locus-tag	class	description
AY601_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AY601_RS00010	COG4771	TonB-dependent receptor
AY601_RS00020	COG2365	Tyrosine phosphatase family
AY601_RS00050	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
AY601_RS00115	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AY601_RS00125	COG0126	phosphoglycerate kinase activity
AY601_RS00130	COG2001	Belongs to the MraZ family
AY601_RS00135	COG0275	rRNA processing
AY601_RS00150	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AY601_RS00155	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AY601_RS00160	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AY601_RS00165	COG0772	Belongs to the SEDS family
AY601_RS00170	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AY601_RS00175	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AY601_RS00190	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AY601_RS00195	COG0156	8-amino-7-oxononanoate synthase activity
AY601_RS00205	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AY601_RS00210	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AY601_RS00220	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AY601_RS00245	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AY601_RS00255	COG4774	siderophore transport
AY601_RS00265	COG3275	phosphorelay sensor kinase activity
AY601_RS00290	COG0205	6-phosphofructokinase activity
AY601_RS00310	COG0439	Biotin carboxylase
AY601_RS00315	COG0307	riboflavin synthase, alpha
AY601_RS00345	COG3185	4-Hydroxyphenylpyruvate dioxygenase
AY601_RS00355	COG0179	Fumarylacetoacetate (FAA) hydrolase
AY601_RS00370	COG0300	oxidoreductase activity
AY601_RS00375	COG3186	Phenylalanine-4-hydroxylase
AY601_RS00390	COG0423	glycine-tRNA ligase activity
AY601_RS00395	COG1131	(ABC) transporter
AY601_RS00420	COG0592	DNA-directed DNA polymerase activity
AY601_RS00425	COG0586	Pfam SNARE associated Golgi protein
AY601_RS00435	COG0443	Heat shock 70 kDa protein
AY601_RS00445	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AY601_RS00455	COG0513	Belongs to the DEAD box helicase family
AY601_RS00495	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AY601_RS00500	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AY601_RS00520	COG0633	Ferredoxin
AY601_RS00540	COG0424	maF-like protein
AY601_RS00545	COG0248	Ppx GppA phosphatase
AY601_RS00550	COG1668	transmembrane transport
AY601_RS00555	COG4152	abc transporter atp-binding protein
AY601_RS00565	COG0484	heat shock protein binding
AY601_RS00570	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AY601_RS00575	COG2884	Cell division ATP-binding protein ftsE
AY601_RS00590	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AY601_RS00600	COG0791	NLP P60 protein
AY601_RS00610	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AY601_RS00610	COG0140	phosphoribosyl-ATP diphosphatase activity
AY601_RS00615	COG0107	imidazoleglycerol-phosphate synthase activity
AY601_RS00620	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AY601_RS00630	COG0131	Imidazoleglycerol-phosphate dehydratase
AY601_RS00630	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AY601_RS00635	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AY601_RS00640	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AY601_RS00645	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AY601_RS00650	COG2989	Protein conserved in bacteria
AY601_RS00660	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AY601_RS00675	COG0463	Glycosyl transferase, family 2
AY601_RS00680	COG1216	Glycosyl transferase, family 2
AY601_RS00680	COG0463	Glycosyl transferase, family 2
AY601_RS00695	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AY601_RS00705	COG0484	heat shock protein binding
AY601_RS00710	COG2814	Major facilitator Superfamily
AY601_RS00725	COG0346	lactoylglutathione lyase activity
AY601_RS00730	COG0667	Aldo Keto reductase
AY601_RS00740	COG0488	(ABC) transporter
AY601_RS00750	COG0384	phenazine biosynthesis protein PhzF
AY601_RS00765	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AY601_RS00800	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
AY601_RS00805	COG1247	-acetyltransferase
AY601_RS00810	COG2132	Multicopper oxidase
AY601_RS00840	COG3321	synthase
AY601_RS00840	COG0604	alcohol dehydrogenase
AY601_RS00845	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AY601_RS00845	COG1028	Short-chain dehydrogenase reductase Sdr
AY601_RS00845	COG3321	synthase
AY601_RS00845	COG4221	oxidoreductase activity
AY601_RS00850	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AY601_RS00855	COG2267	carboxylic ester hydrolase activity
AY601_RS00885	COG4335	DNA alkylation repair
AY601_RS00895	COG0667	Aldo Keto reductase
AY601_RS00905	COG2249	NAD(P)H dehydrogenase (quinone) activity
AY601_RS00935	COG2169	Transcriptional regulator
AY601_RS00940	COG0584	glycerophosphoryl diester phosphodiesterase
AY601_RS00945	COG1316	TRANSCRIPTIONal
AY601_RS00950	COG0745	RESPONSE REGULATOR receiver
AY601_RS00965	COG0489	protein tyrosine kinase activity
AY601_RS00985	COG0110	maltose O-acetyltransferase activity
AY601_RS00990	COG0463	Glycosyl transferase, family 2
AY601_RS01000	COG1442	glycosyl transferase family 8
AY601_RS01010	COG2244	polysaccharide biosynthetic process
AY601_RS01025	COG1442	glycosyl transferase family 8
AY601_RS01070	COG0463	Glycosyl transferase, family 2
AY601_RS01075	COG1215	transferase activity, transferring glycosyl groups
AY601_RS01095	COG1309	transcriptional regulator
AY601_RS01105	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AY601_RS01130	COG0297	glycogen (starch) synthase activity
AY601_RS01135	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AY601_RS01140	COG1017	nitric oxide dioxygenase activity
AY601_RS01140	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AY601_RS01160	COG1136	(ABC) transporter
AY601_RS01165	COG0577	efflux transmembrane transporter activity
AY601_RS01170	COG1136	(ABC) transporter
AY601_RS01170	COG0577	efflux transmembrane transporter activity
AY601_RS01175	COG0577	efflux transmembrane transporter activity
AY601_RS01180	COG0577	efflux transmembrane transporter activity
AY601_RS01180	COG1136	(ABC) transporter
AY601_RS01185	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AY601_RS01195	COG3177	Filamentation induced by cAMP protein fic
AY601_RS01200	COG0544	peptidyl-prolyl cis-trans isomerase activity
AY601_RS01210	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AY601_RS01215	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AY601_RS01220	COG0588	phosphoglycerate mutase activity
AY601_RS01235	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AY601_RS01240	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AY601_RS01240	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AY601_RS01245	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AY601_RS01245	COG1796	DNA polymerase
AY601_RS01265	COG0616	signal peptide processing
AY601_RS01270	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AY601_RS01270	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AY601_RS01280	COG1183	phosphatidylcholine synthase activity
AY601_RS01290	COG0284	orotidine-5'-phosphate decarboxylase activity
AY601_RS01300	COG1674	ftsk spoiiie
AY601_RS01310	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AY601_RS01310	COG0321	lipoyl(octanoyl) transferase activity
AY601_RS01355	COG4771	TonB-dependent receptor
AY601_RS01425	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AY601_RS01430	COG0667	Aldo Keto reductase
AY601_RS01445	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AY601_RS01450	COG3239	Fatty acid desaturase
AY601_RS01465	COG0300	oxidoreductase activity
AY601_RS01525	COG2137	regulation of response to DNA damage stimulus
AY601_RS01530	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AY601_RS01540	COG1611	Belongs to the LOG family
AY601_RS01545	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AY601_RS01560	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AY601_RS01565	COG4221	oxidoreductase activity
AY601_RS01570	COG2272	Belongs to the type-B carboxylesterase lipase family
AY601_RS01595	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AY601_RS01600	COG0135	phosphoribosylanthranilate isomerase activity
AY601_RS01605	COG0133	tryptophan synthase activity
AY601_RS01610	COG0159	tryptophan synthase activity
AY601_RS01615	COG0009	L-threonylcarbamoyladenylate synthase
AY601_RS01620	COG0069	glutamate synthase activity
AY601_RS01625	COG3590	peptidase
AY601_RS01630	COG0017	Asparaginyl-tRNA synthetase
AY601_RS01635	COG0045	succinate-CoA ligase (ADP-forming) activity
AY601_RS01640	COG1136	(ABC) transporter
AY601_RS01660	COG2234	aminopeptidase activity
AY601_RS01665	COG0667	Aldo Keto reductase
AY601_RS01675	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AY601_RS01680	COG3655	Transcriptional regulator
AY601_RS01685	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AY601_RS01690	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AY601_RS01700	COG1309	transcriptional regulator
AY601_RS01740	COG4771	TonB-dependent receptor
AY601_RS01745	COG2207	Transcriptional regulator
AY601_RS01750	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AY601_RS01760	COG0346	lactoylglutathione lyase activity
AY601_RS01765	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AY601_RS01775	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AY601_RS01780	COG0328	RNA-DNA hybrid ribonuclease activity
AY601_RS01790	COG0163	prenyltransferase activity
AY601_RS01795	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AY601_RS01800	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AY601_RS01805	COG0483	inositol monophosphate 1-phosphatase activity
AY601_RS01810	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AY601_RS01830	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AY601_RS01840	COG0450	alkyl hydroperoxide reductase
AY601_RS01855	COG0527	aspartate kinase activity
AY601_RS01865	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AY601_RS01875	COG1193	negative regulation of DNA recombination
AY601_RS01880	COG2133	pyrroloquinoline quinone binding
AY601_RS01885	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AY601_RS01900	COG3942	CHAP domain
AY601_RS01900	COG1388	LysM domain
AY601_RS01905	COG0783	Belongs to the Dps family
AY601_RS01925	COG0442	prolyl-tRNA aminoacylation
AY601_RS01930	COG0626	cystathionine gamma-synthase activity
AY601_RS01945	COG0463	Glycosyl transferase, family 2
AY601_RS01950	COG3104	oligopeptide transport
AY601_RS01955	COG3104	oligopeptide transport
AY601_RS01965	COG0183	Belongs to the thiolase family
AY601_RS02005	COG2084	Dehydrogenase
AY601_RS02020	COG1725	Transcriptional regulator
AY601_RS02030	COG1522	sequence-specific DNA binding
AY601_RS02040	COG1629	transport
AY601_RS02060	COG0156	8-amino-7-oxononanoate synthase activity
AY601_RS02090	COG1619	proteins homologs of microcin C7 resistance protein MccF
AY601_RS02100	COG4771	TonB-dependent receptor
AY601_RS02115	COG0577	efflux transmembrane transporter activity
AY601_RS02115	COG1136	(ABC) transporter
AY601_RS02135	COG1733	regulation of RNA biosynthetic process
AY601_RS02150	COG0251	oxidation-reduction process
AY601_RS02155	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
AY601_RS02155	COG0028	Belongs to the TPP enzyme family
AY601_RS02160	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AY601_RS02165	COG0436	Aminotransferase
AY601_RS02195	COG3475	LICD family
AY601_RS02205	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AY601_RS02210	COG2813	Specifically methylates the guanine in position
AY601_RS02295	COG4974	Belongs to the 'phage' integrase family
AY601_RS02320	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AY601_RS02325	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
AY601_RS02330	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
AY601_RS02345	COG2205	protein histidine kinase activity
AY601_RS02350	COG5002	protein histidine kinase activity
AY601_RS02360	COG1228	amidohydrolase
AY601_RS02365	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AY601_RS02380	COG1368	sulfuric ester hydrolase activity
AY601_RS02385	COG0671	phosphoesterase, PA-phosphatase related
AY601_RS02400	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AY601_RS02415	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AY601_RS02425	COG0025	NhaP-type Na H and K H
AY601_RS02480	COG0542	response to heat
AY601_RS02540	COG4206	TonB-dependent receptor
AY601_RS02540	COG1629	transport
AY601_RS02635	COG1480	7TM receptor with intracellular HD hydrolase
AY601_RS02640	COG2204	response regulator
AY601_RS02650	COG0475	glutathione-regulated potassium exporter activity
AY601_RS02650	COG0589	response to stress
AY601_RS02660	COG0667	Aldo Keto reductase
AY601_RS02685	COG3158	transport of potassium into the cell
AY601_RS02720	COG1301	dicarboxylic acid transport
AY601_RS02730	COG0492	ferredoxin-NADP+ reductase activity
AY601_RS02735	COG1309	transcriptional regulator
AY601_RS02740	COG0784	Response regulator, receiver
AY601_RS02740	COG5002	protein histidine kinase activity
AY601_RS02745	COG0583	DNA-binding transcription factor activity
AY601_RS02750	COG2855	membrane
AY601_RS02760	COG0443	Heat shock 70 kDa protein
AY601_RS02815	COG4771	TonB-dependent receptor
AY601_RS02830	COG0584	glycerophosphoryl diester phosphodiesterase
AY601_RS02840	COG0745	RESPONSE REGULATOR receiver
AY601_RS02840	COG2205	protein histidine kinase activity
AY601_RS02840	COG3292	Two component regulator propeller
AY601_RS02845	COG2814	Major facilitator Superfamily
AY601_RS02850	COG1629	transport
AY601_RS02850	COG4206	TonB-dependent receptor
AY601_RS02860	COG1621	beta-fructofuranosidase activity
