locus-tag	class	description
HN015_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HN015_RS00010	COG0592	DNA-directed DNA polymerase activity
HN015_RS00015	COG2501	S4 domain
HN015_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HN015_RS00025	COG0187	DNA topoisomerase II activity
HN015_RS00035	COG0360	Binds together with S18 to 16S ribosomal RNA
HN015_RS00040	COG0629	single-stranded DNA binding
HN015_RS00045	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HN015_RS00055	COG0359	binds to the 23S rRNA
HN015_RS00060	COG0305	Participates in initiation and elongation during chromosome replication
HN015_RS00065	COG2814	Major facilitator Superfamily
HN015_RS00080	COG0488	(ABC) transporter
HN015_RS00095	COG1136	(ABC) transporter
HN015_RS00105	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HN015_RS00120	COG0431	NADPH-dependent FMN reductase
HN015_RS00130	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HN015_RS00140	COG2235	arginine
HN015_RS00165	COG0789	Transcriptional regulator
HN015_RS00170	COG2076	Multidrug Resistance protein
HN015_RS00180	COG1272	protein, Hemolysin III
HN015_RS00215	COG1373	ATPase (AAA superfamily
HN015_RS00265	COG0583	DNA-binding transcription factor activity
HN015_RS00270	COG0110	maltose O-acetyltransferase activity
HN015_RS00300	COG1131	(ABC) transporter
HN015_RS00305	COG2188	Transcriptional regulator
HN015_RS00345	COG0583	DNA-binding transcription factor activity
HN015_RS00350	COG0656	L-ascorbic acid biosynthetic process
HN015_RS00405	COG1215	transferase activity, transferring glycosyl groups
HN015_RS00410	COG2723	6-phospho-beta-galactosidase activity
HN015_RS00435	COG0667	Aldo Keto reductase
HN015_RS00440	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HN015_RS00450	COG3546	catalase activity
HN015_RS00485	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HN015_RS00500	COG4932	domain protein
HN015_RS00510	COG3775	system Galactitol-specific IIC component
HN015_RS00525	COG1349	DNA-binding transcription factor activity
HN015_RS00540	COG3684	Belongs to the aldolase LacD family
HN015_RS00555	COG1737	Transcriptional regulator
HN015_RS00565	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HN015_RS00565	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HN015_RS00565	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HN015_RS00570	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
HN015_RS00580	COG1028	Short-chain dehydrogenase reductase Sdr
HN015_RS00585	COG4876	unkown
HN015_RS00600	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HN015_RS00610	COG1737	Transcriptional regulator
HN015_RS00615	COG1285	pathogenesis
HN015_RS00620	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HN015_RS00625	COG3715	PTS system
HN015_RS00630	COG3716	PTS system mannose fructose sorbose family IID component
HN015_RS00645	COG2188	Transcriptional regulator
HN015_RS00655	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HN015_RS00670	COG1940	carbohydrate kinase activity
HN015_RS00675	COG2723	6-phospho-beta-galactosidase activity
HN015_RS00680	COG0028	Belongs to the TPP enzyme family
HN015_RS00695	COG0656	L-ascorbic acid biosynthetic process
HN015_RS00715	COG3715	PTS system
HN015_RS00720	COG3716	PTS system mannose fructose sorbose family IID component
HN015_RS00725	COG2222	sugar isomerase
HN015_RS00755	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HN015_RS00760	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HN015_RS00765	COG0813	purine-nucleoside phosphorylase activity
HN015_RS00770	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HN015_RS00780	COG2390	Transcriptional regulator
HN015_RS00785	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HN015_RS00795	COG3940	Belongs to the glycosyl hydrolase 43 family
HN015_RS00815	COG1442	glycosyl transferase family 8
HN015_RS00830	COG1929	Belongs to the glycerate kinase type-1 family
HN015_RS00835	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HN015_RS00840	COG0697	spore germination
HN015_RS00845	COG0438	transferase activity, transferring glycosyl groups
HN015_RS00850	COG0438	transferase activity, transferring glycosyl groups
HN015_RS00855	COG0778	Nitroreductase
HN015_RS00865	COG0351	phosphomethylpyrimidine kinase
HN015_RS00880	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HN015_RS00910	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HN015_RS00915	COG2814	Major facilitator Superfamily
HN015_RS00945	COG0402	S-adenosylhomocysteine deaminase activity
HN015_RS00950	COG1174	glycine betaine transport
HN015_RS00970	COG3973	AAA domain
HN015_RS01005	COG1801	Protein of unknown function DUF72
HN015_RS01010	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HN015_RS01010	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HN015_RS01015	COG0084	hydrolase, TatD family'
HN015_RS01025	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HN015_RS01030	COG4466	Protein conserved in bacteria
HN015_RS01035	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HN015_RS01045	COG0589	response to stress
HN015_RS01055	COG0477	Major facilitator Superfamily
HN015_RS01065	COG3842	ATPase activity
HN015_RS01070	COG4120	Belongs to the binding-protein-dependent transport system permease family
HN015_RS01080	COG2188	Transcriptional regulator
HN015_RS01085	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HN015_RS01090	COG1447	Phosphotransferase system cellobiose-specific component IIA
HN015_RS01095	COG2723	6-phospho-beta-galactosidase activity
HN015_RS01105	COG0446	pyridine nucleotide-disulphide oxidoreductase
HN015_RS01125	COG1288	antiporter activity
HN015_RS01130	COG1573	uracil-dna glycosylase
HN015_RS01135	COG0803	Belongs to the bacterial solute-binding protein 9 family
HN015_RS01140	COG1121	(ABC) transporter
HN015_RS01145	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HN015_RS01150	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HN015_RS01155	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HN015_RS01235	COG4869	propanediol catabolic process
HN015_RS01270	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HN015_RS01280	COG1902	pentaerythritol trinitrate reductase activity
HN015_RS01285	COG2365	Tyrosine phosphatase family
HN015_RS01290	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HN015_RS01315	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HN015_RS01320	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HN015_RS01340	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HN015_RS01345	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HN015_RS01355	COG3590	peptidase
HN015_RS01360	COG2502	aspartate--ammonia ligase
HN015_RS01365	COG2252	PERMEase
HN015_RS01390	COG2855	membrane
HN015_RS01405	COG0561	phosphatase activity
HN015_RS01410	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HN015_RS01415	COG0540	Belongs to the ATCase OTCase family
HN015_RS01420	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HN015_RS01425	COG0505	Belongs to the CarA family
HN015_RS01430	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HN015_RS01435	COG0167	dihydroorotate dehydrogenase activity
HN015_RS01440	COG1053	succinate dehydrogenase
HN015_RS01450	COG2814	Major facilitator Superfamily
HN015_RS01455	COG0346	lactoylglutathione lyase activity
HN015_RS01465	COG0363	glucosamine-6-phosphate deaminase activity
HN015_RS01470	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HN015_RS01475	COG0280	phosphate acetyltransferase
HN015_RS01480	COG0735	belongs to the Fur family
HN015_RS01485	COG2814	Major facilitator Superfamily
HN015_RS01490	COG1295	ribonuclease BN
HN015_RS01500	COG2365	Tyrosine phosphatase family
HN015_RS01505	COG2365	Tyrosine phosphatase family
HN015_RS01510	COG1780	Probably involved in ribonucleotide reductase function
