locus-tag	class	description
F131LOC_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
F131LOC_RS00010	COG0592	DNA-directed DNA polymerase activity
F131LOC_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
F131LOC_RS00030	COG0840	transmembrane signaling receptor activity
F131LOC_RS00035	COG1609	Transcriptional regulator
F131LOC_RS00040	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
F131LOC_RS00045	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
F131LOC_RS00050	COG1447	Phosphotransferase system cellobiose-specific component IIA
F131LOC_RS00055	COG2723	6-phospho-beta-galactosidase activity
F131LOC_RS00060	COG0561	phosphatase activity
F131LOC_RS00110	COG3501	Rhs element vgr protein
F131LOC_RS00120	COG3977	Valine--pyruvate aminotransferase
F131LOC_RS00140	COG1063	alcohol dehydrogenase
F131LOC_RS00150	COG2271	Major facilitator Superfamily
F131LOC_RS00165	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
F131LOC_RS00185	COG3118	belongs to the thioredoxin family
F131LOC_RS00185	COG0457	Tetratricopeptide repeat
F131LOC_RS00190	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
F131LOC_RS00195	COG1215	transferase activity, transferring glycosyl groups
F131LOC_RS00200	COG1215	transferase activity, transferring glycosyl groups
F131LOC_RS00205	COG1192	Involved in chromosome partitioning
F131LOC_RS00225	COG2194	sulfuric ester hydrolase activity
F131LOC_RS00230	COG2199	diguanylate cyclase activity
F131LOC_RS00230	COG2200	EAL domain
F131LOC_RS00235	COG1301	dicarboxylic acid transport
F131LOC_RS00240	COG0612	Peptidase, M16
F131LOC_RS00245	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F131LOC_RS00250	COG1295	ribonuclease BN
F131LOC_RS00255	COG0477	Major facilitator Superfamily
F131LOC_RS00290	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
F131LOC_RS00295	COG0425	Belongs to the sulfur carrier protein TusA family
F131LOC_RS00305	COG3714	YhhN family
F131LOC_RS00320	COG3776	membrane
F131LOC_RS00325	COG0742	ribosomal rna small subunit methyltransferase
F131LOC_RS00330	COG0552	protein localization to endoplasmic reticulum
F131LOC_RS00335	COG2884	Cell division ATP-binding protein ftsE
F131LOC_RS00340	COG2177	Part of the ABC transporter FtsEX involved in
F131LOC_RS00355	COG0683	leucine binding
F131LOC_RS00360	COG0559	Belongs to the binding-protein-dependent transport system permease family
F131LOC_RS00370	COG0411	ABC transporter
F131LOC_RS00375	COG0410	ABC transporter
F131LOC_RS00380	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F131LOC_RS00390	COG0840	transmembrane signaling receptor activity
F131LOC_RS00395	COG0840	transmembrane signaling receptor activity
F131LOC_RS00400	COG0840	transmembrane signaling receptor activity
F131LOC_RS00405	COG2610	gluconate transmembrane transporter activity
F131LOC_RS00410	COG3622	Belongs to the hyi family
F131LOC_RS00415	COG0235	Class ii aldolase
F131LOC_RS00420	COG3395	kinase activity
F131LOC_RS00425	COG2084	Dehydrogenase
F131LOC_RS00430	COG1349	DNA-binding transcription factor activity
F131LOC_RS00465	COG1653	transport
F131LOC_RS00470	COG1175	transmembrane transport
F131LOC_RS00475	COG0395	ABC-type sugar transport system, permease component
F131LOC_RS00480	COG3842	ATPase activity
F131LOC_RS00485	COG0584	glycerophosphoryl diester phosphodiesterase
F131LOC_RS00500	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
F131LOC_RS00515	COG2205	protein histidine kinase activity
F131LOC_RS00520	COG0745	RESPONSE REGULATOR receiver
F131LOC_RS00525	COG3678	ATP-independent chaperone mediated protein folding
F131LOC_RS00540	COG3831	ATPase activity
F131LOC_RS00545	COG0714	Associated with various cellular activities
F131LOC_RS00550	COG2425	protein containing a von Willebrand factor type A (vWA) domain
F131LOC_RS00555	COG3552	Protein containing von Willebrand factor type A (VWA) domain
F131LOC_RS00565	COG2814	Major facilitator Superfamily
F131LOC_RS00570	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
F131LOC_RS00575	COG0205	6-phosphofructokinase activity
F131LOC_RS00580	COG0583	DNA-binding transcription factor activity
F131LOC_RS00620	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F131LOC_RS00625	COG1116	anion transmembrane transporter activity
F131LOC_RS00630	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
F131LOC_RS00635	COG2957	Belongs to the agmatine deiminase family
F131LOC_RS00640	COG0149	triose-phosphate isomerase activity
F131LOC_RS00650	COG3152	Membrane
F131LOC_RS00660	COG1494	fructose-1,6-bisphosphatase
F131LOC_RS00670	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
F131LOC_RS00675	COG3074	FtsZ-dependent cytokinesis
F131LOC_RS00680	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
F131LOC_RS00685	COG1575	Belongs to the MenA family. Type 1 subfamily
F131LOC_RS00690	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
F131LOC_RS00695	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
F131LOC_RS00700	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
F131LOC_RS00705	COG1609	Transcriptional regulator
F131LOC_RS00710	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
F131LOC_RS00715	COG0254	rRNA binding
F131LOC_RS00720	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F131LOC_RS00730	COG1120	ATPase activity
F131LOC_RS00735	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
F131LOC_RS00740	COG0626	cystathionine gamma-synthase activity
F131LOC_RS00745	COG0527	aspartate kinase activity
F131LOC_RS00745	COG0460	homoserine dehydrogenase
F131LOC_RS00750	COG3842	ATPase activity
F131LOC_RS00765	COG0395	ABC-type sugar transport system, permease component
F131LOC_RS00770	COG1609	Transcriptional regulator
F131LOC_RS00775	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
F131LOC_RS00790	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F131LOC_RS00805	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
F131LOC_RS00815	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
F131LOC_RS00845	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
F131LOC_RS00845	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
F131LOC_RS00850	COG1072	(Pantothenic acid kinase))
F131LOC_RS00880	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
F131LOC_RS00890	COG0250	Participates in transcription elongation, termination and antitermination
F131LOC_RS00895	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
F131LOC_RS00900	COG0081	regulation of translation
F131LOC_RS00905	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
F131LOC_RS00910	COG0222	ribosome binding
F131LOC_RS00915	COG0085	RNA polymerase activity
F131LOC_RS00920	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
F131LOC_RS00925	COG0477	Major facilitator Superfamily
F131LOC_RS00930	COG5457	Domain of unknown function (DUF1127)
F131LOC_RS00935	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F131LOC_RS00945	COG2022	thiamine diphosphate biosynthetic process
F131LOC_RS00950	COG2104	thiamine diphosphate biosynthetic process
F131LOC_RS00955	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
F131LOC_RS00960	COG0352	thiamine-phosphate diphosphorylase activity
F131LOC_RS00965	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
F131LOC_RS00970	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
F131LOC_RS00975	COG2816	NAD+ diphosphatase activity
F131LOC_RS00980	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
F131LOC_RS00985	COG1515	deoxyribonuclease V activity
F131LOC_RS01005	COG0151	Belongs to the GarS family
F131LOC_RS01010	COG0138	bifunctional purine biosynthesis protein purh
F131LOC_RS01040	COG1126	abc transporter atp-binding protein
F131LOC_RS01045	COG0765	amino acid transport
F131LOC_RS01050	COG4597	amino acid ABC transporter
F131LOC_RS01055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F131LOC_RS01060	COG0765	amino acid transport
F131LOC_RS01065	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F131LOC_RS01100	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
F131LOC_RS01115	COG2264	protein methyltransferase activity
F131LOC_RS01120	COG4145	pantothenate transmembrane transporter activity
F131LOC_RS01125	COG3924	membrane
F131LOC_RS01135	COG0439	Biotin carboxylase
F131LOC_RS01140	COG0511	ligase activity, forming carbon-carbon bonds
F131LOC_RS01145	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
F131LOC_RS01150	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
F131LOC_RS01155	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
F131LOC_RS01160	COG0604	alcohol dehydrogenase
F131LOC_RS01165	COG2200	EAL domain
F131LOC_RS01165	COG2199	diguanylate cyclase activity
F131LOC_RS01170	COG1077	Cell shape determining protein MreB Mrl
F131LOC_RS01175	COG1792	Involved in formation and maintenance of cell shape
F131LOC_RS01180	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
F131LOC_RS01185	COG0424	maF-like protein
F131LOC_RS01190	COG1530	ribonuclease E activity
F131LOC_RS01195	COG3164	Protein of unknown function
F131LOC_RS01200	COG0312	modulator of DNA gyrase
F131LOC_RS01215	COG0583	DNA-binding transcription factor activity
F131LOC_RS01225	COG1566	PFAM secretion protein HlyD family protein
F131LOC_RS01230	COG1289	transmembrane transporter activity
F131LOC_RS01240	COG3028	Belongs to the UPF0307 family
F131LOC_RS01245	COG0312	modulator of DNA gyrase
F131LOC_RS01250	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
F131LOC_RS01255	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
F131LOC_RS01260	COG1660	Displays ATPase and GTPase activities
F131LOC_RS01265	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
F131LOC_RS01270	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
F131LOC_RS01275	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
F131LOC_RS01280	COG1137	ATPase activity
F131LOC_RS01285	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
F131LOC_RS01290	COG3117	lipopolysaccharide transmembrane transporter activity
F131LOC_RS01295	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
F131LOC_RS01300	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
F131LOC_RS01300	COG0517	IMP dehydrogenase activity
F131LOC_RS01305	COG0530	calcium, potassium:sodium antiporter activity
F131LOC_RS01310	COG1127	ABC transporter
F131LOC_RS01315	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
F131LOC_RS01320	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
F131LOC_RS01325	COG2854	intermembrane phospholipid transfer
F131LOC_RS01330	COG3113	response to antibiotic
F131LOC_RS01335	COG5007	Belongs to the BolA IbaG family
F131LOC_RS01340	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
F131LOC_RS01345	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F131LOC_RS01350	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F131LOC_RS01355	COG3105	Protein conserved in bacteria
F131LOC_RS01360	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
F131LOC_RS01365	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
F131LOC_RS01370	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
F131LOC_RS01375	COG0477	Major facilitator Superfamily
F131LOC_RS01380	COG1063	alcohol dehydrogenase
F131LOC_RS01385	COG1028	Short-chain dehydrogenase reductase Sdr
F131LOC_RS01400	COG0625	glutathione transferase activity
F131LOC_RS01405	COG2969	positive regulation of protein catabolic process
F131LOC_RS01420	COG0493	'glutamate synthase
F131LOC_RS01425	COG0067	glutamate synthase
F131LOC_RS01425	COG0070	glutamate synthase
F131LOC_RS01425	COG0069	glutamate synthase activity
F131LOC_RS01430	COG1242	4 iron, 4 sulfur cluster binding
F131LOC_RS01435	COG5002	protein histidine kinase activity
F131LOC_RS01435	COG2198	Histidine kinase
F131LOC_RS01435	COG0784	Response regulator, receiver
F131LOC_RS01440	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
F131LOC_RS01445	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
F131LOC_RS01455	COG2823	Periplasmic or secreted lipoprotein
F131LOC_RS01460	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
F131LOC_RS01465	COG0792	nuclease activity
F131LOC_RS01470	COG3107	peptidoglycan biosynthetic process
F131LOC_RS01475	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
F131LOC_RS01495	COG3384	dioxygenase
F131LOC_RS01500	COG0754	glutathionylspermidine amidase activity
F131LOC_RS01505	COG5463	Belongs to the UPF0441 family
F131LOC_RS01510	COG1538	Outer membrane efflux protein
F131LOC_RS01515	COG0494	nUDIX hydrolase
F131LOC_RS01520	COG3151	Protein conserved in bacteria
F131LOC_RS01525	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
F131LOC_RS01530	COG3150	esterase
F131LOC_RS01550	COG0583	DNA-binding transcription factor activity
F131LOC_RS01555	COG2249	NAD(P)H dehydrogenase (quinone) activity
F131LOC_RS01560	COG0191	fructose-bisphosphate aldolase activity
F131LOC_RS01570	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F131LOC_RS01570	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F131LOC_RS01575	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F131LOC_RS01580	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F131LOC_RS01580	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F131LOC_RS01580	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
F131LOC_RS01585	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
F131LOC_RS01585	COG3711	transcriptional antiterminator
F131LOC_RS01590	COG4771	TonB-dependent receptor
F131LOC_RS01590	COG1629	transport
F131LOC_RS01610	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
F131LOC_RS01615	COG0204	Acyl-transferase
F131LOC_RS01620	COG2132	Multicopper oxidase
F131LOC_RS01625	COG2188	Transcriptional regulator
F131LOC_RS01630	COG0656	L-ascorbic acid biosynthetic process
F131LOC_RS01635	COG1979	alcohol dehydrogenase
F131LOC_RS01640	COG0778	Nitroreductase
F131LOC_RS01650	COG0586	Pfam SNARE associated Golgi protein
F131LOC_RS01655	COG0626	cystathionine gamma-synthase activity
F131LOC_RS01670	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
F131LOC_RS01680	COG0848	biopolymer transport protein
F131LOC_RS01720	COG1203	CRISPR-associated helicase, Cas3
F131LOC_RS01745	COG1857	crispr-associated protein
F131LOC_RS01760	COG1518	maintenance of DNA repeat elements
F131LOC_RS01765	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
F131LOC_RS01770	COG4680	protein conserved in bacteria
F131LOC_RS01785	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
F131LOC_RS01795	COG0076	glutamate decarboxylase activity
F131LOC_RS01800	COG2814	Major facilitator Superfamily
F131LOC_RS01810	COG3787	Belongs to the UPF0306 family
F131LOC_RS01815	COG0702	epimerase
F131LOC_RS01835	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
F131LOC_RS01840	COG0540	Belongs to the ATCase OTCase family
F131LOC_RS01845	COG2731	YhcH YjgK YiaL family protein
F131LOC_RS01860	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
F131LOC_RS01880	COG0501	Belongs to the peptidase M48B family
F131LOC_RS01885	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
F131LOC_RS01890	COG0840	transmembrane signaling receptor activity
F131LOC_RS01895	COG0840	transmembrane signaling receptor activity
F131LOC_RS01900	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
F131LOC_RS01905	COG0525	valine-tRNA ligase activity
F131LOC_RS01910	COG2927	DNA polymerase III (CHI subunit)
F131LOC_RS01915	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
F131LOC_RS01920	COG0795	lipopolysaccharide-transporting ATPase activity
F131LOC_RS01925	COG0795	lipopolysaccharide-transporting ATPase activity
F131LOC_RS01935	COG0582	viral genome integration into host DNA
F131LOC_RS02010	COG5433	transposase activity
F131LOC_RS02020	COG2850	peptidyl-arginine hydroxylation
F131LOC_RS02040	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F131LOC_RS02055	COG0583	DNA-binding transcription factor activity
F131LOC_RS02100	COG4650	regulator
F131LOC_RS02105	COG1690	Belongs to the RtcB family
F131LOC_RS02110	COG3541	Predicted nucleotidyltransferase
F131LOC_RS02140	COG0659	secondary active sulfate transmembrane transporter activity
F131LOC_RS02145	COG0288	reversible hydration of carbon dioxide
F131LOC_RS02150	COG0840	transmembrane signaling receptor activity
F131LOC_RS02160	COG0840	transmembrane signaling receptor activity
F131LOC_RS02165	COG3254	rhamnose metabolic process
F131LOC_RS02170	COG0235	Class ii aldolase
F131LOC_RS02175	COG4806	L-rhamnose isomerase
F131LOC_RS02180	COG1070	Carbohydrate kinase
F131LOC_RS02185	COG1917	Cupin 2, conserved barrel domain protein
F131LOC_RS02185	COG2169	Transcriptional regulator
F131LOC_RS02190	COG1917	Cupin 2, conserved barrel domain protein
F131LOC_RS02190	COG4977	sequence-specific DNA binding
F131LOC_RS02195	COG4115	mRNA cleavage
F131LOC_RS02200	COG2161	toxin-antitoxin pair type II binding
F131LOC_RS02210	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F131LOC_RS02220	COG0747	negative chemotaxis
F131LOC_RS02235	COG3477	response to acidic pH
F131LOC_RS02270	COG2862	Uncharacterized protein family, UPF0114
F131LOC_RS02275	COG2130	NADP-dependent
F131LOC_RS02305	COG3157	Type VI secretion system effector, Hcp
F131LOC_RS02310	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F131LOC_RS02315	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F131LOC_RS02320	COG0006	proline dipeptidase activity
F131LOC_RS02330	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
F131LOC_RS02340	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
F131LOC_RS02355	COG0560	Phosphoserine phosphatase
F131LOC_RS02360	COG3726	membrane protein affecting hemolysin expression
F131LOC_RS02370	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
F131LOC_RS02375	COG2823	Periplasmic or secreted lipoprotein
F131LOC_RS02380	COG5487	UPF0391 membrane protein
F131LOC_RS02390	COG0084	hydrolase, TatD family'
F131LOC_RS02395	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
F131LOC_RS02405	COG4771	TonB-dependent receptor
F131LOC_RS02415	COG1169	isochorismate synthase
F131LOC_RS02420	COG1021	2,3-dihydroxybenzoate-AMP ligase
F131LOC_RS02425	COG1535	isochorismatase
F131LOC_RS02425	COG3433	isochorismatase activity
F131LOC_RS02430	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F131LOC_RS02435	COG1028	Short-chain dehydrogenase reductase Sdr
F131LOC_RS02445	COG3321	synthase
F131LOC_RS02445	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F131LOC_RS02445	COG0300	oxidoreductase activity
F131LOC_RS02445	COG1028	Short-chain dehydrogenase reductase Sdr
F131LOC_RS02445	COG0318	PFAM AMP-dependent synthetase and ligase
F131LOC_RS02495	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
F131LOC_RS02500	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
F131LOC_RS02545	COG1309	transcriptional regulator
F131LOC_RS02550	COG4232	protein-disulfide reductase activity
F131LOC_RS02555	COG1324	tolerance protein
F131LOC_RS02560	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
F131LOC_RS02575	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
F131LOC_RS02585	COG3161	chorismate lyase activity
F131LOC_RS02590	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
F131LOC_RS02595	COG2937	Belongs to the GPAT DAPAT family
F131LOC_RS02600	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
F131LOC_RS02610	COG3237	CsbD-like
F131LOC_RS02615	COG0735	belongs to the Fur family
F131LOC_RS02620	COG1741	Belongs to the pirin family
F131LOC_RS02625	COG0583	DNA-binding transcription factor activity
F131LOC_RS02630	COG0435	Glutathione S-transferase
F131LOC_RS02635	COG2259	Doxx family
F131LOC_RS02645	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
F131LOC_RS02650	COG4575	ribosome binding
F131LOC_RS02655	COG1422	Protein of unknown function (DUF1090)
F131LOC_RS02665	COG0586	Pfam SNARE associated Golgi protein
F131LOC_RS02675	COG2271	Major facilitator Superfamily
F131LOC_RS02680	COG1904	glucuronate isomerase
F131LOC_RS02685	COG0246	Mannitol dehydrogenase
F131LOC_RS02690	COG2721	sulfolactate sulfo-lyase activity
F131LOC_RS02700	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
F131LOC_RS02705	COG0861	Integral membrane protein TerC family
F131LOC_RS02710	COG0673	inositol 2-dehydrogenase activity
F131LOC_RS02715	COG2813	Specifically methylates the guanine in position
F131LOC_RS02720	COG1902	pentaerythritol trinitrate reductase activity
F131LOC_RS02720	COG0446	pyridine nucleotide-disulphide oxidoreductase
F131LOC_RS02730	COG3678	ATP-independent chaperone mediated protein folding
F131LOC_RS02735	COG2199	diguanylate cyclase activity
F131LOC_RS02750	COG0641	radical SAM