AY601_RS02865	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AY601_RS02870	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AY601_RS02880	COG1629	transport
AY601_RS02880	COG4206	TonB-dependent receptor
AY601_RS02895	COG2205	protein histidine kinase activity
AY601_RS02895	COG0784	Response regulator, receiver
AY601_RS02940	COG4191	Histidine kinase
AY601_RS02945	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AY601_RS02950	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
AY601_RS02980	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AY601_RS02985	COG3850	Histidine kinase
AY601_RS02985	COG5002	protein histidine kinase activity
AY601_RS02990	COG0745	RESPONSE REGULATOR receiver
AY601_RS03000	COG2160	L-arabinose isomerase activity
AY601_RS03015	COG1069	ribulokinase activity
AY601_RS03025	COG2205	protein histidine kinase activity
AY601_RS03025	COG3292	Two component regulator propeller
AY601_RS03025	COG0745	RESPONSE REGULATOR receiver
AY601_RS03025	COG2205	protein histidine kinase activity
AY601_RS03025	COG3292	Two component regulator propeller
AY601_RS03025	COG0745	RESPONSE REGULATOR receiver
AY601_RS03030	COG4771	TonB-dependent receptor
AY601_RS03060	COG4771	TonB-dependent receptor
AY601_RS03065	COG0702	epimerase
AY601_RS03080	COG3507	Belongs to the glycosyl hydrolase 43 family
AY601_RS03125	COG0700	Nucleoside recognition
AY601_RS03135	COG0706	membrane insertase activity
AY601_RS03140	COG0504	CTP synthase activity
AY601_RS03150	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AY601_RS03155	COG1428	Deoxynucleoside kinase
AY601_RS03160	COG0180	Tryptophanyl-tRNA synthetase
AY601_RS03165	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AY601_RS03170	COG1136	(ABC) transporter
AY601_RS03190	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AY601_RS03195	COG1136	(ABC) transporter
AY601_RS03195	COG0577	efflux transmembrane transporter activity
AY601_RS03215	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AY601_RS03235	COG1793	dna ligase
AY601_RS03245	COG1028	Short-chain dehydrogenase reductase Sdr
AY601_RS03265	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AY601_RS03280	COG0658	competence protein
AY601_RS03295	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AY601_RS03305	COG2217	Heavy metal translocating P-type atpase
AY601_RS03320	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AY601_RS03325	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AY601_RS03330	COG0745	RESPONSE REGULATOR receiver
AY601_RS03335	COG0564	pseudouridine synthase activity
AY601_RS03350	COG5002	protein histidine kinase activity
AY601_RS03370	COG5006	permease, DMT superfamily
AY601_RS03375	COG0501	Belongs to the peptidase M48B family
AY601_RS03385	COG2223	nitrite transmembrane transporter activity
AY601_RS03395	COG1309	transcriptional regulator
AY601_RS03420	COG0300	oxidoreductase activity
AY601_RS03425	COG1595	DNA-templated transcription, initiation
AY601_RS03435	COG4206	TonB-dependent receptor
AY601_RS03435	COG1629	transport
AY601_RS03445	COG1446	asparaginase
AY601_RS03450	COG4242	Belongs to the peptidase S51 family
AY601_RS03465	COG1733	regulation of RNA biosynthetic process
AY601_RS03485	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AY601_RS03495	COG1396	sequence-specific DNA binding
AY601_RS03500	COG3550	peptidyl-serine autophosphorylation
AY601_RS03505	COG3550	peptidyl-serine autophosphorylation
AY601_RS03535	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AY601_RS03545	COG0668	transmembrane transport
AY601_RS03550	COG1064	alcohol dehydrogenase
AY601_RS03560	COG2011	ABC-type metal ion transport system permease component
AY601_RS03565	COG1464	Belongs to the NlpA lipoprotein family
AY601_RS03595	COG0772	Belongs to the SEDS family
AY601_RS03625	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AY601_RS03635	COG1595	DNA-templated transcription, initiation
AY601_RS03685	COG3292	Two component regulator propeller
AY601_RS03685	COG2205	protein histidine kinase activity
AY601_RS03685	COG0745	RESPONSE REGULATOR receiver
AY601_RS03690	COG4771	TonB-dependent receptor
AY601_RS03695	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
AY601_RS03710	COG4585	Histidine kinase
AY601_RS03745	COG0719	Fe-S assembly protein
AY601_RS03750	COG0396	ATPase activity
AY601_RS03755	COG0719	Fe-S assembly protein
AY601_RS03760	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AY601_RS03765	COG2166	iron-sulfur cluster assembly
AY601_RS03770	COG2151	metal-sulfur cluster biosynthetic enzyme
AY601_RS03785	COG3279	Response regulator of the LytR AlgR family
AY601_RS03790	COG3275	phosphorelay sensor kinase activity
AY601_RS03800	COG2207	Transcriptional regulator
AY601_RS03800	COG0662	Cupin 2, conserved barrel domain protein
AY601_RS03805	COG3254	rhamnose metabolic process
AY601_RS03810	COG2721	sulfolactate sulfo-lyase activity
AY601_RS03815	COG1028	Short-chain dehydrogenase reductase Sdr
AY601_RS03820	COG0179	Fumarylacetoacetate (FAA) hydrolase
AY601_RS03825	COG1028	Short-chain dehydrogenase reductase Sdr
AY601_RS03850	COG1260	myo-inositol-1-phosphate synthase
AY601_RS03875	COG1492	cobalamin metabolic process
AY601_RS03880	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AY601_RS03890	COG1660	Displays ATPase and GTPase activities
AY601_RS03900	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AY601_RS03905	COG1120	ATPase activity
AY601_RS03910	COG4771	TonB-dependent receptor
AY601_RS03920	COG2096	Adenosyltransferase
AY601_RS03930	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AY601_RS03935	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AY601_RS04065	COG1570	exodeoxyribonuclease VII activity
AY601_RS04080	COG0745	RESPONSE REGULATOR receiver
AY601_RS04090	COG0667	Aldo Keto reductase
AY601_RS04095	COG1607	acyl-coa hydrolase
AY601_RS04100	COG0673	inositol 2-dehydrogenase activity
AY601_RS04110	COG0523	cobalamin synthesis protein
AY601_RS04145	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AY601_RS04190	COG0577	efflux transmembrane transporter activity
AY601_RS04195	COG2378	regulation of single-species biofilm formation
AY601_RS04240	COG1629	transport
AY601_RS04265	COG0545	Peptidyl-prolyl cis-trans isomerase
AY601_RS04325	COG0463	Glycosyl transferase, family 2
AY601_RS04375	COG1278	Cold shock
AY601_RS04385	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AY601_RS04390	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AY601_RS04395	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AY601_RS04400	COG0156	8-amino-7-oxononanoate synthase activity
AY601_RS04410	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AY601_RS04415	COG3264	Mechanosensitive ion channel
AY601_RS04415	COG1511	domain protein
AY601_RS04425	COG0432	Pfam Uncharacterised protein family UPF0047
AY601_RS04440	COG0076	glutamate decarboxylase activity
AY601_RS04450	COG3486	L-lysine 6-monooxygenase (NADPH) activity
AY601_RS04460	COG3844	kynureninase activity
AY601_RS04465	COG3781	membrane
AY601_RS04470	COG0123	including yeast histone deacetylase and acetoin utilization protein
AY601_RS04500	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AY601_RS04515	COG1309	transcriptional regulator
AY601_RS04525	COG2814	Major facilitator Superfamily
AY601_RS04535	COG1695	Transcriptional regulator
AY601_RS04550	COG1312	Catalyzes the dehydration of D-mannonate
AY601_RS04555	COG1904	glucuronate isomerase
AY601_RS04560	COG2271	Major facilitator Superfamily
AY601_RS04585	COG3279	Response regulator of the LytR AlgR family
AY601_RS04765	COG0577	efflux transmembrane transporter activity
AY601_RS04815	COG0351	phosphomethylpyrimidine kinase
AY601_RS04820	COG5002	protein histidine kinase activity
AY601_RS04835	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AY601_RS04860	COG2824	Alkylphosphonate utilization operon protein PhnA
AY601_RS04870	COG1752	Esterase of the alpha-beta hydrolase superfamily
AY601_RS04920	COG2207	Transcriptional regulator
AY601_RS04920	COG1917	Cupin 2, conserved barrel domain protein
AY601_RS04935	COG1070	Carbohydrate kinase
AY601_RS04945	COG1028	Short-chain dehydrogenase reductase Sdr
AY601_RS04955	COG0513	Belongs to the DEAD box helicase family
AY601_RS04970	COG1309	transcriptional regulator
AY601_RS04975	COG1028	Short-chain dehydrogenase reductase Sdr
AY601_RS05000	COG2814	Major facilitator Superfamily
AY601_RS05020	COG0577	efflux transmembrane transporter activity
AY601_RS05045	COG0667	Aldo Keto reductase
AY601_RS05065	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AY601_RS05090	COG0460	homoserine dehydrogenase
AY601_RS05100	COG4615	Cyclic peptide transporter
AY601_RS05135	COG1629	transport
AY601_RS05135	COG4206	TonB-dependent receptor
AY601_RS05140	COG0745	RESPONSE REGULATOR receiver
AY601_RS05150	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AY601_RS05155	COG2808	Putative FMN-binding domain
AY601_RS05170	COG1595	DNA-templated transcription, initiation
AY601_RS05180	COG1285	pathogenesis
AY601_RS05210	COG0583	DNA-binding transcription factor activity
AY601_RS05260	COG0667	Aldo Keto reductase
AY601_RS05280	COG3940	Belongs to the glycosyl hydrolase 43 family
AY601_RS05355	COG3279	Response regulator of the LytR AlgR family
AY601_RS05400	COG1012	belongs to the aldehyde dehydrogenase family
AY601_RS05405	COG0038	chloride channel
AY601_RS05420	COG1573	uracil-dna glycosylase
AY601_RS05425	COG1902	pentaerythritol trinitrate reductase activity
AY601_RS05435	COG1902	pentaerythritol trinitrate reductase activity
AY601_RS05450	COG0702	epimerase
AY601_RS05455	COG1917	Cupin 2, conserved barrel domain protein
AY601_RS05455	COG2207	Transcriptional regulator
AY601_RS05525	COG1595	DNA-templated transcription, initiation
AY601_RS05550	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AY601_RS05555	COG0516	GMP reductase activity
AY601_RS05555	COG0517	IMP dehydrogenase activity
AY601_RS05595	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AY601_RS05605	COG0693	protein deglycase activity
AY601_RS05625	COG4251	negative regulation of phosphorylation
AY601_RS05630	COG4251	negative regulation of phosphorylation
AY601_RS05660	COG3685	Protein conserved in bacteria
AY601_RS05665	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AY601_RS05700	COG0456	acetyltransferase
AY601_RS05705	COG5002	protein histidine kinase activity
AY601_RS05715	COG1917	Cupin 2, conserved barrel domain protein
AY601_RS05715	COG4977	sequence-specific DNA binding
AY601_RS05735	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AY601_RS05760	COG0251	oxidation-reduction process
AY601_RS05770	COG0412	Dienelactone hydrolase
AY601_RS05820	COG0577	efflux transmembrane transporter activity
AY601_RS05830	COG1131	(ABC) transporter
AY601_RS05835	COG1629	transport
AY601_RS05840	COG0702	epimerase
AY601_RS05850	COG3250	beta-galactosidase activity
AY601_RS05855	COG3250	beta-galactosidase activity
AY601_RS05865	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
AY601_RS05915	COG2197	response regulator
AY601_RS05930	COG2771	luxR family
AY601_RS05955	COG5002	protein histidine kinase activity
AY601_RS06020	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
AY601_RS06055	COG2226	methyltransferase
AY601_RS06115	COG1522	sequence-specific DNA binding
AY601_RS06120	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AY601_RS06120	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AY601_RS06125	COG1104	cysteine desulfurase activity
AY601_RS06165	COG4771	TonB-dependent receptor
AY601_RS06170	COG2207	Transcriptional regulator
AY601_RS06170	COG0662	Cupin 2, conserved barrel domain protein
AY601_RS06180	COG0129	dihydroxy-acid dehydratase activity
AY601_RS06185	COG2130	NADP-dependent
AY601_RS06215	COG2272	Belongs to the type-B carboxylesterase lipase family
AY601_RS06220	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AY601_RS06225	COG0596	Alpha beta hydrolase
AY601_RS06265	COG1309	transcriptional regulator
AY601_RS06290	COG5002	protein histidine kinase activity
AY601_RS06295	COG3279	Response regulator of the LytR AlgR family
AY601_RS06300	COG3275	phosphorelay sensor kinase activity
AY601_RS06320	COG0798	PFAM Bile acid sodium symporter
AY601_RS06325	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AY601_RS06340	COG0076	glutamate decarboxylase activity
AY601_RS06345	COG0671	phosphoesterase, PA-phosphatase related
AY601_RS06350	COG0456	acetyltransferase
AY601_RS06390	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AY601_RS06400	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AY601_RS06420	COG0305	Participates in initiation and elongation during chromosome replication
AY601_RS06425	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AY601_RS06435	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AY601_RS06435	COG0517	IMP dehydrogenase activity
AY601_RS06440	COG0514	ATP-dependent DNA helicase (RecQ)
AY601_RS06445	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AY601_RS06455	COG0602	queuosine metabolic process
AY601_RS06465	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AY601_RS06470	COG0481	GTPase activity
AY601_RS06475	COG3142	Participates in the control of copper homeostasis
AY601_RS06480	COG1446	asparaginase
AY601_RS06490	COG0436	Aminotransferase
AY601_RS06495	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AY601_RS06505	COG0724	RNA recognition motif
AY601_RS06515	COG4953	penicillin-binding protein 1C
AY601_RS06520	COG2373	Large extracellular alpha-helical protein
AY601_RS06530	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AY601_RS06530	COG1754	DNA topoisomerase type I activity
AY601_RS06535	COG0386	Belongs to the glutathione peroxidase family
AY601_RS06545	COG0737	Belongs to the 5'-nucleotidase family
