RS17905	COG2177	Part of the ABC transporter FtsEX involved in
A8F97_RS17910	COG2884	Cell division ATP-binding protein ftsE
A8F97_RS17915	COG0552	protein localization to endoplasmic reticulum
A8F97_RS17915	COG0552	protein localization to endoplasmic reticulum
A8F97_RS17920	COG0742	ribosomal rna small subunit methyltransferase
A8F97_RS17925	COG3776	membrane
A8F97_RS17935	COG3714	YhhN family
A8F97_RS17945	COG0425	Belongs to the sulfur carrier protein TusA family
A8F97_RS17950	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
A8F97_RS17960	COG0477	Major facilitator Superfamily
A8F97_RS17965	COG1295	ribonuclease BN
A8F97_RS17970	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A8F97_RS17975	COG0612	Peptidase, M16
A8F97_RS17980	COG1301	dicarboxylic acid transport
A8F97_RS17985	COG2200	EAL domain
A8F97_RS17985	COG2199	diguanylate cyclase activity
A8F97_RS17990	COG2194	sulfuric ester hydrolase activity
A8F97_RS18015	COG1215	transferase activity, transferring glycosyl groups
A8F97_RS18020	COG1215	transferase activity, transferring glycosyl groups
A8F97_RS18025	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
A8F97_RS18030	COG0457	Tetratricopeptide repeat
A8F97_RS18030	COG3118	belongs to the thioredoxin family
A8F97_RS18045	COG2271	Major facilitator Superfamily
A8F97_RS18050	COG1802	Transcriptional regulator
A8F97_RS18055	COG1063	alcohol dehydrogenase
A8F97_RS18070	COG3977	Valine--pyruvate aminotransferase
A8F97_RS18115	COG4608	Belongs to the ABC transporter superfamily
A8F97_RS18120	COG0444	Belongs to the ABC transporter superfamily
A8F97_RS18125	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A8F97_RS18130	COG0601	transmembrane transport
A8F97_RS18135	COG0747	negative chemotaxis
A8F97_RS18145	COG3493	citrate carrier protein
A8F97_RS18160	COG4565	transcriptional regulatory protein
A8F97_RS18165	COG3290	protein histidine kinase activity
A8F97_RS18170	COG0471	metal ion transport
A8F97_RS18175	COG2985	domain, Protein
A8F97_RS18175	COG0569	domain protein
A8F97_RS18185	COG0071	Belongs to the small heat shock protein (HSP20) family
A8F97_RS18190	COG0071	Belongs to the small heat shock protein (HSP20) family
A8F97_RS18195	COG5645	(Lipo)protein
A8F97_RS18200	COG0823	Involved in the tonB-independent uptake of proteins
A8F97_RS18210	COG2723	6-phospho-beta-galactosidase activity
A8F97_RS18215	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A8F97_RS18215	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A8F97_RS18220	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A8F97_RS18225	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A8F97_RS18230	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A8F97_RS18235	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A8F97_RS18240	COG1116	anion transmembrane transporter activity
A8F97_RS18250	COG2271	Major facilitator Superfamily
A8F97_RS18255	COG4948	Mandelate Racemase Muconate Lactonizing
A8F97_RS18260	COG0800	Aldolase
A8F97_RS18265	COG3734	2-keto-3-deoxy-galactonokinase
A8F97_RS18270	COG2186	Transcriptional regulator
A8F97_RS18280	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A8F97_RS18285	COG0601	transmembrane transport
A8F97_RS18300	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A8F97_RS18305	COG0747	negative chemotaxis
A8F97_RS18320	COG0561	phosphatase activity
A8F97_RS18325	COG2723	6-phospho-beta-galactosidase activity
A8F97_RS18330	COG1447	Phosphotransferase system cellobiose-specific component IIA
A8F97_RS18335	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A8F97_RS18345	COG1609	Transcriptional regulator
A8F97_RS18350	COG0840	transmembrane signaling receptor activity
A8F97_RS18365	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A8F97_RS18370	COG0592	DNA-directed DNA polymerase activity
A8F97_RS18375	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A8F97_RS18385	COG0706	membrane insertase activity
A8F97_RS18390	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A8F97_RS18400	COG1396	sequence-specific DNA binding
A8F97_RS18410	COG0702	epimerase
A8F97_RS18415	COG1733	regulation of RNA biosynthetic process
A8F97_RS18425	COG1215	transferase activity, transferring glycosyl groups
A8F97_RS18430	COG0726	polysaccharide deacetylase
A8F97_RS18430	COG1649	PFAM Uncharacterised BCR, COG1649
A8F97_RS18435	COG0457	Tetratricopeptide repeat
A8F97_RS18445	COG2199	diguanylate cyclase activity
A8F97_RS18470	COG0493	'glutamate synthase
A8F97_RS18470	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
A8F97_RS18475	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
A8F97_RS18480	COG2091	lysine biosynthetic process via aminoadipic acid
A8F97_RS18485	COG2252	PERMEase