F131LOC_RS02755	COG3408	Glycogen debranching enzyme
F131LOC_RS02755	COG3119	arylsulfatase activity
F131LOC_RS02765	COG0243	molybdopterin cofactor binding
F131LOC_RS02775	COG0583	DNA-binding transcription factor activity
F131LOC_RS02800	COG3663	DNA glycosylase
F131LOC_RS02810	COG0358	DNA primase activity
F131LOC_RS02815	COG0828	Belongs to the bacterial ribosomal protein bS21 family
F131LOC_RS02820	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
F131LOC_RS02825	COG1438	arginine binding
F131LOC_RS02830	COG0039	L-malate dehydrogenase activity
F131LOC_RS02835	COG3423	Transcriptional regulator
F131LOC_RS02850	COG0142	geranyltranstransferase activity
F131LOC_RS02855	COG0261	This protein binds to 23S rRNA in the presence of protein L20
F131LOC_RS02860	COG0211	Belongs to the bacterial ribosomal protein bL27 family
F131LOC_RS02865	COG0697	spore germination
F131LOC_RS02870	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
F131LOC_RS02875	COG2027	D-alanyl-D-alanine carboxypeptidase
F131LOC_RS02885	COG1534	Rna-binding protein
F131LOC_RS02890	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
F131LOC_RS02895	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
F131LOC_RS02900	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
F131LOC_RS02905	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
F131LOC_RS02910	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
F131LOC_RS02950	COG0779	Required for maturation of 30S ribosomal subunits
F131LOC_RS02960	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
F131LOC_RS02965	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
F131LOC_RS02970	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
F131LOC_RS02975	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
F131LOC_RS02980	COG1185	polyribonucleotide nucleotidyltransferase activity
F131LOC_RS02995	COG0513	Belongs to the DEAD box helicase family
F131LOC_RS03000	COG2194	sulfuric ester hydrolase activity
F131LOC_RS03005	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F131LOC_RS03010	COG0826	peptidase U32
F131LOC_RS03015	COG0826	peptidase U32
F131LOC_RS03020	COG3154	lipid carrier protein
F131LOC_RS03025	COG3153	acetyltransferase
F131LOC_RS03030	COG2827	Endonuclease containing a URI domain
F131LOC_RS03035	COG1473	amidohydrolase
F131LOC_RS03040	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
F131LOC_RS03045	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
F131LOC_RS03050	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
F131LOC_RS03055	COG0813	purine-nucleoside phosphorylase activity
F131LOC_RS03075	COG4178	(ABC) transporter
F131LOC_RS03085	COG3712	iron ion homeostasis
F131LOC_RS03090	COG1595	DNA-templated transcription, initiation
F131LOC_RS03100	COG0456	acetyltransferase
F131LOC_RS03105	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
F131LOC_RS03110	COG2813	Specifically methylates the guanine in position
F131LOC_RS03115	COG0656	L-ascorbic acid biosynthetic process
F131LOC_RS03165	COG1454	alcohol dehydrogenase
F131LOC_RS03170	COG0404	The glycine cleavage system catalyzes the degradation of glycine
F131LOC_RS03175	COG0509	glycine decarboxylation via glycine cleavage system
F131LOC_RS03180	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
F131LOC_RS03180	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
F131LOC_RS03185	COG1733	regulation of RNA biosynthetic process
F131LOC_RS03190	COG1028	Short-chain dehydrogenase reductase Sdr
F131LOC_RS03195	COG1175	transmembrane transport
F131LOC_RS03205	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
F131LOC_RS03210	COG3842	ATPase activity
F131LOC_RS03215	COG1653	transport
F131LOC_RS03220	COG2211	Major facilitator Superfamily
F131LOC_RS03240	COG1272	protein, Hemolysin III
F131LOC_RS03245	COG0354	folic acid binding
F131LOC_RS03250	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
F131LOC_RS03260	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
F131LOC_RS03270	COG0716	FMN binding
F131LOC_RS03280	COG0477	Major facilitator Superfamily
F131LOC_RS03285	COG4974	Belongs to the 'phage' integrase family
F131LOC_RS03290	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
F131LOC_RS03295	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
F131LOC_RS03305	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
F131LOC_RS03315	COG1733	regulation of RNA biosynthetic process
F131LOC_RS03355	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
F131LOC_RS03360	COG2867	negative regulation of translational initiation
F131LOC_RS03365	COG2914	Belongs to the UPF0125 (RnfH) family
F131LOC_RS03375	COG0497	DNA recombination
F131LOC_RS03380	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
F131LOC_RS03385	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
F131LOC_RS03390	COG1914	H( )-stimulated, divalent metal cation uptake system
F131LOC_RS03410	COG1942	4-Oxalocrotonate Tautomerase
F131LOC_RS03415	COG0477	Major facilitator Superfamily
F131LOC_RS03425	COG0494	nUDIX hydrolase
F131LOC_RS03455	COG1609	Transcriptional regulator
F131LOC_RS03460	COG1126	abc transporter atp-binding protein
F131LOC_RS03465	COG0765	amino acid transport
F131LOC_RS03475	COG3711	transcriptional antiterminator
F131LOC_RS03480	COG2723	6-phospho-beta-galactosidase activity
F131LOC_RS03485	COG1263	PTS System
F131LOC_RS03485	COG2190	(PTS) system
F131LOC_RS03485	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F131LOC_RS03490	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
F131LOC_RS03495	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
F131LOC_RS03500	COG0698	ribose 5-phosphate isomerase
F131LOC_RS03510	COG2376	Dihydroxyacetone kinase
F131LOC_RS03515	COG0149	triose-phosphate isomerase activity
F131LOC_RS03520	COG1082	Xylose isomerase domain protein TIM barrel
F131LOC_RS03525	COG2084	Dehydrogenase
F131LOC_RS03540	COG0814	amino acid
F131LOC_RS03545	COG1671	Belongs to the UPF0178 family
F131LOC_RS03550	COG0408	coproporphyrinogen oxidase activity
F131LOC_RS03555	COG0456	acetyltransferase
F131LOC_RS03565	COG4771	TonB-dependent receptor
F131LOC_RS03570	COG0612	Peptidase, M16
F131LOC_RS03575	COG4178	(ABC) transporter
F131LOC_RS03585	COG2837	iron assimilation
F131LOC_RS03590	COG4150	thiosulfate binding
F131LOC_RS03595	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
F131LOC_RS03600	COG4208	sulfate ABC transporter
F131LOC_RS03605	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
F131LOC_RS03610	COG1136	(ABC) transporter
F131LOC_RS03610	COG0577	efflux transmembrane transporter activity
F131LOC_RS03615	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F131LOC_RS03620	COG0745	RESPONSE REGULATOR receiver
F131LOC_RS03625	COG2205	protein histidine kinase activity
F131LOC_RS03630	COG2190	(PTS) system
F131LOC_RS03640	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
F131LOC_RS03650	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
F131LOC_RS03655	COG3115	cell septum assembly
F131LOC_RS03660	COG0531	amino acid
F131LOC_RS03670	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F131LOC_RS03680	COG0446	pyridine nucleotide-disulphide oxidoreductase
F131LOC_RS03685	COG0426	domain, Protein
F131LOC_RS03685	COG1773	rubredoxin
F131LOC_RS03690	COG3604	Transcriptional regulator
F131LOC_RS03695	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
F131LOC_RS03695	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
F131LOC_RS03720	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
F131LOC_RS03720	COG2169	Transcriptional regulator
F131LOC_RS03735	COG1053	succinate dehydrogenase
F131LOC_RS03735	COG3976	FMN-binding domain protein
F131LOC_RS03735	COG0431	NADPH-dependent FMN reductase
F131LOC_RS03740	COG0477	Major facilitator Superfamily
F131LOC_RS03745	COG3301	Polysulphide reductase, NrfD
F131LOC_RS03750	COG0437	4 iron, 4 sulfur cluster binding
F131LOC_RS03760	COG0583	DNA-binding transcription factor activity
F131LOC_RS03765	COG4948	Mandelate Racemase Muconate Lactonizing
F131LOC_RS03770	COG1063	alcohol dehydrogenase
F131LOC_RS03775	COG0477	Major facilitator Superfamily
F131LOC_RS03780	COG0246	Mannitol dehydrogenase
F131LOC_RS03785	COG1802	Transcriptional regulator
F131LOC_RS03800	COG0811	peptide transport
F131LOC_RS03845	COG0583	DNA-binding transcription factor activity
F131LOC_RS03850	COG0436	Aminotransferase
F131LOC_RS03860	COG4773	Receptor
F131LOC_RS03865	COG4948	Mandelate Racemase Muconate Lactonizing
F131LOC_RS03875	COG1129	ABC transporter
F131LOC_RS03890	COG3121	Chaperone
F131LOC_RS03955	COG2249	NAD(P)H dehydrogenase (quinone) activity
F131LOC_RS03970	COG1846	Transcriptional regulator
F131LOC_RS03975	COG2814	Major facilitator Superfamily
F131LOC_RS04035	COG0297	glycogen (starch) synthase activity
F131LOC_RS04060	COG3423	Transcriptional regulator
F131LOC_RS04115	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
F131LOC_RS04125	COG1902	pentaerythritol trinitrate reductase activity
F131LOC_RS04135	COG1028	Short-chain dehydrogenase reductase Sdr
F131LOC_RS04140	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
F131LOC_RS04205	COG2003	Belongs to the UPF0758 family
F131LOC_RS04280	COG1982	Orn Lys Arg decarboxylase major
F131LOC_RS04285	COG1113	amino acid transport
F131LOC_RS04300	COG5441	Belongs to the UPF0261 family
F131LOC_RS04305	COG5564	TIM-barrel signal transduction protein
F131LOC_RS04320	COG1917	Cupin 2, conserved barrel domain protein
F131LOC_RS04320	COG2169	Transcriptional regulator
F131LOC_RS04325	COG0741	lytic transglycosylase activity
F131LOC_RS04330	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
F131LOC_RS04340	COG0220	tRNA (guanine-N7-)-methyltransferase activity
F131LOC_RS04345	COG3171	Protein conserved in bacteria
F131LOC_RS04360	COG2188	Transcriptional regulator
F131LOC_RS04365	COG3624	Phosphonate C-P lyase system protein PhnG
F131LOC_RS04370	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
F131LOC_RS04375	COG3626	phosphonate metabolism
F131LOC_RS04380	COG3627	carbon phosphorus lyase activity
F131LOC_RS04385	COG4107	phosphonate C-P lyase system protein PhnK
F131LOC_RS04390	COG4778	phosphonate C-P lyase system protein PhnL
F131LOC_RS04395	COG3454	Phosphonate metabolism
F131LOC_RS04405	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
F131LOC_RS04415	COG3639	organic phosphonate transmembrane transporter activity
F131LOC_RS04420	COG0667	Aldo Keto reductase
F131LOC_RS04430	COG0861	Integral membrane protein TerC family
F131LOC_RS04435	COG3066	DNA modification
F131LOC_RS04440	COG0494	nUDIX hydrolase
F131LOC_RS04450	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
F131LOC_RS04455	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
F131LOC_RS04460	COG4969	Belongs to the N-Me-Phe pilin family
F131LOC_RS04465	COG4795	General secretion pathway protein
F131LOC_RS04480	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
F131LOC_RS04485	COG1025	Belongs to the peptidase M16 family
F131LOC_RS04490	COG1074	ATP-dependent DNA helicase activity
F131LOC_RS04495	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
F131LOC_RS04500	COG1609	Transcriptional regulator
F131LOC_RS04510	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
F131LOC_RS04510	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
F131LOC_RS04515	COG0860	N-Acetylmuramoyl-L-alanine amidase
F131LOC_RS04535	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
F131LOC_RS04540	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F131LOC_RS04550	COG1473	amidohydrolase
F131LOC_RS04555	COG4172	Belongs to the ABC transporter superfamily
F131LOC_RS04560	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F131LOC_RS04570	COG0747	negative chemotaxis
F131LOC_RS04580	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
F131LOC_RS04585	COG2166	iron-sulfur cluster assembly
F131LOC_RS04590	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
F131LOC_RS04600	COG0583	DNA-binding transcription factor activity
F131LOC_RS04605	COG2363	Small membrane protein
F131LOC_RS04610	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
F131LOC_RS04615	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F131LOC_RS04620	COG1611	Belongs to the LOG family
F131LOC_RS04625	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
F131LOC_RS04625	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
F131LOC_RS04655	COG2171	N-acyltransferase activity
F131LOC_RS04660	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
F131LOC_RS04670	COG0052	Belongs to the universal ribosomal protein uS2 family
F131LOC_RS04675	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
F131LOC_RS04680	COG0528	UMP kinase activity
F131LOC_RS04685	COG0233	cytoplasmic translational termination
F131LOC_RS04690	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
F131LOC_RS04695	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
F131LOC_RS04700	COG0575	Belongs to the CDS family
F131LOC_RS04705	COG0750	zinc metalloprotease
F131LOC_RS04710	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F131LOC_RS04715	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
F131LOC_RS04720	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
F131LOC_RS04725	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
F131LOC_RS04730	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
F131LOC_RS04735	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
F131LOC_RS04740	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
F131LOC_RS04745	COG0587	DNA-directed DNA polymerase activity
F131LOC_RS04750	COG0825	malonyl-CoA metabolic process
F131LOC_RS04755	COG0346	lactoylglutathione lyase activity
F131LOC_RS04760	COG0037	tRNA processing
F131LOC_RS04765	COG4568	rho-dependent transcription termination
F131LOC_RS04780	COG3015	lipoprotein NlpE involved in copper resistance
F131LOC_RS04785	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
F131LOC_RS04815	COG1120	ATPase activity
F131LOC_RS04820	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F131LOC_RS04825	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F131LOC_RS04830	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
F131LOC_RS04835	COG4772	TonB-dependent receptor
F131LOC_RS04840	COG3712	iron ion homeostasis
F131LOC_RS04845	COG1595	DNA-templated transcription, initiation
F131LOC_RS04850	COG4943	cyclic-guanylate-specific phosphodiesterase activity
F131LOC_RS04855	COG2824	Alkylphosphonate utilization operon protein PhnA
F131LOC_RS04860	COG2951	lytic endotransglycosylase activity
F131LOC_RS04870	COG0583	DNA-binding transcription factor activity
F131LOC_RS04900	COG2186	Transcriptional regulator
F131LOC_RS04905	COG1312	Catalyzes the dehydration of D-mannonate
F131LOC_RS04910	COG5297	Belongs to the glycosyl hydrolase family 6
F131LOC_RS04925	COG1132	(ABC) transporter
F131LOC_RS04940	COG4615	Cyclic peptide transporter
F131LOC_RS04950	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
F131LOC_RS04955	COG3123	guanosine phosphorylase activity
F131LOC_RS04960	COG2211	Major facilitator Superfamily
F131LOC_RS04965	COG1397	ADP-ribosylglycohydrolase
F131LOC_RS04970	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F131LOC_RS04975	COG2188	Transcriptional regulator
F131LOC_RS04985	COG2974	May be involved in recombination
F131LOC_RS04990	COG1940	carbohydrate kinase activity
F131LOC_RS04995	COG0419	ATPase involved in DNA repair
F131LOC_RS05000	COG0420	3'-5' exonuclease activity
F131LOC_RS05020	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
F131LOC_RS05025	COG1114	Component of the transport system for branched-chain amino acids
F131LOC_RS05035	COG0668	transmembrane transport
F131LOC_RS05040	COG0450	alkyl hydroperoxide reductase
F131LOC_RS05045	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
F131LOC_RS05050	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
F131LOC_RS05055	COG0343	queuine tRNA-ribosyltransferase activity
F131LOC_RS05060	COG1862	Preprotein translocase
F131LOC_RS05065	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F131LOC_RS05070	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F131LOC_RS05075	COG4238	major outer membrane lipoprotein
F131LOC_RS05080	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
F131LOC_RS05085	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
F131LOC_RS05085	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
F131LOC_RS05090	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
F131LOC_RS05095	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
F131LOC_RS05100	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
F131LOC_RS05105	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
F131LOC_RS05110	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
F131LOC_RS05115	COG0142	geranyltranstransferase activity
F131LOC_RS05120	COG1722	exodeoxyribonuclease VII activity
F131LOC_RS05125	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F131LOC_RS05125	COG0301	tRNA thio-modification
F131LOC_RS05135	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
F131LOC_RS05140	COG1666	GTP binding
F131LOC_RS05145	COG2814	Major facilitator Superfamily
F131LOC_RS05150	COG0109	protoheme IX farnesyltransferase activity
F131LOC_RS05155	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
F131LOC_RS05160	COG1845	cytochrome c oxidase, subunit III
F131LOC_RS05165	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
F131LOC_RS05170	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
F131LOC_RS05175	COG2223	nitrite transmembrane transporter activity
F131LOC_RS05180	COG3056	Lipoprotein
F131LOC_RS05185	COG0271	Belongs to the BolA IbaG family
F131LOC_RS05190	COG0544	peptidyl-prolyl cis-trans isomerase activity
F131LOC_RS05195	COG0740	serine-type endopeptidase activity
F131LOC_RS05200	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
F131LOC_RS05205	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
F131LOC_RS05210	COG0776	regulation of translation
F131LOC_RS05215	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
F131LOC_RS05220	COG1555	photosystem II stabilization
F131LOC_RS05225	COG0824	Thioesterase
F131LOC_RS05230	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
F131LOC_RS05235	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
F131LOC_RS05245	COG1522	sequence-specific DNA binding
F131LOC_RS05250	COG1132	(ABC) transporter
F131LOC_RS05255	COG1132	(ABC) transporter
F131LOC_RS05260	COG0347	Belongs to the P(II) protein family
F131LOC_RS05265	COG0004	ammonium transporteR
F131LOC_RS05270	COG1946	Acyl-CoA thioesterase
F131LOC_RS05275	COG3126	Type III secretion system lipoprotein chaperone (YscW)
F131LOC_RS05280	COG3695	enzyme binding
F131LOC_RS05300	COG0257	Belongs to the bacterial ribosomal protein bL36 family
F131LOC_RS05305	COG0254	rRNA binding
F131LOC_RS05310	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F131LOC_RS05315	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F131LOC_RS05320	COG1309	transcriptional regulator
F131LOC_RS05335	COG2832	Protein of unknown function (DUF454)
F131LOC_RS05340	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
F131LOC_RS05345	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
F131LOC_RS05350	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
F131LOC_RS05355	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
F131LOC_RS05360	COG0326	Molecular chaperone. Has ATPase activity
F131LOC_RS05380	COG0601	transmembrane transport
F131LOC_RS05385	COG0747	negative chemotaxis
F131LOC_RS05390	COG0563	adenylate kinase activity
F131LOC_RS05395	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
F131LOC_RS05400	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
F131LOC_RS05400	COG4651	solute:proton antiporter activity
F131LOC_RS05405	COG0737	Belongs to the 5'-nucleotidase family
F131LOC_RS05420	COG1966	Carbon starvation protein
F131LOC_RS05425	COG2879	small protein
F131LOC_RS05430	COG0523	cobalamin synthesis protein
F131LOC_RS05435	COG5434	Belongs to the glycosyl hydrolase 28 family
F131LOC_RS05445	COG3735	TraB family
F131LOC_RS05460	COG2217	Heavy metal translocating P-type atpase
F131LOC_RS05470	COG1585	Membrane protein implicated in regulation of membrane protease activity
F131LOC_RS05475	COG0330	HflC and HflK could
F131LOC_RS05480	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
F131LOC_RS05485	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
F131LOC_RS05490	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
F131LOC_RS05495	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
F131LOC_RS05505	COG2205	protein histidine kinase activity