AY601_RS06550	COG0482	sulfurtransferase activity
AY601_RS06555	COG3537	Alpha-1,2-mannosidase
AY601_RS06575	COG4974	Belongs to the 'phage' integrase family
AY601_RS06590	COG2267	carboxylic ester hydrolase activity
AY601_RS06615	COG2433	Pfam Transposase IS66
AY601_RS06635	COG0657	acetylesterase activity
AY601_RS06640	COG2249	NAD(P)H dehydrogenase (quinone) activity
AY601_RS06650	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AY601_RS06685	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AY601_RS06700	COG2814	Major facilitator Superfamily
AY601_RS06705	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AY601_RS06705	COG0392	lysyltransferase activity
AY601_RS06715	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AY601_RS06720	COG1252	NADH dehydrogenase
AY601_RS06730	COG0745	RESPONSE REGULATOR receiver
AY601_RS06735	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AY601_RS06770	COG1858	cytochrome C peroxidase
AY601_RS06790	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AY601_RS06840	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AY601_RS06845	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AY601_RS06855	COG0067	glutamate synthase
AY601_RS06855	COG0070	glutamate synthase
AY601_RS06855	COG0069	glutamate synthase activity
AY601_RS06870	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AY601_RS06900	COG4206	TonB-dependent receptor
AY601_RS06905	COG1741	Belongs to the pirin family
AY601_RS06935	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AY601_RS06940	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AY601_RS06945	COG0579	oxidoreductase
AY601_RS06955	COG1522	sequence-specific DNA binding
AY601_RS06975	COG0668	transmembrane transport
AY601_RS06980	COG2814	Major facilitator Superfamily
AY601_RS06985	COG0813	purine-nucleoside phosphorylase activity
AY601_RS06990	COG1739	Uncharacterized protein family UPF0029
AY601_RS06995	COG0697	spore germination
AY601_RS07000	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AY601_RS07000	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AY601_RS07005	COG2890	protein-(glutamine-N5) methyltransferase activity
AY601_RS07010	COG4974	Belongs to the 'phage' integrase family
AY601_RS07015	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AY601_RS07020	COG1215	transferase activity, transferring glycosyl groups
AY601_RS07030	COG0598	Magnesium transport protein CorA
AY601_RS07035	COG2239	Acts as a magnesium transporter
AY601_RS07050	COG1764	response to oxidative stress
AY601_RS07055	COG1289	transmembrane transporter activity
AY601_RS07070	COG1012	belongs to the aldehyde dehydrogenase family
AY601_RS07075	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AY601_RS07090	COG0531	amino acid
AY601_RS07095	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AY601_RS07100	COG1063	alcohol dehydrogenase
AY601_RS07115	COG4771	TonB-dependent receptor
AY601_RS07150	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AY601_RS07155	COG0408	coproporphyrinogen oxidase activity
AY601_RS07175	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
AY601_RS07190	COG0534	Mate efflux family protein
AY601_RS07220	COG4251	negative regulation of phosphorylation
AY601_RS07230	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AY601_RS07250	COG1733	regulation of RNA biosynthetic process
AY601_RS07275	COG2205	protein histidine kinase activity
AY601_RS07365	COG0861	Integral membrane protein TerC family
AY601_RS07370	COG3622	Belongs to the hyi family
AY601_RS07375	COG1477	protein flavinylation
AY601_RS07380	COG0673	inositol 2-dehydrogenase activity
AY601_RS07385	COG0515	serine threonine protein kinase
AY601_RS07385	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AY601_RS07395	COG1629	transport
AY601_RS07405	COG1191	sigma factor activity
AY601_RS07415	COG0477	Major facilitator Superfamily
AY601_RS07420	COG1733	regulation of RNA biosynthetic process
AY601_RS07435	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AY601_RS07465	COG2855	membrane
AY601_RS07485	COG2197	response regulator
AY601_RS07555	COG0583	DNA-binding transcription factor activity
AY601_RS07570	COG1012	belongs to the aldehyde dehydrogenase family
AY601_RS07575	COG0277	FAD linked oxidase domain protein
AY601_RS07575	COG0247	lactate metabolic process
AY601_RS07580	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AY601_RS07585	COG1127	ABC transporter
AY601_RS07595	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AY601_RS07615	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
AY601_RS07635	COG2318	DinB family
AY601_RS07655	COG5002	protein histidine kinase activity
AY601_RS07670	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AY601_RS07700	COG1640	4-alpha-glucanotransferase
AY601_RS07725	COG3279	Response regulator of the LytR AlgR family
AY601_RS07735	COG0596	Alpha beta hydrolase
AY601_RS07740	COG1028	Short-chain dehydrogenase reductase Sdr
AY601_RS07750	COG5002	protein histidine kinase activity
AY601_RS07755	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
AY601_RS07795	COG1858	cytochrome C peroxidase
AY601_RS07835	COG0702	epimerase
AY601_RS07840	COG4771	TonB-dependent receptor
AY601_RS07845	COG1012	belongs to the aldehyde dehydrogenase family
AY601_RS07850	COG1904	glucuronate isomerase
AY601_RS07855	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
AY601_RS07865	COG1609	Transcriptional regulator
AY601_RS07870	COG2721	sulfolactate sulfo-lyase activity
AY601_RS07880	COG0477	Major facilitator Superfamily
AY601_RS07890	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AY601_RS07905	COG5002	protein histidine kinase activity
AY601_RS07915	COG0861	Integral membrane protein TerC family
AY601_RS07920	COG2885	chlorophyll binding
AY601_RS07925	COG2310	stress, protein
AY601_RS07980	COG1280	lysine exporter protein (LysE YggA)
AY601_RS07985	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
AY601_RS07985	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
AY601_RS07990	COG2315	Protein conserved in bacteria
AY601_RS08015	COG1131	(ABC) transporter
AY601_RS08035	COG0628	permease
AY601_RS08065	COG0671	phosphoesterase, PA-phosphatase related
AY601_RS08070	COG0789	Transcriptional regulator
AY601_RS08090	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
AY601_RS08130	COG2186	Transcriptional regulator
AY601_RS08140	COG1917	Cupin 2, conserved barrel domain protein
AY601_RS08150	COG2271	Major facilitator Superfamily
AY601_RS08160	COG1629	transport
AY601_RS08165	COG0561	phosphatase activity
AY601_RS08185	COG0800	Aldolase
AY601_RS08195	COG1012	belongs to the aldehyde dehydrogenase family
AY601_RS08240	COG2249	NAD(P)H dehydrogenase (quinone) activity
AY601_RS08255	COG0667	Aldo Keto reductase
AY601_RS08270	COG0494	nUDIX hydrolase
AY601_RS08280	COG0500	methyltransferase
AY601_RS08285	COG1956	GAF domain-containing protein
AY601_RS08295	COG2205	protein histidine kinase activity
AY601_RS08300	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AY601_RS08305	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AY601_RS08310	COG1780	Probably involved in ribonucleotide reductase function
AY601_RS08325	COG0247	lactate metabolic process
AY601_RS08335	COG0514	ATP-dependent DNA helicase (RecQ)
AY601_RS08340	COG2081	HI0933 family
AY601_RS08345	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AY601_RS08350	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AY601_RS08355	COG1678	Uncharacterized ACR, COG1678
AY601_RS08360	COG0259	pyridoxamine-phosphate oxidase activity
AY601_RS08365	COG1250	3-hydroxyacyl-CoA dehydrogenase
AY601_RS08370	COG2255	four-way junction helicase activity
AY601_RS08375	COG3153	acetyltransferase
AY601_RS08375	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AY601_RS08390	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AY601_RS08405	COG0791	NLP P60 protein
AY601_RS08410	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AY601_RS08425	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AY601_RS08435	COG0626	cystathionine gamma-synthase activity
AY601_RS08440	COG2873	o-acetylhomoserine
AY601_RS08445	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AY601_RS08450	COG0460	homoserine dehydrogenase
AY601_RS08465	COG1078	dGTPase activity
AY601_RS08470	COG0508	dehydrogenase complex catalyzes the overall conversion of
AY601_RS08485	COG0860	N-Acetylmuramoyl-L-alanine amidase
AY601_RS08495	COG1028	Short-chain dehydrogenase reductase Sdr
AY601_RS08520	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AY601_RS08525	COG1702	phosphate starvation-inducible protein PhoH
AY601_RS08545	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AY601_RS08550	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AY601_RS08555	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AY601_RS08560	COG0577	efflux transmembrane transporter activity
AY601_RS08565	COG1185	polyribonucleotide nucleotidyltransferase activity
AY601_RS08570	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AY601_RS08575	COG0824	Thioesterase
AY601_RS08590	COG2274	protein secretion by the type I secretion system
AY601_RS08605	COG1181	Belongs to the D-alanine--D-alanine ligase family
AY601_RS08625	COG1295	ribonuclease BN
AY601_RS08645	COG4974	Belongs to the 'phage' integrase family
AY601_RS08725	COG1074	ATP-dependent DNA helicase activity
AY601_RS08730	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AY601_RS08890	COG1733	regulation of RNA biosynthetic process
AY601_RS08895	COG1028	Short-chain dehydrogenase reductase Sdr
AY601_RS08900	COG3328	transposase activity
AY601_RS08920	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AY601_RS08925	COG2072	flavoprotein involved in K transport
AY601_RS08935	COG0436	Aminotransferase
AY601_RS08960	COG4977	sequence-specific DNA binding
AY601_RS08960	COG1917	Cupin 2, conserved barrel domain protein
AY601_RS08965	COG4221	oxidoreductase activity
AY601_RS08970	COG0667	Aldo Keto reductase
AY601_RS08975	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AY601_RS08975	COG2755	lipolytic protein G-D-S-L family
AY601_RS08980	COG2382	esterase
AY601_RS08980	COG3507	Belongs to the glycosyl hydrolase 43 family
AY601_RS08980	COG3693	PFAM glycoside hydrolase, family 10
AY601_RS09000	COG2267	carboxylic ester hydrolase activity
AY601_RS09045	COG0784	Response regulator, receiver
AY601_RS09045	COG2205	protein histidine kinase activity
AY601_RS09045	COG5002	protein histidine kinase activity
AY601_RS09050	COG1917	Cupin 2, conserved barrel domain protein
AY601_RS09050	COG4977	sequence-specific DNA binding
AY601_RS09080	COG0644	oxidoreductase
AY601_RS09105	COG1295	ribonuclease BN
AY601_RS09105	COG1959	2 iron, 2 sulfur cluster binding
AY601_RS09140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AY601_RS09155	COG5001	Diguanylate cyclase
AY601_RS09155	COG5002	protein histidine kinase activity
AY601_RS09155	COG3447	MASE1 domain protein
AY601_RS09195	COG1028	Short-chain dehydrogenase reductase Sdr
AY601_RS09200	COG1028	Short-chain dehydrogenase reductase Sdr
AY601_RS09230	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
AY601_RS09235	COG4977	sequence-specific DNA binding
AY601_RS09235	COG1917	Cupin 2, conserved barrel domain protein
AY601_RS09245	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AY601_RS09255	COG4221	oxidoreductase activity
AY601_RS09260	COG4977	sequence-specific DNA binding
AY601_RS09260	COG1917	Cupin 2, conserved barrel domain protein
AY601_RS09270	COG3047	cAMP biosynthetic process
AY601_RS09320	COG2382	esterase
AY601_RS09325	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AY601_RS09330	COG4771	TonB-dependent receptor
AY601_RS09340	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AY601_RS09350	COG1607	acyl-coa hydrolase
AY601_RS09360	COG0604	alcohol dehydrogenase
AY601_RS09375	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AY601_RS09420	COG1629	transport
AY601_RS09420	COG4206	TonB-dependent receptor
AY601_RS09425	COG1940	carbohydrate kinase activity
AY601_RS09425	COG1846	Transcriptional regulator
AY601_RS09440	COG0366	Alpha amylase catalytic
AY601_RS09455	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AY601_RS09460	COG1522	sequence-specific DNA binding
AY601_RS09465	COG0697	spore germination
AY601_RS09475	COG0860	N-Acetylmuramoyl-L-alanine amidase
AY601_RS09505	COG0784	Response regulator, receiver
AY601_RS09505	COG2198	Histidine kinase
AY601_RS09505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AY601_RS09505	COG2205	protein histidine kinase activity
AY601_RS09555	COG1090	epimerase
AY601_RS09605	COG2814	Major facilitator Superfamily
AY601_RS09640	COG2113	Glycine betaine
AY601_RS09645	COG4176	ABC-type proline glycine betaine transport system permease component
AY601_RS09665	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AY601_RS09665	COG0047	phosphoribosylformylglycinamidine synthase activity
AY601_RS09670	COG2226	methyltransferase
AY601_RS09715	COG2972	Histidine kinase
AY601_RS09720	COG2972	Histidine kinase
AY601_RS09750	COG1131	(ABC) transporter
AY601_RS09760	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AY601_RS09765	COG1902	pentaerythritol trinitrate reductase activity
AY601_RS09770	COG1733	regulation of RNA biosynthetic process
AY601_RS09775	COG2989	Protein conserved in bacteria
AY601_RS09780	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AY601_RS09795	COG2353	YceI-like domain
AY601_RS09820	COG0702	epimerase
AY601_RS09825	COG4771	TonB-dependent receptor
AY601_RS09855	COG2273	Hydrolase Family 16
AY601_RS09895	COG0270	DNA (cytosine-5-)-methyltransferase activity
AY601_RS09980	COG2433	Pfam Transposase IS66
AY601_RS10035	COG0702	epimerase
AY601_RS10040	COG4771	TonB-dependent receptor
