locus-tag	class	description
CPU05_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CPU05_RS00010	COG0592	DNA-directed DNA polymerase activity
CPU05_RS00015	COG2501	S4 domain
CPU05_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CPU05_RS00025	COG0187	DNA topoisomerase II activity
CPU05_RS00035	COG0360	Binds together with S18 to 16S ribosomal RNA
CPU05_RS00040	COG0629	single-stranded DNA binding
CPU05_RS00045	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CPU05_RS00055	COG0359	binds to the 23S rRNA
CPU05_RS00060	COG0305	Participates in initiation and elongation during chromosome replication
CPU05_RS00065	COG2814	Major facilitator Superfamily
CPU05_RS00080	COG0488	(ABC) transporter
CPU05_RS00095	COG1136	(ABC) transporter
CPU05_RS00105	COG1396	sequence-specific DNA binding
CPU05_RS00110	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CPU05_RS00120	COG0431	NADPH-dependent FMN reductase
CPU05_RS00130	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CPU05_RS00140	COG2235	arginine
CPU05_RS00170	COG0789	Transcriptional regulator
CPU05_RS00175	COG2076	Multidrug Resistance protein
CPU05_RS00185	COG1272	protein, Hemolysin III
CPU05_RS00270	COG0110	maltose O-acetyltransferase activity
CPU05_RS00275	COG4221	oxidoreductase activity
CPU05_RS00300	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CPU05_RS00340	COG0656	L-ascorbic acid biosynthetic process
CPU05_RS00395	COG1215	transferase activity, transferring glycosyl groups
CPU05_RS00400	COG2723	6-phospho-beta-galactosidase activity
CPU05_RS00425	COG0667	Aldo Keto reductase
CPU05_RS00430	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CPU05_RS00440	COG3546	catalase activity
CPU05_RS00485	COG4932	domain protein
CPU05_RS00495	COG3775	system Galactitol-specific IIC component
CPU05_RS00510	COG1349	DNA-binding transcription factor activity
CPU05_RS00525	COG3684	Belongs to the aldolase LacD family
CPU05_RS00540	COG1737	Transcriptional regulator
CPU05_RS00550	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CPU05_RS00550	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CPU05_RS00550	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CPU05_RS00555	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
CPU05_RS00565	COG1028	Short-chain dehydrogenase reductase Sdr
CPU05_RS00585	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CPU05_RS00595	COG1737	Transcriptional regulator
CPU05_RS00600	COG1285	pathogenesis
CPU05_RS00605	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CPU05_RS00610	COG3715	PTS system
CPU05_RS00615	COG3716	PTS system mannose fructose sorbose family IID component
CPU05_RS00655	COG0028	Belongs to the TPP enzyme family
CPU05_RS00715	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CPU05_RS00720	COG0531	amino acid
CPU05_RS00725	COG2957	Belongs to the agmatine deiminase family
CPU05_RS00745	COG2207	Transcriptional regulator
CPU05_RS00745	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CPU05_RS00755	COG0656	L-ascorbic acid biosynthetic process
CPU05_RS00775	COG3715	PTS system
CPU05_RS00780	COG3716	PTS system mannose fructose sorbose family IID component
CPU05_RS00785	COG2222	sugar isomerase
CPU05_RS00800	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CPU05_RS00805	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CPU05_RS00810	COG0813	purine-nucleoside phosphorylase activity
CPU05_RS00815	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CPU05_RS00825	COG2390	Transcriptional regulator
CPU05_RS00845	COG3940	Belongs to the glycosyl hydrolase 43 family
CPU05_RS00860	COG1442	glycosyl transferase family 8
CPU05_RS00875	COG1929	Belongs to the glycerate kinase type-1 family
CPU05_RS00880	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CPU05_RS00885	COG0697	spore germination
CPU05_RS00890	COG0438	transferase activity, transferring glycosyl groups
CPU05_RS00895	COG0438	transferase activity, transferring glycosyl groups
CPU05_RS00900	COG0778	Nitroreductase
CPU05_RS00910	COG1733	regulation of RNA biosynthetic process
CPU05_RS00915	COG0604	alcohol dehydrogenase
CPU05_RS00920	COG0351	phosphomethylpyrimidine kinase
CPU05_RS00935	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CPU05_RS00955	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CPU05_RS00960	COG2814	Major facilitator Superfamily
CPU05_RS00990	COG0402	S-adenosylhomocysteine deaminase activity
CPU05_RS01015	COG3973	AAA domain
CPU05_RS01050	COG1801	Protein of unknown function DUF72
CPU05_RS01055	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CPU05_RS01055	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CPU05_RS01060	COG0084	hydrolase, TatD family'
CPU05_RS01070	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CPU05_RS01075	COG4466	Protein conserved in bacteria
CPU05_RS01080	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CPU05_RS01090	COG0589	response to stress
CPU05_RS01100	COG0477	Major facilitator Superfamily
CPU05_RS01110	COG3842	ATPase activity
CPU05_RS01115	COG4120	Belongs to the binding-protein-dependent transport system permease family
CPU05_RS01125	COG2188	Transcriptional regulator
CPU05_RS01130	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CPU05_RS01135	COG1447	Phosphotransferase system cellobiose-specific component IIA
CPU05_RS01140	COG2723	6-phospho-beta-galactosidase activity
CPU05_RS01150	COG0446	pyridine nucleotide-disulphide oxidoreductase
CPU05_RS01170	COG1288	antiporter activity
CPU05_RS01175	COG1573	uracil-dna glycosylase
CPU05_RS01180	COG0803	Belongs to the bacterial solute-binding protein 9 family
CPU05_RS01185	COG1121	(ABC) transporter
CPU05_RS01190	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CPU05_RS01195	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CPU05_RS01200	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CPU05_RS01210	COG0577	efflux transmembrane transporter activity
CPU05_RS01215	COG1136	(ABC) transporter
CPU05_RS01280	COG4869	propanediol catabolic process
CPU05_RS01290	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
CPU05_RS01305	COG1012	belongs to the aldehyde dehydrogenase family
CPU05_RS01315	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CPU05_RS01325	COG1902	pentaerythritol trinitrate reductase activity
CPU05_RS01330	COG2365	Tyrosine phosphatase family
CPU05_RS01335	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CPU05_RS01360	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CPU05_RS01365	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CPU05_RS01385	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CPU05_RS01390	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CPU05_RS01400	COG3590	peptidase
CPU05_RS01405	COG2502	aspartate--ammonia ligase
CPU05_RS01410	COG2252	PERMEase
CPU05_RS01415	COG0328	RNA-DNA hybrid ribonuclease activity
CPU05_RS01420	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
CPU05_RS01435	COG1215	transferase activity, transferring glycosyl groups
CPU05_RS01465	COG2855	membrane
CPU05_RS01480	COG0561	phosphatase activity
CPU05_RS01485	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CPU05_RS01490	COG0540	Belongs to the ATCase OTCase family
CPU05_RS01495	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CPU05_RS01500	COG0505	Belongs to the CarA family
CPU05_RS01505	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CPU05_RS01510	COG0167	dihydroorotate dehydrogenase activity
CPU05_RS01515	COG1053	succinate dehydrogenase
CPU05_RS01525	COG2814	Major facilitator Superfamily
CPU05_RS01530	COG0346	lactoylglutathione lyase activity
CPU05_RS01545	COG0363	glucosamine-6-phosphate deaminase activity
