locus-tag	class	description
H9L23_RS00005	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
H9L23_RS00015	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H9L23_RS00030	COG1136	(ABC) transporter
H9L23_RS00030	COG0577	efflux transmembrane transporter activity
H9L23_RS00035	COG0316	Belongs to the HesB IscA family
H9L23_RS00045	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H9L23_RS00045	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H9L23_RS00050	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H9L23_RS00055	COG0494	nUDIX hydrolase
H9L23_RS00080	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
H9L23_RS00135	COG2354	Protein conserved in bacteria
H9L23_RS00170	COG0726	polysaccharide deacetylase
H9L23_RS00175	COG0463	Glycosyl transferase, family 2
H9L23_RS00190	COG4771	TonB-dependent receptor
H9L23_RS00205	COG0823	Involved in the tonB-independent uptake of proteins
H9L23_RS00225	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H9L23_RS00245	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
H9L23_RS00260	COG2205	protein histidine kinase activity
H9L23_RS00265	COG1028	Short-chain dehydrogenase reductase Sdr
H9L23_RS00280	COG0745	RESPONSE REGULATOR receiver
H9L23_RS00290	COG1028	Short-chain dehydrogenase reductase Sdr
H9L23_RS00315	COG1733	regulation of RNA biosynthetic process
H9L23_RS00320	COG1028	Short-chain dehydrogenase reductase Sdr
H9L23_RS00325	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H9L23_RS00355	COG0667	Aldo Keto reductase
H9L23_RS00560	COG2855	membrane
H9L23_RS00570	COG0725	ABC transporter, periplasmic molybdate-binding protein
H9L23_RS00580	COG3258	Cytochrome c
H9L23_RS00585	COG0583	DNA-binding transcription factor activity
H9L23_RS00600	COG0038	chloride channel
H9L23_RS00605	COG0148	phosphopyruvate hydratase activity
H9L23_RS00655	COG0745	RESPONSE REGULATOR receiver
H9L23_RS00670	COG3258	Cytochrome c
H9L23_RS00675	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H9L23_RS00705	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H9L23_RS00710	COG0730	response to heat
H9L23_RS00750	COG2132	Multicopper oxidase
H9L23_RS00755	COG2217	Heavy metal translocating P-type atpase
H9L23_RS00765	COG2217	Heavy metal translocating P-type atpase
H9L23_RS00785	COG1247	-acetyltransferase
H9L23_RS00790	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H9L23_RS00795	COG0798	PFAM Bile acid sodium symporter
H9L23_RS00880	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
H9L23_RS00900	COG3279	Response regulator of the LytR AlgR family
H9L23_RS00910	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H9L23_RS00915	COG1629	transport
H9L23_RS00915	COG4206	TonB-dependent receptor
H9L23_RS01135	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H9L23_RS01135	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H9L23_RS01145	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H9L23_RS01150	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H9L23_RS01155	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H9L23_RS01170	COG2814	Major facilitator Superfamily
H9L23_RS01220	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H9L23_RS01235	COG4771	TonB-dependent receptor
H9L23_RS01245	COG3292	Two component regulator propeller
H9L23_RS01245	COG2205	protein histidine kinase activity
H9L23_RS01245	COG0745	RESPONSE REGULATOR receiver
H9L23_RS01250	COG4771	TonB-dependent receptor
H9L23_RS01255	COG0702	epimerase
H9L23_RS01265	COG5492	domain, Protein
H9L23_RS01270	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
H9L23_RS01280	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
H9L23_RS01285	COG1028	Short-chain dehydrogenase reductase Sdr
H9L23_RS01290	COG0288	reversible hydration of carbon dioxide
H9L23_RS01295	COG0655	NAD(P)H dehydrogenase (quinone) activity
H9L23_RS01395	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
H9L23_RS01415	COG4771	TonB-dependent receptor
H9L23_RS01420	COG0702	epimerase
H9L23_RS01430	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H9L23_RS01445	COG3275	phosphorelay sensor kinase activity
H9L23_RS01455	COG4771	TonB-dependent receptor
H9L23_RS01460	COG0702	epimerase
H9L23_RS01465	COG4771	TonB-dependent receptor
H9L23_RS01475	COG1609	Transcriptional regulator
H9L23_RS01530	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H9L23_RS01550	COG1506	peptidase
H9L23_RS01550	COG4946	Tricorn protease homolog
H9L23_RS01550	COG0823	Involved in the tonB-independent uptake of proteins
H9L23_RS01565	COG2204	response regulator
H9L23_RS01575	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H9L23_RS01590	COG3537	Alpha-1,2-mannosidase
H9L23_RS01605	COG4335	DNA alkylation repair
H9L23_RS01620	COG0730	response to heat
H9L23_RS01625	COG2186	Transcriptional regulator
H9L23_RS01670	COG2610	gluconate transmembrane transporter activity
H9L23_RS01680	COG2169	Transcriptional regulator
H9L23_RS01680	COG1917	Cupin 2, conserved barrel domain protein
H9L23_RS01710	COG4181	ATPase activity
H9L23_RS01810	COG0702	epimerase
H9L23_RS01815	COG1629	transport
H9L23_RS01820	COG1882	Formate acetyltransferase
H9L23_RS01835	COG0563	adenylate kinase activity
H9L23_RS01840	COG4771	TonB-dependent receptor
H9L23_RS01875	COG3685	Protein conserved in bacteria
H9L23_RS01885	COG1595	DNA-templated transcription, initiation
H9L23_RS01890	COG3119	arylsulfatase activity
H9L23_RS01895	COG3119	arylsulfatase activity
H9L23_RS01900	COG1373	ATPase (AAA superfamily
H9L23_RS01905	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H9L23_RS01910	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H9L23_RS01915	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H9L23_RS01925	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
H9L23_RS01985	COG3437	response regulator, receiver
H9L23_RS01990	COG3292	Two component regulator propeller
H9L23_RS01990	COG2205	protein histidine kinase activity
H9L23_RS01990	COG0745	RESPONSE REGULATOR receiver
H9L23_RS02000	COG4771	TonB-dependent receptor
H9L23_RS02020	COG3940	Belongs to the glycosyl hydrolase 43 family
H9L23_RS02035	COG3507	Belongs to the glycosyl hydrolase 43 family
H9L23_RS02045	COG0456	acetyltransferase
H9L23_RS02075	COG0745	RESPONSE REGULATOR receiver
H9L23_RS02075	COG3292	Two component regulator propeller
H9L23_RS02075	COG2205	protein histidine kinase activity
H9L23_RS02080	COG2814	Major facilitator Superfamily
H9L23_RS02090	COG4771	TonB-dependent receptor
H9L23_RS02100	COG1621	beta-fructofuranosidase activity
H9L23_RS02120	COG1028	Short-chain dehydrogenase reductase Sdr
H9L23_RS02135	COG4876	unkown
H9L23_RS02140	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H9L23_RS02195	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H9L23_RS02270	COG1228	amidohydrolase
H9L23_RS02275	COG3118	belongs to the thioredoxin family
H9L23_RS02285	COG1629	transport
H9L23_RS02310	COG3279	Response regulator of the LytR AlgR family
H9L23_RS02380	COG0702	epimerase
H9L23_RS02385	COG1733	regulation of RNA biosynthetic process
H9L23_RS02520	COG0739	heme binding
H9L23_RS02565	COG0584	glycerophosphoryl diester phosphodiesterase
H9L23_RS02570	COG3340	Belongs to the peptidase S51 family
H9L23_RS02575	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H9L23_RS02585	COG0110	maltose O-acetyltransferase activity
H9L23_RS02610	COG0438	transferase activity, transferring glycosyl groups
H9L23_RS02650	COG0463	Glycosyl transferase, family 2
H9L23_RS02680	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H9L23_RS02685	COG2226	methyltransferase
H9L23_RS02700	COG1216	Glycosyl transferase, family 2
H9L23_RS02730	COG0438	transferase activity, transferring glycosyl groups
H9L23_RS02745	COG0489	protein tyrosine kinase activity
H9L23_RS02770	COG0463	Glycosyl transferase, family 2
H9L23_RS02775	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H9L23_RS02780	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H9L23_RS02790	COG3119	arylsulfatase activity
H9L23_RS02800	COG0126	phosphoglycerate kinase activity
H9L23_RS02810	COG1629	transport
H9L23_RS02835	COG3525	Glycosyl hydrolase, family 20, catalytic domain
H9L23_RS02840	COG2001	Belongs to the MraZ family
H9L23_RS02845	COG0275	rRNA processing
H9L23_RS02855	COG0768	penicillin binding
H9L23_RS02860	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H9L23_RS02865	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H9L23_RS02870	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H9L23_RS02875	COG0772	Belongs to the SEDS family
H9L23_RS02880	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H9L23_RS02885	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H9L23_RS02900	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H9L23_RS02905	COG0156	8-amino-7-oxononanoate synthase activity
H9L23_RS02930	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H9L23_RS02935	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H9L23_RS02950	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H9L23_RS02960	COG0523	cobalamin synthesis protein
H9L23_RS02975	COG1136	(ABC) transporter
H9L23_RS03000	COG0735	belongs to the Fur family
H9L23_RS03045	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H9L23_RS03090	COG1349	DNA-binding transcription factor activity
H9L23_RS03115	COG0205	6-phosphofructokinase activity
H9L23_RS03135	COG0439	Biotin carboxylase
H9L23_RS03175	COG1764	response to oxidative stress
H9L23_RS03180	COG1846	Transcriptional regulator
H9L23_RS03195	COG2824	Alkylphosphonate utilization operon protein PhnA
H9L23_RS03200	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H9L23_RS03210	COG2197	response regulator
H9L23_RS03240	COG0629	single-stranded DNA binding
H9L23_RS03300	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H9L23_RS03335	COG0360	Binds together with S18 to 16S ribosomal RNA
H9L23_RS03340	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H9L23_RS03345	COG0359	binds to the 23S rRNA
H9L23_RS03355	COG1028	Short-chain dehydrogenase reductase Sdr
H9L23_RS03370	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H9L23_RS03405	COG0247	lactate metabolic process
H9L23_RS03405	COG2181	nitrate reductase activity
H9L23_RS03410	COG0247	lactate metabolic process
H9L23_RS03410	COG2181	nitrate reductase activity
H9L23_RS03425	COG1396	sequence-specific DNA binding
H9L23_RS03435	COG3550	peptidyl-serine autophosphorylation
H9L23_RS03470	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H9L23_RS03485	COG1629	transport
H9L23_RS03495	COG1785	Belongs to the alkaline phosphatase family
H9L23_RS03515	COG3275	phosphorelay sensor kinase activity
H9L23_RS03520	COG3279	Response regulator of the LytR AlgR family
H9L23_RS03540	COG3347	Dehydrogenase
H9L23_RS03540	COG1028	Short-chain dehydrogenase reductase Sdr
H9L23_RS03545	COG4952	isomerase
H9L23_RS03570	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H9L23_RS03575	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H9L23_RS03580	COG1435	thymidine kinase activity
H9L23_RS03590	COG0772	Belongs to the SEDS family
H9L23_RS03595	COG0768	penicillin binding
H9L23_RS03610	COG1077	Cell shape determining protein MreB Mrl
H9L23_RS03615	COG0138	bifunctional purine biosynthesis protein purh
H9L23_RS03625	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H9L23_RS03630	COG0268	Binds directly to 16S ribosomal RNA
H9L23_RS03635	COG2003	Belongs to the UPF0758 family
H9L23_RS03675	COG1418	mRNA catabolic process
H9L23_RS03730	COG1960	acyl-CoA dehydrogenase activity
H9L23_RS03745	COG0828	Belongs to the bacterial ribosomal protein bS21 family
H9L23_RS03750	COG4974	Belongs to the 'phage' integrase family
H9L23_RS03805	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H9L23_RS03810	COG0081	regulation of translation
H9L23_RS03815	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H9L23_RS03820	COG0222	ribosome binding
H9L23_RS03825	COG0085	RNA polymerase activity
H9L23_RS03830	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H9L23_RS03870	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H9L23_RS03885	COG0009	L-threonylcarbamoyladenylate synthase
H9L23_RS03905	COG2171	N-acyltransferase activity
H9L23_RS03920	COG3118	belongs to the thioredoxin family
H9L23_RS03925	COG0590	tRNA wobble adenosine to inosine editing
H9L23_RS03935	COG0187	DNA topoisomerase II activity
H9L23_RS03940	COG1695	Transcriptional regulator
H9L23_RS03960	COG3781	membrane
H9L23_RS03970	COG5002	protein histidine kinase activity
H9L23_RS03975	COG0745	RESPONSE REGULATOR receiver
H9L23_RS04020	COG3118	belongs to the thioredoxin family
H9L23_RS04025	COG2133	pyrroloquinoline quinone binding
H9L23_RS04040	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H9L23_RS04040	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H9L23_RS04050	COG0028	Belongs to the TPP enzyme family
H9L23_RS04060	COG3185	4-Hydroxyphenylpyruvate dioxygenase
H9L23_RS04075	COG0179	Fumarylacetoacetate (FAA) hydrolase
H9L23_RS04120	COG1028	Short-chain dehydrogenase reductase Sdr
H9L23_RS04140	COG0423	glycine-tRNA ligase activity
H9L23_RS04165	COG4585	Histidine kinase
H9L23_RS04170	COG2197	response regulator
H9L23_RS04225	COG0586	Pfam SNARE associated Golgi protein
H9L23_RS04250	COG2234	aminopeptidase activity
H9L23_RS04255	COG0443	Heat shock 70 kDa protein
H9L23_RS04260	COG1629	transport
H9L23_RS04260	COG4206	TonB-dependent receptor
H9L23_RS04280	COG4115	mRNA cleavage
H9L23_RS04290	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H9L23_RS04295	COG0513	Belongs to the DEAD box helicase family
H9L23_RS04325	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H9L23_RS04345	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H9L23_RS04380	COG0633	Ferredoxin