A8F97_RS18490	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A8F97_RS18495	COG0765	amino acid transport
A8F97_RS18500	COG0765	amino acid transport
A8F97_RS18505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A8F97_RS18510	COG3135	benzoate transporter
A8F97_RS18515	COG1396	sequence-specific DNA binding
A8F97_RS18525	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A8F97_RS18530	COG0581	inorganic phosphate transmembrane transporter activity
A8F97_RS18535	COG0573	inorganic phosphate transmembrane transporter activity
A8F97_RS18540	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A8F97_RS18555	COG1028	Short-chain dehydrogenase reductase Sdr
A8F97_RS18565	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A8F97_RS18590	COG1216	Glycosyl transferase, family 2
A8F97_RS18595	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A8F97_RS18600	COG0318	PFAM AMP-dependent synthetase and ligase
A8F97_RS18610	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A8F97_RS18615	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A8F97_RS18640	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A8F97_RS18645	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A8F97_RS18655	COG0402	S-adenosylhomocysteine deaminase activity
A8F97_RS18660	COG2188	Transcriptional regulator
A8F97_RS18670	COG2986	histidine ammonia-lyase
A8F97_RS18685	COG1174	glycine betaine transport
A8F97_RS18710	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A8F97_RS18715	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A8F97_RS18720	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A8F97_RS18725	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A8F97_RS18730	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A8F97_RS18735	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A8F97_RS18745	COG0356	it plays a direct role in the translocation of protons across the membrane
A8F97_RS18750	COG3312	ion transport
A8F97_RS18755	COG0357	Ribosomal RNA small subunit methyltransferase G
A8F97_RS18760	COG0445	tRNA wobble uridine modification
A8F97_RS18765	COG0716	FMN binding
A8F97_RS18770	COG1522	sequence-specific DNA binding
A8F97_RS18775	COG2502	aspartate--ammonia ligase
A8F97_RS18780	COG2425	protein containing a von Willebrand factor type A (vWA) domain
A8F97_RS18785	COG0714	Associated with various cellular activities
A8F97_RS18790	COG3158	transport of potassium into the cell
A8F97_RS18795	COG0642	Histidine kinase
A8F97_RS18805	COG3111	PFAM Bacterial OB fold (BOF) protein
A8F97_RS18810	COG1869	D-ribose catabolic process
A8F97_RS18815	COG1129	ABC transporter
A8F97_RS18820	COG1172	Belongs to the binding-protein-dependent transport system permease family
A8F97_RS18830	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A8F97_RS18835	COG1609	Transcriptional regulator
A8F97_RS18865	COG1763	Mo-molybdopterin cofactor biosynthetic process
A8F97_RS18870	COG0746	molybdenum cofactor guanylyltransferase activity
A8F97_RS18875	COG3084	Protein conserved in bacteria
A8F97_RS18880	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
A8F97_RS18890	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A8F97_RS18890	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A8F97_RS18895	COG0218	Necessary for normal cell division and for the maintenance of normal septation
A8F97_RS18900	COG3078	GTPase activator activity
A8F97_RS18905	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A8F97_RS18910	COG2801	Transposase and inactivated derivatives
A8F97_RS18915	COG2963	transposase activity
A8F97_RS18945	COG3852	Histidine kinase
A8F97_RS18960	COG1011	Hydrolase
A8F97_RS18965	COG1490	D-aminoacyl-tRNA deacylase activity
A8F97_RS18970	COG0456	acetyltransferase
A8F97_RS18975	COG2982	Protein involved in outer membrane biogenesis
A8F97_RS18980	COG2233	PERMEase
A8F97_RS18985	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A8F97_RS18990	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A8F97_RS18995	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A8F97_RS19000	COG1758	RNA polymerase activity
A8F97_RS19005	COG0194	GDP metabolic process
A8F97_RS19010	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A8F97_RS19015	COG2194	sulfuric ester hydrolase activity
A8F97_RS19030	COG2200	EAL domain
A8F97_RS19035	COG2081	HI0933 family
A8F97_RS19040	COG0306	phosphate transporter
A8F97_RS19050	COG0589	response to stress
A8F97_RS19055	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A8F97_RS19065	COG0737	Belongs to the 5'-nucleotidase family
A8F97_RS19070	COG0742	ribosomal rna small subunit methyltransferase
A8F97_RS19095	COG0443	Heat shock 70 kDa protein
A8F97_RS19100	COG2214	Heat shock protein DnaJ domain protein
A8F97_RS19110	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
