locus-tag	class	description
A7983_RS00065	COG2801	Transposase and inactivated derivatives
A7983_RS00075	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A7983_RS00100	COG2963	transposase activity
A7983_RS00110	COG3547	Transposase (IS116 IS110 IS902 family)
A7983_RS00155	COG2003	Belongs to the UPF0758 family
A7983_RS00170	COG3596	GTP binding
A7983_RS00260	COG0582	viral genome integration into host DNA
A7983_RS00280	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A7983_RS00285	COG0322	excinuclease ABC activity
A7983_RS00290	COG2197	response regulator
A7983_RS00310	COG1113	amino acid transport
A7983_RS00330	COG0582	viral genome integration into host DNA
A7983_RS00335	COG3300	MHYT domain
A7983_RS00335	COG5001	Diguanylate cyclase
A7983_RS00385	COG0582	viral genome integration into host DNA
A7983_RS00490	COG2814	Major facilitator Superfamily
A7983_RS00515	COG0300	oxidoreductase activity
A7983_RS00520	COG1733	regulation of RNA biosynthetic process
A7983_RS00525	COG2085	NADP oxidoreductase coenzyme F420-dependent
A7983_RS00530	COG0659	secondary active sulfate transmembrane transporter activity
A7983_RS00540	COG0444	Belongs to the ABC transporter superfamily
A7983_RS00550	COG0601	transmembrane transport
A7983_RS00555	COG0747	negative chemotaxis
A7983_RS00565	COG4948	Mandelate Racemase Muconate Lactonizing
A7983_RS00580	COG0765	amino acid transport
A7983_RS00585	COG0765	amino acid transport
A7983_RS00590	COG1126	abc transporter atp-binding protein
A7983_RS00605	COG2076	Multidrug Resistance protein
A7983_RS00610	COG1309	transcriptional regulator
A7983_RS00625	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
A7983_RS00635	COG1902	pentaerythritol trinitrate reductase activity
A7983_RS00640	COG0640	Transcriptional regulator
A7983_RS00645	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
A7983_RS00660	COG4807	Protein conserved in bacteria
A7983_RS00665	COG5464	transposase or invertase
A7983_RS00670	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A7983_RS00670	COG1648	precorrin-2 dehydrogenase activity
A7983_RS00675	COG0243	molybdopterin cofactor binding
A7983_RS00680	COG2146	nitrite reductase [NAD(P)H] activity
A7983_RS00680	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A7983_RS00685	COG1116	anion transmembrane transporter activity
A7983_RS00705	COG3707	response regulator
A7983_RS00720	COG2149	membrane
A7983_RS00730	COG3058	Necessary for formate dehydrogenase activity
A7983_RS00735	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A7983_RS00740	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A7983_RS00740	COG0519	Catalyzes the synthesis of GMP from XMP
A7983_RS00765	COG4771	TonB-dependent receptor
A7983_RS00775	COG0488	(ABC) transporter
A7983_RS00780	COG0384	phenazine biosynthesis protein PhzF
A7983_RS00785	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A7983_RS00800	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A7983_RS00810	COG2223	nitrite transmembrane transporter activity
A7983_RS00820	COG1263	PTS System
A7983_RS00820	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A7983_RS00825	COG0366	Alpha amylase catalytic
A7983_RS00830	COG4575	ribosome binding
A7983_RS00835	COG1007	ATP synthesis coupled electron transport
A7983_RS00840	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A7983_RS00845	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A7983_RS00850	COG0713	ATP synthesis coupled electron transport
A7983_RS00855	COG0839	Belongs to the complex I subunit 6 family
A7983_RS00860	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A7983_RS00865	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
A7983_RS00875	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
A7983_RS00880	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
A7983_RS00885	COG0649	NAD binding
A7983_RS00885	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A7983_RS00890	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A7983_RS00895	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A7983_RS00900	COG0583	DNA-binding transcription factor activity
A7983_RS00905	COG0436	Aminotransferase
A7983_RS00910	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
A7983_RS00915	COG0471	metal ion transport
A7983_RS00915	COG0490	domain, Protein
A7983_RS00920	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A7983_RS00925	COG3013	Belongs to the UPF0304 family
A7983_RS00930	COG3092	negative regulation of chromosome organization
A7983_RS00935	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A7983_RS00940	COG0857	belongs to the CobB CobQ family
A7983_RS00940	COG0280	phosphate acetyltransferase
A7983_RS00945	COG3739	integral membrane protein
A7983_RS00950	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
A7983_RS00955	COG0622	Phosphoesterase
A7983_RS00960	COG0625	glutathione transferase activity
A7983_RS00965	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A7983_RS00970	COG1090	epimerase
A7983_RS00975	COG4598	ABC transporter
A7983_RS00980	COG4160	amino acid transport
A7983_RS00985	COG4215	(ABC) transporter
A7983_RS00995	COG0163	prenyltransferase activity
A7983_RS01000	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A7983_RS01005	COG1286	toxin biosynthetic process
A7983_RS01010	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
A7983_RS01015	COG0285	dihydrofolate synthase activity
A7983_RS01020	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
A7983_RS01030	COG0586	Pfam SNARE associated Golgi protein
A7983_RS01035	COG0101	tRNA pseudouridine synthase activity
A7983_RS01040	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A7983_RS01045	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A7983_RS01050	COG0697	spore germination
A7983_RS01065	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A7983_RS01070	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A7983_RS01070	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
A7983_RS01080	COG3101	peptidyl-lysine hydroxylation
A7983_RS01085	COG0730	response to heat
A7983_RS01090	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
A7983_RS01095	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A7983_RS01100	COG2890	protein-(glutamine-N5) methyltransferase activity
A7983_RS01105	COG2840	Smr protein MutS2
A7983_RS01110	COG2062	phosphohistidine phosphatase, SixA
A7983_RS01140	COG1024	Enoyl-CoA hydratase
A7983_RS01140	COG1250	3-hydroxyacyl-CoA dehydrogenase
A7983_RS01145	COG0183	Belongs to the thiolase family
A7983_RS01150	COG3691	Protein conserved in bacteria
A7983_RS01155	COG2067	long-chain fatty acid transport protein
A7983_RS01160	COG1028	Short-chain dehydrogenase reductase Sdr
A7983_RS01165	COG0583	DNA-binding transcription factor activity
A7983_RS01185	COG0582	viral genome integration into host DNA
A7983_RS01195	COG0758	DNA mediated transformation
A7983_RS01290	COG0513	Belongs to the DEAD box helicase family
A7983_RS01300	COG1120	ATPase activity
A7983_RS01305	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A7983_RS01310	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A7983_RS01315	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A7983_RS01385	COG3266	domain, Protein
A7983_RS01395	COG0436	Aminotransferase
A7983_RS01400	COG4948	Mandelate Racemase Muconate Lactonizing
A7983_RS01410	COG3264	Mechanosensitive ion channel
A7983_RS01410	COG1511	domain protein
A7983_RS01420	COG0582	viral genome integration into host DNA
A7983_RS01440	COG0443	Heat shock 70 kDa protein
A7983_RS01480	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A7983_RS01490	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A7983_RS01495	COG1696	Membrane protein involved in D-alanine export
A7983_RS01520	COG3842	ATPase activity
A7983_RS01525	COG2076	Multidrug Resistance protein
A7983_RS01530	COG2076	Multidrug Resistance protein
A7983_RS01535	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
A7983_RS01540	COG0726	polysaccharide deacetylase
A7983_RS01545	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A7983_RS01545	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A7983_RS01550	COG0463	Glycosyl transferase, family 2
A7983_RS01555	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A7983_RS01560	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
A7983_RS01565	COG5001	Diguanylate cyclase
A7983_RS01565	COG4251	negative regulation of phosphorylation
A7983_RS01565	COG2203	Gaf domain
A7983_RS01565	COG3706	GGDEF domain
A7983_RS01570	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A7983_RS01575	COG2501	S4 domain
A7983_RS01580	COG0215	cysteine-tRNA ligase activity
A7983_RS01590	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A7983_RS01595	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A7983_RS01600	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A7983_RS01605	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A7983_RS01610	COG0814	amino acid
A7983_RS01630	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A7983_RS01635	COG0581	inorganic phosphate transmembrane transporter activity
A7983_RS01645	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
A7983_RS01665	COG1764	response to oxidative stress
A7983_RS01670	COG1846	Transcriptional regulator
A7983_RS01675	COG2239	Acts as a magnesium transporter
A7983_RS01685	COG1085	galactose-1-phosphate uridylyltransferase
A7983_RS01690	COG1609	Transcriptional regulator
A7983_RS01700	COG0277	FAD linked oxidase domain protein
A7983_RS01710	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A7983_RS01715	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A7983_RS01720	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A7983_RS01725	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A7983_RS01730	COG0477	Major facilitator Superfamily
A7983_RS01735	COG2205	protein histidine kinase activity
A7983_RS01740	COG0745	RESPONSE REGULATOR receiver
A7983_RS01745	COG0435	Glutathione S-transferase
A7983_RS01750	COG0826	peptidase U32
A7983_RS01755	COG1597	lipid kinase activity
A7983_RS01760	COG3223	Belongs to the PsiE family
A7983_RS01765	COG0351	phosphomethylpyrimidine kinase
A7983_RS01770	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
A7983_RS01775	COG0583	DNA-binding transcription factor activity
A7983_RS01780	COG3493	citrate carrier protein
A7983_RS01785	COG0179	Fumarylacetoacetate (FAA) hydrolase
A7983_RS01790	COG0066	3-isopropylmalate dehydratase activity
A7983_RS01795	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A7983_RS01800	COG1064	alcohol dehydrogenase
A7983_RS01810	COG1064	alcohol dehydrogenase
A7983_RS01855	COG3423	Transcriptional regulator
A7983_RS01870	COG0667	Aldo Keto reductase
A7983_RS01880	COG3423	Transcriptional regulator
A7983_RS01885	COG3657	addiction module killer protein
A7983_RS01895	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A7983_RS01895	COG0519	Catalyzes the synthesis of GMP from XMP
A7983_RS01900	COG0517	IMP dehydrogenase activity
A7983_RS01900	COG0516	GMP reductase activity
A7983_RS01905	COG1570	exodeoxyribonuclease VII activity
A7983_RS01920	COG1645	bacterial-type flagellum-dependent swarming motility
A7983_RS01930	COG1160	GTP binding
A7983_RS01935	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A7983_RS01940	COG2976	Protein conserved in bacteria
A7983_RS01945	COG0124	histidyl-tRNA synthetase
A7983_RS01950	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
A7983_RS01955	COG1426	Protein conserved in bacteria
A7983_RS01965	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A7983_RS01970	COG0105	UTP biosynthetic process
A7983_RS01980	COG2897	thiosulfate sulfurtransferase activity
A7983_RS01990	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A7983_RS01995	COG2975	iron-sulfur cluster assembly
A7983_RS02000	COG0633	Ferredoxin
A7983_RS02005	COG0443	Heat shock 70 kDa protein
A7983_RS02010	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
A7983_RS02015	COG0316	Belongs to the HesB IscA family
A7983_RS02020	COG0822	iron-sulfur transferase activity
A7983_RS02025	COG1104	cysteine desulfurase activity
A7983_RS02030	COG1959	2 iron, 2 sulfur cluster binding
A7983_RS02035	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
A7983_RS02040	COG0483	inositol monophosphate 1-phosphatase activity
A7983_RS02050	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A7983_RS02055	COG1120	ATPase activity
A7983_RS02065	COG0840	transmembrane signaling receptor activity
A7983_RS02075	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
A7983_RS02080	COG3683	transport system, periplasmic component
A7983_RS02085	COG2814	Major facilitator Superfamily
A7983_RS02095	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A7983_RS02100	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A7983_RS02100	COG1017	nitric oxide dioxygenase activity
A7983_RS02110	COG4677	pectinesterase activity
A7983_RS02115	COG0347	Belongs to the P(II) protein family
A7983_RS02120	COG2204	response regulator
A7983_RS02125	COG3170	Tfp pilus assembly protein FimV
A7983_RS02130	COG2205	protein histidine kinase activity
A7983_RS02135	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A7983_RS02135	COG0047	phosphoribosylformylglycinamidine synthase activity
A7983_RS02140	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
A7983_RS02150	COG0560	Phosphoserine phosphatase
A7983_RS02165	COG2199	diguanylate cyclase activity
A7983_RS02165	COG2200	EAL domain
A7983_RS02165	COG3287	FIST C domain
A7983_RS02190	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A7983_RS02205	COG2200	EAL domain
A7983_RS02210	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A7983_RS02215	COG0736	holo-[acyl-carrier-protein] synthase activity
A7983_RS02220	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
A7983_RS02225	COG1381	Involved in DNA repair and RecF pathway recombination
A7983_RS02230	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A7983_RS02235	COG0571	ribonuclease III activity
A7983_RS02240	COG0681	Belongs to the peptidase S26 family
A7983_RS02245	COG0481	GTPase activity
A7983_RS02250	COG3086	response to oxidative stress
A7983_RS02255	COG3026	antisigma factor binding
A7983_RS02270	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
A7983_RS02275	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
A7983_RS02280	COG0513	Belongs to the DEAD box helicase family
A7983_RS02285	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
A7983_RS02290	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
A7983_RS02305	COG2819	hydrolase of the alpha beta superfamily
A7983_RS02310	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A7983_RS02350	COG1902	pentaerythritol trinitrate reductase activity
A7983_RS02355	COG0667	Aldo Keto reductase
A7983_RS02360	COG1309	transcriptional regulator
A7983_RS02370	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
A7983_RS02375	COG4208	sulfate ABC transporter
A7983_RS02385	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
A7983_RS02390	COG3835	regulator
A7983_RS02395	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A7983_RS02400	COG0232	Belongs to the dGTPase family. Type 2 subfamily
A7983_RS02405	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A7983_RS02410	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A7983_RS02420	COG0316	Belongs to the HesB IscA family
A7983_RS02425	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A7983_RS02430	COG0625	glutathione transferase activity
A7983_RS02435	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A7983_RS02445	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A7983_RS02450	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A7983_RS02455	COG1120	ATPase activity
A7983_RS02460	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A7983_RS02465	COG1643	Atp-dependent helicase
A7983_RS02470	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
A7983_RS02475	COG1489	DNA binding
A7983_RS02485	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A7983_RS02495	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A7983_RS02500	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
A7983_RS02505	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
A7983_RS02510	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
A7983_RS02515	COG0842	Transport permease protein
A7983_RS02520	COG1131	(ABC) transporter
A7983_RS02525	COG0288	reversible hydration of carbon dioxide
A7983_RS02540	COG3842	ATPase activity
A7983_RS02555	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A7983_RS02560	COG1780	Probably involved in ribonucleotide reductase function
A7983_RS02570	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A7983_RS02585	COG0328	RNA-DNA hybrid ribonuclease activity
A7983_RS02590	COG2226	methyltransferase
A7983_RS02595	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A7983_RS02600	COG0741	lytic transglycosylase activity
A7983_RS02600	COG1388	LysM domain
A7983_RS02605	COG3021	interspecies interaction between organisms
A7983_RS02635	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A7983_RS02640	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A7983_RS02645	COG2011	ABC-type metal ion transport system permease component
A7983_RS02650	COG1464	Belongs to the NlpA lipoprotein family
A7983_RS02660	COG1720	tRNA m6t6A37 methyltransferase activity
A7983_RS02665	COG0442	prolyl-tRNA aminoacylation
A7983_RS02675	COG1388	LysM domain
A7983_RS02675	COG4942	peptidase
A7983_RS02680	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A7983_RS02685	COG0585	pseudouridine synthase activity
A7983_RS02690	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
A7983_RS02695	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
A7983_RS02700	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
A7983_RS02710	COG0765	amino acid transport
A7983_RS02715	COG1126	abc transporter atp-binding protein
A7983_RS02725	COG0529	Catalyzes the synthesis of activated sulfate
A7983_RS02730	COG2895	sulfate adenylyltransferase (ATP) activity
A7983_RS02735	COG0175	sulfate reduction
A7983_RS02740	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A7983_RS02740	COG1648	precorrin-2 dehydrogenase activity
A7983_RS02750	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A7983_RS02755	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
A7983_RS02770	COG0720	synthase
A7983_RS02775	COG0602	queuosine metabolic process
A7983_RS02780	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A7983_RS02810	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
A7983_RS02820	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A7983_RS02825	COG4774	siderophore transport
A7983_RS02830	COG0148	phosphopyruvate hydratase activity
A7983_RS02835	COG0504	CTP synthase activity
A7983_RS02840	COG3956	TIGRFAM MazG family protein
A7983_RS02845	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A7983_RS02850	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A7983_RS02860	COG1929	Belongs to the glycerate kinase type-1 family
A7983_RS02865	COG2084	Dehydrogenase
A7983_RS02875	COG4948	Mandelate Racemase Muconate Lactonizing
A7983_RS02880	COG4948	Mandelate Racemase Muconate Lactonizing
A7983_RS02885	COG2271	Major facilitator Superfamily
A7983_RS02890	COG2721	sulfolactate sulfo-lyase activity
A7983_RS02895	COG0840	transmembrane signaling receptor activity
A7983_RS02905	COG3530	Putative quorum-sensing-regulated virulence factor
A7983_RS02910	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A7983_RS02915	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A7983_RS02915	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