H9L23_RS04405	COG0424	maF-like protein
H9L23_RS04415	COG0248	Ppx GppA phosphatase
H9L23_RS04435	COG0484	heat shock protein binding
H9L23_RS04440	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H9L23_RS04445	COG2884	Cell division ATP-binding protein ftsE
H9L23_RS04465	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H9L23_RS04510	COG0140	phosphoribosyl-ATP diphosphatase activity
H9L23_RS04510	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H9L23_RS04515	COG0107	imidazoleglycerol-phosphate synthase activity
H9L23_RS04520	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H9L23_RS04525	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H9L23_RS04535	COG0131	Imidazoleglycerol-phosphate dehydratase
H9L23_RS04535	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H9L23_RS04540	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H9L23_RS04550	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H9L23_RS04555	COG2989	Protein conserved in bacteria
H9L23_RS04560	COG2310	stress, protein
H9L23_RS04575	COG2310	stress, protein
H9L23_RS04600	COG4245	von Willebrand factor, type A
H9L23_RS04620	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H9L23_RS04640	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
H9L23_RS04690	COG0463	Glycosyl transferase, family 2
H9L23_RS04715	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
H9L23_RS04720	COG0750	zinc metalloprotease
H9L23_RS04725	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
H9L23_RS04730	COG2814	Major facilitator Superfamily
H9L23_RS04740	COG3239	Fatty acid desaturase
H9L23_RS04780	COG0402	S-adenosylhomocysteine deaminase activity
H9L23_RS04850	COG0714	Associated with various cellular activities
H9L23_RS04880	COG1522	sequence-specific DNA binding
H9L23_RS04885	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
H9L23_RS04910	COG4529	Protein conserved in bacteria
H9L23_RS04920	COG0702	epimerase
H9L23_RS04935	COG4771	TonB-dependent receptor
H9L23_RS04970	COG3250	beta-galactosidase activity
H9L23_RS04975	COG3345	alpha-galactosidase
H9L23_RS05000	COG3486	L-lysine 6-monooxygenase (NADPH) activity
H9L23_RS05010	COG0076	glutamate decarboxylase activity
H9L23_RS05025	COG1959	2 iron, 2 sulfur cluster binding
H9L23_RS05030	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H9L23_RS05035	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H9L23_RS05035	COG1648	precorrin-2 dehydrogenase activity
H9L23_RS05040	COG0730	response to heat
H9L23_RS05045	COG0175	sulfate reduction
H9L23_RS05055	COG2895	sulfate adenylyltransferase (ATP) activity
H9L23_RS05070	COG0297	glycogen (starch) synthase activity
H9L23_RS05075	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H9L23_RS05080	COG3387	PFAM Glycoside hydrolase 15-related
H9L23_RS05085	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
H9L23_RS05090	COG4191	Histidine kinase
H9L23_RS05095	COG2204	response regulator
H9L23_RS05105	COG1136	(ABC) transporter
H9L23_RS05115	COG0577	efflux transmembrane transporter activity
H9L23_RS05115	COG1136	(ABC) transporter
H9L23_RS05125	COG0577	efflux transmembrane transporter activity
H9L23_RS05130	COG1136	(ABC) transporter
H9L23_RS05130	COG0577	efflux transmembrane transporter activity
H9L23_RS05135	COG0577	efflux transmembrane transporter activity
H9L23_RS05140	COG1136	(ABC) transporter
H9L23_RS05140	COG0577	efflux transmembrane transporter activity
H9L23_RS05150	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H9L23_RS05170	COG0544	peptidyl-prolyl cis-trans isomerase activity
H9L23_RS05185	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H9L23_RS05190	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H9L23_RS05195	COG1132	(ABC) transporter
H9L23_RS05200	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H9L23_RS05220	COG3655	Transcriptional regulator
H9L23_RS05225	COG0045	succinate-CoA ligase (ADP-forming) activity
H9L23_RS05255	COG1136	(ABC) transporter
H9L23_RS05280	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H9L23_RS05280	COG0758	DNA mediated transformation
H9L23_RS05295	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H9L23_RS05320	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
H9L23_RS05320	COG1796	DNA polymerase
H9L23_RS05330	COG0616	signal peptide processing
H9L23_RS05345	COG1183	phosphatidylcholine synthase activity
H9L23_RS05350	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
H9L23_RS05355	COG0284	orotidine-5'-phosphate decarboxylase activity
H9L23_RS05380	COG1674	ftsk spoiiie
H9L23_RS05395	COG0321	lipoyl(octanoyl) transferase activity
H9L23_RS05395	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
H9L23_RS05460	COG0583	DNA-binding transcription factor activity
H9L23_RS05520	COG4977	sequence-specific DNA binding
H9L23_RS05520	COG1917	Cupin 2, conserved barrel domain protein
H9L23_RS05525	COG0300	oxidoreductase activity
H9L23_RS05560	COG2205	protein histidine kinase activity
H9L23_RS05575	COG1028	Short-chain dehydrogenase reductase Sdr
H9L23_RS05580	COG2721	sulfolactate sulfo-lyase activity
H9L23_RS05585	COG0738	Major facilitator superfamily
H9L23_RS05595	COG4977	sequence-specific DNA binding
H9L23_RS05635	COG0861	Integral membrane protein TerC family
H9L23_RS05650	COG2310	stress, protein
H9L23_RS05655	COG2310	stress, protein
H9L23_RS05660	COG3853	Toxic anion resistance protein (TelA)
H9L23_RS05680	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H9L23_RS05690	COG3279	Response regulator of the LytR AlgR family
H9L23_RS05700	COG1131	(ABC) transporter
H9L23_RS05745	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H9L23_RS05755	COG0628	permease
H9L23_RS05765	COG0745	RESPONSE REGULATOR receiver
H9L23_RS05775	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H9L23_RS05780	COG2186	Transcriptional regulator
H9L23_RS05785	COG4771	TonB-dependent receptor
H9L23_RS05790	COG0702	epimerase
H9L23_RS05795	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H9L23_RS05805	COG2271	Major facilitator Superfamily
H9L23_RS05835	COG0583	DNA-binding transcription factor activity
H9L23_RS05885	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H9L23_RS05910	COG1611	Belongs to the LOG family
H9L23_RS05920	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H9L23_RS05925	COG1028	Short-chain dehydrogenase reductase Sdr
H9L23_RS05940	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H9L23_RS05945	COG0135	phosphoribosylanthranilate isomerase activity
H9L23_RS05950	COG0133	tryptophan synthase activity
H9L23_RS05955	COG0159	tryptophan synthase activity
H9L23_RS05970	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H9L23_RS06025	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
H9L23_RS06035	COG3586	endonuclease activity
H9L23_RS06045	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H9L23_RS06060	COG0009	L-threonylcarbamoyladenylate synthase
H9L23_RS06065	COG2161	toxin-antitoxin pair type II binding
H9L23_RS06070	COG4115	mRNA cleavage
H9L23_RS06080	COG0017	Asparaginyl-tRNA synthetase
H9L23_RS06085	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H9L23_RS06100	COG2308	Evidence 4 Homologs of previously reported genes of
H9L23_RS06105	COG1528	Iron-storage protein
H9L23_RS06115	COG0456	acetyltransferase
H9L23_RS06120	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H9L23_RS06125	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H9L23_RS06140	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H9L23_RS06165	COG0346	lactoylglutathione lyase activity
H9L23_RS06175	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
H9L23_RS06195	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
H9L23_RS06200	COG0328	RNA-DNA hybrid ribonuclease activity
H9L23_RS06215	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H9L23_RS06215	COG1648	precorrin-2 dehydrogenase activity
H9L23_RS06220	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H9L23_RS06225	COG2146	nitrite reductase [NAD(P)H] activity
H9L23_RS06225	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H9L23_RS06235	COG2223	nitrite transmembrane transporter activity
H9L23_RS06240	COG0243	molybdopterin cofactor binding
H9L23_RS06255	COG0746	molybdenum cofactor guanylyltransferase activity
H9L23_RS06280	COG4771	TonB-dependent receptor
H9L23_RS06285	COG0702	epimerase
H9L23_RS06300	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H9L23_RS06310	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H9L23_RS06315	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H9L23_RS06335	COG1629	transport
H9L23_RS06340	COG0702	epimerase
H9L23_RS06385	COG2205	protein histidine kinase activity
H9L23_RS06415	COG1595	DNA-templated transcription, initiation
H9L23_RS06425	COG4771	TonB-dependent receptor
H9L23_RS06435	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H9L23_RS06440	COG0793	Belongs to the peptidase S41A family
H9L23_RS06445	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H9L23_RS06450	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H9L23_RS06455	COG2205	protein histidine kinase activity
H9L23_RS06500	COG0387	Pfam Sodium calcium exchanger
H9L23_RS06515	COG2885	chlorophyll binding
H9L23_RS06520	COG4565	transcriptional regulatory protein
H9L23_RS06540	COG4206	TonB-dependent receptor
H9L23_RS06540	COG1629	transport
H9L23_RS06555	COG3525	Glycosyl hydrolase, family 20, catalytic domain
H9L23_RS06560	COG2610	gluconate transmembrane transporter activity
H9L23_RS06610	COG1673	EVE domain
H9L23_RS06630	COG0488	(ABC) transporter
H9L23_RS06645	COG0697	spore germination
H9L23_RS06650	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H9L23_RS06665	COG5002	protein histidine kinase activity
H9L23_RS06670	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H9L23_RS06675	COG1063	alcohol dehydrogenase
H9L23_RS06700	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H9L23_RS06700	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H9L23_RS06735	COG2205	protein histidine kinase activity
H9L23_RS06740	COG0745	RESPONSE REGULATOR receiver
H9L23_RS06760	COG0306	phosphate transporter
H9L23_RS06800	COG2132	Multicopper oxidase
H9L23_RS06830	COG1063	alcohol dehydrogenase
H9L23_RS06835	COG5002	protein histidine kinase activity
H9L23_RS06855	COG1621	beta-fructofuranosidase activity
H9L23_RS06890	COG0006	proline dipeptidase activity
H9L23_RS06895	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H9L23_RS06905	COG3938	Belongs to the proline racemase family
H9L23_RS06910	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H9L23_RS06925	COG0531	amino acid
H9L23_RS06950	COG0745	RESPONSE REGULATOR receiver
H9L23_RS06950	COG3292	Two component regulator propeller
H9L23_RS06950	COG2205	protein histidine kinase activity
H9L23_RS06955	COG1629	transport
H9L23_RS06960	COG0702	epimerase
H9L23_RS06990	COG0577	efflux transmembrane transporter activity
H9L23_RS07015	COG1368	sulfuric ester hydrolase activity
H9L23_RS07025	COG3179	chitinase
H9L23_RS07070	COG0673	inositol 2-dehydrogenase activity
H9L23_RS07095	COG4221	oxidoreductase activity
H9L23_RS07115	COG4251	negative regulation of phosphorylation
H9L23_RS07140	COG3387	PFAM Glycoside hydrolase 15-related
H9L23_RS07150	COG1085	galactose-1-phosphate uridylyltransferase
H9L23_RS07155	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
H9L23_RS07165	COG0025	NhaP-type Na H and K H
H9L23_RS07185	COG1360	Flagellar Motor Protein
H9L23_RS07215	COG0163	prenyltransferase activity
H9L23_RS07220	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H9L23_RS07230	COG0483	inositol monophosphate 1-phosphatase activity
H9L23_RS07235	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
H9L23_RS07270	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H9L23_RS07275	COG0450	alkyl hydroperoxide reductase
H9L23_RS07290	COG0527	aspartate kinase activity
H9L23_RS07295	COG1247	-acetyltransferase
H9L23_RS07300	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H9L23_RS07310	COG1193	negative regulation of DNA recombination
H9L23_RS07315	COG2133	pyrroloquinoline quinone binding
H9L23_RS07320	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H9L23_RS07330	COG0572	uridine kinase
H9L23_RS07335	COG0791	NLP P60 protein
H9L23_RS07335	COG1388	LysM domain
H9L23_RS07340	COG0783	Belongs to the Dps family
H9L23_RS07375	COG3851	Histidine kinase
H9L23_RS07380	COG2197	response regulator
H9L23_RS07400	COG0442	prolyl-tRNA aminoacylation
H9L23_RS07405	COG0626	cystathionine gamma-synthase activity
H9L23_RS07430	COG2197	response regulator
H9L23_RS07450	COG2885	chlorophyll binding
H9L23_RS07455	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H9L23_RS07460	COG0587	DNA-directed DNA polymerase activity
H9L23_RS07470	COG0463	Glycosyl transferase, family 2
H9L23_RS07475	COG3104	oligopeptide transport
H9L23_RS07480	COG3104	oligopeptide transport
H9L23_RS07485	COG3104	oligopeptide transport
H9L23_RS07495	COG0183	Belongs to the thiolase family
H9L23_RS07515	COG1480	7TM receptor with intracellular HD hydrolase
H9L23_RS07535	COG4974	Belongs to the 'phage' integrase family
H9L23_RS07610	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H9L23_RS07680	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H9L23_RS07690	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H9L23_RS07705	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
H9L23_RS07710	COG1216	Glycosyl transferase, family 2
H9L23_RS07735	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
H9L23_RS07745	COG0726	polysaccharide deacetylase
H9L23_RS07750	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H9L23_RS07765	COG0529	Catalyzes the synthesis of activated sulfate