A8F97_RS19115	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A8F97_RS19145	COG1280	lysine exporter protein (LysE YggA)
A8F97_RS19150	COG0583	DNA-binding transcription factor activity
A8F97_RS19155	COG3479	Phenolic acid decarboxylase
A8F97_RS19170	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A8F97_RS19175	COG4172	Belongs to the ABC transporter superfamily
A8F97_RS19180	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A8F97_RS19190	COG4166	transmembrane transport
A8F97_RS19195	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A8F97_RS19200	COG0840	transmembrane signaling receptor activity
A8F97_RS19205	COG0456	acetyltransferase
A8F97_RS19210	COG2818	Glycosylase
A8F97_RS19215	COG0730	response to heat
A8F97_RS19220	COG0752	glycyl-tRNA synthetase alpha subunit
A8F97_RS19225	COG0751	glycine-tRNA ligase activity
A8F97_RS19235	COG2213	PTS system mannitol-specific
A8F97_RS19235	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
A8F97_RS19240	COG0246	Mannitol dehydrogenase
A8F97_RS19245	COG3722	fumarate hydratase activity
A8F97_RS19255	COG0840	transmembrane signaling receptor activity
A8F97_RS19260	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A8F97_RS19265	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
A8F97_RS19270	COG1012	belongs to the aldehyde dehydrogenase family
A8F97_RS19275	COG3274	enterobacterial common antigen metabolic process
A8F97_RS19280	COG1070	Carbohydrate kinase
A8F97_RS19285	COG2115	Belongs to the xylose isomerase family
A8F97_RS19290	COG4213	ABC transporter substrate-binding protein
A8F97_RS19295	COG1129	ABC transporter
A8F97_RS19300	COG4214	carbohydrate transport
A8F97_RS19305	COG2207	Transcriptional regulator
A8F97_RS19305	COG1609	Transcriptional regulator
A8F97_RS19315	COG0137	argininosuccinate synthase activity
A8F97_RS19325	COG2771	luxR family
A8F97_RS19330	COG4677	pectinesterase activity
A8F97_RS19335	COG3136	membrane protein required for alginate biosynthesis
A8F97_RS19340	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A8F97_RS19345	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A8F97_RS19375	COG3239	Fatty acid desaturase
A8F97_RS19385	COG1012	belongs to the aldehyde dehydrogenase family
A8F97_RS19390	COG1304	FMN binding
A8F97_RS19395	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
A8F97_RS19395	COG0456	acetyltransferase
A8F97_RS19400	COG0628	permease
A8F97_RS19430	COG1561	YicC-like family, N-terminal region
A8F97_RS19435	COG0583	DNA-binding transcription factor activity
A8F97_RS19440	COG1446	asparaginase
A8F97_RS19455	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A8F97_RS19460	COG0601	transmembrane transport
A8F97_RS19465	COG0747	negative chemotaxis
A8F97_RS19470	COG4172	Belongs to the ABC transporter superfamily
A8F97_RS19475	COG4948	Mandelate Racemase Muconate Lactonizing
A8F97_RS19480	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
A8F97_RS19485	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A8F97_RS19490	COG1309	transcriptional regulator
A8F97_RS19495	COG0756	dUTP diphosphatase activity
A8F97_RS19500	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A8F97_RS19505	COG2003	Belongs to the UPF0758 family
A8F97_RS19510	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A8F97_RS19520	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A8F97_RS19525	COG1442	glycosyl transferase family 8
A8F97_RS19525	COG1216	Glycosyl transferase, family 2
A8F97_RS19530	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A8F97_RS19535	COG1519	Transferase
A8F97_RS19550	COG2089	acid synthase
A8F97_RS19555	COG1218	3'(2'),5'-bisphosphate nucleotidase
A8F97_RS19560	COG0110	maltose O-acetyltransferase activity
A8F97_RS19565	COG0438	transferase activity, transferring glycosyl groups
A8F97_RS19565	COG4641	Protein conserved in bacteria
A8F97_RS19570	COG1442	glycosyl transferase family 8
A8F97_RS19580	COG0438	transferase activity, transferring glycosyl groups
A8F97_RS19585	COG0515	serine threonine protein kinase
A8F97_RS19590	COG0438	transferase activity, transferring glycosyl groups
A8F97_RS19595	COG0859	PFAM glycosyl transferase family 9
A8F97_RS19600	COG3307	-O-antigen
A8F97_RS19605	COG0859	PFAM glycosyl transferase family 9
A8F97_RS19615	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A8F97_RS19620	COG0156	8-amino-7-oxononanoate synthase activity
A8F97_RS19625	COG1063	alcohol dehydrogenase
A8F97_RS19630	COG2861	carbohydrate metabolic process
A8F97_RS19635	COG4942	peptidase
A8F97_RS19640	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A8F97_RS19645	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
A8F97_RS19650	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A8F97_RS19655	COG1045	serine acetyltransferase
