locus-tag	class	description
I6H68_RS00005	COG0577	efflux transmembrane transporter activity
I6H68_RS00005	COG1136	(ABC) transporter
I6H68_RS00010	COG1970	mechanosensitive ion channel activity
I6H68_RS00020	COG0025	NhaP-type Na H and K H
I6H68_RS00035	COG0366	Alpha amylase catalytic
I6H68_RS00040	COG2188	Transcriptional regulator
I6H68_RS00045	COG1263	PTS System
I6H68_RS00045	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6H68_RS00045	COG2190	(PTS) system
I6H68_RS00050	COG0561	phosphatase activity
I6H68_RS00065	COG0583	DNA-binding transcription factor activity
I6H68_RS00080	COG0745	RESPONSE REGULATOR receiver
I6H68_RS00100	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I6H68_RS00105	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6H68_RS00115	COG3706	GGDEF domain
I6H68_RS00125	COG3546	catalase activity
I6H68_RS00145	COG1307	EDD domain protein, DegV family
I6H68_RS00155	COG0640	Transcriptional regulator
I6H68_RS00160	COG1511	domain protein
I6H68_RS00160	COG1511	domain protein
I6H68_RS00175	COG2188	Transcriptional regulator
I6H68_RS00180	COG2723	6-phospho-beta-galactosidase activity
I6H68_RS00185	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6H68_RS00190	COG0095	Lipoate-protein ligase
I6H68_RS00225	COG1959	2 iron, 2 sulfur cluster binding
I6H68_RS00240	COG4708	membrane
I6H68_RS00265	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6H68_RS00270	COG3715	PTS system
I6H68_RS00275	COG3716	PTS system mannose fructose sorbose family IID component
I6H68_RS00280	COG2188	Transcriptional regulator
I6H68_RS00285	COG2222	sugar isomerase
I6H68_RS00340	COG3048	D-serine ammonia-lyase activity
I6H68_RS00350	COG1136	(ABC) transporter
I6H68_RS00365	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I6H68_RS00365	COG2755	lipolytic protein G-D-S-L family
I6H68_RS00380	COG0586	Pfam SNARE associated Golgi protein
I6H68_RS00385	COG1131	(ABC) transporter
I6H68_RS00400	COG2197	response regulator
I6H68_RS00405	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6H68_RS00410	COG2814	Major facilitator Superfamily
I6H68_RS00420	COG0791	NLP P60 protein
I6H68_RS00430	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6H68_RS00445	COG0357	Ribosomal RNA small subunit methyltransferase G
I6H68_RS00450	COG1475	DNA binding
I6H68_RS00455	COG4481	Protein conserved in bacteria
I6H68_RS00460	COG0012	GTP binding
I6H68_RS00470	COG0517	IMP dehydrogenase activity
I6H68_RS00470	COG0516	GMP reductase activity
I6H68_RS00475	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6H68_RS00480	COG0745	RESPONSE REGULATOR receiver
I6H68_RS00490	COG1686	Belongs to the peptidase S11 family
I6H68_RS00530	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6H68_RS00540	COG0588	phosphoglycerate mutase activity
I6H68_RS00560	COG0406	alpha-ribazole phosphatase activity
I6H68_RS00570	COG1914	H( )-stimulated, divalent metal cation uptake system
I6H68_RS00575	COG1609	Transcriptional regulator
I6H68_RS00585	COG1869	D-ribose catabolic process
I6H68_RS00590	COG4975	Glucose uptake
I6H68_RS00595	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
I6H68_RS00600	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6H68_RS00605	COG3875	lactate racemase activity
I6H68_RS00610	COG1691	(AIR) carboxylase
I6H68_RS00615	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
I6H68_RS00620	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6H68_RS00625	COG1606	tRNA processing
I6H68_RS00635	COG2814	Major facilitator Superfamily
I6H68_RS00645	COG0583	DNA-binding transcription factor activity
I6H68_RS00660	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6H68_RS00665	COG1131	(ABC) transporter
I6H68_RS00675	COG1309	transcriptional regulator
I6H68_RS00680	COG1846	Transcriptional regulator
I6H68_RS00690	COG0242	peptide deformylase activity
I6H68_RS00695	COG0284	orotidine-5'-phosphate decarboxylase activity
I6H68_RS00700	COG0561	phosphatase activity
I6H68_RS00705	COG2261	transglycosylase associated protein
I6H68_RS00720	COG1302	Protein conserved in bacteria
I6H68_RS00735	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6H68_RS00745	COG2357	RelA SpoT domain protein
I6H68_RS00750	COG2376	Dihydroxyacetone kinase
I6H68_RS00755	COG1461	Dihydroxyacetone kinase
I6H68_RS00760	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
I6H68_RS00765	COG1846	Transcriptional regulator
I6H68_RS00770	COG1132	(ABC) transporter
I6H68_RS00775	COG0673	inositol 2-dehydrogenase activity
I6H68_RS00800	COG1174	glycine betaine transport
I6H68_RS00805	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6H68_RS00810	COG1136	(ABC) transporter
I6H68_RS00810	COG0577	efflux transmembrane transporter activity
I6H68_RS00815	COG0488	(ABC) transporter
I6H68_RS00825	COG0697	spore germination
I6H68_RS00840	COG0105	UTP biosynthetic process
I6H68_RS00860	COG0110	maltose O-acetyltransferase activity
I6H68_RS00865	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6H68_RS00870	COG1854	S-ribosylhomocysteine lyase activity
I6H68_RS00875	COG1268	BioY protein
I6H68_RS00885	COG2814	Major facilitator Superfamily
I6H68_RS00895	COG1164	Oligoendopeptidase f
I6H68_RS00905	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6H68_RS00910	COG0549	Belongs to the carbamate kinase family
I6H68_RS00915	COG2235	arginine
I6H68_RS00930	COG1288	antiporter activity
I6H68_RS00935	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6H68_RS00945	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6H68_RS00960	COG0667	Aldo Keto reductase
I6H68_RS00965	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6H68_RS00995	COG1368	sulfuric ester hydrolase activity
I6H68_RS01000	COG0708	Exodeoxyribonuclease III
I6H68_RS01005	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6H68_RS01010	COG2246	polysaccharide biosynthetic process
I6H68_RS01015	COG0463	Glycosyl transferase, family 2
I6H68_RS01025	COG1682	transport, permease protein
I6H68_RS01030	COG1134	teichoic acid transport
I6H68_RS01045	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I6H68_RS01055	COG2814	Major facilitator Superfamily
I6H68_RS01065	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
I6H68_RS01070	COG1268	BioY protein
I6H68_RS01080	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6H68_RS01085	COG1696	Membrane protein involved in D-alanine export
I6H68_RS01090	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6H68_RS01095	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
I6H68_RS01100	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6H68_RS01110	COG4166	transmembrane transport
I6H68_RS01130	COG0534	Mate efflux family protein
I6H68_RS01160	COG1078	dGTPase activity
I6H68_RS01170	COG3343	RNA polymerase activity
I6H68_RS01175	COG0504	CTP synthase activity
I6H68_RS01180	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6H68_RS01185	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I6H68_RS01190	COG0254	rRNA binding
I6H68_RS01200	COG3764	Sortase (surface protein transpeptidase)
I6H68_RS01205	COG1704	LemA family
I6H68_RS01210	COG0501	Belongs to the peptidase M48B family
I6H68_RS01220	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6H68_RS01230	COG0736	holo-[acyl-carrier-protein] synthase activity
I6H68_RS01235	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6H68_RS01245	COG2337	Toxic component of a toxin-antitoxin (TA) module
I6H68_RS01260	COG0039	L-malate dehydrogenase activity