AY601_RS10045	COG3940	Belongs to the glycosyl hydrolase 43 family
AY601_RS10105	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AY601_RS10210	COG1629	transport
AY601_RS10240	COG0484	heat shock protein binding
AY601_RS10265	COG2433	Pfam Transposase IS66
AY601_RS10305	COG3408	Glycogen debranching enzyme
AY601_RS10310	COG0702	epimerase
AY601_RS10315	COG4771	TonB-dependent receptor
AY601_RS10320	COG3250	beta-galactosidase activity
AY601_RS10330	COG4952	isomerase
AY601_RS10335	COG3347	Dehydrogenase
AY601_RS10335	COG1028	Short-chain dehydrogenase reductase Sdr
AY601_RS10365	COG4251	negative regulation of phosphorylation
AY601_RS10395	COG1132	(ABC) transporter
AY601_RS10400	COG2423	ornithine cyclodeaminase activity
AY601_RS10405	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AY601_RS10430	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AY601_RS10505	COG0662	Cupin 2, conserved barrel domain protein
AY601_RS10505	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
AY601_RS10545	COG0546	phosphoglycolate phosphatase activity
AY601_RS10550	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AY601_RS10585	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AY601_RS10620	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AY601_RS10655	COG1629	transport
AY601_RS10695	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AY601_RS10700	COG0730	response to heat
AY601_RS10715	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AY601_RS10785	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AY601_RS10790	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AY601_RS10790	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AY601_RS10805	COG0527	aspartate kinase activity
AY601_RS10820	COG2755	lipolytic protein G-D-S-L family
AY601_RS10840	COG1733	regulation of RNA biosynthetic process
AY601_RS10870	COG4771	TonB-dependent receptor
AY601_RS10875	COG2205	protein histidine kinase activity
AY601_RS10875	COG0745	RESPONSE REGULATOR receiver
AY601_RS10875	COG3292	Two component regulator propeller
AY601_RS10920	COG0277	FAD linked oxidase domain protein
AY601_RS10925	COG3185	4-Hydroxyphenylpyruvate dioxygenase
AY601_RS10950	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AY601_RS10995	COG1132	(ABC) transporter
AY601_RS11010	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AY601_RS11035	COG1674	ftsk spoiiie
AY601_RS11040	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AY601_RS11065	COG4804	nuclease activity
AY601_RS11070	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AY601_RS11075	COG0628	permease
AY601_RS11085	COG0018	arginyl-trna synthetase
AY601_RS11090	COG0010	Belongs to the arginase family
AY601_RS11095	COG1166	arginine decarboxylase activity
AY601_RS11105	COG0824	Thioesterase
AY601_RS11110	COG0277	FAD linked oxidase domain protein
AY601_RS11120	COG1960	acyl-CoA dehydrogenase activity
AY601_RS11135	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AY601_RS11185	COG0019	diaminopimelate decarboxylase activity
AY601_RS11190	COG0527	aspartate kinase activity
AY601_RS11195	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AY601_RS11205	COG0484	heat shock protein binding
AY601_RS11215	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AY601_RS11220	COG0028	Belongs to the TPP enzyme family
AY601_RS11225	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AY601_RS11235	COG1999	signal sequence binding
AY601_RS11250	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AY601_RS11255	COG1999	signal sequence binding
AY601_RS11290	COG2814	Major facilitator Superfamily
AY601_RS11315	COG0745	RESPONSE REGULATOR receiver
AY601_RS11325	COG4181	ATPase activity
AY601_RS11370	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AY601_RS11375	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AY601_RS11390	COG1902	pentaerythritol trinitrate reductase activity
AY601_RS11395	COG0640	Transcriptional regulator
AY601_RS11405	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AY601_RS11415	COG0517	IMP dehydrogenase activity
AY601_RS11415	COG1125	glycine betaine transport
AY601_RS11420	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AY601_RS11425	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AY601_RS11430	COG0427	acetyl-CoA hydrolase
AY601_RS11445	COG2217	Heavy metal translocating P-type atpase
AY601_RS11495	COG2326	polyphosphate kinase activity
AY601_RS11500	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AY601_RS11525	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AY601_RS11530	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AY601_RS11535	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AY601_RS11540	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AY601_RS11545	COG0583	DNA-binding transcription factor activity
AY601_RS11550	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AY601_RS11555	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AY601_RS11560	COG3720	iron ion transport
AY601_RS11565	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AY601_RS11570	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AY601_RS11575	COG4558	Periplasmic binding protein
AY601_RS11585	COG4771	TonB-dependent receptor
AY601_RS11590	COG3279	Response regulator of the LytR AlgR family
AY601_RS11600	COG2197	response regulator
AY601_RS11605	COG2201	protein-glutamate methylesterase activity
AY601_RS11625	COG2353	YceI-like domain
AY601_RS11630	COG3590	peptidase
AY601_RS11635	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AY601_RS11640	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AY601_RS11675	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AY601_RS11680	COG1073	alpha beta
AY601_RS11725	COG0745	RESPONSE REGULATOR receiver
AY601_RS11730	COG2205	protein histidine kinase activity
AY601_RS11765	COG0281	malic enzyme
AY601_RS11765	COG0280	phosphate acetyltransferase
AY601_RS11775	COG1045	serine acetyltransferase
AY601_RS11780	COG0668	transmembrane transport
AY601_RS11790	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
AY601_RS11810	COG1595	DNA-templated transcription, initiation
AY601_RS11815	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AY601_RS11820	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AY601_RS11825	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AY601_RS11835	COG1764	response to oxidative stress
AY601_RS11840	COG1846	Transcriptional regulator
AY601_RS11845	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AY601_RS11850	COG2195	Cleaves the N-terminal amino acid of tripeptides
AY601_RS11870	COG3685	Protein conserved in bacteria
AY601_RS11880	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AY601_RS11905	COG0745	RESPONSE REGULATOR receiver
AY601_RS11910	COG0076	glutamate decarboxylase activity
AY601_RS11990	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AY601_RS12005	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AY601_RS12020	COG0588	phosphoglycerate mutase activity
AY601_RS12025	COG1132	(ABC) transporter
AY601_RS12030	COG1132	(ABC) transporter
AY601_RS12040	COG0339	signal peptide processing
AY601_RS12050	COG2610	gluconate transmembrane transporter activity
AY601_RS12060	COG2895	sulfate adenylyltransferase (ATP) activity
AY601_RS12065	COG0175	sulfate reduction
AY601_RS12070	COG0175	sulfate reduction
AY601_RS12075	COG0730	response to heat
AY601_RS12080	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AY601_RS12080	COG1648	precorrin-2 dehydrogenase activity
AY601_RS12145	COG0419	ATPase involved in DNA repair
AY601_RS12150	COG0420	3'-5' exonuclease activity
AY601_RS12170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AY601_RS12175	COG1309	transcriptional regulator
AY601_RS12200	COG2322	membrane
AY601_RS12230	COG4206	TonB-dependent receptor
AY601_RS12230	COG1629	transport
AY601_RS12260	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AY601_RS12265	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AY601_RS12270	COG0363	glucosamine-6-phosphate deaminase activity
AY601_RS12295	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AY601_RS12300	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AY601_RS12305	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AY601_RS12320	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AY601_RS12330	COG1666	GTP binding
AY601_RS12365	COG0557	exoribonuclease II activity
AY601_RS12380	COG4565	transcriptional regulatory protein
AY601_RS12390	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AY601_RS12395	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AY601_RS12405	COG1301	dicarboxylic acid transport
AY601_RS12425	COG3525	Glycosyl hydrolase, family 20, catalytic domain
AY601_RS12440	COG0363	glucosamine-6-phosphate deaminase activity
AY601_RS12450	COG0492	ferredoxin-NADP+ reductase activity
AY601_RS12460	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AY601_RS12465	COG1611	Belongs to the LOG family
AY601_RS12480	COG0517	IMP dehydrogenase activity
AY601_RS12480	COG0516	GMP reductase activity
AY601_RS12495	COG0612	Peptidase, M16
AY601_RS12500	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AY601_RS12515	COG3279	Response regulator of the LytR AlgR family
AY601_RS12520	COG2972	Histidine kinase
AY601_RS12520	COG0745	RESPONSE REGULATOR receiver
AY601_RS12545	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AY601_RS12550	COG2264	protein methyltransferase activity
AY601_RS12555	COG0149	triose-phosphate isomerase activity
AY601_RS12565	COG0254	rRNA binding
AY601_RS12575	COG0346	lactoylglutathione lyase activity
AY601_RS12580	COG1104	cysteine desulfurase activity
AY601_RS12590	COG0316	Belongs to the HesB IscA family
AY601_RS12595	COG1022	Amp-dependent synthetase and ligase
AY601_RS12600	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AY601_RS12620	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AY601_RS12640	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AY601_RS12645	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AY601_RS12655	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AY601_RS12660	COG2363	Small membrane protein
AY601_RS12675	COG1214	PFAM Peptidase M22, glycoprotease
AY601_RS12680	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AY601_RS12685	COG0594	ribonuclease P activity
AY601_RS12690	COG3279	Response regulator of the LytR AlgR family
AY601_RS12695	COG3275	phosphorelay sensor kinase activity
AY601_RS12710	COG1970	mechanosensitive ion channel activity
AY601_RS12715	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AY601_RS12720	COG2204	response regulator
AY601_RS12740	COG2204	response regulator
AY601_RS12755	COG3588	fructose-bisphosphate aldolase
AY601_RS12765	COG1733	regulation of RNA biosynthetic process
AY601_RS12775	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AY601_RS12790	COG0561	phosphatase activity
AY601_RS12795	COG1629	transport
AY601_RS12810	COG1595	DNA-templated transcription, initiation
AY601_RS12825	COG0038	chloride channel
AY601_RS12830	COG0673	inositol 2-dehydrogenase activity
AY601_RS12840	COG4771	TonB-dependent receptor
AY601_RS12845	COG0702	epimerase
AY601_RS12855	COG1609	Transcriptional regulator
AY601_RS12870	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AY601_RS12885	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AY601_RS12895	COG4771	TonB-dependent receptor
AY601_RS12900	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AY601_RS12940	COG1252	NADH dehydrogenase
AY601_RS12960	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
AY601_RS12970	COG1063	alcohol dehydrogenase
AY601_RS12980	COG3254	rhamnose metabolic process
AY601_RS12990	COG1733	regulation of RNA biosynthetic process
AY601_RS13005	COG1733	regulation of RNA biosynthetic process
AY601_RS13040	COG3209	COG3209 Rhs family protein
AY601_RS13085	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AY601_RS13095	COG4771	TonB-dependent receptor
AY601_RS13105	COG2188	Transcriptional regulator
AY601_RS13120	COG2814	Major facilitator Superfamily
AY601_RS13140	COG0673	inositol 2-dehydrogenase activity
AY601_RS13150	COG0673	inositol 2-dehydrogenase activity
AY601_RS13170	COG2130	NADP-dependent
AY601_RS13200	COG4682	membrane
AY601_RS13215	COG1741	Belongs to the pirin family
AY601_RS13255	COG1566	PFAM secretion protein HlyD family protein
AY601_RS13300	COG1522	sequence-specific DNA binding
AY601_RS13340	COG2271	Major facilitator Superfamily
AY601_RS13355	COG1028	Short-chain dehydrogenase reductase Sdr
AY601_RS13360	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
AY601_RS13405	COG1733	regulation of RNA biosynthetic process
AY601_RS13410	COG1028	Short-chain dehydrogenase reductase Sdr
AY601_RS13430	COG4771	TonB-dependent receptor
AY601_RS13440	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
AY601_RS13450	COG1309	transcriptional regulator
AY601_RS13460	COG1113	amino acid transport
AY601_RS13475	COG1192	Involved in chromosome partitioning
AY601_RS13510	COG4251	negative regulation of phosphorylation
AY601_RS13515	COG0784	Response regulator, receiver
AY601_RS13520	COG5002	protein histidine kinase activity
AY601_RS13530	COG1733	regulation of RNA biosynthetic process
AY601_RS13535	COG2249	NAD(P)H dehydrogenase (quinone) activity
AY601_RS13545	COG2133	pyrroloquinoline quinone binding
AY601_RS13550	COG1506	peptidase
AY601_RS13550	COG0823	Involved in the tonB-independent uptake of proteins
AY601_RS13560	COG2354	Protein conserved in bacteria
AY601_RS13570	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AY601_RS13585	COG1082	Xylose isomerase domain protein TIM barrel
AY601_RS13635	COG0604	alcohol dehydrogenase
AY601_RS13635	COG3321	synthase
AY601_RS13635	COG1028	Short-chain dehydrogenase reductase Sdr