HN015_RS01515	COG0561	phosphatase activity
HN015_RS01520	COG1131	(ABC) transporter
HN015_RS01525	COG3559	Exporter of polyketide antibiotics
HN015_RS01530	COG1253	flavin adenine dinucleotide binding
HN015_RS01535	COG4989	oxidoreductase activity
HN015_RS01550	COG1737	Transcriptional regulator
HN015_RS01555	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HN015_RS01555	COG1263	PTS System
HN015_RS01560	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HN015_RS01565	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HN015_RS01570	COG2188	Transcriptional regulator
HN015_RS01575	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
HN015_RS01580	COG1051	belongs to the nudix hydrolase family
HN015_RS01585	COG0564	pseudouridine synthase activity
HN015_RS01595	COG1940	carbohydrate kinase activity
HN015_RS01600	COG1811	Na channel or pump
HN015_RS01605	COG0583	DNA-binding transcription factor activity
HN015_RS01610	COG2084	Dehydrogenase
HN015_RS01620	COG1376	ErfK ybiS ycfS ynhG family protein
HN015_RS01630	COG0586	Pfam SNARE associated Golgi protein
HN015_RS01650	COG0025	NhaP-type Na H and K H
HN015_RS01660	COG0492	ferredoxin-NADP+ reductase activity
HN015_RS01665	COG1368	sulfuric ester hydrolase activity
HN015_RS01690	COG0861	Integral membrane protein TerC family
HN015_RS01695	COG3118	belongs to the thioredoxin family
HN015_RS01715	COG0488	(ABC) transporter
HN015_RS01720	COG0656	L-ascorbic acid biosynthetic process
HN015_RS01725	COG2267	carboxylic ester hydrolase activity
HN015_RS01735	COG2936	dipeptidyl-peptidase activity
HN015_RS01740	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HN015_RS01750	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HN015_RS01755	COG0531	amino acid
HN015_RS01770	COG0194	GDP metabolic process
HN015_RS01775	COG0735	belongs to the Fur family
HN015_RS01795	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HN015_RS01800	COG0765	amino acid transport
HN015_RS01805	COG0765	amino acid transport
HN015_RS01810	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HN015_RS01815	COG0406	alpha-ribazole phosphatase activity
HN015_RS01820	COG0531	amino acid
HN015_RS01825	COG0588	phosphoglycerate mutase activity
HN015_RS01830	COG3973	AAA domain
HN015_RS01835	COG0028	Belongs to the TPP enzyme family
HN015_RS01840	COG3527	Alpha-acetolactate decarboxylase
HN015_RS01845	COG1072	(Pantothenic acid kinase))
HN015_RS01855	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HN015_RS01875	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HN015_RS01875	COG0519	Catalyzes the synthesis of GMP from XMP
HN015_RS01885	COG0477	Major facilitator Superfamily
HN015_RS01890	COG0308	aminopeptidase N
HN015_RS01900	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
HN015_RS01905	COG1518	maintenance of DNA repeat elements
HN015_RS01925	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HN015_RS01930	COG0459	protein refolding
HN015_RS01935	COG0531	amino acid
HN015_RS01940	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HN015_RS01945	COG1739	Uncharacterized protein family UPF0029
HN015_RS01950	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HN015_RS01965	COG0653	protein targeting
HN015_RS01975	COG0745	RESPONSE REGULATOR receiver
HN015_RS01980	COG5002	protein histidine kinase activity
HN015_RS01990	COG0573	inorganic phosphate transmembrane transporter activity
HN015_RS01995	COG0581	inorganic phosphate transmembrane transporter activity
HN015_RS02005	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HN015_RS02010	COG0704	Plays a role in the regulation of phosphate uptake
HN015_RS02020	COG1950	PFAM Membrane protein of
HN015_RS02025	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HN015_RS02030	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HN015_RS02035	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HN015_RS02045	COG0492	ferredoxin-NADP+ reductase activity
HN015_RS02050	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HN015_RS02060	COG0556	nucleotide-excision repair
HN015_RS02065	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HN015_RS02070	COG1660	Displays ATPase and GTPase activities
HN015_RS02075	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HN015_RS02080	COG1481	regulation of sporulation
HN015_RS02085	COG1388	LysM domain
HN015_RS02085	COG1705	Flagellar rod assembly protein muramidase FlgJ
HN015_RS02095	COG0740	serine-type endopeptidase activity
HN015_RS02105	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HN015_RS02110	COG2390	Transcriptional regulator
HN015_RS02120	COG0126	phosphoglycerate kinase activity
HN015_RS02125	COG0149	triose-phosphate isomerase activity
HN015_RS02130	COG0148	phosphopyruvate hydratase activity
HN015_RS02135	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HN015_RS02140	COG0557	exoribonuclease II activity
HN015_RS02145	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HN015_RS02160	COG0561	phosphatase activity
HN015_RS02165	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HN015_RS02170	COG0802	atpase or kinase
HN015_RS02175	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HN015_RS02190	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HN015_RS02195	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HN015_RS02205	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HN015_RS02210	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HN015_RS02230	COG1011	Hydrolase
HN015_RS02240	COG2188	Transcriptional regulator
HN015_RS02250	COG3715	PTS system
HN015_RS02255	COG3716	PTS system mannose fructose sorbose family IID component
HN015_RS02265	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HN015_RS02275	COG3479	Phenolic acid decarboxylase
HN015_RS02280	COG1695	Transcriptional regulator
HN015_RS02285	COG1028	Short-chain dehydrogenase reductase Sdr
HN015_RS02300	COG4690	dipeptidase activity
HN015_RS02305	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HN015_RS02315	COG1122	ATPase activity
HN015_RS02345	COG1131	(ABC) transporter
HN015_RS02350	COG1328	CTP reductase activity
HN015_RS02355	COG0602	queuosine metabolic process
HN015_RS02360	COG0396	ATPase activity
HN015_RS02365	COG0719	Fe-S assembly protein
HN015_RS02370	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HN015_RS02375	COG0822	iron-sulfur transferase activity
HN015_RS02380	COG0719	Fe-S assembly protein
HN015_RS02385	COG2095	MarC family integral membrane protein
HN015_RS02390	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HN015_RS02400	COG1694	Mazg nucleotide pyrophosphohydrolase
HN015_RS02405	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HN015_RS02415	COG1063	alcohol dehydrogenase
HN015_RS02440	COG5039	Polysaccharide pyruvyl transferase
HN015_RS02445	COG2814	Major facilitator Superfamily
HN015_RS02450	COG2261	transglycosylase associated protein
HN015_RS02460	COG1442	glycosyl transferase family 8
HN015_RS02485	COG2801	Transposase and inactivated derivatives
HN015_RS02555	COG3475	LICD family
HN015_RS02565	COG3397	chitin binding
HN015_RS02575	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HN015_RS02580	COG0351	phosphomethylpyrimidine kinase
HN015_RS02585	COG0352	thiamine-phosphate diphosphorylase activity
HN015_RS02595	COG0514	ATP-dependent DNA helicase (RecQ)
HN015_RS02600	COG5549	protein import
HN015_RS02600	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HN015_RS02605	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HN015_RS02620	COG0489	protein tyrosine kinase activity
HN015_RS02625	COG4464	protein tyrosine phosphatase activity
HN015_RS02630	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HN015_RS02640	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HN015_RS02660	COG0562	UDP-galactopyranose mutase
HN015_RS02680	COG2188	Transcriptional regulator