I6H68_RS01265	COG0193	aminoacyl-tRNA hydrolase activity
I6H68_RS01270	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6H68_RS01275	COG2244	polysaccharide biosynthetic process
I6H68_RS01280	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6H68_RS01290	COG1098	S1 RNA binding domain
I6H68_RS01295	COG0037	tRNA processing
I6H68_RS01310	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I6H68_RS01315	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6H68_RS01320	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6H68_RS01360	COG3104	oligopeptide transport
I6H68_RS01365	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I6H68_RS01385	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6H68_RS01395	COG2188	Transcriptional regulator
I6H68_RS01405	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I6H68_RS01425	COG2183	response to ionizing radiation
I6H68_RS01430	COG3091	SprT-like family
I6H68_RS01445	COG3715	PTS system
I6H68_RS01450	COG3716	PTS system mannose fructose sorbose family IID component
I6H68_RS01460	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I6H68_RS01460	COG3933	PFAM sigma-54 factor interaction domain-containing protein
I6H68_RS01475	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6H68_RS01480	COG0588	phosphoglycerate mutase activity
I6H68_RS01485	COG2814	Major facilitator Superfamily
I6H68_RS01490	COG1733	regulation of RNA biosynthetic process
I6H68_RS01500	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I6H68_RS01510	COG0756	dUTP diphosphatase activity
I6H68_RS01515	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I6H68_RS01520	COG4956	integral membrane protein (PIN domain superfamily)
I6H68_RS01525	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6H68_RS01530	COG0215	cysteine-tRNA ligase activity
I6H68_RS01535	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
I6H68_RS01540	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6H68_RS01550	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6H68_RS01560	COG0250	Participates in transcription elongation, termination and antitermination
I6H68_RS01565	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I6H68_RS01570	COG0081	regulation of translation
I6H68_RS01575	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6H68_RS01580	COG0222	ribosome binding
I6H68_RS01585	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6H68_RS01595	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6H68_RS01600	COG2813	Specifically methylates the guanine in position
I6H68_RS01615	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6H68_RS01620	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I6H68_RS01625	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6H68_RS01630	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6H68_RS01635	COG3870	Protein conserved in bacteria
I6H68_RS01640	COG0470	DNA polymerase III
I6H68_RS01645	COG4467	Involved in initiation control of chromosome replication
I6H68_RS01650	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I6H68_RS01660	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6H68_RS01665	COG1214	PFAM Peptidase M22, glycoprotease
I6H68_RS01670	COG1214	PFAM Peptidase M22, glycoprotease
I6H68_RS01670	COG0456	acetyltransferase
I6H68_RS01675	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I6H68_RS01685	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
I6H68_RS01690	COG2502	aspartate--ammonia ligase
I6H68_RS01695	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6H68_RS01700	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6H68_RS01705	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I6H68_RS01710	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6H68_RS01715	COG0047	phosphoribosylformylglycinamidine synthase activity
I6H68_RS01720	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6H68_RS01725	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I6H68_RS01730	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6H68_RS01735	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6H68_RS01740	COG0138	bifunctional purine biosynthesis protein purh
I6H68_RS01745	COG0151	Belongs to the GarS family
I6H68_RS01755	COG4690	dipeptidase activity
I6H68_RS01780	COG0564	pseudouridine synthase activity
I6H68_RS01790	COG1418	mRNA catabolic process
I6H68_RS01795	COG1418	mRNA catabolic process
I6H68_RS01805	COG1278	Cold shock
I6H68_RS01810	COG2966	Psort location CytoplasmicMembrane, score
I6H68_RS01820	COG1940	carbohydrate kinase activity
I6H68_RS01825	COG1316	TRANSCRIPTIONal
I6H68_RS01830	COG0657	acetylesterase activity
I6H68_RS01830	COG2755	lipolytic protein G-D-S-L family
I6H68_RS01840	COG0833	amino acid
I6H68_RS01845	COG1428	Deoxynucleoside kinase
I6H68_RS01850	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I6H68_RS01885	COG4463	regulation of RNA biosynthetic process
I6H68_RS01890	COG0542	response to heat
I6H68_RS01895	COG0085	RNA polymerase activity
I6H68_RS01900	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6H68_RS01905	COG1957	nucleoside hydrolase
I6H68_RS01915	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6H68_RS01920	COG0049	tRNA binding
I6H68_RS01925	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6H68_RS01930	COG0051	transcription antitermination factor activity, RNA binding
I6H68_RS01935	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6H68_RS01940	COG0088	Forms part of the polypeptide exit tunnel
I6H68_RS01945	COG0089	rRNA binding
I6H68_RS01950	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I6H68_RS01955	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6H68_RS01960	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I6H68_RS01965	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I6H68_RS01970	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6H68_RS01975	COG0255	Belongs to the universal ribosomal protein uL29 family
I6H68_RS01985	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I6H68_RS01990	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I6H68_RS01995	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I6H68_RS02000	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6H68_RS02005	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I6H68_RS02010	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I6H68_RS02015	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I6H68_RS02020	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6H68_RS02025	COG1841	ribosomal large subunit assembly
I6H68_RS02030	COG0200	Binds to the 23S rRNA
I6H68_RS02045	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6H68_RS02050	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6H68_RS02055	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6H68_RS02060	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I6H68_RS02065	COG0202	RNA polymerase activity
I6H68_RS02070	COG0203	ribosomal protein L17
I6H68_RS02075	COG1122	ATPase activity
I6H68_RS02080	COG1122	ATPase activity
I6H68_RS02095	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6H68_RS02100	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6H68_RS02120	COG0783	Belongs to the Dps family
I6H68_RS02140	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6H68_RS02150	COG1705	Flagellar rod assembly protein muramidase FlgJ
I6H68_RS02155	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6H68_RS02160	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6H68_RS02170	COG4851	CamS sex pheromone cAM373 precursor
I6H68_RS02180	COG0154	amidase activity
I6H68_RS02185	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6H68_RS02190	COG1597	lipid kinase activity
I6H68_RS02195	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6H68_RS02210	COG1737	Transcriptional regulator
I6H68_RS02215	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
I6H68_RS02225	COG2610	gluconate transmembrane transporter activity
I6H68_RS02240	COG1247	-acetyltransferase
I6H68_RS02245	COG0741	lytic transglycosylase activity
I6H68_RS02255	COG0745	RESPONSE REGULATOR receiver
I6H68_RS02260	COG3850	Histidine kinase
I6H68_RS02260	COG5002	protein histidine kinase activity
I6H68_RS02265	COG0191	fructose-bisphosphate aldolase activity
I6H68_RS02270	COG4975	Glucose uptake
I6H68_RS02275	COG0166	Belongs to the GPI family
I6H68_RS02290	COG0431	NADPH-dependent FMN reductase
I6H68_RS02290	COG1053	succinate dehydrogenase
I6H68_RS02290	COG3976	FMN-binding domain protein
I6H68_RS02300	COG0330	HflC and HflK could
I6H68_RS02320	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6H68_RS02340	COG1132	(ABC) transporter
I6H68_RS02345	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6H68_RS02350	COG1482	cell wall glycoprotein biosynthetic process
I6H68_RS02355	COG3442	glutamine amidotransferase
I6H68_RS02360	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6H68_RS02365	COG1435	thymidine kinase activity
I6H68_RS02370	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6H68_RS02375	COG2890	protein-(glutamine-N5) methyltransferase activity
I6H68_RS02380	COG0009	L-threonylcarbamoyladenylate synthase
I6H68_RS02385	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6H68_RS02390	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I6H68_RS02405	COG0356	it plays a direct role in the translocation of protons across the membrane
I6H68_RS02410	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6H68_RS02415	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I6H68_RS02420	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6H68_RS02425	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I6H68_RS02430	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I6H68_RS02435	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I6H68_RS02440	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I6H68_RS02450	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6H68_RS02460	COG0772	Belongs to the SEDS family
I6H68_RS02465	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6H68_RS02470	COG2011	ABC-type metal ion transport system permease component
I6H68_RS02475	COG1464	Belongs to the NlpA lipoprotein family
I6H68_RS02480	COG1725	Transcriptional regulator
I6H68_RS02485	COG1131	(ABC) transporter
I6H68_RS02500	COG0531	amino acid
I6H68_RS02510	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6H68_RS02520	COG0589	response to stress
I6H68_RS02525	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6H68_RS02530	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6H68_RS02535	COG1956	GAF domain-containing protein
I6H68_RS02540	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
I6H68_RS02545	COG1104	cysteine desulfurase activity
I6H68_RS02550	COG0301	tRNA thio-modification
I6H68_RS02555	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I6H68_RS02560	COG0525	valine-tRNA ligase activity
I6H68_RS02565	COG0285	dihydrofolate synthase activity
I6H68_RS02585	COG0765	amino acid transport
I6H68_RS02590	COG1126	abc transporter atp-binding protein
I6H68_RS02595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6H68_RS02600	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6H68_RS02605	COG0612	Peptidase, M16
I6H68_RS02610	COG0612	Peptidase, M16
I6H68_RS02615	COG0300	oxidoreductase activity
I6H68_RS02625	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6H68_RS02630	COG1058	Belongs to the CinA family
I6H68_RS02630	COG1546	Belongs to the CinA family
I6H68_RS02640	COG1418	mRNA catabolic process
I6H68_RS02645	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I6H68_RS02650	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6H68_RS02655	COG0632	four-way junction helicase activity
I6H68_RS02660	COG2255	four-way junction helicase activity
I6H68_RS02665	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I6H68_RS02670	COG0343	queuine tRNA-ribosyltransferase activity
I6H68_RS02675	COG1862	Preprotein translocase
I6H68_RS02680	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I6H68_RS02685	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6H68_RS02690	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I6H68_RS02695	COG0513	Belongs to the DEAD box helicase family
I6H68_RS02700	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6H68_RS02705	COG4472	Bacterial protein of unknown function (DUF965)
I6H68_RS02710	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6H68_RS02715	COG3906	Belongs to the UPF0473 family
I6H68_RS02720	COG1193	negative regulation of DNA recombination
I6H68_RS02725	COG3118	belongs to the thioredoxin family
I6H68_RS02730	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6H68_RS02735	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I6H68_RS02740	COG0668	transmembrane transport
I6H68_RS02755	COG0028	Belongs to the TPP enzyme family
I6H68_RS02760	COG0006	proline dipeptidase activity
I6H68_RS02765	COG1609	Transcriptional regulator
I6H68_RS02770	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6H68_RS02780	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6H68_RS02785	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6H68_RS02790	COG1335	isochorismatase
I6H68_RS02795	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6H68_RS02815	COG0217	transcriptional regulatory protein
I6H68_RS02825	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6H68_RS02830	COG1459	type II secretion system
I6H68_RS02835	COG4537	Required for transformation and DNA binding
I6H68_RS02855	COG0827	DNA restriction-modification system
I6H68_RS02860	COG1113	amino acid transport
I6H68_RS02870	COG4470	Protein conserved in bacteria
I6H68_RS02875	COG0647	UMP catabolic process
I6H68_RS02885	COG0586	Pfam SNARE associated Golgi protein
I6H68_RS02965	COG1234	tRNA 3'-trailer cleavage
I6H68_RS02970	COG1393	Belongs to the ArsC family
I6H68_RS02975	COG4862	establishment of competence for transformation
I6H68_RS02990	COG2357	RelA SpoT domain protein
I6H68_RS02995	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6H68_RS03000	COG0564	pseudouridine synthase activity
I6H68_RS03005	COG2239	Acts as a magnesium transporter
I6H68_RS03010	COG3142	Participates in the control of copper homeostasis
I6H68_RS03015	COG2706	6-phosphogluconolactonase activity
I6H68_RS03025	COG0628	permease
I6H68_RS03035	COG1674	ftsk spoiiie
I6H68_RS03045	COG2001	Belongs to the MraZ family
I6H68_RS03050	COG0275	rRNA processing
I6H68_RS03060	COG0768	penicillin binding
I6H68_RS03065	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6H68_RS03070	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6H68_RS03075	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6H68_RS03080	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6H68_RS03085	COG0849	cell division
I6H68_RS03090	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6H68_RS03105	COG3599	regulation of cell shape
I6H68_RS03110	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6H68_RS03120	COG0494	nUDIX hydrolase
I6H68_RS03130	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6H68_RS03135	COG1104	cysteine desulfurase activity
I6H68_RS03145	COG0482	sulfurtransferase activity
I6H68_RS03160	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6H68_RS03165	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6H68_RS03170	COG0628	permease
I6H68_RS03175	COG1349	DNA-binding transcription factor activity
I6H68_RS03180	COG1105	Belongs to the carbohydrate kinase PfkB family
I6H68_RS03185	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6H68_RS03185	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6H68_RS03185	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6H68_RS03200	COG5503	Protein of unknown function (DUF1447)
I6H68_RS03210	COG0242	peptide deformylase activity
I6H68_RS03215	COG4476	Belongs to the UPF0223 family
I6H68_RS03220	COG0483	inositol monophosphate 1-phosphatase activity
I6H68_RS03225	COG1217	gtp-binding protein TYPA
I6H68_RS03230	COG0772	Belongs to the SEDS family
I6H68_RS03235	COG4471	UPF0298 protein
I6H68_RS03240	COG0742	ribosomal rna small subunit methyltransferase
I6H68_RS03245	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I6H68_RS03250	COG1596	polysaccharide export
I6H68_RS03250	COG1555	photosystem II stabilization
I6H68_RS03255	COG2131	deaminase
I6H68_RS03260	COG2333	competence protein COMEC
I6H68_RS03260	COG0658	competence protein
I6H68_RS03265	COG1466	dna polymerase III delta subunit
I6H68_RS03270	COG0268	Binds directly to 16S ribosomal RNA
I6H68_RS03275	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I6H68_RS03290	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6H68_RS03295	COG0544	peptidyl-prolyl cis-trans isomerase activity
I6H68_RS03300	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I6H68_RS03305	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I6H68_RS03320	COG0765	amino acid transport
I6H68_RS03325	COG1126	abc transporter atp-binding protein
I6H68_RS03330	COG0322	excinuclease ABC activity
I6H68_RS03335	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I6H68_RS03345	COG1234	tRNA 3'-trailer cleavage
I6H68_RS03350	COG0300	oxidoreductase activity
I6H68_RS03355	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
I6H68_RS03355	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6H68_RS03360	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6H68_RS03375	COG0697	spore germination
I6H68_RS03385	COG2233	PERMEase
I6H68_RS03390	COG2264	protein methyltransferase activity
I6H68_RS03395	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6H68_RS03400	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6H68_RS03405	COG1490	D-aminoacyl-tRNA deacylase activity
I6H68_RS03420	COG0124	histidyl-tRNA synthetase
I6H68_RS03425	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6H68_RS03430	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6H68_RS03445	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
I6H68_RS03450	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I6H68_RS03455	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I6H68_RS03460	COG1610	YqeY-like protein
I6H68_RS03465	COG1702	phosphate starvation-inducible protein PhoH
I6H68_RS03470	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I6H68_RS03480	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6H68_RS03485	COG1381	Involved in DNA repair and RecF pathway recombination
I6H68_RS03490	COG0752	glycyl-tRNA synthetase alpha subunit
I6H68_RS03495	COG0751	glycine-tRNA ligase activity
I6H68_RS03500	COG0358	DNA primase activity
I6H68_RS03505	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6H68_RS03510	COG2384	SAM-dependent methyltransferase
I6H68_RS03515	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6H68_RS03520	COG0542	response to heat
I6H68_RS03530	COG0587	DNA-directed DNA polymerase activity
I6H68_RS03535	COG0205	6-phosphofructokinase activity
I6H68_RS03550	COG2707	UPF0756 membrane protein
I6H68_RS03555	COG2996	Protein conserved in bacteria
I6H68_RS03570	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I6H68_RS03575	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6H68_RS03580	COG1187	pseudouridine synthase activity
I6H68_RS03590	COG0514	ATP-dependent DNA helicase (RecQ)
I6H68_RS03600	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6H68_RS03605	COG0539	negative regulation of cytoplasmic translation
I6H68_RS03620	COG0457	Tetratricopeptide repeat
I6H68_RS03635	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6H68_RS03640	COG0617	tRNA 3'-terminal CCA addition
I6H68_RS03645	COG0488	(ABC) transporter
I6H68_RS03650	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I6H68_RS03655	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I6H68_RS03660	COG0765	amino acid transport
I6H68_RS03665	COG1126	abc transporter atp-binding protein
I6H68_RS03670	COG1307	EDD domain protein, DegV family
I6H68_RS03675	COG2755	lipolytic protein G-D-S-L family
I6H68_RS03685	COG4479	Belongs to the UPF0346 family
I6H68_RS03690	COG0793	Belongs to the peptidase S41A family
I6H68_RS03690	COG3409	Peptidoglycan-binding domain 1 protein
I6H68_RS03695	COG1757	Na H antiporter
I6H68_RS03700	COG1393	Belongs to the ArsC family
I6H68_RS03705	COG0531	amino acid
I6H68_RS03710	COG0519	Catalyzes the synthesis of GMP from XMP
I6H68_RS03715	COG0105	UTP biosynthetic process
I6H68_RS03740	COG0583	DNA-binding transcription factor activity
I6H68_RS03755	COG0367	asparagine synthase
I6H68_RS03820	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6H68_RS03825	COG0758	DNA mediated transformation
I6H68_RS03830	COG1609	Transcriptional regulator
I6H68_RS03845	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6H68_RS03850	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6H68_RS03855	COG4974	Belongs to the 'phage' integrase family
I6H68_RS03860	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
I6H68_RS03865	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
I6H68_RS03880	COG0187	DNA topoisomerase II activity
I6H68_RS03895	COG1227	inorganic diphosphatase activity
I6H68_RS03900	COG1929	Belongs to the glycerate kinase type-1 family
I6H68_RS03930	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6H68_RS03935	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6H68_RS03940	COG1307	EDD domain protein, DegV family
I6H68_RS03950	COG1293	RNA-binding protein homologous to eukaryotic snRNP
I6H68_RS03965	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
I6H68_RS03970	COG0564	pseudouridine synthase activity
I6H68_RS03975	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I6H68_RS03980	COG2759	Belongs to the formate--tetrahydrofolate ligase family
I6H68_RS03990	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6H68_RS03995	COG0116	Belongs to the methyltransferase superfamily
I6H68_RS04005	COG3599	regulation of cell shape
I6H68_RS04010	COG4474	Belongs to the UPF0398 family
I6H68_RS04015	COG3331	DNA recombination
I6H68_RS04020	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6H68_RS04025	COG3935	DnaD domain protein
I6H68_RS04055	COG1304	FMN binding
I6H68_RS04095	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
I6H68_RS04095	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6H68_RS04100	COG0561	phosphatase activity
I6H68_RS04105	COG1942	4-Oxalocrotonate Tautomerase
I6H68_RS04115	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6H68_RS04145	COG2801	Transposase and inactivated derivatives