A8F97_RS19680	COG0583	DNA-binding transcription factor activity
A8F97_RS19685	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A8F97_RS19690	COG0840	transmembrane signaling receptor activity
A8F97_RS19695	COG0840	transmembrane signaling receptor activity
A8F97_RS19700	COG0412	Dienelactone hydrolase
A8F97_RS19715	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
A8F97_RS19795	COG1116	anion transmembrane transporter activity
A8F97_RS19800	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A8F97_RS19840	COG0583	DNA-binding transcription factor activity
A8F97_RS19935	COG3209	COG3209 Rhs family protein
A8F97_RS19950	COG3209	COG3209 Rhs family protein
A8F97_RS19955	COG3209	COG3209 Rhs family protein
A8F97_RS19990	COG3209	COG3209 Rhs family protein
A8F97_RS20035	COG3209	COG3209 Rhs family protein
A8F97_RS20055	COG3209	COG3209 Rhs family protein
A8F97_RS20065	COG3209	COG3209 Rhs family protein
A8F97_RS20075	COG3209	COG3209 Rhs family protein
A8F97_RS20080	COG4974	Belongs to the 'phage' integrase family
A8F97_RS20085	COG0358	DNA primase activity
A8F97_RS20090	COG3620	sequence-specific DNA binding
A8F97_RS20115	COG4974	Belongs to the 'phage' integrase family
A8F97_RS20120	COG0358	DNA primase activity
A8F97_RS20125	COG3620	sequence-specific DNA binding
A8F97_RS20140	COG3209	COG3209 Rhs family protein
A8F97_RS20180	COG3501	Rhs element vgr protein
A8F97_RS20190	COG1263	PTS System
A8F97_RS20190	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A8F97_RS20190	COG2190	(PTS) system
A8F97_RS20195	COG4948	Mandelate Racemase Muconate Lactonizing
A8F97_RS20200	COG2188	Transcriptional regulator
A8F97_RS20205	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A8F97_RS20210	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A8F97_RS20215	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A8F97_RS20220	COG0165	Argininosuccinate lyase
A8F97_RS20225	COG1322	Protein conserved in bacteria
A8F97_RS20230	COG2226	methyltransferase
A8F97_RS20240	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
A8F97_RS20245	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A8F97_RS20250	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A8F97_RS20255	COG0805	protein transport
A8F97_RS20260	COG0084	hydrolase, TatD family'
A8F97_RS20270	COG0250	Participates in transcription elongation, termination and antitermination
A8F97_RS20275	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
A8F97_RS20290	COG0183	Belongs to the thiolase family
A8F97_RS20295	COG1250	3-hydroxyacyl-CoA dehydrogenase
A8F97_RS20295	COG1024	Enoyl-CoA hydratase
A8F97_RS20300	COG0006	proline dipeptidase activity
A8F97_RS20305	COG1739	Uncharacterized protein family UPF0029
A8F97_RS20355	COG1879	ABC-type sugar transport system periplasmic component
A8F97_RS20360	COG1129	ABC transporter
A8F97_RS20365	COG1172	Belongs to the binding-protein-dependent transport system permease family
A8F97_RS20370	COG1172	Belongs to the binding-protein-dependent transport system permease family
A8F97_RS20375	COG0583	DNA-binding transcription factor activity
A8F97_RS20380	COG3085	chromosome segregation
A8F97_RS20395	COG3978	acetolactate synthase activity
A8F97_RS20400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A8F97_RS20405	COG0129	dihydroxy-acid dehydratase activity
A8F97_RS20425	COG0583	DNA-binding transcription factor activity
A8F97_RS20430	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A8F97_RS20440	COG0583	DNA-binding transcription factor activity
A8F97_RS20450	COG0506	proline dehydrogenase activity
A8F97_RS20450	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
A8F97_RS20450	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
A8F97_RS20455	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A8F97_RS20465	COG0248	Ppx GppA phosphatase
A8F97_RS20470	COG0513	Belongs to the DEAD box helicase family
A8F97_RS20475	COG3118	belongs to the thioredoxin family
A8F97_RS20480	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A8F97_RS20485	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A8F97_RS20490	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
A8F97_RS20495	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
A8F97_RS20500	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
A8F97_RS20505	COG1088	dTDP-glucose 4,6-dehydratase activity
A8F97_RS20510	COG0456	acetyltransferase
A8F97_RS20515	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A8F97_RS20520	COG2244	polysaccharide biosynthetic process
A8F97_RS20525	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A8F97_RS20535	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
A8F97_RS20565	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A8F97_RS20580	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A8F97_RS20585	COG0456	acetyltransferase