HN015_RS02690	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HN015_RS02695	COG3715	PTS system
HN015_RS02700	COG3716	PTS system mannose fructose sorbose family IID component
HN015_RS02705	COG2222	sugar isomerase
HN015_RS02745	COG2217	Heavy metal translocating P-type atpase
HN015_RS02750	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HN015_RS02765	COG0531	amino acid
HN015_RS02780	COG0673	inositol 2-dehydrogenase activity
HN015_RS02785	COG0513	Belongs to the DEAD box helicase family
HN015_RS02790	COG1316	TRANSCRIPTIONal
HN015_RS02810	COG0516	GMP reductase activity
HN015_RS02815	COG0542	response to heat
HN015_RS02835	COG0596	Alpha beta hydrolase
HN015_RS02840	COG0438	transferase activity, transferring glycosyl groups
HN015_RS02845	COG0438	transferase activity, transferring glycosyl groups
HN015_RS02980	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HN015_RS02985	COG0477	Major facilitator Superfamily
HN015_RS02990	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HN015_RS02995	COG0671	phosphoesterase, PA-phosphatase related
HN015_RS03000	COG0495	leucyl-tRNA aminoacylation
HN015_RS03005	COG2244	polysaccharide biosynthetic process
HN015_RS03010	COG1187	pseudouridine synthase activity
HN015_RS03015	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HN015_RS03020	COG0589	response to stress
HN015_RS03035	COG0154	amidase activity
HN015_RS03040	COG0366	Alpha amylase catalytic
HN015_RS03045	COG2188	Transcriptional regulator
HN015_RS03050	COG1263	PTS System
HN015_RS03050	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HN015_RS03050	COG2190	(PTS) system
HN015_RS03055	COG1428	Deoxynucleoside kinase
HN015_RS03080	COG0367	asparagine synthase
HN015_RS03085	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HN015_RS03095	COG1794	racemase activity, acting on amino acids and derivatives
HN015_RS03105	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HN015_RS03110	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
HN015_RS03115	COG0582	viral genome integration into host DNA
HN015_RS03140	COG1396	sequence-specific DNA binding
HN015_RS03190	COG0629	single-stranded DNA binding
HN015_RS03215	COG1484	DNA-dependent DNA replication
HN015_RS03385	COG1940	carbohydrate kinase activity
HN015_RS03395	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HN015_RS03400	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HN015_RS03435	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HN015_RS03440	COG1940	carbohydrate kinase activity
HN015_RS03445	COG2723	6-phospho-beta-galactosidase activity
HN015_RS03475	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HN015_RS03475	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HN015_RS03475	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HN015_RS03495	COG2017	converts alpha-aldose to the beta-anomer
HN015_RS03520	COG2160	L-arabinose isomerase activity
HN015_RS03535	COG0531	amino acid
HN015_RS03540	COG1297	OPT oligopeptide transporter protein
HN015_RS03575	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HN015_RS03600	COG1070	Carbohydrate kinase
HN015_RS03605	COG2814	Major facilitator Superfamily
HN015_RS03620	COG0446	pyridine nucleotide-disulphide oxidoreductase
HN015_RS03630	COG1937	Protein conserved in bacteria
HN015_RS03655	COG1609	Transcriptional regulator
HN015_RS03660	COG2017	converts alpha-aldose to the beta-anomer
HN015_RS03665	COG2211	Major facilitator Superfamily
HN015_RS03665	COG2190	(PTS) system
HN015_RS03680	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HN015_RS03685	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HN015_RS03690	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
HN015_RS03700	COG0531	amino acid
HN015_RS03730	COG0667	Aldo Keto reductase
HN015_RS03735	COG0018	arginyl-trna synthetase
HN015_RS03745	COG1438	arginine binding
HN015_RS03750	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HN015_RS03755	COG3679	Belongs to the UPF0342 family
HN015_RS03760	COG0420	3'-5' exonuclease activity
HN015_RS03765	COG4717	serine-type aminopeptidase activity
HN015_RS03775	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HN015_RS03785	COG0537	adenosine 5'-monophosphoramidase activity
HN015_RS03790	COG1131	(ABC) transporter
HN015_RS03795	COG4473	ABC transporter
HN015_RS03800	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HN015_RS03810	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HN015_RS03815	COG1674	ftsk spoiiie
HN015_RS03820	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HN015_RS03825	COG0670	Belongs to the BI1 family
HN015_RS03830	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HN015_RS03830	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HN015_RS03835	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HN015_RS03845	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HN015_RS03855	COG1484	DNA-dependent DNA replication
HN015_RS03860	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HN015_RS03865	COG3275	phosphorelay sensor kinase activity
HN015_RS03870	COG3279	Response regulator of the LytR AlgR family
HN015_RS03880	COG1346	cytolysis
HN015_RS03885	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HN015_RS03890	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HN015_RS03895	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HN015_RS03900	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HN015_RS03905	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HN015_RS03910	COG1534	Rna-binding protein
HN015_RS03915	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HN015_RS03920	COG1713	HD superfamily hydrolase involved in NAD metabolism
HN015_RS03925	COG0799	negative regulation of ribosome biogenesis
HN015_RS03930	COG2226	methyltransferase
HN015_RS03935	COG1323	Belongs to the UPF0348 family
HN015_RS03940	COG1399	metal-binding, possibly nucleic acid-binding protein
HN015_RS03945	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HN015_RS03950	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HN015_RS03955	COG0745	RESPONSE REGULATOR receiver
HN015_RS03960	COG5002	protein histidine kinase activity
HN015_RS03965	COG2814	Major facilitator Superfamily
HN015_RS03970	COG3119	arylsulfatase activity
HN015_RS03970	COG3408	Glycogen debranching enzyme
HN015_RS03975	COG0706	membrane insertase activity
HN015_RS03980	COG1254	Belongs to the acylphosphatase family
HN015_RS03985	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HN015_RS03995	COG1733	regulation of RNA biosynthetic process
HN015_RS04000	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HN015_RS04005	COG0072	phenylalanine-tRNA ligase activity
HN015_RS04005	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HN015_RS04010	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HN015_RS04015	COG0572	uridine kinase
HN015_RS04020	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HN015_RS04025	COG4485	Bacterial membrane protein, YfhO
HN015_RS04035	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HN015_RS04040	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HN015_RS04045	COG0705	Rhomboid family
HN015_RS04055	COG1940	carbohydrate kinase activity
HN015_RS04060	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HN015_RS04070	COG0584	glycerophosphoryl diester phosphodiesterase
HN015_RS04075	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HN015_RS04080	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
HN015_RS04085	COG0789	Transcriptional regulator
HN015_RS04130	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HN015_RS04140	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HN015_RS04145	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HN015_RS04150	COG1302	Protein conserved in bacteria
