locus-tag	class	description
S100424_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
S100424_RS00010	COG0592	DNA-directed DNA polymerase activity
S100424_RS00015	COG2501	S4 domain
S100424_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
S100424_RS00025	COG0187	DNA topoisomerase II activity
S100424_RS00035	COG0360	Binds together with S18 to 16S ribosomal RNA
S100424_RS00040	COG0629	single-stranded DNA binding
S100424_RS00045	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
S100424_RS00055	COG0359	binds to the 23S rRNA
S100424_RS00060	COG0305	Participates in initiation and elongation during chromosome replication
S100424_RS00065	COG2814	Major facilitator Superfamily
S100424_RS00080	COG0488	(ABC) transporter
S100424_RS00095	COG1136	(ABC) transporter
S100424_RS00105	COG1396	sequence-specific DNA binding
S100424_RS00110	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S100424_RS00120	COG0431	NADPH-dependent FMN reductase
S100424_RS00130	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
S100424_RS00140	COG2235	arginine
S100424_RS00170	COG0789	Transcriptional regulator
S100424_RS00175	COG2076	Multidrug Resistance protein
S100424_RS00185	COG1272	protein, Hemolysin III
S100424_RS00265	COG0583	DNA-binding transcription factor activity
S100424_RS00270	COG0110	maltose O-acetyltransferase activity
S100424_RS00275	COG4221	oxidoreductase activity
S100424_RS00300	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
S100424_RS00305	COG2188	Transcriptional regulator
S100424_RS00345	COG0656	L-ascorbic acid biosynthetic process
S100424_RS00400	COG1215	transferase activity, transferring glycosyl groups
S100424_RS00405	COG2723	6-phospho-beta-galactosidase activity
S100424_RS00430	COG0667	Aldo Keto reductase
S100424_RS00435	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
S100424_RS00445	COG3546	catalase activity
S100424_RS00480	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
S100424_RS00490	COG4932	domain protein
S100424_RS00500	COG3775	system Galactitol-specific IIC component
S100424_RS00515	COG1349	DNA-binding transcription factor activity
S100424_RS00530	COG3684	Belongs to the aldolase LacD family
S100424_RS00545	COG1737	Transcriptional regulator
S100424_RS00555	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
S100424_RS00555	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
S100424_RS00555	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
S100424_RS00560	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
S100424_RS00570	COG1028	Short-chain dehydrogenase reductase Sdr
S100424_RS00575	COG4876	unkown
S100424_RS00590	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
S100424_RS00600	COG1737	Transcriptional regulator
S100424_RS00605	COG1285	pathogenesis
S100424_RS00610	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S100424_RS00615	COG3715	PTS system
S100424_RS00620	COG3716	PTS system mannose fructose sorbose family IID component
S100424_RS00655	COG0028	Belongs to the TPP enzyme family
S100424_RS00715	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
S100424_RS00720	COG0531	amino acid
S100424_RS00725	COG2957	Belongs to the agmatine deiminase family
S100424_RS00740	COG0656	L-ascorbic acid biosynthetic process
S100424_RS00760	COG3715	PTS system
S100424_RS00765	COG3716	PTS system mannose fructose sorbose family IID component
S100424_RS00770	COG2222	sugar isomerase
S100424_RS00785	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
S100424_RS00790	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
S100424_RS00795	COG0813	purine-nucleoside phosphorylase activity
S100424_RS00800	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
S100424_RS00810	COG2390	Transcriptional regulator
S100424_RS00815	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
S100424_RS00830	COG3940	Belongs to the glycosyl hydrolase 43 family
S100424_RS00845	COG1442	glycosyl transferase family 8
S100424_RS00860	COG1929	Belongs to the glycerate kinase type-1 family
S100424_RS00865	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
S100424_RS00870	COG0697	spore germination
S100424_RS00875	COG0438	transferase activity, transferring glycosyl groups
S100424_RS00880	COG0438	transferase activity, transferring glycosyl groups
S100424_RS00885	COG0778	Nitroreductase
S100424_RS00895	COG1733	regulation of RNA biosynthetic process
S100424_RS00900	COG0604	alcohol dehydrogenase
S100424_RS00905	COG0351	phosphomethylpyrimidine kinase
S100424_RS00920	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S100424_RS00950	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
S100424_RS00955	COG2814	Major facilitator Superfamily
S100424_RS00985	COG0402	S-adenosylhomocysteine deaminase activity
S100424_RS00990	COG1174	glycine betaine transport
S100424_RS01010	COG3973	AAA domain
S100424_RS01045	COG1801	Protein of unknown function DUF72
S100424_RS01050	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
S100424_RS01050	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
S100424_RS01055	COG0084	hydrolase, TatD family'
S100424_RS01065	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
S100424_RS01070	COG4466	Protein conserved in bacteria
S100424_RS01075	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
S100424_RS01085	COG0589	response to stress
S100424_RS01095	COG0477	Major facilitator Superfamily
S100424_RS01105	COG3842	ATPase activity
S100424_RS01110	COG4120	Belongs to the binding-protein-dependent transport system permease family
S100424_RS01120	COG2188	Transcriptional regulator
S100424_RS01125	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S100424_RS01130	COG1447	Phosphotransferase system cellobiose-specific component IIA
S100424_RS01135	COG2723	6-phospho-beta-galactosidase activity
S100424_RS01145	COG0446	pyridine nucleotide-disulphide oxidoreductase
S100424_RS01165	COG1288	antiporter activity
S100424_RS01170	COG1573	uracil-dna glycosylase
S100424_RS01175	COG0803	Belongs to the bacterial solute-binding protein 9 family
S100424_RS01180	COG1121	(ABC) transporter
S100424_RS01185	COG1108	ABC-type Mn2 Zn2 transport systems permease components
S100424_RS01190	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
S100424_RS01195	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
S100424_RS01205	COG0577	efflux transmembrane transporter activity
S100424_RS01275	COG4869	propanediol catabolic process
S100424_RS01285	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
S100424_RS01300	COG1012	belongs to the aldehyde dehydrogenase family
S100424_RS01310	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
S100424_RS01320	COG1902	pentaerythritol trinitrate reductase activity
S100424_RS01325	COG2365	Tyrosine phosphatase family
S100424_RS01330	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
S100424_RS01355	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
S100424_RS01360	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
S100424_RS01380	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
S100424_RS01385	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
S100424_RS01395	COG3590	peptidase
S100424_RS01400	COG2502	aspartate--ammonia ligase
S100424_RS01405	COG2252	PERMEase
S100424_RS01410	COG0328	RNA-DNA hybrid ribonuclease activity
S100424_RS01415	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
S100424_RS01430	COG1215	transferase activity, transferring glycosyl groups
S100424_RS01460	COG2855	membrane
S100424_RS01475	COG0561	phosphatase activity
S100424_RS01480	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
S100424_RS01485	COG0540	Belongs to the ATCase OTCase family
S100424_RS01490	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
S100424_RS01495	COG0505	Belongs to the CarA family
S100424_RS01500	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
S100424_RS01505	COG0167	dihydroorotate dehydrogenase activity
S100424_RS01510	COG1053	succinate dehydrogenase
S100424_RS01520	COG2814	Major facilitator Superfamily
S100424_RS01525	COG0346	lactoylglutathione lyase activity
S100424_RS01540	COG0363	glucosamine-6-phosphate deaminase activity