I6H68_RS04190	COG2261	transglycosylase associated protein
I6H68_RS04200	COG1028	Short-chain dehydrogenase reductase Sdr
I6H68_RS04220	COG2155	Conserved Protein
I6H68_RS04225	COG0484	heat shock protein binding
I6H68_RS04230	COG0443	Heat shock 70 kDa protein
I6H68_RS04235	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I6H68_RS04240	COG1420	regulation of RNA biosynthetic process
I6H68_RS04245	COG0196	riboflavin kinase activity
I6H68_RS04250	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6H68_RS04255	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6H68_RS04260	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I6H68_RS04270	COG2740	Nucleic-acid-binding protein implicated in transcription termination
I6H68_RS04275	COG0195	Participates in both transcription termination and antitermination
I6H68_RS04280	COG0779	Required for maturation of 30S ribosomal subunits
I6H68_RS04285	COG2176	DNA-directed DNA polymerase activity
I6H68_RS04290	COG0442	prolyl-tRNA aminoacylation
I6H68_RS04295	COG0750	zinc metalloprotease
I6H68_RS04300	COG4589	Belongs to the CDS family
I6H68_RS04305	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6H68_RS04310	COG0233	cytoplasmic translational termination
I6H68_RS04315	COG0528	UMP kinase activity
I6H68_RS04320	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I6H68_RS04325	COG0052	Belongs to the universal ribosomal protein uS2 family
I6H68_RS04335	COG2827	Endonuclease containing a URI domain
I6H68_RS04340	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I6H68_RS04345	COG0204	Acyl-transferase
I6H68_RS04350	COG3763	UPF0154 protein
I6H68_RS04355	COG4224	UPF0291 protein
I6H68_RS04360	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6H68_RS04370	COG3425	synthase
I6H68_RS04375	COG1113	amino acid transport
I6H68_RS04575	COG0629	single-stranded DNA binding
I6H68_RS04635	COG1396	sequence-specific DNA binding
I6H68_RS04660	COG4974	Belongs to the 'phage' integrase family
I6H68_RS04665	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I6H68_RS04670	COG0825	malonyl-CoA metabolic process
I6H68_RS04675	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I6H68_RS04680	COG0439	Biotin carboxylase
I6H68_RS04690	COG0511	ligase activity, forming carbon-carbon bonds
I6H68_RS04695	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6H68_RS04700	COG1028	Short-chain dehydrogenase reductase Sdr
I6H68_RS04715	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6H68_RS04720	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6H68_RS04730	COG0393	Putative heavy-metal-binding
I6H68_RS04735	COG0335	large ribosomal subunit rRNA binding
I6H68_RS04740	COG0336	Belongs to the RNA methyltransferase TrmD family
I6H68_RS04745	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6H68_RS04750	COG0228	four-way junction DNA binding
I6H68_RS04755	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6H68_RS04760	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
I6H68_RS04765	COG0552	protein localization to endoplasmic reticulum
I6H68_RS04770	COG1196	nuclear chromosome segregation
I6H68_RS04775	COG0571	ribonuclease III activity
I6H68_RS04780	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6H68_RS04785	COG0416	fatty acid biosynthetic process
I6H68_RS04790	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6H68_RS04800	COG1302	Protein conserved in bacteria
I6H68_RS04805	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6H68_RS04815	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6H68_RS04820	COG1162	GTPase activity
I6H68_RS04830	COG0631	protein serine/threonine phosphatase activity
I6H68_RS04835	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6H68_RS04835	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6H68_RS04840	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6H68_RS04845	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6H68_RS04850	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6H68_RS04855	COG1758	RNA polymerase activity
I6H68_RS04860	COG0194	GDP metabolic process
I6H68_RS04870	COG0497	DNA recombination
I6H68_RS04875	COG1438	arginine binding
I6H68_RS04880	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
I6H68_RS04890	COG1722	exodeoxyribonuclease VII activity
I6H68_RS04895	COG1570	exodeoxyribonuclease VII activity
I6H68_RS04900	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6H68_RS04905	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6H68_RS04910	COG1302	Protein conserved in bacteria
I6H68_RS04915	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6H68_RS04920	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6H68_RS04930	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I6H68_RS04980	COG0789	Transcriptional regulator
I6H68_RS04985	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
I6H68_RS04990	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I6H68_RS04995	COG0584	glycerophosphoryl diester phosphodiesterase
I6H68_RS05005	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6H68_RS05010	COG1940	carbohydrate kinase activity
I6H68_RS05020	COG0705	Rhomboid family
I6H68_RS05025	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6H68_RS05030	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6H68_RS05035	COG0768	penicillin binding
I6H68_RS05045	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6H68_RS05050	COG0572	uridine kinase
I6H68_RS05055	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6H68_RS05060	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6H68_RS05060	COG0072	phenylalanine-tRNA ligase activity
I6H68_RS05065	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I6H68_RS05070	COG1733	regulation of RNA biosynthetic process
I6H68_RS05080	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6H68_RS05085	COG1254	Belongs to the acylphosphatase family
I6H68_RS05090	COG0706	membrane insertase activity
I6H68_RS05095	COG5002	protein histidine kinase activity
I6H68_RS05100	COG0745	RESPONSE REGULATOR receiver
I6H68_RS05105	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I6H68_RS05110	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I6H68_RS05115	COG1399	metal-binding, possibly nucleic acid-binding protein
I6H68_RS05120	COG1323	Belongs to the UPF0348 family
I6H68_RS05125	COG2226	methyltransferase
I6H68_RS05130	COG0799	negative regulation of ribosome biogenesis
I6H68_RS05135	COG1713	HD superfamily hydrolase involved in NAD metabolism
I6H68_RS05140	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I6H68_RS05145	COG1534	Rna-binding protein
I6H68_RS05150	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I6H68_RS05165	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I6H68_RS05170	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6H68_RS05175	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I6H68_RS05180	COG1346	cytolysis
I6H68_RS05185	COG1380	Effector of murein hydrolase LrgA
I6H68_RS05190	COG3279	Response regulator of the LytR AlgR family
I6H68_RS05195	COG3275	phosphorelay sensor kinase activity
I6H68_RS05200	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6H68_RS05205	COG1484	DNA-dependent DNA replication
I6H68_RS05215	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6H68_RS05220	COG0237	dephospho-CoA kinase activity