A7983_RS02920	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
A7983_RS02925	COG3025	triphosphatase activity
A7983_RS02930	COG4991	sh3 domain protein
A7983_RS02935	COG0617	tRNA 3'-terminal CCA addition
A7983_RS02940	COG1968	undecaprenyl-diphosphatase activity
A7983_RS02945	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A7983_RS02950	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
A7983_RS02955	COG0840	transmembrane signaling receptor activity
A7983_RS02960	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
A7983_RS02965	COG2105	PFAM AIG2 family protein
A7983_RS02970	COG2911	Protein conserved in bacteria
A7983_RS02975	COG0729	surface antigen
A7983_RS02980	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A7983_RS02985	COG1253	flavin adenine dinucleotide binding
A7983_RS02995	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
A7983_RS03000	COG1218	3'(2'),5'-bisphosphate nucleotidase
A7983_RS03005	COG0737	Belongs to the 5'-nucleotidase family
A7983_RS03020	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
A7983_RS03025	COG0545	Peptidyl-prolyl cis-trans isomerase
A7983_RS03030	COG3061	Opacity-associated protein A
A7983_RS03040	COG0359	binds to the 23S rRNA
A7983_RS03045	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A7983_RS03050	COG0360	Binds together with S18 to 16S ribosomal RNA
A7983_RS03055	COG1073	alpha beta
A7983_RS03065	COG1690	Belongs to the RtcB family
A7983_RS03070	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A7983_RS03090	COG3766	membrane
A7983_RS03100	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A7983_RS03105	COG0557	exoribonuclease II activity
A7983_RS03110	COG1959	2 iron, 2 sulfur cluster binding
A7983_RS03125	COG2805	Type II/IV secretion system protein
A7983_RS03130	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A7983_RS03135	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A7983_RS03140	COG0762	integral membrane protein
A7983_RS03145	COG1872	DUF167
A7983_RS03150	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A7983_RS03155	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A7983_RS03165	COG2153	protein acetylation
A7983_RS03170	COG0477	Major facilitator Superfamily
A7983_RS03175	COG0204	Acyl-transferase
A7983_RS03175	COG0318	PFAM AMP-dependent synthetase and ligase
A7983_RS03180	COG0840	transmembrane signaling receptor activity
A7983_RS03190	COG1609	Transcriptional regulator
A7983_RS03195	COG3835	regulator
A7983_RS03210	COG2610	gluconate transmembrane transporter activity
A7983_RS03265	COG0583	DNA-binding transcription factor activity
A7983_RS03270	COG0583	DNA-binding transcription factor activity
A7983_RS03280	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
A7983_RS03295	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
A7983_RS03300	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A7983_RS03310	COG2124	cytochrome p450
A7983_RS03325	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A7983_RS03335	COG1522	sequence-specific DNA binding
A7983_RS03345	COG1448	Aminotransferase
A7983_RS03350	COG1451	nucleotide metabolic process
A7983_RS03395	COG1203	CRISPR-associated helicase, Cas3
A7983_RS03400	COG1518	maintenance of DNA repeat elements
A7983_RS03405	COG0432	Pfam Uncharacterised protein family UPF0047
A7983_RS03430	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A7983_RS03445	COG1121	(ABC) transporter
A7983_RS03450	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A7983_RS03455	COG0803	Belongs to the bacterial solute-binding protein 9 family
A7983_RS03470	COG4245	von Willebrand factor, type A
A7983_RS03485	COG4245	von Willebrand factor, type A
A7983_RS03500	COG1358	cellular component organization or biogenesis
A7983_RS03555	COG1349	DNA-binding transcription factor activity
A7983_RS03560	COG1414	Transcriptional regulator
A7983_RS03565	COG2610	gluconate transmembrane transporter activity
A7983_RS03570	COG0129	dihydroxy-acid dehydratase activity
A7983_RS03575	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A7983_RS03580	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
A7983_RS03585	COG3395	kinase activity
A7983_RS03590	COG1454	alcohol dehydrogenase
A7983_RS03595	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A7983_RS03610	COG2731	YhcH YjgK YiaL family protein
A7983_RS03615	COG1028	Short-chain dehydrogenase reductase Sdr
A7983_RS03620	COG1882	Formate acetyltransferase
A7983_RS03625	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A7983_RS03640	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A7983_RS03645	COG1940	carbohydrate kinase activity
A7983_RS03650	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A7983_RS03660	COG1172	Belongs to the binding-protein-dependent transport system permease family
A7983_RS03665	COG1129	ABC transporter
A7983_RS03675	COG1349	DNA-binding transcription factor activity
A7983_RS03680	COG3112	Uncharacterised protein family (UPF0231)
A7983_RS03685	COG4592	Periplasmic binding protein
A7983_RS03690	COG0477	Major facilitator Superfamily
A7983_RS03695	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A7983_RS03700	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A7983_RS03705	COG1120	ATPase activity
A7983_RS03720	COG2382	esterase
A7983_RS03725	COG4774	siderophore transport
A7983_RS03730	COG3433	isochorismatase activity
A7983_RS03730	COG1535	isochorismatase
A7983_RS03750	COG0640	Transcriptional regulator
A7983_RS03755	COG4771	TonB-dependent receptor
A7983_RS03760	COG2207	Transcriptional regulator
A7983_RS03765	COG2079	MmgE PrpD family protein
A7983_RS03775	COG1073	alpha beta
A7983_RS03780	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A7983_RS03785	COG0508	dehydrogenase complex catalyzes the overall conversion of
A7983_RS03790	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
A7983_RS03800	COG1113	amino acid transport
A7983_RS03805	COG2211	Major facilitator Superfamily
A7983_RS03810	COG3940	Belongs to the glycosyl hydrolase 43 family
A7983_RS03815	COG3725	Membrane protein required for beta-lactamase induction
A7983_RS03820	COG3023	N-Acetylmuramoyl-L-alanine amidase
A7983_RS03825	COG3248	Nucleoside-binding outer membrane protein
A7983_RS03830	COG0157	Belongs to the NadC ModD family
A7983_RS03835	COG4969	Belongs to the N-Me-Phe pilin family
A7983_RS03845	COG1459	type II secretion system
A7983_RS03850	COG0516	GMP reductase activity
A7983_RS03855	COG0237	dephospho-CoA kinase activity
A7983_RS03860	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
A7983_RS03865	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
A7983_RS03870	COG0494	nUDIX hydrolase
A7983_RS03875	COG0653	protein targeting
A7983_RS03890	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
A7983_RS03895	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A7983_RS03900	COG0849	cell division
A7983_RS03905	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
A7983_RS03910	COG1181	Belongs to the D-alanine--D-alanine ligase family
A7983_RS03915	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A7983_RS03920	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A7983_RS03925	COG0772	Belongs to the SEDS family
A7983_RS03930	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A7983_RS03935	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A7983_RS03940	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A7983_RS03945	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A7983_RS03950	COG0768	penicillin binding
A7983_RS03955	COG3116	cell division
A7983_RS03960	COG0275	rRNA processing
A7983_RS03965	COG2001	Belongs to the MraZ family
A7983_RS03985	COG0028	Belongs to the TPP enzyme family
A7983_RS03990	COG1022	Amp-dependent synthetase and ligase
A7983_RS03995	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A7983_RS04000	COG0473	3-isopropylmalate dehydrogenase activity
A7983_RS04005	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A7983_RS04010	COG0066	3-isopropylmalate dehydratase activity
A7983_RS04030	COG0840	transmembrane signaling receptor activity
A7983_RS04045	COG4533	DNA binding
A7983_RS04060	COG4143	(ABC) transporter
A7983_RS04065	COG1178	ABC-type Fe3 transport system permease component
A7983_RS04070	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
A7983_RS04075	COG3507	Belongs to the glycosyl hydrolase 43 family
A7983_RS04080	COG0028	Belongs to the TPP enzyme family
A7983_RS04085	COG0440	acetolactate synthase activity
A7983_RS04090	COG0586	Pfam SNARE associated Golgi protein
A7983_RS04110	COG2801	Transposase and inactivated derivatives
A7983_RS04120	COG3209	COG3209 Rhs family protein
A7983_RS04120	COG4104	PAAR repeat-containing protein
A7983_RS04135	COG3209	COG3209 Rhs family protein
A7983_RS04175	COG0417	DNA replication proofreading
A7983_RS04180	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A7983_RS04210	COG0564	pseudouridine synthase activity
A7983_RS04215	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
A7983_RS04220	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
A7983_RS04225	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A7983_RS04230	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
A7983_RS04235	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A7983_RS04240	COG2967	ApaG domain
A7983_RS04245	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A7983_RS04255	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
A7983_RS04260	COG3610	response to peptide
A7983_RS04265	COG2966	Psort location CytoplasmicMembrane, score
A7983_RS04275	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A7983_RS04280	COG0505	Belongs to the CarA family
A7983_RS04285	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A7983_RS04290	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
A7983_RS04295	COG1047	Peptidyl-prolyl cis-trans
A7983_RS04305	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A7983_RS04310	COG0196	riboflavin kinase activity
A7983_RS04315	COG0268	Binds directly to 16S ribosomal RNA
A7983_RS04320	COG0583	DNA-binding transcription factor activity
A7983_RS04325	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A7983_RS04330	COG0484	heat shock protein binding
A7983_RS04340	COG1584	GPR1 FUN34 yaaH family protein
A7983_RS04350	COG0521	Mo-molybdopterin cofactor biosynthetic process
A7983_RS04360	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A7983_RS04365	COG3022	response to hydroperoxide
A7983_RS04375	COG0083	homoserine kinase activity
A7983_RS04385	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
A7983_RS04390	COG0745	RESPONSE REGULATOR receiver
A7983_RS04395	COG3045	CreA protein
A7983_RS04400	COG3708	Transcriptional regulator
A7983_RS04400	COG2207	Transcriptional regulator
A7983_RS04410	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
A7983_RS04415	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
A7983_RS04430	COG0840	transmembrane signaling receptor activity
A7983_RS04435	COG0604	alcohol dehydrogenase
A7983_RS04440	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A7983_RS04445	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
A7983_RS04450	COG0583	DNA-binding transcription factor activity
A7983_RS04475	COG1414	Transcriptional regulator
A7983_RS04480	COG1129	ABC transporter
A7983_RS04485	COG1172	Belongs to the binding-protein-dependent transport system permease family
A7983_RS04505	COG2731	YhcH YjgK YiaL family protein
A7983_RS04515	COG1070	Carbohydrate kinase
A7983_RS04520	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
A7983_RS04525	COG3623	hexulose-6-phosphate isomerase
A7983_RS04530	COG0235	Class ii aldolase
A7983_RS04535	COG0668	transmembrane transport
A7983_RS04540	COG0191	fructose-bisphosphate aldolase activity
A7983_RS04545	COG0126	phosphoglycerate kinase activity
A7983_RS04550	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A7983_RS04555	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A7983_RS04560	COG0501	Belongs to the peptidase M48B family
A7983_RS04570	COG1166	arginine decarboxylase activity
A7983_RS04575	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A7983_RS04580	COG3091	SprT-like family
A7983_RS04585	COG2356	endonuclease I
A7983_RS04590	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A7983_RS04595	COG0189	ligase activity
A7983_RS04600	COG1678	Uncharacterized ACR, COG1678
A7983_RS04605	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A7983_RS04610	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
A7983_RS04620	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A7983_RS04625	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
A7983_RS04630	COG0330	HflC and HflK could
A7983_RS04635	COG0330	HflC and HflK could
A7983_RS04645	COG1923	regulation of RNA biosynthetic process
A7983_RS04650	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A7983_RS04655	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
A7983_RS04660	COG0860	N-Acetylmuramoyl-L-alanine amidase
A7983_RS04665	COG0802	atpase or kinase
A7983_RS04675	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A7983_RS04690	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
A7983_RS04710	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A7983_RS04725	COG1704	LemA family
A7983_RS04765	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
A7983_RS04770	COG1162	GTPase activity
A7983_RS04775	COG0688	phosphatidylethanolamine metabolic process
A7983_RS04780	COG3264	Mechanosensitive ion channel
A7983_RS04780	COG1511	domain protein
A7983_RS04785	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
A7983_RS04790	COG1053	succinate dehydrogenase
A7983_RS04795	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A7983_RS04800	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
A7983_RS04805	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
A7983_RS04810	COG3040	lipid binding
A7983_RS04825	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A7983_RS04830	COG1509	lysine 2,3-aminomutase activity
A7983_RS04840	COG0166	Belongs to the GPI family
A7983_RS04845	COG0527	aspartate kinase activity
A7983_RS04855	COG0471	metal ion transport
A7983_RS04860	COG0646	methionine synthase
A7983_RS04860	COG1410	methionine synthase
A7983_RS04865	COG1414	Transcriptional regulator
A7983_RS04880	COG4589	Belongs to the CDS family
A7983_RS04885	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
A7983_RS04895	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
A7983_RS04900	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
A7983_RS04935	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
A7983_RS04945	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A7983_RS04950	COG0009	L-threonylcarbamoyladenylate synthase
A7983_RS04955	COG0551	DNA topoisomerase type I activity
A7983_RS04960	COG2922	Belongs to the Smg family
A7983_RS04965	COG0758	DNA mediated transformation
A7983_RS04970	COG0242	peptide deformylase activity
A7983_RS04975	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A7983_RS04980	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A7983_RS04980	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A7983_RS04985	COG0569	domain protein
A7983_RS04990	COG1970	mechanosensitive ion channel activity
A7983_RS04995	COG3036	rescue of stalled ribosome
A7983_RS05000	COG0203	ribosomal protein L17
A7983_RS05005	COG0202	RNA polymerase activity
A7983_RS05010	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A7983_RS05020	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A7983_RS05025	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A7983_RS05030	COG0201	protein transport
A7983_RS05035	COG0200	Binds to the 23S rRNA
A7983_RS05040	COG1841	ribosomal large subunit assembly
A7983_RS05045	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A7983_RS05050	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A7983_RS05055	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A7983_RS05060	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A7983_RS05065	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A7983_RS05070	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A7983_RS05075	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A7983_RS05085	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A7983_RS05090	COG0255	Belongs to the universal ribosomal protein uL29 family
A7983_RS05095	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A7983_RS05100	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A7983_RS05105	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A7983_RS05110	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A7983_RS05115	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A7983_RS05125	COG0088	Forms part of the polypeptide exit tunnel
A7983_RS05130	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A7983_RS05135	COG0051	transcription antitermination factor activity, RNA binding
A7983_RS05140	COG2193	ferroxidase activity
A7983_RS05150	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A7983_RS05155	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A7983_RS05160	COG0049	tRNA binding
A7983_RS05165	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A7983_RS05170	COG2168	tRNA wobble position uridine thiolation
A7983_RS05175	COG2923	Belongs to the DsrF TusC family
A7983_RS05180	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
A7983_RS05185	COG2964	Protein conserved in bacteria
A7983_RS05190	COG2194	sulfuric ester hydrolase activity
A7983_RS05195	COG0745	RESPONSE REGULATOR receiver
A7983_RS05200	COG0642	Histidine kinase
A7983_RS05205	COG0545	Peptidyl-prolyl cis-trans isomerase
A7983_RS05210	COG2900	Belongs to the SlyX family
A7983_RS05215	COG1733	regulation of RNA biosynthetic process
A7983_RS05230	COG1047	Peptidyl-prolyl cis-trans
A7983_RS05235	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
A7983_RS05240	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A7983_RS05240	COG0475	glutathione-regulated potassium exporter activity
A7983_RS05245	COG2249	NAD(P)H dehydrogenase (quinone) activity
A7983_RS05250	COG0488	(ABC) transporter
A7983_RS05260	COG0429	hydrolase of the alpha beta-hydrolase fold
A7983_RS05265	COG3089	Belongs to the UPF0270 family
A7983_RS05270	COG3954	Phosphoribulokinase
A7983_RS05275	COG1765	OsmC-like protein
A7983_RS05280	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A7983_RS05315	COG3866	Pectate lyase
A7983_RS05330	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A7983_RS05335	COG4608	Belongs to the ABC transporter superfamily
A7983_RS05340	COG0444	Belongs to the ABC transporter superfamily
A7983_RS05345	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A7983_RS05350	COG0601	transmembrane transport
A7983_RS05355	COG0747	negative chemotaxis
A7983_RS05360	COG4948	Mandelate Racemase Muconate Lactonizing
A7983_RS05365	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A7983_RS05375	COG1648	precorrin-2 dehydrogenase activity
A7983_RS05375	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A7983_RS05400	COG1473	amidohydrolase
A7983_RS05410	COG0546	phosphoglycolate phosphatase activity
A7983_RS05415	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A7983_RS05430	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A7983_RS05435	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A7983_RS05440	COG4796	Type ii and iii secretion system protein
A7983_RS05465	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
A7983_RS05470	COG0494	nUDIX hydrolase
A7983_RS05480	COG1011	Hydrolase