S100424_RS01545	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
S100424_RS01550	COG0280	phosphate acetyltransferase
S100424_RS01555	COG0735	belongs to the Fur family
S100424_RS01560	COG2814	Major facilitator Superfamily
S100424_RS01565	COG1295	ribonuclease BN
S100424_RS01575	COG2365	Tyrosine phosphatase family
S100424_RS01580	COG2365	Tyrosine phosphatase family
S100424_RS01585	COG1780	Probably involved in ribonucleotide reductase function
S100424_RS01590	COG0561	phosphatase activity
S100424_RS01595	COG1131	(ABC) transporter
S100424_RS01600	COG3559	Exporter of polyketide antibiotics
S100424_RS01605	COG1253	flavin adenine dinucleotide binding
S100424_RS01610	COG4989	oxidoreductase activity
S100424_RS01625	COG1737	Transcriptional regulator
S100424_RS01630	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S100424_RS01630	COG1263	PTS System
S100424_RS01635	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
S100424_RS01640	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
S100424_RS01645	COG2188	Transcriptional regulator
S100424_RS01650	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
S100424_RS01655	COG1051	belongs to the nudix hydrolase family
S100424_RS01660	COG0564	pseudouridine synthase activity
S100424_RS01670	COG1940	carbohydrate kinase activity
S100424_RS01675	COG1811	Na channel or pump
S100424_RS01685	COG2084	Dehydrogenase
S100424_RS01695	COG1376	ErfK ybiS ycfS ynhG family protein
S100424_RS01705	COG0586	Pfam SNARE associated Golgi protein
S100424_RS01725	COG0025	NhaP-type Na H and K H
S100424_RS01735	COG0492	ferredoxin-NADP+ reductase activity
S100424_RS01740	COG1368	sulfuric ester hydrolase activity
S100424_RS01765	COG0861	Integral membrane protein TerC family
S100424_RS01770	COG3118	belongs to the thioredoxin family
S100424_RS01795	COG0488	(ABC) transporter
S100424_RS01805	COG0656	L-ascorbic acid biosynthetic process
S100424_RS01810	COG2267	carboxylic ester hydrolase activity
S100424_RS01820	COG2936	dipeptidyl-peptidase activity
S100424_RS01825	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
S100424_RS01830	COG2252	PERMEase
S100424_RS01835	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
S100424_RS01840	COG0531	amino acid
S100424_RS01855	COG0194	GDP metabolic process
S100424_RS01860	COG0735	belongs to the Fur family
S100424_RS01880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S100424_RS01885	COG0765	amino acid transport
S100424_RS01890	COG0765	amino acid transport
S100424_RS01895	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
S100424_RS01900	COG0406	alpha-ribazole phosphatase activity
S100424_RS01905	COG0531	amino acid
S100424_RS01910	COG0588	phosphoglycerate mutase activity
S100424_RS01915	COG3973	AAA domain
S100424_RS01920	COG0028	Belongs to the TPP enzyme family
S100424_RS01925	COG3527	Alpha-acetolactate decarboxylase
S100424_RS01930	COG1072	(Pantothenic acid kinase))
S100424_RS01940	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
S100424_RS01945	COG2217	Heavy metal translocating P-type atpase
S100424_RS01960	COG0518	GMP synthase (glutamine-hydrolyzing) activity
S100424_RS01960	COG0519	Catalyzes the synthesis of GMP from XMP
S100424_RS01970	COG0477	Major facilitator Superfamily
S100424_RS01975	COG0308	aminopeptidase N
S100424_RS01985	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
S100424_RS01990	COG1518	maintenance of DNA repeat elements
S100424_RS02010	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
S100424_RS02015	COG0459	protein refolding
S100424_RS02020	COG0531	amino acid
S100424_RS02025	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
S100424_RS02030	COG1739	Uncharacterized protein family UPF0029
S100424_RS02035	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
S100424_RS02050	COG0653	protein targeting
S100424_RS02055	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
S100424_RS02060	COG0745	RESPONSE REGULATOR receiver
S100424_RS02065	COG5002	protein histidine kinase activity
S100424_RS02075	COG0573	inorganic phosphate transmembrane transporter activity
S100424_RS02080	COG0581	inorganic phosphate transmembrane transporter activity
S100424_RS02090	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
S100424_RS02095	COG0704	Plays a role in the regulation of phosphate uptake
S100424_RS02110	COG1950	PFAM Membrane protein of
S100424_RS02115	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
S100424_RS02120	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
S100424_RS02125	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
S100424_RS02135	COG0492	ferredoxin-NADP+ reductase activity
S100424_RS02140	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
S100424_RS02150	COG0556	nucleotide-excision repair
S100424_RS02155	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
S100424_RS02160	COG1660	Displays ATPase and GTPase activities
S100424_RS02165	COG0391	Required for morphogenesis under gluconeogenic growth conditions
S100424_RS02170	COG1481	regulation of sporulation
S100424_RS02175	COG1388	LysM domain
S100424_RS02175	COG1705	Flagellar rod assembly protein muramidase FlgJ
S100424_RS02185	COG0740	serine-type endopeptidase activity
S100424_RS02195	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
S100424_RS02200	COG2390	Transcriptional regulator
S100424_RS02210	COG0126	phosphoglycerate kinase activity
S100424_RS02215	COG0149	triose-phosphate isomerase activity
S100424_RS02220	COG0148	phosphopyruvate hydratase activity
S100424_RS02225	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
S100424_RS02230	COG0557	exoribonuclease II activity
S100424_RS02235	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
S100424_RS02250	COG0561	phosphatase activity
S100424_RS02255	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
S100424_RS02260	COG0802	atpase or kinase
S100424_RS02265	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S100424_RS02280	COG0812	UDP-N-acetylmuramate dehydrogenase activity
S100424_RS02285	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
S100424_RS02295	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
S100424_RS02300	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
S100424_RS02320	COG1011	Hydrolase
S100424_RS02325	COG3479	Phenolic acid decarboxylase
S100424_RS02330	COG1695	Transcriptional regulator
S100424_RS02335	COG1028	Short-chain dehydrogenase reductase Sdr
S100424_RS02350	COG4690	dipeptidase activity
S100424_RS02365	COG1122	ATPase activity
S100424_RS02380	COG1328	CTP reductase activity
S100424_RS02390	COG0396	ATPase activity
S100424_RS02395	COG0719	Fe-S assembly protein
S100424_RS02400	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
S100424_RS02405	COG0822	iron-sulfur transferase activity
S100424_RS02410	COG0719	Fe-S assembly protein
S100424_RS02415	COG2095	MarC family integral membrane protein
S100424_RS02435	COG1694	Mazg nucleotide pyrophosphohydrolase
S100424_RS02440	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
S100424_RS02450	COG1063	alcohol dehydrogenase
S100424_RS02455	COG0367	asparagine synthase
S100424_RS02480	COG1442	glycosyl transferase family 8
S100424_RS02575	COG3475	LICD family
S100424_RS02585	COG3397	chitin binding
S100424_RS02595	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
S100424_RS02600	COG0351	phosphomethylpyrimidine kinase
S100424_RS02605	COG0352	thiamine-phosphate diphosphorylase activity
S100424_RS02615	COG0514	ATP-dependent DNA helicase (RecQ)
S100424_RS02620	COG5549	protein import
S100424_RS02620	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
S100424_RS02635	COG0489	protein tyrosine kinase activity
S100424_RS02640	COG4464	protein tyrosine phosphatase activity
S100424_RS02645	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
S100424_RS02655	COG0438	transferase activity, transferring glycosyl groups
S100424_RS02675	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
S100424_RS02685	COG1088	dTDP-glucose 4,6-dehydratase activity
S100424_RS02695	COG2244	polysaccharide biosynthetic process
S100424_RS02700	COG3408	Glycogen debranching enzyme
S100424_RS02700	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