CPU05_RS01550	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CPU05_RS01555	COG0280	phosphate acetyltransferase
CPU05_RS01560	COG0735	belongs to the Fur family
CPU05_RS01565	COG2814	Major facilitator Superfamily
CPU05_RS01570	COG1295	ribonuclease BN
CPU05_RS01580	COG2365	Tyrosine phosphatase family
CPU05_RS01585	COG2365	Tyrosine phosphatase family
CPU05_RS01590	COG1780	Probably involved in ribonucleotide reductase function
CPU05_RS01595	COG0561	phosphatase activity
CPU05_RS01600	COG1131	(ABC) transporter
CPU05_RS01605	COG3559	Exporter of polyketide antibiotics
CPU05_RS01610	COG1253	flavin adenine dinucleotide binding
CPU05_RS01615	COG4989	oxidoreductase activity
CPU05_RS01630	COG1737	Transcriptional regulator
CPU05_RS01635	COG1263	PTS System
CPU05_RS01635	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CPU05_RS01640	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CPU05_RS01645	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CPU05_RS01650	COG2188	Transcriptional regulator
CPU05_RS01655	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
CPU05_RS01660	COG1051	belongs to the nudix hydrolase family
CPU05_RS01665	COG0564	pseudouridine synthase activity
CPU05_RS01675	COG1940	carbohydrate kinase activity
CPU05_RS01680	COG1811	Na channel or pump
CPU05_RS01685	COG0583	DNA-binding transcription factor activity
CPU05_RS01690	COG2084	Dehydrogenase
CPU05_RS01700	COG1376	ErfK ybiS ycfS ynhG family protein
CPU05_RS01710	COG0586	Pfam SNARE associated Golgi protein
CPU05_RS01730	COG0025	NhaP-type Na H and K H
CPU05_RS01740	COG0492	ferredoxin-NADP+ reductase activity
CPU05_RS01745	COG1368	sulfuric ester hydrolase activity
CPU05_RS01775	COG3118	belongs to the thioredoxin family
CPU05_RS01795	COG0488	(ABC) transporter
CPU05_RS01800	COG0656	L-ascorbic acid biosynthetic process
CPU05_RS01805	COG2267	carboxylic ester hydrolase activity
CPU05_RS01815	COG2936	dipeptidyl-peptidase activity
CPU05_RS01820	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CPU05_RS01825	COG2252	PERMEase
CPU05_RS01830	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CPU05_RS01850	COG0194	GDP metabolic process
CPU05_RS01855	COG0735	belongs to the Fur family
CPU05_RS01875	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CPU05_RS01880	COG0765	amino acid transport
CPU05_RS01885	COG0765	amino acid transport
CPU05_RS01890	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CPU05_RS01900	COG0531	amino acid
CPU05_RS01905	COG0588	phosphoglycerate mutase activity
CPU05_RS01910	COG3973	AAA domain
CPU05_RS01915	COG0028	Belongs to the TPP enzyme family
CPU05_RS01920	COG3527	Alpha-acetolactate decarboxylase
CPU05_RS01925	COG1072	(Pantothenic acid kinase))
CPU05_RS01935	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CPU05_RS01940	COG2217	Heavy metal translocating P-type atpase
CPU05_RS01955	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CPU05_RS01955	COG0519	Catalyzes the synthesis of GMP from XMP
CPU05_RS01980	COG0477	Major facilitator Superfamily
CPU05_RS01985	COG0308	aminopeptidase N
CPU05_RS01995	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
CPU05_RS02000	COG1518	maintenance of DNA repeat elements
CPU05_RS02020	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CPU05_RS02025	COG0459	protein refolding
CPU05_RS02030	COG0531	amino acid
CPU05_RS02035	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CPU05_RS02040	COG1739	Uncharacterized protein family UPF0029
CPU05_RS02045	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
CPU05_RS02060	COG0653	protein targeting
CPU05_RS02070	COG0745	RESPONSE REGULATOR receiver
CPU05_RS02075	COG5002	protein histidine kinase activity
CPU05_RS02085	COG0573	inorganic phosphate transmembrane transporter activity
CPU05_RS02090	COG0581	inorganic phosphate transmembrane transporter activity
CPU05_RS02100	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CPU05_RS02105	COG0704	Plays a role in the regulation of phosphate uptake
CPU05_RS02120	COG1950	PFAM Membrane protein of
CPU05_RS02125	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CPU05_RS02130	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CPU05_RS02135	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CPU05_RS02145	COG0492	ferredoxin-NADP+ reductase activity
CPU05_RS02150	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CPU05_RS02160	COG0556	nucleotide-excision repair
CPU05_RS02165	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CPU05_RS02170	COG1660	Displays ATPase and GTPase activities
CPU05_RS02175	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CPU05_RS02185	COG1705	Flagellar rod assembly protein muramidase FlgJ
CPU05_RS02185	COG1388	LysM domain
CPU05_RS02195	COG0740	serine-type endopeptidase activity
CPU05_RS02205	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CPU05_RS02210	COG2390	Transcriptional regulator
CPU05_RS02220	COG0126	phosphoglycerate kinase activity
CPU05_RS02225	COG0149	triose-phosphate isomerase activity
CPU05_RS02230	COG0148	phosphopyruvate hydratase activity
CPU05_RS02235	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CPU05_RS02240	COG0557	exoribonuclease II activity
CPU05_RS02245	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CPU05_RS02260	COG0561	phosphatase activity
CPU05_RS02265	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CPU05_RS02270	COG0802	atpase or kinase
CPU05_RS02275	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CPU05_RS02290	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CPU05_RS02295	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CPU05_RS02305	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CPU05_RS02310	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CPU05_RS02330	COG1011	Hydrolase
CPU05_RS02340	COG2188	Transcriptional regulator
CPU05_RS02350	COG3715	PTS system
CPU05_RS02355	COG3716	PTS system mannose fructose sorbose family IID component
CPU05_RS02365	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CPU05_RS02380	COG1695	Transcriptional regulator
CPU05_RS02385	COG1028	Short-chain dehydrogenase reductase Sdr
CPU05_RS02405	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CPU05_RS02415	COG1122	ATPase activity
CPU05_RS02435	COG3716	PTS system mannose fructose sorbose family IID component
CPU05_RS02440	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CPU05_RS02455	COG0730	response to heat
CPU05_RS02460	COG1328	CTP reductase activity
CPU05_RS02465	COG0602	queuosine metabolic process
CPU05_RS02470	COG0396	ATPase activity
CPU05_RS02475	COG0719	Fe-S assembly protein
CPU05_RS02480	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CPU05_RS02485	COG0822	iron-sulfur transferase activity
CPU05_RS02490	COG0719	Fe-S assembly protein
CPU05_RS02495	COG2095	MarC family integral membrane protein
CPU05_RS02510	COG1694	Mazg nucleotide pyrophosphohydrolase
CPU05_RS02515	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CPU05_RS02525	COG1063	alcohol dehydrogenase
CPU05_RS02545	COG5039	Polysaccharide pyruvyl transferase
CPU05_RS02550	COG2814	Major facilitator Superfamily
CPU05_RS02555	COG2261	transglycosylase associated protein
CPU05_RS02570	COG1442	glycosyl transferase family 8
CPU05_RS02600	COG2801	Transposase and inactivated derivatives
CPU05_RS02675	COG3475	LICD family
CPU05_RS02685	COG3397	chitin binding
CPU05_RS02695	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
CPU05_RS02700	COG0351	phosphomethylpyrimidine kinase
CPU05_RS02705	COG0352	thiamine-phosphate diphosphorylase activity
CPU05_RS02715	COG0514	ATP-dependent DNA helicase (RecQ)
CPU05_RS02720	COG5549	protein import
CPU05_RS02720	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CPU05_RS02735	COG0489	protein tyrosine kinase activity