A7983_RS05485	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
A7983_RS05490	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
A7983_RS05495	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
A7983_RS05515	COG2814	Major facilitator Superfamily
A7983_RS05520	COG4774	siderophore transport
A7983_RS05535	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A7983_RS05540	COG3550	peptidyl-serine autophosphorylation
A7983_RS05555	COG0840	transmembrane signaling receptor activity
A7983_RS05565	COG2972	Histidine kinase
A7983_RS05570	COG2207	Transcriptional regulator
A7983_RS05570	COG1917	Cupin 2, conserved barrel domain protein
A7983_RS05575	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A7983_RS05580	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
A7983_RS05595	COG1882	Formate acetyltransferase
A7983_RS05600	COG0693	protein deglycase activity
A7983_RS05610	COG1012	belongs to the aldehyde dehydrogenase family
A7983_RS05625	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A7983_RS05635	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
A7983_RS05645	COG4869	propanediol catabolic process
A7983_RS05655	COG2183	response to ionizing radiation
A7983_RS05660	COG1414	Transcriptional regulator
A7983_RS05685	COG1262	PFAM Formylglycine-generating sulfatase enzyme
A7983_RS05685	COG0515	serine threonine protein kinase
A7983_RS05695	COG1136	(ABC) transporter
A7983_RS05705	COG1785	Belongs to the alkaline phosphatase family
A7983_RS05715	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A7983_RS05720	COG2267	carboxylic ester hydrolase activity
A7983_RS05725	COG1040	competence protein
A7983_RS05730	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
A7983_RS05730	COG0316	Belongs to the HesB IscA family
A7983_RS05735	COG1640	4-alpha-glucanotransferase
A7983_RS05740	COG0058	SHG alpha-glucan phosphorylase activity
A7983_RS05745	COG1349	DNA-binding transcription factor activity
A7983_RS05750	COG0705	Rhomboid family
A7983_RS05755	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A7983_RS05760	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A7983_RS05765	COG2731	YhcH YjgK YiaL family protein
A7983_RS05770	COG2271	Major facilitator Superfamily
A7983_RS05775	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A7983_RS05780	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A7983_RS05800	COG0058	SHG alpha-glucan phosphorylase activity
A7983_RS05805	COG0297	glycogen (starch) synthase activity
A7983_RS05810	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
A7983_RS05815	COG1523	belongs to the glycosyl hydrolase 13 family
A7983_RS05820	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
A7983_RS05825	COG3275	phosphorelay sensor kinase activity
A7983_RS05835	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A7983_RS05840	COG2095	MarC family integral membrane protein
A7983_RS05850	COG1741	Belongs to the pirin family
A7983_RS05855	COG0247	lactate metabolic process
A7983_RS05860	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
A7983_RS05865	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A7983_RS05870	COG2271	Major facilitator Superfamily
A7983_RS05875	COG0561	phosphatase activity
A7983_RS05880	COG2267	carboxylic ester hydrolase activity
A7983_RS05885	COG1280	lysine exporter protein (LysE YggA)
A7983_RS05890	COG1280	lysine exporter protein (LysE YggA)
A7983_RS05895	COG0514	ATP-dependent DNA helicase (RecQ)
A7983_RS05905	COG2050	protein possibly involved in aromatic compounds catabolism
A7983_RS05915	COG3180	Ammonia monooxygenase
A7983_RS05920	COG0598	Magnesium transport protein CorA
A7983_RS05925	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
A7983_RS05930	COG0210	DNA helicase
A7983_RS05935	COG1011	Hydrolase
A7983_RS05950	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A7983_RS05960	COG1965	Belongs to the frataxin family
A7983_RS05965	COG2814	Major facilitator Superfamily
A7983_RS05975	COG0181	hydroxymethylbilane synthase activity
A7983_RS05980	COG1587	Uroporphyrinogen-III synthase
A7983_RS05985	COG2959	enzyme of heme biosynthesis
A7983_RS05990	COG3071	HemY protein
A7983_RS05995	COG1802	Transcriptional regulator
A7983_RS06015	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7983_RS06020	COG4597	amino acid ABC transporter
A7983_RS06025	COG0765	amino acid transport
A7983_RS06030	COG1126	abc transporter atp-binding protein
A7983_RS06035	COG1473	amidohydrolase
A7983_RS06040	COG1126	abc transporter atp-binding protein
A7983_RS06045	COG0765	amino acid transport
A7983_RS06050	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7983_RS06055	COG0456	acetyltransferase
A7983_RS06060	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A7983_RS06070	COG0371	Dehydrogenase
A7983_RS06075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7983_RS06105	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
A7983_RS06115	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A7983_RS06120	COG2244	polysaccharide biosynthetic process
A7983_RS06125	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A7983_RS06130	COG0456	acetyltransferase
A7983_RS06135	COG1088	dTDP-glucose 4,6-dehydratase activity
A7983_RS06140	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
A7983_RS06145	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
A7983_RS06150	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
A7983_RS06155	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A7983_RS06160	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A7983_RS06165	COG3118	belongs to the thioredoxin family
A7983_RS06170	COG0513	Belongs to the DEAD box helicase family
A7983_RS06175	COG0248	Ppx GppA phosphatase
A7983_RS06185	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A7983_RS06200	COG0583	DNA-binding transcription factor activity
A7983_RS06210	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A7983_RS06215	COG0583	DNA-binding transcription factor activity
A7983_RS06235	COG0129	dihydroxy-acid dehydratase activity
A7983_RS06245	COG3978	acetolactate synthase activity
A7983_RS06260	COG3085	chromosome segregation
A7983_RS06265	COG0583	DNA-binding transcription factor activity
A7983_RS06270	COG1172	Belongs to the binding-protein-dependent transport system permease family
A7983_RS06275	COG1172	Belongs to the binding-protein-dependent transport system permease family
A7983_RS06280	COG1129	ABC transporter
A7983_RS06285	COG1879	ABC-type sugar transport system periplasmic component
A7983_RS06325	COG0138	bifunctional purine biosynthesis protein purh
A7983_RS06330	COG0151	Belongs to the GarS family
A7983_RS06350	COG1515	deoxyribonuclease V activity
A7983_RS06355	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
A7983_RS06360	COG2816	NAD+ diphosphatase activity
A7983_RS06365	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
A7983_RS06370	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
A7983_RS06375	COG0352	thiamine-phosphate diphosphorylase activity
A7983_RS06380	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A7983_RS06385	COG2104	thiamine diphosphate biosynthetic process
A7983_RS06390	COG2022	thiamine diphosphate biosynthetic process
A7983_RS06400	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A7983_RS06405	COG0477	Major facilitator Superfamily
A7983_RS06410	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A7983_RS06415	COG0085	RNA polymerase activity
A7983_RS06420	COG0222	ribosome binding
A7983_RS06425	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A7983_RS06430	COG0081	regulation of translation
A7983_RS06435	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A7983_RS06440	COG0250	Participates in transcription elongation, termination and antitermination
A7983_RS06450	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A7983_RS06475	COG1072	(Pantothenic acid kinase))
A7983_RS06480	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
A7983_RS06480	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
A7983_RS06485	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A7983_RS06510	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A7983_RS06515	COG4206	TonB-dependent receptor
A7983_RS06520	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A7983_RS06535	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A7983_RS06550	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
A7983_RS06555	COG1609	Transcriptional regulator
A7983_RS06560	COG0395	ABC-type sugar transport system, permease component
A7983_RS06575	COG3842	ATPase activity
A7983_RS06580	COG0460	homoserine dehydrogenase
A7983_RS06580	COG0527	aspartate kinase activity
A7983_RS06585	COG0626	cystathionine gamma-synthase activity
A7983_RS06590	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
A7983_RS06595	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
A7983_RS06605	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A7983_RS06615	COG1598	PFAM Uncharacterised protein family UPF0150
A7983_RS06620	COG0254	rRNA binding
A7983_RS06625	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A7983_RS06630	COG1609	Transcriptional regulator
A7983_RS06635	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A7983_RS06640	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
A7983_RS06645	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
A7983_RS06650	COG1575	Belongs to the MenA family. Type 1 subfamily
A7983_RS06655	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A7983_RS06660	COG3074	FtsZ-dependent cytokinesis
A7983_RS06665	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A7983_RS06675	COG1494	fructose-1,6-bisphosphatase
A7983_RS06685	COG3152	Membrane
A7983_RS06700	COG2957	Belongs to the agmatine deiminase family
A7983_RS06705	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A7983_RS06740	COG3209	COG3209 Rhs family protein
A7983_RS06740	COG4104	PAAR repeat-containing protein
A7983_RS06755	COG4104	PAAR repeat-containing protein
A7983_RS06755	COG3209	COG3209 Rhs family protein
A7983_RS06770	COG3209	COG3209 Rhs family protein
A7983_RS06790	COG3501	Rhs element vgr protein
A7983_RS06795	COG0205	6-phosphofructokinase activity
A7983_RS06800	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A7983_RS06805	COG2814	Major facilitator Superfamily
A7983_RS06815	COG3552	Protein containing von Willebrand factor type A (VWA) domain
A7983_RS06820	COG2425	protein containing a von Willebrand factor type A (vWA) domain
A7983_RS06825	COG0714	Associated with various cellular activities
A7983_RS06830	COG3831	ATPase activity
A7983_RS06835	COG3678	ATP-independent chaperone mediated protein folding
A7983_RS06840	COG0745	RESPONSE REGULATOR receiver
A7983_RS06845	COG2205	protein histidine kinase activity
A7983_RS06860	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
A7983_RS06880	COG3842	ATPase activity
A7983_RS06885	COG0395	ABC-type sugar transport system, permease component
A7983_RS06890	COG1175	transmembrane transport
A7983_RS06895	COG1653	transport
A7983_RS06905	COG0840	transmembrane signaling receptor activity
A7983_RS06910	COG0840	transmembrane signaling receptor activity
A7983_RS06915	COG0840	transmembrane signaling receptor activity
A7983_RS06920	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A7983_RS06925	COG0410	ABC transporter
A7983_RS06930	COG0411	ABC transporter
A7983_RS06935	COG4177	L-phenylalanine transmembrane transporter activity
A7983_RS06940	COG0559	Belongs to the binding-protein-dependent transport system permease family
A7983_RS06945	COG0683	leucine binding
A7983_RS06960	COG2177	Part of the ABC transporter FtsEX involved in
A7983_RS06965	COG2884	Cell division ATP-binding protein ftsE
A7983_RS06970	COG0552	protein localization to endoplasmic reticulum
A7983_RS06975	COG0742	ribosomal rna small subunit methyltransferase
A7983_RS06980	COG3776	membrane
A7983_RS06990	COG3714	YhhN family
A7983_RS07000	COG0425	Belongs to the sulfur carrier protein TusA family
A7983_RS07005	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
A7983_RS07015	COG0477	Major facilitator Superfamily
A7983_RS07020	COG1295	ribonuclease BN
A7983_RS07025	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A7983_RS07030	COG0612	Peptidase, M16
A7983_RS07035	COG1301	dicarboxylic acid transport
A7983_RS07040	COG2200	EAL domain
A7983_RS07040	COG2199	diguanylate cyclase activity
A7983_RS07045	COG2194	sulfuric ester hydrolase activity
A7983_RS07070	COG1215	transferase activity, transferring glycosyl groups
A7983_RS07075	COG1215	transferase activity, transferring glycosyl groups
A7983_RS07080	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
A7983_RS07085	COG0457	Tetratricopeptide repeat
A7983_RS07085	COG3118	belongs to the thioredoxin family
A7983_RS07105	COG1802	Transcriptional regulator
A7983_RS07110	COG1063	alcohol dehydrogenase
A7983_RS07125	COG3977	Valine--pyruvate aminotransferase
A7983_RS07170	COG4608	Belongs to the ABC transporter superfamily
A7983_RS07175	COG0444	Belongs to the ABC transporter superfamily
A7983_RS07180	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A7983_RS07185	COG0601	transmembrane transport
A7983_RS07190	COG0747	negative chemotaxis
A7983_RS07200	COG3493	citrate carrier protein
A7983_RS07210	COG4565	transcriptional regulatory protein
A7983_RS07215	COG3290	protein histidine kinase activity
A7983_RS07220	COG0471	metal ion transport
A7983_RS07225	COG2985	domain, Protein
A7983_RS07225	COG0569	domain protein
A7983_RS07235	COG0071	Belongs to the small heat shock protein (HSP20) family
A7983_RS07240	COG0071	Belongs to the small heat shock protein (HSP20) family
A7983_RS07245	COG5645	(Lipo)protein
A7983_RS07250	COG0823	Involved in the tonB-independent uptake of proteins
A7983_RS07260	COG2723	6-phospho-beta-galactosidase activity
A7983_RS07265	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A7983_RS07265	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A7983_RS07270	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A7983_RS07275	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A7983_RS07280	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A7983_RS07285	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A7983_RS07290	COG1116	anion transmembrane transporter activity
A7983_RS07300	COG2271	Major facilitator Superfamily
A7983_RS07305	COG4948	Mandelate Racemase Muconate Lactonizing
A7983_RS07310	COG0800	Aldolase
A7983_RS07315	COG3734	2-keto-3-deoxy-galactonokinase
A7983_RS07320	COG2186	Transcriptional regulator
A7983_RS07325	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
A7983_RS07340	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A7983_RS07345	COG0601	transmembrane transport
A7983_RS07360	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A7983_RS07365	COG0747	negative chemotaxis
A7983_RS07380	COG0561	phosphatase activity
A7983_RS07385	COG2723	6-phospho-beta-galactosidase activity
A7983_RS07390	COG1447	Phosphotransferase system cellobiose-specific component IIA
A7983_RS07395	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A7983_RS07405	COG1609	Transcriptional regulator
A7983_RS07410	COG0840	transmembrane signaling receptor activity
A7983_RS07420	COG0187	DNA topoisomerase II activity
A7983_RS07425	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A7983_RS07430	COG0592	DNA-directed DNA polymerase activity
A7983_RS07435	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A7983_RS07440	COG0230	Belongs to the bacterial ribosomal protein bL34 family
A7983_RS07450	COG0706	membrane insertase activity
A7983_RS07455	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A7983_RS07465	COG0702	epimerase
A7983_RS07470	COG1733	regulation of RNA biosynthetic process
A7983_RS07480	COG1215	transferase activity, transferring glycosyl groups
A7983_RS07485	COG1649	PFAM Uncharacterised BCR, COG1649
A7983_RS07485	COG0726	polysaccharide deacetylase
A7983_RS07490	COG0457	Tetratricopeptide repeat
A7983_RS07500	COG2199	diguanylate cyclase activity
A7983_RS07525	COG0493	'glutamate synthase
A7983_RS07525	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
A7983_RS07530	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
A7983_RS07535	COG2091	lysine biosynthetic process via aminoadipic acid
A7983_RS07540	COG2252	PERMEase
A7983_RS07545	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A7983_RS07550	COG0765	amino acid transport
A7983_RS07555	COG0765	amino acid transport
A7983_RS07560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7983_RS07565	COG3135	benzoate transporter
A7983_RS07570	COG1396	sequence-specific DNA binding
A7983_RS07580	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A7983_RS07585	COG0581	inorganic phosphate transmembrane transporter activity
A7983_RS07590	COG0573	inorganic phosphate transmembrane transporter activity
A7983_RS07595	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A7983_RS07615	COG1028	Short-chain dehydrogenase reductase Sdr
A7983_RS07625	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A7983_RS07650	COG1216	Glycosyl transferase, family 2
A7983_RS07655	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A7983_RS07660	COG0318	PFAM AMP-dependent synthetase and ligase
A7983_RS07670	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A7983_RS07675	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A7983_RS07700	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A7983_RS07705	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A7983_RS07715	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A7983_RS07720	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A7983_RS07725	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A7983_RS07730	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A7983_RS07735	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A7983_RS07740	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A7983_RS07750	COG0356	it plays a direct role in the translocation of protons across the membrane
A7983_RS07755	COG3312	ion transport
A7983_RS07760	COG0357	Ribosomal RNA small subunit methyltransferase G
A7983_RS07765	COG0445	tRNA wobble uridine modification
A7983_RS07770	COG0716	FMN binding
A7983_RS07775	COG1522	sequence-specific DNA binding
A7983_RS07780	COG2502	aspartate--ammonia ligase
A7983_RS07785	COG2425	protein containing a von Willebrand factor type A (vWA) domain
A7983_RS07790	COG0714	Associated with various cellular activities
A7983_RS07795	COG3158	transport of potassium into the cell
A7983_RS07810	COG3111	PFAM Bacterial OB fold (BOF) protein
A7983_RS07815	COG1869	D-ribose catabolic process
A7983_RS07820	COG1129	ABC transporter
A7983_RS07825	COG1172	Belongs to the binding-protein-dependent transport system permease family
A7983_RS07835	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A7983_RS07840	COG1609	Transcriptional regulator
A7983_RS07865	COG1763	Mo-molybdopterin cofactor biosynthetic process
A7983_RS07870	COG0746	molybdenum cofactor guanylyltransferase activity
A7983_RS07875	COG3084	Protein conserved in bacteria
A7983_RS07880	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
A7983_RS07890	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A7983_RS07890	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A7983_RS07895	COG0218	Necessary for normal cell division and for the maintenance of normal septation
A7983_RS07900	COG3078	GTPase activator activity
A7983_RS07905	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A7983_RS07915	COG3852	Histidine kinase
A7983_RS07930	COG1011	Hydrolase
A7983_RS07935	COG1490	D-aminoacyl-tRNA deacylase activity