H9L23_RS07770	COG1396	sequence-specific DNA binding
H9L23_RS07770	COG3800	Transcriptional regulator
H9L23_RS07870	COG2801	Transposase and inactivated derivatives
H9L23_RS07910	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
H9L23_RS07935	COG3046	protein related to deoxyribodipyrimidine photolyase
H9L23_RS07940	COG0415	Belongs to the DNA photolyase family
H9L23_RS07960	COG1028	Short-chain dehydrogenase reductase Sdr
H9L23_RS07975	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
H9L23_RS07980	COG2205	protein histidine kinase activity
H9L23_RS07985	COG5002	protein histidine kinase activity
H9L23_RS08000	COG0513	Belongs to the DEAD box helicase family
H9L23_RS08010	COG1127	ABC transporter
H9L23_RS08015	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H9L23_RS08020	COG0702	epimerase
H9L23_RS08025	COG4771	TonB-dependent receptor
H9L23_RS08035	COG0745	RESPONSE REGULATOR receiver
H9L23_RS08040	COG5002	protein histidine kinase activity
H9L23_RS08045	COG0671	phosphoesterase, PA-phosphatase related
H9L23_RS08060	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H9L23_RS08075	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H9L23_RS08155	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H9L23_RS08170	COG0667	Aldo Keto reductase
H9L23_RS08175	COG0346	lactoylglutathione lyase activity
H9L23_RS08230	COG5002	protein histidine kinase activity
H9L23_RS08235	COG1012	belongs to the aldehyde dehydrogenase family
H9L23_RS08250	COG0667	Aldo Keto reductase
H9L23_RS08260	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H9L23_RS08300	COG4953	penicillin-binding protein 1C
H9L23_RS08310	COG2373	Large extracellular alpha-helical protein
H9L23_RS08325	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H9L23_RS08325	COG1754	DNA topoisomerase type I activity
H9L23_RS08330	COG0386	Belongs to the glutathione peroxidase family
H9L23_RS08335	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
H9L23_RS08350	COG1609	Transcriptional regulator
H9L23_RS08360	COG1629	transport
H9L23_RS08370	COG1629	transport
H9L23_RS08375	COG0702	epimerase
H9L23_RS08380	COG3250	beta-galactosidase activity
H9L23_RS08390	COG3250	beta-galactosidase activity
H9L23_RS08400	COG3250	beta-galactosidase activity
H9L23_RS08410	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
H9L23_RS08420	COG1028	Short-chain dehydrogenase reductase Sdr
H9L23_RS08425	COG1312	Catalyzes the dehydration of D-mannonate
H9L23_RS08440	COG0726	polysaccharide deacetylase
H9L23_RS08445	COG2249	NAD(P)H dehydrogenase (quinone) activity
H9L23_RS08450	COG1733	regulation of RNA biosynthetic process
H9L23_RS08465	COG1640	4-alpha-glucanotransferase
H9L23_RS08475	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
H9L23_RS08500	COG0577	efflux transmembrane transporter activity
H9L23_RS08505	COG4771	TonB-dependent receptor
H9L23_RS08520	COG0700	Nucleoside recognition
H9L23_RS08525	COG0823	Involved in the tonB-independent uptake of proteins
H9L23_RS08525	COG1506	peptidase
H9L23_RS08530	COG0706	membrane insertase activity
H9L23_RS08535	COG0504	CTP synthase activity
H9L23_RS08570	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
H9L23_RS08575	COG1428	Deoxynucleoside kinase
H9L23_RS08580	COG0180	Tryptophanyl-tRNA synthetase
H9L23_RS08590	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H9L23_RS08595	COG1136	(ABC) transporter
H9L23_RS08615	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H9L23_RS08620	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H9L23_RS08625	COG1136	(ABC) transporter
H9L23_RS08625	COG0577	efflux transmembrane transporter activity
H9L23_RS08645	COG0363	glucosamine-6-phosphate deaminase activity
H9L23_RS08650	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H9L23_RS08655	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
H9L23_RS08680	COG1629	transport
H9L23_RS08700	COG0584	glycerophosphoryl diester phosphodiesterase
H9L23_RS08720	COG1666	GTP binding
H9L23_RS08730	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
H9L23_RS08740	COG0436	Aminotransferase
H9L23_RS08755	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H9L23_RS08770	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H9L23_RS08770	COG1199	ATP-dependent helicase activity
H9L23_RS08780	COG0745	RESPONSE REGULATOR receiver
H9L23_RS08785	COG3279	Response regulator of the LytR AlgR family
H9L23_RS08795	COG3279	Response regulator of the LytR AlgR family
H9L23_RS08820	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
H9L23_RS08855	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
H9L23_RS08880	COG0702	epimerase
H9L23_RS08910	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
H9L23_RS08915	COG0156	8-amino-7-oxononanoate synthase activity
H9L23_RS08920	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H9L23_RS08940	COG0823	Involved in the tonB-independent uptake of proteins
H9L23_RS08950	COG2326	polyphosphate kinase activity
H9L23_RS08975	COG1999	signal sequence binding
H9L23_RS08995	COG1858	cytochrome C peroxidase
H9L23_RS09025	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H9L23_RS09030	COG0527	aspartate kinase activity
H9L23_RS09040	COG0019	diaminopimelate decarboxylase activity
H9L23_RS09060	COG1960	acyl-CoA dehydrogenase activity
H9L23_RS09070	COG0277	FAD linked oxidase domain protein
H9L23_RS09100	COG3279	Response regulator of the LytR AlgR family
H9L23_RS09105	COG3275	phosphorelay sensor kinase activity
H9L23_RS09110	COG1136	(ABC) transporter
H9L23_RS09110	COG0577	efflux transmembrane transporter activity
H9L23_RS09115	COG1136	(ABC) transporter
H9L23_RS09130	COG2814	Major facilitator Superfamily
H9L23_RS09135	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
H9L23_RS09160	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H9L23_RS09185	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
H9L23_RS09195	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
H9L23_RS09215	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H9L23_RS09220	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H9L23_RS09230	COG1349	DNA-binding transcription factor activity
H9L23_RS09235	COG0745	RESPONSE REGULATOR receiver
H9L23_RS09280	COG0745	RESPONSE REGULATOR receiver
H9L23_RS09285	COG5002	protein histidine kinase activity
H9L23_RS09300	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H9L23_RS09345	COG4191	Histidine kinase
H9L23_RS09355	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H9L23_RS09360	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H9L23_RS09375	COG3278	Belongs to the heme-copper respiratory oxidase family
H9L23_RS09430	COG0489	protein tyrosine kinase activity
H9L23_RS09430	COG3206	protein involved in exopolysaccharide biosynthesis
H9L23_RS09440	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
H9L23_RS09455	COG2244	polysaccharide biosynthetic process
H9L23_RS09485	COG0367	asparagine synthase
H9L23_RS09505	COG0438	transferase activity, transferring glycosyl groups
H9L23_RS09510	COG1215	transferase activity, transferring glycosyl groups
H9L23_RS09520	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H9L23_RS09535	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H9L23_RS09550	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H9L23_RS09560	COG2197	response regulator
H9L23_RS09570	COG1295	ribonuclease BN
H9L23_RS09590	COG1181	Belongs to the D-alanine--D-alanine ligase family
H9L23_RS09600	COG3142	Participates in the control of copper homeostasis
H9L23_RS09610	COG1446	asparaginase
H9L23_RS09620	COG0436	Aminotransferase
H9L23_RS09625	COG1477	protein flavinylation
H9L23_RS09635	COG1619	proteins homologs of microcin C7 resistance protein MccF
H9L23_RS09650	COG2885	chlorophyll binding
H9L23_RS09660	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H9L23_RS09670	COG2017	converts alpha-aldose to the beta-anomer
H9L23_RS09680	COG0813	purine-nucleoside phosphorylase activity
H9L23_RS09685	COG1739	Uncharacterized protein family UPF0029
H9L23_RS09690	COG0697	spore germination
H9L23_RS09695	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H9L23_RS09695	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H9L23_RS09700	COG2890	protein-(glutamine-N5) methyltransferase activity
H9L23_RS09710	COG4974	Belongs to the 'phage' integrase family
H9L23_RS09715	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H9L23_RS09720	COG1216	Glycosyl transferase, family 2
H9L23_RS09735	COG0598	Magnesium transport protein CorA
H9L23_RS09740	COG3609	addiction module antidote protein, CC2985 family
H9L23_RS09750	COG2239	Acts as a magnesium transporter
H9L23_RS09755	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H9L23_RS09760	COG1764	response to oxidative stress
H9L23_RS09785	COG5002	protein histidine kinase activity
H9L23_RS09795	COG0438	transferase activity, transferring glycosyl groups
H9L23_RS09800	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
H9L23_RS09820	COG0668	transmembrane transport
H9L23_RS09825	COG0745	RESPONSE REGULATOR receiver
H9L23_RS09830	COG4251	negative regulation of phosphorylation
H9L23_RS09835	COG2197	response regulator
H9L23_RS09855	COG4771	TonB-dependent receptor
H9L23_RS09865	COG1609	Transcriptional regulator
H9L23_RS09870	COG1595	DNA-templated transcription, initiation
H9L23_RS09880	COG4206	TonB-dependent receptor
H9L23_RS09880	COG1629	transport
H9L23_RS09905	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H9L23_RS09935	COG2211	Major facilitator Superfamily
H9L23_RS09945	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
H9L23_RS09950	COG2086	electron transfer activity
H9L23_RS09970	COG0305	Participates in initiation and elongation during chromosome replication
H9L23_RS09975	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H9L23_RS09985	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H9L23_RS09985	COG0517	IMP dehydrogenase activity
H9L23_RS09990	COG0514	ATP-dependent DNA helicase (RecQ)
H9L23_RS09995	COG2877	3-deoxy-8-phosphooctulonate synthase activity
H9L23_RS10010	COG0602	queuosine metabolic process
H9L23_RS10020	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H9L23_RS10025	COG0481	GTPase activity
H9L23_RS10035	COG0366	Alpha amylase catalytic
H9L23_RS10085	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H9L23_RS10095	COG1304	FMN binding
H9L23_RS10105	COG3254	rhamnose metabolic process
H9L23_RS10110	COG0179	Fumarylacetoacetate (FAA) hydrolase
H9L23_RS10115	COG1028	Short-chain dehydrogenase reductase Sdr
H9L23_RS10145	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H9L23_RS10150	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H9L23_RS10155	COG2169	Transcriptional regulator
H9L23_RS10165	COG4771	TonB-dependent receptor
H9L23_RS10180	COG4771	TonB-dependent receptor
H9L23_RS10185	COG0702	epimerase
H9L23_RS10225	COG3250	beta-galactosidase activity
H9L23_RS10230	COG3250	beta-galactosidase activity
H9L23_RS10260	COG0673	inositol 2-dehydrogenase activity
H9L23_RS10280	COG3408	Glycogen debranching enzyme
H9L23_RS10290	COG3250	beta-galactosidase activity
H9L23_RS10305	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H9L23_RS10315	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H9L23_RS10320	COG1607	acyl-coa hydrolase
H9L23_RS10325	COG0738	Major facilitator superfamily
H9L23_RS10330	COG3940	Belongs to the glycosyl hydrolase 43 family
H9L23_RS10350	COG1028	Short-chain dehydrogenase reductase Sdr
H9L23_RS10355	COG1063	alcohol dehydrogenase
H9L23_RS10370	COG2160	L-arabinose isomerase activity
H9L23_RS10405	COG1028	Short-chain dehydrogenase reductase Sdr
H9L23_RS10425	COG1917	Cupin 2, conserved barrel domain protein
H9L23_RS10425	COG4977	sequence-specific DNA binding
H9L23_RS10435	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H9L23_RS10465	COG1132	(ABC) transporter
H9L23_RS10490	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H9L23_RS10500	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H9L23_RS10505	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H9L23_RS10515	COG0070	glutamate synthase
H9L23_RS10515	COG0069	glutamate synthase activity
H9L23_RS10515	COG0067	glutamate synthase
H9L23_RS10525	COG1289	transmembrane transporter activity
H9L23_RS10530	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
H9L23_RS10540	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H9L23_RS10560	COG2842	Transposition protein
H9L23_RS10570	COG1395	domain, Protein
H9L23_RS10675	COG1515	deoxyribonuclease V activity
H9L23_RS10690	COG0408	coproporphyrinogen oxidase activity
H9L23_RS10695	COG2814	Major facilitator Superfamily
H9L23_RS10720	COG0534	Mate efflux family protein
H9L23_RS10735	COG0564	pseudouridine synthase activity
H9L23_RS10740	COG0123	including yeast histone deacetylase and acetoin utilization protein
H9L23_RS10745	COG3781	membrane
H9L23_RS10750	COG3844	kynureninase activity
H9L23_RS10760	COG2094	Belongs to the DNA glycosylase MPG family
H9L23_RS10765	COG1956	GAF domain-containing protein
H9L23_RS10815	COG4206	TonB-dependent receptor
H9L23_RS10865	COG0564	pseudouridine synthase activity
H9L23_RS10870	COG0745	RESPONSE REGULATOR receiver
H9L23_RS10875	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H9L23_RS10880	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H9L23_RS10905	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H9L23_RS10920	COG0658	competence protein
H9L23_RS10920	COG2333	competence protein COMEC
H9L23_RS10925	COG1024	Enoyl-CoA hydratase
H9L23_RS10935	COG0823	Involved in the tonB-independent uptake of proteins
H9L23_RS10935	COG1506	peptidase
H9L23_RS10955	COG1793	dna ligase