A8F97_RS20590	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A8F97_RS20595	COG0765	amino acid transport
A8F97_RS20600	COG1126	abc transporter atp-binding protein
A8F97_RS20605	COG1473	amidohydrolase
A8F97_RS20610	COG1126	abc transporter atp-binding protein
A8F97_RS20615	COG0765	amino acid transport
A8F97_RS20620	COG4597	amino acid ABC transporter
A8F97_RS20625	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A8F97_RS20645	COG1802	Transcriptional regulator
A8F97_RS20650	COG3071	HemY protein
A8F97_RS20655	COG2959	enzyme of heme biosynthesis
A8F97_RS20660	COG1587	Uroporphyrinogen-III synthase
A8F97_RS20665	COG0181	hydroxymethylbilane synthase activity
A8F97_RS20680	COG1965	Belongs to the frataxin family
A8F97_RS20685	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A8F97_RS20700	COG1011	Hydrolase
A8F97_RS20705	COG0210	DNA helicase
A8F97_RS20715	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
A8F97_RS20720	COG0598	Magnesium transport protein CorA
A8F97_RS20725	COG3180	Ammonia monooxygenase
A8F97_RS20735	COG2050	protein possibly involved in aromatic compounds catabolism
A8F97_RS20745	COG0514	ATP-dependent DNA helicase (RecQ)
A8F97_RS20750	COG1280	lysine exporter protein (LysE YggA)
A8F97_RS20755	COG1280	lysine exporter protein (LysE YggA)
A8F97_RS20760	COG2267	carboxylic ester hydrolase activity
A8F97_RS20765	COG0561	phosphatase activity
A8F97_RS20770	COG2271	Major facilitator Superfamily
A8F97_RS20775	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A8F97_RS20780	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
A8F97_RS20785	COG0247	lactate metabolic process
A8F97_RS20795	COG1741	Belongs to the pirin family
A8F97_RS20800	COG1472	Belongs to the glycosyl hydrolase 3 family
A8F97_RS20805	COG2095	MarC family integral membrane protein
A8F97_RS20810	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A8F97_RS20820	COG3275	phosphorelay sensor kinase activity
A8F97_RS20825	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
A8F97_RS20830	COG1523	belongs to the glycosyl hydrolase 13 family
A8F97_RS20835	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
A8F97_RS20840	COG0297	glycogen (starch) synthase activity
A8F97_RS20845	COG0058	SHG alpha-glucan phosphorylase activity
A8F97_RS20855	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A8F97_RS20860	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A8F97_RS20865	COG2271	Major facilitator Superfamily
A8F97_RS20870	COG2731	YhcH YjgK YiaL family protein
A8F97_RS20875	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A8F97_RS20880	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A8F97_RS20885	COG0705	Rhomboid family
A8F97_RS20890	COG1349	DNA-binding transcription factor activity
A8F97_RS20895	COG0058	SHG alpha-glucan phosphorylase activity
A8F97_RS20900	COG1640	4-alpha-glucanotransferase
A8F97_RS20905	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
A8F97_RS20905	COG0316	Belongs to the HesB IscA family
A8F97_RS20910	COG1040	competence protein
A8F97_RS20915	COG2267	carboxylic ester hydrolase activity
A8F97_RS20920	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A8F97_RS20930	COG1785	Belongs to the alkaline phosphatase family
A8F97_RS20975	COG1414	Transcriptional regulator
A8F97_RS20980	COG2183	response to ionizing radiation
A8F97_RS20990	COG4869	propanediol catabolic process
A8F97_RS21000	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
A8F97_RS21010	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A8F97_RS21025	COG1012	belongs to the aldehyde dehydrogenase family
A8F97_RS21035	COG0693	protein deglycase activity
A8F97_RS21040	COG1882	Formate acetyltransferase
A8F97_RS21045	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A8F97_RS21055	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
A8F97_RS21060	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A8F97_RS21065	COG2207	Transcriptional regulator
A8F97_RS21065	COG1917	Cupin 2, conserved barrel domain protein
A8F97_RS21070	COG2972	Histidine kinase
A8F97_RS21080	COG0840	transmembrane signaling receptor activity
A8F97_RS21090	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A8F97_RS21105	COG4774	siderophore transport
A8F97_RS21110	COG2814	Major facilitator Superfamily
A8F97_RS21130	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
A8F97_RS21135	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
A8F97_RS21140	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
A8F97_RS21145	COG1011	Hydrolase
A8F97_RS21155	COG0494	nUDIX hydrolase
A8F97_RS21160	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
A8F97_RS21185	COG4796	Type ii and iii secretion system protein