A7983_RS07940	COG0456	acetyltransferase
A7983_RS07945	COG2982	Protein involved in outer membrane biogenesis
A7983_RS07950	COG2233	PERMEase
A7983_RS07955	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A7983_RS07960	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A7983_RS07965	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A7983_RS07970	COG1758	RNA polymerase activity
A7983_RS07975	COG0194	GDP metabolic process
A7983_RS07980	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A7983_RS07985	COG2194	sulfuric ester hydrolase activity
A7983_RS08000	COG2200	EAL domain
A7983_RS08005	COG2081	HI0933 family
A7983_RS08010	COG0306	phosphate transporter
A7983_RS08020	COG0589	response to stress
A7983_RS08025	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A7983_RS08045	COG0737	Belongs to the 5'-nucleotidase family
A7983_RS08050	COG0742	ribosomal rna small subunit methyltransferase
A7983_RS08075	COG0443	Heat shock 70 kDa protein
A7983_RS08080	COG2214	Heat shock protein DnaJ domain protein
A7983_RS08105	COG3561	AntA/AntB antirepressor
A7983_RS08190	COG0741	lytic transglycosylase activity
A7983_RS08190	COG0739	heme binding
A7983_RS08190	COG1196	nuclear chromosome segregation
A7983_RS08210	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
A7983_RS08215	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A7983_RS08245	COG3479	Phenolic acid decarboxylase
A7983_RS08260	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A7983_RS08265	COG4172	Belongs to the ABC transporter superfamily
A7983_RS08270	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A7983_RS08275	COG0601	transmembrane transport
A7983_RS08280	COG0747	negative chemotaxis
A7983_RS08290	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A7983_RS08295	COG0840	transmembrane signaling receptor activity
A7983_RS08300	COG0456	acetyltransferase
A7983_RS08305	COG2818	Glycosylase
A7983_RS08310	COG0730	response to heat
A7983_RS08315	COG0752	glycyl-tRNA synthetase alpha subunit
A7983_RS08320	COG0751	glycine-tRNA ligase activity
A7983_RS08330	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
A7983_RS08330	COG2213	PTS system mannitol-specific
A7983_RS08335	COG0246	Mannitol dehydrogenase
A7983_RS08340	COG3722	fumarate hydratase activity
A7983_RS08350	COG0840	transmembrane signaling receptor activity
A7983_RS08355	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A7983_RS08360	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
A7983_RS08365	COG1012	belongs to the aldehyde dehydrogenase family
A7983_RS08370	COG3274	enterobacterial common antigen metabolic process
A7983_RS08375	COG1070	Carbohydrate kinase
A7983_RS08380	COG2115	Belongs to the xylose isomerase family
A7983_RS08385	COG4213	ABC transporter substrate-binding protein
A7983_RS08390	COG1129	ABC transporter
A7983_RS08395	COG4214	carbohydrate transport
A7983_RS08400	COG1609	Transcriptional regulator
A7983_RS08400	COG2207	Transcriptional regulator
A7983_RS08410	COG0137	argininosuccinate synthase activity
A7983_RS08415	COG3916	Acyl-homoserine-lactone synthase
A7983_RS08420	COG2771	luxR family
A7983_RS08425	COG4677	pectinesterase activity
A7983_RS08430	COG3136	membrane protein required for alginate biosynthesis
A7983_RS08435	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A7983_RS08440	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A7983_RS08470	COG3239	Fatty acid desaturase
A7983_RS08480	COG1012	belongs to the aldehyde dehydrogenase family
A7983_RS08485	COG1304	FMN binding
A7983_RS08490	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
A7983_RS08490	COG0456	acetyltransferase
A7983_RS08495	COG0628	permease
A7983_RS08525	COG1561	YicC-like family, N-terminal region
A7983_RS08530	COG0583	DNA-binding transcription factor activity
A7983_RS08535	COG1446	asparaginase
A7983_RS08550	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A7983_RS08555	COG0601	transmembrane transport
A7983_RS08560	COG0747	negative chemotaxis
A7983_RS08565	COG4172	Belongs to the ABC transporter superfamily
A7983_RS08570	COG4948	Mandelate Racemase Muconate Lactonizing
A7983_RS08575	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
A7983_RS08580	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A7983_RS08585	COG1309	transcriptional regulator
A7983_RS08590	COG0756	dUTP diphosphatase activity
A7983_RS08595	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A7983_RS08600	COG2003	Belongs to the UPF0758 family
A7983_RS08605	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A7983_RS08615	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A7983_RS08625	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A7983_RS08630	COG1519	Transferase
A7983_RS08650	COG0562	UDP-galactopyranose mutase
A7983_RS08670	COG0438	transferase activity, transferring glycosyl groups
A7983_RS08675	COG0515	serine threonine protein kinase
A7983_RS08680	COG0438	transferase activity, transferring glycosyl groups
A7983_RS08685	COG0859	PFAM glycosyl transferase family 9
A7983_RS08700	COG3307	-O-antigen
A7983_RS08705	COG0859	PFAM glycosyl transferase family 9
A7983_RS08715	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A7983_RS08720	COG0156	8-amino-7-oxononanoate synthase activity
A7983_RS08725	COG1063	alcohol dehydrogenase
A7983_RS08730	COG2861	carbohydrate metabolic process
A7983_RS08735	COG4942	peptidase
A7983_RS08740	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A7983_RS08745	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
A7983_RS08750	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A7983_RS08755	COG1045	serine acetyltransferase
A7983_RS08770	COG0583	DNA-binding transcription factor activity
A7983_RS08775	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A7983_RS08780	COG0840	transmembrane signaling receptor activity
A7983_RS08785	COG0840	transmembrane signaling receptor activity
A7983_RS08790	COG0412	Dienelactone hydrolase
A7983_RS08805	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
A7983_RS08880	COG1116	anion transmembrane transporter activity
A7983_RS08885	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A7983_RS08925	COG0583	DNA-binding transcription factor activity
A7983_RS09025	COG3209	COG3209 Rhs family protein
A7983_RS09060	COG3209	COG3209 Rhs family protein
A7983_RS09090	COG3209	COG3209 Rhs family protein
A7983_RS09125	COG3501	Rhs element vgr protein
A7983_RS09135	COG1263	PTS System
A7983_RS09135	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A7983_RS09135	COG2190	(PTS) system
A7983_RS09140	COG4948	Mandelate Racemase Muconate Lactonizing
A7983_RS09145	COG2188	Transcriptional regulator
A7983_RS09150	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A7983_RS09155	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A7983_RS09160	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A7983_RS09165	COG0165	Argininosuccinate lyase
A7983_RS09170	COG1322	Protein conserved in bacteria
A7983_RS09175	COG2226	methyltransferase
A7983_RS09190	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A7983_RS09195	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A7983_RS09200	COG0805	protein transport
A7983_RS09205	COG0084	hydrolase, TatD family'
A7983_RS09215	COG0250	Participates in transcription elongation, termination and antitermination
A7983_RS09220	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
A7983_RS09235	COG0183	Belongs to the thiolase family
A7983_RS09240	COG1250	3-hydroxyacyl-CoA dehydrogenase
A7983_RS09240	COG1024	Enoyl-CoA hydratase
A7983_RS09245	COG0006	proline dipeptidase activity
A7983_RS09250	COG1739	Uncharacterized protein family UPF0029
A7983_RS09290	COG1126	abc transporter atp-binding protein
A7983_RS09295	COG0765	amino acid transport
A7983_RS09300	COG4597	amino acid ABC transporter
A7983_RS09305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7983_RS09310	COG0765	amino acid transport
A7983_RS09315	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7983_RS09340	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
A7983_RS09355	COG2264	protein methyltransferase activity
A7983_RS09360	COG4145	pantothenate transmembrane transporter activity
A7983_RS09365	COG3924	membrane
A7983_RS09370	COG3585	molybdate ion transport
A7983_RS09380	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A7983_RS09385	COG1120	ATPase activity
A7983_RS09390	COG0500	methyltransferase
A7983_RS09395	COG0157	Belongs to the NadC ModD family
A7983_RS09405	COG0439	Biotin carboxylase
A7983_RS09410	COG0511	ligase activity, forming carbon-carbon bonds
A7983_RS09415	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
A7983_RS09420	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
A7983_RS09425	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A7983_RS09440	COG0604	alcohol dehydrogenase
A7983_RS09445	COG2199	diguanylate cyclase activity
A7983_RS09445	COG2200	EAL domain
A7983_RS09450	COG1077	Cell shape determining protein MreB Mrl
A7983_RS09455	COG1792	Involved in formation and maintenance of cell shape
A7983_RS09460	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
A7983_RS09465	COG0424	maF-like protein
A7983_RS09470	COG1530	ribonuclease E activity
A7983_RS09475	COG3164	Protein of unknown function
A7983_RS09480	COG0312	modulator of DNA gyrase
A7983_RS09485	COG0583	DNA-binding transcription factor activity
A7983_RS09495	COG1566	PFAM secretion protein HlyD family protein
A7983_RS09500	COG1289	transmembrane transporter activity
A7983_RS09505	COG3028	Belongs to the UPF0307 family
A7983_RS09510	COG0312	modulator of DNA gyrase
A7983_RS09515	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A7983_RS09520	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A7983_RS09525	COG1660	Displays ATPase and GTPase activities
A7983_RS09530	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A7983_RS09535	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A7983_RS09540	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
A7983_RS09545	COG1137	ATPase activity
A7983_RS09550	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
A7983_RS09555	COG3117	lipopolysaccharide transmembrane transporter activity
A7983_RS09560	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
A7983_RS09565	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
A7983_RS09565	COG0517	IMP dehydrogenase activity
A7983_RS09570	COG0530	calcium, potassium:sodium antiporter activity
A7983_RS09575	COG1127	ABC transporter
A7983_RS09580	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A7983_RS09585	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A7983_RS09590	COG2854	intermembrane phospholipid transfer
A7983_RS09595	COG3113	response to antibiotic
A7983_RS09600	COG5007	Belongs to the BolA IbaG family
A7983_RS09605	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A7983_RS09610	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A7983_RS09615	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A7983_RS09620	COG3105	Protein conserved in bacteria
A7983_RS09625	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
A7983_RS09630	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A7983_RS09635	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A7983_RS09640	COG0477	Major facilitator Superfamily
A7983_RS09645	COG1063	alcohol dehydrogenase
A7983_RS09650	COG1028	Short-chain dehydrogenase reductase Sdr
A7983_RS09665	COG0625	glutathione transferase activity
A7983_RS09670	COG2969	positive regulation of protein catabolic process
A7983_RS09680	COG0493	'glutamate synthase
A7983_RS09685	COG0067	glutamate synthase
A7983_RS09685	COG0070	glutamate synthase
A7983_RS09685	COG0069	glutamate synthase activity
A7983_RS09690	COG1242	4 iron, 4 sulfur cluster binding
A7983_RS09695	COG5002	protein histidine kinase activity
A7983_RS09695	COG0784	Response regulator, receiver
A7983_RS09695	COG2198	Histidine kinase
A7983_RS09700	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
A7983_RS09705	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A7983_RS09715	COG2823	Periplasmic or secreted lipoprotein
A7983_RS09720	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
A7983_RS09725	COG0792	nuclease activity
A7983_RS09730	COG3107	peptidoglycan biosynthetic process
A7983_RS09735	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A7983_RS09755	COG3384	dioxygenase
A7983_RS09760	COG0754	glutathionylspermidine amidase activity
A7983_RS09765	COG5463	Belongs to the UPF0441 family
A7983_RS09775	COG0494	nUDIX hydrolase
A7983_RS09780	COG3151	Protein conserved in bacteria
A7983_RS09785	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
A7983_RS09790	COG3150	esterase
A7983_RS09800	COG0583	DNA-binding transcription factor activity
A7983_RS09805	COG2249	NAD(P)H dehydrogenase (quinone) activity
A7983_RS09820	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A7983_RS09820	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A7983_RS09825	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A7983_RS09830	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A7983_RS09830	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A7983_RS09830	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A7983_RS09835	COG3711	transcriptional antiterminator
A7983_RS09845	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A7983_RS09850	COG0204	Acyl-transferase
A7983_RS09855	COG2132	Multicopper oxidase
A7983_RS09865	COG0656	L-ascorbic acid biosynthetic process
A7983_RS09875	COG3501	Rhs element vgr protein
A7983_RS09900	COG1979	alcohol dehydrogenase
A7983_RS09905	COG0778	Nitroreductase
A7983_RS09910	COG2207	Transcriptional regulator
A7983_RS09915	COG0586	Pfam SNARE associated Golgi protein
A7983_RS09935	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A7983_RS09945	COG0848	biopolymer transport protein
A7983_RS09990	COG1203	CRISPR-associated helicase, Cas3
A7983_RS10015	COG1857	crispr-associated protein
A7983_RS10030	COG1518	maintenance of DNA repeat elements
A7983_RS10035	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A7983_RS10045	COG4680	protein conserved in bacteria
A7983_RS10060	COG0076	glutamate decarboxylase activity
A7983_RS10065	COG2814	Major facilitator Superfamily
A7983_RS10075	COG3787	Belongs to the UPF0306 family
A7983_RS10080	COG0702	epimerase
A7983_RS10085	COG0602	queuosine metabolic process
A7983_RS10090	COG1328	CTP reductase activity
A7983_RS10100	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
A7983_RS10105	COG0540	Belongs to the ATCase OTCase family
A7983_RS10110	COG2731	YhcH YjgK YiaL family protein
A7983_RS10125	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A7983_RS10145	COG0501	Belongs to the peptidase M48B family
A7983_RS10150	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A7983_RS10155	COG0840	transmembrane signaling receptor activity
A7983_RS10160	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
A7983_RS10165	COG0525	valine-tRNA ligase activity
A7983_RS10170	COG2927	DNA polymerase III (CHI subunit)
A7983_RS10175	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A7983_RS10180	COG0795	lipopolysaccharide-transporting ATPase activity
A7983_RS10185	COG0795	lipopolysaccharide-transporting ATPase activity
A7983_RS10195	COG0582	viral genome integration into host DNA
A7983_RS10275	COG2026	Addiction module toxin, RelE StbE family
A7983_RS10280	COG0582	viral genome integration into host DNA
A7983_RS10285	COG2801	Transposase and inactivated derivatives
A7983_RS10365	COG1262	PFAM Formylglycine-generating sulfatase enzyme
A7983_RS10375	COG1136	(ABC) transporter
A7983_RS10405	COG2304	oxidoreductase activity
A7983_RS10410	COG2850	peptidyl-arginine hydroxylation
A7983_RS10430	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A7983_RS10450	COG0583	DNA-binding transcription factor activity
A7983_RS10465	COG4650	regulator
A7983_RS10470	COG1690	Belongs to the RtcB family
A7983_RS10475	COG3541	Predicted nucleotidyltransferase
A7983_RS10495	COG0840	transmembrane signaling receptor activity
A7983_RS10505	COG0840	transmembrane signaling receptor activity
A7983_RS10510	COG3254	rhamnose metabolic process
A7983_RS10515	COG0235	Class ii aldolase
A7983_RS10520	COG4806	L-rhamnose isomerase
A7983_RS10525	COG1070	Carbohydrate kinase
A7983_RS10530	COG1917	Cupin 2, conserved barrel domain protein
A7983_RS10530	COG2169	Transcriptional regulator
A7983_RS10535	COG1917	Cupin 2, conserved barrel domain protein
A7983_RS10535	COG4977	sequence-specific DNA binding
A7983_RS10540	COG4115	mRNA cleavage
A7983_RS10545	COG2161	toxin-antitoxin pair type II binding
A7983_RS10555	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A7983_RS10560	COG0601	transmembrane transport
A7983_RS10565	COG0747	negative chemotaxis
A7983_RS10570	COG3477	response to acidic pH
A7983_RS10595	COG2862	Uncharacterized protein family, UPF0114
A7983_RS10600	COG2130	NADP-dependent
A7983_RS10640	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A7983_RS10645	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A7983_RS10650	COG0006	proline dipeptidase activity
A7983_RS10655	COG3079	Belongs to the UPF0149 family
A7983_RS10660	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
A7983_RS10670	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A7983_RS10685	COG0560	Phosphoserine phosphatase
A7983_RS10690	COG3726	membrane protein affecting hemolysin expression
A7983_RS10695	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
A7983_RS10700	COG2823	Periplasmic or secreted lipoprotein
A7983_RS10705	COG5487	UPF0391 membrane protein
A7983_RS10715	COG0084	hydrolase, TatD family'
A7983_RS10720	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A7983_RS10730	COG4771	TonB-dependent receptor
A7983_RS10740	COG1169	isochorismate synthase
A7983_RS10745	COG1021	2,3-dihydroxybenzoate-AMP ligase
A7983_RS10750	COG1028	Short-chain dehydrogenase reductase Sdr
A7983_RS10800	COG3624	Phosphonate C-P lyase system protein PhnG
A7983_RS10805	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
A7983_RS10810	COG3626	phosphonate metabolism
A7983_RS10815	COG3627	carbon phosphorus lyase activity
A7983_RS10820	COG4107	phosphonate C-P lyase system protein PhnK
A7983_RS10825	COG4778	phosphonate C-P lyase system protein PhnL
A7983_RS10830	COG3454	Phosphonate metabolism
A7983_RS10835	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
A7983_RS10840	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A7983_RS10880	COG0297	glycogen (starch) synthase activity
A7983_RS10885	COG0438	transferase activity, transferring glycosyl groups
A7983_RS10900	COG1045	serine acetyltransferase
A7983_RS10920	COG3423	Transcriptional regulator
A7983_RS10925	COG2255	four-way junction helicase activity
A7983_RS10940	COG1404	Belongs to the peptidase S8 family
A7983_RS10955	COG3423	Transcriptional regulator
A7983_RS10960	COG0582	viral genome integration into host DNA
A7983_RS10980	COG1309	transcriptional regulator
A7983_RS10985	COG4232	protein-disulfide reductase activity
A7983_RS10990	COG1324	tolerance protein
A7983_RS10995	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
A7983_RS11010	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A7983_RS11020	COG3161	chorismate lyase activity
A7983_RS11025	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
A7983_RS11030	COG2937	Belongs to the GPAT DAPAT family
A7983_RS11035	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
A7983_RS11045	COG0735	belongs to the Fur family
A7983_RS11050	COG1741	Belongs to the pirin family
A7983_RS11055	COG0583	DNA-binding transcription factor activity