HN015_RS04155	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HN015_RS04160	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HN015_RS04165	COG1570	exodeoxyribonuclease VII activity
HN015_RS04170	COG1722	exodeoxyribonuclease VII activity
HN015_RS04180	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HN015_RS04185	COG1438	arginine binding
HN015_RS04190	COG0497	DNA recombination
HN015_RS04205	COG1758	RNA polymerase activity
HN015_RS04210	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HN015_RS04215	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HN015_RS04220	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HN015_RS04225	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HN015_RS04225	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HN015_RS04235	COG0515	serine threonine protein kinase
HN015_RS04235	COG2815	serine threonine protein kinase
HN015_RS04240	COG1162	GTPase activity
HN015_RS04245	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HN015_RS04255	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HN015_RS04270	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HN015_RS04275	COG0416	fatty acid biosynthetic process
HN015_RS04280	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HN015_RS04285	COG0571	ribonuclease III activity
HN015_RS04290	COG1196	nuclear chromosome segregation
HN015_RS04295	COG0552	protein localization to endoplasmic reticulum
HN015_RS04300	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
HN015_RS04305	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HN015_RS04310	COG0228	four-way junction DNA binding
HN015_RS04315	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HN015_RS04320	COG0336	Belongs to the RNA methyltransferase TrmD family
HN015_RS04325	COG4619	ABC transporter
HN015_RS04330	COG0390	transport system, permease component
HN015_RS04335	COG0335	large ribosomal subunit rRNA binding
HN015_RS04355	COG0393	Putative heavy-metal-binding
HN015_RS04365	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HN015_RS04370	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HN015_RS04380	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HN015_RS04385	COG1028	Short-chain dehydrogenase reductase Sdr
HN015_RS04390	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HN015_RS04395	COG0511	ligase activity, forming carbon-carbon bonds
HN015_RS04405	COG0439	Biotin carboxylase
HN015_RS04410	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HN015_RS04415	COG0825	malonyl-CoA metabolic process
HN015_RS04420	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HN015_RS04425	COG4974	Belongs to the 'phage' integrase family
HN015_RS04460	COG1396	sequence-specific DNA binding
HN015_RS04545	COG0629	single-stranded DNA binding
HN015_RS04590	COG3425	synthase
HN015_RS04600	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HN015_RS04605	COG4224	UPF0291 protein
HN015_RS04610	COG3763	UPF0154 protein
HN015_RS04615	COG0204	Acyl-transferase
HN015_RS04620	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HN015_RS04640	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HN015_RS04645	COG0528	UMP kinase activity
HN015_RS04650	COG0233	cytoplasmic translational termination
HN015_RS04655	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HN015_RS04660	COG4589	Belongs to the CDS family
HN015_RS04665	COG0750	zinc metalloprotease
HN015_RS04670	COG0442	prolyl-tRNA aminoacylation
HN015_RS04675	COG2176	DNA-directed DNA polymerase activity
HN015_RS04680	COG0779	Required for maturation of 30S ribosomal subunits
HN015_RS04685	COG0195	Participates in both transcription termination and antitermination
HN015_RS04690	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HN015_RS04700	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HN015_RS04705	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HN015_RS04710	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HN015_RS04715	COG0196	riboflavin kinase activity
HN015_RS04720	COG1420	regulation of RNA biosynthetic process
HN015_RS04725	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HN015_RS04730	COG0443	Heat shock 70 kDa protein
HN015_RS04735	COG0484	heat shock protein binding
HN015_RS04740	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
HN015_RS04745	COG2155	Conserved Protein
HN015_RS04755	COG1131	(ABC) transporter
HN015_RS04770	COG0583	DNA-binding transcription factor activity
HN015_RS04780	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HN015_RS04785	COG4708	membrane
HN015_RS04810	COG0531	amino acid
HN015_RS04815	COG3250	beta-galactosidase activity
HN015_RS04840	COG1942	4-Oxalocrotonate Tautomerase
HN015_RS04845	COG0561	phosphatase activity
HN015_RS04850	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
HN015_RS04850	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HN015_RS04855	COG1304	FMN binding
HN015_RS04875	COG1199	ATP-dependent helicase activity
HN015_RS04875	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HN015_RS04885	COG3935	DnaD domain protein
HN015_RS04890	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HN015_RS04895	COG3331	DNA recombination
HN015_RS04900	COG4474	Belongs to the UPF0398 family
HN015_RS04905	COG3599	regulation of cell shape
HN015_RS04915	COG0116	Belongs to the methyltransferase superfamily
HN015_RS04920	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HN015_RS04930	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HN015_RS04940	COG0564	pseudouridine synthase activity
HN015_RS04945	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HN015_RS04955	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HN015_RS04960	COG1293	RNA-binding protein homologous to eukaryotic snRNP
HN015_RS04970	COG1307	EDD domain protein, DegV family
HN015_RS04980	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HN015_RS04990	COG1609	Transcriptional regulator
HN015_RS05000	COG1288	antiporter activity
HN015_RS05005	COG1316	TRANSCRIPTIONal
HN015_RS05010	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HN015_RS05015	COG2814	Major facilitator Superfamily
HN015_RS05025	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HN015_RS05030	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HN015_RS05030	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HN015_RS05040	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HN015_RS05040	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HN015_RS05045	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HN015_RS05050	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HN015_RS05055	COG0285	dihydrofolate synthase activity
HN015_RS05060	COG0302	gtp cyclohydrolase
HN015_RS05065	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HN015_RS05065	COG0302	gtp cyclohydrolase
HN015_RS05085	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HN015_RS05090	COG1929	Belongs to the glycerate kinase type-1 family
HN015_RS05095	COG2610	gluconate transmembrane transporter activity
HN015_RS05100	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HN015_RS05105	COG1227	inorganic diphosphatase activity
HN015_RS05110	COG0583	DNA-binding transcription factor activity
HN015_RS05115	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HN015_RS05120	COG0187	DNA topoisomerase II activity
HN015_RS05135	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HN015_RS05140	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HN015_RS05145	COG4974	Belongs to the 'phage' integrase family
HN015_RS05150	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HN015_RS05155	COG0758	DNA mediated transformation
HN015_RS05160	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HN015_RS05200	COG2207	Transcriptional regulator
HN015_RS05205	COG0457	Tetratricopeptide repeat
HN015_RS05210	COG2017	converts alpha-aldose to the beta-anomer
HN015_RS05215	COG2190	(PTS) system