A8F97_RS21190	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A8F97_RS21195	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A8F97_RS21210	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A8F97_RS21215	COG0546	phosphoglycolate phosphatase activity
A8F97_RS21225	COG1473	amidohydrolase
A8F97_RS21250	COG1648	precorrin-2 dehydrogenase activity
A8F97_RS21250	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A8F97_RS21260	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A8F97_RS21265	COG4948	Mandelate Racemase Muconate Lactonizing
A8F97_RS21270	COG0747	negative chemotaxis
A8F97_RS21275	COG0601	transmembrane transport
A8F97_RS21280	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A8F97_RS21285	COG0444	Belongs to the ABC transporter superfamily
A8F97_RS21290	COG4608	Belongs to the ABC transporter superfamily
A8F97_RS21295	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A8F97_RS21310	COG3866	Pectate lyase
A8F97_RS21320	COG1280	lysine exporter protein (LysE YggA)
A8F97_RS21345	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A8F97_RS21350	COG1765	OsmC-like protein
A8F97_RS21355	COG3954	Phosphoribulokinase
A8F97_RS21360	COG3089	Belongs to the UPF0270 family
A8F97_RS21365	COG0429	hydrolase of the alpha beta-hydrolase fold
A8F97_RS21375	COG0488	(ABC) transporter
A8F97_RS21380	COG2249	NAD(P)H dehydrogenase (quinone) activity
A8F97_RS21385	COG0475	glutathione-regulated potassium exporter activity
A8F97_RS21385	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A8F97_RS21390	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
A8F97_RS21395	COG1047	Peptidyl-prolyl cis-trans
A8F97_RS21400	COG2900	Belongs to the SlyX family
A8F97_RS21405	COG0545	Peptidyl-prolyl cis-trans isomerase
A8F97_RS21420	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A8F97_RS21425	COG0642	Histidine kinase
A8F97_RS21430	COG0745	RESPONSE REGULATOR receiver
A8F97_RS21435	COG2194	sulfuric ester hydrolase activity
A8F97_RS21440	COG2964	Protein conserved in bacteria
A8F97_RS21445	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
A8F97_RS21450	COG2923	Belongs to the DsrF TusC family
A8F97_RS21455	COG2168	tRNA wobble position uridine thiolation
A8F97_RS21460	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A8F97_RS21465	COG0049	tRNA binding
A8F97_RS21470	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A8F97_RS21475	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A8F97_RS21485	COG2193	ferroxidase activity
A8F97_RS21490	COG0051	transcription antitermination factor activity, RNA binding
A8F97_RS21495	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A8F97_RS21500	COG0088	Forms part of the polypeptide exit tunnel
A8F97_RS21510	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A8F97_RS21515	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A8F97_RS21520	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A8F97_RS21525	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A8F97_RS21530	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A8F97_RS21535	COG0255	Belongs to the universal ribosomal protein uL29 family
A8F97_RS21540	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A8F97_RS21550	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A8F97_RS21555	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A8F97_RS21560	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A8F97_RS21565	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A8F97_RS21570	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A8F97_RS21575	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A8F97_RS21580	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A8F97_RS21585	COG1841	ribosomal large subunit assembly
A8F97_RS21590	COG0200	Binds to the 23S rRNA
A8F97_RS21595	COG0201	protein transport
A8F97_RS21600	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A8F97_RS21605	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A8F97_RS21615	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A8F97_RS21620	COG0202	RNA polymerase activity
A8F97_RS21625	COG0203	ribosomal protein L17
A8F97_RS21630	COG3036	rescue of stalled ribosome
A8F97_RS21635	COG1970	mechanosensitive ion channel activity
A8F97_RS21640	COG0569	domain protein
A8F97_RS21645	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A8F97_RS21645	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A8F97_RS21650	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A8F97_RS21655	COG0242	peptide deformylase activity
A8F97_RS21660	COG0758	DNA mediated transformation
A8F97_RS21665	COG2922	Belongs to the Smg family
A8F97_RS21670	COG0551	DNA topoisomerase type I activity
A8F97_RS21675	COG0009	L-threonylcarbamoyladenylate synthase