A7983_RS11060	COG0435	Glutathione S-transferase
A7983_RS11065	COG2259	Doxx family
A7983_RS11075	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
A7983_RS11080	COG4575	ribosome binding
A7983_RS11090	COG0586	Pfam SNARE associated Golgi protein
A7983_RS11100	COG2271	Major facilitator Superfamily
A7983_RS11105	COG1904	glucuronate isomerase
A7983_RS11110	COG0246	Mannitol dehydrogenase
A7983_RS11115	COG2721	sulfolactate sulfo-lyase activity
A7983_RS11125	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
A7983_RS11135	COG0673	inositol 2-dehydrogenase activity
A7983_RS11140	COG2813	Specifically methylates the guanine in position
A7983_RS11145	COG0446	pyridine nucleotide-disulphide oxidoreductase
A7983_RS11145	COG1902	pentaerythritol trinitrate reductase activity
A7983_RS11155	COG3678	ATP-independent chaperone mediated protein folding
A7983_RS11160	COG2199	diguanylate cyclase activity
A7983_RS11185	COG3119	arylsulfatase activity
A7983_RS11190	COG0641	radical SAM
A7983_RS11195	COG3119	arylsulfatase activity
A7983_RS11195	COG3408	Glycogen debranching enzyme
A7983_RS11200	COG2723	6-phospho-beta-galactosidase activity
A7983_RS11210	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A7983_RS11215	COG1554	hydrolase, family 65, central catalytic
A7983_RS11220	COG1263	PTS System
A7983_RS11220	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A7983_RS11225	COG1609	Transcriptional regulator
A7983_RS11245	COG0583	DNA-binding transcription factor activity
A7983_RS11250	COG2188	Transcriptional regulator
A7983_RS11260	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A7983_RS11290	COG2963	transposase activity
A7983_RS11405	COG3663	DNA glycosylase
A7983_RS11415	COG0358	DNA primase activity
A7983_RS11420	COG0828	Belongs to the bacterial ribosomal protein bS21 family
A7983_RS11425	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A7983_RS11430	COG1438	arginine binding
A7983_RS11435	COG0039	L-malate dehydrogenase activity
A7983_RS11440	COG3423	Transcriptional regulator
A7983_RS11455	COG0142	geranyltranstransferase activity
A7983_RS11460	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A7983_RS11465	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A7983_RS11470	COG0697	spore germination
A7983_RS11475	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A7983_RS11480	COG2027	D-alanyl-D-alanine carboxypeptidase
A7983_RS11490	COG1534	Rna-binding protein
A7983_RS11500	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A7983_RS11505	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A7983_RS11510	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A7983_RS11515	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A7983_RS11530	COG0779	Required for maturation of 30S ribosomal subunits
A7983_RS11540	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A7983_RS11545	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A7983_RS11550	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A7983_RS11555	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A7983_RS11560	COG1185	polyribonucleotide nucleotidyltransferase activity
A7983_RS11570	COG0513	Belongs to the DEAD box helicase family
A7983_RS11575	COG2194	sulfuric ester hydrolase activity
A7983_RS11580	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A7983_RS11585	COG0826	peptidase U32
A7983_RS11590	COG0826	peptidase U32
A7983_RS11595	COG3154	lipid carrier protein
A7983_RS11600	COG3153	acetyltransferase
A7983_RS11605	COG2827	Endonuclease containing a URI domain
A7983_RS11610	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
A7983_RS11615	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
A7983_RS11620	COG0813	purine-nucleoside phosphorylase activity
A7983_RS11635	COG0456	acetyltransferase
A7983_RS11640	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
A7983_RS11645	COG2813	Specifically methylates the guanine in position
A7983_RS11650	COG0656	L-ascorbic acid biosynthetic process
A7983_RS11695	COG1454	alcohol dehydrogenase
A7983_RS11700	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A7983_RS11705	COG0509	glycine decarboxylation via glycine cleavage system
A7983_RS11710	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A7983_RS11710	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A7983_RS11715	COG1733	regulation of RNA biosynthetic process
A7983_RS11720	COG1028	Short-chain dehydrogenase reductase Sdr
A7983_RS11725	COG1175	transmembrane transport
A7983_RS11735	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
A7983_RS11745	COG1653	transport
A7983_RS11750	COG4773	Receptor
A7983_RS11760	COG1272	protein, Hemolysin III
A7983_RS11765	COG0354	folic acid binding
A7983_RS11770	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
A7983_RS11780	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
A7983_RS11790	COG0716	FMN binding
A7983_RS11795	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A7983_RS11800	COG2011	ABC-type metal ion transport system permease component
A7983_RS11805	COG1464	Belongs to the NlpA lipoprotein family
A7983_RS11810	COG0477	Major facilitator Superfamily
A7983_RS11815	COG4974	Belongs to the 'phage' integrase family
A7983_RS11820	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A7983_RS11825	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A7983_RS11830	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A7983_RS11835	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A7983_RS11865	COG1560	Kdo2-lipid A biosynthetic process
A7983_RS11875	COG2252	PERMEase
A7983_RS11880	COG0025	NhaP-type Na H and K H
A7983_RS11890	COG3850	Histidine kinase
A7983_RS11890	COG5002	protein histidine kinase activity
A7983_RS11910	COG4964	Belongs to the GSP D family
A7983_RS11995	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A7983_RS12000	COG3162	membrane
A7983_RS12005	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A7983_RS12020	COG3711	transcriptional antiterminator
A7983_RS12020	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A7983_RS12035	COG3964	amidohydrolase
A7983_RS12070	COG3712	iron ion homeostasis
A7983_RS12090	COG0246	Mannitol dehydrogenase
A7983_RS12095	COG2873	o-acetylhomoserine
A7983_RS12100	COG1376	ErfK ybiS ycfS ynhG family protein
A7983_RS12105	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A7983_RS12110	COG3038	cytochrome b561
A7983_RS12115	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A7983_RS12115	COG0674	pyruvate-flavodoxin oxidoreductase activity
A7983_RS12115	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
A7983_RS12115	COG1013	pyruvate-flavodoxin oxidoreductase activity
A7983_RS12130	COG2211	Major facilitator Superfamily
A7983_RS12140	COG1280	lysine exporter protein (LysE YggA)
A7983_RS12170	COG0582	viral genome integration into host DNA
A7983_RS12180	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A7983_RS12185	COG2867	negative regulation of translational initiation
A7983_RS12190	COG2914	Belongs to the UPF0125 (RnfH) family
A7983_RS12200	COG0497	DNA recombination
A7983_RS12205	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A7983_RS12210	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A7983_RS12215	COG1914	H( )-stimulated, divalent metal cation uptake system
A7983_RS12235	COG1942	4-Oxalocrotonate Tautomerase
A7983_RS12240	COG0494	nUDIX hydrolase
A7983_RS12250	COG0814	amino acid
A7983_RS12255	COG1671	Belongs to the UPF0178 family
A7983_RS12260	COG0408	coproporphyrinogen oxidase activity
A7983_RS12265	COG0456	acetyltransferase
A7983_RS12280	COG4771	TonB-dependent receptor
A7983_RS12285	COG0612	Peptidase, M16
A7983_RS12290	COG4178	(ABC) transporter
A7983_RS12300	COG2837	iron assimilation
A7983_RS12305	COG4150	thiosulfate binding
A7983_RS12310	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
A7983_RS12315	COG4208	sulfate ABC transporter
A7983_RS12320	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A7983_RS12325	COG1136	(ABC) transporter
A7983_RS12325	COG0577	efflux transmembrane transporter activity
A7983_RS12330	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A7983_RS12335	COG0745	RESPONSE REGULATOR receiver
A7983_RS12340	COG2205	protein histidine kinase activity
A7983_RS12345	COG2190	(PTS) system
A7983_RS12355	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A7983_RS12370	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
A7983_RS12375	COG3115	cell septum assembly
A7983_RS12380	COG0531	amino acid
A7983_RS12390	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A7983_RS12400	COG0446	pyridine nucleotide-disulphide oxidoreductase
A7983_RS12405	COG0426	domain, Protein
A7983_RS12405	COG1773	rubredoxin
A7983_RS12410	COG3604	Transcriptional regulator
A7983_RS12415	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
A7983_RS12415	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
A7983_RS12420	COG0583	DNA-binding transcription factor activity
A7983_RS12440	COG2169	Transcriptional regulator
A7983_RS12440	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A7983_RS12455	COG0431	NADPH-dependent FMN reductase
A7983_RS12455	COG1053	succinate dehydrogenase
A7983_RS12455	COG3976	FMN-binding domain protein
A7983_RS12460	COG0477	Major facilitator Superfamily
A7983_RS12465	COG3301	Polysulphide reductase, NrfD
A7983_RS12470	COG0437	4 iron, 4 sulfur cluster binding
A7983_RS12480	COG0583	DNA-binding transcription factor activity
A7983_RS12485	COG4948	Mandelate Racemase Muconate Lactonizing
A7983_RS12490	COG1063	alcohol dehydrogenase
A7983_RS12495	COG2211	Major facilitator Superfamily
A7983_RS12510	COG0246	Mannitol dehydrogenase
A7983_RS12520	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A7983_RS12530	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A7983_RS12535	COG1802	Transcriptional regulator
A7983_RS12545	COG2814	Major facilitator Superfamily
A7983_RS12570	COG0673	inositol 2-dehydrogenase activity
A7983_RS12575	COG2897	thiosulfate sulfurtransferase activity
A7983_RS12580	COG1126	abc transporter atp-binding protein
A7983_RS12585	COG0765	amino acid transport
A7983_RS12590	COG0765	amino acid transport
A7983_RS12595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7983_RS12605	COG0626	cystathionine gamma-synthase activity
A7983_RS12610	COG2843	Capsule synthesis protein
A7983_RS12615	COG4773	Receptor
A7983_RS12635	COG3121	Chaperone
A7983_RS12680	COG2249	NAD(P)H dehydrogenase (quinone) activity
A7983_RS12710	COG3842	ATPase activity
A7983_RS12715	COG1176	ABC-type spermidine putrescine transport system, permease component I
A7983_RS12780	COG3829	transcription factor binding
A7983_RS12910	COG2999	glutathione oxidoreductase activity
A7983_RS12915	COG0583	DNA-binding transcription factor activity
A7983_RS12920	COG2814	Major facilitator Superfamily
A7983_RS12945	COG1546	Belongs to the CinA family
A7983_RS12950	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A7983_RS12955	COG2137	regulation of response to DNA damage stimulus
A7983_RS12960	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A7983_RS12965	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
A7983_RS12990	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A7983_RS12995	COG1238	metal cluster binding
A7983_RS13000	COG2918	glutathione biosynthetic process
A7983_RS13005	COG1854	S-ribosylhomocysteine lyase activity
A7983_RS13010	COG4137	Cytochrome C assembly protein
A7983_RS13015	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A7983_RS13020	COG0228	four-way junction DNA binding
A7983_RS13025	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A7983_RS13030	COG0336	Belongs to the RNA methyltransferase TrmD family
A7983_RS13035	COG0335	large ribosomal subunit rRNA binding
A7983_RS13040	COG2264	protein methyltransferase activity
A7983_RS13050	COG3279	Response regulator of the LytR AlgR family
A7983_RS13055	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A7983_RS13060	COG1605	Chorismate mutase
A7983_RS13060	COG0287	Prephenate dehydrogenase
A7983_RS13065	COG1605	Chorismate mutase
A7983_RS13065	COG0077	Prephenate dehydratase
A7983_RS13070	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A7983_RS13075	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A7983_RS13080	COG0564	pseudouridine synthase activity
A7983_RS13125	COG0477	Major facilitator Superfamily
A7983_RS13130	COG5544	Lipoprotein
A7983_RS13135	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A7983_RS13140	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A7983_RS13140	COG1042	CoA-binding domain protein
A7983_RS13140	COG0045	succinate-CoA ligase (ADP-forming) activity
A7983_RS13145	COG3148	PFAM DTW domain containing protein
A7983_RS13150	COG3118	belongs to the thioredoxin family
A7983_RS13155	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A7983_RS13165	COG2814	Major facilitator Superfamily
A7983_RS13170	COG1566	PFAM secretion protein HlyD family protein
A7983_RS13175	COG1846	Transcriptional regulator
A7983_RS13185	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
A7983_RS13190	COG2814	Major facilitator Superfamily
A7983_RS13200	COG2113	Glycine betaine
A7983_RS13205	COG4176	ABC-type proline glycine betaine transport system permease component
A7983_RS13210	COG4175	Glycine betaine
A7983_RS13255	COG0765	amino acid transport
A7983_RS13265	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A7983_RS13275	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A7983_RS13280	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A7983_RS13285	COG1882	Formate acetyltransferase
A7983_RS13290	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A7983_RS13300	COG0436	Aminotransferase
A7983_RS13305	COG0235	Class ii aldolase
A7983_RS13310	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
A7983_RS13315	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
A7983_RS13320	COG3501	Rhs element vgr protein
A7983_RS13365	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
A7983_RS13370	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
A7983_RS13380	COG1960	acyl-CoA dehydrogenase activity
A7983_RS13385	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
A7983_RS13390	COG0121	glutamine amidotransferase
A7983_RS13395	COG3034	peptidoglycan biosynthetic process
A7983_RS13400	COG2226	methyltransferase
A7983_RS13410	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A7983_RS13415	COG2195	Cleaves the N-terminal amino acid of tripeptides
A7983_RS13420	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
A7983_RS13425	COG1073	alpha beta
A7983_RS13445	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A7983_RS13450	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
A7983_RS13480	COG3093	addiction module antidote protein HigA
A7983_RS13520	COG0582	viral genome integration into host DNA
A7983_RS13525	COG0582	viral genome integration into host DNA
A7983_RS13575	COG0484	heat shock protein binding
A7983_RS13580	COG0582	viral genome integration into host DNA
A7983_RS13590	COG1982	Orn Lys Arg decarboxylase major
A7983_RS13595	COG1113	amino acid transport
A7983_RS13615	COG5441	Belongs to the UPF0261 family
A7983_RS13620	COG5564	TIM-barrel signal transduction protein
A7983_RS13635	COG0741	lytic transglycosylase activity
A7983_RS13640	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
A7983_RS13645	COG1194	a g-specific adenine glycosylase
A7983_RS13650	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A7983_RS13655	COG3171	Protein conserved in bacteria
A7983_RS13665	COG0667	Aldo Keto reductase
A7983_RS13675	COG3066	DNA modification
A7983_RS13680	COG0494	nUDIX hydrolase
A7983_RS13690	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A7983_RS13695	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
A7983_RS13720	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
A7983_RS13725	COG1025	Belongs to the peptidase M16 family
A7983_RS13730	COG1074	ATP-dependent DNA helicase activity
A7983_RS13735	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A7983_RS13740	COG1609	Transcriptional regulator
A7983_RS13750	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
A7983_RS13750	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A7983_RS13755	COG0860	N-Acetylmuramoyl-L-alanine amidase
A7983_RS13775	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
A7983_RS13780	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A7983_RS13790	COG1473	amidohydrolase
A7983_RS13795	COG4172	Belongs to the ABC transporter superfamily
A7983_RS13800	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A7983_RS13810	COG0747	negative chemotaxis
A7983_RS13820	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A7983_RS13825	COG2166	iron-sulfur cluster assembly
A7983_RS13830	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A7983_RS13840	COG0583	DNA-binding transcription factor activity
A7983_RS13845	COG2363	Small membrane protein
A7983_RS13850	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
A7983_RS13855	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A7983_RS13860	COG1611	Belongs to the LOG family
A7983_RS13865	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
A7983_RS13865	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
A7983_RS13900	COG2171	N-acyltransferase activity
A7983_RS13905	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
A7983_RS13915	COG0052	Belongs to the universal ribosomal protein uS2 family
A7983_RS13920	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A7983_RS13925	COG0528	UMP kinase activity
A7983_RS13930	COG0233	cytoplasmic translational termination
A7983_RS13935	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
A7983_RS13940	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A7983_RS13945	COG0575	Belongs to the CDS family
A7983_RS13950	COG0750	zinc metalloprotease
A7983_RS13955	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A7983_RS13960	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
A7983_RS13965	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A7983_RS13970	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A7983_RS13975	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A7983_RS13980	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A7983_RS13985	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A7983_RS13990	COG0587	DNA-directed DNA polymerase activity
A7983_RS13995	COG0825	malonyl-CoA metabolic process
A7983_RS14000	COG0346	lactoylglutathione lyase activity
A7983_RS14005	COG0037	tRNA processing
A7983_RS14010	COG4568	rho-dependent transcription termination
A7983_RS14025	COG3015	lipoprotein NlpE involved in copper resistance
A7983_RS14030	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A7983_RS14035	COG4943	cyclic-guanylate-specific phosphodiesterase activity
A7983_RS14040	COG2824	Alkylphosphonate utilization operon protein PhnA
A7983_RS14045	COG2951	lytic endotransglycosylase activity
A7983_RS14055	COG0583	DNA-binding transcription factor activity
A7983_RS14085	COG2186	Transcriptional regulator
A7983_RS14090	COG1312	Catalyzes the dehydration of D-mannonate
A7983_RS14095	COG5297	Belongs to the glycosyl hydrolase family 6
A7983_RS14100	COG5434	Belongs to the glycosyl hydrolase 28 family
A7983_RS14110	COG1132	(ABC) transporter
A7983_RS14135	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A7983_RS14140	COG3123	guanosine phosphorylase activity
A7983_RS14145	COG2211	Major facilitator Superfamily
A7983_RS14155	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A7983_RS14160	COG2188	Transcriptional regulator
A7983_RS14170	COG2974	May be involved in recombination