CPU05_RS02740	COG4464	protein tyrosine phosphatase activity
CPU05_RS02745	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CPU05_RS02755	COG1215	transferase activity, transferring glycosyl groups
CPU05_RS02755	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CPU05_RS02760	COG0110	maltose O-acetyltransferase activity
CPU05_RS02765	COG3048	D-serine ammonia-lyase activity
CPU05_RS02775	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CPU05_RS02785	COG1088	dTDP-glucose 4,6-dehydratase activity
CPU05_RS02800	COG1091	dTDP-4-dehydrorhamnose reductase activity
CPU05_RS02805	COG2188	Transcriptional regulator
CPU05_RS02820	COG3715	PTS system
CPU05_RS02830	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
CPU05_RS02830	COG3408	Glycogen debranching enzyme
CPU05_RS02845	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CPU05_RS02845	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CPU05_RS02845	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CPU05_RS02855	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CPU05_RS02855	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CPU05_RS02880	COG0366	Alpha amylase catalytic
CPU05_RS02890	COG2188	Transcriptional regulator
CPU05_RS02920	COG2217	Heavy metal translocating P-type atpase
CPU05_RS02930	COG0531	amino acid
CPU05_RS02945	COG0673	inositol 2-dehydrogenase activity
CPU05_RS02950	COG0513	Belongs to the DEAD box helicase family
CPU05_RS02955	COG1316	TRANSCRIPTIONal
CPU05_RS02975	COG0516	GMP reductase activity
CPU05_RS02980	COG0542	response to heat
CPU05_RS03000	COG0596	Alpha beta hydrolase
CPU05_RS03005	COG0438	transferase activity, transferring glycosyl groups
CPU05_RS03010	COG0438	transferase activity, transferring glycosyl groups
CPU05_RS03145	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CPU05_RS03150	COG0477	Major facilitator Superfamily
CPU05_RS03155	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
CPU05_RS03160	COG0671	phosphoesterase, PA-phosphatase related
CPU05_RS03165	COG0495	leucyl-tRNA aminoacylation
CPU05_RS03170	COG2244	polysaccharide biosynthetic process
CPU05_RS03175	COG1187	pseudouridine synthase activity
CPU05_RS03180	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CPU05_RS03185	COG0589	response to stress
CPU05_RS03200	COG0154	amidase activity
CPU05_RS03205	COG1428	Deoxynucleoside kinase
CPU05_RS03240	COG0367	asparagine synthase
CPU05_RS03245	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CPU05_RS03255	COG1794	racemase activity, acting on amino acids and derivatives
CPU05_RS03265	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CPU05_RS03270	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
CPU05_RS03285	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CPU05_RS03290	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CPU05_RS03310	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CPU05_RS03315	COG1940	carbohydrate kinase activity
CPU05_RS03320	COG2723	6-phospho-beta-galactosidase activity
CPU05_RS03350	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CPU05_RS03350	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CPU05_RS03350	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CPU05_RS03375	COG2017	converts alpha-aldose to the beta-anomer
CPU05_RS03400	COG2160	L-arabinose isomerase activity
CPU05_RS03415	COG0531	amino acid
CPU05_RS03420	COG1297	OPT oligopeptide transporter protein
CPU05_RS03455	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CPU05_RS03480	COG1070	Carbohydrate kinase
CPU05_RS03485	COG2814	Major facilitator Superfamily
CPU05_RS03500	COG0446	pyridine nucleotide-disulphide oxidoreductase
CPU05_RS03505	COG1054	Belongs to the UPF0176 family
CPU05_RS03510	COG1937	Protein conserved in bacteria
CPU05_RS03540	COG2814	Major facilitator Superfamily
CPU05_RS03545	COG1070	Carbohydrate kinase
CPU05_RS03550	COG3254	rhamnose metabolic process
CPU05_RS03555	COG4806	L-rhamnose isomerase
CPU05_RS03560	COG0235	Class ii aldolase
CPU05_RS03565	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CPU05_RS03565	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CPU05_RS03575	COG0383	alpha-mannosidase activity
CPU05_RS03585	COG2723	6-phospho-beta-galactosidase activity
CPU05_RS03605	COG2271	Major facilitator Superfamily
CPU05_RS03610	COG2188	Transcriptional regulator
CPU05_RS03615	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CPU05_RS03650	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CPU05_RS03655	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CPU05_RS03660	COG1609	Transcriptional regulator
CPU05_RS03665	COG2017	converts alpha-aldose to the beta-anomer
CPU05_RS03670	COG2190	(PTS) system
CPU05_RS03670	COG2211	Major facilitator Superfamily
CPU05_RS03685	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CPU05_RS03690	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CPU05_RS03695	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
CPU05_RS03705	COG0531	amino acid
CPU05_RS03730	COG0667	Aldo Keto reductase
CPU05_RS03735	COG0018	arginyl-trna synthetase
CPU05_RS03745	COG1438	arginine binding
CPU05_RS03750	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CPU05_RS03755	COG3679	Belongs to the UPF0342 family
CPU05_RS03760	COG0420	3'-5' exonuclease activity
CPU05_RS03765	COG4717	serine-type aminopeptidase activity
CPU05_RS03775	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CPU05_RS03785	COG0537	adenosine 5'-monophosphoramidase activity
CPU05_RS03790	COG1131	(ABC) transporter
CPU05_RS03795	COG4473	ABC transporter
CPU05_RS03800	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CPU05_RS03810	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CPU05_RS03815	COG1674	ftsk spoiiie
CPU05_RS03820	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CPU05_RS03825	COG0670	Belongs to the BI1 family
CPU05_RS03830	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CPU05_RS03830	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CPU05_RS03840	COG0237	dephospho-CoA kinase activity
CPU05_RS03845	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CPU05_RS03855	COG1484	DNA-dependent DNA replication
CPU05_RS03860	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CPU05_RS03865	COG3275	phosphorelay sensor kinase activity
CPU05_RS03870	COG3279	Response regulator of the LytR AlgR family
CPU05_RS03880	COG1346	cytolysis
CPU05_RS03885	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CPU05_RS03890	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CPU05_RS03895	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CPU05_RS03900	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
CPU05_RS03905	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CPU05_RS03910	COG1534	Rna-binding protein
CPU05_RS03915	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CPU05_RS03920	COG1713	HD superfamily hydrolase involved in NAD metabolism
CPU05_RS03925	COG0799	negative regulation of ribosome biogenesis
CPU05_RS03930	COG2226	methyltransferase
CPU05_RS03935	COG1323	Belongs to the UPF0348 family
CPU05_RS03940	COG1399	metal-binding, possibly nucleic acid-binding protein
CPU05_RS03945	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CPU05_RS03950	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CPU05_RS03955	COG0745	RESPONSE REGULATOR receiver
CPU05_RS03960	COG5002	protein histidine kinase activity
CPU05_RS03965	COG2814	Major facilitator Superfamily
CPU05_RS03970	COG3119	arylsulfatase activity
CPU05_RS03970	COG3408	Glycogen debranching enzyme
CPU05_RS03975	COG0706	membrane insertase activity
CPU05_RS03980	COG1254	Belongs to the acylphosphatase family