AY601_RS13660	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AY601_RS13665	COG1917	Cupin 2, conserved barrel domain protein
AY601_RS13665	COG2207	Transcriptional regulator
AY601_RS13675	COG1942	4-Oxalocrotonate Tautomerase
AY601_RS13710	COG3291	Pkd domain containing protein
AY601_RS13725	COG0561	phosphatase activity
AY601_RS13730	COG4771	TonB-dependent receptor
AY601_RS13740	COG2197	response regulator
AY601_RS13760	COG0531	amino acid
AY601_RS13775	COG4771	TonB-dependent receptor
AY601_RS13780	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AY601_RS13785	COG3938	Belongs to the proline racemase family
AY601_RS13795	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AY601_RS13815	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AY601_RS13820	COG3409	Peptidoglycan-binding domain 1 protein
AY601_RS13820	COG0793	Belongs to the peptidase S41A family
AY601_RS13825	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AY601_RS13835	COG4771	TonB-dependent receptor
AY601_RS13850	COG2205	protein histidine kinase activity
AY601_RS13870	COG2814	Major facilitator Superfamily
AY601_RS13875	COG4264	IucA IucC family
AY601_RS13905	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AY601_RS13960	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AY601_RS13965	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AY601_RS13970	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AY601_RS13970	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AY601_RS14015	COG4615	Cyclic peptide transporter
AY601_RS14020	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AY601_RS14065	COG3279	Response regulator of the LytR AlgR family
AY601_RS14115	COG2608	mercury ion transmembrane transporter activity
AY601_RS14125	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AY601_RS14135	COG2217	Heavy metal translocating P-type atpase
AY601_RS14140	COG2132	Multicopper oxidase
AY601_RS14180	COG2814	Major facilitator Superfamily
AY601_RS14235	COG1368	sulfuric ester hydrolase activity
AY601_RS14240	COG2217	Heavy metal translocating P-type atpase
AY601_RS14255	COG1285	pathogenesis
AY601_RS14265	COG0671	phosphoesterase, PA-phosphatase related
AY601_RS14455	COG4206	TonB-dependent receptor
AY601_RS14455	COG1629	transport
AY601_RS14490	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AY601_RS14570	COG1011	Hydrolase
AY601_RS14595	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AY601_RS14615	COG3501	Rhs element vgr protein
AY601_RS14655	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
AY601_RS14660	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AY601_RS14665	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AY601_RS14670	COG1404	Belongs to the peptidase S8 family
AY601_RS14685	COG0436	Aminotransferase
AY601_RS14705	COG0477	Major facilitator Superfamily
AY601_RS14710	COG3507	Belongs to the glycosyl hydrolase 43 family
AY601_RS14715	COG2382	esterase
AY601_RS14725	COG0745	RESPONSE REGULATOR receiver
AY601_RS14725	COG3292	Two component regulator propeller
AY601_RS14725	COG2205	protein histidine kinase activity
AY601_RS14740	COG3661	Belongs to the glycosyl hydrolase 67 family
AY601_RS14745	COG1028	Short-chain dehydrogenase reductase Sdr
AY601_RS14770	COG4771	TonB-dependent receptor
AY601_RS14775	COG5520	Belongs to the glycosyl hydrolase 30 family
AY601_RS14780	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AY601_RS14795	COG2801	Transposase and inactivated derivatives
AY601_RS14820	COG3527	Alpha-acetolactate decarboxylase
AY601_RS14855	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AY601_RS14865	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AY601_RS14895	COG0542	response to heat
AY601_RS14910	COG0438	transferase activity, transferring glycosyl groups
AY601_RS14915	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
AY601_RS14940	COG0778	Nitroreductase
AY601_RS14945	COG0488	(ABC) transporter
AY601_RS14960	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AY601_RS14960	COG5479	isomerase activity
AY601_RS14965	COG0523	cobalamin synthesis protein
AY601_RS14970	COG1136	(ABC) transporter
AY601_RS14985	COG0735	belongs to the Fur family
AY601_RS14995	COG1331	Highly conserved protein containing a thioredoxin domain
AY601_RS15010	COG3757	hydrolase, family 25
AY601_RS15040	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AY601_RS15055	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AY601_RS15055	COG0758	DNA mediated transformation
AY601_RS15060	COG0357	Ribosomal RNA small subunit methyltransferase G
AY601_RS15070	COG0343	queuine tRNA-ribosyltransferase activity
AY601_RS15120	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AY601_RS15130	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AY601_RS15140	COG2153	protein acetylation
AY601_RS15150	COG0191	fructose-bisphosphate aldolase activity
AY601_RS15155	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AY601_RS15185	COG1104	cysteine desulfurase activity
AY601_RS15190	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AY601_RS15195	COG2226	methyltransferase
AY601_RS15200	COG0671	phosphoesterase, PA-phosphatase related
AY601_RS15215	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AY601_RS15220	COG0237	dephospho-CoA kinase activity
AY601_RS15230	COG1862	Preprotein translocase
AY601_RS15240	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AY601_RS15250	COG1132	(ABC) transporter
AY601_RS15290	COG1764	response to oxidative stress
AY601_RS15295	COG2814	Major facilitator Superfamily
AY601_RS15300	COG1506	peptidase
AY601_RS15300	COG0823	Involved in the tonB-independent uptake of proteins
AY601_RS15300	COG4946	Tricorn protease homolog
AY601_RS15320	COG0494	nUDIX hydrolase
AY601_RS15330	COG1028	Short-chain dehydrogenase reductase Sdr
AY601_RS15340	COG1028	Short-chain dehydrogenase reductase Sdr
AY601_RS15355	COG3132	Protein of unknown function, DUF480
AY601_RS15375	COG5002	protein histidine kinase activity
AY601_RS15415	COG3118	belongs to the thioredoxin family
AY601_RS15440	COG1595	DNA-templated transcription, initiation
AY601_RS15485	COG3321	synthase
AY601_RS15485	COG1028	Short-chain dehydrogenase reductase Sdr
AY601_RS15485	COG0604	alcohol dehydrogenase
AY601_RS15510	COG1271	oxidase subunit
AY601_RS15515	COG1252	NADH dehydrogenase
AY601_RS15535	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AY601_RS15540	COG2022	thiamine diphosphate biosynthetic process
AY601_RS15545	COG0352	thiamine-phosphate diphosphorylase activity
AY601_RS15555	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AY601_RS15565	COG2186	Transcriptional regulator
AY601_RS15585	COG0583	DNA-binding transcription factor activity
AY601_RS15590	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AY601_RS15595	COG2205	protein histidine kinase activity
AY601_RS15600	COG2217	Heavy metal translocating P-type atpase
AY601_RS15610	COG3278	Belongs to the heme-copper respiratory oxidase family
AY601_RS15620	COG2010	Cytochrome c
AY601_RS15625	COG0348	domain, Protein
AY601_RS15640	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AY601_RS15650	COG0745	RESPONSE REGULATOR receiver
AY601_RS15655	COG4191	Histidine kinase
AY601_RS15680	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AY601_RS15695	COG2259	Doxx family
AY601_RS15710	COG0484	heat shock protein binding
AY601_RS15715	COG4804	nuclease activity
AY601_RS15720	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AY601_RS15730	COG2205	protein histidine kinase activity
AY601_RS15765	COG0012	GTP binding
AY601_RS15825	COG2239	Acts as a magnesium transporter
AY601_RS15835	COG3279	Response regulator of the LytR AlgR family
AY601_RS15860	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
AY601_RS15880	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AY601_RS15885	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AY601_RS15890	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AY601_RS15895	COG1349	DNA-binding transcription factor activity
AY601_RS15900	COG1607	acyl-coa hydrolase
AY601_RS15905	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
AY601_RS15910	COG1752	Esterase of the alpha-beta hydrolase superfamily
AY601_RS15925	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AY601_RS15940	COG0167	dihydroorotate dehydrogenase activity
AY601_RS15945	COG0488	(ABC) transporter
AY601_RS15955	COG0366	Alpha amylase catalytic
AY601_RS15985	COG2801	Transposase and inactivated derivatives
AY601_RS15995	COG0525	valine-tRNA ligase activity
AY601_RS16000	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AY601_RS16005	COG1506	peptidase
AY601_RS16005	COG0823	Involved in the tonB-independent uptake of proteins
AY601_RS16010	COG3590	peptidase
AY601_RS16020	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AY601_RS16020	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AY601_RS16025	COG0667	Aldo Keto reductase
AY601_RS16030	COG0628	permease
AY601_RS16035	COG3956	TIGRFAM MazG family protein
AY601_RS16040	COG0513	Belongs to the DEAD box helicase family
AY601_RS16045	COG1506	peptidase
AY601_RS16050	COG4591	ABC-type transport system involved in lipoprotein release permease component
AY601_RS16055	COG3876	Protein conserved in bacteria
AY601_RS16065	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
AY601_RS16070	COG1349	DNA-binding transcription factor activity
AY601_RS16080	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AY601_RS16090	COG0564	pseudouridine synthase activity
AY601_RS16095	COG2515	1-aminocyclopropane-1-carboxylate deaminase
AY601_RS16120	COG0702	epimerase
AY601_RS16125	COG1629	transport
AY601_RS16140	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AY601_RS16145	COG1960	acyl-CoA dehydrogenase activity
AY601_RS16155	COG0386	Belongs to the glutathione peroxidase family
AY601_RS16165	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AY601_RS16175	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AY601_RS16180	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AY601_RS16190	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AY601_RS16205	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AY601_RS16220	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AY601_RS16230	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AY601_RS16235	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AY601_RS16245	COG3011	Protein conserved in bacteria
AY601_RS16250	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AY601_RS16255	COG0540	Belongs to the ATCase OTCase family
AY601_RS16275	COG0811	peptide transport
AY601_RS16280	COG0848	biopolymer transport protein
AY601_RS16290	COG0285	dihydrofolate synthase activity
AY601_RS16300	COG1703	isobutyryl-CoA mutase activity
AY601_RS16300	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AY601_RS16300	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AY601_RS16340	COG2963	transposase activity
AY601_RS16345	COG2801	Transposase and inactivated derivatives
AY601_RS16385	COG0497	DNA recombination
AY601_RS16390	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AY601_RS16405	COG0542	response to heat
AY601_RS16440	COG0488	(ABC) transporter
AY601_RS16455	COG0513	Belongs to the DEAD box helicase family
AY601_RS16465	COG3387	PFAM Glycoside hydrolase 15-related
AY601_RS16470	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
AY601_RS16490	COG0004	ammonium transporteR
AY601_RS16500	COG1242	4 iron, 4 sulfur cluster binding
AY601_RS16520	COG0531	amino acid
AY601_RS16530	COG0531	amino acid
AY601_RS16535	COG0531	amino acid
AY601_RS16540	COG2095	MarC family integral membrane protein
AY601_RS16545	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AY601_RS16545	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AY601_RS16555	COG0519	Catalyzes the synthesis of GMP from XMP
AY601_RS16555	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AY601_RS16600	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AY601_RS16615	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AY601_RS16620	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AY601_RS16630	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AY601_RS16635	COG0517	IMP dehydrogenase activity
AY601_RS16645	COG1610	YqeY-like protein
AY601_RS16650	COG4221	oxidoreductase activity
AY601_RS16660	COG2226	methyltransferase
AY601_RS16665	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AY601_RS16670	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AY601_RS16675	COG1164	Oligoendopeptidase f
AY601_RS16680	COG0531	amino acid
AY601_RS16680	COG0531	amino acid
AY601_RS16715	COG0179	Fumarylacetoacetate (FAA) hydrolase
AY601_RS16725	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AY601_RS16740	COG1595	DNA-templated transcription, initiation
AY601_RS16785	COG3118	belongs to the thioredoxin family
AY601_RS16810	COG0745	RESPONSE REGULATOR receiver
AY601_RS16815	COG2205	protein histidine kinase activity
AY601_RS16825	COG3781	membrane
AY601_RS16830	COG0187	DNA topoisomerase II activity
AY601_RS16840	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AY601_RS16855	COG0009	L-threonylcarbamoyladenylate synthase
AY601_RS16860	COG0617	tRNA 3'-terminal CCA addition
AY601_RS16860	COG0517	IMP dehydrogenase activity
AY601_RS16860	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AY601_RS16870	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AY601_RS16880	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AY601_RS16885	COG0085	RNA polymerase activity
AY601_RS16890	COG0222	ribosome binding
AY601_RS16895	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AY601_RS16900	COG0081	regulation of translation
AY601_RS16905	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AY601_RS16955	COG4974	Belongs to the 'phage' integrase family