A8F97_RS21680	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A8F97_RS21690	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
A8F97_RS21720	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
A8F97_RS21725	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
A8F97_RS21735	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
A8F97_RS21740	COG4589	Belongs to the CDS family
A8F97_RS21755	COG1414	Transcriptional regulator
A8F97_RS21760	COG1410	methionine synthase
A8F97_RS21760	COG0646	methionine synthase
A8F97_RS21770	COG0471	metal ion transport
A8F97_RS21780	COG0527	aspartate kinase activity
A8F97_RS21785	COG0166	Belongs to the GPI family
A8F97_RS21795	COG1509	lysine 2,3-aminomutase activity
A8F97_RS21800	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A8F97_RS21815	COG3040	lipid binding
A8F97_RS21820	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
A8F97_RS21825	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
A8F97_RS21830	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A8F97_RS21835	COG1053	succinate dehydrogenase
A8F97_RS21840	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
A8F97_RS21845	COG1511	domain protein
A8F97_RS21845	COG3264	Mechanosensitive ion channel
A8F97_RS21850	COG0688	phosphatidylethanolamine metabolic process
A8F97_RS21855	COG1162	GTPase activity
A8F97_RS21860	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
A8F97_RS21885	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
A8F97_RS21900	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A8F97_RS21905	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
A8F97_RS21905	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A8F97_RS21910	COG0802	atpase or kinase
A8F97_RS21915	COG0860	N-Acetylmuramoyl-L-alanine amidase
A8F97_RS21920	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
A8F97_RS21925	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A8F97_RS21930	COG1923	regulation of RNA biosynthetic process
A8F97_RS21935	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A8F97_RS21940	COG0330	HflC and HflK could
A8F97_RS21945	COG0330	HflC and HflK could
A8F97_RS21950	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
A8F97_RS21955	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A8F97_RS21960	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A8F97_RS21965	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
A8F97_RS21970	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A8F97_RS21975	COG1678	Uncharacterized ACR, COG1678
A8F97_RS21980	COG0189	ligase activity
A8F97_RS21985	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A8F97_RS21990	COG2356	endonuclease I
A8F97_RS21995	COG3091	SprT-like family
A8F97_RS22000	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A8F97_RS22005	COG1166	arginine decarboxylase activity
A8F97_RS22015	COG0501	Belongs to the peptidase M48B family
A8F97_RS22020	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A8F97_RS22025	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A8F97_RS22030	COG0126	phosphoglycerate kinase activity
A8F97_RS22035	COG0191	fructose-bisphosphate aldolase activity
A8F97_RS22040	COG0668	transmembrane transport
A8F97_RS22045	COG0235	Class ii aldolase
A8F97_RS22050	COG3623	hexulose-6-phosphate isomerase
A8F97_RS22055	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
A8F97_RS22060	COG1070	Carbohydrate kinase
A8F97_RS22070	COG2731	YhcH YjgK YiaL family protein
A8F97_RS22090	COG1172	Belongs to the binding-protein-dependent transport system permease family
A8F97_RS22095	COG1129	ABC transporter
A8F97_RS22100	COG1414	Transcriptional regulator
A8F97_RS22105	COG1279	arginine transmembrane transporter activity
A8F97_RS22125	COG0583	DNA-binding transcription factor activity
A8F97_RS22130	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
A8F97_RS22135	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A8F97_RS22140	COG0604	alcohol dehydrogenase
A8F97_RS22145	COG0840	transmembrane signaling receptor activity
A8F97_RS22150	COG0488	(ABC) transporter
A8F97_RS22155	COG0741	lytic transglycosylase activity
A8F97_RS22160	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
A8F97_RS22165	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
A8F97_RS22175	COG2207	Transcriptional regulator
A8F97_RS22175	COG3708	Transcriptional regulator
A8F97_RS22180	COG3045	CreA protein
A8F97_RS22185	COG0745	RESPONSE REGULATOR receiver
A8F97_RS22190	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
A8F97_RS22200	COG0083	homoserine kinase activity
A8F97_RS22210	COG3022	response to hydroperoxide
A8F97_RS22215	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A8F97_RS22225	COG0521	Mo-molybdopterin cofactor biosynthetic process
A8F97_RS22235	COG1584	GPR1 FUN34 yaaH family protein