CPU05_RS03985	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CPU05_RS03995	COG1733	regulation of RNA biosynthetic process
CPU05_RS04000	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CPU05_RS04005	COG0072	phenylalanine-tRNA ligase activity
CPU05_RS04005	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CPU05_RS04010	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CPU05_RS04015	COG0572	uridine kinase
CPU05_RS04020	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CPU05_RS04025	COG4485	Bacterial membrane protein, YfhO
CPU05_RS04030	COG0768	penicillin binding
CPU05_RS04035	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CPU05_RS04040	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CPU05_RS04045	COG0705	Rhomboid family
CPU05_RS04055	COG1940	carbohydrate kinase activity
CPU05_RS04060	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CPU05_RS04070	COG0584	glycerophosphoryl diester phosphodiesterase
CPU05_RS04075	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CPU05_RS04080	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
CPU05_RS04085	COG0789	Transcriptional regulator
CPU05_RS04130	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CPU05_RS04140	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CPU05_RS04145	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CPU05_RS04150	COG1302	Protein conserved in bacteria
CPU05_RS04155	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CPU05_RS04165	COG1570	exodeoxyribonuclease VII activity
CPU05_RS04170	COG1722	exodeoxyribonuclease VII activity
CPU05_RS04180	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CPU05_RS04185	COG1438	arginine binding
CPU05_RS04190	COG0497	DNA recombination
CPU05_RS04205	COG1758	RNA polymerase activity
CPU05_RS04210	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CPU05_RS04215	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CPU05_RS04220	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CPU05_RS04225	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CPU05_RS04225	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CPU05_RS04235	COG0515	serine threonine protein kinase
CPU05_RS04235	COG2815	serine threonine protein kinase
CPU05_RS04240	COG1162	GTPase activity
CPU05_RS04245	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CPU05_RS04255	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CPU05_RS04270	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CPU05_RS04275	COG0416	fatty acid biosynthetic process
CPU05_RS04280	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CPU05_RS04285	COG0571	ribonuclease III activity
CPU05_RS04290	COG1196	nuclear chromosome segregation
CPU05_RS04295	COG0552	protein localization to endoplasmic reticulum
CPU05_RS04300	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
CPU05_RS04305	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CPU05_RS04310	COG0228	four-way junction DNA binding
CPU05_RS04315	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CPU05_RS04320	COG0336	Belongs to the RNA methyltransferase TrmD family
CPU05_RS04325	COG4619	ABC transporter
CPU05_RS04330	COG0390	transport system, permease component
CPU05_RS04335	COG0335	large ribosomal subunit rRNA binding
CPU05_RS04345	COG0393	Putative heavy-metal-binding
CPU05_RS04355	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CPU05_RS04360	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CPU05_RS04370	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CPU05_RS04375	COG1028	Short-chain dehydrogenase reductase Sdr
CPU05_RS04380	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CPU05_RS04385	COG0511	ligase activity, forming carbon-carbon bonds
CPU05_RS04395	COG0439	Biotin carboxylase
CPU05_RS04400	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CPU05_RS04405	COG0825	malonyl-CoA metabolic process
CPU05_RS04410	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CPU05_RS04425	COG3425	synthase
CPU05_RS04435	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CPU05_RS04440	COG4224	UPF0291 protein
CPU05_RS04445	COG3763	UPF0154 protein
CPU05_RS04450	COG0204	Acyl-transferase
CPU05_RS04455	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CPU05_RS04475	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CPU05_RS04480	COG0528	UMP kinase activity
CPU05_RS04485	COG0233	cytoplasmic translational termination
CPU05_RS04490	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CPU05_RS04495	COG4589	Belongs to the CDS family
CPU05_RS04500	COG0750	zinc metalloprotease
CPU05_RS04505	COG0442	prolyl-tRNA aminoacylation
CPU05_RS04510	COG2176	DNA-directed DNA polymerase activity
CPU05_RS04515	COG0779	Required for maturation of 30S ribosomal subunits
CPU05_RS04520	COG0195	Participates in both transcription termination and antitermination
CPU05_RS04525	COG2740	Nucleic-acid-binding protein implicated in transcription termination
CPU05_RS04535	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CPU05_RS04540	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CPU05_RS04550	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CPU05_RS04555	COG0196	riboflavin kinase activity
CPU05_RS04560	COG1420	regulation of RNA biosynthetic process
CPU05_RS04565	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CPU05_RS04570	COG0443	Heat shock 70 kDa protein
CPU05_RS04575	COG0484	heat shock protein binding
CPU05_RS04580	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
CPU05_RS04585	COG2155	Conserved Protein
CPU05_RS04595	COG1131	(ABC) transporter
CPU05_RS04610	COG0583	DNA-binding transcription factor activity
CPU05_RS04615	COG2223	nitrite transmembrane transporter activity
CPU05_RS04620	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CPU05_RS04625	COG4708	membrane
CPU05_RS04635	COG1028	Short-chain dehydrogenase reductase Sdr
CPU05_RS04650	COG0531	amino acid
CPU05_RS04655	COG3250	beta-galactosidase activity
CPU05_RS04685	COG1942	4-Oxalocrotonate Tautomerase
CPU05_RS04690	COG0561	phosphatase activity
CPU05_RS04695	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
CPU05_RS04695	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CPU05_RS04700	COG1304	FMN binding
CPU05_RS04720	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CPU05_RS04720	COG1199	ATP-dependent helicase activity
CPU05_RS04730	COG3935	DnaD domain protein
CPU05_RS04735	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CPU05_RS04740	COG3331	DNA recombination
CPU05_RS04745	COG4474	Belongs to the UPF0398 family
CPU05_RS04750	COG3599	regulation of cell shape
CPU05_RS04760	COG0116	Belongs to the methyltransferase superfamily
CPU05_RS04765	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CPU05_RS04775	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CPU05_RS04785	COG0564	pseudouridine synthase activity
CPU05_RS04790	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CPU05_RS04800	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CPU05_RS04805	COG1293	RNA-binding protein homologous to eukaryotic snRNP
CPU05_RS04815	COG1307	EDD domain protein, DegV family
CPU05_RS04825	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CPU05_RS04835	COG1609	Transcriptional regulator
CPU05_RS04845	COG1288	antiporter activity
CPU05_RS04850	COG1316	TRANSCRIPTIONal
CPU05_RS04855	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CPU05_RS04860	COG2814	Major facilitator Superfamily
CPU05_RS04870	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CPU05_RS04875	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CPU05_RS04875	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CPU05_RS04885	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CPU05_RS04885	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CPU05_RS04895	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CPU05_RS04900	COG0285	dihydrofolate synthase activity