AY601_RS16960	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AY601_RS16965	COG1960	acyl-CoA dehydrogenase activity
AY601_RS16970	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AY601_RS17025	COG1418	mRNA catabolic process
AY601_RS17045	COG2003	Belongs to the UPF0758 family
AY601_RS17050	COG0268	Binds directly to 16S ribosomal RNA
AY601_RS17055	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AY601_RS17065	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AY601_RS17070	COG0138	bifunctional purine biosynthesis protein purh
AY601_RS17075	COG1077	Cell shape determining protein MreB Mrl
AY601_RS17090	COG0768	penicillin binding
AY601_RS17095	COG0772	Belongs to the SEDS family
AY601_RS17105	COG1435	thymidine kinase activity
AY601_RS17140	COG4771	TonB-dependent receptor
AY601_RS17145	COG0702	epimerase
AY601_RS17170	COG2610	gluconate transmembrane transporter activity
AY601_RS17195	COG3209	COG3209 Rhs family protein
AY601_RS17240	COG1063	alcohol dehydrogenase
AY601_RS17245	COG1012	belongs to the aldehyde dehydrogenase family
AY601_RS17250	COG2207	Transcriptional regulator
AY601_RS17275	COG0247	lactate metabolic process
AY601_RS17275	COG2181	nitrate reductase activity
AY601_RS17280	COG2181	nitrate reductase activity
AY601_RS17280	COG0247	lactate metabolic process
AY601_RS17285	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AY601_RS17295	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AY601_RS17300	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AY601_RS17310	COG0359	binds to the 23S rRNA
AY601_RS17315	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AY601_RS17320	COG0360	Binds together with S18 to 16S ribosomal RNA
AY601_RS17325	COG4206	TonB-dependent receptor
AY601_RS17330	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AY601_RS17340	COG0538	isocitrate dehydrogenase activity
AY601_RS17350	COG4772	TonB-dependent receptor
AY601_RS17355	COG0629	single-stranded DNA binding
AY601_RS17375	COG2814	Major facilitator Superfamily
AY601_RS17380	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AY601_RS17450	COG1132	(ABC) transporter
AY601_RS17465	COG1132	(ABC) transporter
AY601_RS17470	COG1819	glycosyl
AY601_RS17490	COG0564	pseudouridine synthase activity
AY601_RS17495	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AY601_RS17500	COG0505	Belongs to the CarA family
AY601_RS17515	COG0148	phosphopyruvate hydratase activity
AY601_RS17525	COG2860	membrane
AY601_RS17535	COG1028	Short-chain dehydrogenase reductase Sdr
AY601_RS17540	COG2957	Belongs to the agmatine deiminase family
AY601_RS17550	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AY601_RS17550	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AY601_RS17560	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AY601_RS17560	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AY601_RS17565	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AY601_RS17570	COG2963	transposase activity
AY601_RS17575	COG2801	Transposase and inactivated derivatives
AY601_RS17580	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AY601_RS17585	COG1132	(ABC) transporter
AY601_RS17590	COG0101	tRNA pseudouridine synthase activity
AY601_RS17605	COG0405	Gamma-glutamyltransferase
AY601_RS17615	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AY601_RS17640	COG2723	6-phospho-beta-galactosidase activity
AY601_RS17645	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AY601_RS17650	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AY601_RS17660	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AY601_RS17675	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AY601_RS17680	COG1663	tetraacyldisaccharide 4'-kinase activity
AY601_RS17690	COG0288	reversible hydration of carbon dioxide
AY601_RS17695	COG0659	secondary active sulfate transmembrane transporter activity
AY601_RS17710	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AY601_RS17715	COG1363	Peptidase, m42
AY601_RS17725	COG0443	Heat shock 70 kDa protein
AY601_RS17735	COG0203	ribosomal protein L17
AY601_RS17740	COG0202	RNA polymerase activity
AY601_RS17745	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AY601_RS17750	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AY601_RS17755	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AY601_RS17760	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AY601_RS17765	COG0024	Methionine aminopeptidase
AY601_RS17770	COG0201	protein transport
AY601_RS17775	COG0200	Binds to the 23S rRNA
AY601_RS17780	COG1841	ribosomal large subunit assembly
AY601_RS17785	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AY601_RS17790	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AY601_RS17795	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AY601_RS17800	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AY601_RS17805	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AY601_RS17810	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AY601_RS17815	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AY601_RS17820	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AY601_RS17825	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AY601_RS17830	COG0255	Belongs to the universal ribosomal protein uL29 family
AY601_RS17835	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AY601_RS17840	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AY601_RS17845	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AY601_RS17850	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AY601_RS17855	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AY601_RS17860	COG0089	rRNA binding
AY601_RS17865	COG0088	Forms part of the polypeptide exit tunnel
AY601_RS17870	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AY601_RS17880	COG0730	response to heat
AY601_RS17885	COG3177	Filamentation induced by cAMP protein fic
AY601_RS17900	COG0051	transcription antitermination factor activity, RNA binding
AY601_RS17905	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AY601_RS17910	COG0049	tRNA binding
AY601_RS17915	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AY601_RS17920	COG4628	conserved protein (DUF2132)
AY601_RS17930	COG0668	transmembrane transport
AY601_RS17935	COG0318	PFAM AMP-dependent synthetase and ligase
AY601_RS17970	COG1393	Belongs to the ArsC family
AY601_RS17975	COG3275	phosphorelay sensor kinase activity
AY601_RS17985	COG2205	protein histidine kinase activity
AY601_RS17985	COG0784	Response regulator, receiver
AY601_RS17990	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AY601_RS17995	COG2205	protein histidine kinase activity
AY601_RS17995	COG0784	Response regulator, receiver
AY601_RS18000	COG0193	aminoacyl-tRNA hydrolase activity
AY601_RS18005	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AY601_RS18010	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AY601_RS18030	COG0825	malonyl-CoA metabolic process
AY601_RS18045	COG0366	Alpha amylase catalytic
AY601_RS18050	COG1554	hydrolase, family 65, central catalytic
AY601_RS18055	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AY601_RS18060	COG0366	Alpha amylase catalytic
AY601_RS18070	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
AY601_RS18075	COG4206	TonB-dependent receptor
AY601_RS18075	COG1629	transport
AY601_RS18100	COG0142	geranyltranstransferase activity
AY601_RS18105	COG0492	ferredoxin-NADP+ reductase activity
AY601_RS18110	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AY601_RS18110	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AY601_RS18115	COG0252	asparaginase activity
AY601_RS18120	COG0084	hydrolase, TatD family'
AY601_RS18130	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AY601_RS18135	COG0105	UTP biosynthetic process
AY601_RS18140	COG0545	Peptidyl-prolyl cis-trans isomerase
AY601_RS18155	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AY601_RS18170	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AY601_RS18185	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AY601_RS18190	COG1595	DNA-templated transcription, initiation
AY601_RS18200	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AY601_RS18205	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AY601_RS18225	COG1187	pseudouridine synthase activity
AY601_RS18230	COG2706	6-phosphogluconolactonase activity
AY601_RS18235	COG0438	transferase activity, transferring glycosyl groups
AY601_RS18245	COG0037	tRNA processing
AY601_RS18255	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AY601_RS18270	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AY601_RS18275	COG0714	Associated with various cellular activities
AY601_RS18280	COG0584	glycerophosphoryl diester phosphodiesterase
AY601_RS18290	COG0215	cysteine-tRNA ligase activity
AY601_RS18310	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AY601_RS18315	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AY601_RS18330	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AY601_RS18350	COG0778	Nitroreductase
AY601_RS18385	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
AY601_RS18400	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AY601_RS18405	COG1381	Involved in DNA repair and RecF pathway recombination
AY601_RS18455	COG0714	Associated with various cellular activities
AY601_RS18475	COG1629	transport
AY601_RS18495	COG3537	Alpha-1,2-mannosidase
AY601_RS18505	COG4771	TonB-dependent receptor
AY601_RS18520	COG4206	TonB-dependent receptor
AY601_RS18520	COG1629	transport
AY601_RS18535	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AY601_RS18545	COG4948	Mandelate Racemase Muconate Lactonizing
AY601_RS18550	COG0006	proline dipeptidase activity
AY601_RS18565	COG4771	TonB-dependent receptor
AY601_RS18570	COG0702	epimerase
AY601_RS18575	COG1785	Belongs to the alkaline phosphatase family
AY601_RS18595	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AY601_RS18600	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AY601_RS18605	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AY601_RS18630	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AY601_RS18635	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AY601_RS18645	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AY601_RS18655	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AY601_RS18655	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AY601_RS18670	COG1752	Esterase of the alpha-beta hydrolase superfamily
AY601_RS18675	COG2045	Belongs to the ComB family
AY601_RS18680	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AY601_RS18690	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AY601_RS18695	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AY601_RS18710	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AY601_RS18720	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
AY601_RS18725	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AY601_RS18730	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AY601_RS18735	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AY601_RS18740	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AY601_RS18745	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AY601_RS18750	COG0356	it plays a direct role in the translocation of protons across the membrane
AY601_RS18775	COG0322	excinuclease ABC activity
AY601_RS18795	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AY601_RS18815	COG3177	Filamentation induced by cAMP protein fic
AY601_RS18820	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AY601_RS18825	COG0300	oxidoreductase activity
AY601_RS18830	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
AY601_RS18865	COG0745	RESPONSE REGULATOR receiver
AY601_RS18895	COG1360	Flagellar Motor Protein
AY601_RS18915	COG2322	membrane
AY601_RS18930	COG1845	cytochrome c oxidase, subunit III
AY601_RS18935	COG1845	cytochrome c oxidase, subunit III
AY601_RS18940	COG0109	protoheme IX farnesyltransferase activity
AY601_RS18950	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AY601_RS18980	COG0437	4 iron, 4 sulfur cluster binding
AY601_RS19015	COG2755	lipolytic protein G-D-S-L family
AY601_RS19015	COG0657	acetylesterase activity
AY601_RS19020	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AY601_RS19030	COG0166	Belongs to the GPI family
AY601_RS19045	COG0792	nuclease activity
AY601_RS19050	COG0358	DNA primase activity
AY601_RS19070	COG1473	amidohydrolase
AY601_RS19080	COG0653	protein targeting
AY601_RS19085	COG0151	Belongs to the GarS family
AY601_RS19110	COG0010	Belongs to the arginase family
AY601_RS19115	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AY601_RS19155	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AY601_RS19160	COG2204	response regulator
AY601_RS19180	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AY601_RS19185	COG0459	protein refolding
AY601_RS19200	COG1285	pathogenesis
AY601_RS19205	COG1760	l-serine dehydratase
AY601_RS19225	COG0321	lipoyl(octanoyl) transferase activity
AY601_RS19235	COG0717	Belongs to the dCTP deaminase family
AY601_RS19240	COG4771	TonB-dependent receptor
AY601_RS19250	COG1028	Short-chain dehydrogenase reductase Sdr
AY601_RS19255	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AY601_RS19275	COG0494	nUDIX hydrolase
AY601_RS19285	COG3279	Response regulator of the LytR AlgR family
AY601_RS19290	COG2972	Histidine kinase
AY601_RS19305	COG4771	TonB-dependent receptor
AY601_RS19315	COG1053	succinate dehydrogenase
AY601_RS19325	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AY601_RS19330	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AY601_RS19335	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AY601_RS19360	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AY601_RS19360	COG0116	Belongs to the methyltransferase superfamily