F131LOC_RS05505	COG0784	Response regulator, receiver
F131LOC_RS05510	COG2197	response regulator
F131LOC_RS05515	COG0642	Histidine kinase
F131LOC_RS05515	COG2198	Histidine kinase
F131LOC_RS05520	COG2223	nitrite transmembrane transporter activity
F131LOC_RS05525	COG1169	isochorismate synthase
F131LOC_RS05530	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
F131LOC_RS05535	COG0596	Alpha beta hydrolase
F131LOC_RS05540	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
F131LOC_RS05545	COG1441	menaquinone biosynthetic process
F131LOC_RS05555	COG0753	catalase activity
F131LOC_RS05565	COG0814	amino acid
F131LOC_RS05575	COG3118	belongs to the thioredoxin family
F131LOC_RS05580	COG0300	oxidoreductase activity
F131LOC_RS05585	COG2755	lipolytic protein G-D-S-L family
F131LOC_RS05590	COG4181	ATPase activity
F131LOC_RS05595	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
F131LOC_RS05600	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
F131LOC_RS05605	COG0437	4 iron, 4 sulfur cluster binding
F131LOC_RS05610	COG5557	Pfam Polysulphide reductase, NrfD
F131LOC_RS05615	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
F131LOC_RS05620	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
F131LOC_RS05625	COG1773	rubredoxin
F131LOC_RS05630	COG0309	Hydrogenase expression formation protein (HypE)
F131LOC_RS05635	COG0409	Hydrogenase expression formation protein
F131LOC_RS05640	COG0298	carbon dioxide binding
F131LOC_RS05645	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
F131LOC_RS05650	COG0375	protein maturation
F131LOC_RS05655	COG3604	Transcriptional regulator
F131LOC_RS05660	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
F131LOC_RS05670	COG3260	NADH ubiquinone oxidoreductase 20
F131LOC_RS05675	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F131LOC_RS05680	COG3261	NADH dehydrogenase
F131LOC_RS05680	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
F131LOC_RS05685	COG0651	ATP synthesis coupled electron transport
F131LOC_RS05690	COG4237	Hydrogenase 4 membrane
F131LOC_RS05695	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
F131LOC_RS05700	COG0650	Formate hydrogenlyase subunit 4
F131LOC_RS05705	COG0651	ATP synthesis coupled electron transport
F131LOC_RS05710	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
F131LOC_RS05715	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
F131LOC_RS05720	COG3383	formate dehydrogenase (NAD+) activity
F131LOC_RS05725	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
F131LOC_RS05735	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
F131LOC_RS05740	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
F131LOC_RS05745	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
F131LOC_RS05750	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
F131LOC_RS05755	COG2233	PERMEase
F131LOC_RS05760	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
F131LOC_RS05765	COG1393	Belongs to the ArsC family
F131LOC_RS05770	COG4783	chaperone-mediated protein folding
F131LOC_RS05775	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
F131LOC_RS05780	COG2716	regulation of RNA biosynthetic process
F131LOC_RS05790	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
F131LOC_RS05795	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
F131LOC_RS05810	COG2707	UPF0756 membrane protein
F131LOC_RS05815	COG1444	tRNA N-acetyltransferase activity
F131LOC_RS05825	COG3118	belongs to the thioredoxin family
F131LOC_RS05840	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
F131LOC_RS05845	COG3712	iron ion homeostasis
F131LOC_RS05850	COG1595	DNA-templated transcription, initiation
F131LOC_RS05855	COG4774	siderophore transport
F131LOC_RS05860	COG4178	(ABC) transporter
F131LOC_RS05875	COG3813	Protein conserved in bacteria
F131LOC_RS05880	COG0400	carboxylic ester hydrolase activity
F131LOC_RS05895	COG1876	peptidase activity
F131LOC_RS05900	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F131LOC_RS05905	COG1393	Belongs to the ArsC family
F131LOC_RS05915	COG1794	racemase activity, acting on amino acids and derivatives
F131LOC_RS05925	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
F131LOC_RS05930	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
F131LOC_RS05935	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
F131LOC_RS05940	COG0321	lipoyl(octanoyl) transferase activity
F131LOC_RS05945	COG2921	Belongs to the UPF0250 family
F131LOC_RS05950	COG1686	Belongs to the peptidase S11 family
F131LOC_RS05955	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
F131LOC_RS05960	COG0772	Belongs to the SEDS family
F131LOC_RS05965	COG0768	penicillin binding
F131LOC_RS05970	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
F131LOC_RS05975	COG0799	negative regulation of ribosome biogenesis
F131LOC_RS05980	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
F131LOC_RS05985	COG1466	dna polymerase III delta subunit
F131LOC_RS05990	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
F131LOC_RS05995	COG0495	leucyl-tRNA aminoacylation
F131LOC_RS06000	COG2888	peptidyl-tyrosine sulfation
F131LOC_RS06005	COG1126	abc transporter atp-binding protein
F131LOC_RS06010	COG0765	amino acid transport
F131LOC_RS06015	COG0765	amino acid transport
F131LOC_RS06025	COG0815	Transfers the fatty acyl group on membrane lipoproteins
F131LOC_RS06030	COG4535	Mg2 and Co2 transporter CorC
F131LOC_RS06035	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
F131LOC_RS06040	COG1702	phosphate starvation-inducible protein PhoH
F131LOC_RS06045	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
F131LOC_RS06050	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F131LOC_RS06090	COG0367	asparagine synthase
F131LOC_RS06095	COG1846	Transcriptional regulator
F131LOC_RS06095	COG1940	carbohydrate kinase activity
F131LOC_RS06100	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
F131LOC_RS06105	COG0363	glucosamine-6-phosphate deaminase activity
F131LOC_RS06110	COG1263	PTS System
F131LOC_RS06110	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F131LOC_RS06110	COG2190	(PTS) system
F131LOC_RS06115	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
F131LOC_RS06120	COG0735	belongs to the Fur family
F131LOC_RS06125	COG0716	FMN binding
F131LOC_RS06130	COG0840	transmembrane signaling receptor activity
F131LOC_RS06140	COG0596	Alpha beta hydrolase
F131LOC_RS06145	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
F131LOC_RS06150	COG0033	Phosphoglucomutase
F131LOC_RS06160	COG0745	RESPONSE REGULATOR receiver
F131LOC_RS06165	COG2205	protein histidine kinase activity
F131LOC_RS06170	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
F131LOC_RS06175	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
F131LOC_RS06180	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
F131LOC_RS06200	COG1840	ABC-type Fe3 transport system, periplasmic component
F131LOC_RS06205	COG3842	ATPase activity
F131LOC_RS06210	COG3272	Protein of unknown function (DUF1722)
F131LOC_RS06215	COG0415	Belongs to the DNA photolyase family
F131LOC_RS06220	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
F131LOC_RS06225	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
F131LOC_RS06230	COG1984	allophanate hydrolase subunit 2
F131LOC_RS06235	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
F131LOC_RS06240	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
F131LOC_RS06245	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
F131LOC_RS06270	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
F131LOC_RS06275	COG1053	succinate dehydrogenase
F131LOC_RS06280	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
F131LOC_RS06285	COG0567	Dehydrogenase, E1 component
F131LOC_RS06290	COG0508	dehydrogenase complex catalyzes the overall conversion of
F131LOC_RS06295	COG0045	succinate-CoA ligase (ADP-forming) activity
F131LOC_RS06300	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
F131LOC_RS06310	COG1271	oxidase subunit
F131LOC_RS06315	COG1294	oxidase, subunit
F131LOC_RS06320	COG4890	Cyd operon protein YbgT
F131LOC_RS06325	COG3790	cyd operon protein YbgE
F131LOC_RS06330	COG0824	Thioesterase
F131LOC_RS06335	COG0811	peptide transport
F131LOC_RS06340	COG0848	biopolymer transport protein
F131LOC_RS06345	COG3064	Membrane
F131LOC_RS06350	COG0823	Involved in the tonB-independent uptake of proteins
F131LOC_RS06355	COG2885	chlorophyll binding
F131LOC_RS06360	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
F131LOC_RS06385	COG1811	Na channel or pump
F131LOC_RS06395	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
F131LOC_RS06405	COG1230	cation diffusion facilitator family transporter
F131LOC_RS06410	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
F131LOC_RS06415	COG0588	phosphoglycerate mutase activity
F131LOC_RS06420	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F131LOC_RS06425	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F131LOC_RS06445	COG2017	converts alpha-aldose to the beta-anomer
F131LOC_RS06450	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
F131LOC_RS06455	COG1119	ATPase activity
F131LOC_RS06460	COG2005	Transcriptional regulator
F131LOC_RS06460	COG3585	molybdate ion transport
F131LOC_RS06470	COG0725	ABC transporter, periplasmic molybdate-binding protein
F131LOC_RS06475	COG4149	molybdate abc transporter
F131LOC_RS06480	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
F131LOC_RS06495	COG0673	inositol 2-dehydrogenase activity
F131LOC_RS06505	COG2211	Major facilitator Superfamily
F131LOC_RS06510	COG0837	glucose binding
F131LOC_RS06515	COG0561	phosphatase activity
F131LOC_RS06530	COG2706	6-phosphogluconolactonase activity
F131LOC_RS06545	COG2864	formate dehydrogenase
F131LOC_RS06550	COG0437	4 iron, 4 sulfur cluster binding
F131LOC_RS06555	COG0243	molybdopterin cofactor binding
F131LOC_RS06555	COG3383	formate dehydrogenase (NAD+) activity
F131LOC_RS06560	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F131LOC_RS06560	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F131LOC_RS06565	COG0489	protein tyrosine kinase activity
F131LOC_RS06570	COG0572	uridine kinase
F131LOC_RS06575	COG0717	Belongs to the dCTP deaminase family
F131LOC_RS06580	COG2982	Protein involved in outer membrane biogenesis
F131LOC_RS06585	COG3069	C4-dicarboxylate transmembrane transporter activity
F131LOC_RS06595	COG3550	peptidyl-serine autophosphorylation
F131LOC_RS06605	COG1253	flavin adenine dinucleotide binding
F131LOC_RS06610	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
F131LOC_RS06625	COG3206	protein involved in exopolysaccharide biosynthesis
F131LOC_RS06625	COG0489	protein tyrosine kinase activity
F131LOC_RS06635	COG2244	polysaccharide biosynthetic process
F131LOC_RS06665	COG0438	transferase activity, transferring glycosyl groups
F131LOC_RS06700	COG3077	Addiction module antitoxin, RelB DinJ family
F131LOC_RS06705	COG3041	Addiction module toxin RelE StbE family
F131LOC_RS06745	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F131LOC_RS06750	COG1605	Chorismate mutase
F131LOC_RS06760	COG2723	6-phospho-beta-galactosidase activity
F131LOC_RS06765	COG3711	transcriptional antiterminator
F131LOC_RS06770	COG3706	GGDEF domain
F131LOC_RS06795	COG3962	Belongs to the TPP enzyme family
F131LOC_RS06805	COG0673	inositol 2-dehydrogenase activity
F131LOC_RS06820	COG1172	Belongs to the binding-protein-dependent transport system permease family
F131LOC_RS06830	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F131LOC_RS06840	COG3718	enzyme involved in inositol metabolism
F131LOC_RS06855	COG3842	ATPase activity
F131LOC_RS06860	COG0395	ABC-type sugar transport system, permease component
F131LOC_RS06865	COG1840	ABC-type Fe3 transport system, periplasmic component
F131LOC_RS06875	COG2723	6-phospho-beta-galactosidase activity
F131LOC_RS06880	COG2190	(PTS) system
F131LOC_RS06880	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F131LOC_RS06880	COG1263	PTS System
F131LOC_RS06885	COG2203	Gaf domain
F131LOC_RS06885	COG2199	diguanylate cyclase activity
F131LOC_RS06895	COG3615	Tellurite resistance protein tehB
F131LOC_RS06915	COG1902	pentaerythritol trinitrate reductase activity
F131LOC_RS06925	COG1028	Short-chain dehydrogenase reductase Sdr
F131LOC_RS07000	COG4227	nucleotidyltransferase activity
F131LOC_RS07025	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
F131LOC_RS07035	COG3504	Conjugal transfer protein
F131LOC_RS07040	COG3736	Type IV secretory pathway, component VirB8
F131LOC_RS07085	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
F131LOC_RS07110	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
F131LOC_RS07115	COG1733	regulation of RNA biosynthetic process
F131LOC_RS07120	COG0154	amidase activity
F131LOC_RS07150	COG0582	viral genome integration into host DNA
F131LOC_RS07160	COG2223	nitrite transmembrane transporter activity
F131LOC_RS07165	COG3250	beta-galactosidase activity
F131LOC_RS07170	COG1609	Transcriptional regulator
F131LOC_RS07175	COG3842	ATPase activity
F131LOC_RS07185	COG1840	ABC-type Fe3 transport system, periplasmic component
F131LOC_RS07190	COG2271	Major facilitator Superfamily
F131LOC_RS07205	COG1464	Belongs to the NlpA lipoprotein family
F131LOC_RS07220	COG0583	DNA-binding transcription factor activity
F131LOC_RS07225	COG1301	dicarboxylic acid transport
F131LOC_RS07235	COG2851	Citrate transporter
F131LOC_RS07240	COG3383	formate dehydrogenase (NAD+) activity
F131LOC_RS07250	COG0672	)-iron permease
F131LOC_RS07265	COG0577	efflux transmembrane transporter activity
F131LOC_RS07265	COG1136	(ABC) transporter
F131LOC_RS07275	COG0577	efflux transmembrane transporter activity
F131LOC_RS07275	COG1136	(ABC) transporter
F131LOC_RS07285	COG0697	spore germination
F131LOC_RS07300	COG1301	dicarboxylic acid transport
F131LOC_RS07305	COG0371	Dehydrogenase
F131LOC_RS07310	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F131LOC_RS07335	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F131LOC_RS07340	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
F131LOC_RS07345	COG2515	1-aminocyclopropane-1-carboxylate deaminase
F131LOC_RS07355	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
F131LOC_RS07400	COG1012	belongs to the aldehyde dehydrogenase family
F131LOC_RS07405	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
F131LOC_RS07410	COG0840	transmembrane signaling receptor activity
F131LOC_RS07425	COG0477	Major facilitator Superfamily
F131LOC_RS07440	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
F131LOC_RS07445	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F131LOC_RS07450	COG0747	negative chemotaxis
F131LOC_RS07485	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F131LOC_RS07505	COG4771	TonB-dependent receptor
F131LOC_RS07520	COG1132	(ABC) transporter
F131LOC_RS07520	COG2375	cellular response to nickel ion
F131LOC_RS07525	COG1132	(ABC) transporter
F131LOC_RS07545	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
F131LOC_RS07545	COG3008	intermembrane lipid transfer
F131LOC_RS07550	COG2995	paraquat-inducible protein a
F131LOC_RS07565	COG0835	chemotaxis
F131LOC_RS07565	COG0784	Response regulator, receiver
F131LOC_RS07575	COG3226	Transcriptional regulator
F131LOC_RS07580	COG2814	Major facilitator Superfamily
F131LOC_RS07585	COG0625	glutathione transferase activity
F131LOC_RS07590	COG2910	NAD(P)H-binding
F131LOC_RS07595	COG1733	regulation of RNA biosynthetic process
F131LOC_RS07610	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
F131LOC_RS07615	COG0640	Transcriptional regulator
F131LOC_RS07620	COG1733	regulation of RNA biosynthetic process
F131LOC_RS07640	COG2814	Major facilitator Superfamily
F131LOC_RS07645	COG2814	Major facilitator Superfamily
F131LOC_RS07650	COG4978	Transcriptional regulator
F131LOC_RS07650	COG0789	Transcriptional regulator
F131LOC_RS07655	COG2723	6-phospho-beta-galactosidase activity
F131LOC_RS07665	COG3122	Protein conserved in bacteria
F131LOC_RS07675	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
F131LOC_RS07675	COG2169	Transcriptional regulator
F131LOC_RS07725	COG2207	Transcriptional regulator
F131LOC_RS07730	COG2249	NAD(P)H dehydrogenase (quinone) activity
F131LOC_RS07735	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
F131LOC_RS07740	COG0667	Aldo Keto reductase
F131LOC_RS07760	COG1073	alpha beta
F131LOC_RS07770	COG5002	protein histidine kinase activity
F131LOC_RS07795	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
F131LOC_RS07810	COG3228	Belongs to the MtfA family
F131LOC_RS07835	COG0401	homolog of Blt101
F131LOC_RS07840	COG0471	metal ion transport
F131LOC_RS07850	COG2188	Transcriptional regulator
F131LOC_RS07870	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
F131LOC_RS07875	COG0303	'Molybdopterin
F131LOC_RS07880	COG4172	Belongs to the ABC transporter superfamily
F131LOC_RS07885	COG0747	negative chemotaxis
F131LOC_RS07890	COG0601	transmembrane transport
F131LOC_RS07895	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F131LOC_RS07900	COG0281	malic enzyme
F131LOC_RS07905	COG0295	cytidine deaminase activity
F131LOC_RS07910	COG1346	cytolysis
F131LOC_RS07915	COG1380	Effector of murein hydrolase LrgA
F131LOC_RS07920	COG5297	Belongs to the glycosyl hydrolase family 6
F131LOC_RS07930	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
F131LOC_RS07935	COG0156	8-amino-7-oxononanoate synthase activity
F131LOC_RS07940	COG2226	methyltransferase
F131LOC_RS07945	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
F131LOC_RS07950	COG3157	Type VI secretion system effector, Hcp
F131LOC_RS07970	COG0556	nucleotide-excision repair
F131LOC_RS07985	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
F131LOC_RS07990	COG0521	Mo-molybdopterin cofactor biosynthetic process
F131LOC_RS07995	COG0315	cyclic pyranopterin monophosphate synthase activity
F131LOC_RS08000	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
F131LOC_RS08005	COG0314	molybdopterin synthase activity
F131LOC_RS08010	COG0670	Belongs to the BI1 family
F131LOC_RS08015	COG0842	Transport permease protein
F131LOC_RS08020	COG0842	Transport permease protein
F131LOC_RS08025	COG1131	(ABC) transporter
F131LOC_RS08040	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
F131LOC_RS08045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F131LOC_RS08050	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F131LOC_RS08055	COG1120	ATPase activity
F131LOC_RS08065	COG0513	Belongs to the DEAD box helicase family
F131LOC_RS08075	COG3708	Transcriptional regulator
F131LOC_RS08075	COG2207	Transcriptional regulator
F131LOC_RS08080	COG2195	Cleaves the N-terminal amino acid of tripeptides
F131LOC_RS08085	COG0747	negative chemotaxis
F131LOC_RS08090	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
F131LOC_RS08095	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
F131LOC_RS08100	COG0833	amino acid
F131LOC_RS08105	COG2040	homocysteine
F131LOC_RS08130	COG1686	Belongs to the peptidase S11 family
F131LOC_RS08145	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
F131LOC_RS08235	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
F131LOC_RS08295	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
F131LOC_RS08300	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
F131LOC_RS08310	COG1126	abc transporter atp-binding protein
F131LOC_RS08315	COG0765	amino acid transport
F131LOC_RS08320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F131LOC_RS08325	COG0783	Belongs to the Dps family
F131LOC_RS08330	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
F131LOC_RS08330	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
F131LOC_RS08340	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
F131LOC_RS08350	COG2807	transmembrane transport
F131LOC_RS08355	COG0534	Mate efflux family protein
F131LOC_RS08360	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F131LOC_RS08375	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
F131LOC_RS08400	COG3083	sulfuric ester hydrolase activity
F131LOC_RS08405	COG3082	Protein of unknown function (DUF1414)
F131LOC_RS08410	COG3081	Nucleoid-associated protein
F131LOC_RS08420	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
F131LOC_RS08425	COG1061	Type III restriction enzyme res subunit
F131LOC_RS08440	COG2814	Major facilitator Superfamily
F131LOC_RS08450	COG4172	Belongs to the ABC transporter superfamily
F131LOC_RS08455	COG4239	(ABC) transporter, permease
F131LOC_RS08460	COG4174	ABC transporter (Permease)