A7983_RS14175	COG1940	carbohydrate kinase activity
A7983_RS14180	COG0419	ATPase involved in DNA repair
A7983_RS14185	COG0420	3'-5' exonuclease activity
A7983_RS14205	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A7983_RS14220	COG0668	transmembrane transport
A7983_RS14225	COG0450	alkyl hydroperoxide reductase
A7983_RS14230	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
A7983_RS14235	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A7983_RS14240	COG0343	queuine tRNA-ribosyltransferase activity
A7983_RS14245	COG1862	Preprotein translocase
A7983_RS14250	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A7983_RS14255	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A7983_RS14260	COG4238	major outer membrane lipoprotein
A7983_RS14265	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A7983_RS14270	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A7983_RS14270	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A7983_RS14275	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
A7983_RS14280	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A7983_RS14285	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
A7983_RS14290	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A7983_RS14295	COG0142	geranyltranstransferase activity
A7983_RS14300	COG1722	exodeoxyribonuclease VII activity
A7983_RS14310	COG0301	tRNA thio-modification
A7983_RS14310	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A7983_RS14315	COG0693	protein deglycase activity
A7983_RS14320	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A7983_RS14325	COG1666	GTP binding
A7983_RS14330	COG2814	Major facilitator Superfamily
A7983_RS14335	COG0109	protoheme IX farnesyltransferase activity
A7983_RS14340	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
A7983_RS14345	COG1845	cytochrome c oxidase, subunit III
A7983_RS14350	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A7983_RS14355	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A7983_RS14365	COG3056	Lipoprotein
A7983_RS14370	COG0271	Belongs to the BolA IbaG family
A7983_RS14375	COG0544	peptidyl-prolyl cis-trans isomerase activity
A7983_RS14380	COG0740	serine-type endopeptidase activity
A7983_RS14385	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A7983_RS14390	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A7983_RS14395	COG0776	regulation of translation
A7983_RS14400	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A7983_RS14405	COG1555	photosystem II stabilization
A7983_RS14410	COG0824	Thioesterase
A7983_RS14415	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
A7983_RS14420	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A7983_RS14430	COG1522	sequence-specific DNA binding
A7983_RS14435	COG1132	(ABC) transporter
A7983_RS14440	COG1132	(ABC) transporter
A7983_RS14445	COG0347	Belongs to the P(II) protein family
A7983_RS14450	COG0004	ammonium transporteR
A7983_RS14455	COG1946	Acyl-CoA thioesterase
A7983_RS14460	COG3126	Type III secretion system lipoprotein chaperone (YscW)
A7983_RS14465	COG3695	enzyme binding
A7983_RS14485	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A7983_RS14490	COG0254	rRNA binding
A7983_RS14495	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A7983_RS14500	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A7983_RS14505	COG1309	transcriptional regulator
A7983_RS14520	COG2832	Protein of unknown function (DUF454)
A7983_RS14525	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A7983_RS14535	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A7983_RS14540	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A7983_RS14545	COG0326	Molecular chaperone. Has ATPase activity
A7983_RS14550	COG0563	adenylate kinase activity
A7983_RS14555	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
A7983_RS14560	COG4651	solute:proton antiporter activity
A7983_RS14560	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A7983_RS14565	COG0737	Belongs to the 5'-nucleotidase family
A7983_RS14575	COG1966	Carbon starvation protein
A7983_RS14580	COG2879	small protein
A7983_RS14585	COG0523	cobalamin synthesis protein
A7983_RS14590	COG5434	Belongs to the glycosyl hydrolase 28 family
A7983_RS14600	COG3735	TraB family
A7983_RS14605	COG2217	Heavy metal translocating P-type atpase
A7983_RS14620	COG1585	Membrane protein implicated in regulation of membrane protease activity
A7983_RS14625	COG0330	HflC and HflK could
A7983_RS14630	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A7983_RS14635	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A7983_RS14640	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A7983_RS14645	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A7983_RS14655	COG2205	protein histidine kinase activity
A7983_RS14655	COG0784	Response regulator, receiver
A7983_RS14660	COG2197	response regulator
A7983_RS14665	COG2198	Histidine kinase
A7983_RS14665	COG0642	Histidine kinase
A7983_RS14670	COG2223	nitrite transmembrane transporter activity
A7983_RS14675	COG1733	regulation of RNA biosynthetic process
A7983_RS14680	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
A7983_RS14685	COG1028	Short-chain dehydrogenase reductase Sdr
A7983_RS14690	COG1028	Short-chain dehydrogenase reductase Sdr
A7983_RS14695	COG1169	isochorismate synthase
A7983_RS14700	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
A7983_RS14705	COG0596	Alpha beta hydrolase
A7983_RS14710	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
A7983_RS14715	COG1441	menaquinone biosynthetic process
A7983_RS14730	COG0814	amino acid
A7983_RS14740	COG3118	belongs to the thioredoxin family
A7983_RS14745	COG0300	oxidoreductase activity
A7983_RS14750	COG2755	lipolytic protein G-D-S-L family
A7983_RS14755	COG4181	ATPase activity
A7983_RS14760	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
A7983_RS14765	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A7983_RS14770	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A7983_RS14775	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A7983_RS14780	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A7983_RS14785	COG2233	PERMEase
A7983_RS14790	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A7983_RS14795	COG1393	Belongs to the ArsC family
A7983_RS14800	COG4783	chaperone-mediated protein folding
A7983_RS14805	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A7983_RS14810	COG2716	regulation of RNA biosynthetic process
A7983_RS14815	COG0662	Cupin 2, conserved barrel domain protein
A7983_RS14825	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
A7983_RS14830	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A7983_RS14835	COG2707	UPF0756 membrane protein
A7983_RS14840	COG1444	tRNA N-acetyltransferase activity
A7983_RS14845	COG3813	Protein conserved in bacteria
A7983_RS14850	COG0400	carboxylic ester hydrolase activity
A7983_RS14860	COG0183	Belongs to the thiolase family
A7983_RS14865	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
A7983_RS14870	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
A7983_RS14885	COG2851	Citrate transporter
A7983_RS14890	COG0583	DNA-binding transcription factor activity
A7983_RS14900	COG1876	peptidase activity
A7983_RS14905	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A7983_RS14910	COG1393	Belongs to the ArsC family
A7983_RS14915	COG1794	racemase activity, acting on amino acids and derivatives
A7983_RS14925	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A7983_RS14930	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A7983_RS14935	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A7983_RS14940	COG0321	lipoyl(octanoyl) transferase activity
A7983_RS14945	COG2921	Belongs to the UPF0250 family
A7983_RS14950	COG1686	Belongs to the peptidase S11 family
A7983_RS14960	COG0772	Belongs to the SEDS family
A7983_RS14965	COG0768	penicillin binding
A7983_RS14970	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
A7983_RS14975	COG0799	negative regulation of ribosome biogenesis
A7983_RS14980	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A7983_RS14985	COG1466	dna polymerase III delta subunit
A7983_RS14990	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
A7983_RS14995	COG0495	leucyl-tRNA aminoacylation
A7983_RS15000	COG2888	peptidyl-tyrosine sulfation
A7983_RS15005	COG1126	abc transporter atp-binding protein
A7983_RS15010	COG0765	amino acid transport
A7983_RS15015	COG0765	amino acid transport
A7983_RS15025	COG0815	Transfers the fatty acyl group on membrane lipoproteins
A7983_RS15035	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A7983_RS15040	COG1702	phosphate starvation-inducible protein PhoH
A7983_RS15045	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A7983_RS15050	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A7983_RS15090	COG0367	asparagine synthase
A7983_RS15095	COG1846	Transcriptional regulator
A7983_RS15095	COG1940	carbohydrate kinase activity
A7983_RS15100	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A7983_RS15105	COG0363	glucosamine-6-phosphate deaminase activity
A7983_RS15110	COG2190	(PTS) system
A7983_RS15110	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A7983_RS15110	COG1263	PTS System
A7983_RS15115	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A7983_RS15120	COG0735	belongs to the Fur family
A7983_RS15135	COG0840	transmembrane signaling receptor activity
A7983_RS15145	COG0596	Alpha beta hydrolase
A7983_RS15150	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
A7983_RS15155	COG0033	Phosphoglucomutase
A7983_RS15165	COG0745	RESPONSE REGULATOR receiver
A7983_RS15170	COG2205	protein histidine kinase activity
A7983_RS15175	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
A7983_RS15185	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
A7983_RS15215	COG3272	Protein of unknown function (DUF1722)
A7983_RS15220	COG0415	Belongs to the DNA photolyase family
A7983_RS15225	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A7983_RS15230	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
A7983_RS15235	COG1984	allophanate hydrolase subunit 2
A7983_RS15240	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
A7983_RS15245	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
A7983_RS15250	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A7983_RS15265	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
A7983_RS15270	COG1053	succinate dehydrogenase
A7983_RS15275	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A7983_RS15280	COG0567	Dehydrogenase, E1 component
A7983_RS15285	COG0508	dehydrogenase complex catalyzes the overall conversion of
A7983_RS15290	COG0045	succinate-CoA ligase (ADP-forming) activity
A7983_RS15295	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A7983_RS15305	COG2197	response regulator
A7983_RS15345	COG1271	oxidase subunit
A7983_RS15350	COG1294	oxidase, subunit
A7983_RS15355	COG4890	Cyd operon protein YbgT
A7983_RS15360	COG3790	cyd operon protein YbgE
A7983_RS15365	COG0824	Thioesterase
A7983_RS15370	COG0811	peptide transport
A7983_RS15375	COG0848	biopolymer transport protein
A7983_RS15380	COG3064	Membrane
A7983_RS15385	COG0823	Involved in the tonB-independent uptake of proteins
A7983_RS15390	COG2885	chlorophyll binding
A7983_RS15395	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
A7983_RS15415	COG1811	Na channel or pump
A7983_RS15425	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
A7983_RS15435	COG1230	cation diffusion facilitator family transporter
A7983_RS15440	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A7983_RS15450	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A7983_RS15455	COG0583	DNA-binding transcription factor activity
A7983_RS15460	COG0588	phosphoglycerate mutase activity
A7983_RS15465	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A7983_RS15470	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A7983_RS15490	COG2017	converts alpha-aldose to the beta-anomer
A7983_RS15495	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A7983_RS15500	COG1119	ATPase activity
A7983_RS15505	COG2005	Transcriptional regulator
A7983_RS15505	COG3585	molybdate ion transport
A7983_RS15510	COG0725	ABC transporter, periplasmic molybdate-binding protein
A7983_RS15515	COG4149	molybdate abc transporter
A7983_RS15520	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
A7983_RS15545	COG2211	Major facilitator Superfamily
A7983_RS15550	COG0837	glucose binding
A7983_RS15555	COG0561	phosphatase activity
A7983_RS15570	COG2916	Histone family protein nucleoid-structuring protein H-NS
A7983_RS15580	COG2706	6-phosphogluconolactonase activity
A7983_RS15600	COG2864	formate dehydrogenase
A7983_RS15605	COG0437	4 iron, 4 sulfur cluster binding
A7983_RS15610	COG0243	molybdopterin cofactor binding
A7983_RS15610	COG3383	formate dehydrogenase (NAD+) activity
A7983_RS15615	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A7983_RS15615	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A7983_RS15620	COG0489	protein tyrosine kinase activity
A7983_RS15625	COG0572	uridine kinase
A7983_RS15630	COG0717	Belongs to the dCTP deaminase family
A7983_RS15635	COG2982	Protein involved in outer membrane biogenesis
A7983_RS15640	COG3069	C4-dicarboxylate transmembrane transporter activity
A7983_RS15645	COG1253	flavin adenine dinucleotide binding
A7983_RS15650	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A7983_RS15665	COG0489	protein tyrosine kinase activity
A7983_RS15665	COG3206	protein involved in exopolysaccharide biosynthesis
A7983_RS15690	COG2244	polysaccharide biosynthetic process
A7983_RS15710	COG0438	transferase activity, transferring glycosyl groups
A7983_RS15760	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A7983_RS15765	COG1605	Chorismate mutase
A7983_RS15780	COG3706	GGDEF domain
A7983_RS15795	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A7983_RS15805	COG3962	Belongs to the TPP enzyme family
A7983_RS15810	COG0673	inositol 2-dehydrogenase activity
A7983_RS15825	COG1172	Belongs to the binding-protein-dependent transport system permease family
A7983_RS15835	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A7983_RS15845	COG3718	enzyme involved in inositol metabolism
A7983_RS15860	COG3842	ATPase activity
A7983_RS15865	COG4208	sulfate ABC transporter
A7983_RS15870	COG1840	ABC-type Fe3 transport system, periplasmic component
A7983_RS15895	COG3615	Tellurite resistance protein tehB
A7983_RS15940	COG0401	homolog of Blt101
A7983_RS15945	COG0471	metal ion transport
A7983_RS15955	COG2188	Transcriptional regulator
A7983_RS15970	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A7983_RS15975	COG0303	'Molybdopterin
A7983_RS15980	COG4172	Belongs to the ABC transporter superfamily
A7983_RS15985	COG0747	negative chemotaxis
A7983_RS15990	COG0601	transmembrane transport
A7983_RS15995	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A7983_RS16000	COG0281	malic enzyme
A7983_RS16005	COG0295	cytidine deaminase activity
A7983_RS16015	COG1346	cytolysis
A7983_RS16020	COG1380	Effector of murein hydrolase LrgA
A7983_RS16025	COG5297	Belongs to the glycosyl hydrolase family 6
A7983_RS16035	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A7983_RS16040	COG0156	8-amino-7-oxononanoate synthase activity
A7983_RS16045	COG2226	methyltransferase
A7983_RS16050	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
A7983_RS16065	COG0556	nucleotide-excision repair
A7983_RS16085	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A7983_RS16090	COG0521	Mo-molybdopterin cofactor biosynthetic process
A7983_RS16095	COG0315	cyclic pyranopterin monophosphate synthase activity
A7983_RS16100	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
A7983_RS16105	COG0314	molybdopterin synthase activity
A7983_RS16110	COG0670	Belongs to the BI1 family
A7983_RS16115	COG0842	Transport permease protein
A7983_RS16120	COG0842	Transport permease protein
A7983_RS16125	COG1131	(ABC) transporter
A7983_RS16140	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A7983_RS16145	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A7983_RS16150	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A7983_RS16155	COG1120	ATPase activity
A7983_RS16165	COG0513	Belongs to the DEAD box helicase family
A7983_RS16180	COG2195	Cleaves the N-terminal amino acid of tripeptides
A7983_RS16185	COG0747	negative chemotaxis
A7983_RS16190	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A7983_RS16195	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A7983_RS16200	COG0833	amino acid
A7983_RS16205	COG2040	homocysteine
A7983_RS16230	COG1686	Belongs to the peptidase S11 family
A7983_RS16240	COG1349	DNA-binding transcription factor activity
A7983_RS16245	COG1177	transmembrane transport
A7983_RS16250	COG3842	ATPase activity
A7983_RS16260	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A7983_RS16270	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
A7983_RS16275	COG1280	lysine exporter protein (LysE YggA)
A7983_RS16415	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A7983_RS16425	COG1126	abc transporter atp-binding protein
A7983_RS16430	COG0765	amino acid transport
A7983_RS16435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7983_RS16440	COG0783	Belongs to the Dps family
A7983_RS16445	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A7983_RS16455	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
A7983_RS16460	COG2807	transmembrane transport
A7983_RS16465	COG0534	Mate efflux family protein
A7983_RS16470	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A7983_RS16485	COG3122	Protein conserved in bacteria
A7983_RS16500	COG2801	Transposase and inactivated derivatives
A7983_RS16510	COG0582	viral genome integration into host DNA
A7983_RS16540	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
A7983_RS16580	COG1802	Transcriptional regulator
A7983_RS16580	COG4626	Terminase
A7983_RS16590	COG4725	Belongs to the MT-A70-like family
A7983_RS16600	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
A7983_RS16605	COG1403	HNH endonuclease
A7983_RS16670	COG4626	Terminase
A7983_RS16670	COG1802	Transcriptional regulator
A7983_RS16790	COG3082	Protein of unknown function (DUF1414)
A7983_RS16795	COG3081	Nucleoid-associated protein
A7983_RS16805	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
A7983_RS16810	COG1061	Type III restriction enzyme res subunit
A7983_RS16820	COG1187	pseudouridine synthase activity
A7983_RS16825	COG2814	Major facilitator Superfamily
A7983_RS16835	COG4172	Belongs to the ABC transporter superfamily
A7983_RS16840	COG4239	(ABC) transporter, permease
A7983_RS16845	COG4174	ABC transporter (Permease)
A7983_RS16850	COG4166	transmembrane transport
A7983_RS16855	COG0791	NLP P60 protein
A7983_RS16860	COG0671	phosphoesterase, PA-phosphatase related
A7983_RS16865	COG0523	cobalamin synthesis protein
A7983_RS16870	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A7983_RS16890	COG1105	Belongs to the carbohydrate kinase PfkB family
A7983_RS16895	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A7983_RS16895	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A7983_RS16895	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
A7983_RS16900	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
A7983_RS16905	COG2855	membrane
A7983_RS16910	COG0583	DNA-binding transcription factor activity
A7983_RS16915	COG0833	amino acid
A7983_RS16920	COG4771	TonB-dependent receptor
A7983_RS16925	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A7983_RS16930	COG1172	Belongs to the binding-protein-dependent transport system permease family