CPU05_RS04905	COG0302	gtp cyclohydrolase
CPU05_RS04910	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CPU05_RS04910	COG0302	gtp cyclohydrolase
CPU05_RS04930	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CPU05_RS04935	COG1929	Belongs to the glycerate kinase type-1 family
CPU05_RS04940	COG2610	gluconate transmembrane transporter activity
CPU05_RS04945	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CPU05_RS04950	COG1227	inorganic diphosphatase activity
CPU05_RS04955	COG0583	DNA-binding transcription factor activity
CPU05_RS04965	COG0187	DNA topoisomerase II activity
CPU05_RS04975	COG2801	Transposase and inactivated derivatives
CPU05_RS04990	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CPU05_RS04995	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CPU05_RS05000	COG4974	Belongs to the 'phage' integrase family
CPU05_RS05005	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CPU05_RS05010	COG0758	DNA mediated transformation
CPU05_RS05015	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CPU05_RS05030	COG0446	pyridine nucleotide-disulphide oxidoreductase
CPU05_RS05035	COG0477	Major facilitator Superfamily
CPU05_RS05040	COG0640	Transcriptional regulator
CPU05_RS05055	COG0183	Belongs to the thiolase family
CPU05_RS05090	COG1131	(ABC) transporter
CPU05_RS05120	COG1309	transcriptional regulator
CPU05_RS05130	COG0151	Belongs to the GarS family
CPU05_RS05135	COG0138	bifunctional purine biosynthesis protein purh
CPU05_RS05140	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CPU05_RS05145	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CPU05_RS05155	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CPU05_RS05165	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CPU05_RS05170	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CPU05_RS05175	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CPU05_RS05180	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CPU05_RS05200	COG1131	(ABC) transporter
CPU05_RS05205	COG1395	domain, Protein
CPU05_RS05230	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CPU05_RS05235	COG2022	thiamine diphosphate biosynthetic process
CPU05_RS05240	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CPU05_RS05270	COG3052	prosthetic group binding
CPU05_RS05285	COG0281	malic enzyme
CPU05_RS05295	COG0105	UTP biosynthetic process
CPU05_RS05305	COG2801	Transposase and inactivated derivatives
CPU05_RS05360	COG2723	6-phospho-beta-galactosidase activity
CPU05_RS05365	COG2190	(PTS) system
CPU05_RS05365	COG1263	PTS System
CPU05_RS05365	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CPU05_RS05380	COG0531	amino acid
CPU05_RS05385	COG1393	Belongs to the ArsC family
CPU05_RS05390	COG0793	Belongs to the peptidase S41A family
CPU05_RS05390	COG3409	Peptidoglycan-binding domain 1 protein
CPU05_RS05395	COG4479	Belongs to the UPF0346 family
CPU05_RS05405	COG2755	lipolytic protein G-D-S-L family
CPU05_RS05410	COG1307	EDD domain protein, DegV family
CPU05_RS05420	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CPU05_RS05425	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CPU05_RS05430	COG0488	(ABC) transporter
CPU05_RS05435	COG0617	tRNA 3'-terminal CCA addition
CPU05_RS05440	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CPU05_RS05455	COG0457	Tetratricopeptide repeat
CPU05_RS05465	COG1160	GTP binding
CPU05_RS05470	COG0539	negative regulation of cytoplasmic translation
CPU05_RS05475	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CPU05_RS05485	COG0514	ATP-dependent DNA helicase (RecQ)
CPU05_RS05495	COG1187	pseudouridine synthase activity
CPU05_RS05500	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CPU05_RS05505	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CPU05_RS05525	COG2707	UPF0756 membrane protein
CPU05_RS05535	COG0205	6-phosphofructokinase activity
CPU05_RS05550	COG0542	response to heat
CPU05_RS05555	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CPU05_RS05560	COG2384	SAM-dependent methyltransferase
CPU05_RS05565	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CPU05_RS05570	COG0358	DNA primase activity
CPU05_RS05575	COG0751	glycine-tRNA ligase activity
CPU05_RS05580	COG0752	glycyl-tRNA synthetase alpha subunit
CPU05_RS05585	COG1381	Involved in DNA repair and RecF pathway recombination
CPU05_RS05590	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CPU05_RS05600	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CPU05_RS05605	COG1702	phosphate starvation-inducible protein PhoH
CPU05_RS05615	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CPU05_RS05620	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CPU05_RS05630	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CPU05_RS05635	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CPU05_RS05650	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CPU05_RS05655	COG0124	histidyl-tRNA synthetase
CPU05_RS05665	COG0546	phosphoglycolate phosphatase activity
CPU05_RS05670	COG1490	D-aminoacyl-tRNA deacylase activity
CPU05_RS05675	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CPU05_RS05685	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CPU05_RS05690	COG2264	protein methyltransferase activity
CPU05_RS05695	COG2233	PERMEase
CPU05_RS05715	COG0436	Aminotransferase
CPU05_RS05720	COG1088	dTDP-glucose 4,6-dehydratase activity
CPU05_RS05730	COG2153	protein acetylation
CPU05_RS05735	COG1132	(ABC) transporter
CPU05_RS05745	COG0778	Nitroreductase
CPU05_RS05770	COG1304	FMN binding
CPU05_RS05960	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
CPU05_RS05990	COG0629	single-stranded DNA binding
CPU05_RS06035	COG1396	sequence-specific DNA binding
CPU05_RS06080	COG2261	transglycosylase associated protein
CPU05_RS06095	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CPU05_RS06135	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CPU05_RS06140	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CPU05_RS06140	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CPU05_RS06145	COG0300	oxidoreductase activity
CPU05_RS06150	COG1234	tRNA 3'-trailer cleavage
CPU05_RS06160	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CPU05_RS06165	COG0322	excinuclease ABC activity
CPU05_RS06170	COG1126	abc transporter atp-binding protein
CPU05_RS06175	COG0765	amino acid transport
CPU05_RS06185	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CPU05_RS06190	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CPU05_RS06195	COG0544	peptidyl-prolyl cis-trans isomerase activity
CPU05_RS06200	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CPU05_RS06215	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CPU05_RS06220	COG0268	Binds directly to 16S ribosomal RNA
CPU05_RS06235	COG2131	deaminase
CPU05_RS06240	COG1555	photosystem II stabilization
CPU05_RS06240	COG1596	polysaccharide export
CPU05_RS06245	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CPU05_RS06250	COG0742	ribosomal rna small subunit methyltransferase
CPU05_RS06255	COG4471	UPF0298 protein
CPU05_RS06260	COG0772	Belongs to the SEDS family
CPU05_RS06265	COG1217	gtp-binding protein TYPA
CPU05_RS06270	COG0483	inositol monophosphate 1-phosphatase activity
CPU05_RS06275	COG4476	Belongs to the UPF0223 family
CPU05_RS06280	COG0242	peptide deformylase activity
CPU05_RS06290	COG5503	Protein of unknown function (DUF1447)
CPU05_RS06305	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CPU05_RS06305	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CPU05_RS06305	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CPU05_RS06310	COG1105	Belongs to the carbohydrate kinase PfkB family