F131LOC_RS08465	COG4166	transmembrane transport
F131LOC_RS08470	COG0625	glutathione transferase activity
F131LOC_RS08485	COG0791	NLP P60 protein
F131LOC_RS08490	COG0671	phosphoesterase, PA-phosphatase related
F131LOC_RS08495	COG0523	cobalamin synthesis protein
F131LOC_RS08500	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
F131LOC_RS08515	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
F131LOC_RS08515	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
F131LOC_RS08520	COG1105	Belongs to the carbohydrate kinase PfkB family
F131LOC_RS08525	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
F131LOC_RS08525	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F131LOC_RS08525	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F131LOC_RS08530	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
F131LOC_RS08535	COG2855	membrane
F131LOC_RS08540	COG0583	DNA-binding transcription factor activity
F131LOC_RS08545	COG0833	amino acid
F131LOC_RS08550	COG4771	TonB-dependent receptor
F131LOC_RS08555	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F131LOC_RS08560	COG1172	Belongs to the binding-protein-dependent transport system permease family
F131LOC_RS08565	COG1129	ABC transporter
F131LOC_RS08570	COG0371	Dehydrogenase
F131LOC_RS08595	COG0583	DNA-binding transcription factor activity
F131LOC_RS08600	COG0840	transmembrane signaling receptor activity
F131LOC_RS08605	COG0302	gtp cyclohydrolase
F131LOC_RS08610	COG2311	Membrane
F131LOC_RS08615	COG2949	membrane
F131LOC_RS08620	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
F131LOC_RS08625	COG2133	pyrroloquinoline quinone binding
F131LOC_RS08630	COG0625	glutathione transferase activity
F131LOC_RS08640	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
F131LOC_RS08645	COG2011	ABC-type metal ion transport system permease component
F131LOC_RS08650	COG1686	Belongs to the peptidase S11 family
F131LOC_RS08655	COG1349	DNA-binding transcription factor activity
F131LOC_RS08660	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
F131LOC_RS08665	COG0569	domain protein
F131LOC_RS08665	COG2985	domain, Protein
F131LOC_RS08680	COG0778	Nitroreductase
F131LOC_RS08685	COG0189	ligase activity
F131LOC_RS08695	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
F131LOC_RS08700	COG3842	ATPase activity
F131LOC_RS08705	COG1176	ABC-type spermidine putrescine transport system, permease component I
F131LOC_RS08710	COG1177	transmembrane transport
F131LOC_RS08720	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
F131LOC_RS08725	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F131LOC_RS08730	COG4160	amino acid transport
F131LOC_RS08735	COG4215	(ABC) transporter
F131LOC_RS08740	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F131LOC_RS08745	COG1126	abc transporter atp-binding protein
F131LOC_RS08750	COG0393	Putative heavy-metal-binding
F131LOC_RS08755	COG3023	N-Acetylmuramoyl-L-alanine amidase
F131LOC_RS08760	COG0702	epimerase
F131LOC_RS08765	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
F131LOC_RS08770	COG1151	hydroxylamine reductase activity
F131LOC_RS08775	COG2431	L-lysine efflux transmembrane transporter activity
F131LOC_RS08780	COG3593	DNA synthesis involved in DNA repair
F131LOC_RS08785	COG1278	Cold shock
F131LOC_RS08790	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
F131LOC_RS08795	COG0542	response to heat
F131LOC_RS08800	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
F131LOC_RS08810	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
F131LOC_RS08815	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
F131LOC_RS08820	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
F131LOC_RS08825	COG4988	ABC transporter
F131LOC_RS08830	COG0492	ferredoxin-NADP+ reductase activity
F131LOC_RS08840	COG1674	ftsk spoiiie
F131LOC_RS08840	COG3107	peptidoglycan biosynthetic process
F131LOC_RS08845	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
F131LOC_RS08850	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
F131LOC_RS08855	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
F131LOC_RS08860	COG0477	Major facilitator Superfamily
F131LOC_RS08885	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
F131LOC_RS08890	COG1882	Formate acetyltransferase
F131LOC_RS08895	COG2116	formate transmembrane transporter activity
F131LOC_RS08900	COG1944	ATP diphosphatase activity
F131LOC_RS08905	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
F131LOC_RS08910	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
F131LOC_RS08915	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
F131LOC_RS08920	COG0539	negative regulation of cytoplasmic translation
F131LOC_RS08925	COG0776	regulation of translation
F131LOC_RS08935	COG0140	phosphoribosyl-ATP diphosphatase activity
F131LOC_RS08935	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
F131LOC_RS08940	COG0107	imidazoleglycerol-phosphate synthase activity
F131LOC_RS08945	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
F131LOC_RS08950	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
F131LOC_RS08955	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
F131LOC_RS08955	COG0131	Imidazoleglycerol-phosphate dehydratase
F131LOC_RS08960	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
F131LOC_RS08965	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
F131LOC_RS08970	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
F131LOC_RS08975	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F131LOC_RS08980	COG0840	transmembrane signaling receptor activity
F131LOC_RS08985	COG0840	transmembrane signaling receptor activity
F131LOC_RS08990	COG4565	transcriptional regulatory protein
F131LOC_RS09000	COG3493	citrate carrier protein
F131LOC_RS09005	COG0179	Fumarylacetoacetate (FAA) hydrolase
F131LOC_RS09010	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
F131LOC_RS09015	COG3052	prosthetic group binding
F131LOC_RS09035	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
F131LOC_RS09040	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
F131LOC_RS09050	COG0531	amino acid
F131LOC_RS09055	COG2925	Exonuclease
F131LOC_RS09060	COG4607	ABC-type enterochelin transport system periplasmic component
F131LOC_RS09070	COG4605	iron ion homeostasis
F131LOC_RS09075	COG4604	ABC transporter, ATP-binding protein
F131LOC_RS09080	COG2926	Belongs to the UPF0265 family
F131LOC_RS09085	COG0658	competence protein
F131LOC_RS09085	COG2333	competence protein COMEC
F131LOC_RS09090	COG1132	(ABC) transporter
F131LOC_RS09095	COG1663	tetraacyldisaccharide 4'-kinase activity
F131LOC_RS09100	COG2835	tetraacyldisaccharide 4'-kinase activity
F131LOC_RS09105	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
F131LOC_RS09115	COG3173	Aminoglycoside phosphotransferase
F131LOC_RS09120	COG1434	Gram-negative-bacterium-type cell wall biogenesis
F131LOC_RS09125	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
F131LOC_RS09130	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
F131LOC_RS09135	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
F131LOC_RS09140	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
F131LOC_RS09145	COG2989	Protein conserved in bacteria
F131LOC_RS09150	COG3108	Peptidase M15
F131LOC_RS09155	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F131LOC_RS09160	COG1448	Aminotransferase
F131LOC_RS09170	COG0017	Asparaginyl-tRNA synthetase
F131LOC_RS09175	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
F131LOC_RS09180	COG0308	aminopeptidase N
F131LOC_RS09185	COG0167	dihydroorotate dehydrogenase activity
F131LOC_RS09195	COG0633	Ferredoxin
F131LOC_RS09195	COG3217	Mosc domain protein beta barrel domain protein
F131LOC_RS09200	COG0116	Belongs to the methyltransferase superfamily
F131LOC_RS09200	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
F131LOC_RS09205	COG0488	(ABC) transporter
F131LOC_RS09210	COG2995	paraquat-inducible protein a
F131LOC_RS09215	COG3008	intermembrane lipid transfer
F131LOC_RS09215	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
F131LOC_RS09220	COG3009	Protein conserved in bacteria
F131LOC_RS09225	COG3130	regulation of translation
F131LOC_RS09230	COG0840	transmembrane signaling receptor activity
F131LOC_RS09240	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
F131LOC_RS09245	COG3381	protein complex oligomerization
F131LOC_RS09255	COG2999	glutathione oxidoreductase activity
F131LOC_RS09260	COG0477	Major facilitator Superfamily
F131LOC_RS09265	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F131LOC_RS09270	COG3132	Protein of unknown function, DUF480
F131LOC_RS09280	COG0728	peptidoglycan biosynthetic process
F131LOC_RS09285	COG0018	arginyl-trna synthetase
F131LOC_RS09290	COG3102	Protein conserved in bacteria
F131LOC_RS09295	COG3142	Participates in the control of copper homeostasis
F131LOC_RS09300	COG0500	methyltransferase
F131LOC_RS09305	COG2226	methyltransferase
F131LOC_RS09310	COG3788	relative of glutathione S-transferase, MAPEG superfamily
F131LOC_RS09315	COG1801	Protein of unknown function DUF72
F131LOC_RS09320	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
F131LOC_RS09325	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
F131LOC_RS09330	COG0494	nUDIX hydrolase
F131LOC_RS09335	COG0217	transcriptional regulatory protein
F131LOC_RS09340	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
F131LOC_RS09345	COG0632	four-way junction helicase activity
F131LOC_RS09350	COG2255	four-way junction helicase activity
F131LOC_RS09355	COG4580	involved in the transport of maltose and maltodextrins
F131LOC_RS09360	COG1447	Phosphotransferase system cellobiose-specific component IIA
F131LOC_RS09370	COG1609	Transcriptional regulator
F131LOC_RS09375	COG1108	ABC-type Mn2 Zn2 transport systems permease components
F131LOC_RS09380	COG1121	(ABC) transporter
F131LOC_RS09385	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
F131LOC_RS09390	COG0739	heme binding
F131LOC_RS09395	COG1560	Kdo2-lipid A biosynthetic process
F131LOC_RS09400	COG0469	pyruvate kinase activity
F131LOC_RS09405	COG1737	Transcriptional regulator
F131LOC_RS09410	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
F131LOC_RS09415	COG0800	Aldolase
F131LOC_RS09420	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
F131LOC_RS09425	COG1770	oligopeptidase
F131LOC_RS09435	COG1528	Iron-storage protein
F131LOC_RS09445	COG1278	Cold shock
F131LOC_RS09465	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
F131LOC_RS09480	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
F131LOC_RS09480	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
F131LOC_RS09485	COG3008	intermembrane lipid transfer
F131LOC_RS09490	COG2995	paraquat-inducible protein a
F131LOC_RS09495	COG1956	GAF domain-containing protein
F131LOC_RS09500	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
F131LOC_RS09510	COG2207	Transcriptional regulator
F131LOC_RS09525	COG1177	transmembrane transport
F131LOC_RS09535	COG3842	ATPase activity
F131LOC_RS09540	COG2195	Cleaves the N-terminal amino acid of tripeptides
F131LOC_RS09545	COG2850	peptidyl-arginine hydroxylation
F131LOC_RS09560	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
F131LOC_RS09565	COG2915	High frequency lysogenization protein hflD homolog
F131LOC_RS09570	COG0482	sulfurtransferase activity
F131LOC_RS09580	COG1187	pseudouridine synthase activity
F131LOC_RS09585	COG0538	isocitrate dehydrogenase activity
F131LOC_RS09590	COG0348	domain, Protein
F131LOC_RS09610	COG3300	MHYT domain
F131LOC_RS09610	COG5001	Diguanylate cyclase
F131LOC_RS09615	COG3275	phosphorelay sensor kinase activity
F131LOC_RS09620	COG3279	Response regulator of the LytR AlgR family
F131LOC_RS09625	COG2223	nitrite transmembrane transporter activity
F131LOC_RS09630	COG1653	transport
F131LOC_RS09640	COG0501	Belongs to the peptidase M48B family
F131LOC_RS09645	COG0823	Involved in the tonB-independent uptake of proteins
F131LOC_RS09660	COG1113	amino acid transport
F131LOC_RS09665	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
F131LOC_RS09670	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
F131LOC_RS09675	COG0291	Belongs to the bacterial ribosomal protein bL35 family
F131LOC_RS09680	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
F131LOC_RS09690	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
F131LOC_RS09695	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F131LOC_RS09695	COG0072	phenylalanine-tRNA ligase activity
F131LOC_RS09700	COG0776	regulation of translation
F131LOC_RS09710	COG1132	(ABC) transporter
F131LOC_RS09720	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
F131LOC_RS09725	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F131LOC_RS09730	COG1823	symporter activity
F131LOC_RS09735	COG1988	membrane-bound metal-dependent
F131LOC_RS09740	COG2755	lipolytic protein G-D-S-L family
F131LOC_RS09740	COG0657	acetylesterase activity
F131LOC_RS09745	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
F131LOC_RS09755	COG3842	ATPase activity
F131LOC_RS09760	COG0395	ABC-type sugar transport system, permease component
F131LOC_RS09765	COG1175	transmembrane transport
F131LOC_RS09775	COG1028	Short-chain dehydrogenase reductase Sdr
F131LOC_RS09785	COG1917	Cupin 2, conserved barrel domain protein
F131LOC_RS09790	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F131LOC_RS09800	COG3001	Fructosamine kinase
F131LOC_RS09805	COG1108	ABC-type Mn2 Zn2 transport systems permease components
F131LOC_RS09810	COG1108	ABC-type Mn2 Zn2 transport systems permease components
F131LOC_RS09815	COG1121	(ABC) transporter
F131LOC_RS09820	COG0803	Belongs to the bacterial solute-binding protein 9 family
F131LOC_RS09835	COG2226	methyltransferase
F131LOC_RS09840	COG1971	Probably functions as a manganese efflux pump
F131LOC_RS09845	COG4811	Protein of unknown function (DUF986)
F131LOC_RS09850	COG3716	PTS system mannose fructose sorbose family IID component
F131LOC_RS09855	COG3715	PTS system
F131LOC_RS09865	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
F131LOC_RS09865	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F131LOC_RS09870	COG1253	flavin adenine dinucleotide binding
F131LOC_RS09900	COG1760	l-serine dehydratase
F131LOC_RS09905	COG0494	nUDIX hydrolase
F131LOC_RS09910	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
F131LOC_RS09915	COG3140	Belongs to the UPF0181 family
F131LOC_RS09920	COG0251	oxidation-reduction process
F131LOC_RS09925	COG1199	ATP-dependent helicase activity
F131LOC_RS09935	COG3065	identical protein binding
F131LOC_RS09940	COG0318	PFAM AMP-dependent synthetase and ligase
F131LOC_RS09945	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
F131LOC_RS09950	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
F131LOC_RS09955	COG2894	cell division
F131LOC_RS09960	COG0850	regulation of cytokinetic process
F131LOC_RS09965	COG3100	YcgL domain-containing protein
F131LOC_RS09970	COG0179	Fumarylacetoacetate (FAA) hydrolase
F131LOC_RS09975	COG2983	Belongs to the UPF0260 family
F131LOC_RS09990	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
F131LOC_RS09995	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
F131LOC_RS10000	COG2186	Transcriptional regulator
F131LOC_RS10005	COG2719	SpoVR family
F131LOC_RS10010	COG3684	Belongs to the aldolase LacD family
F131LOC_RS10040	COG0205	6-phosphofructokinase activity
F131LOC_RS10045	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F131LOC_RS10060	COG2718	Belongs to the UPF0229 family
F131LOC_RS10065	COG2766	serine protein kinase
F131LOC_RS10070	COG3713	MltA-interacting MipA family protein
F131LOC_RS10075	COG0656	L-ascorbic acid biosynthetic process
F131LOC_RS10090	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F131LOC_RS10095	COG3139	Protein of unknown function (DUF1315)
F131LOC_RS10100	COG1335	isochorismatase
F131LOC_RS10105	COG0252	asparaginase activity
F131LOC_RS10110	COG0616	signal peptide processing
F131LOC_RS10115	COG0778	Nitroreductase
F131LOC_RS10120	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
F131LOC_RS10130	COG0708	Exodeoxyribonuclease III
F131LOC_RS10135	COG2860	membrane
F131LOC_RS10155	COG0788	formyltetrahydrofolate deformylase activity
F131LOC_RS10160	COG3012	SEC-C Motif Domain Protein
F131LOC_RS10165	COG1752	Esterase of the alpha-beta hydrolase superfamily
F131LOC_RS10170	COG0745	RESPONSE REGULATOR receiver
F131LOC_RS10175	COG1210	Utp--glucose-1-phosphate uridylyltransferase
F131LOC_RS10185	COG1435	thymidine kinase activity
F131LOC_RS10190	COG1454	alcohol dehydrogenase
F131LOC_RS10190	COG1012	belongs to the aldehyde dehydrogenase family
F131LOC_RS10205	COG0601	transmembrane transport
F131LOC_RS10210	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F131LOC_RS10215	COG0444	Belongs to the ABC transporter superfamily
F131LOC_RS10225	COG3099	Belongs to the UPF0263 family
F131LOC_RS10230	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
F131LOC_RS10245	COG2350	Protein conserved in bacteria
F131LOC_RS10255	COG1607	acyl-coa hydrolase
F131LOC_RS10260	COG2917	probably involved in intracellular septation
F131LOC_RS10270	COG3047	cAMP biosynthetic process
F131LOC_RS10275	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
F131LOC_RS10280	COG0159	tryptophan synthase activity
F131LOC_RS10285	COG0133	tryptophan synthase activity
F131LOC_RS10290	COG0135	phosphoribosylanthranilate isomerase activity
F131LOC_RS10290	COG0134	indole-3-glycerol-phosphate synthase activity
F131LOC_RS10295	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
F131LOC_RS10300	COG0512	Glutamine amidotransferase of anthranilate synthase
F131LOC_RS10310	COG0613	PHP domain protein
F131LOC_RS10315	COG0009	L-threonylcarbamoyladenylate synthase
F131LOC_RS10320	COG1187	pseudouridine synthase activity
F131LOC_RS10325	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
F131LOC_RS10330	COG1028	Short-chain dehydrogenase reductase Sdr
F131LOC_RS10335	COG0616	signal peptide processing
F131LOC_RS10355	COG3104	oligopeptide transport
F131LOC_RS10360	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
F131LOC_RS10370	COG4659	FMN binding
F131LOC_RS10375	COG4658	electron transport chain
F131LOC_RS10380	COG4656	Part of a membrane complex involved in electron transport
F131LOC_RS10385	COG2878	Part of a membrane complex involved in electron transport
F131LOC_RS10390	COG4657	Part of a membrane complex involved in electron transport
F131LOC_RS10400	COG2160	L-arabinose isomerase activity
F131LOC_RS10405	COG1069	ribulokinase activity
F131LOC_RS10410	COG1879	ABC-type sugar transport system periplasmic component
F131LOC_RS10415	COG1129	ABC transporter
F131LOC_RS10420	COG1172	Belongs to the binding-protein-dependent transport system permease family
F131LOC_RS10430	COG0673	inositol 2-dehydrogenase activity
F131LOC_RS10435	COG0385	Bile acid
F131LOC_RS10445	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
F131LOC_RS10455	COG5339	Protein conserved in bacteria
F131LOC_RS10460	COG1482	cell wall glycoprotein biosynthetic process
F131LOC_RS10465	COG0114	fumarate hydratase activity
F131LOC_RS10475	COG2814	Major facilitator Superfamily
F131LOC_RS10480	COG0583	DNA-binding transcription factor activity
F131LOC_RS10485	COG1940	carbohydrate kinase activity
F131LOC_RS10490	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
F131LOC_RS10495	COG0477	Major facilitator Superfamily
F131LOC_RS10515	COG4221	oxidoreductase activity
F131LOC_RS10520	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
F131LOC_RS10525	COG1215	transferase activity, transferring glycosyl groups
F131LOC_RS10540	COG1942	4-Oxalocrotonate Tautomerase
F131LOC_RS10545	COG0076	glutamate decarboxylase activity
F131LOC_RS10550	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
F131LOC_RS10565	COG1649	PFAM Uncharacterised BCR, COG1649
F131LOC_RS10570	COG4628	conserved protein (DUF2132)
F131LOC_RS10600	COG0745	RESPONSE REGULATOR receiver
F131LOC_RS10605	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
F131LOC_RS10670	COG0456	acetyltransferase
F131LOC_RS10675	COG0738	Major facilitator superfamily
F131LOC_RS10685	COG3783	Cytochrome b(562)
F131LOC_RS10690	COG1764	response to oxidative stress
F131LOC_RS10695	COG4305	rare lipoprotein A
F131LOC_RS10720	COG1028	Short-chain dehydrogenase reductase Sdr
F131LOC_RS10735	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
F131LOC_RS10750	COG0673	inositol 2-dehydrogenase activity
F131LOC_RS10755	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