AY601_RS19370	COG1418	mRNA catabolic process
AY601_RS19385	COG5002	protein histidine kinase activity
AY601_RS19395	COG0306	phosphate transporter
AY601_RS19415	COG0513	Belongs to the DEAD box helicase family
AY601_RS19420	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AY601_RS19425	COG2885	chlorophyll binding
AY601_RS19425	COG3047	cAMP biosynthetic process
AY601_RS19435	COG0673	inositol 2-dehydrogenase activity
AY601_RS19445	COG2267	carboxylic ester hydrolase activity
AY601_RS19450	COG4771	TonB-dependent receptor
AY601_RS19465	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AY601_RS19470	COG0702	epimerase
AY601_RS19485	COG0124	histidyl-tRNA synthetase
AY601_RS19490	COG0508	dehydrogenase complex catalyzes the overall conversion of
AY601_RS19495	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AY601_RS19500	COG0791	NLP P60 protein
AY601_RS19530	COG1446	asparaginase
AY601_RS19560	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AY601_RS19580	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AY601_RS19585	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AY601_RS19595	COG0251	oxidation-reduction process
AY601_RS19605	COG0006	proline dipeptidase activity
AY601_RS19625	COG1132	(ABC) transporter
AY601_RS19635	COG1215	transferase activity, transferring glycosyl groups
AY601_RS19640	COG1216	Glycosyl transferase, family 2
AY601_RS19645	COG1215	transferase activity, transferring glycosyl groups
AY601_RS19665	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AY601_RS19670	COG0195	Participates in both transcription termination and antitermination
AY601_RS19675	COG0779	Required for maturation of 30S ribosomal subunits
AY601_RS19685	COG1950	PFAM Membrane protein of
AY601_RS19690	COG1960	acyl-CoA dehydrogenase activity
AY601_RS19695	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AY601_RS19700	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AY601_RS19705	COG0297	glycogen (starch) synthase activity
AY601_RS19720	COG1194	a g-specific adenine glycosylase
AY601_RS19725	COG0776	regulation of translation
AY601_RS19735	COG1530	ribonuclease E activity
AY601_RS19740	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AY601_RS19745	COG3158	transport of potassium into the cell
AY601_RS19755	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AY601_RS19765	COG3201	nicotinamide mononucleotide transporter
AY601_RS19780	COG0352	thiamine-phosphate diphosphorylase activity
AY601_RS19790	COG1132	(ABC) transporter
AY601_RS19795	COG0233	cytoplasmic translational termination
AY601_RS19800	COG0528	UMP kinase activity
AY601_RS19805	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AY601_RS19810	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AY601_RS19815	COG0052	Belongs to the universal ribosomal protein uS2 family
AY601_RS19820	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AY601_RS19840	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AY601_RS19860	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AY601_RS19890	COG4948	Mandelate Racemase Muconate Lactonizing
AY601_RS19930	COG1629	transport
AY601_RS19930	COG4206	TonB-dependent receptor
AY601_RS19935	COG3275	phosphorelay sensor kinase activity
AY601_RS19940	COG3279	Response regulator of the LytR AlgR family
AY601_RS19955	COG1538	Outer membrane efflux protein
AY601_RS19960	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AY601_RS19985	COG0754	glutathionylspermidine amidase activity
AY601_RS19990	COG1064	alcohol dehydrogenase
AY601_RS20010	COG3772	lysozyme
AY601_RS20375	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AY601_RS20375	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AY601_RS20390	COG1629	transport
AY601_RS20395	COG1619	proteins homologs of microcin C7 resistance protein MccF
AY601_RS20405	COG4771	TonB-dependent receptor
AY601_RS20415	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AY601_RS20425	COG1774	PSP1 C-terminal conserved region
AY601_RS20430	COG0470	DNA polymerase III
AY601_RS20435	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AY601_RS20445	COG1705	Flagellar rod assembly protein muramidase FlgJ
AY601_RS20450	COG0791	NLP P60 protein
AY601_RS20450	COG1388	LysM domain
AY601_RS20470	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AY601_RS20475	COG0606	chelatase, subunit chli
AY601_RS20480	COG2249	NAD(P)H dehydrogenase (quinone) activity
AY601_RS20485	COG1733	regulation of RNA biosynthetic process
AY601_RS20490	COG1091	dTDP-4-dehydrorhamnose reductase activity
AY601_RS20495	COG1733	regulation of RNA biosynthetic process
AY601_RS20515	COG0606	chelatase, subunit chli
AY601_RS20545	COG0326	Molecular chaperone. Has ATPase activity
AY601_RS20560	COG0612	Peptidase, M16
AY601_RS20565	COG0242	peptide deformylase activity
AY601_RS20575	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AY601_RS20580	COG0489	protein tyrosine kinase activity
AY601_RS20585	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AY601_RS20590	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
AY601_RS20595	COG0688	phosphatidylethanolamine metabolic process
AY601_RS20600	COG0335	large ribosomal subunit rRNA binding
AY601_RS20610	COG0336	Belongs to the RNA methyltransferase TrmD family
AY601_RS20615	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AY601_RS20620	COG0228	four-way junction DNA binding
AY601_RS20625	COG0205	6-phosphofructokinase activity
AY601_RS20630	COG4232	protein-disulfide reductase activity
AY601_RS20650	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AY601_RS20655	COG1556	Lactate utilization protein
AY601_RS20710	COG3525	Glycosyl hydrolase, family 20, catalytic domain
AY601_RS20715	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AY601_RS20730	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AY601_RS20745	COG4589	Belongs to the CDS family
AY601_RS20760	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AY601_RS20765	COG2967	ApaG domain
AY601_RS20780	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AY601_RS20785	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AY601_RS20790	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AY601_RS20805	COG0445	tRNA wobble uridine modification
AY601_RS20810	COG0488	(ABC) transporter
AY601_RS20815	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AY601_RS20825	COG1278	Cold shock
AY601_RS20855	COG0802	atpase or kinase
AY601_RS20865	COG1078	dGTPase activity
AY601_RS20870	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AY601_RS20875	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AY601_RS20875	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AY601_RS20880	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AY601_RS20885	COG1121	(ABC) transporter
AY601_RS20890	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AY601_RS20900	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AY601_RS20905	COG0708	Exodeoxyribonuclease III
AY601_RS20935	COG2353	YceI-like domain
AY601_RS20940	COG3384	dioxygenase
AY601_RS20960	COG1309	transcriptional regulator
AY601_RS20980	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AY601_RS20985	COG2814	Major facilitator Superfamily
AY601_RS21000	COG1309	transcriptional regulator
AY601_RS21015	COG2076	Multidrug Resistance protein
AY601_RS21040	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AY601_RS21045	COG2321	neutral zinc metallopeptidase
AY601_RS21055	COG2205	protein histidine kinase activity
AY601_RS21055	COG0784	Response regulator, receiver
AY601_RS21065	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AY601_RS21075	COG0745	RESPONSE REGULATOR receiver
AY601_RS21090	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AY601_RS21095	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AY601_RS21095	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AY601_RS21100	COG1024	Enoyl-CoA hydratase
AY601_RS21105	COG2204	response regulator
AY601_RS21125	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AY601_RS21145	COG0861	Integral membrane protein TerC family
AY601_RS21155	COG3781	membrane
AY601_RS21165	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AY601_RS21180	COG0583	DNA-binding transcription factor activity
AY601_RS21185	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AY601_RS21190	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AY601_RS21205	COG2818	Glycosylase
AY601_RS21215	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AY601_RS21215	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AY601_RS21220	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AY601_RS21230	COG1902	pentaerythritol trinitrate reductase activity
AY601_RS21235	COG2234	aminopeptidase activity
AY601_RS21245	COG0137	argininosuccinate synthase activity
AY601_RS21250	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AY601_RS21265	COG0596	Alpha beta hydrolase
AY601_RS21270	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AY601_RS21275	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AY601_RS21280	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AY601_RS21285	COG0165	Argininosuccinate lyase
AY601_RS21295	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AY601_RS21305	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AY601_RS21310	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AY601_RS21315	COG0194	GDP metabolic process
AY601_RS21320	COG1561	YicC-like family, N-terminal region
AY601_RS21330	COG0571	ribonuclease III activity
AY601_RS21335	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AY601_RS21340	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AY601_RS21350	COG0469	pyruvate kinase activity
AY601_RS21365	COG3279	Response regulator of the LytR AlgR family
AY601_RS21370	COG0247	lactate metabolic process
AY601_RS21375	COG1139	Iron-sulfur cluster binding protein
AY601_RS21380	COG1556	Lactate utilization protein
AY601_RS21395	COG1472	Belongs to the glycosyl hydrolase 3 family
AY601_RS21405	COG1959	2 iron, 2 sulfur cluster binding
AY601_RS21415	COG1074	ATP-dependent DNA helicase activity
AY601_RS21425	COG0022	dehydrogenase e1 component
AY601_RS21425	COG0508	dehydrogenase complex catalyzes the overall conversion of
AY601_RS21430	COG2183	response to ionizing radiation
AY601_RS21500	COG1522	sequence-specific DNA binding
AY601_RS21515	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AY601_RS21520	COG0512	Glutamine amidotransferase of anthranilate synthase
AY601_RS21525	COG0134	indole-3-glycerol-phosphate synthase activity
AY601_RS21530	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AY601_RS21535	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AY601_RS21575	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AY601_RS21580	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AY601_RS21610	COG1809	phosphosulfolactate synthase activity
AY601_RS21615	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AY601_RS21625	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AY601_RS21640	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
AY601_RS21655	COG0302	gtp cyclohydrolase
AY601_RS21660	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AY601_RS21665	COG5000	phosphorelay sensor kinase activity
AY601_RS21675	COG1649	PFAM Uncharacterised BCR, COG1649
AY601_RS21680	COG0612	Peptidase, M16
AY601_RS21685	COG0363	glucosamine-6-phosphate deaminase activity
AY601_RS21690	COG1131	(ABC) transporter
AY601_RS21705	COG0793	Belongs to the peptidase S41A family
AY601_RS21715	COG0492	ferredoxin-NADP+ reductase activity
AY601_RS21725	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AY601_RS21805	COG1216	Glycosyl transferase, family 2
AY601_RS21840	COG0438	transferase activity, transferring glycosyl groups
AY601_RS21865	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AY601_RS21910	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
AY601_RS21915	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AY601_RS21920	COG1597	lipid kinase activity
AY601_RS21930	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
AY601_RS21935	COG0811	peptide transport
AY601_RS21950	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
AY601_RS21975	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AY601_RS21980	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AY601_RS21990	COG0649	NAD binding
AY601_RS21995	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
AY601_RS22005	COG1034	ATP synthesis coupled electron transport
AY601_RS22010	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AY601_RS22015	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AY601_RS22020	COG0839	Belongs to the complex I subunit 6 family
AY601_RS22025	COG0713	ATP synthesis coupled electron transport
AY601_RS22030	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AY601_RS22035	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AY601_RS22040	COG1007	ATP synthesis coupled electron transport
AY601_RS22045	COG0586	Pfam SNARE associated Golgi protein
AY601_RS22055	COG1253	flavin adenine dinucleotide binding
AY601_RS22060	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AY601_RS22070	COG4770	biotin carboxylase activity
AY601_RS22075	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AY601_RS22085	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AY601_RS22100	COG2353	YceI-like domain
AY601_RS22120	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AY601_RS22140	COG0702	epimerase
AY601_RS22145	COG1217	gtp-binding protein TYPA
AY601_RS22150	COG0300	oxidoreductase activity
AY601_RS22220	COG1011	Hydrolase
AY601_RS22225	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AY601_RS22235	COG0556	nucleotide-excision repair