CPU05_RS06315	COG1349	DNA-binding transcription factor activity
CPU05_RS06320	COG0628	permease
CPU05_RS06325	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CPU05_RS06330	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CPU05_RS06355	COG1104	cysteine desulfurase activity
CPU05_RS06360	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CPU05_RS06370	COG0494	nUDIX hydrolase
CPU05_RS06375	COG1278	Cold shock
CPU05_RS06380	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CPU05_RS06385	COG3599	regulation of cell shape
CPU05_RS06390	COG2302	S4 RNA-binding domain
CPU05_RS06405	COG0849	cell division
CPU05_RS06410	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CPU05_RS06415	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CPU05_RS06420	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CPU05_RS06425	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CPU05_RS06430	COG0768	penicillin binding
CPU05_RS06440	COG0275	rRNA processing
CPU05_RS06445	COG2001	Belongs to the MraZ family
CPU05_RS06455	COG1674	ftsk spoiiie
CPU05_RS06465	COG0628	permease
CPU05_RS06475	COG2706	6-phosphogluconolactonase activity
CPU05_RS06480	COG3142	Participates in the control of copper homeostasis
CPU05_RS06485	COG2239	Acts as a magnesium transporter
CPU05_RS06490	COG0564	pseudouridine synthase activity
CPU05_RS06515	COG4862	establishment of competence for transformation
CPU05_RS06520	COG1393	Belongs to the ArsC family
CPU05_RS06525	COG1234	tRNA 3'-trailer cleavage
CPU05_RS06605	COG1185	polyribonucleotide nucleotidyltransferase activity
CPU05_RS06610	COG0586	Pfam SNARE associated Golgi protein
CPU05_RS06620	COG0647	UMP catabolic process
CPU05_RS06625	COG4470	Protein conserved in bacteria
CPU05_RS06635	COG0827	DNA restriction-modification system
CPU05_RS06660	COG4537	Required for transformation and DNA binding
CPU05_RS06665	COG1459	type II secretion system
CPU05_RS06670	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CPU05_RS06680	COG0217	transcriptional regulatory protein
CPU05_RS06685	COG2132	Multicopper oxidase
CPU05_RS06690	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CPU05_RS06695	COG1335	isochorismatase
CPU05_RS06700	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CPU05_RS06705	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CPU05_RS06725	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CPU05_RS06730	COG1609	Transcriptional regulator
CPU05_RS06735	COG0006	proline dipeptidase activity
CPU05_RS06750	COG0668	transmembrane transport
CPU05_RS06755	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CPU05_RS06760	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CPU05_RS06765	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CPU05_RS06765	COG0574	Belongs to the PEP-utilizing enzyme family
CPU05_RS06770	COG3118	belongs to the thioredoxin family
CPU05_RS06775	COG1193	negative regulation of DNA recombination
CPU05_RS06780	COG3906	Belongs to the UPF0473 family
CPU05_RS06785	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CPU05_RS06790	COG4472	Bacterial protein of unknown function (DUF965)
CPU05_RS06795	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CPU05_RS06800	COG0513	Belongs to the DEAD box helicase family
CPU05_RS06805	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CPU05_RS06810	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CPU05_RS06815	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CPU05_RS06820	COG1862	Preprotein translocase
CPU05_RS06830	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CPU05_RS06835	COG2255	four-way junction helicase activity
CPU05_RS06840	COG0632	four-way junction helicase activity
CPU05_RS06845	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CPU05_RS06850	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CPU05_RS06855	COG1418	mRNA catabolic process
CPU05_RS06870	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CPU05_RS06880	COG0300	oxidoreductase activity
CPU05_RS06885	COG0612	Peptidase, M16
CPU05_RS06890	COG0612	Peptidase, M16
CPU05_RS06895	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CPU05_RS06905	COG1126	abc transporter atp-binding protein
CPU05_RS06910	COG0765	amino acid transport
CPU05_RS06925	COG2003	Belongs to the UPF0758 family
CPU05_RS06935	COG0525	valine-tRNA ligase activity
CPU05_RS06945	COG0301	tRNA thio-modification
CPU05_RS06950	COG1104	cysteine desulfurase activity
CPU05_RS06955	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
CPU05_RS06960	COG1956	GAF domain-containing protein
CPU05_RS06965	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CPU05_RS06970	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CPU05_RS06985	COG0589	response to stress
CPU05_RS07000	COG1181	Belongs to the D-alanine--D-alanine ligase family
CPU05_RS07010	COG0531	amino acid
CPU05_RS07025	COG1131	(ABC) transporter
CPU05_RS07030	COG1725	Transcriptional regulator
CPU05_RS07040	COG1464	Belongs to the NlpA lipoprotein family
CPU05_RS07045	COG2011	ABC-type metal ion transport system permease component
CPU05_RS07050	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CPU05_RS07065	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CPU05_RS07070	COG4836	Membrane
CPU05_RS07075	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CPU05_RS07080	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CPU05_RS07085	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CPU05_RS07090	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CPU05_RS07095	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CPU05_RS07100	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CPU05_RS07105	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CPU05_RS07110	COG0356	it plays a direct role in the translocation of protons across the membrane
CPU05_RS07130	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CPU05_RS07135	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CPU05_RS07140	COG0009	L-threonylcarbamoyladenylate synthase
CPU05_RS07145	COG2890	protein-(glutamine-N5) methyltransferase activity
CPU05_RS07155	COG1435	thymidine kinase activity
CPU05_RS07160	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CPU05_RS07165	COG3442	glutamine amidotransferase
CPU05_RS07170	COG1482	cell wall glycoprotein biosynthetic process
CPU05_RS07180	COG1132	(ABC) transporter
CPU05_RS07200	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CPU05_RS07225	COG1053	succinate dehydrogenase
CPU05_RS07225	COG0431	NADPH-dependent FMN reductase
CPU05_RS07225	COG3976	FMN-binding domain protein
CPU05_RS07235	COG0166	Belongs to the GPI family
CPU05_RS07240	COG4975	Glucose uptake
CPU05_RS07250	COG3850	Histidine kinase
CPU05_RS07250	COG5002	protein histidine kinase activity
CPU05_RS07255	COG0745	RESPONSE REGULATOR receiver
CPU05_RS07270	COG0741	lytic transglycosylase activity
CPU05_RS07280	COG2610	gluconate transmembrane transporter activity
CPU05_RS07285	COG1070	Carbohydrate kinase
CPU05_RS07290	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
CPU05_RS07295	COG1737	Transcriptional regulator
CPU05_RS07335	COG0653	protein targeting
CPU05_RS07355	COG0730	response to heat
CPU05_RS07360	COG1368	sulfuric ester hydrolase activity
CPU05_RS07365	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CPU05_RS07370	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CPU05_RS07375	COG0628	permease
CPU05_RS07380	COG3557	Belongs to the UPF0374 family
CPU05_RS07385	COG2137	regulation of response to DNA damage stimulus
CPU05_RS07390	COG0716	FMN binding