F131LOC_RS10760	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F131LOC_RS10770	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
F131LOC_RS10775	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
F131LOC_RS10785	COG2877	3-deoxy-8-phosphooctulonate synthase activity
F131LOC_RS10790	COG2912	Transglutaminase-like superfamily
F131LOC_RS10800	COG2890	protein-(glutamine-N5) methyltransferase activity
F131LOC_RS10805	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
F131LOC_RS10810	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
F131LOC_RS10815	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
F131LOC_RS10820	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
F131LOC_RS10825	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
F131LOC_RS10835	COG0193	aminoacyl-tRNA hydrolase activity
F131LOC_RS10840	COG0012	GTP binding
F131LOC_RS10885	COG0523	cobalamin synthesis protein
F131LOC_RS10915	COG0346	lactoylglutathione lyase activity
F131LOC_RS10920	COG0483	inositol monophosphate 1-phosphatase activity
F131LOC_RS10925	COG2723	6-phospho-beta-galactosidase activity
F131LOC_RS10930	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F131LOC_RS10930	COG1263	PTS System
F131LOC_RS10935	COG1609	Transcriptional regulator
F131LOC_RS10965	COG2826	transposase and inactivated derivatives, IS30 family
F131LOC_RS10990	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F131LOC_RS10995	COG1473	amidohydrolase
F131LOC_RS11005	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F131LOC_RS11015	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
F131LOC_RS11025	COG0765	amino acid transport
F131LOC_RS11030	COG1126	abc transporter atp-binding protein
F131LOC_RS11040	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
F131LOC_RS11045	COG0640	Transcriptional regulator
F131LOC_RS11060	COG1129	ABC transporter
F131LOC_RS11080	COG1802	Transcriptional regulator
F131LOC_RS11155	COG2831	hemolysin activation secretion protein
F131LOC_RS11160	COG1802	Transcriptional regulator
F131LOC_RS11210	COG3501	Rhs element vgr protein
F131LOC_RS11255	COG4669	(LipO)protein
F131LOC_RS11270	COG2200	EAL domain
F131LOC_RS11280	COG2197	response regulator
F131LOC_RS11335	COG4794	Type iii secretion
F131LOC_RS11345	COG4792	protein secretion
F131LOC_RS11360	COG0583	DNA-binding transcription factor activity
F131LOC_RS11375	COG1464	Belongs to the NlpA lipoprotein family
F131LOC_RS11380	COG4948	Mandelate Racemase Muconate Lactonizing
F131LOC_RS11385	COG2011	ABC-type metal ion transport system permease component
F131LOC_RS11390	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
F131LOC_RS11395	COG0671	phosphoesterase, PA-phosphatase related
F131LOC_RS11405	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
F131LOC_RS11415	COG1028	Short-chain dehydrogenase reductase Sdr
F131LOC_RS11425	COG1176	ABC-type spermidine putrescine transport system, permease component I
F131LOC_RS11440	COG1012	belongs to the aldehyde dehydrogenase family
F131LOC_RS11445	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
F131LOC_RS11455	COG3842	ATPase activity
F131LOC_RS11460	COG1028	Short-chain dehydrogenase reductase Sdr
F131LOC_RS11475	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
F131LOC_RS11485	COG2255	four-way junction helicase activity
F131LOC_RS11490	COG2261	transglycosylase associated protein
F131LOC_RS11510	COG2423	ornithine cyclodeaminase activity
F131LOC_RS11525	COG1846	Transcriptional regulator
F131LOC_RS11530	COG0697	spore germination
F131LOC_RS11535	COG2181	nitrate reductase activity
F131LOC_RS11540	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
F131LOC_RS11545	COG1140	nitrate reductase beta subunit
F131LOC_RS11550	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
F131LOC_RS11555	COG2223	nitrite transmembrane transporter activity
F131LOC_RS11560	COG3850	Histidine kinase
F131LOC_RS11565	COG2197	response regulator
F131LOC_RS11580	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
F131LOC_RS11590	COG0387	Pfam Sodium calcium exchanger
F131LOC_RS11595	COG0659	secondary active sulfate transmembrane transporter activity
F131LOC_RS11605	COG1028	Short-chain dehydrogenase reductase Sdr
F131LOC_RS11630	COG0745	RESPONSE REGULATOR receiver
F131LOC_RS11635	COG2205	protein histidine kinase activity
F131LOC_RS11645	COG3591	Belongs to the peptidase S1B family
F131LOC_RS11650	COG5001	Diguanylate cyclase
F131LOC_RS11650	COG3300	MHYT domain
F131LOC_RS11660	COG1643	Atp-dependent helicase
F131LOC_RS11665	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
F131LOC_RS11675	COG2911	Protein conserved in bacteria
F131LOC_RS11680	COG0840	transmembrane signaling receptor activity
F131LOC_RS11685	COG0840	transmembrane signaling receptor activity
F131LOC_RS11690	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F131LOC_RS11720	COG0037	tRNA processing
F131LOC_RS11730	COG0598	Magnesium transport protein CorA
F131LOC_RS11735	COG4166	transmembrane transport
F131LOC_RS11740	COG2866	Carboxypeptidase
F131LOC_RS11745	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
F131LOC_RS11770	COG3768	UPF0283 membrane protein
F131LOC_RS11775	COG3106	COG3106 Predicted ATPase
F131LOC_RS11780	COG2831	hemolysin activation secretion protein
F131LOC_RS11790	COG3210	domain, Protein
F131LOC_RS11805	COG1983	PspC domain protein
F131LOC_RS11815	COG1842	Phage shock protein A
F131LOC_RS11820	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
F131LOC_RS11840	COG4166	transmembrane transport
F131LOC_RS11850	COG4171	peptide transport system, permease
F131LOC_RS11890	COG2271	Major facilitator Superfamily
F131LOC_RS11900	COG0583	DNA-binding transcription factor activity
F131LOC_RS11905	COG0243	molybdopterin cofactor binding
F131LOC_RS11910	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
F131LOC_RS11915	COG4989	oxidoreductase activity
F131LOC_RS11925	COG2814	Major facilitator Superfamily
F131LOC_RS11930	COG1966	Carbon starvation protein
F131LOC_RS11935	COG3385	transposase activity
F131LOC_RS11940	COG0235	Class ii aldolase
F131LOC_RS11950	COG0023	Translation Initiation Factor
F131LOC_RS11955	COG0284	orotidine-5'-phosphate decarboxylase activity
F131LOC_RS11960	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
F131LOC_RS11965	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
F131LOC_RS11975	COG1082	Xylose isomerase domain protein TIM barrel
F131LOC_RS11980	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
F131LOC_RS11985	COG3958	Transketolase
F131LOC_RS11990	COG3959	Transketolase, thiamine diphosphate binding domain
F131LOC_RS11995	COG1172	Belongs to the binding-protein-dependent transport system permease family
F131LOC_RS12000	COG1129	ABC transporter
F131LOC_RS12010	COG1879	ABC-type sugar transport system periplasmic component
F131LOC_RS12015	COG0671	phosphoesterase, PA-phosphatase related
F131LOC_RS12020	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F131LOC_RS12040	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
F131LOC_RS12045	COG1301	dicarboxylic acid transport
F131LOC_RS12050	COG0625	glutathione transferase activity
F131LOC_RS12055	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
F131LOC_RS12060	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
F131LOC_RS12065	COG0259	pyridoxamine-phosphate oxidase activity
F131LOC_RS12070	COG3895	Periplasmic Protein
F131LOC_RS12075	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
F131LOC_RS12090	COG3313	Fe-S protein
F131LOC_RS12095	COG0346	lactoylglutathione lyase activity
F131LOC_RS12100	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
F131LOC_RS12105	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
F131LOC_RS12110	COG0791	NLP P60 protein
F131LOC_RS12120	COG1609	Transcriptional regulator
F131LOC_RS12125	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
F131LOC_RS12130	COG0307	riboflavin synthase, alpha
F131LOC_RS12135	COG0534	Mate efflux family protein
F131LOC_RS12145	COG0439	Biotin carboxylase
F131LOC_RS12160	COG3665	Urea carboxylase-associated protein
F131LOC_RS12165	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
F131LOC_RS12165	COG1116	anion transmembrane transporter activity
F131LOC_RS12190	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
F131LOC_RS12195	COG1408	metallophosphoesterase
F131LOC_RS12205	COG0561	phosphatase activity
F131LOC_RS12210	COG2076	Multidrug Resistance protein
F131LOC_RS12215	COG1301	dicarboxylic acid transport
F131LOC_RS12225	COG0604	alcohol dehydrogenase
F131LOC_RS12235	COG0604	alcohol dehydrogenase
F131LOC_RS12240	COG0477	Major facilitator Superfamily
F131LOC_RS12255	COG2197	response regulator
F131LOC_RS12260	COG3850	Histidine kinase
F131LOC_RS12265	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
F131LOC_RS12265	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
F131LOC_RS12270	COG3062	negative regulation of establishment of protein localization
F131LOC_RS12275	COG0243	molybdopterin cofactor binding
F131LOC_RS12280	COG0437	4 iron, 4 sulfur cluster binding
F131LOC_RS12285	COG0348	domain, Protein
F131LOC_RS12290	COG3043	anaerobic respiration
F131LOC_RS12295	COG3005	denitrification pathway
F131LOC_RS12300	COG3088	subunit of a heme lyase
F131LOC_RS12300	COG4235	cytochrome complex assembly
F131LOC_RS12305	COG3088	subunit of a heme lyase
F131LOC_RS12305	COG4235	cytochrome complex assembly
F131LOC_RS12310	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F131LOC_RS12315	COG1138	Cytochrome C-type biogenesis protein
F131LOC_RS12320	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
F131LOC_RS12325	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
F131LOC_RS12330	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
F131LOC_RS12335	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
F131LOC_RS12340	COG4133	protoheme IX ABC transporter activity
F131LOC_RS12345	COG4235	cytochrome complex assembly
F131LOC_RS12350	COG3088	subunit of a heme lyase
F131LOC_RS12355	COG1138	Cytochrome C-type biogenesis protein
F131LOC_RS12360	COG3301	Polysulphide reductase, NrfD
F131LOC_RS12365	COG0437	4 iron, 4 sulfur cluster binding
F131LOC_RS12370	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
F131LOC_RS12375	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
F131LOC_RS12385	COG2382	esterase
F131LOC_RS12415	COG4238	major outer membrane lipoprotein
F131LOC_RS12420	COG1376	ErfK ybiS ycfS ynhG family protein
F131LOC_RS12420	COG1388	LysM domain
F131LOC_RS12425	COG2166	iron-sulfur cluster assembly
F131LOC_RS12430	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
F131LOC_RS12435	COG0719	Fe-S assembly protein
F131LOC_RS12440	COG0396	ATPase activity
F131LOC_RS12445	COG0719	Fe-S assembly protein
F131LOC_RS12450	COG0316	Belongs to the HesB IscA family
F131LOC_RS12460	COG2050	protein possibly involved in aromatic compounds catabolism
F131LOC_RS12465	COG0247	lactate metabolic process
F131LOC_RS12465	COG0277	FAD linked oxidase domain protein
F131LOC_RS12470	COG0628	permease
F131LOC_RS12480	COG1477	protein flavinylation
F131LOC_RS12485	COG0574	Belongs to the PEP-utilizing enzyme family
F131LOC_RS12485	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
F131LOC_RS12490	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
F131LOC_RS12495	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
F131LOC_RS12500	COG3720	iron ion transport
F131LOC_RS12505	COG4558	Periplasmic binding protein
F131LOC_RS12510	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F131LOC_RS12515	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
F131LOC_RS12520	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
F131LOC_RS12530	COG0095	Lipoate-protein ligase
F131LOC_RS12535	COG0791	NLP P60 protein
F131LOC_RS12540	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
F131LOC_RS12545	COG0386	Belongs to the glutathione peroxidase family
F131LOC_RS12550	COG4139	cobalamin transport
F131LOC_RS12555	COG2226	methyltransferase
F131LOC_RS12575	COG1940	carbohydrate kinase activity
F131LOC_RS12580	COG4591	ABC-type transport system involved in lipoprotein release permease component
F131LOC_RS12585	COG1136	(ABC) transporter
F131LOC_RS12590	COG4591	ABC-type transport system involved in lipoprotein release permease component
F131LOC_RS12595	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
F131LOC_RS12610	COG0443	Heat shock 70 kDa protein
F131LOC_RS12615	COG1309	transcriptional regulator
F131LOC_RS12625	COG2814	Major facilitator Superfamily
F131LOC_RS12630	COG3134	Outer membrane lipoprotein
F131LOC_RS12635	COG1252	NADH dehydrogenase
F131LOC_RS12640	COG3150	esterase
F131LOC_RS12645	COG1472	Belongs to the glycosyl hydrolase 3 family
F131LOC_RS12655	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
F131LOC_RS12665	COG0537	adenosine 5'-monophosphoramidase activity
F131LOC_RS12670	COG0477	Major facilitator Superfamily
F131LOC_RS12680	COG1263	PTS System
F131LOC_RS12680	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F131LOC_RS12685	COG0084	hydrolase, TatD family'
F131LOC_RS12690	COG0470	DNA polymerase III
F131LOC_RS12695	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
F131LOC_RS12700	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
F131LOC_RS12705	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
F131LOC_RS12710	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F131LOC_RS12715	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F131LOC_RS12725	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
F131LOC_RS12730	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
F131LOC_RS12735	COG0416	fatty acid biosynthetic process
F131LOC_RS12740	COG0333	Belongs to the bacterial ribosomal protein bL32 family
F131LOC_RS12745	COG1399	metal-binding, possibly nucleic acid-binding protein
F131LOC_RS12750	COG0424	maF-like protein
F131LOC_RS12755	COG0564	pseudouridine synthase activity
F131LOC_RS12760	COG1530	ribonuclease E activity
F131LOC_RS12770	COG0418	dihydroorotase activity
F131LOC_RS12790	COG3038	cytochrome b561
F131LOC_RS12795	COG2353	YceI-like domain
F131LOC_RS12800	COG1054	Belongs to the UPF0176 family
F131LOC_RS12805	COG1902	pentaerythritol trinitrate reductase activity
F131LOC_RS12815	COG1560	Kdo2-lipid A biosynthetic process
F131LOC_RS12820	COG2943	transferase activity, transferring hexosyl groups
F131LOC_RS12825	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
F131LOC_RS12840	COG0840	transmembrane signaling receptor activity
F131LOC_RS12860	COG1683	Conserved Protein
F131LOC_RS12865	COG0589	response to stress
F131LOC_RS12895	COG0670	Belongs to the BI1 family
F131LOC_RS12900	COG2920	part of a sulfur-relay system
F131LOC_RS12905	COG1254	Belongs to the acylphosphatase family
F131LOC_RS12910	COG3785	DNA binding
F131LOC_RS12915	COG1832	CoA-binding protein
F131LOC_RS12925	COG1803	Methylglyoxal synthase
F131LOC_RS12930	COG0210	DNA helicase
F131LOC_RS12935	COG3304	Inner membrane component domain
F131LOC_RS12940	COG1289	transmembrane transporter activity
F131LOC_RS12945	COG3070	regulator of competence-specific genes
F131LOC_RS12950	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
F131LOC_RS12965	COG1067	ATP-dependent peptidase activity
F131LOC_RS12970	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
F131LOC_RS12975	COG2979	Protein of unknown function (DUF533)
F131LOC_RS12980	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
F131LOC_RS12985	COG1012	belongs to the aldehyde dehydrogenase family
F131LOC_RS12990	COG1309	transcriptional regulator
F131LOC_RS12995	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
F131LOC_RS13010	COG1702	phosphate starvation-inducible protein PhoH
F131LOC_RS13020	COG1191	sigma factor activity
F131LOC_RS13060	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
F131LOC_RS13075	COG1677	Flagellar hook-basal body complex protein FliE
F131LOC_RS13090	COG1317	bacterial-type flagellum organization
F131LOC_RS13105	COG3144	bacterial-type flagellum assembly
F131LOC_RS13110	COG1580	Controls the rotational direction of flagella during chemotaxis
F131LOC_RS13155	COG3951	Flagellar rod assembly protein muramidase FlgJ
F131LOC_RS13155	COG1705	Flagellar rod assembly protein muramidase FlgJ
F131LOC_RS13160	COG1706	bacterial-type flagellum-dependent cell motility
F131LOC_RS13165	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
F131LOC_RS13175	COG4787	bacterial-type flagellum-dependent cell motility
F131LOC_RS13180	COG1749	Flagellar hook protein flgE
F131LOC_RS13185	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
F131LOC_RS13190	COG1558	bacterial-type flagellum-dependent cell motility
F131LOC_RS13195	COG1815	bacterial-type flagellum-dependent cell motility
F131LOC_RS13205	COG2747	anti-sigma28 factor FlgM
F131LOC_RS13220	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
F131LOC_RS13225	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
F131LOC_RS13235	COG0745	RESPONSE REGULATOR receiver
F131LOC_RS13240	COG2201	protein-glutamate methylesterase activity
F131LOC_RS13245	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
F131LOC_RS13250	COG0840	transmembrane signaling receptor activity
F131LOC_RS13255	COG0835	chemotaxis
F131LOC_RS13260	COG2198	Histidine kinase
F131LOC_RS13260	COG0643	Histidine kinase
F131LOC_RS13300	COG0840	transmembrane signaling receptor activity
F131LOC_RS13320	COG3459	Glycosyltransferase 36 associated
F131LOC_RS13325	COG1560	Kdo2-lipid A biosynthetic process
F131LOC_RS13335	COG5433	transposase activity
F131LOC_RS13390	COG2003	Belongs to the UPF0758 family
F131LOC_RS13410	COG3596	GTP binding
F131LOC_RS13450	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
F131LOC_RS13485	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
F131LOC_RS13505	COG0582	viral genome integration into host DNA
F131LOC_RS13525	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
F131LOC_RS13530	COG0322	excinuclease ABC activity
F131LOC_RS13535	COG2197	response regulator
F131LOC_RS13555	COG1113	amino acid transport
F131LOC_RS13595	COG0745	RESPONSE REGULATOR receiver
F131LOC_RS13625	COG2814	Major facilitator Superfamily
F131LOC_RS13655	COG1902	pentaerythritol trinitrate reductase activity
F131LOC_RS13670	COG0481	GTPase activity
F131LOC_RS13675	COG0659	secondary active sulfate transmembrane transporter activity
F131LOC_RS13685	COG0444	Belongs to the ABC transporter superfamily
F131LOC_RS13695	COG0601	transmembrane transport
F131LOC_RS13700	COG0747	negative chemotaxis
F131LOC_RS13710	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F131LOC_RS13720	COG4948	Mandelate Racemase Muconate Lactonizing
F131LOC_RS13740	COG0745	RESPONSE REGULATOR receiver
F131LOC_RS13745	COG5000	phosphorelay sensor kinase activity
F131LOC_RS13745	COG5002	protein histidine kinase activity
F131LOC_RS13760	COG0765	amino acid transport
F131LOC_RS13765	COG0765	amino acid transport
F131LOC_RS13770	COG1126	abc transporter atp-binding protein
F131LOC_RS13795	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
F131LOC_RS13800	COG2203	Gaf domain
F131LOC_RS13800	COG3706	GGDEF domain
F131LOC_RS13800	COG5001	Diguanylate cyclase
F131LOC_RS13800	COG4251	negative regulation of phosphorylation
F131LOC_RS13810	COG0626	cystathionine gamma-synthase activity
F131LOC_RS13815	COG1902	pentaerythritol trinitrate reductase activity
F131LOC_RS13820	COG0640	Transcriptional regulator
F131LOC_RS13825	COG1070	Carbohydrate kinase
F131LOC_RS13830	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F131LOC_RS13840	COG1172	Belongs to the binding-protein-dependent transport system permease family
F131LOC_RS13845	COG1172	Belongs to the binding-protein-dependent transport system permease family
F131LOC_RS13850	COG1129	ABC transporter
F131LOC_RS13860	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
F131LOC_RS13865	COG4807	Protein conserved in bacteria
F131LOC_RS13870	COG5464	transposase or invertase
F131LOC_RS13875	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
F131LOC_RS13875	COG1648	precorrin-2 dehydrogenase activity
F131LOC_RS13880	COG0243	molybdopterin cofactor binding
F131LOC_RS13885	COG2146	nitrite reductase [NAD(P)H] activity
F131LOC_RS13885	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
F131LOC_RS13890	COG1116	anion transmembrane transporter activity
F131LOC_RS13900	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
F131LOC_RS13905	COG3707	response regulator
F131LOC_RS13915	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
F131LOC_RS13920	COG1271	oxidase subunit
F131LOC_RS13925	COG1294	oxidase, subunit
F131LOC_RS13930	COG4890	Cyd operon protein YbgT