A7983_RS16935	COG1129	ABC transporter
A7983_RS16940	COG0371	Dehydrogenase
A7983_RS16965	COG0583	DNA-binding transcription factor activity
A7983_RS16975	COG0840	transmembrane signaling receptor activity
A7983_RS16985	COG0302	gtp cyclohydrolase
A7983_RS16990	COG2311	Membrane
A7983_RS16995	COG2949	membrane
A7983_RS17000	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A7983_RS17015	COG2133	pyrroloquinoline quinone binding
A7983_RS17020	COG0625	glutathione transferase activity
A7983_RS17025	COG1464	Belongs to the NlpA lipoprotein family
A7983_RS17030	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A7983_RS17035	COG2011	ABC-type metal ion transport system permease component
A7983_RS17040	COG1686	Belongs to the peptidase S11 family
A7983_RS17045	COG1349	DNA-binding transcription factor activity
A7983_RS17050	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
A7983_RS17055	COG2985	domain, Protein
A7983_RS17055	COG0569	domain protein
A7983_RS17070	COG0778	Nitroreductase
A7983_RS17075	COG0189	ligase activity
A7983_RS17085	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
A7983_RS17090	COG3842	ATPase activity
A7983_RS17095	COG1176	ABC-type spermidine putrescine transport system, permease component I
A7983_RS17100	COG1177	transmembrane transport
A7983_RS17110	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A7983_RS17115	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7983_RS17120	COG4160	amino acid transport
A7983_RS17125	COG4215	(ABC) transporter
A7983_RS17130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7983_RS17135	COG1126	abc transporter atp-binding protein
A7983_RS17140	COG0393	Putative heavy-metal-binding
A7983_RS17145	COG3023	N-Acetylmuramoyl-L-alanine amidase
A7983_RS17150	COG0702	epimerase
A7983_RS17155	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A7983_RS17160	COG1151	hydroxylamine reductase activity
A7983_RS17165	COG2431	L-lysine efflux transmembrane transporter activity
A7983_RS17170	COG3593	DNA synthesis involved in DNA repair
A7983_RS17175	COG1278	Cold shock
A7983_RS17180	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
A7983_RS17185	COG0542	response to heat
A7983_RS17200	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A7983_RS17205	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
A7983_RS17210	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
A7983_RS17215	COG4988	ABC transporter
A7983_RS17220	COG0492	ferredoxin-NADP+ reductase activity
A7983_RS17230	COG3107	peptidoglycan biosynthetic process
A7983_RS17230	COG1674	ftsk spoiiie
A7983_RS17235	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
A7983_RS17240	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A7983_RS17245	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A7983_RS17250	COG0477	Major facilitator Superfamily
A7983_RS17275	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A7983_RS17280	COG1882	Formate acetyltransferase
A7983_RS17285	COG2116	formate transmembrane transporter activity
A7983_RS17290	COG1944	ATP diphosphatase activity
A7983_RS17295	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
A7983_RS17300	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A7983_RS17305	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A7983_RS17310	COG0539	negative regulation of cytoplasmic translation
A7983_RS17315	COG0776	regulation of translation
A7983_RS17320	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A7983_RS17320	COG0140	phosphoribosyl-ATP diphosphatase activity
A7983_RS17325	COG0107	imidazoleglycerol-phosphate synthase activity
A7983_RS17330	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
A7983_RS17335	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A7983_RS17340	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A7983_RS17340	COG0131	Imidazoleglycerol-phosphate dehydratase
A7983_RS17345	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A7983_RS17350	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A7983_RS17355	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A7983_RS17360	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A7983_RS17365	COG0840	transmembrane signaling receptor activity
A7983_RS17370	COG0840	transmembrane signaling receptor activity
A7983_RS17375	COG4565	transcriptional regulatory protein
A7983_RS17385	COG3493	citrate carrier protein
A7983_RS17390	COG0179	Fumarylacetoacetate (FAA) hydrolase
A7983_RS17395	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
A7983_RS17400	COG3052	prosthetic group binding
A7983_RS17425	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
A7983_RS17435	COG0531	amino acid
A7983_RS17440	COG2925	Exonuclease
A7983_RS17445	COG4607	ABC-type enterochelin transport system periplasmic component
A7983_RS17455	COG4605	iron ion homeostasis
A7983_RS17460	COG4604	ABC transporter, ATP-binding protein
A7983_RS17465	COG2926	Belongs to the UPF0265 family
A7983_RS17475	COG4175	Glycine betaine
A7983_RS17485	COG3119	arylsulfatase activity
A7983_RS17495	COG0658	competence protein
A7983_RS17495	COG2333	competence protein COMEC
A7983_RS17500	COG1132	(ABC) transporter
A7983_RS17505	COG1663	tetraacyldisaccharide 4'-kinase activity
A7983_RS17510	COG2835	tetraacyldisaccharide 4'-kinase activity
A7983_RS17515	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
A7983_RS17525	COG3173	Aminoglycoside phosphotransferase
A7983_RS17530	COG1434	Gram-negative-bacterium-type cell wall biogenesis
A7983_RS17535	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A7983_RS17540	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
A7983_RS17545	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
A7983_RS17550	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
A7983_RS17555	COG2989	Protein conserved in bacteria
A7983_RS17560	COG3108	Peptidase M15
A7983_RS17565	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A7983_RS17570	COG1448	Aminotransferase
A7983_RS17580	COG0017	Asparaginyl-tRNA synthetase
A7983_RS17585	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
A7983_RS17590	COG0308	aminopeptidase N
A7983_RS17595	COG0167	dihydroorotate dehydrogenase activity
A7983_RS17605	COG3217	Mosc domain protein beta barrel domain protein
A7983_RS17605	COG0633	Ferredoxin
A7983_RS17610	COG0116	Belongs to the methyltransferase superfamily
A7983_RS17610	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A7983_RS17615	COG0488	(ABC) transporter
A7983_RS17620	COG2995	paraquat-inducible protein a
A7983_RS17625	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A7983_RS17625	COG3008	intermembrane lipid transfer
A7983_RS17630	COG3009	Protein conserved in bacteria
A7983_RS17635	COG0840	transmembrane signaling receptor activity
A7983_RS17675	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
A7983_RS17680	COG3381	protein complex oligomerization
A7983_RS17690	COG0477	Major facilitator Superfamily
A7983_RS17695	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A7983_RS17700	COG3132	Protein of unknown function, DUF480
A7983_RS17710	COG0728	peptidoglycan biosynthetic process
A7983_RS17715	COG0018	arginyl-trna synthetase
A7983_RS17720	COG3102	Protein conserved in bacteria
A7983_RS17725	COG3142	Participates in the control of copper homeostasis
A7983_RS17730	COG0500	methyltransferase
A7983_RS17735	COG2226	methyltransferase
A7983_RS17740	COG3788	relative of glutathione S-transferase, MAPEG superfamily
A7983_RS17745	COG1801	Protein of unknown function DUF72
A7983_RS17750	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
A7983_RS17755	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A7983_RS17760	COG0494	nUDIX hydrolase
A7983_RS17765	COG0217	transcriptional regulatory protein
A7983_RS17770	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
A7983_RS17775	COG0632	four-way junction helicase activity
A7983_RS17780	COG2255	four-way junction helicase activity
A7983_RS17790	COG1447	Phosphotransferase system cellobiose-specific component IIA
A7983_RS17795	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A7983_RS17805	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A7983_RS17810	COG1121	(ABC) transporter
A7983_RS17815	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
A7983_RS17820	COG0739	heme binding
A7983_RS17825	COG1560	Kdo2-lipid A biosynthetic process
A7983_RS17830	COG0469	pyruvate kinase activity
A7983_RS17835	COG1737	Transcriptional regulator
A7983_RS17840	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A7983_RS17845	COG0800	Aldolase
A7983_RS17850	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
A7983_RS17855	COG1770	oligopeptidase
A7983_RS17865	COG1528	Iron-storage protein
A7983_RS17875	COG4974	Belongs to the 'phage' integrase family
A7983_RS17930	COG5301	cellulose 1,4-beta-cellobiosidase activity
A7983_RS17975	COG3772	lysozyme
A7983_RS18135	COG1278	Cold shock
A7983_RS18145	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
A7983_RS18160	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
A7983_RS18160	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A7983_RS18170	COG2995	paraquat-inducible protein a
A7983_RS18175	COG1956	GAF domain-containing protein
A7983_RS18180	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
A7983_RS18190	COG2207	Transcriptional regulator
A7983_RS18195	COG1881	PFAM PEBP family protein
A7983_RS18205	COG1177	transmembrane transport
A7983_RS18215	COG3842	ATPase activity
A7983_RS18220	COG2195	Cleaves the N-terminal amino acid of tripeptides
A7983_RS18225	COG2850	peptidyl-arginine hydroxylation
A7983_RS18230	COG2205	protein histidine kinase activity
A7983_RS18240	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A7983_RS18245	COG2915	High frequency lysogenization protein hflD homolog
A7983_RS18250	COG0482	sulfurtransferase activity
A7983_RS18260	COG1187	pseudouridine synthase activity
A7983_RS18265	COG0538	isocitrate dehydrogenase activity
A7983_RS18270	COG0348	domain, Protein
A7983_RS18290	COG3300	MHYT domain
A7983_RS18290	COG5001	Diguanylate cyclase
A7983_RS18295	COG3275	phosphorelay sensor kinase activity
A7983_RS18300	COG3279	Response regulator of the LytR AlgR family
A7983_RS18305	COG2223	nitrite transmembrane transporter activity
A7983_RS18320	COG0501	Belongs to the peptidase M48B family
A7983_RS18325	COG0823	Involved in the tonB-independent uptake of proteins
A7983_RS18340	COG1113	amino acid transport
A7983_RS18345	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A7983_RS18350	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A7983_RS18355	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A7983_RS18360	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A7983_RS18365	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A7983_RS18370	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A7983_RS18370	COG0072	phenylalanine-tRNA ligase activity
A7983_RS18375	COG0776	regulation of translation
A7983_RS18390	COG1132	(ABC) transporter
A7983_RS18400	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A7983_RS18405	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A7983_RS18410	COG1823	symporter activity
A7983_RS18415	COG1988	membrane-bound metal-dependent
A7983_RS18420	COG2755	lipolytic protein G-D-S-L family
A7983_RS18420	COG0657	acetylesterase activity
A7983_RS18425	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
A7983_RS18430	COG1653	transport
A7983_RS18435	COG3842	ATPase activity
A7983_RS18440	COG0395	ABC-type sugar transport system, permease component
A7983_RS18445	COG1175	transmembrane transport
A7983_RS18455	COG1028	Short-chain dehydrogenase reductase Sdr
A7983_RS18460	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
A7983_RS18465	COG1917	Cupin 2, conserved barrel domain protein
A7983_RS18470	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A7983_RS18480	COG3001	Fructosamine kinase
A7983_RS18485	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A7983_RS18490	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A7983_RS18495	COG1121	(ABC) transporter
A7983_RS18500	COG0803	Belongs to the bacterial solute-binding protein 9 family
A7983_RS18510	COG2226	methyltransferase
A7983_RS18515	COG1971	Probably functions as a manganese efflux pump
A7983_RS18520	COG4811	Protein of unknown function (DUF986)
A7983_RS18525	COG3716	PTS system mannose fructose sorbose family IID component
A7983_RS18530	COG3715	PTS system
A7983_RS18540	COG1253	flavin adenine dinucleotide binding
A7983_RS18545	COG1760	l-serine dehydratase
A7983_RS18550	COG0494	nUDIX hydrolase
A7983_RS18560	COG3140	Belongs to the UPF0181 family
A7983_RS18565	COG0251	oxidation-reduction process
A7983_RS18570	COG1199	ATP-dependent helicase activity
A7983_RS18580	COG3065	identical protein binding
A7983_RS18585	COG0318	PFAM AMP-dependent synthetase and ligase
A7983_RS18590	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
A7983_RS18595	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
A7983_RS18600	COG2894	cell division
A7983_RS18605	COG0850	regulation of cytokinetic process
A7983_RS18610	COG3100	YcgL domain-containing protein
A7983_RS18615	COG0179	Fumarylacetoacetate (FAA) hydrolase
A7983_RS18620	COG2983	Belongs to the UPF0260 family
A7983_RS18630	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
A7983_RS18635	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A7983_RS18640	COG2186	Transcriptional regulator
A7983_RS18645	COG2719	SpoVR family
A7983_RS18650	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A7983_RS18665	COG2718	Belongs to the UPF0229 family
A7983_RS18670	COG2766	serine protein kinase
A7983_RS18675	COG3713	MltA-interacting MipA family protein
A7983_RS18680	COG0656	L-ascorbic acid biosynthetic process
A7983_RS18695	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A7983_RS18700	COG3139	Protein of unknown function (DUF1315)
A7983_RS18705	COG1335	isochorismatase
A7983_RS18710	COG0252	asparaginase activity
A7983_RS18715	COG0616	signal peptide processing
A7983_RS18720	COG0778	Nitroreductase
A7983_RS18725	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A7983_RS18735	COG0708	Exodeoxyribonuclease III
A7983_RS18740	COG2860	membrane
A7983_RS18760	COG0788	formyltetrahydrofolate deformylase activity
A7983_RS18765	COG1752	Esterase of the alpha-beta hydrolase superfamily
A7983_RS18770	COG0745	RESPONSE REGULATOR receiver
A7983_RS18775	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A7983_RS18785	COG1435	thymidine kinase activity
A7983_RS18790	COG1012	belongs to the aldehyde dehydrogenase family
A7983_RS18790	COG1454	alcohol dehydrogenase
A7983_RS18805	COG0601	transmembrane transport
A7983_RS18810	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A7983_RS18815	COG0444	Belongs to the ABC transporter superfamily
A7983_RS18825	COG3099	Belongs to the UPF0263 family
A7983_RS18830	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A7983_RS18840	COG2350	Protein conserved in bacteria
A7983_RS18850	COG1607	acyl-coa hydrolase
A7983_RS18855	COG2917	probably involved in intracellular septation
A7983_RS18865	COG3047	cAMP biosynthetic process
A7983_RS18870	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
A7983_RS18875	COG0159	tryptophan synthase activity
A7983_RS18880	COG0133	tryptophan synthase activity
A7983_RS18885	COG0135	phosphoribosylanthranilate isomerase activity
A7983_RS18885	COG0134	indole-3-glycerol-phosphate synthase activity
A7983_RS18890	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A7983_RS18895	COG0512	Glutamine amidotransferase of anthranilate synthase
A7983_RS18910	COG0009	L-threonylcarbamoyladenylate synthase
A7983_RS18915	COG1187	pseudouridine synthase activity
A7983_RS18920	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
A7983_RS18925	COG1028	Short-chain dehydrogenase reductase Sdr
A7983_RS18930	COG0616	signal peptide processing
A7983_RS18950	COG3104	oligopeptide transport
A7983_RS18955	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A7983_RS18965	COG4659	FMN binding
A7983_RS18970	COG4658	electron transport chain
A7983_RS18975	COG4656	Part of a membrane complex involved in electron transport
A7983_RS18980	COG2878	Part of a membrane complex involved in electron transport
A7983_RS18985	COG4657	Part of a membrane complex involved in electron transport
A7983_RS18995	COG2160	L-arabinose isomerase activity
A7983_RS19000	COG1069	ribulokinase activity
A7983_RS19005	COG1879	ABC-type sugar transport system periplasmic component
A7983_RS19010	COG1129	ABC transporter
A7983_RS19015	COG1172	Belongs to the binding-protein-dependent transport system permease family
A7983_RS19025	COG0673	inositol 2-dehydrogenase activity
A7983_RS19030	COG0385	Bile acid
A7983_RS19045	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A7983_RS19055	COG5339	Protein conserved in bacteria
A7983_RS19060	COG1482	cell wall glycoprotein biosynthetic process
A7983_RS19065	COG0114	fumarate hydratase activity
A7983_RS19080	COG0583	DNA-binding transcription factor activity
A7983_RS19085	COG1940	carbohydrate kinase activity
A7983_RS19095	COG0477	Major facilitator Superfamily
A7983_RS19115	COG4221	oxidoreductase activity
A7983_RS19120	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A7983_RS19130	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
A7983_RS19135	COG1942	4-Oxalocrotonate Tautomerase
A7983_RS19140	COG0076	glutamate decarboxylase activity
A7983_RS19145	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A7983_RS19150	COG1649	PFAM Uncharacterised BCR, COG1649
A7983_RS19155	COG4628	conserved protein (DUF2132)
A7983_RS19180	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A7983_RS19185	COG2267	carboxylic ester hydrolase activity
A7983_RS19190	COG0671	phosphoesterase, PA-phosphatase related
A7983_RS19190	COG2453	phosphatase
A7983_RS19265	COG0251	oxidation-reduction process
A7983_RS19285	COG0456	acetyltransferase
A7983_RS19290	COG0738	Major facilitator superfamily
A7983_RS19300	COG3783	Cytochrome b(562)
A7983_RS19305	COG4305	rare lipoprotein A
A7983_RS19340	COG0673	inositol 2-dehydrogenase activity
A7983_RS19345	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A7983_RS19350	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A7983_RS19360	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
A7983_RS19365	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
A7983_RS19375	COG2877	3-deoxy-8-phosphooctulonate synthase activity
A7983_RS19380	COG2912	Transglutaminase-like superfamily
A7983_RS19390	COG2890	protein-(glutamine-N5) methyltransferase activity
A7983_RS19395	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A7983_RS19400	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
A7983_RS19405	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
A7983_RS19410	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
A7983_RS19415	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A7983_RS19425	COG0193	aminoacyl-tRNA hydrolase activity
A7983_RS19430	COG0012	GTP binding
A7983_RS19445	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A7983_RS19450	COG0326	Molecular chaperone. Has ATPase activity
A7983_RS19470	COG2169	Transcriptional regulator
A7983_RS19475	COG1757	Na H antiporter
A7983_RS19480	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
A7983_RS19485	COG4676	Protein conserved in bacteria
A7983_RS19490	COG5445	Predicted secreted protein (DUF2300)
A7983_RS19505	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
A7983_RS19610	COG0515	serine threonine protein kinase
A7983_RS19710	COG2755	lipolytic protein G-D-S-L family
A7983_RS19745	COG0346	lactoylglutathione lyase activity
A7983_RS19750	COG0483	inositol monophosphate 1-phosphatase activity
A7983_RS19755	COG2723	6-phospho-beta-galactosidase activity
A7983_RS19760	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A7983_RS19760	COG1263	PTS System
A7983_RS19765	COG1609	Transcriptional regulator
A7983_RS19775	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A7983_RS19780	COG1473	amidohydrolase
A7983_RS19790	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A7983_RS19795	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
A7983_RS19800	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7983_RS19810	COG0765	amino acid transport
A7983_RS19815	COG1126	abc transporter atp-binding protein
A7983_RS19820	COG2314	TM2 domain
A7983_RS19830	COG1129	ABC transporter
A7983_RS19845	COG0683	leucine binding
A7983_RS19850	COG1802	Transcriptional regulator
A7983_RS19930	COG2801	Transposase and inactivated derivatives
A7983_RS19935	COG2801	Transposase and inactivated derivatives
A7983_RS19940	COG2963	transposase activity
A7983_RS19950	COG2963	transposase activity
A7983_RS19985	COG1802	Transcriptional regulator
A7983_RS19995	COG4943	cyclic-guanylate-specific phosphodiesterase activity
A7983_RS20000	COG0583	DNA-binding transcription factor activity
A7983_RS20015	COG1464	Belongs to the NlpA lipoprotein family
A7983_RS20020	COG4948	Mandelate Racemase Muconate Lactonizing
A7983_RS20025	COG2011	ABC-type metal ion transport system permease component
A7983_RS20030	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A7983_RS20035	COG0546	phosphoglycolate phosphatase activity
A7983_RS20040	COG0671	phosphoesterase, PA-phosphatase related
A7983_RS20050	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A7983_RS20060	COG1028	Short-chain dehydrogenase reductase Sdr
A7983_RS20070	COG1176	ABC-type spermidine putrescine transport system, permease component I
A7983_RS20080	COG1012	belongs to the aldehyde dehydrogenase family
A7983_RS20085	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A7983_RS20095	COG3842	ATPase activity
A7983_RS20100	COG2261	transglycosylase associated protein
A7983_RS20120	COG2801	Transposase and inactivated derivatives
A7983_RS20125	COG2963	transposase activity
A7983_RS20160	COG1846	Transcriptional regulator
A7983_RS20165	COG0697	spore germination
A7983_RS20170	COG2181	nitrate reductase activity
A7983_RS20175	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
A7983_RS20180	COG1140	nitrate reductase beta subunit
A7983_RS20185	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
A7983_RS20190	COG2223	nitrite transmembrane transporter activity
A7983_RS20195	COG3850	Histidine kinase
A7983_RS20200	COG2197	response regulator
A7983_RS20215	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
A7983_RS20225	COG0387	Pfam Sodium calcium exchanger
A7983_RS20230	COG0659	secondary active sulfate transmembrane transporter activity
A7983_RS20235	COG1028	Short-chain dehydrogenase reductase Sdr
A7983_RS20260	COG0745	RESPONSE REGULATOR receiver
A7983_RS20265	COG2205	protein histidine kinase activity
A7983_RS20300	COG3539	Fimbrial protein
A7983_RS20305	COG3591	Belongs to the peptidase S1B family
A7983_RS20310	COG3300	MHYT domain
A7983_RS20310	COG5001	Diguanylate cyclase
A7983_RS20315	COG1643	Atp-dependent helicase
A7983_RS20320	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A7983_RS20330	COG2911	Protein conserved in bacteria
A7983_RS20335	COG0840	transmembrane signaling receptor activity
A7983_RS20340	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A7983_RS20355	COG0037	tRNA processing
A7983_RS20365	COG0598	Magnesium transport protein CorA
A7983_RS20370	COG4166	transmembrane transport
A7983_RS20375	COG2866	Carboxypeptidase
A7983_RS20380	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
A7983_RS20395	COG3768	UPF0283 membrane protein
A7983_RS20400	COG3106	COG3106 Predicted ATPase
A7983_RS20405	COG1983	PspC domain protein
A7983_RS20415	COG1842	Phage shock protein A
A7983_RS20420	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
A7983_RS20430	COG1028	Short-chain dehydrogenase reductase Sdr
A7983_RS20435	COG0583	DNA-binding transcription factor activity
A7983_RS20440	COG4166	transmembrane transport
A7983_RS20450	COG4171	peptide transport system, permease
A7983_RS20470	COG2249	NAD(P)H dehydrogenase (quinone) activity
A7983_RS20475	COG1733	regulation of RNA biosynthetic process
A7983_RS20510	COG1053	succinate dehydrogenase
A7983_RS20520	COG2271	Major facilitator Superfamily
A7983_RS20525	COG1609	Transcriptional regulator
A7983_RS20530	COG0583	DNA-binding transcription factor activity
A7983_RS20535	COG0243	molybdopterin cofactor binding
A7983_RS20540	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
A7983_RS20545	COG4989	oxidoreductase activity
A7983_RS20550	COG1966	Carbon starvation protein
A7983_RS20555	COG0235	Class ii aldolase
A7983_RS20565	COG0023	Translation Initiation Factor
A7983_RS20570	COG0284	orotidine-5'-phosphate decarboxylase activity
A7983_RS20575	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
A7983_RS20580	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
A7983_RS20590	COG1082	Xylose isomerase domain protein TIM barrel
A7983_RS20595	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A7983_RS20600	COG3958	Transketolase
A7983_RS20605	COG3959	Transketolase, thiamine diphosphate binding domain
A7983_RS20610	COG1172	Belongs to the binding-protein-dependent transport system permease family
A7983_RS20615	COG1129	ABC transporter
A7983_RS20625	COG1879	ABC-type sugar transport system periplasmic component
A7983_RS20640	COG0671	phosphoesterase, PA-phosphatase related
A7983_RS20645	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A7983_RS20660	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A7983_RS20670	COG1301	dicarboxylic acid transport
A7983_RS20675	COG0625	glutathione transferase activity
A7983_RS20680	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
A7983_RS20685	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A7983_RS20690	COG0259	pyridoxamine-phosphate oxidase activity
A7983_RS20695	COG3895	Periplasmic Protein
A7983_RS20700	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
A7983_RS20710	COG1846	Transcriptional regulator
A7983_RS20715	COG0346	lactoylglutathione lyase activity
A7983_RS20720	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A7983_RS20725	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
A7983_RS20730	COG0791	NLP P60 protein
A7983_RS20735	COG1609	Transcriptional regulator
A7983_RS20740	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A7983_RS20745	COG0307	riboflavin synthase, alpha
A7983_RS20750	COG0534	Mate efflux family protein
A7983_RS20760	COG1620	l-lactate permease
A7983_RS20765	COG0247	lactate metabolic process
A7983_RS20770	COG1139	Iron-sulfur cluster binding protein
A7983_RS20775	COG1556	Lactate utilization protein
A7983_RS20790	COG3665	Urea carboxylase-associated protein
A7983_RS20795	COG3842	ATPase activity
A7983_RS20820	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
A7983_RS20825	COG1408	metallophosphoesterase
A7983_RS20835	COG0561	phosphatase activity
A7983_RS20850	COG0582	viral genome integration into host DNA
A7983_RS20895	COG0629	single-stranded DNA binding
A7983_RS20900	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A7983_RS20905	COG0270	DNA (cytosine-5-)-methyltransferase activity
A7983_RS20960	COG0210	DNA helicase
A7983_RS21015	COG0583	DNA-binding transcription factor activity
A7983_RS21065	COG2003	Belongs to the UPF0758 family
A7983_RS21115	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A7983_RS21125	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
A7983_RS21145	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A7983_RS21150	COG4977	sequence-specific DNA binding
A7983_RS21160	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
A7983_RS21165	COG1335	isochorismatase
A7983_RS21180	COG1764	response to oxidative stress
A7983_RS21185	COG4580	involved in the transport of maltose and maltodextrins
A7983_RS21195	COG0641	radical SAM
A7983_RS21210	COG4533	DNA binding
A7983_RS21215	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
A7983_RS21265	COG3209	COG3209 Rhs family protein
A7983_RS21265	COG4104	PAAR repeat-containing protein
A7983_RS21275	COG3501	Rhs element vgr protein
A7983_RS21285	COG3423	Transcriptional regulator
A7983_RS21310	COG2197	response regulator
A7983_RS21315	COG3850	Histidine kinase
A7983_RS21320	COG3062	negative regulation of establishment of protein localization
A7983_RS21325	COG0243	molybdopterin cofactor binding
A7983_RS21330	COG0437	4 iron, 4 sulfur cluster binding
A7983_RS21335	COG0348	domain, Protein
A7983_RS21340	COG3043	anaerobic respiration
A7983_RS21345	COG3005	denitrification pathway
A7983_RS21355	COG3088	subunit of a heme lyase
A7983_RS21355	COG4235	cytochrome complex assembly
A7983_RS21360	COG3088	subunit of a heme lyase
A7983_RS21360	COG4235	cytochrome complex assembly
A7983_RS21365	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A7983_RS21370	COG1138	Cytochrome C-type biogenesis protein
A7983_RS21375	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
A7983_RS21380	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A7983_RS21385	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A7983_RS21390	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A7983_RS21395	COG4133	protoheme IX ABC transporter activity
A7983_RS21400	COG4235	cytochrome complex assembly
A7983_RS21405	COG3088	subunit of a heme lyase
A7983_RS21410	COG1138	Cytochrome C-type biogenesis protein
A7983_RS21420	COG0437	4 iron, 4 sulfur cluster binding
A7983_RS21425	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
A7983_RS21430	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
A7983_RS21440	COG2382	esterase
A7983_RS21480	COG4238	major outer membrane lipoprotein
A7983_RS21485	COG1388	LysM domain
A7983_RS21485	COG1376	ErfK ybiS ycfS ynhG family protein
A7983_RS21490	COG2166	iron-sulfur cluster assembly
A7983_RS21495	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A7983_RS21500	COG0719	Fe-S assembly protein
A7983_RS21505	COG0396	ATPase activity
A7983_RS21510	COG0719	Fe-S assembly protein
A7983_RS21515	COG0316	Belongs to the HesB IscA family
A7983_RS21525	COG2050	protein possibly involved in aromatic compounds catabolism
A7983_RS21530	COG0277	FAD linked oxidase domain protein
A7983_RS21530	COG0247	lactate metabolic process
A7983_RS21535	COG0628	permease
A7983_RS21545	COG1477	protein flavinylation
A7983_RS21550	COG0574	Belongs to the PEP-utilizing enzyme family
A7983_RS21550	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A7983_RS21555	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
A7983_RS21560	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A7983_RS21565	COG3720	iron ion transport
A7983_RS21570	COG4558	Periplasmic binding protein
A7983_RS21575	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A7983_RS21580	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
A7983_RS21585	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
A7983_RS21600	COG3265	gluconokinase activity
A7983_RS21605	COG1609	Transcriptional regulator
A7983_RS21610	COG0129	dihydroxy-acid dehydratase activity
A7983_RS21615	COG0791	NLP P60 protein
A7983_RS21620	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
A7983_RS21625	COG0386	Belongs to the glutathione peroxidase family
A7983_RS21630	COG4139	cobalamin transport
A7983_RS21635	COG2226	methyltransferase
A7983_RS21655	COG1940	carbohydrate kinase activity
A7983_RS21660	COG4591	ABC-type transport system involved in lipoprotein release permease component
A7983_RS21665	COG1136	(ABC) transporter
A7983_RS21670	COG4591	ABC-type transport system involved in lipoprotein release permease component
A7983_RS21675	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A7983_RS21680	COG0443	Heat shock 70 kDa protein
A7983_RS21685	COG1309	transcriptional regulator
A7983_RS21700	COG3134	Outer membrane lipoprotein
A7983_RS21705	COG1252	NADH dehydrogenase
A7983_RS21710	COG3150	esterase
A7983_RS21715	COG1472	Belongs to the glycosyl hydrolase 3 family
A7983_RS21725	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
A7983_RS21735	COG0537	adenosine 5'-monophosphoramidase activity
A7983_RS21740	COG1263	PTS System
A7983_RS21740	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A7983_RS21745	COG0084	hydrolase, TatD family'
A7983_RS21750	COG0470	DNA polymerase III
A7983_RS21755	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A7983_RS21760	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A7983_RS21765	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A7983_RS21770	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A7983_RS21775	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A7983_RS21785	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A7983_RS21790	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A7983_RS21795	COG0416	fatty acid biosynthetic process
A7983_RS21800	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A7983_RS21805	COG1399	metal-binding, possibly nucleic acid-binding protein
A7983_RS21810	COG0424	maF-like protein
A7983_RS21815	COG0564	pseudouridine synthase activity
A7983_RS21820	COG1530	ribonuclease E activity
A7983_RS21830	COG0418	dihydroorotase activity
A7983_RS21850	COG3038	cytochrome b561
A7983_RS21855	COG2353	YceI-like domain
A7983_RS21860	COG1054	Belongs to the UPF0176 family
A7983_RS21865	COG1902	pentaerythritol trinitrate reductase activity
A7983_RS21870	COG1560	Kdo2-lipid A biosynthetic process
A7983_RS21875	COG2943	transferase activity, transferring hexosyl groups
A7983_RS21880	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
A7983_RS21890	COG0840	transmembrane signaling receptor activity
A7983_RS21905	COG1683	Conserved Protein
A7983_RS21910	COG0589	response to stress
A7983_RS21935	COG0670	Belongs to the BI1 family
A7983_RS21940	COG2920	part of a sulfur-relay system
A7983_RS21945	COG1254	Belongs to the acylphosphatase family
A7983_RS21950	COG3785	DNA binding
A7983_RS21955	COG1832	CoA-binding protein
A7983_RS21965	COG1803	Methylglyoxal synthase
A7983_RS21970	COG0210	DNA helicase
A7983_RS21975	COG3304	Inner membrane component domain
A7983_RS21980	COG1289	transmembrane transporter activity
A7983_RS21985	COG3070	regulator of competence-specific genes
A7983_RS21990	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
A7983_RS22005	COG1067	ATP-dependent peptidase activity
A7983_RS22010	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A7983_RS22015	COG2979	Protein of unknown function (DUF533)
A7983_RS22045	COG1702	phosphate starvation-inducible protein PhoH
A7983_RS22055	COG1191	sigma factor activity
A7983_RS22060	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A7983_RS22060	COG4797	methyltransferase
A7983_RS22065	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A7983_RS22085	COG1677	Flagellar hook-basal body complex protein FliE
A7983_RS22090	COG1766	The M ring may be actively involved in energy transduction
A7983_RS22095	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A7983_RS22100	COG1317	bacterial-type flagellum organization
A7983_RS22120	COG1580	Controls the rotational direction of flagella during chemotaxis
A7983_RS22155	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A7983_RS22170	COG1706	bacterial-type flagellum-dependent cell motility
A7983_RS22175	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
A7983_RS22185	COG4787	bacterial-type flagellum-dependent cell motility
A7983_RS22190	COG1749	Flagellar hook protein flgE
A7983_RS22195	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
A7983_RS22200	COG1558	bacterial-type flagellum-dependent cell motility
A7983_RS22205	COG1815	bacterial-type flagellum-dependent cell motility
A7983_RS22215	COG2747	anti-sigma28 factor FlgM
A7983_RS22220	COG3418	PFAM FlgN family protein
A7983_RS22230	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A7983_RS22235	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A7983_RS22245	COG0745	RESPONSE REGULATOR receiver
A7983_RS22250	COG2201	protein-glutamate methylesterase activity
A7983_RS22255	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
A7983_RS22260	COG0840	transmembrane signaling receptor activity
A7983_RS22265	COG0835	chemotaxis
A7983_RS22270	COG2198	Histidine kinase
A7983_RS22270	COG0643	Histidine kinase
A7983_RS22300	COG0840	transmembrane signaling receptor activity
A7983_RS22310	COG3706	GGDEF domain
A7983_RS22315	COG0640	Transcriptional regulator
A7983_RS22320	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A7983_RS22325	COG1733	regulation of RNA biosynthetic process
A7983_RS22330	COG2910	NAD(P)H-binding
A7983_RS22335	COG0625	glutathione transferase activity
A7983_RS22340	COG2814	Major facilitator Superfamily
A7983_RS22345	COG3226	Transcriptional regulator
A7983_RS22355	COG0784	Response regulator, receiver
A7983_RS22355	COG0835	chemotaxis
A7983_RS22370	COG2995	paraquat-inducible protein a
A7983_RS22375	COG3008	intermembrane lipid transfer
A7983_RS22375	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A7983_RS22410	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A7983_RS22425	COG4172	Belongs to the ABC transporter superfamily
A7983_RS22440	COG0747	negative chemotaxis
A7983_RS22445	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A7983_RS22450	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A7983_RS22460	COG2226	methyltransferase
A7983_RS22465	COG0840	transmembrane signaling receptor activity
A7983_RS22470	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A7983_RS22475	COG1012	belongs to the aldehyde dehydrogenase family
A7983_RS22500	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
A7983_RS22510	COG2515	1-aminocyclopropane-1-carboxylate deaminase
A7983_RS22520	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A7983_RS22530	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
A7983_RS22540	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
A7983_RS22545	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A7983_RS22550	COG0371	Dehydrogenase
A7983_RS22555	COG1301	dicarboxylic acid transport
A7983_RS22570	COG0697	spore germination
A7983_RS22575	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A7983_RS22580	COG1136	(ABC) transporter
A7983_RS22580	COG0577	efflux transmembrane transporter activity
A7983_RS22590	COG1136	(ABC) transporter
A7983_RS22590	COG0577	efflux transmembrane transporter activity
A7983_RS22605	COG0672	)-iron permease
A7983_RS22615	COG3383	formate dehydrogenase (NAD+) activity
A7983_RS22620	COG1301	dicarboxylic acid transport
A7983_RS22625	COG0583	DNA-binding transcription factor activity
A7983_RS22640	COG1464	Belongs to the NlpA lipoprotein family
A7983_RS22655	COG2271	Major facilitator Superfamily
A7983_RS22660	COG1840	ABC-type Fe3 transport system, periplasmic component
A7983_RS22670	COG3842	ATPase activity
A7983_RS22695	COG0582	viral genome integration into host DNA
A7983_RS22715	COG0745	RESPONSE REGULATOR receiver
A7983_RS22785	COG3736	Type IV secretory pathway, component VirB8
A7983_RS22790	COG3504	Conjugal transfer protein
A7983_RS22800	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
A7983_RS22835	COG4227	nucleotidyltransferase activity
A7983_RS22885	COG2801	Transposase and inactivated derivatives
A7983_RS22900	COG3228	Belongs to the MtfA family
A7983_RS22910	COG0582	viral genome integration into host DNA