I6H68_RS05225	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6H68_RS05230	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6H68_RS05230	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6H68_RS05235	COG0670	Belongs to the BI1 family
I6H68_RS05240	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6H68_RS05245	COG1674	ftsk spoiiie
I6H68_RS05250	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6H68_RS05260	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6H68_RS05265	COG4473	ABC transporter
I6H68_RS05270	COG1131	(ABC) transporter
I6H68_RS05275	COG0537	adenosine 5'-monophosphoramidase activity
I6H68_RS05285	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6H68_RS05290	COG3481	metal-dependent phosphohydrolase, HD sub domain
I6H68_RS05295	COG4717	serine-type aminopeptidase activity
I6H68_RS05300	COG0420	3'-5' exonuclease activity
I6H68_RS05305	COG3679	Belongs to the UPF0342 family
I6H68_RS05310	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6H68_RS05315	COG1438	arginine binding
I6H68_RS05325	COG0018	arginyl-trna synthetase
I6H68_RS05330	COG0667	Aldo Keto reductase
I6H68_RS05335	COG0561	phosphatase activity
I6H68_RS05350	COG0531	amino acid
I6H68_RS05375	COG0367	asparagine synthase
I6H68_RS05410	COG0561	phosphatase activity
I6H68_RS05415	COG1428	Deoxynucleoside kinase
I6H68_RS05420	COG0589	response to stress
I6H68_RS05425	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6H68_RS05430	COG1187	pseudouridine synthase activity
I6H68_RS05435	COG2244	polysaccharide biosynthetic process
I6H68_RS05440	COG0495	leucyl-tRNA aminoacylation
I6H68_RS05445	COG0671	phosphoesterase, PA-phosphatase related
I6H68_RS05450	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I6H68_RS05455	COG2814	Major facilitator Superfamily
I6H68_RS05460	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6H68_RS05470	COG0028	Belongs to the TPP enzyme family
I6H68_RS05600	COG0438	transferase activity, transferring glycosyl groups
I6H68_RS05605	COG0438	transferase activity, transferring glycosyl groups
I6H68_RS05610	COG0596	Alpha beta hydrolase
I6H68_RS05630	COG0542	response to heat
I6H68_RS05640	COG0730	response to heat
I6H68_RS05645	COG1368	sulfuric ester hydrolase activity
I6H68_RS05650	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I6H68_RS05655	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I6H68_RS05660	COG0628	permease
I6H68_RS05665	COG3557	Belongs to the UPF0374 family
I6H68_RS05670	COG2137	regulation of response to DNA damage stimulus
I6H68_RS05675	COG0716	FMN binding
I6H68_RS05680	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6H68_RS05685	COG2309	aminopeptidase activity
I6H68_RS05690	COG0516	GMP reductase activity
I6H68_RS05710	COG1316	TRANSCRIPTIONal
I6H68_RS05715	COG0513	Belongs to the DEAD box helicase family
I6H68_RS05720	COG0673	inositol 2-dehydrogenase activity
I6H68_RS05735	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I6H68_RS05745	COG0531	amino acid
I6H68_RS05780	COG0728	peptidoglycan biosynthetic process
I6H68_RS05790	COG0562	UDP-galactopyranose mutase
I6H68_RS05800	COG1216	Glycosyl transferase, family 2
I6H68_RS05800	COG1442	glycosyl transferase family 8
I6H68_RS05805	COG0438	transferase activity, transferring glycosyl groups
I6H68_RS05825	COG4464	protein tyrosine phosphatase activity
I6H68_RS05830	COG0489	protein tyrosine kinase activity
I6H68_RS05850	COG0514	ATP-dependent DNA helicase (RecQ)
I6H68_RS05855	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6H68_RS05860	COG0352	thiamine-phosphate diphosphorylase activity
I6H68_RS05865	COG0351	phosphomethylpyrimidine kinase
I6H68_RS05870	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
I6H68_RS05890	COG2095	MarC family integral membrane protein
I6H68_RS05900	COG0789	Transcriptional regulator
I6H68_RS05905	COG4221	oxidoreductase activity
I6H68_RS05915	COG3475	LICD family
I6H68_RS05960	COG0300	oxidoreductase activity
I6H68_RS05970	COG2252	PERMEase
I6H68_RS05975	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6H68_RS05995	COG2801	Transposase and inactivated derivatives
I6H68_RS06015	COG1695	Transcriptional regulator
I6H68_RS06020	COG3479	Phenolic acid decarboxylase
I6H68_RS06025	COG0719	Fe-S assembly protein
I6H68_RS06030	COG0822	iron-sulfur transferase activity
I6H68_RS06035	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6H68_RS06040	COG0719	Fe-S assembly protein
I6H68_RS06045	COG0396	ATPase activity
I6H68_RS06055	COG1328	CTP reductase activity
I6H68_RS06060	COG1914	H( )-stimulated, divalent metal cation uptake system
I6H68_RS06065	COG1011	Hydrolase
I6H68_RS06085	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6H68_RS06090	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6H68_RS06100	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
I6H68_RS06105	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6H68_RS06125	COG0802	atpase or kinase
I6H68_RS06130	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6H68_RS06135	COG0561	phosphatase activity
I6H68_RS06150	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I6H68_RS06155	COG0557	exoribonuclease II activity
I6H68_RS06160	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6H68_RS06165	COG0148	phosphopyruvate hydratase activity
I6H68_RS06170	COG0149	triose-phosphate isomerase activity
I6H68_RS06175	COG0126	phosphoglycerate kinase activity
I6H68_RS06185	COG2390	Transcriptional regulator
I6H68_RS06190	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I6H68_RS06200	COG0740	serine-type endopeptidase activity
I6H68_RS06210	COG1388	LysM domain
I6H68_RS06210	COG1705	Flagellar rod assembly protein muramidase FlgJ
I6H68_RS06215	COG1481	regulation of sporulation
I6H68_RS06220	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I6H68_RS06225	COG1660	Displays ATPase and GTPase activities
I6H68_RS06230	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6H68_RS06235	COG0556	nucleotide-excision repair
I6H68_RS06245	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6H68_RS06250	COG0492	ferredoxin-NADP+ reductase activity
I6H68_RS06255	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6H68_RS06260	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I6H68_RS06265	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I6H68_RS06270	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
I6H68_RS06275	COG1950	PFAM Membrane protein of
I6H68_RS06285	COG0704	Plays a role in the regulation of phosphate uptake
I6H68_RS06290	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6H68_RS06300	COG0581	inorganic phosphate transmembrane transporter activity
I6H68_RS06305	COG0573	inorganic phosphate transmembrane transporter activity
I6H68_RS06315	COG5002	protein histidine kinase activity
I6H68_RS06320	COG0745	RESPONSE REGULATOR receiver
I6H68_RS06330	COG0653	protein targeting
I6H68_RS06340	COG1040	competence protein
I6H68_RS06345	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
I6H68_RS06350	COG1739	Uncharacterized protein family UPF0029
I6H68_RS06355	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6H68_RS06360	COG0531	amino acid
I6H68_RS06365	COG0459	protein refolding
I6H68_RS06370	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6H68_RS06385	COG0308	aminopeptidase N
I6H68_RS06390	COG2814	Major facilitator Superfamily
I6H68_RS06410	COG0519	Catalyzes the synthesis of GMP from XMP
I6H68_RS06410	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6H68_RS06425	COG2217	Heavy metal translocating P-type atpase