F131LOC_RS13935	COG2149	membrane
F131LOC_RS13945	COG3058	Necessary for formate dehydrogenase activity
F131LOC_RS13950	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F131LOC_RS13955	COG0519	Catalyzes the synthesis of GMP from XMP
F131LOC_RS13955	COG0518	GMP synthase (glutamine-hydrolyzing) activity
F131LOC_RS13980	COG4771	TonB-dependent receptor
F131LOC_RS13990	COG0488	(ABC) transporter
F131LOC_RS14005	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F131LOC_RS14005	COG1263	PTS System
F131LOC_RS14010	COG0366	Alpha amylase catalytic
F131LOC_RS14015	COG4575	ribosome binding
F131LOC_RS14020	COG1007	ATP synthesis coupled electron transport
F131LOC_RS14025	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F131LOC_RS14030	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
F131LOC_RS14035	COG0713	ATP synthesis coupled electron transport
F131LOC_RS14040	COG0839	Belongs to the complex I subunit 6 family
F131LOC_RS14045	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F131LOC_RS14050	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
F131LOC_RS14065	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
F131LOC_RS14070	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F131LOC_RS14070	COG0649	NAD binding
F131LOC_RS14075	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F131LOC_RS14085	COG0583	DNA-binding transcription factor activity
F131LOC_RS14090	COG0436	Aminotransferase
F131LOC_RS14095	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
F131LOC_RS14100	COG0490	domain, Protein
F131LOC_RS14100	COG0471	metal ion transport
F131LOC_RS14105	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F131LOC_RS14110	COG3013	Belongs to the UPF0304 family
F131LOC_RS14115	COG3092	negative regulation of chromosome organization
F131LOC_RS14120	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
F131LOC_RS14125	COG0857	belongs to the CobB CobQ family
F131LOC_RS14125	COG0280	phosphate acetyltransferase
F131LOC_RS14130	COG3739	integral membrane protein
F131LOC_RS14135	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
F131LOC_RS14140	COG0622	Phosphoesterase
F131LOC_RS14145	COG0625	glutathione transferase activity
F131LOC_RS14150	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
F131LOC_RS14155	COG1090	epimerase
F131LOC_RS14160	COG4598	ABC transporter
F131LOC_RS14165	COG4160	amino acid transport
F131LOC_RS14180	COG0163	prenyltransferase activity
F131LOC_RS14185	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
F131LOC_RS14190	COG1286	toxin biosynthetic process
F131LOC_RS14195	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
F131LOC_RS14200	COG0285	dihydrofolate synthase activity
F131LOC_RS14205	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
F131LOC_RS14210	COG0586	Pfam SNARE associated Golgi protein
F131LOC_RS14215	COG0101	tRNA pseudouridine synthase activity
F131LOC_RS14220	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
F131LOC_RS14225	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F131LOC_RS14230	COG0697	spore germination
F131LOC_RS14240	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F131LOC_RS14245	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F131LOC_RS14245	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
F131LOC_RS14255	COG3101	peptidyl-lysine hydroxylation
F131LOC_RS14260	COG0730	response to heat
F131LOC_RS14265	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
F131LOC_RS14270	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
F131LOC_RS14275	COG2890	protein-(glutamine-N5) methyltransferase activity
F131LOC_RS14280	COG2840	Smr protein MutS2
F131LOC_RS14285	COG2062	phosphohistidine phosphatase, SixA
F131LOC_RS14305	COG3188	usher protein
F131LOC_RS14315	COG1250	3-hydroxyacyl-CoA dehydrogenase
F131LOC_RS14315	COG1024	Enoyl-CoA hydratase
F131LOC_RS14320	COG0183	Belongs to the thiolase family
F131LOC_RS14330	COG1464	Belongs to the NlpA lipoprotein family
F131LOC_RS14345	COG3691	Protein conserved in bacteria
F131LOC_RS14350	COG2067	long-chain fatty acid transport protein
F131LOC_RS14355	COG1028	Short-chain dehydrogenase reductase Sdr
F131LOC_RS14360	COG0583	DNA-binding transcription factor activity
F131LOC_RS14365	COG0579	oxidoreductase
F131LOC_RS14375	COG2116	formate transmembrane transporter activity
F131LOC_RS14440	COG0513	Belongs to the DEAD box helicase family
F131LOC_RS14450	COG1120	ATPase activity
F131LOC_RS14455	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F131LOC_RS14460	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
F131LOC_RS14465	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F131LOC_RS14545	COG3866	Pectate lyase
F131LOC_RS14550	COG3266	domain, Protein
F131LOC_RS14560	COG0436	Aminotransferase
F131LOC_RS14565	COG4948	Mandelate Racemase Muconate Lactonizing
F131LOC_RS14575	COG3264	Mechanosensitive ion channel
F131LOC_RS14575	COG1511	domain protein
F131LOC_RS14585	COG0582	viral genome integration into host DNA
F131LOC_RS14600	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F131LOC_RS14615	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F131LOC_RS14620	COG1696	Membrane protein involved in D-alanine export
F131LOC_RS14645	COG1447	Phosphotransferase system cellobiose-specific component IIA
F131LOC_RS14660	COG3842	ATPase activity
F131LOC_RS14665	COG2076	Multidrug Resistance protein
F131LOC_RS14670	COG2076	Multidrug Resistance protein
F131LOC_RS14675	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
F131LOC_RS14680	COG0726	polysaccharide deacetylase
F131LOC_RS14685	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
F131LOC_RS14685	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F131LOC_RS14690	COG0463	Glycosyl transferase, family 2
F131LOC_RS14695	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
F131LOC_RS14705	COG2203	Gaf domain
F131LOC_RS14705	COG4251	negative regulation of phosphorylation
F131LOC_RS14705	COG5001	Diguanylate cyclase
F131LOC_RS14705	COG3706	GGDEF domain
F131LOC_RS14710	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
F131LOC_RS14715	COG2501	S4 domain
F131LOC_RS14720	COG0215	cysteine-tRNA ligase activity
F131LOC_RS14730	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
F131LOC_RS14735	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
F131LOC_RS14740	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
F131LOC_RS14745	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
F131LOC_RS14750	COG0814	amino acid
F131LOC_RS14755	COG1760	l-serine dehydratase
F131LOC_RS14775	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
F131LOC_RS14780	COG0581	inorganic phosphate transmembrane transporter activity
F131LOC_RS14785	COG0573	inorganic phosphate transmembrane transporter activity
F131LOC_RS14790	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
F131LOC_RS14810	COG1764	response to oxidative stress
F131LOC_RS14815	COG1846	Transcriptional regulator
F131LOC_RS14820	COG2239	Acts as a magnesium transporter
F131LOC_RS14825	COG1724	mRNA binding
F131LOC_RS14830	COG1598	PFAM Uncharacterised protein family UPF0150
F131LOC_RS14845	COG1609	Transcriptional regulator
F131LOC_RS14850	COG4580	involved in the transport of maltose and maltodextrins
F131LOC_RS14855	COG3842	ATPase activity
F131LOC_RS14860	COG2182	Extracellular solute-binding protein
F131LOC_RS14865	COG1175	transmembrane transport
F131LOC_RS14870	COG3833	ABC-type maltose transport systems, permease component
F131LOC_RS14875	COG3867	Arabinogalactan endo-beta-1,4-galactanase
F131LOC_RS14880	COG1874	Beta-galactosidase
F131LOC_RS14895	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
F131LOC_RS14900	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F131LOC_RS14905	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F131LOC_RS14910	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F131LOC_RS14915	COG0477	Major facilitator Superfamily
F131LOC_RS14920	COG2205	protein histidine kinase activity
F131LOC_RS14925	COG0745	RESPONSE REGULATOR receiver
F131LOC_RS14940	COG0435	Glutathione S-transferase
F131LOC_RS14945	COG0826	peptidase U32
F131LOC_RS14950	COG1597	lipid kinase activity
F131LOC_RS14955	COG3223	Belongs to the PsiE family
F131LOC_RS14965	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
F131LOC_RS14970	COG1064	alcohol dehydrogenase
F131LOC_RS14975	COG5001	Diguanylate cyclase
F131LOC_RS15015	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
F131LOC_RS15040	COG3423	Transcriptional regulator
F131LOC_RS15060	COG3657	addiction module killer protein
F131LOC_RS15080	COG0667	Aldo Keto reductase
F131LOC_RS15085	COG0519	Catalyzes the synthesis of GMP from XMP
F131LOC_RS15085	COG0518	GMP synthase (glutamine-hydrolyzing) activity
F131LOC_RS15090	COG0516	GMP reductase activity
F131LOC_RS15090	COG0517	IMP dehydrogenase activity
F131LOC_RS15095	COG1570	exodeoxyribonuclease VII activity
F131LOC_RS15110	COG1645	bacterial-type flagellum-dependent swarming motility
F131LOC_RS15125	COG1160	GTP binding
F131LOC_RS15130	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F131LOC_RS15135	COG2976	Protein conserved in bacteria
F131LOC_RS15140	COG0124	histidyl-tRNA synthetase
F131LOC_RS15145	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
F131LOC_RS15150	COG1426	Protein conserved in bacteria
F131LOC_RS15160	COG0820	rRNA (adenine-C2-)-methyltransferase activity
F131LOC_RS15165	COG0105	UTP biosynthetic process
F131LOC_RS15170	COG2190	(PTS) system
F131LOC_RS15170	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F131LOC_RS15170	COG1263	PTS System
F131LOC_RS15175	COG1486	melibiose metabolic process
F131LOC_RS15180	COG2897	thiosulfate sulfurtransferase activity
F131LOC_RS15185	COG1737	Transcriptional regulator
F131LOC_RS15195	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
F131LOC_RS15200	COG2975	iron-sulfur cluster assembly
F131LOC_RS15205	COG0633	Ferredoxin
F131LOC_RS15210	COG0443	Heat shock 70 kDa protein
F131LOC_RS15215	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
F131LOC_RS15220	COG0316	Belongs to the HesB IscA family
F131LOC_RS15225	COG0822	iron-sulfur transferase activity
F131LOC_RS15230	COG1104	cysteine desulfurase activity
F131LOC_RS15235	COG1959	2 iron, 2 sulfur cluster binding
F131LOC_RS15240	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
F131LOC_RS15245	COG0483	inositol monophosphate 1-phosphatase activity
F131LOC_RS15255	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F131LOC_RS15260	COG1120	ATPase activity
F131LOC_RS15270	COG0840	transmembrane signaling receptor activity
F131LOC_RS15280	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
F131LOC_RS15285	COG3683	transport system, periplasmic component
F131LOC_RS15290	COG2814	Major facilitator Superfamily
F131LOC_RS15295	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
F131LOC_RS15300	COG1017	nitric oxide dioxygenase activity
F131LOC_RS15300	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
F131LOC_RS15310	COG4677	pectinesterase activity
F131LOC_RS15315	COG0347	Belongs to the P(II) protein family
F131LOC_RS15320	COG2204	response regulator
F131LOC_RS15325	COG3170	Tfp pilus assembly protein FimV
F131LOC_RS15330	COG2205	protein histidine kinase activity
F131LOC_RS15335	COG0047	phosphoribosylformylglycinamidine synthase activity
F131LOC_RS15335	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
F131LOC_RS15340	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
F131LOC_RS15350	COG0560	Phosphoserine phosphatase
F131LOC_RS15355	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
F131LOC_RS15365	COG3287	FIST C domain
F131LOC_RS15365	COG2200	EAL domain
F131LOC_RS15365	COG2199	diguanylate cyclase activity
F131LOC_RS15385	COG2274	protein secretion by the type I secretion system
F131LOC_RS15390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F131LOC_RS15400	COG2200	EAL domain
F131LOC_RS15405	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
F131LOC_RS15410	COG0736	holo-[acyl-carrier-protein] synthase activity
F131LOC_RS15415	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
F131LOC_RS15420	COG1381	Involved in DNA repair and RecF pathway recombination
F131LOC_RS15425	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
F131LOC_RS15430	COG0571	ribonuclease III activity
F131LOC_RS15440	COG0481	GTPase activity
F131LOC_RS15455	COG3026	antisigma factor binding
F131LOC_RS15470	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
F131LOC_RS15475	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
F131LOC_RS15480	COG0513	Belongs to the DEAD box helicase family
F131LOC_RS15485	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
F131LOC_RS15490	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
F131LOC_RS15505	COG2819	hydrolase of the alpha beta superfamily
F131LOC_RS15510	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
F131LOC_RS15535	COG1902	pentaerythritol trinitrate reductase activity
F131LOC_RS15540	COG0667	Aldo Keto reductase
F131LOC_RS15555	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
F131LOC_RS15560	COG4208	sulfate ABC transporter
F131LOC_RS15570	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
F131LOC_RS15575	COG3835	regulator
F131LOC_RS15580	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F131LOC_RS15585	COG0232	Belongs to the dGTPase family. Type 2 subfamily
F131LOC_RS15590	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
F131LOC_RS15595	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
F131LOC_RS15605	COG0316	Belongs to the HesB IscA family
F131LOC_RS15610	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
F131LOC_RS15615	COG0625	glutathione transferase activity
F131LOC_RS15620	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F131LOC_RS15630	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F131LOC_RS15635	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
F131LOC_RS15640	COG1120	ATPase activity
F131LOC_RS15645	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
F131LOC_RS15650	COG1643	Atp-dependent helicase
F131LOC_RS15655	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
F131LOC_RS15660	COG1489	DNA binding
F131LOC_RS15670	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
F131LOC_RS15680	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
F131LOC_RS15685	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
F131LOC_RS15690	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
F131LOC_RS15695	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
F131LOC_RS15700	COG0842	Transport permease protein
F131LOC_RS15705	COG1131	(ABC) transporter
F131LOC_RS15710	COG0288	reversible hydration of carbon dioxide
F131LOC_RS15725	COG3842	ATPase activity
F131LOC_RS15740	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
F131LOC_RS15745	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
F131LOC_RS15750	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
F131LOC_RS15755	COG1780	Probably involved in ribonucleotide reductase function
F131LOC_RS15765	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
F131LOC_RS15780	COG0328	RNA-DNA hybrid ribonuclease activity
F131LOC_RS15785	COG2226	methyltransferase
F131LOC_RS15790	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F131LOC_RS15795	COG1388	LysM domain
F131LOC_RS15795	COG0741	lytic transglycosylase activity
F131LOC_RS15800	COG3021	interspecies interaction between organisms
F131LOC_RS15835	COG0542	response to heat
F131LOC_RS15845	COG0564	pseudouridine synthase activity
F131LOC_RS15850	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F131LOC_RS15855	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
F131LOC_RS15860	COG0077	Prephenate dehydratase
F131LOC_RS15860	COG1605	Chorismate mutase
F131LOC_RS15865	COG1605	Chorismate mutase
F131LOC_RS15865	COG0287	Prephenate dehydrogenase
F131LOC_RS15870	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
F131LOC_RS15875	COG3279	Response regulator of the LytR AlgR family
F131LOC_RS15885	COG2264	protein methyltransferase activity
F131LOC_RS15890	COG0335	large ribosomal subunit rRNA binding
F131LOC_RS15895	COG0336	Belongs to the RNA methyltransferase TrmD family
F131LOC_RS15900	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
F131LOC_RS15905	COG0228	four-way junction DNA binding
F131LOC_RS15910	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
F131LOC_RS15915	COG4137	Cytochrome C assembly protein
F131LOC_RS15920	COG1854	S-ribosylhomocysteine lyase activity
F131LOC_RS15925	COG2918	glutathione biosynthetic process
F131LOC_RS15930	COG1238	metal cluster binding
F131LOC_RS15935	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F131LOC_RS15960	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
F131LOC_RS15970	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
F131LOC_RS15975	COG2137	regulation of response to DNA damage stimulus
F131LOC_RS15980	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
F131LOC_RS15985	COG1546	Belongs to the CinA family
F131LOC_RS16010	COG2814	Major facilitator Superfamily
F131LOC_RS16015	COG0583	DNA-binding transcription factor activity
F131LOC_RS16020	COG2999	glutathione oxidoreductase activity
F131LOC_RS16065	COG3209	COG3209 Rhs family protein
F131LOC_RS16075	COG3209	COG3209 Rhs family protein
F131LOC_RS16115	COG3209	COG3209 Rhs family protein
F131LOC_RS16140	COG3501	Rhs element vgr protein
F131LOC_RS16175	COG3829	transcription factor binding
F131LOC_RS16280	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
F131LOC_RS16285	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
F131LOC_RS16300	COG1073	alpha beta
F131LOC_RS16305	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
F131LOC_RS16310	COG2195	Cleaves the N-terminal amino acid of tripeptides
F131LOC_RS16315	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
F131LOC_RS16325	COG2226	methyltransferase
F131LOC_RS16330	COG3034	peptidoglycan biosynthetic process
F131LOC_RS16335	COG0121	glutamine amidotransferase
F131LOC_RS16340	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
F131LOC_RS16345	COG1960	acyl-CoA dehydrogenase activity
F131LOC_RS16355	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
F131LOC_RS16360	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
F131LOC_RS16420	COG3501	Rhs element vgr protein
F131LOC_RS16425	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
F131LOC_RS16430	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
F131LOC_RS16435	COG0235	Class ii aldolase
F131LOC_RS16440	COG0436	Aminotransferase
F131LOC_RS16450	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
F131LOC_RS16460	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
F131LOC_RS16470	COG0765	amino acid transport
F131LOC_RS16515	COG4175	Glycine betaine
F131LOC_RS16520	COG4176	ABC-type proline glycine betaine transport system permease component
F131LOC_RS16525	COG2113	Glycine betaine
F131LOC_RS16530	COG0596	Alpha beta hydrolase
F131LOC_RS16540	COG2706	6-phosphogluconolactonase activity
F131LOC_RS16545	COG2814	Major facilitator Superfamily
F131LOC_RS16550	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
F131LOC_RS16560	COG1846	Transcriptional regulator
F131LOC_RS16565	COG1566	PFAM secretion protein HlyD family protein
F131LOC_RS16570	COG2814	Major facilitator Superfamily
F131LOC_RS16575	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
F131LOC_RS16585	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F131LOC_RS16590	COG3118	belongs to the thioredoxin family
F131LOC_RS16595	COG3148	PFAM DTW domain containing protein
F131LOC_RS16600	COG0045	succinate-CoA ligase (ADP-forming) activity
F131LOC_RS16600	COG1042	CoA-binding domain protein
F131LOC_RS16600	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F131LOC_RS16605	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
F131LOC_RS16610	COG0477	Major facilitator Superfamily
F131LOC_RS16645	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
F131LOC_RS16650	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
F131LOC_RS16655	COG2011	ABC-type metal ion transport system permease component
F131LOC_RS16660	COG1464	Belongs to the NlpA lipoprotein family
F131LOC_RS16670	COG1720	tRNA m6t6A37 methyltransferase activity
F131LOC_RS16675	COG0442	prolyl-tRNA aminoacylation
F131LOC_RS16685	COG4942	peptidase
F131LOC_RS16685	COG1388	LysM domain
F131LOC_RS16690	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
F131LOC_RS16695	COG0585	pseudouridine synthase activity
F131LOC_RS16700	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
F131LOC_RS16705	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
F131LOC_RS16710	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
F131LOC_RS16720	COG0765	amino acid transport
F131LOC_RS16725	COG1126	abc transporter atp-binding protein
F131LOC_RS16735	COG0529	Catalyzes the synthesis of activated sulfate
F131LOC_RS16740	COG2895	sulfate adenylyltransferase (ATP) activity
F131LOC_RS16745	COG0175	sulfate reduction
F131LOC_RS16750	COG1648	precorrin-2 dehydrogenase activity
F131LOC_RS16750	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
F131LOC_RS16755	COG0175	sulfate reduction
F131LOC_RS16760	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
F131LOC_RS16765	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
F131LOC_RS16775	COG2200	EAL domain
F131LOC_RS16795	COG0720	synthase
F131LOC_RS16800	COG0602	queuosine metabolic process
F131LOC_RS16805	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F131LOC_RS16820	COG1028	Short-chain dehydrogenase reductase Sdr
F131LOC_RS16825	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
F131LOC_RS16835	COG0583	DNA-binding transcription factor activity
F131LOC_RS16850	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
F131LOC_RS16865	COG0148	phosphopyruvate hydratase activity
F131LOC_RS16870	COG0504	CTP synthase activity
F131LOC_RS16875	COG3956	TIGRFAM MazG family protein
F131LOC_RS16880	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
F131LOC_RS16885	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
F131LOC_RS16895	COG1929	Belongs to the glycerate kinase type-1 family
F131LOC_RS16900	COG2084	Dehydrogenase
F131LOC_RS16910	COG4948	Mandelate Racemase Muconate Lactonizing
F131LOC_RS16915	COG4948	Mandelate Racemase Muconate Lactonizing
F131LOC_RS16920	COG2271	Major facilitator Superfamily
F131LOC_RS16925	COG2721	sulfolactate sulfo-lyase activity
F131LOC_RS16930	COG0840	transmembrane signaling receptor activity
F131LOC_RS16945	COG3530	Putative quorum-sensing-regulated virulence factor
F131LOC_RS16950	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
F131LOC_RS16955	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
F131LOC_RS16955	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
F131LOC_RS16960	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
F131LOC_RS16965	COG3025	triphosphatase activity
F131LOC_RS16970	COG4991	sh3 domain protein
F131LOC_RS16975	COG0617	tRNA 3'-terminal CCA addition
F131LOC_RS16980	COG1968	undecaprenyl-diphosphatase activity
F131LOC_RS16985	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
F131LOC_RS16990	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
F131LOC_RS16995	COG0840	transmembrane signaling receptor activity
F131LOC_RS17000	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
F131LOC_RS17005	COG2105	PFAM AIG2 family protein
F131LOC_RS17010	COG2911	Protein conserved in bacteria
F131LOC_RS17015	COG0729	surface antigen
F131LOC_RS17020	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F131LOC_RS17025	COG1253	flavin adenine dinucleotide binding
F131LOC_RS17035	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
F131LOC_RS17040	COG1218	3'(2'),5'-bisphosphate nucleotidase
F131LOC_RS17045	COG0737	Belongs to the 5'-nucleotidase family
F131LOC_RS17050	COG1733	regulation of RNA biosynthetic process
F131LOC_RS17065	COG3961	Belongs to the TPP enzyme family
F131LOC_RS17070	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
F131LOC_RS17075	COG0545	Peptidyl-prolyl cis-trans isomerase
F131LOC_RS17080	COG3061	Opacity-associated protein A
F131LOC_RS17090	COG0359	binds to the 23S rRNA
F131LOC_RS17095	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
F131LOC_RS17100	COG2965	DNA replication, synthesis of RNA primer
F131LOC_RS17105	COG0360	Binds together with S18 to 16S ribosomal RNA
F131LOC_RS17110	COG1073	alpha beta
F131LOC_RS17115	COG0840	transmembrane signaling receptor activity
F131LOC_RS17120	COG1690	Belongs to the RtcB family
F131LOC_RS17125	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
F131LOC_RS17135	COG3766	membrane
F131LOC_RS17140	COG0840	transmembrane signaling receptor activity
F131LOC_RS17145	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F131LOC_RS17150	COG0557	exoribonuclease II activity
F131LOC_RS17155	COG1959	2 iron, 2 sulfur cluster binding
F131LOC_RS17160	COG0840	transmembrane signaling receptor activity
F131LOC_RS17170	COG2805	Type II/IV secretion system protein
F131LOC_RS17175	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
F131LOC_RS17180	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
F131LOC_RS17185	COG0762	integral membrane protein
F131LOC_RS17190	COG1872	DUF167
F131LOC_RS17195	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
F131LOC_RS17200	COG0635	Involved in the biosynthesis of porphyrin-containing compound
F131LOC_RS17220	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
F131LOC_RS17235	COG3385	transposase activity
F131LOC_RS17245	COG2153	protein acetylation
F131LOC_RS17250	COG0477	Major facilitator Superfamily
F131LOC_RS17255	COG0318	PFAM AMP-dependent synthetase and ligase
F131LOC_RS17255	COG0204	Acyl-transferase
F131LOC_RS17265	COG2186	Transcriptional regulator
F131LOC_RS17270	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
F131LOC_RS17275	COG2723	6-phospho-beta-galactosidase activity
F131LOC_RS17280	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
F131LOC_RS17285	COG1447	Phosphotransferase system cellobiose-specific component IIA
F131LOC_RS17290	COG1609	Transcriptional regulator
F131LOC_RS17295	COG1396	sequence-specific DNA binding
F131LOC_RS17310	COG0583	DNA-binding transcription factor activity
F131LOC_RS17315	COG0583	DNA-binding transcription factor activity
F131LOC_RS17340	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
F131LOC_RS17350	COG2124	cytochrome p450
F131LOC_RS17365	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
F131LOC_RS17375	COG1522	sequence-specific DNA binding
F131LOC_RS17385	COG1448	Aminotransferase
F131LOC_RS17390	COG1451	nucleotide metabolic process
F131LOC_RS17410	COG1518	maintenance of DNA repeat elements
F131LOC_RS17415	COG1203	CRISPR-associated helicase, Cas3
F131LOC_RS17440	COG0432	Pfam Uncharacterised protein family UPF0047
F131LOC_RS17450	COG0629	single-stranded DNA binding
F131LOC_RS17475	COG0395	ABC-type sugar transport system, permease component
F131LOC_RS17480	COG1175	transmembrane transport
F131LOC_RS17485	COG3842	ATPase activity
F131LOC_RS17490	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
F131LOC_RS17510	COG2971	BadF BadG BcrA BcrD
F131LOC_RS17520	COG1121	(ABC) transporter
F131LOC_RS17525	COG1108	ABC-type Mn2 Zn2 transport systems permease components
F131LOC_RS17530	COG0803	Belongs to the bacterial solute-binding protein 9 family
F131LOC_RS17545	COG4245	von Willebrand factor, type A
F131LOC_RS17560	COG4245	von Willebrand factor, type A
F131LOC_RS17575	COG1358	cellular component organization or biogenesis
F131LOC_RS17630	COG1349	DNA-binding transcription factor activity
F131LOC_RS17635	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
F131LOC_RS17640	COG3395	kinase activity
F131LOC_RS17645	COG1454	alcohol dehydrogenase
F131LOC_RS17650	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F131LOC_RS17665	COG2731	YhcH YjgK YiaL family protein
F131LOC_RS17670	COG1028	Short-chain dehydrogenase reductase Sdr
F131LOC_RS17675	COG1609	Transcriptional regulator
F131LOC_RS17680	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
F131LOC_RS17695	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
F131LOC_RS17700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F131LOC_RS17705	COG0765	amino acid transport
F131LOC_RS17710	COG1126	abc transporter atp-binding protein
F131LOC_RS17715	COG0765	amino acid transport
F131LOC_RS17720	COG3112	Uncharacterised protein family (UPF0231)
F131LOC_RS17740	COG0640	Transcriptional regulator
F131LOC_RS17745	COG4771	TonB-dependent receptor
F131LOC_RS17750	COG2207	Transcriptional regulator
F131LOC_RS17755	COG2079	MmgE PrpD family protein
F131LOC_RS17765	COG1073	alpha beta
F131LOC_RS17770	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F131LOC_RS17775	COG0508	dehydrogenase complex catalyzes the overall conversion of
F131LOC_RS17780	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
F131LOC_RS17790	COG1113	amino acid transport
F131LOC_RS17795	COG2211	Major facilitator Superfamily
F131LOC_RS17800	COG3940	Belongs to the glycosyl hydrolase 43 family
F131LOC_RS17805	COG3725	Membrane protein required for beta-lactamase induction
F131LOC_RS17810	COG3023	N-Acetylmuramoyl-L-alanine amidase
F131LOC_RS17815	COG3248	Nucleoside-binding outer membrane protein
F131LOC_RS17820	COG0157	Belongs to the NadC ModD family
F131LOC_RS17825	COG4969	Belongs to the N-Me-Phe pilin family
F131LOC_RS17830	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
F131LOC_RS17835	COG1459	type II secretion system
F131LOC_RS17840	COG0516	GMP reductase activity
F131LOC_RS17845	COG0237	dephospho-CoA kinase activity
F131LOC_RS17850	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
F131LOC_RS17855	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
F131LOC_RS17860	COG0494	nUDIX hydrolase
F131LOC_RS17865	COG0653	protein targeting
F131LOC_RS17880	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
F131LOC_RS17885	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
F131LOC_RS17890	COG0849	cell division
F131LOC_RS17895	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
F131LOC_RS17900	COG1181	Belongs to the D-alanine--D-alanine ligase family
F131LOC_RS17905	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
F131LOC_RS17910	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
F131LOC_RS17915	COG0772	Belongs to the SEDS family
F131LOC_RS17920	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
F131LOC_RS17925	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
F131LOC_RS17930	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
F131LOC_RS17935	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
F131LOC_RS17940	COG0768	penicillin binding
F131LOC_RS17945	COG3116	cell division
F131LOC_RS17950	COG0275	rRNA processing
F131LOC_RS17955	COG2001	Belongs to the MraZ family
F131LOC_RS17975	COG0028	Belongs to the TPP enzyme family
F131LOC_RS17980	COG1022	Amp-dependent synthetase and ligase
F131LOC_RS17985	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
F131LOC_RS17990	COG0473	3-isopropylmalate dehydrogenase activity
F131LOC_RS17995	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
F131LOC_RS18000	COG0066	3-isopropylmalate dehydratase activity
F131LOC_RS18020	COG0840	transmembrane signaling receptor activity
F131LOC_RS18040	COG4533	DNA binding
F131LOC_RS18045	COG4143	(ABC) transporter
F131LOC_RS18050	COG1178	ABC-type Fe3 transport system permease component
F131LOC_RS18055	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
F131LOC_RS18060	COG3507	Belongs to the glycosyl hydrolase 43 family
F131LOC_RS18065	COG0028	Belongs to the TPP enzyme family
F131LOC_RS18070	COG0440	acetolactate synthase activity
F131LOC_RS18075	COG0586	Pfam SNARE associated Golgi protein
F131LOC_RS18080	COG3706	GGDEF domain
F131LOC_RS18085	COG0417	DNA replication proofreading
F131LOC_RS18090	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
F131LOC_RS18095	COG0564	pseudouridine synthase activity
F131LOC_RS18100	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
F131LOC_RS18105	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
F131LOC_RS18110	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
F131LOC_RS18115	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
F131LOC_RS18120	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
F131LOC_RS18125	COG2967	ApaG domain
F131LOC_RS18130	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
F131LOC_RS18150	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
F131LOC_RS18155	COG3610	response to peptide
F131LOC_RS18160	COG2966	Psort location CytoplasmicMembrane, score
F131LOC_RS18180	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
F131LOC_RS18185	COG0505	Belongs to the CarA family
F131LOC_RS18190	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
F131LOC_RS18195	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
F131LOC_RS18200	COG1047	Peptidyl-prolyl cis-trans
F131LOC_RS18210	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
F131LOC_RS18215	COG0196	riboflavin kinase activity
F131LOC_RS18220	COG0268	Binds directly to 16S ribosomal RNA
F131LOC_RS18225	COG0583	DNA-binding transcription factor activity
F131LOC_RS18230	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
F131LOC_RS18235	COG0484	heat shock protein binding
F131LOC_RS18240	COG0443	Heat shock 70 kDa protein
F131LOC_RS18245	COG1584	GPR1 FUN34 yaaH family protein
F131LOC_RS18255	COG0521	Mo-molybdopterin cofactor biosynthetic process
F131LOC_RS18265	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
F131LOC_RS18270	COG3022	response to hydroperoxide
F131LOC_RS18280	COG0083	homoserine kinase activity
F131LOC_RS18295	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
F131LOC_RS18300	COG0745	RESPONSE REGULATOR receiver
F131LOC_RS18305	COG3045	CreA protein
F131LOC_RS18310	COG3708	Transcriptional regulator
F131LOC_RS18310	COG2207	Transcriptional regulator
F131LOC_RS18320	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
F131LOC_RS18325	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
F131LOC_RS18335	COG0488	(ABC) transporter
F131LOC_RS18340	COG0840	transmembrane signaling receptor activity
F131LOC_RS18345	COG0583	DNA-binding transcription factor activity
F131LOC_RS18350	COG0604	alcohol dehydrogenase
F131LOC_RS18355	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F131LOC_RS18360	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
F131LOC_RS18365	COG0583	DNA-binding transcription factor activity
F131LOC_RS18375	COG1279	arginine transmembrane transporter activity
F131LOC_RS18380	COG0668	transmembrane transport
F131LOC_RS18385	COG0191	fructose-bisphosphate aldolase activity
F131LOC_RS18390	COG0126	phosphoglycerate kinase activity
F131LOC_RS18395	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
F131LOC_RS18400	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
F131LOC_RS18405	COG0501	Belongs to the peptidase M48B family
F131LOC_RS18415	COG1166	arginine decarboxylase activity
F131LOC_RS18420	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
F131LOC_RS18425	COG3091	SprT-like family
F131LOC_RS18430	COG2356	endonuclease I
F131LOC_RS18435	COG1385	rRNA (uridine-N3-)-methyltransferase activity
F131LOC_RS18440	COG0189	ligase activity
F131LOC_RS18445	COG1678	Uncharacterized ACR, COG1678
F131LOC_RS18450	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
F131LOC_RS18455	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
F131LOC_RS18460	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
F131LOC_RS18465	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
F131LOC_RS18470	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
F131LOC_RS18475	COG0330	HflC and HflK could
F131LOC_RS18480	COG0330	HflC and HflK could
F131LOC_RS18485	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
F131LOC_RS18490	COG1923	regulation of RNA biosynthetic process
F131LOC_RS18495	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
F131LOC_RS18500	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
F131LOC_RS18505	COG0860	N-Acetylmuramoyl-L-alanine amidase
F131LOC_RS18510	COG0802	atpase or kinase
F131LOC_RS18515	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
F131LOC_RS18515	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
F131LOC_RS18520	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
F131LOC_RS18535	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
F131LOC_RS18550	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F131LOC_RS18560	COG1064	alcohol dehydrogenase
F131LOC_RS18580	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
F131LOC_RS18585	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F131LOC_RS18600	COG1011	Hydrolase
F131LOC_RS18605	COG2814	Major facilitator Superfamily
F131LOC_RS18625	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
F131LOC_RS18630	COG1162	GTPase activity
F131LOC_RS18635	COG0688	phosphatidylethanolamine metabolic process
F131LOC_RS18640	COG1511	domain protein
F131LOC_RS18640	COG3264	Mechanosensitive ion channel
F131LOC_RS18645	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
F131LOC_RS18650	COG1053	succinate dehydrogenase
F131LOC_RS18655	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
F131LOC_RS18660	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
F131LOC_RS18665	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
F131LOC_RS18670	COG3040	lipid binding
F131LOC_RS18685	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
F131LOC_RS18690	COG1509	lysine 2,3-aminomutase activity
F131LOC_RS18700	COG0166	Belongs to the GPI family
F131LOC_RS18705	COG0527	aspartate kinase activity
F131LOC_RS18715	COG0471	metal ion transport
F131LOC_RS18725	COG2207	Transcriptional regulator
F131LOC_RS18730	COG0646	methionine synthase
F131LOC_RS18730	COG1410	methionine synthase
F131LOC_RS18740	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
F131LOC_RS18750	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
F131LOC_RS18755	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
F131LOC_RS18785	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
F131LOC_RS18795	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
F131LOC_RS18800	COG0009	L-threonylcarbamoyladenylate synthase
F131LOC_RS18805	COG0551	DNA topoisomerase type I activity
F131LOC_RS18810	COG2922	Belongs to the Smg family
F131LOC_RS18815	COG0758	DNA mediated transformation
F131LOC_RS18820	COG0242	peptide deformylase activity
F131LOC_RS18825	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
F131LOC_RS18830	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
F131LOC_RS18830	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
F131LOC_RS18835	COG0569	domain protein
F131LOC_RS18840	COG1970	mechanosensitive ion channel activity
F131LOC_RS18845	COG3036	rescue of stalled ribosome
F131LOC_RS18850	COG0203	ribosomal protein L17
F131LOC_RS18855	COG0202	RNA polymerase activity
F131LOC_RS18860	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
F131LOC_RS18870	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
F131LOC_RS18875	COG0257	Belongs to the bacterial ribosomal protein bL36 family
F131LOC_RS18880	COG0201	protein transport
F131LOC_RS18885	COG0200	Binds to the 23S rRNA
F131LOC_RS18890	COG1841	ribosomal large subunit assembly
F131LOC_RS18895	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
F131LOC_RS18900	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
F131LOC_RS18905	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
F131LOC_RS18910	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
F131LOC_RS18915	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
F131LOC_RS18920	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
F131LOC_RS18925	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
F131LOC_RS18935	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
F131LOC_RS18940	COG0255	Belongs to the universal ribosomal protein uL29 family
F131LOC_RS18945	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
F131LOC_RS18950	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
F131LOC_RS18955	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
F131LOC_RS18960	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
F131LOC_RS18965	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
F131LOC_RS18975	COG0088	Forms part of the polypeptide exit tunnel
F131LOC_RS18980	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
F131LOC_RS18985	COG0051	transcription antitermination factor activity, RNA binding
F131LOC_RS18990	COG2193	ferroxidase activity
F131LOC_RS19000	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
F131LOC_RS19005	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
F131LOC_RS19010	COG0049	tRNA binding
F131LOC_RS19015	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
F131LOC_RS19020	COG2168	tRNA wobble position uridine thiolation
F131LOC_RS19025	COG2923	Belongs to the DsrF TusC family
F131LOC_RS19030	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
F131LOC_RS19035	COG2964	Protein conserved in bacteria
F131LOC_RS19045	COG0745	RESPONSE REGULATOR receiver
F131LOC_RS19050	COG0642	Histidine kinase
F131LOC_RS19055	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
F131LOC_RS19070	COG0545	Peptidyl-prolyl cis-trans isomerase
F131LOC_RS19075	COG2900	Belongs to the SlyX family
F131LOC_RS19080	COG1047	Peptidyl-prolyl cis-trans
F131LOC_RS19085	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
F131LOC_RS19090	COG0475	glutathione-regulated potassium exporter activity
F131LOC_RS19090	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
F131LOC_RS19095	COG2249	NAD(P)H dehydrogenase (quinone) activity
F131LOC_RS19100	COG0488	(ABC) transporter
F131LOC_RS19110	COG0429	hydrolase of the alpha beta-hydrolase fold
F131LOC_RS19115	COG3089	Belongs to the UPF0270 family
F131LOC_RS19120	COG3954	Phosphoribulokinase
F131LOC_RS19125	COG1765	OsmC-like protein
F131LOC_RS19130	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F131LOC_RS19165	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
F131LOC_RS19170	COG4608	Belongs to the ABC transporter superfamily
F131LOC_RS19175	COG0444	Belongs to the ABC transporter superfamily
F131LOC_RS19180	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F131LOC_RS19185	COG0601	transmembrane transport
F131LOC_RS19190	COG0747	negative chemotaxis
F131LOC_RS19195	COG4948	Mandelate Racemase Muconate Lactonizing
F131LOC_RS19200	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
F131LOC_RS19210	COG1648	precorrin-2 dehydrogenase activity
F131LOC_RS19210	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
F131LOC_RS19235	COG1473	amidohydrolase
F131LOC_RS19245	COG0546	phosphoglycolate phosphatase activity
F131LOC_RS19250	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
F131LOC_RS19265	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
F131LOC_RS19270	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
F131LOC_RS19275	COG4796	Type ii and iii secretion system protein
F131LOC_RS19300	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
F131LOC_RS19305	COG0494	nUDIX hydrolase
F131LOC_RS19315	COG1011	Hydrolase
F131LOC_RS19320	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
F131LOC_RS19325	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
F131LOC_RS19330	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
F131LOC_RS19355	COG2814	Major facilitator Superfamily
F131LOC_RS19360	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
F131LOC_RS19365	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
F131LOC_RS19370	COG0019	diaminopimelate decarboxylase activity
F131LOC_RS19375	COG4774	siderophore transport
F131LOC_RS19380	COG4264	IucA IucC family
F131LOC_RS19390	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
F131LOC_RS19415	COG0840	transmembrane signaling receptor activity
F131LOC_RS19425	COG2183	response to ionizing radiation
F131LOC_RS19430	COG1414	Transcriptional regulator
F131LOC_RS19460	COG1785	Belongs to the alkaline phosphatase family
F131LOC_RS19465	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F131LOC_RS19470	COG2267	carboxylic ester hydrolase activity
F131LOC_RS19475	COG1040	competence protein
F131LOC_RS19480	COG0316	Belongs to the HesB IscA family
F131LOC_RS19480	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
F131LOC_RS19485	COG1640	4-alpha-glucanotransferase
F131LOC_RS19490	COG0058	SHG alpha-glucan phosphorylase activity
F131LOC_RS19495	COG1349	DNA-binding transcription factor activity
F131LOC_RS19500	COG0705	Rhomboid family
F131LOC_RS19510	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F131LOC_RS19515	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
F131LOC_RS19520	COG3501	Rhs element vgr protein
F131LOC_RS19540	COG0058	SHG alpha-glucan phosphorylase activity
F131LOC_RS19545	COG0297	glycogen (starch) synthase activity
F131LOC_RS19550	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
F131LOC_RS19555	COG1523	belongs to the glycosyl hydrolase 13 family
F131LOC_RS19560	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
F131LOC_RS19565	COG3275	phosphorelay sensor kinase activity
F131LOC_RS19580	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
F131LOC_RS19585	COG2095	MarC family integral membrane protein
F131LOC_RS19590	COG2610	gluconate transmembrane transporter activity
F131LOC_RS19595	COG3265	gluconokinase activity
F131LOC_RS19600	COG1609	Transcriptional regulator
F131LOC_RS19605	COG1741	Belongs to the pirin family
F131LOC_RS19615	COG0247	lactate metabolic process
F131LOC_RS19620	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
F131LOC_RS19625	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
F131LOC_RS19630	COG2271	Major facilitator Superfamily
F131LOC_RS19635	COG0584	glycerophosphoryl diester phosphodiesterase
F131LOC_RS19640	COG0561	phosphatase activity
F131LOC_RS19645	COG2267	carboxylic ester hydrolase activity
F131LOC_RS19650	COG1280	lysine exporter protein (LysE YggA)
F131LOC_RS19655	COG1280	lysine exporter protein (LysE YggA)
F131LOC_RS19660	COG0514	ATP-dependent DNA helicase (RecQ)
F131LOC_RS19670	COG2050	protein possibly involved in aromatic compounds catabolism
F131LOC_RS19680	COG3180	Ammonia monooxygenase
F131LOC_RS19685	COG0598	Magnesium transport protein CorA
F131LOC_RS19690	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
F131LOC_RS19695	COG0210	DNA helicase
F131LOC_RS19700	COG1011	Hydrolase
F131LOC_RS19715	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
F131LOC_RS19725	COG1965	Belongs to the frataxin family
F131LOC_RS19730	COG2814	Major facilitator Superfamily
F131LOC_RS19740	COG0181	hydroxymethylbilane synthase activity
F131LOC_RS19745	COG1587	Uroporphyrinogen-III synthase
F131LOC_RS19750	COG2959	enzyme of heme biosynthesis
F131LOC_RS19755	COG3071	HemY protein
F131LOC_RS19760	COG1802	Transcriptional regulator
F131LOC_RS19780	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F131LOC_RS19785	COG4597	amino acid ABC transporter
F131LOC_RS19790	COG0765	amino acid transport
F131LOC_RS19795	COG1126	abc transporter atp-binding protein
F131LOC_RS19800	COG1473	amidohydrolase
F131LOC_RS19805	COG1126	abc transporter atp-binding protein
F131LOC_RS19810	COG0765	amino acid transport
F131LOC_RS19815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F131LOC_RS19820	COG0456	acetyltransferase
F131LOC_RS19825	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
F131LOC_RS19860	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
F131LOC_RS19870	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
F131LOC_RS19875	COG2244	polysaccharide biosynthetic process
F131LOC_RS19880	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
F131LOC_RS19885	COG0456	acetyltransferase
F131LOC_RS19890	COG1088	dTDP-glucose 4,6-dehydratase activity
F131LOC_RS19895	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
F131LOC_RS19900	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
F131LOC_RS19905	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
F131LOC_RS19910	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
F131LOC_RS19915	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
F131LOC_RS19920	COG3118	belongs to the thioredoxin family
F131LOC_RS19925	COG0513	Belongs to the DEAD box helicase family
F131LOC_RS19930	COG0248	Ppx GppA phosphatase
F131LOC_RS19935	COG0210	DNA helicase
F131LOC_RS19940	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
F131LOC_RS19945	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
F131LOC_RS19945	COG0506	proline dehydrogenase activity
F131LOC_RS19945	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
F131LOC_RS19960	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
F131LOC_RS19965	COG0583	DNA-binding transcription factor activity
F131LOC_RS20010	COG0129	dihydroxy-acid dehydratase activity
F131LOC_RS20020	COG3978	acetolactate synthase activity
F131LOC_RS20035	COG0606	chelatase, subunit chli
F131LOC_RS20040	COG3085	chromosome segregation
F131LOC_RS20045	COG0583	DNA-binding transcription factor activity
F131LOC_RS20050	COG1172	Belongs to the binding-protein-dependent transport system permease family
F131LOC_RS20055	COG1172	Belongs to the binding-protein-dependent transport system permease family
F131LOC_RS20060	COG1129	ABC transporter
F131LOC_RS20065	COG1879	ABC-type sugar transport system periplasmic component
F131LOC_RS20110	COG1739	Uncharacterized protein family UPF0029
F131LOC_RS20115	COG0006	proline dipeptidase activity
F131LOC_RS20120	COG1250	3-hydroxyacyl-CoA dehydrogenase
F131LOC_RS20120	COG1024	Enoyl-CoA hydratase
F131LOC_RS20125	COG0183	Belongs to the thiolase family
F131LOC_RS20135	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
F131LOC_RS20140	COG0250	Participates in transcription elongation, termination and antitermination
F131LOC_RS20150	COG0084	hydrolase, TatD family'
F131LOC_RS20155	COG0805	protein transport
F131LOC_RS20160	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
F131LOC_RS20165	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
F131LOC_RS20170	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
F131LOC_RS20180	COG2226	methyltransferase
F131LOC_RS20185	COG1322	Protein conserved in bacteria
F131LOC_RS20190	COG0165	Argininosuccinate lyase
F131LOC_RS20195	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
F131LOC_RS20200	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
F131LOC_RS20205	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F131LOC_RS20210	COG2188	Transcriptional regulator
F131LOC_RS20215	COG4948	Mandelate Racemase Muconate Lactonizing
F131LOC_RS20220	COG2190	(PTS) system
F131LOC_RS20220	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F131LOC_RS20220	COG1263	PTS System
F131LOC_RS20225	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
F131LOC_RS20240	COG0412	Dienelactone hydrolase
F131LOC_RS20245	COG0840	transmembrane signaling receptor activity
F131LOC_RS20250	COG0840	transmembrane signaling receptor activity
F131LOC_RS20255	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
F131LOC_RS20260	COG0583	DNA-binding transcription factor activity
F131LOC_RS20290	COG1045	serine acetyltransferase
F131LOC_RS20295	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
F131LOC_RS20300	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
F131LOC_RS20305	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F131LOC_RS20310	COG4942	peptidase
F131LOC_RS20315	COG2861	carbohydrate metabolic process
F131LOC_RS20320	COG1063	alcohol dehydrogenase
F131LOC_RS20325	COG0156	8-amino-7-oxononanoate synthase activity
F131LOC_RS20330	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F131LOC_RS20340	COG0859	PFAM glycosyl transferase family 9
F131LOC_RS20345	COG3307	-O-antigen
F131LOC_RS20360	COG0859	PFAM glycosyl transferase family 9
F131LOC_RS20365	COG0438	transferase activity, transferring glycosyl groups
F131LOC_RS20370	COG0515	serine threonine protein kinase
F131LOC_RS20375	COG0438	transferase activity, transferring glycosyl groups
F131LOC_RS20410	COG1519	Transferase
F131LOC_RS20415	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
F131LOC_RS20420	COG1442	glycosyl transferase family 8
F131LOC_RS20420	COG1216	Glycosyl transferase, family 2
F131LOC_RS20425	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
F131LOC_RS20435	COG0227	Belongs to the bacterial ribosomal protein bL28 family
F131LOC_RS20440	COG2003	Belongs to the UPF0758 family
F131LOC_RS20445	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
F131LOC_RS20450	COG0756	dUTP diphosphatase activity
F131LOC_RS20455	COG1309	transcriptional regulator
F131LOC_RS20460	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
F131LOC_RS20465	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
F131LOC_RS20470	COG4948	Mandelate Racemase Muconate Lactonizing
F131LOC_RS20475	COG4172	Belongs to the ABC transporter superfamily
F131LOC_RS20480	COG0747	negative chemotaxis
F131LOC_RS20485	COG0601	transmembrane transport
F131LOC_RS20490	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F131LOC_RS20505	COG1446	asparaginase
F131LOC_RS20510	COG0583	DNA-binding transcription factor activity
F131LOC_RS20515	COG1561	YicC-like family, N-terminal region
F131LOC_RS20525	COG3645	SOS response
F131LOC_RS20600	COG0628	permease
F131LOC_RS20605	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
F131LOC_RS20605	COG0456	acetyltransferase
F131LOC_RS20610	COG1304	FMN binding
F131LOC_RS20615	COG1012	belongs to the aldehyde dehydrogenase family
F131LOC_RS20625	COG3239	Fatty acid desaturase
F131LOC_RS20655	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F131LOC_RS20660	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
F131LOC_RS20665	COG3136	membrane protein required for alginate biosynthesis
F131LOC_RS20680	COG4677	pectinesterase activity
F131LOC_RS20685	COG2771	luxR family
F131LOC_RS20695	COG0137	argininosuccinate synthase activity
F131LOC_RS20705	COG1609	Transcriptional regulator
F131LOC_RS20705	COG2207	Transcriptional regulator
F131LOC_RS20710	COG4214	carbohydrate transport
F131LOC_RS20715	COG1129	ABC transporter
F131LOC_RS20720	COG4213	ABC transporter substrate-binding protein
F131LOC_RS20725	COG2115	Belongs to the xylose isomerase family
F131LOC_RS20730	COG1070	Carbohydrate kinase
F131LOC_RS20735	COG3274	enterobacterial common antigen metabolic process
F131LOC_RS20740	COG1012	belongs to the aldehyde dehydrogenase family
F131LOC_RS20745	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
F131LOC_RS20750	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
F131LOC_RS20755	COG0840	transmembrane signaling receptor activity
F131LOC_RS20765	COG3722	fumarate hydratase activity
F131LOC_RS20770	COG0246	Mannitol dehydrogenase
F131LOC_RS20775	COG2213	PTS system mannitol-specific
F131LOC_RS20775	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
F131LOC_RS20785	COG0751	glycine-tRNA ligase activity
F131LOC_RS20790	COG0752	glycyl-tRNA synthetase alpha subunit
F131LOC_RS20795	COG0730	response to heat
F131LOC_RS20800	COG2818	Glycosylase
F131LOC_RS20805	COG0456	acetyltransferase
F131LOC_RS20810	COG0840	transmembrane signaling receptor activity
F131LOC_RS20815	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F131LOC_RS20835	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F131LOC_RS20840	COG4172	Belongs to the ABC transporter superfamily
F131LOC_RS20845	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F131LOC_RS20860	COG1280	lysine exporter protein (LysE YggA)
F131LOC_RS20865	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
F131LOC_RS20875	COG1028	Short-chain dehydrogenase reductase Sdr
F131LOC_RS20880	COG1408	metallophosphoesterase
F131LOC_RS20885	COG0583	DNA-binding transcription factor activity
F131LOC_RS20890	COG2814	Major facilitator Superfamily
F131LOC_RS20895	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F131LOC_RS20900	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
F131LOC_RS20910	COG2214	Heat shock protein DnaJ domain protein
F131LOC_RS20915	COG0443	Heat shock 70 kDa protein
F131LOC_RS20930	COG3712	iron ion homeostasis
F131LOC_RS20935	COG1595	DNA-templated transcription, initiation
F131LOC_RS20940	COG1629	transport
F131LOC_RS20950	COG0742	ribosomal rna small subunit methyltransferase
F131LOC_RS20955	COG0737	Belongs to the 5'-nucleotidase family
F131LOC_RS20965	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
F131LOC_RS20970	COG0589	response to stress
F131LOC_RS20980	COG0306	phosphate transporter
F131LOC_RS20985	COG2081	HI0933 family
F131LOC_RS20990	COG2207	Transcriptional regulator
F131LOC_RS20995	COG2200	EAL domain
F131LOC_RS21010	COG2194	sulfuric ester hydrolase activity
F131LOC_RS21015	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
F131LOC_RS21020	COG0194	GDP metabolic process
F131LOC_RS21025	COG1758	RNA polymerase activity
F131LOC_RS21030	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
F131LOC_RS21035	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F131LOC_RS21040	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
F131LOC_RS21045	COG2233	PERMEase
F131LOC_RS21050	COG2982	Protein involved in outer membrane biogenesis
F131LOC_RS21055	COG0456	acetyltransferase
F131LOC_RS21060	COG1490	D-aminoacyl-tRNA deacylase activity
F131LOC_RS21065	COG1011	Hydrolase
F131LOC_RS21080	COG3852	Histidine kinase
F131LOC_RS21095	COG0635	Involved in the biosynthesis of porphyrin-containing compound
F131LOC_RS21105	COG3078	GTPase activator activity
F131LOC_RS21110	COG0218	Necessary for normal cell division and for the maintenance of normal septation
F131LOC_RS21115	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F131LOC_RS21115	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F131LOC_RS21125	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
F131LOC_RS21130	COG3084	Protein conserved in bacteria
F131LOC_RS21135	COG0746	molybdenum cofactor guanylyltransferase activity
F131LOC_RS21140	COG1763	Mo-molybdopterin cofactor biosynthetic process
F131LOC_RS21170	COG1609	Transcriptional regulator
F131LOC_RS21175	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F131LOC_RS21185	COG1172	Belongs to the binding-protein-dependent transport system permease family
F131LOC_RS21190	COG1129	ABC transporter
F131LOC_RS21195	COG1869	D-ribose catabolic process
F131LOC_RS21200	COG3111	PFAM Bacterial OB fold (BOF) protein
F131LOC_RS21210	COG0642	Histidine kinase
F131LOC_RS21215	COG3158	transport of potassium into the cell
F131LOC_RS21220	COG0714	Associated with various cellular activities
F131LOC_RS21225	COG2425	protein containing a von Willebrand factor type A (vWA) domain
F131LOC_RS21230	COG2502	aspartate--ammonia ligase
F131LOC_RS21235	COG1522	sequence-specific DNA binding
F131LOC_RS21240	COG0716	FMN binding
F131LOC_RS21245	COG0445	tRNA wobble uridine modification
F131LOC_RS21250	COG0357	Ribosomal RNA small subunit methyltransferase G
F131LOC_RS21255	COG3312	ion transport
F131LOC_RS21260	COG0356	it plays a direct role in the translocation of protons across the membrane
F131LOC_RS21270	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
F131LOC_RS21275	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
F131LOC_RS21280	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
F131LOC_RS21285	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
F131LOC_RS21290	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
F131LOC_RS21295	COG0355	proton-transporting ATP synthase activity, rotational mechanism
F131LOC_RS21305	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
F131LOC_RS21310	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
F131LOC_RS21335	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F131LOC_RS21340	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F131LOC_RS21350	COG0318	PFAM AMP-dependent synthetase and ligase
F131LOC_RS21355	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
F131LOC_RS21355	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
F131LOC_RS21360	COG1216	Glycosyl transferase, family 2
F131LOC_RS21385	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F131LOC_RS21395	COG1028	Short-chain dehydrogenase reductase Sdr
F131LOC_RS21410	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
F131LOC_RS21415	COG0573	inorganic phosphate transmembrane transporter activity
F131LOC_RS21420	COG0581	inorganic phosphate transmembrane transporter activity
F131LOC_RS21425	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
F131LOC_RS21435	COG1396	sequence-specific DNA binding
F131LOC_RS21440	COG3135	benzoate transporter
F131LOC_RS21445	COG0346	lactoylglutathione lyase activity
F131LOC_RS21455	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F131LOC_RS21460	COG0765	amino acid transport
F131LOC_RS21465	COG0765	amino acid transport
F131LOC_RS21470	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F131LOC_RS21475	COG2252	PERMEase
F131LOC_RS21480	COG2091	lysine biosynthetic process via aminoadipic acid
F131LOC_RS21485	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
F131LOC_RS21490	COG0493	'glutamate synthase
F131LOC_RS21490	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
F131LOC_RS21520	COG1733	regulation of RNA biosynthetic process
F131LOC_RS21525	COG0702	epimerase
F131LOC_RS21550	COG1396	sequence-specific DNA binding
F131LOC_RS21560	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
F131LOC_RS21565	COG0706	membrane insertase activity
F131LOC_RS21575	COG0594	ribonuclease P activity
F131LOC_RS21580	COG0230	Belongs to the bacterial ribosomal protein bL34 family