CPU05_RS07410	COG4974	Belongs to the 'phage' integrase family
CPU05_RS07425	COG0732	type I restriction modification DNA specificity domain
CPU05_RS07475	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CPU05_RS07475	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CPU05_RS07530	COG1802	Transcriptional regulator
CPU05_RS07530	COG4626	Terminase
CPU05_RS07540	COG4695	Portal protein
CPU05_RS07600	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CPU05_RS07605	COG1597	lipid kinase activity
CPU05_RS07615	COG0154	amidase activity
CPU05_RS07625	COG4851	CamS sex pheromone cAM373 precursor
CPU05_RS07635	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CPU05_RS07640	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CPU05_RS07645	COG1705	Flagellar rod assembly protein muramidase FlgJ
CPU05_RS07685	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CPU05_RS07700	COG0531	amino acid
CPU05_RS07710	COG1983	PspC domain protein
CPU05_RS07720	COG1131	(ABC) transporter
CPU05_RS07745	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CPU05_RS07750	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CPU05_RS07765	COG1122	ATPase activity
CPU05_RS07770	COG1122	ATPase activity
CPU05_RS07775	COG0203	ribosomal protein L17
CPU05_RS07780	COG0202	RNA polymerase activity
CPU05_RS07785	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CPU05_RS07790	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CPU05_RS07795	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CPU05_RS07800	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CPU05_RS07815	COG0200	Binds to the 23S rRNA
CPU05_RS07820	COG1841	ribosomal large subunit assembly
CPU05_RS07825	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CPU05_RS07830	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CPU05_RS07835	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CPU05_RS07840	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CPU05_RS07845	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CPU05_RS07850	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CPU05_RS07855	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CPU05_RS07860	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CPU05_RS07870	COG0255	Belongs to the universal ribosomal protein uL29 family
CPU05_RS07875	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CPU05_RS07880	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CPU05_RS07885	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CPU05_RS07890	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CPU05_RS07895	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CPU05_RS07900	COG0089	rRNA binding
CPU05_RS07905	COG0088	Forms part of the polypeptide exit tunnel
CPU05_RS07910	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CPU05_RS07915	COG0051	transcription antitermination factor activity, RNA binding
CPU05_RS07925	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CPU05_RS07930	COG0049	tRNA binding
CPU05_RS07935	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CPU05_RS07945	COG1957	nucleoside hydrolase
CPU05_RS07950	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CPU05_RS07955	COG0085	RNA polymerase activity
CPU05_RS07960	COG0542	response to heat
CPU05_RS07965	COG4463	regulation of RNA biosynthetic process
CPU05_RS07970	COG0028	Belongs to the TPP enzyme family
CPU05_RS08015	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CPU05_RS08020	COG1428	Deoxynucleoside kinase
CPU05_RS08025	COG0833	amino acid
CPU05_RS08040	COG1316	TRANSCRIPTIONal
CPU05_RS08050	COG2966	Psort location CytoplasmicMembrane, score
CPU05_RS08055	COG1278	Cold shock
CPU05_RS08060	COG1230	cation diffusion facilitator family transporter
CPU05_RS08070	COG1418	mRNA catabolic process
CPU05_RS08075	COG1418	mRNA catabolic process
CPU05_RS08085	COG0564	pseudouridine synthase activity
CPU05_RS08100	COG4690	dipeptidase activity
CPU05_RS08110	COG4152	abc transporter atp-binding protein
CPU05_RS08115	COG1476	TRANSCRIPTIONal
CPU05_RS08140	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CPU05_RS08150	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CPU05_RS08160	COG1214	PFAM Peptidase M22, glycoprotease
CPU05_RS08165	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CPU05_RS08180	COG4467	Involved in initiation control of chromosome replication
CPU05_RS08185	COG0470	DNA polymerase III
CPU05_RS08190	COG3870	Protein conserved in bacteria
CPU05_RS08195	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CPU05_RS08200	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CPU05_RS08205	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CPU05_RS08210	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CPU05_RS08225	COG2813	Specifically methylates the guanine in position
CPU05_RS08230	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CPU05_RS08235	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CPU05_RS08240	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CPU05_RS08245	COG0222	ribosome binding
CPU05_RS08250	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CPU05_RS08255	COG0081	regulation of translation
CPU05_RS08265	COG0250	Participates in transcription elongation, termination and antitermination
CPU05_RS08275	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CPU05_RS08285	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CPU05_RS08290	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
CPU05_RS08295	COG0215	cysteine-tRNA ligase activity
CPU05_RS08300	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CPU05_RS08305	COG4956	integral membrane protein (PIN domain superfamily)
CPU05_RS08310	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CPU05_RS08325	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CPU05_RS08335	COG0588	phosphoglycerate mutase activity
CPU05_RS08340	COG0825	malonyl-CoA metabolic process
CPU05_RS08350	COG0439	Biotin carboxylase
CPU05_RS08360	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CPU05_RS08375	COG3933	PFAM sigma-54 factor interaction domain-containing protein
CPU05_RS08375	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CPU05_RS08385	COG3716	PTS system mannose fructose sorbose family IID component
CPU05_RS08390	COG3715	PTS system
CPU05_RS08405	COG3091	SprT-like family
CPU05_RS08410	COG2183	response to ionizing radiation
CPU05_RS08430	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CPU05_RS08435	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
CPU05_RS08440	COG2188	Transcriptional regulator
CPU05_RS08450	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CPU05_RS08455	COG1064	alcohol dehydrogenase
CPU05_RS08475	COG3104	oligopeptide transport
CPU05_RS08515	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CPU05_RS08520	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CPU05_RS08525	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CPU05_RS08545	COG1098	S1 RNA binding domain
CPU05_RS08555	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CPU05_RS08560	COG2244	polysaccharide biosynthetic process
CPU05_RS08570	COG0193	aminoacyl-tRNA hydrolase activity
CPU05_RS08590	COG2337	Toxic component of a toxin-antitoxin (TA) module
CPU05_RS08615	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CPU05_RS08625	COG0501	Belongs to the peptidase M48B family
CPU05_RS08630	COG1704	LemA family
CPU05_RS08635	COG3764	Sortase (surface protein transpeptidase)
CPU05_RS08645	COG0254	rRNA binding
CPU05_RS08650	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CPU05_RS08655	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CPU05_RS08665	COG3343	RNA polymerase activity
CPU05_RS08675	COG1078	dGTPase activity