I6H68_RS06435	COG1072	(Pantothenic acid kinase))
I6H68_RS06445	COG0028	Belongs to the TPP enzyme family
I6H68_RS06450	COG3973	AAA domain
I6H68_RS06455	COG0588	phosphoglycerate mutase activity
I6H68_RS06460	COG0531	amino acid
I6H68_RS06465	COG0588	phosphoglycerate mutase activity
I6H68_RS06470	COG4608	Belongs to the ABC transporter superfamily
I6H68_RS06475	COG0444	Belongs to the ABC transporter superfamily
I6H68_RS06480	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6H68_RS06485	COG0601	transmembrane transport
I6H68_RS06490	COG4166	transmembrane transport
I6H68_RS06495	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6H68_RS06510	COG0765	amino acid transport
I6H68_RS06515	COG0765	amino acid transport
I6H68_RS06520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6H68_RS06525	COG1126	abc transporter atp-binding protein
I6H68_RS06540	COG0735	belongs to the Fur family
I6H68_RS06545	COG0194	GDP metabolic process
I6H68_RS06560	COG0531	amino acid
I6H68_RS06565	COG2252	PERMEase
I6H68_RS06570	COG2936	dipeptidyl-peptidase activity
I6H68_RS06575	COG2267	carboxylic ester hydrolase activity
I6H68_RS06580	COG0656	L-ascorbic acid biosynthetic process
I6H68_RS06585	COG0488	(ABC) transporter
I6H68_RS06605	COG3118	belongs to the thioredoxin family
I6H68_RS06610	COG0861	Integral membrane protein TerC family
I6H68_RS06635	COG1368	sulfuric ester hydrolase activity
I6H68_RS06640	COG0492	ferredoxin-NADP+ reductase activity
I6H68_RS06645	COG1957	nucleoside hydrolase
I6H68_RS06650	COG0025	NhaP-type Na H and K H
I6H68_RS06670	COG0586	Pfam SNARE associated Golgi protein
I6H68_RS06675	COG1376	ErfK ybiS ycfS ynhG family protein
I6H68_RS06685	COG2084	Dehydrogenase
I6H68_RS06695	COG0564	pseudouridine synthase activity
I6H68_RS06700	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
I6H68_RS06705	COG2188	Transcriptional regulator
I6H68_RS06710	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6H68_RS06730	COG4989	oxidoreductase activity
I6H68_RS06735	COG1253	flavin adenine dinucleotide binding
I6H68_RS06740	COG0561	phosphatase activity
I6H68_RS06745	COG1780	Probably involved in ribonucleotide reductase function
I6H68_RS06750	COG2365	Tyrosine phosphatase family
I6H68_RS06755	COG2365	Tyrosine phosphatase family
I6H68_RS06765	COG1295	ribonuclease BN
I6H68_RS06770	COG2814	Major facilitator Superfamily
I6H68_RS06775	COG0735	belongs to the Fur family
I6H68_RS06780	COG0280	phosphate acetyltransferase
I6H68_RS06785	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6H68_RS06790	COG0363	glucosamine-6-phosphate deaminase activity
I6H68_RS06800	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6H68_RS06810	COG1116	anion transmembrane transporter activity
I6H68_RS06820	COG2910	NAD(P)H-binding
I6H68_RS06825	COG2409	Drug exporters of the RND superfamily
I6H68_RS06825	COG1033	growth of symbiont in host cell
I6H68_RS06830	COG1309	transcriptional regulator
I6H68_RS06855	COG1215	transferase activity, transferring glycosyl groups
I6H68_RS06870	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
I6H68_RS06875	COG1053	succinate dehydrogenase
I6H68_RS06880	COG0167	dihydroorotate dehydrogenase activity
I6H68_RS06885	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6H68_RS06890	COG0505	Belongs to the CarA family
I6H68_RS06895	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6H68_RS06900	COG0540	Belongs to the ATCase OTCase family
I6H68_RS06905	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I6H68_RS06910	COG0561	phosphatase activity
I6H68_RS06925	COG2855	membrane
I6H68_RS06930	COG0583	DNA-binding transcription factor activity
I6H68_RS06950	COG2252	PERMEase
I6H68_RS06955	COG3590	peptidase
I6H68_RS06965	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6H68_RS06970	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6H68_RS06990	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6H68_RS06995	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6H68_RS07005	COG2801	Transposase and inactivated derivatives
I6H68_RS07015	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I6H68_RS07020	COG2365	Tyrosine phosphatase family
I6H68_RS07025	COG1902	pentaerythritol trinitrate reductase activity
I6H68_RS07035	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6H68_RS07060	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
I6H68_RS07070	COG4869	propanediol catabolic process
I6H68_RS07140	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6H68_RS07145	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6H68_RS07155	COG1121	(ABC) transporter
I6H68_RS07160	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6H68_RS07170	COG1573	uracil-dna glycosylase
I6H68_RS07180	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6H68_RS07190	COG2723	6-phospho-beta-galactosidase activity
I6H68_RS07195	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6H68_RS07200	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6H68_RS07205	COG2188	Transcriptional regulator
I6H68_RS07215	COG4120	Belongs to the binding-protein-dependent transport system permease family
I6H68_RS07220	COG3842	ATPase activity
I6H68_RS07230	COG0477	Major facilitator Superfamily
I6H68_RS07250	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I6H68_RS07255	COG4466	Protein conserved in bacteria
I6H68_RS07260	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6H68_RS07270	COG0084	hydrolase, TatD family'
I6H68_RS07275	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6H68_RS07275	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6H68_RS07280	COG1801	Protein of unknown function DUF72
I6H68_RS07290	COG1983	PspC domain protein
I6H68_RS07315	COG3973	AAA domain
I6H68_RS07325	COG3321	synthase
I6H68_RS07325	COG0604	alcohol dehydrogenase
I6H68_RS07330	COG0583	DNA-binding transcription factor activity
I6H68_RS07335	COG1811	Na channel or pump
I6H68_RS07345	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
I6H68_RS07355	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6H68_RS07360	COG1125	glycine betaine transport
I6H68_RS07360	COG0517	IMP dehydrogenase activity
I6H68_RS07365	COG1174	glycine betaine transport
I6H68_RS07370	COG0402	S-adenosylhomocysteine deaminase activity
I6H68_RS07400	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6H68_RS07420	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6H68_RS07435	COG0351	phosphomethylpyrimidine kinase
I6H68_RS07455	COG0438	transferase activity, transferring glycosyl groups
I6H68_RS07460	COG0697	spore germination
I6H68_RS07465	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6H68_RS07470	COG2017	converts alpha-aldose to the beta-anomer
I6H68_RS07495	COG1442	glycosyl transferase family 8
I6H68_RS07505	COG1827	regulation of RNA biosynthetic process
I6H68_RS07510	COG0477	Major facilitator Superfamily
I6H68_RS07530	COG0114	fumarate hydratase activity
I6H68_RS07535	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
I6H68_RS07540	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6H68_RS07545	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I6H68_RS07560	COG2190	(PTS) system
I6H68_RS07560	COG2211	Major facilitator Superfamily
I6H68_RS07565	COG2017	converts alpha-aldose to the beta-anomer
I6H68_RS07570	COG1609	Transcriptional regulator
I6H68_RS07580	COG2222	sugar isomerase
I6H68_RS07585	COG3716	PTS system mannose fructose sorbose family IID component
I6H68_RS07590	COG3715	PTS system