HN015_RS05215	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HN015_RS05215	COG1263	PTS System
HN015_RS05220	COG0446	pyridine nucleotide-disulphide oxidoreductase
HN015_RS05225	COG0183	Belongs to the thiolase family
HN015_RS05245	COG1131	(ABC) transporter
HN015_RS05275	COG1309	transcriptional regulator
HN015_RS05280	COG0151	Belongs to the GarS family
HN015_RS05285	COG0138	bifunctional purine biosynthesis protein purh
HN015_RS05290	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HN015_RS05295	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HN015_RS05305	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HN015_RS05310	COG0047	phosphoribosylformylglycinamidine synthase activity
HN015_RS05315	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HN015_RS05320	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HN015_RS05325	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HN015_RS05330	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HN015_RS05355	COG1131	(ABC) transporter
HN015_RS05360	COG1395	domain, Protein
HN015_RS05370	COG3279	Response regulator of the LytR AlgR family
HN015_RS05380	COG1132	(ABC) transporter
HN015_RS05385	COG1131	(ABC) transporter
HN015_RS05410	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HN015_RS05415	COG2022	thiamine diphosphate biosynthetic process
HN015_RS05420	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HN015_RS05425	COG1301	dicarboxylic acid transport
HN015_RS05430	COG0105	UTP biosynthetic process
HN015_RS05480	COG2723	6-phospho-beta-galactosidase activity
HN015_RS05485	COG2190	(PTS) system
HN015_RS05485	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HN015_RS05485	COG1263	PTS System
HN015_RS05505	COG0531	amino acid
HN015_RS05510	COG1393	Belongs to the ArsC family
HN015_RS05515	COG3409	Peptidoglycan-binding domain 1 protein
HN015_RS05515	COG0793	Belongs to the peptidase S41A family
HN015_RS05520	COG4479	Belongs to the UPF0346 family
HN015_RS05530	COG2755	lipolytic protein G-D-S-L family
HN015_RS05535	COG1307	EDD domain protein, DegV family
HN015_RS05540	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HN015_RS05545	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HN015_RS05550	COG0488	(ABC) transporter
HN015_RS05555	COG0617	tRNA 3'-terminal CCA addition
HN015_RS05560	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HN015_RS05575	COG0457	Tetratricopeptide repeat
HN015_RS05585	COG1160	GTP binding
HN015_RS05590	COG0539	negative regulation of cytoplasmic translation
HN015_RS05595	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HN015_RS05605	COG0514	ATP-dependent DNA helicase (RecQ)
HN015_RS05615	COG1187	pseudouridine synthase activity
HN015_RS05620	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HN015_RS05625	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HN015_RS05645	COG2707	UPF0756 membrane protein
HN015_RS05655	COG0205	6-phosphofructokinase activity
HN015_RS05660	COG0587	DNA-directed DNA polymerase activity
HN015_RS05670	COG0542	response to heat
HN015_RS05675	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HN015_RS05680	COG2384	SAM-dependent methyltransferase
HN015_RS05685	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HN015_RS05690	COG0358	DNA primase activity
HN015_RS05695	COG0751	glycine-tRNA ligase activity
HN015_RS05700	COG0752	glycyl-tRNA synthetase alpha subunit
HN015_RS05705	COG1381	Involved in DNA repair and RecF pathway recombination
HN015_RS05710	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HN015_RS05720	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HN015_RS05725	COG1702	phosphate starvation-inducible protein PhoH
HN015_RS05735	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HN015_RS05740	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HN015_RS05750	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HN015_RS05755	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HN015_RS05770	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HN015_RS05775	COG0124	histidyl-tRNA synthetase
HN015_RS05785	COG0546	phosphoglycolate phosphatase activity
HN015_RS05790	COG1490	D-aminoacyl-tRNA deacylase activity
HN015_RS05795	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HN015_RS05805	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HN015_RS05810	COG2264	protein methyltransferase activity
HN015_RS05815	COG2233	PERMEase
HN015_RS05835	COG0436	Aminotransferase
HN015_RS05840	COG1088	dTDP-glucose 4,6-dehydratase activity
HN015_RS05850	COG2153	protein acetylation
HN015_RS05855	COG1132	(ABC) transporter
HN015_RS05865	COG0778	Nitroreductase
HN015_RS05890	COG1304	FMN binding
HN015_RS05910	COG2261	transglycosylase associated protein
HN015_RS05925	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HN015_RS05950	COG1131	(ABC) transporter
HN015_RS05965	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HN015_RS05970	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HN015_RS05970	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HN015_RS05975	COG0300	oxidoreductase activity
HN015_RS05980	COG1234	tRNA 3'-trailer cleavage
HN015_RS05990	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HN015_RS05995	COG0322	excinuclease ABC activity
HN015_RS06000	COG1126	abc transporter atp-binding protein
HN015_RS06005	COG0765	amino acid transport
HN015_RS06020	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HN015_RS06025	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HN015_RS06030	COG0544	peptidyl-prolyl cis-trans isomerase activity
HN015_RS06035	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HN015_RS06050	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HN015_RS06055	COG0268	Binds directly to 16S ribosomal RNA
HN015_RS06070	COG2131	deaminase
HN015_RS06075	COG1596	polysaccharide export
HN015_RS06075	COG1555	photosystem II stabilization
HN015_RS06080	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HN015_RS06085	COG0742	ribosomal rna small subunit methyltransferase
HN015_RS06090	COG4471	UPF0298 protein
HN015_RS06095	COG0772	Belongs to the SEDS family
HN015_RS06105	COG0483	inositol monophosphate 1-phosphatase activity
HN015_RS06110	COG4476	Belongs to the UPF0223 family
HN015_RS06115	COG0242	peptide deformylase activity
HN015_RS06140	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HN015_RS06140	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HN015_RS06140	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HN015_RS06145	COG1105	Belongs to the carbohydrate kinase PfkB family
HN015_RS06150	COG1349	DNA-binding transcription factor activity
HN015_RS06155	COG0628	permease
HN015_RS06160	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HN015_RS06165	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HN015_RS06180	COG0482	sulfurtransferase activity
HN015_RS06190	COG1104	cysteine desulfurase activity
HN015_RS06195	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HN015_RS06205	COG0494	nUDIX hydrolase
HN015_RS06210	COG1278	Cold shock
HN015_RS06215	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HN015_RS06220	COG3599	regulation of cell shape
HN015_RS06225	COG2302	S4 RNA-binding domain
HN015_RS06240	COG0849	cell division
HN015_RS06245	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HN015_RS06250	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HN015_RS06255	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HN015_RS06260	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HN015_RS06275	COG0275	rRNA processing
HN015_RS06280	COG2001	Belongs to the MraZ family
HN015_RS06290	COG1674	ftsk spoiiie
HN015_RS06300	COG0628	permease
HN015_RS06310	COG2706	6-phosphogluconolactonase activity
HN015_RS06315	COG3142	Participates in the control of copper homeostasis
HN015_RS06320	COG2239	Acts as a magnesium transporter