A8F97_RS22240	COG0443	Heat shock 70 kDa protein
A8F97_RS22245	COG0484	heat shock protein binding
A8F97_RS22250	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A8F97_RS22255	COG0583	DNA-binding transcription factor activity
A8F97_RS22260	COG0268	Binds directly to 16S ribosomal RNA
A8F97_RS22265	COG0196	riboflavin kinase activity
A8F97_RS22270	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A8F97_RS22280	COG1047	Peptidyl-prolyl cis-trans
A8F97_RS22285	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
A8F97_RS22290	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A8F97_RS22295	COG0505	Belongs to the CarA family
A8F97_RS22300	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A8F97_RS22310	COG2966	Psort location CytoplasmicMembrane, score
A8F97_RS22315	COG3610	response to peptide
A8F97_RS22320	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
A8F97_RS22330	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A8F97_RS22335	COG2967	ApaG domain
A8F97_RS22340	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A8F97_RS22345	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
A8F97_RS22350	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A8F97_RS22355	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
A8F97_RS22360	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
A8F97_RS22365	COG0564	pseudouridine synthase activity
A8F97_RS22410	COG2963	transposase activity
A8F97_RS22415	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A8F97_RS22420	COG0417	DNA replication proofreading
A8F97_RS22445	COG0586	Pfam SNARE associated Golgi protein
A8F97_RS22450	COG0440	acetolactate synthase activity
A8F97_RS22455	COG0028	Belongs to the TPP enzyme family
A8F97_RS22465	COG3507	Belongs to the glycosyl hydrolase 43 family
A8F97_RS22470	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
A8F97_RS22475	COG1178	ABC-type Fe3 transport system permease component
A8F97_RS22480	COG4143	(ABC) transporter
A8F97_RS22495	COG4533	DNA binding
A8F97_RS22510	COG0840	transmembrane signaling receptor activity
A8F97_RS22530	COG0066	3-isopropylmalate dehydratase activity
A8F97_RS22535	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A8F97_RS22540	COG0473	3-isopropylmalate dehydrogenase activity
A8F97_RS22545	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A8F97_RS22550	COG1022	Amp-dependent synthetase and ligase
A8F97_RS22555	COG0028	Belongs to the TPP enzyme family
A8F97_RS22575	COG2001	Belongs to the MraZ family
A8F97_RS22580	COG0275	rRNA processing
A8F97_RS22585	COG3116	cell division
A8F97_RS22590	COG0768	penicillin binding
A8F97_RS22595	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A8F97_RS22600	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A8F97_RS22605	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A8F97_RS22610	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A8F97_RS22615	COG0772	Belongs to the SEDS family
A8F97_RS22620	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A8F97_RS22625	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A8F97_RS22630	COG1181	Belongs to the D-alanine--D-alanine ligase family
A8F97_RS22635	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
A8F97_RS22640	COG0849	cell division
A8F97_RS22645	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A8F97_RS22650	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
A8F97_RS22665	COG0653	protein targeting
A8F97_RS22670	COG0494	nUDIX hydrolase
A8F97_RS22675	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
A8F97_RS22680	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
A8F97_RS22685	COG0237	dephospho-CoA kinase activity
A8F97_RS22690	COG0516	GMP reductase activity
A8F97_RS22695	COG1459	type II secretion system
A8F97_RS22700	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A8F97_RS22705	COG4969	Belongs to the N-Me-Phe pilin family
A8F97_RS22710	COG0157	Belongs to the NadC ModD family
A8F97_RS22715	COG3248	Nucleoside-binding outer membrane protein
A8F97_RS22720	COG3023	N-Acetylmuramoyl-L-alanine amidase
A8F97_RS22725	COG3725	Membrane protein required for beta-lactamase induction
A8F97_RS22730	COG1113	amino acid transport
A8F97_RS22740	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
A8F97_RS22745	COG0508	dehydrogenase complex catalyzes the overall conversion of
A8F97_RS22750	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A8F97_RS22755	COG0583	DNA-binding transcription factor activity
A8F97_RS22785	COG2079	MmgE PrpD family protein
A8F97_RS22790	COG2207	Transcriptional regulator
A8F97_RS22795	COG4771	TonB-dependent receptor
A8F97_RS22820	COG3433	isochorismatase activity
A8F97_RS22820	COG1535	isochorismatase
A8F97_RS22825	COG4774	siderophore transport
A8F97_RS22830	COG2382	esterase