I6H68_RS07605	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I6H68_RS07605	COG3933	PFAM sigma-54 factor interaction domain-containing protein
I6H68_RS07610	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
I6H68_RS07620	COG3842	ATPase activity
I6H68_RS07630	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6H68_RS07635	COG0235	Class ii aldolase
I6H68_RS07640	COG4806	L-rhamnose isomerase
I6H68_RS07645	COG3254	rhamnose metabolic process
I6H68_RS07650	COG1070	Carbohydrate kinase
I6H68_RS07655	COG2814	Major facilitator Superfamily
I6H68_RS07660	COG2207	Transcriptional regulator
I6H68_RS07660	COG1609	Transcriptional regulator
I6H68_RS07680	COG1297	OPT oligopeptide transporter protein
I6H68_RS07695	COG2160	L-arabinose isomerase activity
I6H68_RS07720	COG3069	C4-dicarboxylate transmembrane transporter activity
I6H68_RS07730	COG2188	Transcriptional regulator
I6H68_RS07735	COG1609	Transcriptional regulator
I6H68_RS07745	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6H68_RS07750	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6H68_RS07765	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
I6H68_RS07780	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I6H68_RS07790	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6H68_RS07795	COG3716	PTS system mannose fructose sorbose family IID component
I6H68_RS07805	COG1285	pathogenesis
I6H68_RS07820	COG4876	unkown
I6H68_RS07825	COG1028	Short-chain dehydrogenase reductase Sdr
I6H68_RS07835	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
I6H68_RS07840	COG3684	Belongs to the aldolase LacD family
I6H68_RS07845	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6H68_RS07845	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6H68_RS07845	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6H68_RS07855	COG1737	Transcriptional regulator
I6H68_RS07865	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I6H68_RS07870	COG0527	aspartate kinase activity
I6H68_RS07880	COG2171	N-acyltransferase activity
I6H68_RS07885	COG1473	amidohydrolase
I6H68_RS07890	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6H68_RS07895	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I6H68_RS07900	COG0436	Aminotransferase
I6H68_RS07905	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6H68_RS07910	COG2814	Major facilitator Superfamily
I6H68_RS07915	COG4932	domain protein
I6H68_RS07915	COG1388	LysM domain
I6H68_RS07925	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6H68_RS07970	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I6H68_RS07975	COG0667	Aldo Keto reductase
I6H68_RS07980	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6H68_RS08005	COG2723	6-phospho-beta-galactosidase activity
I6H68_RS08010	COG1215	transferase activity, transferring glycosyl groups
I6H68_RS08025	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6H68_RS08050	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6H68_RS08145	COG1970	mechanosensitive ion channel activity
I6H68_RS08235	COG2261	transglycosylase associated protein
I6H68_RS08250	COG2814	Major facilitator Superfamily
I6H68_RS08280	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I6H68_RS08305	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6H68_RS08335	COG1114	Component of the transport system for branched-chain amino acids
I6H68_RS08370	COG0745	RESPONSE REGULATOR receiver
I6H68_RS08395	COG2003	Belongs to the UPF0758 family
I6H68_RS08430	COG3940	Belongs to the glycosyl hydrolase 43 family
I6H68_RS08440	COG1846	Transcriptional regulator
I6H68_RS08460	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6H68_RS08465	COG2217	Heavy metal translocating P-type atpase
I6H68_RS08510	COG3394	polysaccharide catabolic process
I6H68_RS08515	COG1263	PTS System
I6H68_RS08515	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6H68_RS08525	COG2190	(PTS) system
I6H68_RS08530	COG1063	alcohol dehydrogenase
I6H68_RS08540	COG0583	DNA-binding transcription factor activity
I6H68_RS08545	COG1028	Short-chain dehydrogenase reductase Sdr
I6H68_RS08585	COG1725	Transcriptional regulator
I6H68_RS08590	COG1131	(ABC) transporter
I6H68_RS08600	COG0656	L-ascorbic acid biosynthetic process
I6H68_RS08605	COG4221	oxidoreductase activity
I6H68_RS08610	COG0110	maltose O-acetyltransferase activity
I6H68_RS08615	COG0583	DNA-binding transcription factor activity
I6H68_RS08630	COG1914	H( )-stimulated, divalent metal cation uptake system
I6H68_RS08655	COG0584	glycerophosphoryl diester phosphodiesterase
I6H68_RS08660	COG1301	dicarboxylic acid transport
I6H68_RS08670	COG1272	protein, Hemolysin III
I6H68_RS08680	COG2200	EAL domain
I6H68_RS08685	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6H68_RS08695	COG2076	Multidrug Resistance protein
I6H68_RS08715	COG0640	Transcriptional regulator
I6H68_RS08720	COG0431	NADPH-dependent FMN reductase
I6H68_RS08725	COG1028	Short-chain dehydrogenase reductase Sdr
I6H68_RS08730	COG0656	L-ascorbic acid biosynthetic process
I6H68_RS08735	COG1733	regulation of RNA biosynthetic process
I6H68_RS08740	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6H68_RS08760	COG1136	(ABC) transporter
I6H68_RS08775	COG0488	(ABC) transporter
I6H68_RS08790	COG2814	Major facilitator Superfamily
I6H68_RS08795	COG0305	Participates in initiation and elongation during chromosome replication
I6H68_RS08800	COG0359	binds to the 23S rRNA
I6H68_RS08810	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6H68_RS08815	COG0629	single-stranded DNA binding
I6H68_RS08820	COG0360	Binds together with S18 to 16S ribosomal RNA
I6H68_RS08830	COG0187	DNA topoisomerase II activity
I6H68_RS08835	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6H68_RS08840	COG2501	S4 domain
I6H68_RS08845	COG0592	DNA-directed DNA polymerase activity
I6H68_RS08850	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6H68_RS08855	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I6H68_RS08860	COG0594	ribonuclease P activity
I6H68_RS08865	COG0706	membrane insertase activity
I6H68_RS08870	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I6H68_RS08875	COG0445	tRNA wobble uridine modification
I6H68_RS08880	COG3022	response to hydroperoxide
I6H68_RS08890	COG0537	adenosine 5'-monophosphoramidase activity
I6H68_RS08895	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6H68_RS08900	COG1757	Na H antiporter
I6H68_RS08905	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
I6H68_RS08905	COG2755	lipolytic protein G-D-S-L family
I6H68_RS08910	COG0519	Catalyzes the synthesis of GMP from XMP
I6H68_RS08925	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
I6H68_RS08930	COG1074	ATP-dependent DNA helicase activity
I6H68_RS08935	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
I6H68_RS08960	COG1619	proteins homologs of microcin C7 resistance protein MccF
I6H68_RS08975	COG1695	Transcriptional regulator
I6H68_RS08980	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6H68_RS08990	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6H68_RS08990	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6H68_RS09000	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6H68_RS09000	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6H68_RS09005	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I6H68_RS09010	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6H68_RS09010	COG1263	PTS System
I6H68_RS09010	COG2190	(PTS) system