HN015_RS06325	COG0564	pseudouridine synthase activity
HN015_RS06330	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HN015_RS06335	COG2357	RelA SpoT domain protein
HN015_RS06350	COG4862	establishment of competence for transformation
HN015_RS06355	COG1393	Belongs to the ArsC family
HN015_RS06360	COG1234	tRNA 3'-trailer cleavage
HN015_RS06435	COG1185	polyribonucleotide nucleotidyltransferase activity
HN015_RS06440	COG0586	Pfam SNARE associated Golgi protein
HN015_RS06450	COG0647	UMP catabolic process
HN015_RS06455	COG4470	Protein conserved in bacteria
HN015_RS06465	COG0827	DNA restriction-modification system
HN015_RS06490	COG4537	Required for transformation and DNA binding
HN015_RS06495	COG1459	type II secretion system
HN015_RS06500	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HN015_RS06510	COG0217	transcriptional regulatory protein
HN015_RS06515	COG2132	Multicopper oxidase
HN015_RS06525	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HN015_RS06530	COG1335	isochorismatase
HN015_RS06535	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HN015_RS06540	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HN015_RS06545	COG1028	Short-chain dehydrogenase reductase Sdr
HN015_RS06550	COG0656	L-ascorbic acid biosynthetic process
HN015_RS06555	COG1733	regulation of RNA biosynthetic process
HN015_RS06565	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HN015_RS06570	COG1609	Transcriptional regulator
HN015_RS06575	COG0006	proline dipeptidase activity
HN015_RS06590	COG0668	transmembrane transport
HN015_RS06595	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HN015_RS06600	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HN015_RS06605	COG0574	Belongs to the PEP-utilizing enzyme family
HN015_RS06605	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HN015_RS06610	COG3118	belongs to the thioredoxin family
HN015_RS06615	COG1193	negative regulation of DNA recombination
HN015_RS06620	COG3906	Belongs to the UPF0473 family
HN015_RS06625	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HN015_RS06630	COG4472	Bacterial protein of unknown function (DUF965)
HN015_RS06635	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HN015_RS06640	COG0513	Belongs to the DEAD box helicase family
HN015_RS06650	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HN015_RS06655	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HN015_RS06660	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HN015_RS06665	COG1862	Preprotein translocase
HN015_RS06670	COG0343	queuine tRNA-ribosyltransferase activity
HN015_RS06675	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HN015_RS06680	COG2255	four-way junction helicase activity
HN015_RS06685	COG0632	four-way junction helicase activity
HN015_RS06690	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HN015_RS06695	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HN015_RS06700	COG1418	mRNA catabolic process
HN015_RS06710	COG1058	Belongs to the CinA family
HN015_RS06710	COG1546	Belongs to the CinA family
HN015_RS06715	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HN015_RS06725	COG0300	oxidoreductase activity
HN015_RS06730	COG0612	Peptidase, M16
HN015_RS06735	COG0612	Peptidase, M16
HN015_RS06740	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HN015_RS06745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HN015_RS06750	COG1126	abc transporter atp-binding protein
HN015_RS06755	COG0765	amino acid transport
HN015_RS06770	COG2003	Belongs to the UPF0758 family
HN015_RS06775	COG0285	dihydrofolate synthase activity
HN015_RS06780	COG0525	valine-tRNA ligase activity
HN015_RS06790	COG0301	tRNA thio-modification
HN015_RS06795	COG1104	cysteine desulfurase activity
HN015_RS06800	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
HN015_RS06805	COG1956	GAF domain-containing protein
HN015_RS06810	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HN015_RS06815	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HN015_RS06830	COG0589	response to stress
HN015_RS06840	COG1181	Belongs to the D-alanine--D-alanine ligase family
HN015_RS06850	COG0531	amino acid
HN015_RS06865	COG1131	(ABC) transporter
HN015_RS06870	COG1725	Transcriptional regulator
HN015_RS06875	COG1464	Belongs to the NlpA lipoprotein family
HN015_RS06880	COG2011	ABC-type metal ion transport system permease component
HN015_RS06885	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HN015_RS06890	COG0772	Belongs to the SEDS family
HN015_RS06900	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HN015_RS06905	COG4836	Membrane
HN015_RS06910	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HN015_RS06915	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HN015_RS06920	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HN015_RS06925	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HN015_RS06930	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HN015_RS06935	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HN015_RS06940	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HN015_RS06945	COG0356	it plays a direct role in the translocation of protons across the membrane
HN015_RS06960	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HN015_RS06965	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HN015_RS06970	COG0009	L-threonylcarbamoyladenylate synthase
HN015_RS06975	COG2890	protein-(glutamine-N5) methyltransferase activity
HN015_RS06985	COG1435	thymidine kinase activity
HN015_RS06990	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HN015_RS06995	COG3442	glutamine amidotransferase
HN015_RS07000	COG1482	cell wall glycoprotein biosynthetic process
HN015_RS07010	COG1132	(ABC) transporter
HN015_RS07030	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HN015_RS07050	COG3976	FMN-binding domain protein
HN015_RS07050	COG1053	succinate dehydrogenase
HN015_RS07050	COG0431	NADPH-dependent FMN reductase
HN015_RS07055	COG0431	NADPH-dependent FMN reductase
HN015_RS07055	COG3976	FMN-binding domain protein
HN015_RS07055	COG1053	succinate dehydrogenase
HN015_RS07065	COG0166	Belongs to the GPI family
HN015_RS07070	COG4975	Glucose uptake
HN015_RS07080	COG3850	Histidine kinase
HN015_RS07080	COG5002	protein histidine kinase activity
HN015_RS07085	COG0745	RESPONSE REGULATOR receiver
HN015_RS07100	COG0741	lytic transglycosylase activity
HN015_RS07110	COG2610	gluconate transmembrane transporter activity
HN015_RS07115	COG1070	Carbohydrate kinase
HN015_RS07120	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HN015_RS07125	COG1737	Transcriptional regulator
HN015_RS07140	COG0438	transferase activity, transferring glycosyl groups
HN015_RS07150	COG1073	alpha beta
HN015_RS07160	COG0201	protein transport
HN015_RS07165	COG0653	protein targeting
HN015_RS07180	COG0730	response to heat
HN015_RS07185	COG1368	sulfuric ester hydrolase activity
HN015_RS07190	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HN015_RS07195	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HN015_RS07200	COG0628	permease
HN015_RS07205	COG3557	Belongs to the UPF0374 family
HN015_RS07210	COG2137	regulation of response to DNA damage stimulus
HN015_RS07215	COG0716	FMN binding
HN015_RS07240	COG4974	Belongs to the 'phage' integrase family
HN015_RS07255	COG0732	type I restriction modification DNA specificity domain
HN015_RS07305	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HN015_RS07305	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HN015_RS07360	COG1802	Transcriptional regulator
HN015_RS07360	COG4626	Terminase
HN015_RS07375	COG4695	Portal protein
HN015_RS07430	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HN015_RS07435	COG1597	lipid kinase activity
HN015_RS07440	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HN015_RS07445	COG0154	amidase activity
HN015_RS07455	COG4851	CamS sex pheromone cAM373 precursor
HN015_RS07465	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HN015_RS07470	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HN015_RS07475	COG1705	Flagellar rod assembly protein muramidase FlgJ
HN015_RS07510	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HN015_RS07525	COG0531	amino acid
HN015_RS07550	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HN015_RS07555	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HN015_RS07570	COG1122	ATPase activity
HN015_RS07575	COG1122	ATPase activity
HN015_RS07580	COG0203	ribosomal protein L17
HN015_RS07585	COG0202	RNA polymerase activity
HN015_RS07590	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HN015_RS07595	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HN015_RS07600	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HN015_RS07605	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HN015_RS07620	COG0200	Binds to the 23S rRNA
HN015_RS07625	COG1841	ribosomal large subunit assembly
HN015_RS07630	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HN015_RS07635	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HN015_RS07640	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HN015_RS07645	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HN015_RS07650	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HN015_RS07655	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HN015_RS07660	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HN015_RS07665	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HN015_RS07675	COG0255	Belongs to the universal ribosomal protein uL29 family
HN015_RS07680	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HN015_RS07685	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HN015_RS07690	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HN015_RS07695	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HN015_RS07700	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HN015_RS07705	COG0089	rRNA binding
HN015_RS07710	COG0088	Forms part of the polypeptide exit tunnel
HN015_RS07715	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HN015_RS07720	COG0051	transcription antitermination factor activity, RNA binding
HN015_RS07725	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HN015_RS07730	COG0049	tRNA binding
HN015_RS07735	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HN015_RS07745	COG1957	nucleoside hydrolase
HN015_RS07750	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HN015_RS07755	COG0085	RNA polymerase activity
HN015_RS07760	COG0542	response to heat
HN015_RS07765	COG4463	regulation of RNA biosynthetic process
HN015_RS07770	COG0028	Belongs to the TPP enzyme family
HN015_RS07810	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HN015_RS07815	COG1428	Deoxynucleoside kinase
HN015_RS07820	COG0833	amino acid
HN015_RS07835	COG1316	TRANSCRIPTIONal
HN015_RS07845	COG2966	Psort location CytoplasmicMembrane, score
HN015_RS07850	COG1278	Cold shock
HN015_RS07855	COG1230	cation diffusion facilitator family transporter
HN015_RS07865	COG1418	mRNA catabolic process
HN015_RS07870	COG1418	mRNA catabolic process
HN015_RS07880	COG0564	pseudouridine synthase activity
HN015_RS07900	COG4690	dipeptidase activity
HN015_RS07910	COG4152	abc transporter atp-binding protein
HN015_RS07915	COG1476	TRANSCRIPTIONal
HN015_RS07920	COG4932	domain protein
HN015_RS07920	COG4886	Leucine-rich repeat (LRR) protein
HN015_RS07940	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HN015_RS07950	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HN015_RS07960	COG1214	PFAM Peptidase M22, glycoprotease
HN015_RS07965	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HN015_RS07980	COG4467	Involved in initiation control of chromosome replication
HN015_RS07985	COG0470	DNA polymerase III
HN015_RS07990	COG3870	Protein conserved in bacteria
HN015_RS07995	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HN015_RS08000	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HN015_RS08005	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HN015_RS08010	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HN015_RS08025	COG2813	Specifically methylates the guanine in position
HN015_RS08030	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HN015_RS08035	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HN015_RS08040	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HN015_RS08045	COG0222	ribosome binding
HN015_RS08050	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HN015_RS08055	COG0081	regulation of translation
HN015_RS08065	COG0250	Participates in transcription elongation, termination and antitermination
HN015_RS08075	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HN015_RS08085	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HN015_RS08090	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HN015_RS08095	COG0215	cysteine-tRNA ligase activity
HN015_RS08100	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HN015_RS08105	COG4956	integral membrane protein (PIN domain superfamily)
HN015_RS08110	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HN015_RS08125	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HN015_RS08135	COG0588	phosphoglycerate mutase activity
HN015_RS08140	COG0825	malonyl-CoA metabolic process
HN015_RS08150	COG0439	Biotin carboxylase
HN015_RS08160	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HN015_RS08175	COG3933	PFAM sigma-54 factor interaction domain-containing protein
HN015_RS08175	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HN015_RS08185	COG3716	PTS system mannose fructose sorbose family IID component
HN015_RS08190	COG3715	PTS system
HN015_RS08205	COG3091	SprT-like family
HN015_RS08210	COG2183	response to ionizing radiation
HN015_RS08230	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HN015_RS08235	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HN015_RS08240	COG2188	Transcriptional regulator
HN015_RS08250	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HN015_RS08255	COG1064	alcohol dehydrogenase
HN015_RS08275	COG3104	oligopeptide transport
HN015_RS08315	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HN015_RS08320	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HN015_RS08325	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HN015_RS08340	COG0037	tRNA processing
HN015_RS08345	COG1098	S1 RNA binding domain
HN015_RS08355	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HN015_RS08360	COG2244	polysaccharide biosynthetic process
HN015_RS08365	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HN015_RS08370	COG0193	aminoacyl-tRNA hydrolase activity
HN015_RS08390	COG2337	Toxic component of a toxin-antitoxin (TA) module
HN015_RS08415	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HN015_RS08425	COG0501	Belongs to the peptidase M48B family
HN015_RS08430	COG1704	LemA family
HN015_RS08435	COG3764	Sortase (surface protein transpeptidase)
HN015_RS08445	COG0254	rRNA binding
HN015_RS08450	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HN015_RS08455	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HN015_RS08460	COG0504	CTP synthase activity
HN015_RS08465	COG3343	RNA polymerase activity
HN015_RS08475	COG1078	dGTPase activity
HN015_RS08495	COG1940	carbohydrate kinase activity
HN015_RS08525	COG0534	Mate efflux family protein
HN015_RS08540	COG0546	phosphoglycolate phosphatase activity
HN015_RS08550	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HN015_RS08555	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HN015_RS08560	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HN015_RS08565	COG1696	Membrane protein involved in D-alanine export
HN015_RS08570	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HN015_RS08580	COG1268	BioY protein
HN015_RS08590	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HN015_RS08600	COG2814	Major facilitator Superfamily
HN015_RS08610	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HN015_RS08615	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HN015_RS08625	COG0463	Glycosyl transferase, family 2
HN015_RS08635	COG1134	teichoic acid transport
HN015_RS08640	COG1682	transport, permease protein
HN015_RS08645	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HN015_RS08650	COG0463	Glycosyl transferase, family 2
HN015_RS08655	COG2246	polysaccharide biosynthetic process
HN015_RS08660	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HN015_RS08665	COG0708	Exodeoxyribonuclease III
HN015_RS08675	COG1193	negative regulation of DNA recombination
HN015_RS08680	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
HN015_RS08695	COG0114	fumarate hydratase activity
HN015_RS08705	COG0583	DNA-binding transcription factor activity
HN015_RS08715	COG0667	Aldo Keto reductase
HN015_RS08740	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HN015_RS08745	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HN015_RS08750	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HN015_RS08810	COG1164	Oligoendopeptidase f
HN015_RS08825	COG2211	Major facilitator Superfamily
HN015_RS08830	COG2814	Major facilitator Superfamily
HN015_RS08835	COG1854	S-ribosylhomocysteine lyase activity
HN015_RS08840	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HN015_RS08845	COG0110	maltose O-acetyltransferase activity
HN015_RS08850	COG0446	pyridine nucleotide-disulphide oxidoreductase
HN015_RS08865	COG0105	UTP biosynthetic process
HN015_RS08870	COG0697	spore germination
HN015_RS08880	COG0488	(ABC) transporter
HN015_RS08890	COG0402	S-adenosylhomocysteine deaminase activity
HN015_RS08895	COG1136	(ABC) transporter
HN015_RS08895	COG0577	efflux transmembrane transporter activity
HN015_RS08900	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HN015_RS08910	COG1174	glycine betaine transport
HN015_RS08915	COG1732	Glycine betaine
HN015_RS08935	COG0673	inositol 2-dehydrogenase activity
HN015_RS08940	COG1132	(ABC) transporter
HN015_RS08950	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
HN015_RS08955	COG1461	Dihydroxyacetone kinase
HN015_RS08960	COG2376	Dihydroxyacetone kinase
HN015_RS08965	COG2357	RelA SpoT domain protein
HN015_RS08975	COG2249	NAD(P)H dehydrogenase (quinone) activity
HN015_RS09005	COG2261	transglycosylase associated protein
HN015_RS09010	COG0667	Aldo Keto reductase
HN015_RS09015	COG0561	phosphatase activity
HN015_RS09020	COG0284	orotidine-5'-phosphate decarboxylase activity
HN015_RS09025	COG0242	peptide deformylase activity
HN015_RS09035	COG1846	Transcriptional regulator
HN015_RS09050	COG1131	(ABC) transporter
HN015_RS09055	COG0789	Transcriptional regulator
HN015_RS09060	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HN015_RS09080	COG4975	Glucose uptake
HN015_RS09085	COG1869	D-ribose catabolic process
HN015_RS09095	COG1609	Transcriptional regulator
HN015_RS09100	COG1914	H( )-stimulated, divalent metal cation uptake system
HN015_RS09135	COG0702	epimerase
HN015_RS09155	COG0697	spore germination
HN015_RS09160	COG0588	phosphoglycerate mutase activity
HN015_RS09165	COG0148	phosphopyruvate hydratase activity
HN015_RS09175	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HN015_RS09195	COG1686	Belongs to the peptidase S11 family
HN015_RS09200	COG5002	protein histidine kinase activity
HN015_RS09205	COG0745	RESPONSE REGULATOR receiver
HN015_RS09210	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HN015_RS09225	COG0012	GTP binding
HN015_RS09230	COG4481	Protein conserved in bacteria
HN015_RS09235	COG1475	DNA binding
HN015_RS09240	COG0357	Ribosomal RNA small subunit methyltransferase G
HN015_RS09255	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HN015_RS09265	COG0791	NLP P60 protein
HN015_RS09275	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HN015_RS09280	COG2197	response regulator
HN015_RS09285	COG4585	Histidine kinase
HN015_RS09290	COG0842	Transport permease protein
HN015_RS09300	COG0586	Pfam SNARE associated Golgi protein
HN015_RS09315	COG2755	lipolytic protein G-D-S-L family
HN015_RS09315	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HN015_RS09330	COG1136	(ABC) transporter
HN015_RS09350	COG2200	EAL domain
HN015_RS09365	COG3507	Belongs to the glycosyl hydrolase 43 family
HN015_RS09370	COG2211	Major facilitator Superfamily
HN015_RS09385	COG2115	Belongs to the xylose isomerase family
HN015_RS09400	COG2017	converts alpha-aldose to the beta-anomer
HN015_RS09420	COG2222	sugar isomerase
HN015_RS09425	COG2188	Transcriptional regulator
HN015_RS09430	COG3716	PTS system mannose fructose sorbose family IID component
HN015_RS09440	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HN015_RS09470	COG4708	membrane
HN015_RS09475	COG0604	alcohol dehydrogenase
HN015_RS09500	COG0095	Lipoate-protein ligase
HN015_RS09505	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HN015_RS09510	COG2723	6-phospho-beta-galactosidase activity
HN015_RS09515	COG2188	Transcriptional regulator
HN015_RS09525	COG1511	domain protein
HN015_RS09525	COG1511	domain protein
HN015_RS09530	COG0640	Transcriptional regulator
HN015_RS09545	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HN015_RS09550	COG1609	Transcriptional regulator
HN015_RS09565	COG3279	Response regulator of the LytR AlgR family
HN015_RS09600	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HN015_RS09610	COG1904	glucuronate isomerase
HN015_RS09620	COG2211	Major facilitator Superfamily
HN015_RS09625	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HN015_RS09630	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HN015_RS09635	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HN015_RS09655	COG0745	RESPONSE REGULATOR receiver
HN015_RS09670	COG0667	Aldo Keto reductase
HN015_RS09710	COG2188	Transcriptional regulator
HN015_RS09720	COG1064	alcohol dehydrogenase
HN015_RS09725	COG0640	Transcriptional regulator
HN015_RS09775	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HN015_RS09780	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HN015_RS09780	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HN015_RS09785	COG1609	Transcriptional regulator
HN015_RS09800	COG1970	mechanosensitive ion channel activity
HN015_RS09810	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HN015_RS09830	COG0577	efflux transmembrane transporter activity
HN015_RS09830	COG1136	(ABC) transporter
HN015_RS09850	COG2832	Protein of unknown function (DUF454)
HN015_RS09855	COG2723	6-phospho-beta-galactosidase activity
HN015_RS09865	COG3711	transcriptional antiterminator
HN015_RS09870	COG2723	6-phospho-beta-galactosidase activity
HN015_RS09885	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HN015_RS09890	COG1074	ATP-dependent DNA helicase activity
HN015_RS09895	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
HN015_RS09910	COG0519	Catalyzes the synthesis of GMP from XMP
HN015_RS09925	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HN015_RS09930	COG0537	adenosine 5'-monophosphoramidase activity
HN015_RS09940	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HN015_RS09950	COG1446	asparaginase
HN015_RS09955	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HN015_RS09960	COG2188	Transcriptional regulator
HN015_RS09965	COG3022	response to hydroperoxide
HN015_RS09970	COG0445	tRNA wobble uridine modification
HN015_RS09975	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HN015_RS09980	COG0706	membrane insertase activity
HN015_RS09985	COG0594	ribonuclease P activity
HN015_RS09990	COG0230	Belongs to the bacterial ribosomal protein bL34 family