H9L23_RS10960	COG1201	RNA secondary structure unwinding
H9L23_RS10970	COG3118	belongs to the thioredoxin family
H9L23_RS10980	COG0508	dehydrogenase complex catalyzes the overall conversion of
H9L23_RS10985	COG1546	Belongs to the CinA family
H9L23_RS10985	COG1058	Belongs to the CinA family
H9L23_RS10995	COG0860	N-Acetylmuramoyl-L-alanine amidase
H9L23_RS11000	COG1388	LysM domain
H9L23_RS11000	COG0860	N-Acetylmuramoyl-L-alanine amidase
H9L23_RS11010	COG1234	tRNA 3'-trailer cleavage
H9L23_RS11020	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H9L23_RS11030	COG1702	phosphate starvation-inducible protein PhoH
H9L23_RS11045	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H9L23_RS11050	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
H9L23_RS11060	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H9L23_RS11075	COG1185	polyribonucleotide nucleotidyltransferase activity
H9L23_RS11080	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H9L23_RS11095	COG0824	Thioesterase
H9L23_RS11115	COG1629	transport
H9L23_RS11140	COG0024	Methionine aminopeptidase
H9L23_RS11150	COG2207	Transcriptional regulator
H9L23_RS11185	COG4206	TonB-dependent receptor
H9L23_RS11185	COG1629	transport
H9L23_RS11240	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H9L23_RS11245	COG0791	NLP P60 protein
H9L23_RS11265	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
H9L23_RS11270	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H9L23_RS11275	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H9L23_RS11280	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H9L23_RS11290	COG2755	lipolytic protein G-D-S-L family
H9L23_RS11290	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H9L23_RS11305	COG2270	Major facilitator Superfamily
H9L23_RS11310	COG0514	ATP-dependent DNA helicase (RecQ)
H9L23_RS11315	COG4804	nuclease activity
H9L23_RS11320	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H9L23_RS11350	COG2081	HI0933 family
H9L23_RS11355	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H9L23_RS11360	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
H9L23_RS11365	COG1678	Uncharacterized ACR, COG1678
H9L23_RS11385	COG1629	transport
H9L23_RS11385	COG4206	TonB-dependent receptor
H9L23_RS11390	COG1250	3-hydroxyacyl-CoA dehydrogenase
H9L23_RS11395	COG2255	four-way junction helicase activity
H9L23_RS11400	COG3153	acetyltransferase
H9L23_RS11400	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H9L23_RS11410	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H9L23_RS11415	COG1064	alcohol dehydrogenase
H9L23_RS11420	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H9L23_RS11425	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
H9L23_RS11430	COG2080	2 iron, 2 sulfur cluster binding
H9L23_RS11435	COG3132	Protein of unknown function, DUF480
H9L23_RS11440	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H9L23_RS11445	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
H9L23_RS11465	COG0300	oxidoreductase activity
H9L23_RS11470	COG1028	Short-chain dehydrogenase reductase Sdr
H9L23_RS11475	COG0798	PFAM Bile acid sodium symporter
H9L23_RS11480	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H9L23_RS11505	COG3537	Alpha-1,2-mannosidase
H9L23_RS11510	COG0482	sulfurtransferase activity
H9L23_RS11520	COG0745	RESPONSE REGULATOR receiver
H9L23_RS11525	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H9L23_RS11530	COG4948	Mandelate Racemase Muconate Lactonizing
H9L23_RS11545	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H9L23_RS11550	COG1028	Short-chain dehydrogenase reductase Sdr
H9L23_RS11585	COG4771	TonB-dependent receptor
H9L23_RS11615	COG0280	phosphate acetyltransferase
H9L23_RS11615	COG0857	belongs to the CobB CobQ family
H9L23_RS11620	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H9L23_RS11640	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
H9L23_RS11645	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H9L23_RS11650	COG1174	glycine betaine transport
H9L23_RS11655	COG0517	IMP dehydrogenase activity
H9L23_RS11655	COG1125	glycine betaine transport
H9L23_RS11660	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H9L23_RS11670	COG1914	H( )-stimulated, divalent metal cation uptake system
H9L23_RS11675	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
H9L23_RS11690	COG4251	negative regulation of phosphorylation
H9L23_RS11715	COG0702	epimerase
H9L23_RS11720	COG4206	TonB-dependent receptor
H9L23_RS11720	COG1629	transport
H9L23_RS11745	COG0025	NhaP-type Na H and K H
H9L23_RS11770	COG1045	serine acetyltransferase
H9L23_RS11790	COG3239	Fatty acid desaturase
H9L23_RS11850	COG3179	chitinase
H9L23_RS11860	COG3250	beta-galactosidase activity
H9L23_RS11895	COG4771	TonB-dependent receptor
H9L23_RS11905	COG1629	transport
H9L23_RS11905	COG4206	TonB-dependent receptor
H9L23_RS11915	COG2205	protein histidine kinase activity
H9L23_RS11915	COG3292	Two component regulator propeller
H9L23_RS11915	COG0745	RESPONSE REGULATOR receiver
H9L23_RS11940	COG0702	epimerase
H9L23_RS11945	COG1629	transport
H9L23_RS11950	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H9L23_RS11970	COG4771	TonB-dependent receptor
H9L23_RS11985	COG3279	Response regulator of the LytR AlgR family
H9L23_RS12020	COG0693	protein deglycase activity
H9L23_RS12020	COG0753	catalase activity
H9L23_RS12025	COG3685	Protein conserved in bacteria
H9L23_RS12030	COG1733	regulation of RNA biosynthetic process
H9L23_RS12035	COG1028	Short-chain dehydrogenase reductase Sdr
H9L23_RS12080	COG5002	protein histidine kinase activity
H9L23_RS12100	COG0392	lysyltransferase activity
H9L23_RS12100	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
H9L23_RS12115	COG0300	oxidoreductase activity
H9L23_RS12135	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
H9L23_RS12175	COG1312	Catalyzes the dehydration of D-mannonate
H9L23_RS12210	COG4206	TonB-dependent receptor
H9L23_RS12210	COG1629	transport
H9L23_RS12215	COG0702	epimerase
H9L23_RS12250	COG3250	beta-galactosidase activity
H9L23_RS12255	COG0702	epimerase
H9L23_RS12260	COG4771	TonB-dependent receptor
H9L23_RS12265	COG3507	Belongs to the glycosyl hydrolase 43 family
H9L23_RS12290	COG1629	transport
H9L23_RS12300	COG3940	Belongs to the glycosyl hydrolase 43 family
H9L23_RS12315	COG1472	Belongs to the glycosyl hydrolase 3 family
H9L23_RS12320	COG3250	beta-galactosidase activity
H9L23_RS12325	COG3250	beta-galactosidase activity
H9L23_RS12325	COG3250	beta-galactosidase activity
H9L23_RS12335	COG3534	alpha-L-arabinofuranosidase
H9L23_RS12345	COG0561	phosphatase activity
H9L23_RS12350	COG4771	TonB-dependent receptor
H9L23_RS12355	COG1501	Belongs to the glycosyl hydrolase 31 family
H9L23_RS12360	COG2205	protein histidine kinase activity
H9L23_RS12360	COG3292	Two component regulator propeller
H9L23_RS12360	COG0745	RESPONSE REGULATOR receiver
H9L23_RS12365	COG3408	Glycogen debranching enzyme
H9L23_RS12385	COG0702	epimerase
H9L23_RS12390	COG4771	TonB-dependent receptor
H9L23_RS12395	COG2340	Cysteine-rich secretory protein family
H9L23_RS12425	COG1733	regulation of RNA biosynthetic process
H9L23_RS12430	COG0778	Nitroreductase
H9L23_RS12445	COG1028	Short-chain dehydrogenase reductase Sdr
H9L23_RS12450	COG1595	DNA-templated transcription, initiation
H9L23_RS12460	COG2080	2 iron, 2 sulfur cluster binding
H9L23_RS12465	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
H9L23_RS12470	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H9L23_RS12485	COG0745	RESPONSE REGULATOR receiver
H9L23_RS12520	COG4977	sequence-specific DNA binding
H9L23_RS12520	COG1917	Cupin 2, conserved barrel domain protein
H9L23_RS12525	COG4221	oxidoreductase activity
H9L23_RS12530	COG0667	Aldo Keto reductase
H9L23_RS12545	COG1316	TRANSCRIPTIONal
H9L23_RS12555	COG0463	Glycosyl transferase, family 2
H9L23_RS12580	COG1216	Glycosyl transferase, family 2
H9L23_RS12585	COG0463	Glycosyl transferase, family 2
H9L23_RS12615	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H9L23_RS12625	COG1045	serine acetyltransferase
H9L23_RS12640	COG2197	response regulator
H9L23_RS12660	COG3279	Response regulator of the LytR AlgR family
H9L23_RS12665	COG3275	phosphorelay sensor kinase activity
H9L23_RS12715	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H9L23_RS12720	COG0628	permease
H9L23_RS12730	COG0018	arginyl-trna synthetase
H9L23_RS12735	COG2235	arginine
H9L23_RS12750	COG1166	arginine decarboxylase activity
H9L23_RS12780	COG4172	Belongs to the ABC transporter superfamily
H9L23_RS12790	COG0557	exoribonuclease II activity
H9L23_RS12810	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H9L23_RS12815	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H9L23_RS12845	COG1301	dicarboxylic acid transport
H9L23_RS12850	COG1595	DNA-templated transcription, initiation
H9L23_RS12875	COG3525	Glycosyl hydrolase, family 20, catalytic domain
H9L23_RS12880	COG0492	ferredoxin-NADP+ reductase activity
H9L23_RS12885	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H9L23_RS12905	COG4771	TonB-dependent receptor
H9L23_RS12910	COG0516	GMP reductase activity
H9L23_RS12910	COG0517	IMP dehydrogenase activity
H9L23_RS12925	COG3123	guanosine phosphorylase activity
H9L23_RS12935	COG0612	Peptidase, M16
H9L23_RS12940	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
H9L23_RS12955	COG3279	Response regulator of the LytR AlgR family
H9L23_RS12960	COG3275	phosphorelay sensor kinase activity
H9L23_RS12980	COG0697	spore germination
H9L23_RS12985	COG1522	sequence-specific DNA binding
H9L23_RS12995	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H9L23_RS13000	COG2264	protein methyltransferase activity
H9L23_RS13005	COG0149	triose-phosphate isomerase activity
H9L23_RS13015	COG0254	rRNA binding
H9L23_RS13035	COG0346	lactoylglutathione lyase activity
H9L23_RS13045	COG0822	iron-sulfur transferase activity
H9L23_RS13050	COG0316	Belongs to the HesB IscA family
H9L23_RS13055	COG1022	Amp-dependent synthetase and ligase
H9L23_RS13060	COG4680	protein conserved in bacteria
H9L23_RS13070	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H9L23_RS13090	COG0339	signal peptide processing
H9L23_RS13105	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H9L23_RS13140	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H9L23_RS13145	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H9L23_RS13150	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H9L23_RS13155	COG2363	Small membrane protein
H9L23_RS13170	COG1214	PFAM Peptidase M22, glycoprotease
H9L23_RS13180	COG0594	ribonuclease P activity
H9L23_RS13185	COG0230	Belongs to the bacterial ribosomal protein bL34 family
H9L23_RS13190	COG3279	Response regulator of the LytR AlgR family
H9L23_RS13195	COG3275	phosphorelay sensor kinase activity
H9L23_RS13215	COG1970	mechanosensitive ion channel activity
H9L23_RS13220	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
H9L23_RS13240	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H9L23_RS13245	COG1078	dGTPase activity
H9L23_RS13285	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
H9L23_RS13310	COG3250	beta-galactosidase activity
H9L23_RS13320	COG2814	Major facilitator Superfamily
H9L23_RS13330	COG1309	transcriptional regulator
H9L23_RS13360	COG0745	RESPONSE REGULATOR receiver
H9L23_RS13380	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H9L23_RS13395	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H9L23_RS13410	COG0456	acetyltransferase
H9L23_RS13425	COG2207	Transcriptional regulator
H9L23_RS13425	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H9L23_RS13505	COG2003	Belongs to the UPF0758 family
H9L23_RS13515	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H9L23_RS13520	COG0443	Heat shock 70 kDa protein
H9L23_RS13530	COG1278	Cold shock
H9L23_RS13540	COG0667	Aldo Keto reductase
H9L23_RS13555	COG2133	pyrroloquinoline quinone binding
H9L23_RS13565	COG1011	Hydrolase
H9L23_RS13585	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H9L23_RS13600	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
H9L23_RS13610	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H9L23_RS13620	COG3279	Response regulator of the LytR AlgR family
H9L23_RS13625	COG2202	Pas domain
H9L23_RS13625	COG2205	protein histidine kinase activity
H9L23_RS13640	COG0436	Aminotransferase
H9L23_RS13660	COG0671	phosphoesterase, PA-phosphatase related
H9L23_RS13685	COG1733	regulation of RNA biosynthetic process
H9L23_RS13695	COG0673	inositol 2-dehydrogenase activity
H9L23_RS13700	COG0604	alcohol dehydrogenase
H9L23_RS13700	COG3321	synthase
H9L23_RS13700	COG1028	Short-chain dehydrogenase reductase Sdr
H9L23_RS13710	COG1132	(ABC) transporter
H9L23_RS13730	COG1595	DNA-templated transcription, initiation
H9L23_RS13740	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
H9L23_RS13745	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H9L23_RS13760	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
H9L23_RS13765	COG0746	molybdenum cofactor guanylyltransferase activity
H9L23_RS13770	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H9L23_RS13795	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H9L23_RS13805	COG0315	cyclic pyranopterin monophosphate synthase activity
H9L23_RS13805	COG0521	Mo-molybdopterin cofactor biosynthetic process
H9L23_RS13820	COG1278	Cold shock
H9L23_RS13830	COG3250	beta-galactosidase activity
H9L23_RS13850	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
H9L23_RS13855	COG1629	transport
H9L23_RS13855	COG4206	TonB-dependent receptor
H9L23_RS13860	COG0745	RESPONSE REGULATOR receiver
H9L23_RS13860	COG2205	protein histidine kinase activity
H9L23_RS13860	COG3292	Two component regulator propeller
H9L23_RS13870	COG1132	(ABC) transporter
H9L23_RS13875	COG1132	(ABC) transporter
H9L23_RS13885	COG2996	Protein conserved in bacteria
H9L23_RS13910	COG2226	methyltransferase
H9L23_RS13920	COG1595	DNA-templated transcription, initiation
H9L23_RS13940	COG1064	alcohol dehydrogenase
H9L23_RS13945	COG0494	nUDIX hydrolase
H9L23_RS13960	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H9L23_RS13970	COG3408	Glycogen debranching enzyme
H9L23_RS13975	COG0542	response to heat
H9L23_RS14000	COG2223	nitrite transmembrane transporter activity
H9L23_RS14040	COG0726	polysaccharide deacetylase
H9L23_RS14050	COG1649	PFAM Uncharacterised BCR, COG1649
H9L23_RS14050	COG0726	polysaccharide deacetylase
H9L23_RS14065	COG0778	Nitroreductase
H9L23_RS14080	COG0488	(ABC) transporter
H9L23_RS14110	COG1331	Highly conserved protein containing a thioredoxin domain
H9L23_RS14115	COG4804	nuclease activity
H9L23_RS14120	COG4948	Mandelate Racemase Muconate Lactonizing
H9L23_RS14125	COG3757	hydrolase, family 25
H9L23_RS14140	COG2814	Major facilitator Superfamily
H9L23_RS14175	COG0210	DNA helicase
H9L23_RS14180	COG1196	nuclear chromosome segregation
H9L23_RS14195	COG2234	aminopeptidase activity
H9L23_RS14210	COG0357	Ribosomal RNA small subunit methyltransferase G
H9L23_RS14215	COG1215	transferase activity, transferring glycosyl groups
H9L23_RS14220	COG0343	queuine tRNA-ribosyltransferase activity
H9L23_RS14255	COG1741	Belongs to the pirin family
H9L23_RS14285	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
H9L23_RS14290	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
H9L23_RS14300	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H9L23_RS14305	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H9L23_RS14315	COG1252	NADH dehydrogenase
H9L23_RS14335	COG0191	fructose-bisphosphate aldolase activity
H9L23_RS14340	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H9L23_RS14370	COG1271	oxidase subunit
H9L23_RS14390	COG1104	cysteine desulfurase activity
H9L23_RS14395	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H9L23_RS14400	COG2226	methyltransferase
H9L23_RS14415	COG4636	protein conserved in cyanobacteria
H9L23_RS14420	COG4636	protein conserved in cyanobacteria
H9L23_RS14435	COG0237	dephospho-CoA kinase activity
H9L23_RS14450	COG1862	Preprotein translocase
H9L23_RS14460	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H9L23_RS14470	COG1132	(ABC) transporter
H9L23_RS14485	COG0012	GTP binding
H9L23_RS14500	COG2239	Acts as a magnesium transporter
H9L23_RS14510	COG1522	sequence-specific DNA binding
H9L23_RS14515	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H9L23_RS14525	COG4232	protein-disulfide reductase activity
H9L23_RS14530	COG1595	DNA-templated transcription, initiation
H9L23_RS14540	COG1629	transport
H9L23_RS14545	COG0702	epimerase
H9L23_RS14550	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H9L23_RS14555	COG3781	membrane
H9L23_RS14570	COG0583	DNA-binding transcription factor activity
H9L23_RS14585	COG4206	TonB-dependent receptor
H9L23_RS14585	COG1629	transport
H9L23_RS14630	COG0702	epimerase
H9L23_RS14655	COG1940	carbohydrate kinase activity
H9L23_RS14660	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
H9L23_RS14665	COG5434	Belongs to the glycosyl hydrolase 28 family
H9L23_RS14695	COG4771	TonB-dependent receptor
H9L23_RS14705	COG3119	arylsulfatase activity
H9L23_RS14725	COG1629	transport
H9L23_RS14735	COG3264	Mechanosensitive ion channel
H9L23_RS14735	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
H9L23_RS14755	COG0662	Cupin 2, conserved barrel domain protein
H9L23_RS14755	COG2207	Transcriptional regulator
H9L23_RS14760	COG1629	transport
H9L23_RS14790	COG3386	PFAM SMP-30 Gluconolaconase
H9L23_RS14805	COG3250	beta-galactosidase activity
H9L23_RS14810	COG3250	beta-galactosidase activity
H9L23_RS14815	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H9L23_RS14825	COG1131	(ABC) transporter
H9L23_RS14845	COG3321	synthase
H9L23_RS14845	COG0604	alcohol dehydrogenase
H9L23_RS14850	COG0318	PFAM AMP-dependent synthetase and ligase
H9L23_RS14850	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H9L23_RS14850	COG1028	Short-chain dehydrogenase reductase Sdr
H9L23_RS14850	COG3321	synthase
H9L23_RS14850	COG0300	oxidoreductase activity
H9L23_RS14855	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H9L23_RS14860	COG0596	Alpha beta hydrolase
H9L23_RS14900	COG0596	Alpha beta hydrolase
H9L23_RS14910	COG3279	Response regulator of the LytR AlgR family
H9L23_RS14920	COG2234	aminopeptidase activity
H9L23_RS14925	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
H9L23_RS14930	COG1752	Esterase of the alpha-beta hydrolase superfamily
H9L23_RS14950	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H9L23_RS14980	COG0167	dihydroorotate dehydrogenase activity
H9L23_RS14990	COG1959	2 iron, 2 sulfur cluster binding
H9L23_RS14995	COG0488	(ABC) transporter
H9L23_RS15010	COG0673	inositol 2-dehydrogenase activity
H9L23_RS15015	COG1477	protein flavinylation
H9L23_RS15020	COG3622	Belongs to the hyi family
H9L23_RS15030	COG1607	acyl-coa hydrolase
H9L23_RS15090	COG1464	Belongs to the NlpA lipoprotein family
H9L23_RS15155	COG0673	inositol 2-dehydrogenase activity
H9L23_RS15165	COG0673	inositol 2-dehydrogenase activity
H9L23_RS15170	COG0525	valine-tRNA ligase activity
H9L23_RS15190	COG2217	Heavy metal translocating P-type atpase
H9L23_RS15195	COG3590	peptidase
H9L23_RS15220	COG0667	Aldo Keto reductase
H9L23_RS15225	COG0628	permease
H9L23_RS15240	COG3956	TIGRFAM MazG family protein
H9L23_RS15250	COG3012	SEC-C Motif Domain Protein
H9L23_RS15255	COG0101	tRNA pseudouridine synthase activity
H9L23_RS15265	COG4591	ABC-type transport system involved in lipoprotein release permease component
H9L23_RS15270	COG3876	Protein conserved in bacteria
H9L23_RS15280	COG5002	protein histidine kinase activity
H9L23_RS15290	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H9L23_RS15305	COG0564	pseudouridine synthase activity
H9L23_RS15315	COG2515	1-aminocyclopropane-1-carboxylate deaminase
H9L23_RS15320	COG1309	transcriptional regulator
H9L23_RS15335	COG4771	TonB-dependent receptor
H9L23_RS15350	COG3250	beta-galactosidase activity
H9L23_RS15365	COG1629	transport
H9L23_RS15375	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
H9L23_RS15385	COG1629	transport
H9L23_RS15395	COG3940	Belongs to the glycosyl hydrolase 43 family
H9L23_RS15400	COG3254	rhamnose metabolic process
H9L23_RS15415	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
H9L23_RS15425	COG2755	lipolytic protein G-D-S-L family
H9L23_RS15430	COG2755	lipolytic protein G-D-S-L family
H9L23_RS15435	COG3401	FG-GAP repeat protein
H9L23_RS15460	COG1082	Xylose isomerase domain protein TIM barrel
H9L23_RS15470	COG3507	Belongs to the glycosyl hydrolase 43 family
H9L23_RS15495	COG0702	epimerase
H9L23_RS15500	COG4771	TonB-dependent receptor
H9L23_RS15525	COG4771	TonB-dependent receptor
H9L23_RS15550	COG3292	Two component regulator propeller
H9L23_RS15550	COG0745	RESPONSE REGULATOR receiver
H9L23_RS15550	COG2205	protein histidine kinase activity
H9L23_RS15570	COG1960	acyl-CoA dehydrogenase activity
H9L23_RS15580	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H9L23_RS15585	COG0386	Belongs to the glutathione peroxidase family
H9L23_RS15595	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H9L23_RS15605	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H9L23_RS15620	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H9L23_RS15630	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
H9L23_RS15645	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
H9L23_RS15660	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H9L23_RS15685	COG1528	Iron-storage protein
H9L23_RS15690	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H9L23_RS15715	COG0539	negative regulation of cytoplasmic translation
H9L23_RS15715	COG2183	response to ionizing radiation
H9L23_RS15720	COG3525	Glycosyl hydrolase, family 20, catalytic domain
H9L23_RS15730	COG2207	Transcriptional regulator
H9L23_RS15735	COG1012	belongs to the aldehyde dehydrogenase family
H9L23_RS15750	COG3011	Protein conserved in bacteria
H9L23_RS15760	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
H9L23_RS15765	COG0540	Belongs to the ATCase OTCase family
H9L23_RS15790	COG4771	TonB-dependent receptor
H9L23_RS15805	COG1940	carbohydrate kinase activity
H9L23_RS15810	COG2188	Transcriptional regulator
H9L23_RS15820	COG2814	Major facilitator Superfamily
H9L23_RS15835	COG3537	Alpha-1,2-mannosidase
H9L23_RS15840	COG1629	transport
H9L23_RS15860	COG0811	peptide transport
H9L23_RS15865	COG0848	biopolymer transport protein
H9L23_RS15895	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
H9L23_RS15960	COG0497	DNA recombination
H9L23_RS15990	COG0542	response to heat
H9L23_RS16010	COG3325	Belongs to the glycosyl hydrolase 18 family
H9L23_RS16010	COG3469	chitinase activity
H9L23_RS16035	COG0488	(ABC) transporter
H9L23_RS16060	COG4807	Protein conserved in bacteria
H9L23_RS16065	COG0513	Belongs to the DEAD box helicase family
H9L23_RS16095	COG0004	ammonium transporteR
H9L23_RS16100	COG1242	4 iron, 4 sulfur cluster binding
H9L23_RS16170	COG0531	amino acid
H9L23_RS16175	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
H9L23_RS16180	COG0531	amino acid
H9L23_RS16190	COG2095	MarC family integral membrane protein
H9L23_RS16195	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H9L23_RS16205	COG0519	Catalyzes the synthesis of GMP from XMP
H9L23_RS16205	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H9L23_RS16225	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
H9L23_RS16250	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H9L23_RS16255	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
H9L23_RS16270	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H9L23_RS16280	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H9L23_RS16295	COG1610	YqeY-like protein
H9L23_RS16310	COG2226	methyltransferase
H9L23_RS16315	COG0218	Necessary for normal cell division and for the maintenance of normal septation
H9L23_RS16320	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H9L23_RS16335	COG2814	Major facilitator Superfamily
H9L23_RS16340	COG0531	amino acid
H9L23_RS16340	COG0531	amino acid
H9L23_RS16350	COG1943	Transposase
H9L23_RS16355	COG3158	transport of potassium into the cell
H9L23_RS16365	COG0179	Fumarylacetoacetate (FAA) hydrolase
H9L23_RS16375	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H9L23_RS16380	COG3959	Transketolase, thiamine diphosphate binding domain
H9L23_RS16385	COG3958	Transketolase
H9L23_RS16390	COG1595	DNA-templated transcription, initiation
H9L23_RS16425	COG3279	Response regulator of the LytR AlgR family
H9L23_RS16430	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H9L23_RS16435	COG0745	RESPONSE REGULATOR receiver
H9L23_RS16440	COG5002	protein histidine kinase activity
H9L23_RS16450	COG4771	TonB-dependent receptor
H9L23_RS16455	COG0702	epimerase
H9L23_RS16460	COG1472	Belongs to the glycosyl hydrolase 3 family
H9L23_RS16480	COG0564	pseudouridine synthase activity
H9L23_RS16485	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H9L23_RS16490	COG0505	Belongs to the CarA family
H9L23_RS16515	COG1309	transcriptional regulator
H9L23_RS16525	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H9L23_RS16530	COG0156	8-amino-7-oxononanoate synthase activity
H9L23_RS16540	COG1054	Belongs to the UPF0176 family
H9L23_RS16560	COG0702	epimerase
H9L23_RS16590	COG1472	Belongs to the glycosyl hydrolase 3 family
H9L23_RS16600	COG0217	transcriptional regulatory protein
H9L23_RS16605	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H9L23_RS16640	COG0673	inositol 2-dehydrogenase activity
H9L23_RS16650	COG4654	Cytochrome c, class I
H9L23_RS16655	COG0673	inositol 2-dehydrogenase activity
H9L23_RS16665	COG2211	Major facilitator Superfamily
H9L23_RS16670	COG1082	Xylose isomerase domain protein TIM barrel
H9L23_RS16685	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H9L23_RS16720	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H9L23_RS16730	COG0148	phosphopyruvate hydratase activity
H9L23_RS16740	COG2860	membrane
H9L23_RS16750	COG3034	peptidoglycan biosynthetic process
H9L23_RS16755	COG1028	Short-chain dehydrogenase reductase Sdr
H9L23_RS16790	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H9L23_RS16790	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H9L23_RS16800	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H9L23_RS16800	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H9L23_RS16805	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H9L23_RS16815	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
H9L23_RS16830	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
H9L23_RS16835	COG1301	dicarboxylic acid transport
H9L23_RS16840	COG1446	asparaginase
H9L23_RS16845	COG1132	(ABC) transporter
H9L23_RS16850	COG0101	tRNA pseudouridine synthase activity
H9L23_RS16865	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
H9L23_RS16900	COG1629	transport
H9L23_RS16900	COG4206	TonB-dependent receptor
H9L23_RS16905	COG1940	carbohydrate kinase activity
H9L23_RS16905	COG1846	Transcriptional regulator
H9L23_RS16935	COG1629	transport
H9L23_RS16935	COG4206	TonB-dependent receptor
H9L23_RS16940	COG0681	Belongs to the peptidase S26 family
H9L23_RS16945	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H9L23_RS16955	COG1475	DNA binding
H9L23_RS16960	COG1192	Involved in chromosome partitioning
H9L23_RS16970	COG5002	protein histidine kinase activity
H9L23_RS16980	COG1082	Xylose isomerase domain protein TIM barrel
H9L23_RS17005	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H9L23_RS17010	COG0563	adenylate kinase activity
H9L23_RS17050	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H9L23_RS17060	COG3549	Plasmid maintenance system killer
H9L23_RS17070	COG2267	carboxylic ester hydrolase activity
H9L23_RS17085	COG0129	dihydroxy-acid dehydratase activity
H9L23_RS17095	COG0028	Belongs to the TPP enzyme family
H9L23_RS17100	COG0440	acetolactate synthase activity
H9L23_RS17115	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H9L23_RS17120	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H9L23_RS17125	COG2329	Antibiotic biosynthesis monooxygenase
H9L23_RS17130	COG0066	3-isopropylmalate dehydratase activity
H9L23_RS17135	COG1119	ATPase activity
H9L23_RS17140	COG0473	3-isopropylmalate dehydrogenase activity
H9L23_RS17145	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H9L23_RS17150	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H9L23_RS17155	COG1917	Cupin 2, conserved barrel domain protein
H9L23_RS17205	COG1981	membrane
H9L23_RS17220	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
H9L23_RS17230	COG0745	RESPONSE REGULATOR receiver
H9L23_RS17235	COG5002	protein histidine kinase activity
H9L23_RS17240	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H9L23_RS17245	COG0113	porphobilinogen synthase activity
H9L23_RS17250	COG0181	hydroxymethylbilane synthase activity
H9L23_RS17260	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
H9L23_RS17270	COG0596	Alpha beta hydrolase
H9L23_RS17280	COG0668	transmembrane transport
H9L23_RS17285	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
H9L23_RS17290	COG2267	carboxylic ester hydrolase activity
H9L23_RS17310	COG1028	Short-chain dehydrogenase reductase Sdr
H9L23_RS17315	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H9L23_RS17320	COG1127	ABC transporter
H9L23_RS17335	COG0116	Belongs to the methyltransferase superfamily
H9L23_RS17335	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H9L23_RS17390	COG1295	ribonuclease BN
H9L23_RS17400	COG0531	amino acid
H9L23_RS17415	COG1629	transport
H9L23_RS17420	COG0513	Belongs to the DEAD box helicase family
H9L23_RS17425	COG0495	leucyl-tRNA aminoacylation
H9L23_RS17435	COG2177	Part of the ABC transporter FtsEX involved in
H9L23_RS17455	COG1968	undecaprenyl-diphosphatase activity
H9L23_RS17460	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H9L23_RS17465	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H9L23_RS17470	COG0196	riboflavin kinase activity
H9L23_RS17490	COG0432	Pfam Uncharacterised protein family UPF0047
H9L23_RS17495	COG1295	ribonuclease BN
H9L23_RS17500	COG1073	alpha beta
H9L23_RS17510	COG2764	glyoxalase bleomycin resistance protein dioxygenase
H9L23_RS17515	COG2169	Transcriptional regulator
H9L23_RS17525	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
H9L23_RS17585	COG4771	TonB-dependent receptor
H9L23_RS17590	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H9L23_RS17600	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H9L23_RS17605	COG0612	Peptidase, M16
H9L23_RS17610	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
H9L23_RS17615	COG3237	CsbD-like
H9L23_RS17620	COG4771	TonB-dependent receptor
H9L23_RS17635	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
H9L23_RS17640	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H9L23_RS17645	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H9L23_RS17650	COG0267	Belongs to the bacterial ribosomal protein bL33 family
H9L23_RS17670	COG0552	protein localization to endoplasmic reticulum
H9L23_RS17680	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H9L23_RS17690	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H9L23_RS17705	COG0726	polysaccharide deacetylase
H9L23_RS17725	COG2723	6-phospho-beta-galactosidase activity
H9L23_RS17770	COG2801	Transposase and inactivated derivatives
H9L23_RS17785	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
H9L23_RS17795	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H9L23_RS17815	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
H9L23_RS17820	COG1663	tetraacyldisaccharide 4'-kinase activity
H9L23_RS17830	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H9L23_RS17850	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H9L23_RS17855	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H9L23_RS17865	COG1012	belongs to the aldehyde dehydrogenase family
H9L23_RS17870	COG3119	arylsulfatase activity
H9L23_RS17885	COG4948	Mandelate Racemase Muconate Lactonizing
H9L23_RS17890	COG4771	TonB-dependent receptor
H9L23_RS17895	COG0702	epimerase
H9L23_RS17935	COG0288	reversible hydration of carbon dioxide
H9L23_RS17940	COG0659	secondary active sulfate transmembrane transporter activity
H9L23_RS17955	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H9L23_RS17960	COG2814	Major facilitator Superfamily
H9L23_RS17975	COG1363	Peptidase, m42
H9L23_RS17985	COG2801	Transposase and inactivated derivatives
H9L23_RS17995	COG0588	phosphoglycerate mutase activity
H9L23_RS18005	COG0708	Exodeoxyribonuclease III
H9L23_RS18020	COG2205	protein histidine kinase activity
H9L23_RS18020	COG3292	Two component regulator propeller
H9L23_RS18020	COG0745	RESPONSE REGULATOR receiver
H9L23_RS18025	COG1595	DNA-templated transcription, initiation
H9L23_RS18035	COG5002	protein histidine kinase activity
H9L23_RS18065	COG0433	COG0433 Predicted ATPase
H9L23_RS18080	COG0443	Heat shock 70 kDa protein
H9L23_RS18110	COG2801	Transposase and inactivated derivatives
H9L23_RS18125	COG0203	ribosomal protein L17
H9L23_RS18130	COG0202	RNA polymerase activity
H9L23_RS18135	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H9L23_RS18140	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
H9L23_RS18145	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H9L23_RS18150	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H9L23_RS18155	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
H9L23_RS18170	COG0200	Binds to the 23S rRNA
H9L23_RS18175	COG1841	ribosomal large subunit assembly
H9L23_RS18180	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
H9L23_RS18185	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H9L23_RS18190	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H9L23_RS18195	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H9L23_RS18200	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H9L23_RS18205	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H9L23_RS18210	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H9L23_RS18215	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H9L23_RS18220	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H9L23_RS18225	COG0255	Belongs to the universal ribosomal protein uL29 family
H9L23_RS18230	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H9L23_RS18235	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H9L23_RS18240	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H9L23_RS18245	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H9L23_RS18250	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H9L23_RS18255	COG0089	rRNA binding
H9L23_RS18260	COG0088	Forms part of the polypeptide exit tunnel
H9L23_RS18265	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H9L23_RS18275	COG0730	response to heat
H9L23_RS18315	COG0232	Belongs to the dGTPase family. Type 2 subfamily
H9L23_RS18345	COG0051	transcription antitermination factor activity, RNA binding
H9L23_RS18350	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H9L23_RS18355	COG0049	tRNA binding
H9L23_RS18360	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H9L23_RS18375	COG0702	epimerase
H9L23_RS18380	COG4771	TonB-dependent receptor
H9L23_RS18385	COG0529	Catalyzes the synthesis of activated sulfate
H9L23_RS18390	COG1218	3'(2'),5'-bisphosphate nucleotidase
H9L23_RS18400	COG2059	Chromate
H9L23_RS18420	COG4628	conserved protein (DUF2132)
H9L23_RS18445	COG1393	Belongs to the ArsC family
H9L23_RS18450	COG3275	phosphorelay sensor kinase activity
H9L23_RS18455	COG2827	Endonuclease containing a URI domain
H9L23_RS18460	COG3279	Response regulator of the LytR AlgR family
H9L23_RS18465	COG2373	Large extracellular alpha-helical protein
H9L23_RS18470	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H9L23_RS18480	COG0579	oxidoreductase
H9L23_RS18495	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H9L23_RS18530	COG1574	metal-dependent hydrolase with the TIM-barrel fold
H9L23_RS18540	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H9L23_RS18560	COG0778	Nitroreductase
H9L23_RS18570	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H9L23_RS18605	COG4771	TonB-dependent receptor
H9L23_RS18625	COG0326	Molecular chaperone. Has ATPase activity
H9L23_RS18705	COG0346	lactoylglutathione lyase activity
H9L23_RS18720	COG1381	Involved in DNA repair and RecF pathway recombination
H9L23_RS18745	COG0300	oxidoreductase activity
H9L23_RS18750	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H9L23_RS18770	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H9L23_RS18775	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H9L23_RS18780	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H9L23_RS18800	COG0567	Dehydrogenase, E1 component
H9L23_RS18805	COG0415	Belongs to the DNA photolyase family
H9L23_RS18810	COG1090	epimerase
H9L23_RS18815	COG0415	Belongs to the DNA photolyase family
H9L23_RS18835	COG0545	Peptidyl-prolyl cis-trans isomerase
H9L23_RS18840	COG1960	acyl-CoA dehydrogenase activity
H9L23_RS18850	COG0183	Belongs to the thiolase family
H9L23_RS18855	COG1250	3-hydroxyacyl-CoA dehydrogenase
H9L23_RS18855	COG1024	Enoyl-CoA hydratase
H9L23_RS18875	COG2885	chlorophyll binding
H9L23_RS18885	COG0405	Gamma-glutamyltransferase
H9L23_RS18905	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H9L23_RS18910	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H9L23_RS18935	COG0326	Molecular chaperone. Has ATPase activity
H9L23_RS18965	COG2972	Histidine kinase
H9L23_RS18995	COG1360	Flagellar Motor Protein
H9L23_RS19035	COG4206	TonB-dependent receptor
H9L23_RS19035	COG1629	transport
H9L23_RS19045	COG1595	DNA-templated transcription, initiation
H9L23_RS19050	COG2322	membrane
H9L23_RS19065	COG1845	cytochrome c oxidase, subunit III
H9L23_RS19075	COG0109	protoheme IX farnesyltransferase activity
H9L23_RS19085	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H9L23_RS19090	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H9L23_RS19115	COG0437	4 iron, 4 sulfur cluster binding
H9L23_RS19155	COG0860	N-Acetylmuramoyl-L-alanine amidase
H9L23_RS19160	COG3682	Transcriptional regulator
H9L23_RS19195	COG2273	Hydrolase Family 16
H9L23_RS19195	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
H9L23_RS19215	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
H9L23_RS19270	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H9L23_RS19275	COG1215	transferase activity, transferring glycosyl groups
H9L23_RS19285	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
H9L23_RS19320	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H9L23_RS19325	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H9L23_RS19330	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H9L23_RS19335	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H9L23_RS19340	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H9L23_RS19370	COG0322	excinuclease ABC activity
H9L23_RS19415	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H9L23_RS19425	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
H9L23_RS19445	COG0110	maltose O-acetyltransferase activity
H9L23_RS19460	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H9L23_RS19485	COG0745	RESPONSE REGULATOR receiver
H9L23_RS19525	COG1694	Mazg nucleotide pyrophosphohydrolase
H9L23_RS19535	COG1490	D-aminoacyl-tRNA deacylase activity
H9L23_RS19550	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H9L23_RS19555	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H9L23_RS19565	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H9L23_RS19570	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H9L23_RS19590	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H9L23_RS19595	COG0416	fatty acid biosynthetic process
H9L23_RS19600	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H9L23_RS19605	COG0511	ligase activity, forming carbon-carbon bonds
H9L23_RS19610	COG0439	Biotin carboxylase
H9L23_RS19620	COG0805	protein transport
H9L23_RS19625	COG0698	ribose 5-phosphate isomerase
H9L23_RS19630	COG2234	aminopeptidase activity
H9L23_RS19635	COG1139	Iron-sulfur cluster binding protein
H9L23_RS19640	COG0022	dehydrogenase e1 component
H9L23_RS19645	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
H9L23_RS19660	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H9L23_RS19665	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H9L23_RS19680	COG3541	Predicted nucleotidyltransferase
H9L23_RS19690	COG1690	Belongs to the RtcB family
H9L23_RS19695	COG0436	Aminotransferase
H9L23_RS19710	COG0165	Argininosuccinate lyase
H9L23_RS19715	COG4946	Tricorn protease homolog
H9L23_RS19715	COG0823	Involved in the tonB-independent uptake of proteins
H9L23_RS19715	COG1506	peptidase
H9L23_RS19735	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H9L23_RS19745	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H9L23_RS19755	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H9L23_RS19765	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H9L23_RS19770	COG0456	acetyltransferase
H9L23_RS19780	COG0137	argininosuccinate synthase activity
H9L23_RS19820	COG4935	Belongs to the peptidase S8 family
H9L23_RS19820	COG2234	aminopeptidase activity
H9L23_RS19835	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H9L23_RS19845	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
H9L23_RS19865	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
H9L23_RS19900	COG3848	Pyruvate phosphate dikinase
H9L23_RS19900	COG0574	Belongs to the PEP-utilizing enzyme family
H9L23_RS19915	COG0469	pyruvate kinase activity
H9L23_RS19925	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H9L23_RS19930	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H9L23_RS19935	COG0571	ribonuclease III activity
H9L23_RS19960	COG1561	YicC-like family, N-terminal region
H9L23_RS19965	COG0194	GDP metabolic process
H9L23_RS19975	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H9L23_RS19980	COG1472	Belongs to the glycosyl hydrolase 3 family
H9L23_RS20000	COG4804	nuclease activity
H9L23_RS20005	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H9L23_RS20010	COG1074	ATP-dependent DNA helicase activity
H9L23_RS20025	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H9L23_RS20045	COG0508	dehydrogenase complex catalyzes the overall conversion of
H9L23_RS20045	COG0022	dehydrogenase e1 component
H9L23_RS20060	COG2183	response to ionizing radiation
H9L23_RS20095	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H9L23_RS20100	COG0052	Belongs to the universal ribosomal protein uS2 family
H9L23_RS20105	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H9L23_RS20110	COG2801	Transposase and inactivated derivatives
H9L23_RS20115	COG2801	Transposase and inactivated derivatives
H9L23_RS20130	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H9L23_RS20145	COG0528	UMP kinase activity
H9L23_RS20150	COG0233	cytoplasmic translational termination
H9L23_RS20170	COG1522	sequence-specific DNA binding
H9L23_RS20200	COG0509	glycine decarboxylation via glycine cleavage system
H9L23_RS20210	COG0632	four-way junction helicase activity
H9L23_RS20215	COG0281	malic enzyme
H9L23_RS20215	COG0280	phosphate acetyltransferase
H9L23_RS20220	COG1388	LysM domain
H9L23_RS20220	COG3942	CHAP domain
H9L23_RS20225	COG0154	amidase activity
H9L23_RS20230	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H9L23_RS20235	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H9L23_RS20255	COG0756	dUTP diphosphatase activity
H9L23_RS20265	COG1254	Belongs to the acylphosphatase family
H9L23_RS20275	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H9L23_RS20310	COG2204	response regulator
H9L23_RS20315	COG0784	Response regulator, receiver
H9L23_RS20315	COG2198	Histidine kinase
H9L23_RS20315	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H9L23_RS20315	COG2205	protein histidine kinase activity
H9L23_RS20320	COG2378	regulation of single-species biofilm formation
H9L23_RS20345	COG1187	pseudouridine synthase activity
H9L23_RS20350	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H9L23_RS20390	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H9L23_RS20395	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H9L23_RS20400	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
H9L23_RS20405	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H9L23_RS20425	COG0662	Cupin 2, conserved barrel domain protein
H9L23_RS20425	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
H9L23_RS20435	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
H9L23_RS20445	COG0438	transferase activity, transferring glycosyl groups
H9L23_RS20490	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H9L23_RS20495	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H9L23_RS20500	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
H9L23_RS20515	COG4464	protein tyrosine phosphatase activity
H9L23_RS20520	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
H9L23_RS20590	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H9L23_RS20605	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
H9L23_RS20645	COG1090	epimerase
H9L23_RS20735	COG1525	nuclease
H9L23_RS20770	COG3422	double-strand break repair
H9L23_RS20780	COG4585	Histidine kinase
H9L23_RS20805	COG3279	Response regulator of the LytR AlgR family
H9L23_RS20875	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H9L23_RS20895	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H9L23_RS20900	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H9L23_RS20905	COG2022	thiamine diphosphate biosynthetic process
H9L23_RS20910	COG0352	thiamine-phosphate diphosphorylase activity
H9L23_RS20915	COG0352	thiamine-phosphate diphosphorylase activity
H9L23_RS20920	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
H9L23_RS20955	COG2195	Cleaves the N-terminal amino acid of tripeptides
H9L23_RS20985	COG4948	Mandelate Racemase Muconate Lactonizing
H9L23_RS20990	COG1054	Belongs to the UPF0176 family
H9L23_RS21005	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H9L23_RS21025	COG0352	thiamine-phosphate diphosphorylase activity
H9L23_RS21065	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H9L23_RS21065	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H9L23_RS21070	COG1024	Enoyl-CoA hydratase
H9L23_RS21075	COG2204	response regulator
H9L23_RS21100	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H9L23_RS21105	COG4680	protein conserved in bacteria
H9L23_RS21155	COG3781	membrane
H9L23_RS21170	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H9L23_RS21180	COG4771	TonB-dependent receptor
H9L23_RS21185	COG0702	epimerase
H9L23_RS21195	COG4677	pectinesterase activity
H9L23_RS21200	COG2755	lipolytic protein G-D-S-L family
H9L23_RS21205	COG1012	belongs to the aldehyde dehydrogenase family
H9L23_RS21225	COG1904	glucuronate isomerase
H9L23_RS21230	COG2721	sulfolactate sulfo-lyase activity
H9L23_RS21235	COG0246	Mannitol dehydrogenase
H9L23_RS21245	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
H9L23_RS21265	COG2755	lipolytic protein G-D-S-L family
H9L23_RS21270	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H9L23_RS21300	COG1012	belongs to the aldehyde dehydrogenase family
H9L23_RS21320	COG1629	transport
H9L23_RS21340	COG1809	phosphosulfolactate synthase activity
H9L23_RS21345	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H9L23_RS21355	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H9L23_RS21360	COG4591	ABC-type transport system involved in lipoprotein release permease component
H9L23_RS21380	COG1070	Carbohydrate kinase
H9L23_RS21385	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H9L23_RS21410	COG0583	DNA-binding transcription factor activity
H9L23_RS21420	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H9L23_RS21445	COG0519	Catalyzes the synthesis of GMP from XMP
H9L23_RS21490	COG4895	conserved protein (DUF2196)
H9L23_RS21500	COG0556	nucleotide-excision repair
H9L23_RS21525	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H9L23_RS21535	COG1011	Hydrolase
H9L23_RS21610	COG1446	asparaginase
H9L23_RS21645	COG0791	NLP P60 protein
H9L23_RS21650	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H9L23_RS21670	COG4297	protein containing double-stranded beta helix domain
H9L23_RS21675	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H9L23_RS21685	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H9L23_RS21690	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
H9L23_RS21700	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
H9L23_RS21705	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H9L23_RS21705	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H9L23_RS21710	COG1619	proteins homologs of microcin C7 resistance protein MccF
H9L23_RS21730	COG1629	transport
H9L23_RS21735	COG0702	epimerase
H9L23_RS21740	COG4771	TonB-dependent receptor
H9L23_RS21745	COG0702	epimerase
H9L23_RS21750	COG4771	TonB-dependent receptor
H9L23_RS21760	COG4771	TonB-dependent receptor
H9L23_RS21770	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H9L23_RS21785	COG1774	PSP1 C-terminal conserved region
H9L23_RS21790	COG0470	DNA polymerase III
H9L23_RS21795	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H9L23_RS21810	COG1705	Flagellar rod assembly protein muramidase FlgJ
H9L23_RS21855	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H9L23_RS21860	COG0606	chelatase, subunit chli
H9L23_RS21895	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
H9L23_RS21900	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H9L23_RS21915	COG0612	Peptidase, M16
H9L23_RS21920	COG0242	peptide deformylase activity
H9L23_RS21935	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
H9L23_RS21940	COG0489	protein tyrosine kinase activity
H9L23_RS21945	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H9L23_RS21955	COG0688	phosphatidylethanolamine metabolic process
H9L23_RS21965	COG0335	large ribosomal subunit rRNA binding
H9L23_RS21970	COG0336	Belongs to the RNA methyltransferase TrmD family
H9L23_RS21980	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H9L23_RS21985	COG0228	four-way junction DNA binding
H9L23_RS21990	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
H9L23_RS21995	COG1629	transport
H9L23_RS22000	COG0393	Putative heavy-metal-binding
H9L23_RS22005	COG0205	6-phosphofructokinase activity
H9L23_RS22010	COG4232	protein-disulfide reductase activity
H9L23_RS22025	COG0799	negative regulation of ribosome biogenesis
H9L23_RS22030	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H9L23_RS22035	COG1556	Lactate utilization protein
H9L23_RS22040	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H9L23_RS22055	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H9L23_RS22075	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H9L23_RS22080	COG3530	Putative quorum-sensing-regulated virulence factor
H9L23_RS22085	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H9L23_RS22095	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
H9L23_RS22100	COG1607	acyl-coa hydrolase
H9L23_RS22120	COG1266	CAAX protease self-immunity
H9L23_RS22125	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H9L23_RS22145	COG0788	formyltetrahydrofolate deformylase activity
H9L23_RS22160	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H9L23_RS22165	COG1301	dicarboxylic acid transport
H9L23_RS22170	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H9L23_RS22175	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
H9L23_RS22180	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H9L23_RS22190	COG0445	tRNA wobble uridine modification
H9L23_RS22195	COG0488	(ABC) transporter
H9L23_RS22200	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H9L23_RS22225	COG3511	phospholipase C
H9L23_RS22235	COG2197	response regulator
H9L23_RS22245	COG2207	Transcriptional regulator
H9L23_RS22245	COG0662	Cupin 2, conserved barrel domain protein
H9L23_RS22250	COG4771	TonB-dependent receptor
H9L23_RS22280	COG1309	transcriptional regulator
H9L23_RS22295	COG2814	Major facilitator Superfamily
H9L23_RS22300	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
H9L23_RS22320	COG0450	alkyl hydroperoxide reductase
H9L23_RS22365	COG3384	dioxygenase
H9L23_RS22370	COG2353	YceI-like domain
H9L23_RS22415	COG0708	Exodeoxyribonuclease III
H9L23_RS22420	COG1228	amidohydrolase
H9L23_RS22425	COG0010	Belongs to the arginase family
H9L23_RS22435	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H9L23_RS22445	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H9L23_RS22450	COG1131	(ABC) transporter
H9L23_RS22460	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H9L23_RS22470	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H9L23_RS22475	COG1078	dGTPase activity
H9L23_RS22490	COG0802	atpase or kinase
H9L23_RS22495	COG0686	Belongs to the AlaDH PNT family
H9L23_RS22520	COG0793	Belongs to the peptidase S41A family
H9L23_RS22520	COG3409	Peptidoglycan-binding domain 1 protein
H9L23_RS22555	COG1595	DNA-templated transcription, initiation
H9L23_RS22560	COG2076	Multidrug Resistance protein
H9L23_RS22575	COG2050	protein possibly involved in aromatic compounds catabolism
H9L23_RS22590	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H9L23_RS22600	COG5002	protein histidine kinase activity
H9L23_RS22605	COG2205	protein histidine kinase activity
H9L23_RS22605	COG0784	Response regulator, receiver
H9L23_RS22615	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H9L23_RS22625	COG0745	RESPONSE REGULATOR receiver
H9L23_RS22635	COG1704	LemA family
H9L23_RS22650	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H9L23_RS22655	COG2204	response regulator
H9L23_RS22675	COG5002	protein histidine kinase activity
H9L23_RS22685	COG0306	phosphate transporter
H9L23_RS22745	COG0513	Belongs to the DEAD box helicase family
H9L23_RS22760	COG1760	l-serine dehydratase
H9L23_RS22770	COG1285	pathogenesis
H9L23_RS22785	COG0459	protein refolding
H9L23_RS22790	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H9L23_RS22810	COG1418	mRNA catabolic process
H9L23_RS22850	COG0116	Belongs to the methyltransferase superfamily
H9L23_RS22850	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H9L23_RS22870	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
H9L23_RS22885	COG0302	gtp cyclohydrolase
H9L23_RS22890	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H9L23_RS22895	COG5000	phosphorelay sensor kinase activity
H9L23_RS22905	COG1649	PFAM Uncharacterised BCR, COG1649
H9L23_RS22920	COG0363	glucosamine-6-phosphate deaminase activity
H9L23_RS22925	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H9L23_RS22940	COG1349	DNA-binding transcription factor activity
H9L23_RS22945	COG4771	TonB-dependent receptor
H9L23_RS22960	COG1629	transport
H9L23_RS22995	COG3537	Alpha-1,2-mannosidase
H9L23_RS23000	COG3250	beta-galactosidase activity
H9L23_RS23010	COG0492	ferredoxin-NADP+ reductase activity
H9L23_RS23020	COG1505	serine-type exopeptidase activity
H9L23_RS23030	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H9L23_RS23040	COG0288	reversible hydration of carbon dioxide
H9L23_RS23115	COG0542	response to heat
H9L23_RS23240	COG3209	COG3209 Rhs family protein
H9L23_RS23285	COG2986	histidine ammonia-lyase
H9L23_RS23300	COG0583	DNA-binding transcription factor activity
H9L23_RS23305	COG2249	NAD(P)H dehydrogenase (quinone) activity
H9L23_RS23325	COG2032	superoxide dismutase activity
H9L23_RS23345	COG2274	protein secretion by the type I secretion system
H9L23_RS23350	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H9L23_RS23365	COG2972	Histidine kinase
H9L23_RS23370	COG3279	Response regulator of the LytR AlgR family
H9L23_RS23385	COG0124	histidyl-tRNA synthetase
H9L23_RS23405	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H9L23_RS23415	COG4152	abc transporter atp-binding protein
H9L23_RS23430	COG0673	inositol 2-dehydrogenase activity
H9L23_RS23435	COG3228	Belongs to the MtfA family
H9L23_RS23455	COG1725	Transcriptional regulator
H9L23_RS23465	COG1131	(ABC) transporter
H9L23_RS23475	COG0667	Aldo Keto reductase
H9L23_RS23480	COG1902	pentaerythritol trinitrate reductase activity
H9L23_RS23530	COG0714	Associated with various cellular activities
H9L23_RS23575	COG0321	lipoyl(octanoyl) transferase activity
H9L23_RS23600	COG1028	Short-chain dehydrogenase reductase Sdr
H9L23_RS23605	COG0151	Belongs to the GarS family
H9L23_RS23610	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H9L23_RS23615	COG0010	Belongs to the arginase family
H9L23_RS23620	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H9L23_RS23630	COG0038	chloride channel
H9L23_RS23635	COG3483	tryptophan 2,3-dioxygenase activity
H9L23_RS23650	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
H9L23_RS23655	COG1530	ribonuclease E activity
H9L23_RS23665	COG0776	regulation of translation
H9L23_RS23685	COG0297	glycogen (starch) synthase activity
H9L23_RS23690	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H9L23_RS23695	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
H9L23_RS23710	COG2207	Transcriptional regulator
H9L23_RS23715	COG1960	acyl-CoA dehydrogenase activity
H9L23_RS23730	COG0779	Required for maturation of 30S ribosomal subunits
H9L23_RS23735	COG0195	Participates in both transcription termination and antitermination
H9L23_RS23740	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H9L23_RS23740	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H9L23_RS23775	COG1132	(ABC) transporter
H9L23_RS23795	COG0006	proline dipeptidase activity
H9L23_RS23805	COG0251	oxidation-reduction process
H9L23_RS23815	COG4771	TonB-dependent receptor
H9L23_RS23835	COG1132	(ABC) transporter
H9L23_RS23850	COG1228	amidohydrolase
H9L23_RS23865	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H9L23_RS23870	COG0512	Glutamine amidotransferase of anthranilate synthase
H9L23_RS23875	COG0134	indole-3-glycerol-phosphate synthase activity
H9L23_RS23880	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H9L23_RS23890	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H9L23_RS23895	COG1272	protein, Hemolysin III
H9L23_RS23915	COG1597	lipid kinase activity
H9L23_RS23950	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H9L23_RS23980	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H9L23_RS24010	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H9L23_RS24030	COG2972	Histidine kinase
H9L23_RS24045	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H9L23_RS24050	COG0019	diaminopimelate decarboxylase activity
H9L23_RS24070	COG1278	Cold shock
H9L23_RS24085	COG1053	succinate dehydrogenase
H9L23_RS24090	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H9L23_RS24120	COG4585	Histidine kinase
H9L23_RS24135	COG2197	response regulator
H9L23_RS24165	COG3279	Response regulator of the LytR AlgR family
H9L23_RS24175	COG0494	nUDIX hydrolase
H9L23_RS24185	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H9L23_RS24200	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H9L23_RS24225	COG1741	Belongs to the pirin family
H9L23_RS24230	COG1902	pentaerythritol trinitrate reductase activity
H9L23_RS24235	COG0640	Transcriptional regulator
H9L23_RS24250	COG4771	TonB-dependent receptor
H9L23_RS24255	COG0702	epimerase
H9L23_RS24275	COG1733	regulation of RNA biosynthetic process
H9L23_RS24335	COG1940	carbohydrate kinase activity
H9L23_RS24340	COG0673	inositol 2-dehydrogenase activity
H9L23_RS24350	COG0673	inositol 2-dehydrogenase activity
H9L23_RS24360	COG2378	regulation of single-species biofilm formation
H9L23_RS24375	COG1028	Short-chain dehydrogenase reductase Sdr
H9L23_RS24400	COG1216	Glycosyl transferase, family 2
H9L23_RS24445	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H9L23_RS24450	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H9L23_RS24455	COG1160	GTP binding
H9L23_RS24465	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H9L23_RS24475	COG0076	glutamate decarboxylase activity
H9L23_RS24480	COG0793	Belongs to the peptidase S41A family
H9L23_RS24485	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
H9L23_RS24495	COG0670	Belongs to the BI1 family
H9L23_RS24505	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H9L23_RS24525	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H9L23_RS24530	COG0083	homoserine kinase activity
H9L23_RS24540	COG0527	aspartate kinase activity
H9L23_RS24540	COG0460	homoserine dehydrogenase
H9L23_RS24545	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
H9L23_RS24580	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H9L23_RS24585	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H9L23_RS24595	COG0649	NAD binding
H9L23_RS24600	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
H9L23_RS24610	COG1034	ATP synthesis coupled electron transport
H9L23_RS24615	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
H9L23_RS24620	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H9L23_RS24630	COG0713	ATP synthesis coupled electron transport
H9L23_RS24640	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H9L23_RS24645	COG1007	ATP synthesis coupled electron transport
H9L23_RS24650	COG0586	Pfam SNARE associated Golgi protein
H9L23_RS24660	COG1253	flavin adenine dinucleotide binding
H9L23_RS24665	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H9L23_RS24675	COG0511	ligase activity, forming carbon-carbon bonds
H9L23_RS24680	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H9L23_RS24690	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
H9L23_RS24710	COG2353	YceI-like domain
H9L23_RS24735	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
H9L23_RS24760	COG0346	lactoylglutathione lyase activity
H9L23_RS24770	COG1217	gtp-binding protein TYPA
H9L23_RS24780	COG2249	NAD(P)H dehydrogenase (quinone) activity
H9L23_RS24805	COG0693	protein deglycase activity
H9L23_RS24830	COG0705	Rhomboid family
H9L23_RS24850	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H9L23_RS24910	COG0653	protein targeting
H9L23_RS24930	COG1473	amidohydrolase
H9L23_RS24950	COG0358	DNA primase activity
H9L23_RS24955	COG0792	nuclease activity
H9L23_RS24985	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H9L23_RS24995	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H9L23_RS25000	COG2045	Belongs to the ComB family
H9L23_RS25030	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H9L23_RS25030	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H9L23_RS25035	COG1764	response to oxidative stress
H9L23_RS25055	COG0815	Transfers the fatty acyl group on membrane lipoproteins
H9L23_RS25065	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
H9L23_RS25070	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H9L23_RS25085	COG1278	Cold shock
H9L23_RS25095	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H9L23_RS25155	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H9L23_RS25175	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H9L23_RS25190	COG0351	phosphomethylpyrimidine kinase
H9L23_RS25195	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H9L23_RS25250	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H9L23_RS25255	COG1595	DNA-templated transcription, initiation
H9L23_RS25260	COG1233	COG1233 Phytoene dehydrogenase and related
H9L23_RS25310	COG4771	TonB-dependent receptor
H9L23_RS25315	COG0702	epimerase
H9L23_RS25320	COG4242	Belongs to the peptidase S51 family
H9L23_RS25335	COG3258	Cytochrome c
H9L23_RS25350	COG2855	membrane
H9L23_RS25365	COG0640	Transcriptional regulator
H9L23_RS25380	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
H9L23_RS25410	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
H9L23_RS25420	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H9L23_RS25425	COG4771	TonB-dependent receptor
H9L23_RS25455	COG1629	transport
H9L23_RS25490	COG0300	oxidoreductase activity
H9L23_RS25495	COG2207	Transcriptional regulator
H9L23_RS25495	COG0662	Cupin 2, conserved barrel domain protein
H9L23_RS25510	COG0702	epimerase
H9L23_RS25515	COG0702	epimerase
H9L23_RS25520	COG1629	transport
H9L23_RS25525	COG0659	secondary active sulfate transmembrane transporter activity
H9L23_RS25530	COG4771	TonB-dependent receptor
H9L23_RS25550	COG4771	TonB-dependent receptor
H9L23_RS25580	COG3291	Pkd domain containing protein
H9L23_RS25605	COG0745	RESPONSE REGULATOR receiver
H9L23_RS25610	COG1609	Transcriptional regulator
H9L23_RS25615	COG4206	TonB-dependent receptor
H9L23_RS25615	COG1629	transport
H9L23_RS25630	COG0366	Alpha amylase catalytic
H9L23_RS25635	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H9L23_RS25640	COG1554	hydrolase, family 65, central catalytic
H9L23_RS25645	COG0366	Alpha amylase catalytic
H9L23_RS25650	COG2211	Major facilitator Superfamily
H9L23_RS25650	COG2190	(PTS) system
H9L23_RS25700	COG0825	malonyl-CoA metabolic process
H9L23_RS25720	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H9L23_RS25725	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H9L23_RS25730	COG0193	aminoacyl-tRNA hydrolase activity
H9L23_RS25745	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H9L23_RS25760	COG0545	Peptidyl-prolyl cis-trans isomerase
H9L23_RS25765	COG0105	UTP biosynthetic process
H9L23_RS25770	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
H9L23_RS25775	COG0545	Peptidyl-prolyl cis-trans isomerase
H9L23_RS25795	COG2954	triphosphatase activity
H9L23_RS25800	COG3525	Glycosyl hydrolase, family 20, catalytic domain
H9L23_RS25810	COG1012	belongs to the aldehyde dehydrogenase family
H9L23_RS25815	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
H9L23_RS25830	COG0531	amino acid
H9L23_RS25835	COG4682	membrane
H9L23_RS25840	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H9L23_RS25840	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H9L23_RS25855	COG1595	DNA-templated transcription, initiation
H9L23_RS25865	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H9L23_RS25875	COG0215	cysteine-tRNA ligase activity
H9L23_RS25880	COG1794	racemase activity, acting on amino acids and derivatives
H9L23_RS25895	COG0484	heat shock protein binding
H9L23_RS25900	COG0438	transferase activity, transferring glycosyl groups
H9L23_RS25910	COG0037	tRNA processing
H9L23_RS25920	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H9L23_RS25940	COG0714	Associated with various cellular activities
H9L23_RS25965	COG0584	glycerophosphoryl diester phosphodiesterase
H9L23_RS25975	COG2234	aminopeptidase activity
H9L23_RS25990	COG2706	6-phosphogluconolactonase activity
H9L23_RS25995	COG1187	pseudouridine synthase activity
H9L23_RS26005	COG0633	Ferredoxin
H9L23_RS26015	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H9L23_RS26020	COG0084	hydrolase, TatD family'
H9L23_RS26025	COG0252	asparaginase activity
H9L23_RS26035	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H9L23_RS26035	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H9L23_RS26040	COG0492	ferredoxin-NADP+ reductase activity
H9L23_RS26060	COG0142	geranyltranstransferase activity
H9L23_RS26070	COG2195	Cleaves the N-terminal amino acid of tripeptides
H9L23_RS26075	COG0739	heme binding
H9L23_RS26095	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H9L23_RS26125	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H9L23_RS26155	COG2353	YceI-like domain
H9L23_RS26165	COG3119	arylsulfatase activity
H9L23_RS26170	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H9L23_RS26170	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
H9L23_RS26175	COG1137	ATPase activity
H9L23_RS26210	COG3339	Conserved Protein
H9L23_RS26240	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H9L23_RS26255	COG0601	transmembrane transport
H9L23_RS26260	COG2318	DinB family
H9L23_RS26265	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H9L23_RS26270	COG1233	COG1233 Phytoene dehydrogenase and related
H9L23_RS26295	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H9L23_RS26310	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
H9L23_RS26320	COG1216	Glycosyl transferase, family 2
H9L23_RS26340	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H9L23_RS26350	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H9L23_RS26355	COG3265	gluconokinase activity