S100424_RS02705	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
S100424_RS02705	COG3711	transcriptional antiterminator
S100424_RS02720	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
S100424_RS02730	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
S100424_RS02740	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
S100424_RS02750	COG0210	DNA helicase
S100424_RS02785	COG2217	Heavy metal translocating P-type atpase
S100424_RS02795	COG0531	amino acid
S100424_RS02810	COG0673	inositol 2-dehydrogenase activity
S100424_RS02815	COG0513	Belongs to the DEAD box helicase family
S100424_RS02820	COG1316	TRANSCRIPTIONal
S100424_RS02840	COG0516	GMP reductase activity
S100424_RS02845	COG0542	response to heat
S100424_RS02865	COG0596	Alpha beta hydrolase
S100424_RS02870	COG0438	transferase activity, transferring glycosyl groups
S100424_RS02875	COG0438	transferase activity, transferring glycosyl groups
S100424_RS03010	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
S100424_RS03015	COG0477	Major facilitator Superfamily
S100424_RS03020	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
S100424_RS03025	COG0671	phosphoesterase, PA-phosphatase related
S100424_RS03030	COG0495	leucyl-tRNA aminoacylation
S100424_RS03035	COG2244	polysaccharide biosynthetic process
S100424_RS03040	COG1187	pseudouridine synthase activity
S100424_RS03045	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
S100424_RS03050	COG0589	response to stress
S100424_RS03055	COG0154	amidase activity
S100424_RS03060	COG1428	Deoxynucleoside kinase
S100424_RS03095	COG0367	asparagine synthase
S100424_RS03100	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
S100424_RS03110	COG1794	racemase activity, acting on amino acids and derivatives
S100424_RS03120	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
S100424_RS03125	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
S100424_RS03140	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
S100424_RS03145	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
S100424_RS03165	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S100424_RS03170	COG1940	carbohydrate kinase activity
S100424_RS03175	COG2723	6-phospho-beta-galactosidase activity
S100424_RS03195	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
S100424_RS03195	COG3711	transcriptional antiterminator
S100424_RS03205	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
S100424_RS03205	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
S100424_RS03205	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
S100424_RS03230	COG2017	converts alpha-aldose to the beta-anomer
S100424_RS03255	COG2160	L-arabinose isomerase activity
S100424_RS03270	COG0531	amino acid
S100424_RS03275	COG1297	OPT oligopeptide transporter protein
S100424_RS03310	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S100424_RS03335	COG1070	Carbohydrate kinase
S100424_RS03340	COG2814	Major facilitator Superfamily
S100424_RS03355	COG0446	pyridine nucleotide-disulphide oxidoreductase
S100424_RS03360	COG1054	Belongs to the UPF0176 family
S100424_RS03365	COG1937	Protein conserved in bacteria
S100424_RS03390	COG1609	Transcriptional regulator
S100424_RS03395	COG2017	converts alpha-aldose to the beta-anomer
S100424_RS03400	COG2211	Major facilitator Superfamily
S100424_RS03400	COG2190	(PTS) system
S100424_RS03415	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
S100424_RS03420	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
S100424_RS03425	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
S100424_RS03435	COG0531	amino acid
S100424_RS03460	COG0667	Aldo Keto reductase
S100424_RS03465	COG0018	arginyl-trna synthetase
S100424_RS03475	COG1438	arginine binding
S100424_RS03480	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
S100424_RS03485	COG3679	Belongs to the UPF0342 family
S100424_RS03490	COG0420	3'-5' exonuclease activity
S100424_RS03495	COG4717	serine-type aminopeptidase activity
S100424_RS03505	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
S100424_RS03515	COG0537	adenosine 5'-monophosphoramidase activity
S100424_RS03520	COG1131	(ABC) transporter
S100424_RS03525	COG4473	ABC transporter
S100424_RS03530	COG0220	tRNA (guanine-N7-)-methyltransferase activity
S100424_RS03540	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
S100424_RS03545	COG1674	ftsk spoiiie
S100424_RS03550	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
S100424_RS03555	COG0670	Belongs to the BI1 family
S100424_RS03560	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
S100424_RS03560	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
S100424_RS03565	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
S100424_RS03575	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
S100424_RS03585	COG1484	DNA-dependent DNA replication
S100424_RS03590	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
S100424_RS03595	COG3275	phosphorelay sensor kinase activity
S100424_RS03600	COG3279	Response regulator of the LytR AlgR family
S100424_RS03610	COG1346	cytolysis
S100424_RS03615	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
S100424_RS03620	COG0291	Belongs to the bacterial ribosomal protein bL35 family
S100424_RS03625	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
S100424_RS03630	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
S100424_RS03635	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
S100424_RS03640	COG1534	Rna-binding protein
S100424_RS03645	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
S100424_RS03650	COG1713	HD superfamily hydrolase involved in NAD metabolism
S100424_RS03655	COG0799	negative regulation of ribosome biogenesis
S100424_RS03660	COG2226	methyltransferase
S100424_RS03665	COG1323	Belongs to the UPF0348 family
S100424_RS03670	COG1399	metal-binding, possibly nucleic acid-binding protein
S100424_RS03675	COG0333	Belongs to the bacterial ribosomal protein bL32 family
S100424_RS03680	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
S100424_RS03685	COG0745	RESPONSE REGULATOR receiver
S100424_RS03690	COG5002	protein histidine kinase activity
S100424_RS03695	COG2814	Major facilitator Superfamily
S100424_RS03700	COG3408	Glycogen debranching enzyme
S100424_RS03700	COG3119	arylsulfatase activity
S100424_RS03705	COG0706	membrane insertase activity
S100424_RS03710	COG1254	Belongs to the acylphosphatase family
S100424_RS03715	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
S100424_RS03725	COG1733	regulation of RNA biosynthetic process
S100424_RS03730	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
S100424_RS03735	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
S100424_RS03735	COG0072	phenylalanine-tRNA ligase activity
S100424_RS03740	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
S100424_RS03745	COG0572	uridine kinase
S100424_RS03750	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
S100424_RS03755	COG4485	Bacterial membrane protein, YfhO
S100424_RS03760	COG0768	penicillin binding
S100424_RS03765	COG0267	Belongs to the bacterial ribosomal protein bL33 family
S100424_RS03770	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
S100424_RS03775	COG0705	Rhomboid family
S100424_RS03785	COG1940	carbohydrate kinase activity
S100424_RS03790	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
S100424_RS03800	COG0584	glycerophosphoryl diester phosphodiesterase
S100424_RS03805	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
S100424_RS03810	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
S100424_RS03815	COG0789	Transcriptional regulator
S100424_RS03860	COG0261	This protein binds to 23S rRNA in the presence of protein L20
S100424_RS03870	COG0211	Belongs to the bacterial ribosomal protein bL27 family
S100424_RS03875	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
S100424_RS03880	COG1302	Protein conserved in bacteria
S100424_RS03885	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
S100424_RS03890	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
S100424_RS03895	COG1570	exodeoxyribonuclease VII activity
S100424_RS03900	COG1722	exodeoxyribonuclease VII activity
S100424_RS03910	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
S100424_RS03915	COG1438	arginine binding
S100424_RS03920	COG0497	DNA recombination
S100424_RS03940	COG1758	RNA polymerase activity
S100424_RS03945	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
S100424_RS03950	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
S100424_RS03955	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
S100424_RS03960	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
S100424_RS03960	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
S100424_RS03965	COG0631	protein serine/threonine phosphatase activity
S100424_RS03970	COG0515	serine threonine protein kinase
S100424_RS03970	COG2815	serine threonine protein kinase
S100424_RS03975	COG1162	GTPase activity
S100424_RS03980	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
S100424_RS03990	COG0227	Belongs to the bacterial ribosomal protein bL28 family
S100424_RS04005	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
S100424_RS04010	COG0416	fatty acid biosynthetic process
S100424_RS04015	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
S100424_RS04020	COG0571	ribonuclease III activity
S100424_RS04025	COG1196	nuclear chromosome segregation
S100424_RS04030	COG0552	protein localization to endoplasmic reticulum
S100424_RS04035	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
S100424_RS04040	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
S100424_RS04045	COG0228	four-way junction DNA binding
S100424_RS04050	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
S100424_RS04055	COG0336	Belongs to the RNA methyltransferase TrmD family
S100424_RS04060	COG4619	ABC transporter
S100424_RS04065	COG0390	transport system, permease component
S100424_RS04070	COG0335	large ribosomal subunit rRNA binding
S100424_RS04080	COG0393	Putative heavy-metal-binding
S100424_RS04090	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
S100424_RS04095	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
S100424_RS04105	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
S100424_RS04110	COG1028	Short-chain dehydrogenase reductase Sdr
S100424_RS04115	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
S100424_RS04120	COG0511	ligase activity, forming carbon-carbon bonds
S100424_RS04130	COG0439	Biotin carboxylase
S100424_RS04135	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
S100424_RS04140	COG0825	malonyl-CoA metabolic process
S100424_RS04145	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
S100424_RS04175	COG1396	sequence-specific DNA binding
S100424_RS04230	COG0629	single-stranded DNA binding
S100424_RS04260	COG5484	DNA packaging
S100424_RS04410	COG3425	synthase
S100424_RS04420	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
S100424_RS04425	COG4224	UPF0291 protein
S100424_RS04430	COG3763	UPF0154 protein
S100424_RS04435	COG0204	Acyl-transferase
S100424_RS04440	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
S100424_RS04460	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
S100424_RS04465	COG0528	UMP kinase activity
S100424_RS04470	COG0233	cytoplasmic translational termination
S100424_RS04475	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
S100424_RS04480	COG4589	Belongs to the CDS family
S100424_RS04485	COG0750	zinc metalloprotease
S100424_RS04490	COG0442	prolyl-tRNA aminoacylation
S100424_RS04495	COG2176	DNA-directed DNA polymerase activity
S100424_RS04500	COG0779	Required for maturation of 30S ribosomal subunits
S100424_RS04505	COG0195	Participates in both transcription termination and antitermination
S100424_RS04510	COG2740	Nucleic-acid-binding protein implicated in transcription termination
S100424_RS04520	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
S100424_RS04525	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
S100424_RS04535	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
S100424_RS04540	COG0196	riboflavin kinase activity
S100424_RS04545	COG1420	regulation of RNA biosynthetic process
S100424_RS04550	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
S100424_RS04555	COG0443	Heat shock 70 kDa protein
S100424_RS04560	COG0484	heat shock protein binding
S100424_RS04565	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
S100424_RS04570	COG2155	Conserved Protein
S100424_RS04580	COG1131	(ABC) transporter
S100424_RS04595	COG0583	DNA-binding transcription factor activity
S100424_RS04600	COG2223	nitrite transmembrane transporter activity
S100424_RS04605	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
S100424_RS04610	COG4708	membrane
S100424_RS04620	COG1028	Short-chain dehydrogenase reductase Sdr
S100424_RS04635	COG0531	amino acid
S100424_RS04640	COG3250	beta-galactosidase activity
S100424_RS04670	COG1942	4-Oxalocrotonate Tautomerase
S100424_RS04675	COG0561	phosphatase activity
S100424_RS04680	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
S100424_RS04680	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
S100424_RS04685	COG1304	FMN binding
S100424_RS04705	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
S100424_RS04705	COG1199	ATP-dependent helicase activity
S100424_RS04715	COG3935	DnaD domain protein
S100424_RS04720	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
S100424_RS04725	COG3331	DNA recombination
S100424_RS04730	COG4474	Belongs to the UPF0398 family
S100424_RS04735	COG3599	regulation of cell shape
S100424_RS04745	COG0116	Belongs to the methyltransferase superfamily
S100424_RS04750	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
S100424_RS04760	COG2759	Belongs to the formate--tetrahydrofolate ligase family
S100424_RS04770	COG0564	pseudouridine synthase activity
S100424_RS04775	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
S100424_RS04785	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
S100424_RS04790	COG1293	RNA-binding protein homologous to eukaryotic snRNP
S100424_RS04800	COG1307	EDD domain protein, DegV family
S100424_RS04810	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
S100424_RS04820	COG1609	Transcriptional regulator
S100424_RS04830	COG1288	antiporter activity
S100424_RS04835	COG1316	TRANSCRIPTIONal
S100424_RS04840	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
S100424_RS04845	COG2814	Major facilitator Superfamily
S100424_RS04855	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
S100424_RS04860	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
S100424_RS04860	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
S100424_RS04870	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
S100424_RS04870	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
S100424_RS04875	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
S100424_RS04880	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
S100424_RS04885	COG0285	dihydrofolate synthase activity
S100424_RS04890	COG0302	gtp cyclohydrolase
S100424_RS04895	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
S100424_RS04895	COG0302	gtp cyclohydrolase
S100424_RS04915	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
S100424_RS04920	COG1929	Belongs to the glycerate kinase type-1 family
S100424_RS04925	COG2610	gluconate transmembrane transporter activity
S100424_RS04930	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
S100424_RS04935	COG1227	inorganic diphosphatase activity
S100424_RS04940	COG0583	DNA-binding transcription factor activity
S100424_RS04945	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
S100424_RS04950	COG0187	DNA topoisomerase II activity
S100424_RS04965	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
S100424_RS04970	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
S100424_RS04975	COG4974	Belongs to the 'phage' integrase family
S100424_RS04980	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
S100424_RS04985	COG0758	DNA mediated transformation
S100424_RS04990	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
S100424_RS05005	COG0446	pyridine nucleotide-disulphide oxidoreductase
S100424_RS05010	COG0477	Major facilitator Superfamily
S100424_RS05015	COG0640	Transcriptional regulator
S100424_RS05025	COG0183	Belongs to the thiolase family
S100424_RS05060	COG1131	(ABC) transporter
S100424_RS05095	COG0151	Belongs to the GarS family
S100424_RS05100	COG0138	bifunctional purine biosynthesis protein purh
S100424_RS05105	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
S100424_RS05110	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
S100424_RS05120	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
S100424_RS05125	COG0047	phosphoribosylformylglycinamidine synthase activity
S100424_RS05130	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
S100424_RS05135	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
S100424_RS05140	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
S100424_RS05145	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
S100424_RS05165	COG1131	(ABC) transporter
S100424_RS05170	COG1395	domain, Protein
S100424_RS05195	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
S100424_RS05200	COG2022	thiamine diphosphate biosynthetic process
S100424_RS05205	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
S100424_RS05215	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
S100424_RS05235	COG3052	prosthetic group binding
S100424_RS05245	COG3493	citrate carrier protein
S100424_RS05250	COG0281	malic enzyme
S100424_RS05260	COG0105	UTP biosynthetic process
S100424_RS05315	COG2723	6-phospho-beta-galactosidase activity
S100424_RS05320	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S100424_RS05320	COG1263	PTS System
S100424_RS05320	COG2190	(PTS) system
S100424_RS05335	COG0531	amino acid
S100424_RS05345	COG1393	Belongs to the ArsC family
S100424_RS05350	COG0793	Belongs to the peptidase S41A family
S100424_RS05350	COG3409	Peptidoglycan-binding domain 1 protein
S100424_RS05355	COG4479	Belongs to the UPF0346 family
S100424_RS05365	COG2755	lipolytic protein G-D-S-L family
S100424_RS05370	COG1307	EDD domain protein, DegV family
S100424_RS05380	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
S100424_RS05385	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
S100424_RS05390	COG0488	(ABC) transporter
S100424_RS05395	COG0617	tRNA 3'-terminal CCA addition
S100424_RS05400	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
S100424_RS05415	COG0457	Tetratricopeptide repeat
S100424_RS05425	COG1160	GTP binding
S100424_RS05430	COG0539	negative regulation of cytoplasmic translation
S100424_RS05435	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
S100424_RS05445	COG0514	ATP-dependent DNA helicase (RecQ)
S100424_RS05455	COG1187	pseudouridine synthase activity
S100424_RS05460	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
S100424_RS05465	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
S100424_RS05485	COG2707	UPF0756 membrane protein
S100424_RS05495	COG0205	6-phosphofructokinase activity
S100424_RS05500	COG0587	DNA-directed DNA polymerase activity
S100424_RS05510	COG0542	response to heat
S100424_RS05515	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
S100424_RS05520	COG2384	SAM-dependent methyltransferase
S100424_RS05525	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
S100424_RS05530	COG0358	DNA primase activity
S100424_RS05535	COG0751	glycine-tRNA ligase activity
S100424_RS05540	COG0752	glycyl-tRNA synthetase alpha subunit
S100424_RS05545	COG1381	Involved in DNA repair and RecF pathway recombination
S100424_RS05550	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
S100424_RS05560	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
S100424_RS05565	COG1702	phosphate starvation-inducible protein PhoH
S100424_RS05575	COG0828	Belongs to the bacterial ribosomal protein bS21 family
S100424_RS05580	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
S100424_RS05590	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
S100424_RS05595	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
S100424_RS05610	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
S100424_RS05615	COG0124	histidyl-tRNA synthetase
S100424_RS05625	COG0546	phosphoglycolate phosphatase activity
S100424_RS05630	COG1490	D-aminoacyl-tRNA deacylase activity
S100424_RS05635	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
S100424_RS05645	COG1385	rRNA (uridine-N3-)-methyltransferase activity
S100424_RS05650	COG2264	protein methyltransferase activity
S100424_RS05675	COG0436	Aminotransferase
S100424_RS05680	COG1088	dTDP-glucose 4,6-dehydratase activity
S100424_RS05690	COG2153	protein acetylation
S100424_RS05695	COG1132	(ABC) transporter
S100424_RS05705	COG0778	Nitroreductase
S100424_RS05730	COG1304	FMN binding
S100424_RS05810	COG0629	single-stranded DNA binding
S100424_RS06065	COG0305	Participates in initiation and elongation during chromosome replication
S100424_RS06110	COG1396	sequence-specific DNA binding
S100424_RS06160	COG2261	transglycosylase associated protein
S100424_RS06175	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
S100424_RS06200	COG1131	(ABC) transporter
S100424_RS06220	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
S100424_RS06225	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
S100424_RS06225	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
S100424_RS06230	COG0300	oxidoreductase activity
S100424_RS06235	COG1234	tRNA 3'-trailer cleavage
S100424_RS06245	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
S100424_RS06250	COG0322	excinuclease ABC activity
S100424_RS06255	COG1126	abc transporter atp-binding protein
S100424_RS06260	COG0765	amino acid transport
S100424_RS06270	COG0218	Necessary for normal cell division and for the maintenance of normal septation
S100424_RS06275	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
S100424_RS06280	COG0544	peptidyl-prolyl cis-trans isomerase activity
S100424_RS06285	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
S100424_RS06300	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
S100424_RS06305	COG0268	Binds directly to 16S ribosomal RNA
S100424_RS06320	COG2131	deaminase
S100424_RS06325	COG1596	polysaccharide export
S100424_RS06325	COG1555	photosystem II stabilization
S100424_RS06330	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
S100424_RS06335	COG0742	ribosomal rna small subunit methyltransferase
S100424_RS06340	COG4471	UPF0298 protein
S100424_RS06345	COG0772	Belongs to the SEDS family
S100424_RS06350	COG1217	gtp-binding protein TYPA
S100424_RS06355	COG0483	inositol monophosphate 1-phosphatase activity
S100424_RS06360	COG4476	Belongs to the UPF0223 family
S100424_RS06365	COG0242	peptide deformylase activity
S100424_RS06375	COG5503	Protein of unknown function (DUF1447)
S100424_RS06390	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
S100424_RS06390	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
S100424_RS06390	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
S100424_RS06395	COG1105	Belongs to the carbohydrate kinase PfkB family
S100424_RS06400	COG1349	DNA-binding transcription factor activity
S100424_RS06405	COG0628	permease
S100424_RS06410	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
S100424_RS06415	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
S100424_RS06430	COG0482	sulfurtransferase activity
S100424_RS06440	COG1104	cysteine desulfurase activity
S100424_RS06445	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
S100424_RS06455	COG0494	nUDIX hydrolase
S100424_RS06460	COG1278	Cold shock
S100424_RS06465	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
S100424_RS06470	COG3599	regulation of cell shape
S100424_RS06475	COG2302	S4 RNA-binding domain
S100424_RS06490	COG0849	cell division
S100424_RS06495	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
S100424_RS06500	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
S100424_RS06505	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
S100424_RS06510	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
S100424_RS06515	COG0768	penicillin binding
S100424_RS06525	COG0275	rRNA processing
S100424_RS06530	COG2001	Belongs to the MraZ family
S100424_RS06540	COG1674	ftsk spoiiie
S100424_RS06550	COG0628	permease
S100424_RS06560	COG2706	6-phosphogluconolactonase activity
S100424_RS06565	COG3142	Participates in the control of copper homeostasis
S100424_RS06570	COG2239	Acts as a magnesium transporter
S100424_RS06575	COG0564	pseudouridine synthase activity
S100424_RS06580	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
S100424_RS06585	COG2357	RelA SpoT domain protein
S100424_RS06600	COG4862	establishment of competence for transformation
S100424_RS06605	COG1393	Belongs to the ArsC family
S100424_RS06610	COG1234	tRNA 3'-trailer cleavage
S100424_RS06690	COG1185	polyribonucleotide nucleotidyltransferase activity
S100424_RS06695	COG0586	Pfam SNARE associated Golgi protein
S100424_RS06705	COG0647	UMP catabolic process
S100424_RS06710	COG4470	Protein conserved in bacteria
S100424_RS06720	COG0827	DNA restriction-modification system
S100424_RS06745	COG4537	Required for transformation and DNA binding
S100424_RS06750	COG1459	type II secretion system
S100424_RS06755	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
S100424_RS06765	COG0217	transcriptional regulatory protein
S100424_RS06770	COG2132	Multicopper oxidase
S100424_RS06775	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
S100424_RS06780	COG1335	isochorismatase
S100424_RS06785	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
S100424_RS06790	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
S100424_RS06800	COG1733	regulation of RNA biosynthetic process
S100424_RS06810	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
S100424_RS06815	COG1609	Transcriptional regulator
S100424_RS06820	COG0006	proline dipeptidase activity
S100424_RS06835	COG0668	transmembrane transport
S100424_RS06840	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
S100424_RS06845	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
S100424_RS06850	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
S100424_RS06850	COG0574	Belongs to the PEP-utilizing enzyme family
S100424_RS06855	COG3118	belongs to the thioredoxin family
S100424_RS06860	COG1193	negative regulation of DNA recombination
S100424_RS06865	COG3906	Belongs to the UPF0473 family
S100424_RS06870	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
S100424_RS06875	COG4472	Bacterial protein of unknown function (DUF965)
S100424_RS06880	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
S100424_RS06885	COG0513	Belongs to the DEAD box helicase family
S100424_RS06890	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
S100424_RS06895	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
S100424_RS06900	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
S100424_RS06905	COG1862	Preprotein translocase
S100424_RS06910	COG0343	queuine tRNA-ribosyltransferase activity
S100424_RS06915	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
S100424_RS06920	COG2255	four-way junction helicase activity
S100424_RS06925	COG0632	four-way junction helicase activity
S100424_RS06930	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
S100424_RS06935	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
S100424_RS06940	COG1418	mRNA catabolic process
S100424_RS06950	COG1058	Belongs to the CinA family
S100424_RS06950	COG1546	Belongs to the CinA family
S100424_RS06955	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
S100424_RS06965	COG0300	oxidoreductase activity
S100424_RS06970	COG0612	Peptidase, M16
S100424_RS06975	COG0612	Peptidase, M16
S100424_RS06980	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
S100424_RS06985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S100424_RS06990	COG1126	abc transporter atp-binding protein
S100424_RS06995	COG0765	amino acid transport
S100424_RS07010	COG2003	Belongs to the UPF0758 family
S100424_RS07015	COG0285	dihydrofolate synthase activity
S100424_RS07020	COG0525	valine-tRNA ligase activity
S100424_RS07030	COG0301	tRNA thio-modification
S100424_RS07035	COG1104	cysteine desulfurase activity
S100424_RS07040	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
S100424_RS07045	COG1956	GAF domain-containing protein
S100424_RS07050	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
S100424_RS07055	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
S100424_RS07070	COG0589	response to stress
S100424_RS07085	COG1181	Belongs to the D-alanine--D-alanine ligase family
S100424_RS07095	COG0531	amino acid
S100424_RS07110	COG1131	(ABC) transporter
S100424_RS07115	COG1725	Transcriptional regulator
S100424_RS07125	COG1464	Belongs to the NlpA lipoprotein family
S100424_RS07130	COG2011	ABC-type metal ion transport system permease component
S100424_RS07135	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
S100424_RS07140	COG0772	Belongs to the SEDS family
S100424_RS07150	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
S100424_RS07155	COG4836	Membrane
S100424_RS07160	COG0355	proton-transporting ATP synthase activity, rotational mechanism
S100424_RS07165	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
S100424_RS07170	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
S100424_RS07175	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
S100424_RS07180	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
S100424_RS07185	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
S100424_RS07190	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
S100424_RS07195	COG0356	it plays a direct role in the translocation of protons across the membrane
S100424_RS07215	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
S100424_RS07220	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
S100424_RS07225	COG0009	L-threonylcarbamoyladenylate synthase
S100424_RS07230	COG2890	protein-(glutamine-N5) methyltransferase activity
S100424_RS07240	COG1435	thymidine kinase activity
S100424_RS07245	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
S100424_RS07250	COG3442	glutamine amidotransferase
S100424_RS07255	COG1482	cell wall glycoprotein biosynthetic process
S100424_RS07265	COG1132	(ABC) transporter
S100424_RS07285	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
S100424_RS07310	COG0431	NADPH-dependent FMN reductase
S100424_RS07310	COG1053	succinate dehydrogenase
S100424_RS07310	COG3976	FMN-binding domain protein
S100424_RS07320	COG0166	Belongs to the GPI family
S100424_RS07325	COG4975	Glucose uptake
S100424_RS07335	COG3850	Histidine kinase
S100424_RS07335	COG5002	protein histidine kinase activity
S100424_RS07340	COG0745	RESPONSE REGULATOR receiver
S100424_RS07355	COG0741	lytic transglycosylase activity
S100424_RS07365	COG2610	gluconate transmembrane transporter activity
S100424_RS07370	COG1070	Carbohydrate kinase
S100424_RS07375	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
S100424_RS07380	COG1737	Transcriptional regulator
S100424_RS07405	COG1073	alpha beta
S100424_RS07440	COG0730	response to heat
S100424_RS07445	COG1368	sulfuric ester hydrolase activity
S100424_RS07450	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
S100424_RS07455	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
S100424_RS07460	COG0628	permease
S100424_RS07465	COG3557	Belongs to the UPF0374 family
S100424_RS07470	COG2137	regulation of response to DNA damage stimulus
S100424_RS07475	COG0716	FMN binding
S100424_RS07485	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
S100424_RS07490	COG1597	lipid kinase activity
S100424_RS07495	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
S100424_RS07500	COG0154	amidase activity
S100424_RS07510	COG4851	CamS sex pheromone cAM373 precursor
S100424_RS07520	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
S100424_RS07525	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
S100424_RS07530	COG1705	Flagellar rod assembly protein muramidase FlgJ
S100424_RS07565	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
S100424_RS07580	COG0531	amino acid
S100424_RS07595	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
S100424_RS07600	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
S100424_RS07615	COG1122	ATPase activity
S100424_RS07620	COG1122	ATPase activity
S100424_RS07625	COG0203	ribosomal protein L17
S100424_RS07630	COG0202	RNA polymerase activity
S100424_RS07635	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
S100424_RS07640	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
S100424_RS07645	COG0257	Belongs to the bacterial ribosomal protein bL36 family
S100424_RS07650	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
S100424_RS07665	COG0200	Binds to the 23S rRNA
S100424_RS07670	COG1841	ribosomal large subunit assembly
S100424_RS07675	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
S100424_RS07680	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
S100424_RS07685	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
S100424_RS07690	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
S100424_RS07695	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
S100424_RS07700	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
S100424_RS07705	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
S100424_RS07710	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
S100424_RS07720	COG0255	Belongs to the universal ribosomal protein uL29 family
S100424_RS07725	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
S100424_RS07730	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
S100424_RS07735	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
S100424_RS07740	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
S100424_RS07745	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
S100424_RS07750	COG0089	rRNA binding
S100424_RS07755	COG0088	Forms part of the polypeptide exit tunnel
S100424_RS07760	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
S100424_RS07765	COG0051	transcription antitermination factor activity, RNA binding
S100424_RS07770	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
S100424_RS07775	COG0049	tRNA binding
S100424_RS07780	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
S100424_RS07790	COG1957	nucleoside hydrolase
S100424_RS07795	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
S100424_RS07800	COG0085	RNA polymerase activity
S100424_RS07805	COG0542	response to heat
S100424_RS07810	COG4463	regulation of RNA biosynthetic process
S100424_RS07815	COG0028	Belongs to the TPP enzyme family
S100424_RS07860	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
S100424_RS07865	COG1428	Deoxynucleoside kinase
S100424_RS07870	COG0833	amino acid
S100424_RS07885	COG1316	TRANSCRIPTIONal
S100424_RS07895	COG2966	Psort location CytoplasmicMembrane, score
S100424_RS07900	COG1278	Cold shock
S100424_RS07905	COG1230	cation diffusion facilitator family transporter
S100424_RS07915	COG1418	mRNA catabolic process
S100424_RS07920	COG1418	mRNA catabolic process
S100424_RS07930	COG0564	pseudouridine synthase activity
S100424_RS07950	COG4690	dipeptidase activity
S100424_RS07965	COG1476	TRANSCRIPTIONal
S100424_RS07990	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
S100424_RS08000	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
S100424_RS08010	COG1214	PFAM Peptidase M22, glycoprotease
S100424_RS08015	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
S100424_RS08030	COG4467	Involved in initiation control of chromosome replication
S100424_RS08035	COG0470	DNA polymerase III
S100424_RS08040	COG3870	Protein conserved in bacteria
S100424_RS08045	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
S100424_RS08050	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
S100424_RS08055	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
S100424_RS08060	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
S100424_RS08075	COG2813	Specifically methylates the guanine in position
S100424_RS08080	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
S100424_RS08085	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
S100424_RS08090	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
S100424_RS08095	COG0222	ribosome binding
S100424_RS08100	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
S100424_RS08105	COG0081	regulation of translation
S100424_RS08115	COG0250	Participates in transcription elongation, termination and antitermination
S100424_RS08125	COG0267	Belongs to the bacterial ribosomal protein bL33 family
S100424_RS08135	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
S100424_RS08140	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
S100424_RS08145	COG0215	cysteine-tRNA ligase activity
S100424_RS08150	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
S100424_RS08155	COG4956	integral membrane protein (PIN domain superfamily)
S100424_RS08160	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
S100424_RS08175	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
S100424_RS08185	COG0588	phosphoglycerate mutase activity
S100424_RS08190	COG0825	malonyl-CoA metabolic process
S100424_RS08200	COG0439	Biotin carboxylase
S100424_RS08210	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
S100424_RS08225	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
S100424_RS08225	COG3933	PFAM sigma-54 factor interaction domain-containing protein
S100424_RS08235	COG3716	PTS system mannose fructose sorbose family IID component
S100424_RS08240	COG3715	PTS system
S100424_RS08255	COG3091	SprT-like family
S100424_RS08260	COG2183	response to ionizing radiation
S100424_RS08280	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
S100424_RS08285	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
S100424_RS08290	COG2188	Transcriptional regulator
S100424_RS08300	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
S100424_RS08305	COG1064	alcohol dehydrogenase
S100424_RS08325	COG3104	oligopeptide transport
S100424_RS08365	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
S100424_RS08370	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
S100424_RS08375	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
S100424_RS08390	COG0037	tRNA processing
S100424_RS08395	COG1098	S1 RNA binding domain
S100424_RS08405	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
S100424_RS08410	COG2244	polysaccharide biosynthetic process
S100424_RS08415	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
S100424_RS08420	COG0193	aminoacyl-tRNA hydrolase activity
S100424_RS08440	COG2337	Toxic component of a toxin-antitoxin (TA) module
S100424_RS08465	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
S100424_RS08475	COG0501	Belongs to the peptidase M48B family
S100424_RS08480	COG1704	LemA family
S100424_RS08485	COG3764	Sortase (surface protein transpeptidase)
S100424_RS08495	COG0254	rRNA binding
S100424_RS08500	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
S100424_RS08505	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
S100424_RS08510	COG0504	CTP synthase activity
S100424_RS08515	COG3343	RNA polymerase activity
S100424_RS08525	COG1078	dGTPase activity
S100424_RS08540	COG1940	carbohydrate kinase activity
S100424_RS08570	COG0546	phosphoglycolate phosphatase activity
S100424_RS08580	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
S100424_RS08585	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
S100424_RS08590	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
S100424_RS08595	COG1696	Membrane protein involved in D-alanine export
S100424_RS08600	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S100424_RS08610	COG1268	BioY protein
S100424_RS08615	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
S100424_RS08625	COG2814	Major facilitator Superfamily
S100424_RS08635	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
S100424_RS08640	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
S100424_RS08650	COG0463	Glycosyl transferase, family 2
S100424_RS08655	COG0463	Glycosyl transferase, family 2
S100424_RS08655	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
S100424_RS08660	COG1134	teichoic acid transport
S100424_RS08665	COG1682	transport, permease protein
S100424_RS08675	COG0463	Glycosyl transferase, family 2
S100424_RS08680	COG2246	polysaccharide biosynthetic process
S100424_RS08685	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
S100424_RS08690	COG0708	Exodeoxyribonuclease III
S100424_RS08700	COG1193	negative regulation of DNA recombination
S100424_RS08725	COG0583	DNA-binding transcription factor activity
S100424_RS08730	COG0667	Aldo Keto reductase
S100424_RS08745	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
S100424_RS08750	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
S100424_RS08755	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
S100424_RS08835	COG1164	Oligoendopeptidase f
S100424_RS08850	COG2211	Major facilitator Superfamily
S100424_RS08860	COG2814	Major facilitator Superfamily
S100424_RS08865	COG1854	S-ribosylhomocysteine lyase activity
S100424_RS08875	COG0110	maltose O-acetyltransferase activity
S100424_RS08880	COG0446	pyridine nucleotide-disulphide oxidoreductase
S100424_RS08895	COG0105	UTP biosynthetic process
S100424_RS08900	COG0697	spore germination
S100424_RS08910	COG0488	(ABC) transporter
S100424_RS08920	COG0402	S-adenosylhomocysteine deaminase activity
S100424_RS08925	COG1136	(ABC) transporter
S100424_RS08925	COG0577	efflux transmembrane transporter activity
S100424_RS08930	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
S100424_RS08935	COG1174	glycine betaine transport
S100424_RS08940	COG1732	Glycine betaine
S100424_RS08960	COG0673	inositol 2-dehydrogenase activity
S100424_RS08965	COG1132	(ABC) transporter
S100424_RS08975	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
S100424_RS08980	COG1461	Dihydroxyacetone kinase
S100424_RS08985	COG2376	Dihydroxyacetone kinase
S100424_RS08990	COG2357	RelA SpoT domain protein
S100424_RS09000	COG2249	NAD(P)H dehydrogenase (quinone) activity
S100424_RS09025	COG2261	transglycosylase associated protein
S100424_RS09030	COG0667	Aldo Keto reductase
S100424_RS09040	COG0561	phosphatase activity
S100424_RS09045	COG0284	orotidine-5'-phosphate decarboxylase activity
S100424_RS09050	COG0242	peptide deformylase activity
S100424_RS09060	COG1846	Transcriptional regulator
S100424_RS09075	COG1131	(ABC) transporter
S100424_RS09080	COG0789	Transcriptional regulator
S100424_RS09085	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
S100424_RS09095	COG0583	DNA-binding transcription factor activity
S100424_RS09100	COG1902	pentaerythritol trinitrate reductase activity
S100424_RS09105	COG4975	Glucose uptake
S100424_RS09110	COG1869	D-ribose catabolic process
S100424_RS09120	COG1609	Transcriptional regulator
S100424_RS09125	COG1914	H( )-stimulated, divalent metal cation uptake system
S100424_RS09155	COG0702	epimerase
S100424_RS09165	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
S100424_RS09185	COG0697	spore germination
S100424_RS09190	COG0588	phosphoglycerate mutase activity
S100424_RS09195	COG0148	phosphopyruvate hydratase activity
S100424_RS09205	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
S100424_RS09225	COG1686	Belongs to the peptidase S11 family
S100424_RS09230	COG5002	protein histidine kinase activity
S100424_RS09235	COG0745	RESPONSE REGULATOR receiver
S100424_RS09240	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
S100424_RS09255	COG0012	GTP binding
S100424_RS09260	COG4481	Protein conserved in bacteria
S100424_RS09265	COG1475	DNA binding
S100424_RS09270	COG0357	Ribosomal RNA small subunit methyltransferase G
S100424_RS09285	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
S100424_RS09295	COG0791	NLP P60 protein
S100424_RS09305	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
S100424_RS09310	COG2197	response regulator
S100424_RS09315	COG4585	Histidine kinase
S100424_RS09320	COG0842	Transport permease protein
S100424_RS09330	COG0586	Pfam SNARE associated Golgi protein
S100424_RS09350	COG2755	lipolytic protein G-D-S-L family
S100424_RS09350	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
S100424_RS09365	COG1136	(ABC) transporter
S100424_RS09385	COG2200	EAL domain
S100424_RS09400	COG3507	Belongs to the glycosyl hydrolase 43 family
S100424_RS09405	COG2211	Major facilitator Superfamily
S100424_RS09420	COG2115	Belongs to the xylose isomerase family
S100424_RS09435	COG2017	converts alpha-aldose to the beta-anomer
S100424_RS09455	COG2222	sugar isomerase
S100424_RS09465	COG3716	PTS system mannose fructose sorbose family IID component
S100424_RS09470	COG3715	PTS system
S100424_RS09475	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S100424_RS09505	COG4708	membrane
S100424_RS09515	COG0604	alcohol dehydrogenase
S100424_RS09540	COG0095	Lipoate-protein ligase
S100424_RS09545	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S100424_RS09550	COG2723	6-phospho-beta-galactosidase activity
S100424_RS09555	COG2188	Transcriptional regulator
S100424_RS09565	COG1511	domain protein
S100424_RS09565	COG1511	domain protein
S100424_RS09570	COG0640	Transcriptional regulator
S100424_RS09585	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
S100424_RS09590	COG1609	Transcriptional regulator
S100424_RS09605	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
S100424_RS09610	COG0246	Mannitol dehydrogenase
S100424_RS09615	COG1904	glucuronate isomerase
S100424_RS09625	COG2211	Major facilitator Superfamily
S100424_RS09650	COG0438	transferase activity, transferring glycosyl groups
S100424_RS09685	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
S100424_RS09700	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
S100424_RS09705	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
S100424_RS09710	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
S100424_RS09730	COG0745	RESPONSE REGULATOR receiver
S100424_RS09745	COG0667	Aldo Keto reductase
S100424_RS09780	COG3321	synthase
S100424_RS09780	COG0604	alcohol dehydrogenase
S100424_RS09785	COG0640	Transcriptional regulator
S100424_RS09835	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S100424_RS09840	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S100424_RS09840	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S100424_RS09845	COG1609	Transcriptional regulator
S100424_RS09860	COG1970	mechanosensitive ion channel activity
S100424_RS09870	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
S100424_RS09890	COG0577	efflux transmembrane transporter activity
S100424_RS09890	COG1136	(ABC) transporter
S100424_RS09910	COG2832	Protein of unknown function (DUF454)
S100424_RS09920	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
S100424_RS09925	COG1074	ATP-dependent DNA helicase activity
S100424_RS09930	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
S100424_RS09945	COG0519	Catalyzes the synthesis of GMP from XMP
S100424_RS09955	COG1757	Na H antiporter
S100424_RS09960	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
S100424_RS09965	COG0537	adenosine 5'-monophosphoramidase activity
S100424_RS09975	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S100424_RS09985	COG1446	asparaginase
S100424_RS09995	COG2188	Transcriptional regulator
S100424_RS10000	COG3022	response to hydroperoxide
S100424_RS10005	COG0445	tRNA wobble uridine modification
S100424_RS10010	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
S100424_RS10015	COG0706	membrane insertase activity
S100424_RS10020	COG0594	ribonuclease P activity
S100424_RS10025	COG0230	Belongs to the bacterial ribosomal protein bL34 family
S100424_RS10030	COG1192	Involved in chromosome partitioning
S100424_RS10080	COG4166	transmembrane transport
S100424_RS10085	COG0601	transmembrane transport
S100424_RS10090	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
S100424_RS10095	COG0444	Belongs to the ABC transporter superfamily
S100424_RS10100	COG4608	Belongs to the ABC transporter superfamily
S100424_RS10125	COG0693	protein deglycase activity
S100424_RS10145	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
S100424_RS10160	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
S100424_RS10210	COG1940	carbohydrate kinase activity
S100424_RS10220	COG1301	dicarboxylic acid transport
S100424_RS10245	COG1609	Transcriptional regulator
S100424_RS10290	COG1181	Belongs to the D-alanine--D-alanine ligase family
S100424_RS10290	COG2918	glutathione biosynthetic process
S100424_RS10300	COG1113	amino acid transport
S100424_RS10310	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
S100424_RS10335	COG3189	MarR family transcriptional regulator