CPU05_RS08695	COG1940	carbohydrate kinase activity
CPU05_RS08710	COG0534	Mate efflux family protein
CPU05_RS08725	COG0546	phosphoglycolate phosphatase activity
CPU05_RS08735	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CPU05_RS08740	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
CPU05_RS08745	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CPU05_RS08755	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CPU05_RS08765	COG1268	BioY protein
CPU05_RS08770	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
CPU05_RS08780	COG2814	Major facilitator Superfamily
CPU05_RS08790	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CPU05_RS08795	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CPU05_RS08805	COG0463	Glycosyl transferase, family 2
CPU05_RS08810	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CPU05_RS08810	COG0463	Glycosyl transferase, family 2
CPU05_RS08815	COG1134	teichoic acid transport
CPU05_RS08820	COG1682	transport, permease protein
CPU05_RS08830	COG0463	Glycosyl transferase, family 2
CPU05_RS08835	COG2246	polysaccharide biosynthetic process
CPU05_RS08855	COG1193	negative regulation of DNA recombination
CPU05_RS08870	COG0114	fumarate hydratase activity
CPU05_RS08880	COG0583	DNA-binding transcription factor activity
CPU05_RS08885	COG0667	Aldo Keto reductase
CPU05_RS08910	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CPU05_RS08955	COG1164	Oligoendopeptidase f
CPU05_RS08970	COG2211	Major facilitator Superfamily
CPU05_RS08975	COG2814	Major facilitator Superfamily
CPU05_RS08980	COG1854	S-ribosylhomocysteine lyase activity
CPU05_RS08985	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CPU05_RS08990	COG0110	maltose O-acetyltransferase activity
CPU05_RS08995	COG0446	pyridine nucleotide-disulphide oxidoreductase
CPU05_RS09015	COG0697	spore germination
CPU05_RS09025	COG0488	(ABC) transporter
CPU05_RS09035	COG0402	S-adenosylhomocysteine deaminase activity
CPU05_RS09045	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CPU05_RS09050	COG1174	glycine betaine transport
CPU05_RS09055	COG1732	Glycine betaine
CPU05_RS09075	COG0673	inositol 2-dehydrogenase activity
CPU05_RS09090	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
CPU05_RS09095	COG1461	Dihydroxyacetone kinase
CPU05_RS09100	COG2376	Dihydroxyacetone kinase
CPU05_RS09105	COG2357	RelA SpoT domain protein
CPU05_RS09115	COG2249	NAD(P)H dehydrogenase (quinone) activity
CPU05_RS09140	COG2261	transglycosylase associated protein
CPU05_RS09145	COG0667	Aldo Keto reductase
CPU05_RS09150	COG0561	phosphatase activity
CPU05_RS09155	COG0284	orotidine-5'-phosphate decarboxylase activity
CPU05_RS09160	COG0242	peptide deformylase activity
CPU05_RS09170	COG1846	Transcriptional regulator
CPU05_RS09185	COG1131	(ABC) transporter
CPU05_RS09190	COG0789	Transcriptional regulator
CPU05_RS09195	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CPU05_RS09205	COG0583	DNA-binding transcription factor activity
CPU05_RS09210	COG1902	pentaerythritol trinitrate reductase activity
CPU05_RS09215	COG4975	Glucose uptake
CPU05_RS09220	COG1869	D-ribose catabolic process
CPU05_RS09230	COG1609	Transcriptional regulator
CPU05_RS09235	COG1914	H( )-stimulated, divalent metal cation uptake system
CPU05_RS09265	COG0702	epimerase
CPU05_RS09290	COG0588	phosphoglycerate mutase activity
CPU05_RS09295	COG0148	phosphopyruvate hydratase activity
CPU05_RS09305	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CPU05_RS09325	COG1686	Belongs to the peptidase S11 family
CPU05_RS09330	COG5002	protein histidine kinase activity
CPU05_RS09335	COG0745	RESPONSE REGULATOR receiver
CPU05_RS09340	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CPU05_RS09355	COG0012	GTP binding
CPU05_RS09360	COG4481	Protein conserved in bacteria
CPU05_RS09365	COG1475	DNA binding
CPU05_RS09370	COG0357	Ribosomal RNA small subunit methyltransferase G
CPU05_RS09385	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CPU05_RS09395	COG0791	NLP P60 protein
CPU05_RS09405	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CPU05_RS09410	COG2197	response regulator
CPU05_RS09415	COG4585	Histidine kinase
CPU05_RS09420	COG0842	Transport permease protein
CPU05_RS09430	COG0586	Pfam SNARE associated Golgi protein
CPU05_RS09450	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CPU05_RS09450	COG2755	lipolytic protein G-D-S-L family
CPU05_RS09465	COG1136	(ABC) transporter
CPU05_RS09485	COG2200	EAL domain
CPU05_RS09490	COG2199	diguanylate cyclase activity
CPU05_RS09500	COG3507	Belongs to the glycosyl hydrolase 43 family
CPU05_RS09505	COG2211	Major facilitator Superfamily
CPU05_RS09520	COG2115	Belongs to the xylose isomerase family
CPU05_RS09535	COG2017	converts alpha-aldose to the beta-anomer
CPU05_RS09555	COG2222	sugar isomerase
CPU05_RS09560	COG2188	Transcriptional regulator
CPU05_RS09565	COG3716	PTS system mannose fructose sorbose family IID component
CPU05_RS09570	COG3715	PTS system
CPU05_RS09575	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CPU05_RS09605	COG4708	membrane
CPU05_RS09615	COG0604	alcohol dehydrogenase
CPU05_RS09640	COG0095	Lipoate-protein ligase
CPU05_RS09645	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CPU05_RS09650	COG2723	6-phospho-beta-galactosidase activity
CPU05_RS09655	COG2188	Transcriptional regulator
CPU05_RS09665	COG1511	domain protein
CPU05_RS09665	COG1511	domain protein
CPU05_RS09670	COG0640	Transcriptional regulator
CPU05_RS09685	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
CPU05_RS09690	COG1609	Transcriptional regulator
CPU05_RS09705	COG0246	Mannitol dehydrogenase
CPU05_RS09710	COG1904	glucuronate isomerase
CPU05_RS09720	COG2211	Major facilitator Superfamily
CPU05_RS09745	COG0438	transferase activity, transferring glycosyl groups
CPU05_RS09795	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CPU05_RS09800	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CPU05_RS09805	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CPU05_RS09825	COG0745	RESPONSE REGULATOR receiver
CPU05_RS09840	COG0667	Aldo Keto reductase
CPU05_RS09875	COG3321	synthase
CPU05_RS09875	COG0604	alcohol dehydrogenase
CPU05_RS09880	COG0640	Transcriptional regulator
CPU05_RS09930	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CPU05_RS09935	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CPU05_RS09935	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CPU05_RS09940	COG1609	Transcriptional regulator
CPU05_RS09955	COG1970	mechanosensitive ion channel activity
CPU05_RS09965	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CPU05_RS09985	COG1136	(ABC) transporter
CPU05_RS09985	COG0577	efflux transmembrane transporter activity
CPU05_RS10005	COG2832	Protein of unknown function (DUF454)
CPU05_RS10020	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CPU05_RS10025	COG1074	ATP-dependent DNA helicase activity
CPU05_RS10030	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
CPU05_RS10045	COG0519	Catalyzes the synthesis of GMP from XMP
CPU05_RS10055	COG1757	Na H antiporter
CPU05_RS10060	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CPU05_RS10065	COG0537	adenosine 5'-monophosphoramidase activity
CPU05_RS10075	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CPU05_RS10085	COG1446	asparaginase
CPU05_RS10095	COG2188	Transcriptional regulator
CPU05_RS10100	COG3022	response to hydroperoxide
CPU05_RS10105	COG0445	tRNA wobble uridine modification
CPU05_RS10110	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CPU05_RS10115	COG0706	membrane insertase activity
CPU05_RS10120	COG0594	ribonuclease P activity
CPU05_RS10125	COG0230	Belongs to the bacterial ribosomal protein bL34 family