AY601_RS22240	COG4895	conserved protein (DUF2196)
AY601_RS22270	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AY601_RS22285	COG1629	transport
AY601_RS22295	COG4771	TonB-dependent receptor
AY601_RS22300	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AY601_RS22345	COG3275	phosphorelay sensor kinase activity
AY601_RS22350	COG3279	Response regulator of the LytR AlgR family
AY601_RS22355	COG2198	Histidine kinase
AY601_RS22355	COG0784	Response regulator, receiver
AY601_RS22355	COG5002	protein histidine kinase activity
AY601_RS22375	COG1858	cytochrome C peroxidase
AY601_RS22400	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AY601_RS22420	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
AY601_RS22435	COG2244	polysaccharide biosynthetic process
AY601_RS22480	COG1216	Glycosyl transferase, family 2
AY601_RS22485	COG0110	maltose O-acetyltransferase activity
AY601_RS22500	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AY601_RS22530	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AY601_RS22555	COG2205	protein histidine kinase activity
AY601_RS22555	COG2202	Pas domain
AY601_RS22565	COG2201	protein-glutamate methylesterase activity
AY601_RS22570	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AY601_RS22580	COG2197	response regulator
AY601_RS22620	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AY601_RS22625	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AY601_RS22630	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AY601_RS22635	COG2198	Histidine kinase
AY601_RS22635	COG5002	protein histidine kinase activity
AY601_RS22635	COG0784	Response regulator, receiver
AY601_RS22645	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AY601_RS22650	COG1187	pseudouridine synthase activity
AY601_RS22670	COG3328	transposase activity
AY601_RS22680	COG0402	S-adenosylhomocysteine deaminase activity
AY601_RS22690	COG1254	Belongs to the acylphosphatase family
AY601_RS22700	COG0756	dUTP diphosphatase activity
AY601_RS22720	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AY601_RS22725	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AY601_RS22730	COG0154	amidase activity
AY601_RS22735	COG1705	Flagellar rod assembly protein muramidase FlgJ
AY601_RS22735	COG1388	LysM domain
AY601_RS22740	COG0281	malic enzyme
AY601_RS22740	COG0280	phosphate acetyltransferase
AY601_RS22745	COG0632	four-way junction helicase activity
AY601_RS22755	COG0509	glycine decarboxylation via glycine cleavage system
AY601_RS22770	COG4774	siderophore transport
AY601_RS22795	COG0022	dehydrogenase e1 component
AY601_RS22800	COG1139	Iron-sulfur cluster binding protein
AY601_RS22810	COG0698	ribose 5-phosphate isomerase
AY601_RS22815	COG0805	protein transport
AY601_RS22820	COG0439	Biotin carboxylase
AY601_RS22825	COG0511	ligase activity, forming carbon-carbon bonds
AY601_RS22830	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AY601_RS22835	COG0416	fatty acid biosynthetic process
AY601_RS22840	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AY601_RS22850	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AY601_RS22855	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AY601_RS22860	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AY601_RS22880	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AY601_RS22885	COG0537	adenosine 5'-monophosphoramidase activity
AY601_RS22890	COG1694	Mazg nucleotide pyrophosphohydrolase
AY601_RS22900	COG1162	GTPase activity
AY601_RS22905	COG0527	aspartate kinase activity
AY601_RS22905	COG0460	homoserine dehydrogenase
AY601_RS22910	COG0083	homoserine kinase activity
AY601_RS22930	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AY601_RS22940	COG0670	Belongs to the BI1 family
AY601_RS22950	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AY601_RS22955	COG0793	Belongs to the peptidase S41A family
AY601_RS22960	COG1160	GTP binding
AY601_RS22965	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AY601_RS23005	COG3325	Belongs to the glycosyl hydrolase 18 family
AY601_RS23005	COG3469	chitinase activity
AY601_RS23045	COG0784	Response regulator, receiver
AY601_RS23045	COG2205	protein histidine kinase activity
AY601_RS23050	COG2204	response regulator
AY601_RS23075	COG1959	2 iron, 2 sulfur cluster binding
AY601_RS23080	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AY601_RS23080	COG1648	precorrin-2 dehydrogenase activity
AY601_RS23085	COG1404	Belongs to the peptidase S8 family
AY601_RS23105	COG2885	chlorophyll binding
AY601_RS23110	COG0745	RESPONSE REGULATOR receiver
AY601_RS23120	COG1979	alcohol dehydrogenase
AY601_RS23155	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AY601_RS23160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AY601_RS23175	COG1022	Amp-dependent synthetase and ligase
AY601_RS23190	COG1024	Enoyl-CoA hydratase
AY601_RS23190	COG1250	3-hydroxyacyl-CoA dehydrogenase
AY601_RS23195	COG0183	Belongs to the thiolase family
AY601_RS23200	COG1960	acyl-CoA dehydrogenase activity
AY601_RS23205	COG0545	Peptidyl-prolyl cis-trans isomerase
AY601_RS23220	COG0415	Belongs to the DNA photolyase family
AY601_RS23225	COG1090	epimerase
AY601_RS23230	COG0415	Belongs to the DNA photolyase family
AY601_RS23240	COG0567	Dehydrogenase, E1 component
AY601_RS23245	COG0508	dehydrogenase complex catalyzes the overall conversion of
AY601_RS23260	COG3328	transposase activity
AY601_RS23305	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AY601_RS23325	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AY601_RS23330	COG1595	DNA-templated transcription, initiation
AY601_RS23410	COG2202	Pas domain
AY601_RS23410	COG3920	Histidine kinase
AY601_RS23425	COG3708	Transcriptional regulator
AY601_RS23440	COG2186	Transcriptional regulator
AY601_RS23445	COG2223	nitrite transmembrane transporter activity
AY601_RS23470	COG3852	Histidine kinase
AY601_RS23480	COG3511	phospholipase C
AY601_RS23485	COG5002	protein histidine kinase activity
AY601_RS23495	COG1137	ATPase activity
AY601_RS23500	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AY601_RS23500	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AY601_RS23505	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AY601_RS23510	COG2198	Histidine kinase
AY601_RS23510	COG0784	Response regulator, receiver
AY601_RS23510	COG0643	Histidine kinase
AY601_RS23515	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AY601_RS23515	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AY601_RS23520	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AY601_RS23530	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AY601_RS23615	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AY601_RS23630	COG0601	transmembrane transport
AY601_RS23635	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AY601_RS23645	COG0101	tRNA pseudouridine synthase activity
AY601_RS23650	COG3525	Glycosyl hydrolase, family 20, catalytic domain
AY601_RS23660	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AY601_RS23675	COG2211	Major facilitator Superfamily
AY601_RS23685	COG0673	inositol 2-dehydrogenase activity
AY601_RS23700	COG0673	inositol 2-dehydrogenase activity
AY601_RS23715	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AY601_RS23720	COG0217	transcriptional regulatory protein
AY601_RS23730	COG0702	epimerase
AY601_RS23735	COG4771	TonB-dependent receptor
AY601_RS23755	COG0702	epimerase
AY601_RS23760	COG4771	TonB-dependent receptor
AY601_RS23770	COG1054	Belongs to the UPF0176 family
AY601_RS23835	COG0726	polysaccharide deacetylase
AY601_RS23840	COG0463	Glycosyl transferase, family 2
AY601_RS23855	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AY601_RS23860	COG0387	Pfam Sodium calcium exchanger
AY601_RS23885	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AY601_RS23920	COG4771	TonB-dependent receptor
AY601_RS23940	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AY601_RS23970	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AY601_RS23970	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AY601_RS23980	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AY601_RS23990	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AY601_RS23995	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AY601_RS24010	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AY601_RS24035	COG4651	solute:proton antiporter activity
AY601_RS24035	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AY601_RS24045	COG0196	riboflavin kinase activity
AY601_RS24050	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AY601_RS24055	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AY601_RS24060	COG1968	undecaprenyl-diphosphatase activity
AY601_RS24070	COG2177	Part of the ABC transporter FtsEX involved in
AY601_RS24075	COG0495	leucyl-tRNA aminoacylation
AY601_RS24095	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AY601_RS24100	COG1192	Involved in chromosome partitioning
AY601_RS24105	COG1475	DNA binding
AY601_RS24115	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AY601_RS24120	COG0681	Belongs to the peptidase S26 family
AY601_RS24130	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
AY601_RS24135	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AY601_RS24140	COG0552	protein localization to endoplasmic reticulum
AY601_RS24145	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AY601_RS24150	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AY601_RS24155	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AY601_RS24160	COG3237	CsbD-like
AY601_RS24185	COG0612	Peptidase, M16
AY601_RS24190	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AY601_RS24200	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AY601_RS24205	COG0745	RESPONSE REGULATOR receiver
AY601_RS24220	COG1917	Cupin 2, conserved barrel domain protein
AY601_RS24220	COG2169	Transcriptional regulator
AY601_RS24230	COG0745	RESPONSE REGULATOR receiver
AY601_RS24240	COG2003	Belongs to the UPF0758 family
AY601_RS24320	COG2267	carboxylic ester hydrolase activity
AY601_RS24335	COG2972	Histidine kinase
AY601_RS24345	COG4771	TonB-dependent receptor
AY601_RS24355	COG3279	Response regulator of the LytR AlgR family
AY601_RS24360	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
AY601_RS24405	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AY601_RS24425	COG0738	Major facilitator superfamily
AY601_RS24430	COG3618	amidohydrolase
AY601_RS24450	COG1321	iron dependent repressor
AY601_RS24475	COG2226	methyltransferase
AY601_RS24480	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AY601_RS24495	COG1131	(ABC) transporter
AY601_RS24550	COG0471	metal ion transport
AY601_RS24560	COG1053	succinate dehydrogenase
AY601_RS24565	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AY601_RS24575	COG1309	transcriptional regulator
AY601_RS24610	COG0513	Belongs to the DEAD box helicase family
AY601_RS24620	COG0531	amino acid
AY601_RS24630	COG1295	ribonuclease BN
AY601_RS24635	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AY601_RS24675	COG0116	Belongs to the methyltransferase superfamily
AY601_RS24675	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AY601_RS24680	COG1127	ABC transporter
AY601_RS24685	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AY601_RS24700	COG1714	RDD family
AY601_RS24705	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AY601_RS24715	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AY601_RS24720	COG0181	hydroxymethylbilane synthase activity
AY601_RS24725	COG0113	porphobilinogen synthase activity
AY601_RS24730	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AY601_RS24735	COG5002	protein histidine kinase activity
AY601_RS24740	COG0745	RESPONSE REGULATOR receiver
AY601_RS24750	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AY601_RS24755	COG1981	membrane
AY601_RS24795	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AY601_RS24800	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AY601_RS24805	COG0473	3-isopropylmalate dehydrogenase activity
AY601_RS24810	COG1119	ATPase activity
AY601_RS24815	COG0066	3-isopropylmalate dehydratase activity
AY601_RS24820	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AY601_RS24825	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AY601_RS24830	COG0440	acetolactate synthase activity
AY601_RS24835	COG0028	Belongs to the TPP enzyme family
AY601_RS24855	COG0577	efflux transmembrane transporter activity
AY601_RS24860	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AY601_RS24865	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AY601_RS24915	COG1629	transport
AY601_RS24920	COG0702	epimerase
AY601_RS24945	COG0673	inositol 2-dehydrogenase activity
AY601_RS24960	COG1309	transcriptional regulator
AY601_RS24970	COG2814	Major facilitator Superfamily
AY601_RS24975	COG0563	adenylate kinase activity
AY601_RS24980	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AY601_RS24985	COG0659	secondary active sulfate transmembrane transporter activity
AY601_RS24990	COG3781	membrane
AY601_RS24995	COG2003	Belongs to the UPF0758 family
AY601_RS25090	COG0024	Methionine aminopeptidase
AY601_RS25100	COG0156	8-amino-7-oxononanoate synthase activity
AY601_RS25105	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AY601_RS25115	COG1309	transcriptional regulator
AY601_RS25125	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AY601_RS25140	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AY601_RS25150	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AY601_RS25155	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AY601_RS25175	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AY601_RS25205	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AY601_RS25205	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly