locus-tag	class	description
PPRO_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
PPRO_RS00010	COG0592	DNA-directed DNA polymerase activity
PPRO_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
PPRO_RS00035	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
PPRO_RS00050	COG1322	Protein conserved in bacteria
PPRO_RS00055	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
PPRO_RS00060	COG0484	heat shock protein binding
PPRO_RS00085	COG0483	inositol monophosphate 1-phosphatase activity
PPRO_RS00105	COG1872	DUF167
PPRO_RS00110	COG0545	Peptidyl-prolyl cis-trans isomerase
PPRO_RS00140	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
PPRO_RS00145	COG2204	response regulator
PPRO_RS00150	COG4191	Histidine kinase
PPRO_RS00155	COG0215	cysteine-tRNA ligase activity
PPRO_RS00170	COG0511	ligase activity, forming carbon-carbon bonds
PPRO_RS00180	COG0612	Peptidase, M16
PPRO_RS00185	COG2070	2-Nitropropane dioxygenase
PPRO_RS00190	COG2226	methyltransferase
PPRO_RS00200	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
PPRO_RS00220	COG0473	3-isopropylmalate dehydrogenase activity
PPRO_RS00230	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
PPRO_RS00245	COG0367	asparagine synthase
PPRO_RS00250	COG0742	ribosomal rna small subunit methyltransferase
PPRO_RS00310	COG0175	sulfate reduction
PPRO_RS00320	COG0826	peptidase U32
PPRO_RS00345	COG0651	ATP synthesis coupled electron transport
PPRO_RS00350	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
PPRO_RS00375	COG1012	belongs to the aldehyde dehydrogenase family
PPRO_RS00385	COG0840	transmembrane signaling receptor activity
PPRO_RS00390	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
PPRO_RS00405	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
PPRO_RS00415	COG1573	uracil-dna glycosylase
PPRO_RS00425	COG3209	COG3209 Rhs family protein
PPRO_RS00440	COG2201	protein-glutamate methylesterase activity
PPRO_RS00445	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
PPRO_RS00450	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PPRO_RS00465	COG0784	Response regulator, receiver
PPRO_RS00470	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
PPRO_RS00475	COG1024	Enoyl-CoA hydratase
PPRO_RS00545	COG0667	Aldo Keto reductase
PPRO_RS00550	COG2207	Transcriptional regulator
PPRO_RS00565	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
PPRO_RS00580	COG0386	Belongs to the glutathione peroxidase family
PPRO_RS00600	COG0386	Belongs to the glutathione peroxidase family
PPRO_RS00620	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
PPRO_RS00665	COG0606	chelatase, subunit chli
PPRO_RS00675	COG3328	transposase activity
PPRO_RS00680	COG3385	transposase activity
PPRO_RS00685	COG3328	transposase activity
PPRO_RS00700	COG1309	transcriptional regulator
PPRO_RS00715	COG1136	(ABC) transporter
PPRO_RS00715	COG0577	efflux transmembrane transporter activity
PPRO_RS00845	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PPRO_RS00870	COG3089	Belongs to the UPF0270 family
PPRO_RS00875	COG1570	exodeoxyribonuclease VII activity
PPRO_RS00880	COG1722	exodeoxyribonuclease VII activity
PPRO_RS00885	COG0776	regulation of translation
PPRO_RS00915	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
PPRO_RS00930	COG2135	peptidase activity
PPRO_RS00935	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
PPRO_RS00945	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
PPRO_RS00950	COG0741	lytic transglycosylase activity
PPRO_RS01060	COG2003	Belongs to the UPF0758 family
PPRO_RS01065	COG3177	Filamentation induced by cAMP protein fic
PPRO_RS01105	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
PPRO_RS01145	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
PPRO_RS01170	COG0681	Belongs to the peptidase S26 family
PPRO_RS01350	COG0586	Pfam SNARE associated Golgi protein
PPRO_RS01355	COG0646	methionine synthase
PPRO_RS01355	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
PPRO_RS01365	COG4974	Belongs to the 'phage' integrase family
PPRO_RS01370	COG0427	acetyl-CoA hydrolase
PPRO_RS01385	COG0163	prenyltransferase activity
PPRO_RS01390	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
PPRO_RS01395	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
PPRO_RS01405	COG0297	glycogen (starch) synthase activity
PPRO_RS01410	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
PPRO_RS01420	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
PPRO_RS01430	COG0674	pyruvate-flavodoxin oxidoreductase activity
PPRO_RS01430	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
PPRO_RS01430	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
PPRO_RS01430	COG1013	pyruvate-flavodoxin oxidoreductase activity
PPRO_RS01435	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
PPRO_RS01440	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
PPRO_RS01445	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
PPRO_RS01455	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
PPRO_RS01465	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
PPRO_RS01485	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
PPRO_RS01495	COG0488	(ABC) transporter
PPRO_RS01505	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
PPRO_RS01510	COG0432	Pfam Uncharacterised protein family UPF0047
PPRO_RS01525	COG3437	response regulator, receiver
PPRO_RS01555	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
PPRO_RS01560	COG1144	Oxidoreductase
PPRO_RS01565	COG0674	pyruvate-flavodoxin oxidoreductase activity
PPRO_RS01570	COG1013	pyruvate-flavodoxin oxidoreductase activity
PPRO_RS01575	COG0778	Nitroreductase
PPRO_RS01595	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PPRO_RS01600	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PPRO_RS01605	COG1309	transcriptional regulator
PPRO_RS01615	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
PPRO_RS01630	COG0651	ATP synthesis coupled electron transport
PPRO_RS01645	COG0651	ATP synthesis coupled electron transport
PPRO_RS01650	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
PPRO_RS01650	COG3261	NADH dehydrogenase
PPRO_RS01655	COG3260	NADH ubiquinone oxidoreductase 20
PPRO_RS01690	COG0211	Belongs to the bacterial ribosomal protein bL27 family
PPRO_RS01695	COG0261	This protein binds to 23S rRNA in the presence of protein L20
PPRO_RS01730	COG0732	type I restriction modification DNA specificity domain
PPRO_RS01835	COG2197	response regulator
PPRO_RS01845	COG2204	response regulator
PPRO_RS01855	COG0204	Acyl-transferase
PPRO_RS01870	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
PPRO_RS01875	COG0488	(ABC) transporter
PPRO_RS01885	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
PPRO_RS01890	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
PPRO_RS01890	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
PPRO_RS01935	COG3604	Transcriptional regulator
PPRO_RS01950	COG2995	paraquat-inducible protein a
PPRO_RS01955	COG2995	paraquat-inducible protein a
PPRO_RS01960	COG3008	intermembrane lipid transfer
PPRO_RS01960	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
PPRO_RS01970	COG0628	permease
PPRO_RS01980	COG0366	Alpha amylase catalytic
PPRO_RS02020	COG0058	SHG alpha-glucan phosphorylase activity
PPRO_RS02030	COG3064	Membrane
PPRO_RS02050	COG4191	Histidine kinase
PPRO_RS02055	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
PPRO_RS02060	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
PPRO_RS02080	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
PPRO_RS02085	COG0820	rRNA (adenine-C2-)-methyltransferase activity
PPRO_RS02100	COG0513	Belongs to the DEAD box helicase family
PPRO_RS02105	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
PPRO_RS02125	COG2204	response regulator
PPRO_RS02130	COG0589	response to stress
PPRO_RS02135	COG5002	protein histidine kinase activity
PPRO_RS02140	COG0745	RESPONSE REGULATOR receiver
PPRO_RS02145	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
PPRO_RS02150	COG3481	metal-dependent phosphohydrolase, HD sub domain
PPRO_RS02160	COG0113	porphobilinogen synthase activity
PPRO_RS02185	COG1132	(ABC) transporter
PPRO_RS02195	COG0629	single-stranded DNA binding
PPRO_RS02210	COG0538	isocitrate dehydrogenase activity
PPRO_RS02215	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
PPRO_RS02220	COG0303	'Molybdopterin
PPRO_RS02270	COG2414	aldehyde ferredoxin oxidoreductase
PPRO_RS02275	COG1773	rubredoxin
PPRO_RS02295	COG0674	pyruvate-flavodoxin oxidoreductase activity
PPRO_RS02300	COG1144	Oxidoreductase
PPRO_RS02310	COG0318	PFAM AMP-dependent synthetase and ligase
PPRO_RS02335	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
PPRO_RS02345	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
PPRO_RS02350	COG1210	Utp--glucose-1-phosphate uridylyltransferase
PPRO_RS02360	COG0450	alkyl hydroperoxide reductase
PPRO_RS02375	COG0004	ammonium transporteR
PPRO_RS02405	COG5002	protein histidine kinase activity
PPRO_RS02405	COG5001	Diguanylate cyclase
PPRO_RS02405	COG3447	MASE1 domain protein
PPRO_RS02410	COG1238	metal cluster binding
PPRO_RS02425	COG1490	D-aminoacyl-tRNA deacylase activity
PPRO_RS02450	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
PPRO_RS02480	COG0745	RESPONSE REGULATOR receiver
PPRO_RS02485	COG5002	protein histidine kinase activity
PPRO_RS02490	COG1199	ATP-dependent helicase activity
PPRO_RS02495	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
PPRO_RS02500	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
PPRO_RS02510	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
PPRO_RS02515	COG0242	peptide deformylase activity
PPRO_RS02525	COG1418	mRNA catabolic process
PPRO_RS02540	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
PPRO_RS02545	COG0124	histidyl-tRNA synthetase
PPRO_RS02560	COG0346	lactoylglutathione lyase activity
PPRO_RS02565	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
PPRO_RS02565	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
PPRO_RS02585	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
PPRO_RS02590	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
PPRO_RS02595	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
PPRO_RS02595	COG0758	DNA mediated transformation
PPRO_RS02610	COG0826	peptidase U32
PPRO_RS02615	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
PPRO_RS02620	COG0305	Participates in initiation and elongation during chromosome replication
PPRO_RS02635	COG0315	cyclic pyranopterin monophosphate synthase activity
PPRO_RS02640	COG0521	Mo-molybdopterin cofactor biosynthetic process
PPRO_RS02660	COG3706	GGDEF domain
PPRO_RS02680	COG1301	dicarboxylic acid transport
PPRO_RS02690	COG1013	pyruvate-flavodoxin oxidoreductase activity
PPRO_RS02695	COG0674	pyruvate-flavodoxin oxidoreductase activity
PPRO_RS02695	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
PPRO_RS02700	COG1027	Aspartate ammonia-lyase
PPRO_RS02705	COG3047	cAMP biosynthetic process
PPRO_RS02705	COG2885	chlorophyll binding
PPRO_RS02710	COG1454	alcohol dehydrogenase
PPRO_RS02715	COG1032	radical SAM domain protein
PPRO_RS02725	COG2854	intermembrane phospholipid transfer
PPRO_RS02740	COG1127	ABC transporter
PPRO_RS02745	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
PPRO_RS02755	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
PPRO_RS02765	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
PPRO_RS02780	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PPRO_RS02785	COG3034	peptidoglycan biosynthetic process
PPRO_RS02795	COG1376	ErfK ybiS ycfS ynhG family protein
PPRO_RS02795	COG1388	LysM domain
PPRO_RS02825	COG0180	Tryptophanyl-tRNA synthetase
PPRO_RS02830	COG2414	aldehyde ferredoxin oxidoreductase
PPRO_RS02835	COG3604	Transcriptional regulator
PPRO_RS02840	COG1192	Involved in chromosome partitioning
PPRO_RS02845	COG1475	DNA binding
PPRO_RS02850	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
PPRO_RS02850	COG2111	Na H antiporter
PPRO_RS02855	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
PPRO_RS02855	COG2111	Na H antiporter
PPRO_RS02860	COG0651	ATP synthesis coupled electron transport
PPRO_RS02880	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PPRO_RS02895	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
PPRO_RS02900	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PPRO_RS02910	COG0356	it plays a direct role in the translocation of protons across the membrane
PPRO_RS02915	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
PPRO_RS02925	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
PPRO_RS02930	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
PPRO_RS02935	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
PPRO_RS02940	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
PPRO_RS02945	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
PPRO_RS02950	COG0355	proton-transporting ATP synthase activity, rotational mechanism
PPRO_RS02955	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
PPRO_RS02960	COG1242	4 iron, 4 sulfur cluster binding
PPRO_RS02965	COG3158	transport of potassium into the cell
PPRO_RS02975	COG3830	Belongs to the UPF0237 family
PPRO_RS02980	COG2848	UPF0210 protein
PPRO_RS02985	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
PPRO_RS02995	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
PPRO_RS03005	COG0653	protein targeting
PPRO_RS03010	COG2501	S4 domain
PPRO_RS03015	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
PPRO_RS03030	COG0436	Aminotransferase
PPRO_RS03040	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
PPRO_RS03045	COG1691	(AIR) carboxylase
PPRO_RS03050	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
PPRO_RS03055	COG1058	Belongs to the CinA family
PPRO_RS03055	COG1546	Belongs to the CinA family
PPRO_RS03060	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PPRO_RS03065	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PPRO_RS03070	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PPRO_RS03075	COG0649	NAD binding
PPRO_RS03095	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
PPRO_RS03100	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PPRO_RS03110	COG0713	ATP synthesis coupled electron transport
PPRO_RS03115	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
PPRO_RS03120	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PPRO_RS03125	COG1007	ATP synthesis coupled electron transport
PPRO_RS03130	COG0574	Belongs to the PEP-utilizing enzyme family
PPRO_RS03130	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
PPRO_RS03135	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PPRO_RS03140	COG4095	Psort location CytoplasmicMembrane, score
PPRO_RS03145	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
PPRO_RS03165	COG1940	carbohydrate kinase activity
PPRO_RS03180	COG0745	RESPONSE REGULATOR receiver
PPRO_RS03195	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
PPRO_RS03200	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
PPRO_RS03215	COG1100	Small GTP-binding protein
PPRO_RS03220	COG2020	methyltransferase activity
PPRO_RS03235	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
PPRO_RS03240	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
PPRO_RS03265	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
PPRO_RS03270	COG0267	Belongs to the bacterial ribosomal protein bL33 family
PPRO_RS03280	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
PPRO_RS03290	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
PPRO_RS03295	COG0081	regulation of translation
PPRO_RS03300	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
PPRO_RS03305	COG0222	ribosome binding
PPRO_RS03310	COG0085	RNA polymerase activity
PPRO_RS03315	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
PPRO_RS03320	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
PPRO_RS03325	COG0049	tRNA binding
PPRO_RS03330	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
PPRO_RS03335	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
PPRO_RS03340	COG0051	transcription antitermination factor activity, RNA binding
PPRO_RS03345	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
PPRO_RS03350	COG0088	Forms part of the polypeptide exit tunnel
PPRO_RS03355	COG0089	rRNA binding
PPRO_RS03365	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
PPRO_RS03370	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
PPRO_RS03375	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
PPRO_RS03380	COG0255	Belongs to the universal ribosomal protein uL29 family
PPRO_RS03385	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
PPRO_RS03390	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
PPRO_RS03395	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
PPRO_RS03400	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
PPRO_RS03405	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
PPRO_RS03410	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
PPRO_RS03415	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
PPRO_RS03420	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
PPRO_RS03425	COG0200	Binds to the 23S rRNA
PPRO_RS03440	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
PPRO_RS03445	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
PPRO_RS03450	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
PPRO_RS03455	COG0202	RNA polymerase activity
PPRO_RS03460	COG0203	ribosomal protein L17
PPRO_RS03470	COG5000	phosphorelay sensor kinase activity
PPRO_RS03475	COG2204	response regulator
PPRO_RS03480	COG0134	indole-3-glycerol-phosphate synthase activity
PPRO_RS03485	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
PPRO_RS03490	COG0745	RESPONSE REGULATOR receiver
PPRO_RS03500	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
PPRO_RS03525	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PPRO_RS03560	COG0655	NAD(P)H dehydrogenase (quinone) activity
PPRO_RS03570	COG0070	glutamate synthase
PPRO_RS03570	COG0069	glutamate synthase activity
PPRO_RS03570	COG0067	glutamate synthase
PPRO_RS03575	COG0494	nUDIX hydrolase
PPRO_RS03585	COG0433	COG0433 Predicted ATPase
PPRO_RS03595	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PPRO_RS03605	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PPRO_RS03615	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
PPRO_RS03630	COG0635	Involved in the biosynthesis of porphyrin-containing compound
PPRO_RS03640	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
PPRO_RS03645	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
PPRO_RS03650	COG0193	aminoacyl-tRNA hydrolase activity
PPRO_RS03655	COG0012	GTP binding
PPRO_RS03660	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
PPRO_RS03665	COG1045	serine acetyltransferase
PPRO_RS03670	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
PPRO_RS03670	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
PPRO_RS03685	COG1278	Cold shock
PPRO_RS03695	COG0513	Belongs to the DEAD box helicase family
PPRO_RS03700	COG0653	protein targeting
PPRO_RS03705	COG1012	belongs to the aldehyde dehydrogenase family
PPRO_RS03705	COG1454	alcohol dehydrogenase
PPRO_RS03710	COG0360	Binds together with S18 to 16S ribosomal RNA
PPRO_RS03715	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
PPRO_RS03725	COG0359	binds to the 23S rRNA
PPRO_RS03730	COG1253	flavin adenine dinucleotide binding
PPRO_RS03740	COG1309	transcriptional regulator
PPRO_RS03745	COG1657	PFAM Prenyltransferase squalene oxidase
PPRO_RS03755	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PPRO_RS03760	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PPRO_RS03765	COG0438	transferase activity, transferring glycosyl groups
PPRO_RS03780	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
PPRO_RS03785	COG1321	iron dependent repressor
PPRO_RS03790	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
PPRO_RS03795	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
PPRO_RS03795	COG0778	Nitroreductase
PPRO_RS03800	COG0446	pyridine nucleotide-disulphide oxidoreductase
PPRO_RS03800	COG1902	pentaerythritol trinitrate reductase activity
PPRO_RS03830	COG0628	permease
PPRO_RS03835	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
PPRO_RS03835	COG4651	solute:proton antiporter activity
PPRO_RS03845	COG0861	Integral membrane protein TerC family
PPRO_RS03880	COG1918	ferrous iron import across plasma membrane
PPRO_RS03880	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
PPRO_RS03905	COG0716	FMN binding
PPRO_RS03920	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
PPRO_RS03990	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
PPRO_RS03995	COG1459	type II secretion system
PPRO_RS04010	COG0714	Associated with various cellular activities
PPRO_RS04025	COG0672	)-iron permease
PPRO_RS04030	COG2165	general secretion pathway protein
PPRO_RS04050	COG0741	lytic transglycosylase activity
PPRO_RS04060	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
PPRO_RS04070	COG0789	Transcriptional regulator
PPRO_RS04085	COG1993	acr, cog1993
PPRO_RS04090	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
PPRO_RS04100	COG0038	chloride channel
PPRO_RS04105	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
PPRO_RS04120	COG0798	PFAM Bile acid sodium symporter
PPRO_RS04125	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
PPRO_RS04130	COG2814	Major facilitator Superfamily
PPRO_RS04140	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
PPRO_RS04145	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
PPRO_RS04155	COG0356	it plays a direct role in the translocation of protons across the membrane
PPRO_RS04170	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
PPRO_RS04210	COG2814	Major facilitator Superfamily
PPRO_RS04215	COG1846	Transcriptional regulator
PPRO_RS04230	COG0640	Transcriptional regulator
PPRO_RS04240	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
PPRO_RS04240	COG3608	succinylglutamate desuccinylase aspartoacylase
PPRO_RS04245	COG2816	NAD+ diphosphatase activity
PPRO_RS04260	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
PPRO_RS04265	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
PPRO_RS04270	COG1492	cobalamin metabolic process
PPRO_RS04275	COG0741	lytic transglycosylase activity
PPRO_RS04290	COG2204	response regulator
PPRO_RS04295	COG0835	chemotaxis
PPRO_RS04300	COG0643	Histidine kinase
PPRO_RS04300	COG2198	Histidine kinase
PPRO_RS04300	COG0784	Response regulator, receiver
PPRO_RS04305	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
PPRO_RS04315	COG2201	protein-glutamate methylesterase activity
PPRO_RS04325	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
PPRO_RS04345	COG1058	Belongs to the CinA family
PPRO_RS04345	COG1546	Belongs to the CinA family
PPRO_RS04350	COG1454	alcohol dehydrogenase
PPRO_RS04355	COG2414	aldehyde ferredoxin oxidoreductase
PPRO_RS04365	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
PPRO_RS04375	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
PPRO_RS04430	COG2205	protein histidine kinase activity
PPRO_RS04430	COG5002	protein histidine kinase activity
PPRO_RS04430	COG0784	Response regulator, receiver
PPRO_RS04440	COG1028	Short-chain dehydrogenase reductase Sdr
PPRO_RS04450	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PPRO_RS04455	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PPRO_RS04465	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
PPRO_RS04470	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
PPRO_RS04500	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PPRO_RS04515	COG1032	radical SAM domain protein
PPRO_RS04520	COG1215	transferase activity, transferring glycosyl groups
PPRO_RS04530	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PPRO_RS04545	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PPRO_RS04570	COG0076	glutamate decarboxylase activity
PPRO_RS04600	COG4316	Uncharacterized protein conserved in bacteria (DUF2251)
PPRO_RS04635	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
PPRO_RS04665	COG2353	YceI-like domain
PPRO_RS04675	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
PPRO_RS04680	COG0436	Aminotransferase
PPRO_RS04690	COG0779	Required for maturation of 30S ribosomal subunits
PPRO_RS04695	COG0195	Participates in both transcription termination and antitermination
PPRO_RS04705	COG3266	domain, Protein
PPRO_RS04705	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
PPRO_RS04710	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
PPRO_RS04725	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
PPRO_RS04730	COG1185	polyribonucleotide nucleotidyltransferase activity
PPRO_RS04735	COG0517	IMP dehydrogenase activity
PPRO_RS04735	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
PPRO_RS04740	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
PPRO_RS04770	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
PPRO_RS04775	COG1660	Displays ATPase and GTPase activities
PPRO_RS04810	COG2204	response regulator
PPRO_RS04885	COG1331	Highly conserved protein containing a thioredoxin domain
PPRO_RS04915	COG0537	adenosine 5'-monophosphoramidase activity
PPRO_RS04985	COG0018	arginyl-trna synthetase
PPRO_RS05000	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
PPRO_RS05005	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
PPRO_RS05010	COG0022	dehydrogenase e1 component
PPRO_RS05015	COG0508	dehydrogenase complex catalyzes the overall conversion of
PPRO_RS05020	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
PPRO_RS05025	COG0022	dehydrogenase e1 component
PPRO_RS05030	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
PPRO_RS05035	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PPRO_RS05040	COG0321	lipoyl(octanoyl) transferase activity
PPRO_RS05050	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
PPRO_RS05055	COG1242	4 iron, 4 sulfur cluster binding
PPRO_RS05065	COG0596	Alpha beta hydrolase
PPRO_RS05070	COG3199	ATP-NAD kinase
PPRO_RS05075	COG3284	Transcriptional regulator
PPRO_RS05095	COG1063	alcohol dehydrogenase
PPRO_RS05105	COG0436	Aminotransferase
PPRO_RS05115	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
PPRO_RS05125	COG1606	tRNA processing
PPRO_RS05140	COG1280	lysine exporter protein (LysE YggA)
PPRO_RS05160	COG5645	(Lipo)protein
PPRO_RS05165	COG0488	(ABC) transporter
PPRO_RS05185	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
PPRO_RS05195	COG0860	N-Acetylmuramoyl-L-alanine amidase
PPRO_RS05205	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
PPRO_RS05210	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
PPRO_RS05220	COG1331	Highly conserved protein containing a thioredoxin domain
PPRO_RS05235	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
PPRO_RS05250	COG0390	transport system, permease component
PPRO_RS05255	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
PPRO_RS05260	COG0824	Thioesterase
PPRO_RS05265	COG1846	Transcriptional regulator
PPRO_RS05280	COG1509	lysine 2,3-aminomutase activity
PPRO_RS05300	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
PPRO_RS05300	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
PPRO_RS05330	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
PPRO_RS05335	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
PPRO_RS05340	COG1408	metallophosphoesterase
PPRO_RS05345	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
PPRO_RS05350	COG0335	large ribosomal subunit rRNA binding
PPRO_RS05355	COG4752	Belongs to the RNA methyltransferase TrmD family
PPRO_RS05365	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
PPRO_RS05370	COG1837	Belongs to the UPF0109 family
PPRO_RS05375	COG0228	four-way junction DNA binding
PPRO_RS05380	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
PPRO_RS05415	COG1902	pentaerythritol trinitrate reductase activity
PPRO_RS05430	COG1733	regulation of RNA biosynthetic process
PPRO_RS05435	COG0604	alcohol dehydrogenase
PPRO_RS05560	COG2033	superoxide reductase activity
PPRO_RS05570	COG0006	proline dipeptidase activity
PPRO_RS05575	COG4260	virion core protein, lumpy skin disease virus
PPRO_RS05605	COG4974	Belongs to the 'phage' integrase family
PPRO_RS05615	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
PPRO_RS05620	COG3264	Mechanosensitive ion channel
PPRO_RS05620	COG1196	nuclear chromosome segregation
PPRO_RS05625	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
PPRO_RS05635	COG1598	PFAM Uncharacterised protein family UPF0150
PPRO_RS05645	COG0514	ATP-dependent DNA helicase (RecQ)
PPRO_RS05650	COG0047	phosphoribosylformylglycinamidine synthase activity
PPRO_RS05655	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
PPRO_RS05660	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
PPRO_RS05665	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
PPRO_RS05675	COG1914	H( )-stimulated, divalent metal cation uptake system
PPRO_RS05680	COG2239	Acts as a magnesium transporter
PPRO_RS05685	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
PPRO_RS05690	COG0285	dihydrofolate synthase activity
PPRO_RS05695	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
PPRO_RS05700	COG0159	tryptophan synthase activity
PPRO_RS05720	COG1294	oxidase, subunit
PPRO_RS05725	COG1271	oxidase subunit
PPRO_RS05745	COG0557	exoribonuclease II activity
PPRO_RS05755	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
PPRO_RS05760	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
PPRO_RS05765	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
PPRO_RS05765	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
PPRO_RS05770	COG2204	response regulator
PPRO_RS05775	COG2050	protein possibly involved in aromatic compounds catabolism
PPRO_RS05800	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
PPRO_RS05805	COG0740	serine-type endopeptidase activity
PPRO_RS05810	COG0544	peptidyl-prolyl cis-trans isomerase activity
PPRO_RS05820	COG0023	Translation Initiation Factor
PPRO_RS05825	COG0792	nuclease activity
PPRO_RS05830	COG0546	phosphoglycolate phosphatase activity
PPRO_RS05835	COG1534	Rna-binding protein
PPRO_RS05840	COG1657	PFAM Prenyltransferase squalene oxidase
PPRO_RS05845	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PPRO_RS05850	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
PPRO_RS05855	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
PPRO_RS05890	COG2188	Transcriptional regulator
PPRO_RS05895	COG0730	response to heat
PPRO_RS05915	COG1151	hydroxylamine reductase activity
PPRO_RS05920	COG4191	Histidine kinase
PPRO_RS05955	COG4303	Ethanolamine ammonia lyase large subunit
PPRO_RS05965	COG1120	ATPase activity
PPRO_RS05975	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PPRO_RS05980	COG0714	Associated with various cellular activities
PPRO_RS06020	COG1122	ATPase activity
PPRO_RS06030	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
PPRO_RS06035	COG0310	cobalt ion transport
PPRO_RS06095	COG4774	siderophore transport
PPRO_RS06105	COG0811	peptide transport
PPRO_RS06115	COG0310	cobalt ion transport
PPRO_RS06125	COG0310	cobalt ion transport
PPRO_RS06155	COG0811	peptide transport
PPRO_RS06160	COG0848	biopolymer transport protein
PPRO_RS06175	COG0833	amino acid
PPRO_RS06180	COG4771	TonB-dependent receptor
PPRO_RS06200	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PPRO_RS06205	COG1120	ATPase activity
PPRO_RS06225	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
PPRO_RS06230	COG1131	(ABC) transporter
PPRO_RS06235	COG0842	Transport permease protein
PPRO_RS06245	COG4771	TonB-dependent receptor
PPRO_RS06275	COG1943	Transposase
PPRO_RS06330	COG1703	isobutyryl-CoA mutase activity
PPRO_RS06335	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
PPRO_RS06335	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
PPRO_RS06340	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
PPRO_RS06340	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
PPRO_RS06380	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
PPRO_RS06390	COG0280	phosphate acetyltransferase
PPRO_RS06395	COG0133	tryptophan synthase activity
PPRO_RS06400	COG0135	phosphoribosylanthranilate isomerase activity
PPRO_RS06405	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
PPRO_RS06415	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
PPRO_RS06420	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
PPRO_RS06425	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
PPRO_RS06440	COG2373	Large extracellular alpha-helical protein
PPRO_RS06450	COG2720	vancomycin resistance protein
PPRO_RS06460	COG0635	Involved in the biosynthesis of porphyrin-containing compound
PPRO_RS06510	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
PPRO_RS06515	COG0582	viral genome integration into host DNA
PPRO_RS06610	COG0582	viral genome integration into host DNA
PPRO_RS06625	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
PPRO_RS06630	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
PPRO_RS06640	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
PPRO_RS06655	COG2203	Gaf domain
PPRO_RS06655	COG4251	negative regulation of phosphorylation
PPRO_RS06655	COG5001	Diguanylate cyclase
PPRO_RS06655	COG3706	GGDEF domain
PPRO_RS06675	COG0077	Prephenate dehydratase
PPRO_RS06675	COG1605	Chorismate mutase
PPRO_RS06680	COG0287	Prephenate dehydrogenase
PPRO_RS06685	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
PPRO_RS06690	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
PPRO_RS06695	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
PPRO_RS06700	COG0539	negative regulation of cytoplasmic translation
PPRO_RS06705	COG0776	regulation of translation
PPRO_RS06740	COG4771	TonB-dependent receptor
PPRO_RS06825	COG0166	Belongs to the GPI family
PPRO_RS06835	COG0513	Belongs to the DEAD box helicase family
PPRO_RS06840	COG0326	Molecular chaperone. Has ATPase activity
PPRO_RS06845	COG1785	Belongs to the alkaline phosphatase family
PPRO_RS06860	COG0658	competence protein
PPRO_RS06860	COG2333	competence protein COMEC
PPRO_RS06865	COG3706	GGDEF domain
PPRO_RS06870	COG0124	histidyl-tRNA synthetase
PPRO_RS06880	COG4206	TonB-dependent receptor
PPRO_RS06885	COG0730	response to heat
PPRO_RS06890	COG1363	Peptidase, m42
PPRO_RS06900	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
PPRO_RS06910	COG0693	protein deglycase activity
PPRO_RS06915	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
PPRO_RS06920	COG0840	transmembrane signaling receptor activity
PPRO_RS06930	COG0789	Transcriptional regulator
PPRO_RS06960	COG4807	Protein conserved in bacteria
PPRO_RS06975	COG0484	heat shock protein binding
PPRO_RS06980	COG0443	Heat shock 70 kDa protein
PPRO_RS06985	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
PPRO_RS06990	COG1420	regulation of RNA biosynthetic process
PPRO_RS07000	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
PPRO_RS07000	COG2199	diguanylate cyclase activity
PPRO_RS07005	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
PPRO_RS07015	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
PPRO_RS07025	COG1410	methionine synthase
PPRO_RS07025	COG0646	methionine synthase
PPRO_RS07040	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PPRO_RS07045	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
PPRO_RS07060	COG1216	Glycosyl transferase, family 2
PPRO_RS07065	COG0438	transferase activity, transferring glycosyl groups
PPRO_RS07070	COG0438	transferase activity, transferring glycosyl groups
PPRO_RS07075	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
PPRO_RS07085	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PPRO_RS07115	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
PPRO_RS07185	COG2814	Major facilitator Superfamily
PPRO_RS07215	COG1349	DNA-binding transcription factor activity
PPRO_RS07230	COG0303	'Molybdopterin
PPRO_RS07245	COG1032	radical SAM domain protein
PPRO_RS07255	COG4149	molybdate abc transporter
PPRO_RS07260	COG0725	ABC transporter, periplasmic molybdate-binding protein
PPRO_RS07280	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PPRO_RS07285	COG1120	ATPase activity
PPRO_RS07295	COG0811	peptide transport
PPRO_RS07300	COG0848	biopolymer transport protein
PPRO_RS07310	COG2226	methyltransferase
PPRO_RS07375	COG4206	TonB-dependent receptor
PPRO_RS07415	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
PPRO_RS07430	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
PPRO_RS07440	COG1027	Aspartate ammonia-lyase
PPRO_RS07445	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
PPRO_RS07450	COG3279	Response regulator of the LytR AlgR family
PPRO_RS07460	COG0356	it plays a direct role in the translocation of protons across the membrane
PPRO_RS07465	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
PPRO_RS07470	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
PPRO_RS07475	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
PPRO_RS07480	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
PPRO_RS07485	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
PPRO_RS07490	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
PPRO_RS07495	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
PPRO_RS07500	COG0355	proton-transporting ATP synthase activity, rotational mechanism
PPRO_RS07535	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PPRO_RS07540	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
PPRO_RS07550	COG1028	Short-chain dehydrogenase reductase Sdr
PPRO_RS07555	COG1529	Aldehyde oxidase and xanthine dehydrogenase
PPRO_RS07560	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
PPRO_RS07575	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PPRO_RS07590	COG1366	Belongs to the anti-sigma-factor antagonist family
PPRO_RS07595	COG2770	Histidine kinase
PPRO_RS07595	COG2208	phosphoserine phosphatase activity
PPRO_RS07620	COG0528	UMP kinase activity
PPRO_RS07640	COG0247	lactate metabolic process
PPRO_RS07650	COG2920	part of a sulfur-relay system
PPRO_RS07665	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
PPRO_RS07670	COG1122	ATPase activity
PPRO_RS07675	COG4206	TonB-dependent receptor
PPRO_RS07690	COG0588	phosphoglycerate mutase activity
PPRO_RS07695	COG2068	MobA-Related Protein
PPRO_RS07710	COG2226	methyltransferase
PPRO_RS07750	COG3284	Transcriptional regulator
PPRO_RS07775	COG0697	spore germination
PPRO_RS07795	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
PPRO_RS07800	COG3148	PFAM DTW domain containing protein
PPRO_RS07830	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
PPRO_RS07840	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
PPRO_RS07860	COG0497	DNA recombination
PPRO_RS07865	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
PPRO_RS07870	COG0525	valine-tRNA ligase activity
PPRO_RS07875	COG0512	Glutamine amidotransferase of anthranilate synthase
PPRO_RS07880	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
PPRO_RS07885	COG0835	chemotaxis
PPRO_RS07885	COG0784	Response regulator, receiver
PPRO_RS07890	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
PPRO_RS07900	COG0404	The glycine cleavage system catalyzes the degradation of glycine
PPRO_RS07945	COG0307	riboflavin synthase, alpha
PPRO_RS07955	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
PPRO_RS07960	COG2131	deaminase
PPRO_RS07970	COG0835	chemotaxis
PPRO_RS08005	COG0643	Histidine kinase
PPRO_RS08005	COG2198	Histidine kinase
PPRO_RS08010	COG0840	transmembrane signaling receptor activity
PPRO_RS08015	COG0835	chemotaxis
PPRO_RS08025	COG2201	protein-glutamate methylesterase activity
PPRO_RS08030	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
PPRO_RS08035	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
PPRO_RS08040	COG0504	CTP synthase activity
PPRO_RS08045	COG2877	3-deoxy-8-phosphooctulonate synthase activity
PPRO_RS08050	COG0668	transmembrane transport
PPRO_RS08060	COG0617	tRNA 3'-terminal CCA addition
PPRO_RS08065	COG0330	HflC and HflK could
PPRO_RS08080	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PPRO_RS08085	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PPRO_RS08090	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PPRO_RS08095	COG0649	NAD binding
PPRO_RS08115	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
PPRO_RS08120	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PPRO_RS08130	COG0713	ATP synthesis coupled electron transport
PPRO_RS08135	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
PPRO_RS08140	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PPRO_RS08145	COG1007	ATP synthesis coupled electron transport
PPRO_RS08155	COG0795	lipopolysaccharide-transporting ATPase activity
PPRO_RS08220	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
PPRO_RS08225	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
PPRO_RS08225	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
PPRO_RS08230	COG0148	phosphopyruvate hydratase activity
PPRO_RS08235	COG2204	response regulator
PPRO_RS08240	COG4968	Prepilin-type N-terminal cleavage methylation domain
PPRO_RS08260	COG1131	(ABC) transporter
PPRO_RS08265	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PPRO_RS08265	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PPRO_RS08270	COG1774	PSP1 C-terminal conserved region
PPRO_RS08280	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
PPRO_RS08295	COG0288	reversible hydration of carbon dioxide
PPRO_RS08300	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
PPRO_RS08335	COG0284	orotidine-5'-phosphate decarboxylase activity
PPRO_RS08340	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PPRO_RS08345	COG0739	heme binding
PPRO_RS08395	COG0668	transmembrane transport
PPRO_RS08400	COG2183	response to ionizing radiation
PPRO_RS08405	COG1994	Peptidase M50
PPRO_RS08410	COG0180	Tryptophanyl-tRNA synthetase
PPRO_RS08415	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
PPRO_RS08420	COG1970	mechanosensitive ion channel activity
PPRO_RS08425	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
PPRO_RS08435	COG1049	propionate catabolic process, 2-methylcitrate cycle
PPRO_RS08445	COG0126	phosphoglycerate kinase activity
PPRO_RS08450	COG0149	triose-phosphate isomerase activity
PPRO_RS08465	COG1528	Iron-storage protein
PPRO_RS08470	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
PPRO_RS08475	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PPRO_RS08485	COG0585	pseudouridine synthase activity
PPRO_RS08490	COG0084	hydrolase, TatD family'
PPRO_RS08505	COG1550	Protein conserved in bacteria
PPRO_RS08510	COG0017	Asparaginyl-tRNA synthetase
PPRO_RS08515	COG0709	Synthesizes selenophosphate from selenide and ATP
PPRO_RS08540	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
PPRO_RS08550	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
PPRO_RS08555	COG0045	succinate-CoA ligase (ADP-forming) activity
PPRO_RS08560	COG1214	PFAM Peptidase M22, glycoprotease
PPRO_RS08570	COG2718	Belongs to the UPF0229 family
PPRO_RS08575	COG2719	SpoVR family
PPRO_RS08590	COG1011	Hydrolase
PPRO_RS08595	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
PPRO_RS08600	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PPRO_RS08605	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
PPRO_RS08610	COG1160	GTP binding
PPRO_RS08620	COG0643	Histidine kinase
PPRO_RS08620	COG2198	Histidine kinase
PPRO_RS08625	COG0835	chemotaxis
PPRO_RS08630	COG0495	leucyl-tRNA aminoacylation
PPRO_RS08650	COG0077	Prephenate dehydratase
PPRO_RS08650	COG1605	Chorismate mutase
PPRO_RS08655	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
PPRO_RS08660	COG0542	response to heat
PPRO_RS08665	COG1640	4-alpha-glucanotransferase
PPRO_RS08675	COG0333	Belongs to the bacterial ribosomal protein bL32 family
PPRO_RS08680	COG0416	fatty acid biosynthetic process
PPRO_RS08685	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
PPRO_RS08690	COG1028	Short-chain dehydrogenase reductase Sdr
PPRO_RS08695	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PPRO_RS08700	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PPRO_RS08705	COG0698	ribose 5-phosphate isomerase
PPRO_RS08710	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
PPRO_RS08715	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
PPRO_RS08725	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
PPRO_RS08735	COG0442	prolyl-tRNA aminoacylation
PPRO_RS08740	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
PPRO_RS08775	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
PPRO_RS08780	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
PPRO_RS08790	COG1509	lysine 2,3-aminomutase activity
PPRO_RS08805	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
PPRO_RS08810	COG0741	lytic transglycosylase activity
PPRO_RS08825	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
PPRO_RS08830	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
PPRO_RS08835	COG0268	Binds directly to 16S ribosomal RNA
PPRO_RS08845	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
PPRO_RS08850	COG1242	4 iron, 4 sulfur cluster binding
PPRO_RS08855	COG0571	ribonuclease III activity
PPRO_RS08860	COG0248	Ppx GppA phosphatase
PPRO_RS08870	COG0776	regulation of translation
PPRO_RS08880	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
PPRO_RS08895	COG0720	synthase
PPRO_RS08910	COG0009	L-threonylcarbamoyladenylate synthase
PPRO_RS08915	COG3030	protein affecting phage T7 exclusion by the F plasmid
PPRO_RS08920	COG2824	Alkylphosphonate utilization operon protein PhnA
PPRO_RS08925	COG0733	neurotransmitter:sodium symporter activity
PPRO_RS08935	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
PPRO_RS08940	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
PPRO_RS08940	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
PPRO_RS08950	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
PPRO_RS08955	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
PPRO_RS08960	COG1862	Preprotein translocase
PPRO_RS08965	COG0343	queuine tRNA-ribosyltransferase activity
PPRO_RS08970	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
PPRO_RS08975	COG2385	sporulation resulting in formation of a cellular spore
PPRO_RS08990	COG0310	cobalt ion transport
PPRO_RS08995	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
PPRO_RS09000	COG1122	ATPase activity
PPRO_RS09015	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PPRO_RS09075	COG0464	growth
PPRO_RS09115	COG0626	cystathionine gamma-synthase activity
PPRO_RS09120	COG0626	cystathionine gamma-synthase activity
PPRO_RS09125	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
PPRO_RS09130	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
PPRO_RS09135	COG3706	GGDEF domain
PPRO_RS09150	COG0482	sulfurtransferase activity
PPRO_RS09165	COG2801	Transposase and inactivated derivatives
PPRO_RS09165	COG3415	Transposase
PPRO_RS09175	COG0564	pseudouridine synthase activity
PPRO_RS09190	COG1199	ATP-dependent helicase activity
PPRO_RS09215	COG0469	pyruvate kinase activity
PPRO_RS09225	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
PPRO_RS09245	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
PPRO_RS09255	COG0778	Nitroreductase
PPRO_RS09260	COG4221	oxidoreductase activity
PPRO_RS09275	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
PPRO_RS09280	COG0653	protein targeting
PPRO_RS09285	COG2135	peptidase activity
PPRO_RS09290	COG1335	isochorismatase
PPRO_RS09300	COG1570	exodeoxyribonuclease VII activity
PPRO_RS09315	COG0776	regulation of translation
PPRO_RS09325	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
PPRO_RS09335	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
PPRO_RS09340	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
PPRO_RS09345	COG2205	protein histidine kinase activity
PPRO_RS09345	COG2198	Histidine kinase
PPRO_RS09345	COG0784	Response regulator, receiver
PPRO_RS09370	COG2003	Belongs to the UPF0758 family
PPRO_RS09395	COG0776	regulation of translation
PPRO_RS09430	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
PPRO_RS09445	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
PPRO_RS09495	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
PPRO_RS09510	COG0577	efflux transmembrane transporter activity
PPRO_RS09510	COG1136	(ABC) transporter
PPRO_RS09520	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PPRO_RS09525	COG1309	transcriptional regulator
PPRO_RS09545	COG1454	alcohol dehydrogenase
PPRO_RS09545	COG1012	belongs to the aldehyde dehydrogenase family
PPRO_RS09555	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
PPRO_RS09565	COG0822	iron-sulfur transferase activity
PPRO_RS09570	COG0489	protein tyrosine kinase activity
PPRO_RS09585	COG0753	catalase activity
PPRO_RS09605	COG2226	methyltransferase
PPRO_RS09655	COG0489	protein tyrosine kinase activity
PPRO_RS09660	COG0822	iron-sulfur transferase activity
PPRO_RS09685	COG1234	tRNA 3'-trailer cleavage
PPRO_RS09695	COG0489	protein tyrosine kinase activity
PPRO_RS09715	COG1131	(ABC) transporter
PPRO_RS09735	COG0731	radical SAM domain protein
PPRO_RS09735	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
PPRO_RS09750	COG1592	Rubrerythrin
PPRO_RS09810	COG2391	methyltransferase activity
PPRO_RS09820	COG0590	tRNA wobble adenosine to inosine editing
PPRO_RS09840	COG1136	(ABC) transporter
PPRO_RS09850	COG0577	efflux transmembrane transporter activity
PPRO_RS09865	COG2133	pyrroloquinoline quinone binding
PPRO_RS09900	COG0019	diaminopimelate decarboxylase activity
PPRO_RS09905	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PPRO_RS09910	COG0778	Nitroreductase
PPRO_RS09910	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
PPRO_RS09915	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
PPRO_RS09950	COG0785	Cytochrome C biogenesis protein
PPRO_RS09955	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PPRO_RS09960	COG0142	geranyltranstransferase activity
PPRO_RS09975	COG0518	GMP synthase (glutamine-hydrolyzing) activity
PPRO_RS09975	COG0519	Catalyzes the synthesis of GMP from XMP
PPRO_RS09980	COG0516	GMP reductase activity
PPRO_RS09980	COG0517	IMP dehydrogenase activity
PPRO_RS09990	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PPRO_RS09995	COG0601	transmembrane transport
PPRO_RS10010	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PPRO_RS10020	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
PPRO_RS10030	COG0509	glycine decarboxylation via glycine cleavage system
PPRO_RS10035	COG0439	Biotin carboxylase
PPRO_RS10040	COG0511	ligase activity, forming carbon-carbon bonds
PPRO_RS10045	COG0006	proline dipeptidase activity
PPRO_RS10060	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
PPRO_RS10065	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
PPRO_RS10085	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PPRO_RS10090	COG1480	7TM receptor with intracellular HD hydrolase
PPRO_RS10095	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
PPRO_RS10100	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
PPRO_RS10110	COG0815	Transfers the fatty acyl group on membrane lipoproteins
PPRO_RS10115	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
PPRO_RS10125	COG0791	NLP P60 protein
PPRO_RS10135	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
PPRO_RS10140	COG0052	Belongs to the universal ribosomal protein uS2 family
PPRO_RS10145	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
PPRO_RS10150	COG0528	UMP kinase activity
PPRO_RS10155	COG0233	cytoplasmic translational termination
PPRO_RS10160	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
PPRO_RS10165	COG4589	Belongs to the CDS family
PPRO_RS10170	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
PPRO_RS10175	COG0750	zinc metalloprotease
PPRO_RS10215	COG2249	NAD(P)H dehydrogenase (quinone) activity
PPRO_RS10220	COG0475	glutathione-regulated potassium exporter activity
PPRO_RS10220	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
PPRO_RS10250	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
PPRO_RS10260	COG0587	DNA-directed DNA polymerase activity
PPRO_RS10265	COG0825	malonyl-CoA metabolic process
PPRO_RS10270	COG1187	pseudouridine synthase activity
PPRO_RS10280	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
PPRO_RS10290	COG1162	GTPase activity
PPRO_RS10295	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
PPRO_RS10305	COG4774	siderophore transport
PPRO_RS10320	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PPRO_RS10325	COG1120	ATPase activity
PPRO_RS10335	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
PPRO_RS10375	COG0864	Transcriptional regulator
PPRO_RS10380	COG2226	methyltransferase
PPRO_RS10385	COG2267	carboxylic ester hydrolase activity
PPRO_RS10390	COG0156	8-amino-7-oxononanoate synthase activity
PPRO_RS10395	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
PPRO_RS10395	COG0662	Cupin 2, conserved barrel domain protein
PPRO_RS10405	COG0662	Cupin 2, conserved barrel domain protein
PPRO_RS10405	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
PPRO_RS10475	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
PPRO_RS10505	COG0612	Peptidase, M16
PPRO_RS10515	COG0693	protein deglycase activity
PPRO_RS10610	COG4974	Belongs to the 'phage' integrase family
PPRO_RS10615	COG1108	ABC-type Mn2 Zn2 transport systems permease components
PPRO_RS10620	COG1121	(ABC) transporter
PPRO_RS10625	COG0803	Belongs to the bacterial solute-binding protein 9 family
PPRO_RS10625	COG3443	Belongs to the bacterial solute-binding protein 9 family
PPRO_RS10630	COG0670	Belongs to the BI1 family
PPRO_RS10650	COG0443	Heat shock 70 kDa protein
PPRO_RS10675	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
PPRO_RS10680	COG1074	ATP-dependent DNA helicase activity
PPRO_RS10685	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
PPRO_RS10710	COG1115	amino acid carrier protein
PPRO_RS10730	COG1966	Carbon starvation protein
PPRO_RS10735	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
PPRO_RS10735	COG0493	'glutamate synthase
PPRO_RS10740	COG0069	glutamate synthase activity
PPRO_RS10750	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
PPRO_RS10750	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PPRO_RS10760	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PPRO_RS10770	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
PPRO_RS10785	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
PPRO_RS10820	COG2855	membrane
PPRO_RS10825	COG0583	DNA-binding transcription factor activity
PPRO_RS10835	COG0501	Belongs to the peptidase M48B family
PPRO_RS10845	COG0444	Belongs to the ABC transporter superfamily
PPRO_RS10850	COG4608	Belongs to the ABC transporter superfamily
PPRO_RS10875	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
PPRO_RS10880	COG0742	ribosomal rna small subunit methyltransferase
PPRO_RS10900	COG1720	tRNA m6t6A37 methyltransferase activity
PPRO_RS10910	COG2084	Dehydrogenase
PPRO_RS10920	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
PPRO_RS10940	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PPRO_RS10960	COG0659	secondary active sulfate transmembrane transporter activity
PPRO_RS10990	COG0604	alcohol dehydrogenase
PPRO_RS10995	COG1309	transcriptional regulator
PPRO_RS11010	COG1538	Outer membrane efflux protein
PPRO_RS11020	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PPRO_RS11050	COG2205	protein histidine kinase activity
PPRO_RS11055	COG0745	RESPONSE REGULATOR receiver
PPRO_RS11060	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
PPRO_RS11070	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
PPRO_RS11090	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
PPRO_RS11095	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
PPRO_RS11100	COG0095	Lipoate-protein ligase
PPRO_RS11105	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
PPRO_RS11115	COG0058	SHG alpha-glucan phosphorylase activity
PPRO_RS11125	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
PPRO_RS11135	COG0598	Magnesium transport protein CorA
PPRO_RS11140	COG1950	PFAM Membrane protein of
PPRO_RS11155	COG0037	tRNA processing
PPRO_RS11160	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
PPRO_RS11165	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
PPRO_RS11170	COG0363	glucosamine-6-phosphate deaminase activity
PPRO_RS11175	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PPRO_RS11180	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
PPRO_RS11195	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PPRO_RS11200	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
PPRO_RS11205	COG0736	holo-[acyl-carrier-protein] synthase activity
PPRO_RS11210	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
PPRO_RS11210	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
PPRO_RS11215	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
PPRO_RS11215	COG0617	tRNA 3'-terminal CCA addition
PPRO_RS11215	COG0517	IMP dehydrogenase activity
PPRO_RS11220	COG0802	atpase or kinase
PPRO_RS11235	COG0590	tRNA wobble adenosine to inosine editing
PPRO_RS11295	COG2003	Belongs to the UPF0758 family
PPRO_RS11310	COG0776	regulation of translation
PPRO_RS11385	COG0582	viral genome integration into host DNA
PPRO_RS11400	COG0776	regulation of translation
PPRO_RS11405	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PPRO_RS11405	COG0072	phenylalanine-tRNA ligase activity
PPRO_RS11410	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
PPRO_RS11415	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
PPRO_RS11420	COG0291	Belongs to the bacterial ribosomal protein bL35 family
PPRO_RS11425	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
PPRO_RS11430	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
PPRO_RS11440	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
PPRO_RS11445	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
PPRO_RS11450	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
PPRO_RS11460	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
PPRO_RS11470	COG0534	Mate efflux family protein
PPRO_RS11475	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
PPRO_RS11495	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
PPRO_RS11500	COG2255	four-way junction helicase activity
PPRO_RS11505	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
PPRO_RS11515	COG1013	pyruvate-flavodoxin oxidoreductase activity
PPRO_RS11520	COG0674	pyruvate-flavodoxin oxidoreductase activity
PPRO_RS11520	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
PPRO_RS11535	COG1652	LysM domain
PPRO_RS11540	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
PPRO_RS11545	COG0681	Belongs to the peptidase S26 family
PPRO_RS11550	COG0481	GTPase activity
PPRO_RS11555	COG2271	Major facilitator Superfamily
PPRO_RS11570	COG1943	Transposase
PPRO_RS11575	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
PPRO_RS11580	COG1518	maintenance of DNA repeat elements
PPRO_RS11595	COG1857	crispr-associated protein
PPRO_RS11625	COG2176	DNA-directed DNA polymerase activity
PPRO_RS11625	COG5002	protein histidine kinase activity
PPRO_RS11630	COG1067	ATP-dependent peptidase activity
PPRO_RS11635	COG1643	Atp-dependent helicase
PPRO_RS11660	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
PPRO_RS11660	COG0778	Nitroreductase
PPRO_RS11665	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
PPRO_RS11665	COG0116	Belongs to the methyltransferase superfamily
PPRO_RS11670	COG0237	dephospho-CoA kinase activity
PPRO_RS11680	COG1472	Belongs to the glycosyl hydrolase 3 family
PPRO_RS11690	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
PPRO_RS11695	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
PPRO_RS11700	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
PPRO_RS11705	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
PPRO_RS11710	COG0784	Response regulator, receiver
PPRO_RS11710	COG0835	chemotaxis
PPRO_RS11730	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PPRO_RS11735	COG2274	protein secretion by the type I secretion system
PPRO_RS11860	COG0227	Belongs to the bacterial ribosomal protein bL28 family
PPRO_RS11875	COG1758	RNA polymerase activity
PPRO_RS11880	COG0194	GDP metabolic process
PPRO_RS11885	COG1561	YicC-like family, N-terminal region
PPRO_RS11890	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
PPRO_RS11900	COG1722	exodeoxyribonuclease VII activity
PPRO_RS11910	COG1192	Involved in chromosome partitioning
PPRO_RS11915	COG2861	carbohydrate metabolic process
PPRO_RS11920	COG0793	Belongs to the peptidase S41A family
PPRO_RS11930	COG2177	Part of the ABC transporter FtsEX involved in
PPRO_RS11935	COG2884	Cell division ATP-binding protein ftsE
PPRO_RS11975	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
PPRO_RS11980	COG1459	type II secretion system
PPRO_RS11990	COG0463	Glycosyl transferase, family 2
PPRO_RS11995	COG1584	GPR1 FUN34 yaaH family protein
PPRO_RS12010	COG0714	Associated with various cellular activities
PPRO_RS12020	COG1473	amidohydrolase
PPRO_RS12065	COG2204	response regulator
PPRO_RS12070	COG4191	Histidine kinase
PPRO_RS12075	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PPRO_RS12095	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PPRO_RS12110	COG4115	mRNA cleavage
PPRO_RS12140	COG0110	maltose O-acetyltransferase activity
PPRO_RS12180	COG0438	transferase activity, transferring glycosyl groups
PPRO_RS12195	COG0367	asparagine synthase
PPRO_RS12200	COG1215	transferase activity, transferring glycosyl groups
PPRO_RS12225	COG3267	Type II secretory pathway component ExeA
PPRO_RS12225	COG3409	Peptidoglycan-binding domain 1 protein
PPRO_RS12230	COG0489	protein tyrosine kinase activity
PPRO_RS12260	COG0635	Involved in the biosynthesis of porphyrin-containing compound
PPRO_RS12270	COG1053	succinate dehydrogenase
PPRO_RS12280	COG0343	queuine tRNA-ribosyltransferase activity
PPRO_RS12305	COG3956	TIGRFAM MazG family protein
PPRO_RS12320	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
PPRO_RS12325	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
PPRO_RS12330	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
PPRO_RS12335	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
PPRO_RS12395	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PPRO_RS12400	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
PPRO_RS12405	COG3852	Histidine kinase
PPRO_RS12410	COG1459	type II secretion system
PPRO_RS12420	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
PPRO_RS12435	COG0196	riboflavin kinase activity
PPRO_RS12440	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
PPRO_RS12455	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
PPRO_RS12465	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
PPRO_RS12470	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
PPRO_RS12485	COG0505	Belongs to the CarA family
PPRO_RS12490	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
PPRO_RS12495	COG0540	Belongs to the ATCase OTCase family
PPRO_RS12500	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
PPRO_RS12525	COG0513	Belongs to the DEAD box helicase family
PPRO_RS12540	COG0232	Belongs to the dGTPase family. Type 2 subfamily
PPRO_RS12545	COG0277	FAD linked oxidase domain protein
PPRO_RS12550	COG0247	lactate metabolic process
PPRO_RS12565	COG0772	Belongs to the SEDS family
PPRO_RS12570	COG0768	penicillin binding
PPRO_RS12580	COG1792	Involved in formation and maintenance of cell shape
PPRO_RS12585	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
PPRO_RS12590	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
PPRO_RS12595	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
PPRO_RS12600	COG0616	signal peptide processing
PPRO_RS12610	COG1183	phosphatidylcholine synthase activity
PPRO_RS12615	COG0688	phosphatidylethanolamine metabolic process
PPRO_RS12620	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
PPRO_RS12625	COG0440	acetolactate synthase activity
PPRO_RS12630	COG0440	acetolactate synthase activity
PPRO_RS12635	COG0028	Belongs to the TPP enzyme family
PPRO_RS12640	COG0129	dihydroxy-acid dehydratase activity
PPRO_RS12645	COG0028	Belongs to the TPP enzyme family
PPRO_RS12660	COG2816	NAD+ diphosphatase activity
PPRO_RS12675	COG3089	Belongs to the UPF0270 family
PPRO_RS12680	COG2195	Cleaves the N-terminal amino acid of tripeptides
PPRO_RS12685	COG0420	3'-5' exonuclease activity
PPRO_RS12690	COG0419	ATPase involved in DNA repair
PPRO_RS12715	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
PPRO_RS12725	COG1032	radical SAM domain protein
PPRO_RS12740	COG0653	protein targeting
PPRO_RS12755	COG0297	glycogen (starch) synthase activity
PPRO_RS12760	COG0463	Glycosyl transferase, family 2
PPRO_RS12770	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
PPRO_RS12775	COG1333	cytochrome c biogenesis protein
PPRO_RS12780	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
PPRO_RS12785	COG0840	transmembrane signaling receptor activity
PPRO_RS12790	COG0151	Belongs to the GarS family
PPRO_RS12795	COG0138	bifunctional purine biosynthesis protein purh
PPRO_RS12805	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
PPRO_RS12810	COG0352	thiamine-phosphate diphosphorylase activity
PPRO_RS12810	COG0351	phosphomethylpyrimidine kinase
PPRO_RS12815	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
PPRO_RS12825	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
PPRO_RS12830	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PPRO_RS12840	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
PPRO_RS12845	COG2050	protein possibly involved in aromatic compounds catabolism
PPRO_RS12850	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
PPRO_RS12860	COG1166	arginine decarboxylase activity
PPRO_RS12890	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
PPRO_RS12895	COG1132	(ABC) transporter
PPRO_RS12900	COG2205	protein histidine kinase activity
PPRO_RS12910	COG4974	Belongs to the 'phage' integrase family
PPRO_RS12930	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PPRO_RS12935	COG1592	Rubrerythrin
PPRO_RS12945	COG0534	Mate efflux family protein
PPRO_RS12960	COG0167	dihydroorotate dehydrogenase activity
PPRO_RS12965	COG0543	2 iron, 2 sulfur cluster binding
PPRO_RS12970	COG0456	acetyltransferase
PPRO_RS12985	COG1566	PFAM secretion protein HlyD family protein
PPRO_RS12990	COG2814	Major facilitator Superfamily
PPRO_RS13010	COG1388	LysM domain
PPRO_RS13010	COG0791	NLP P60 protein
PPRO_RS13015	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
PPRO_RS13020	COG2226	methyltransferase
PPRO_RS13025	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
PPRO_RS13040	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
PPRO_RS13045	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
PPRO_RS13050	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
PPRO_RS13055	COG3872	metal-dependent enzyme
PPRO_RS13060	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
PPRO_RS13065	COG0254	rRNA binding
PPRO_RS13070	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
PPRO_RS13135	COG2208	phosphoserine phosphatase activity
PPRO_RS13180	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
PPRO_RS13195	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
PPRO_RS13205	COG0632	four-way junction helicase activity
PPRO_RS13210	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
PPRO_RS13215	COG0217	transcriptional regulatory protein
PPRO_RS13235	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
PPRO_RS13240	COG0840	transmembrane signaling receptor activity
PPRO_RS13290	COG0688	phosphatidylethanolamine metabolic process
PPRO_RS13310	COG1615	UPF0182 protein
PPRO_RS13370	COG0489	protein tyrosine kinase activity
PPRO_RS13380	COG1450	Type ii and iii secretion system protein
PPRO_RS13410	COG0840	transmembrane signaling receptor activity
PPRO_RS13440	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
PPRO_RS13465	COG4191	Histidine kinase
PPRO_RS13475	COG2204	response regulator
PPRO_RS13495	COG0784	Response regulator, receiver
PPRO_RS13500	COG2202	Pas domain
PPRO_RS13500	COG2205	protein histidine kinase activity
PPRO_RS13505	COG0784	Response regulator, receiver
PPRO_RS13525	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
PPRO_RS13530	COG1040	competence protein
PPRO_RS13555	COG1063	alcohol dehydrogenase
PPRO_RS13560	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
PPRO_RS13565	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
PPRO_RS13570	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
PPRO_RS13575	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
PPRO_RS13585	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
PPRO_RS13590	COG0795	lipopolysaccharide-transporting ATPase activity
PPRO_RS13595	COG0795	lipopolysaccharide-transporting ATPase activity
PPRO_RS13625	COG1132	(ABC) transporter
PPRO_RS13660	COG1216	Glycosyl transferase, family 2
PPRO_RS13670	COG1215	transferase activity, transferring glycosyl groups
PPRO_RS13685	COG0438	transferase activity, transferring glycosyl groups
PPRO_RS13710	COG0156	8-amino-7-oxononanoate synthase activity
PPRO_RS13715	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PPRO_RS13725	COG0318	PFAM AMP-dependent synthetase and ligase
PPRO_RS13740	COG0456	acetyltransferase
PPRO_RS13745	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
PPRO_RS13750	COG1451	nucleotide metabolic process
PPRO_RS13755	COG1959	2 iron, 2 sulfur cluster binding
PPRO_RS13755	COG1295	ribonuclease BN
PPRO_RS13765	COG0409	Hydrogenase expression formation protein
PPRO_RS13770	COG0298	carbon dioxide binding
PPRO_RS13775	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
PPRO_RS13790	COG3260	NADH ubiquinone oxidoreductase 20
PPRO_RS13800	COG0650	Formate hydrogenlyase subunit 4
PPRO_RS13805	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
PPRO_RS13805	COG3261	NADH dehydrogenase
PPRO_RS13810	COG0651	ATP synthesis coupled electron transport
PPRO_RS13825	COG3383	formate dehydrogenase (NAD+) activity
PPRO_RS13830	COG3260	NADH ubiquinone oxidoreductase 20
PPRO_RS13840	COG0650	Formate hydrogenlyase subunit 4
PPRO_RS13845	COG3261	NADH dehydrogenase
PPRO_RS13845	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
PPRO_RS13850	COG0651	ATP synthesis coupled electron transport
PPRO_RS13855	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
PPRO_RS13870	COG3383	formate dehydrogenase (NAD+) activity
PPRO_RS13875	COG0737	Belongs to the 5'-nucleotidase family
PPRO_RS13885	COG0459	protein refolding
PPRO_RS13890	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
PPRO_RS13905	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
PPRO_RS13910	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
PPRO_RS13920	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
PPRO_RS13930	COG2205	protein histidine kinase activity
PPRO_RS13935	COG0745	RESPONSE REGULATOR receiver
PPRO_RS13940	COG0784	Response regulator, receiver
PPRO_RS13940	COG4191	Histidine kinase
PPRO_RS13945	COG0745	RESPONSE REGULATOR receiver
PPRO_RS13950	COG0028	Belongs to the TPP enzyme family
PPRO_RS13960	COG1403	HNH endonuclease
PPRO_RS13980	COG0426	domain, Protein
PPRO_RS14015	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
PPRO_RS14020	COG0543	2 iron, 2 sulfur cluster binding
PPRO_RS14025	COG0493	'glutamate synthase
PPRO_RS14025	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
PPRO_RS14040	COG1414	Transcriptional regulator
PPRO_RS14050	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
PPRO_RS14050	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
PPRO_RS14065	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
PPRO_RS14070	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
PPRO_RS14075	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
PPRO_RS14085	COG0573	inorganic phosphate transmembrane transporter activity
PPRO_RS14090	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
PPRO_RS14095	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
PPRO_RS14100	COG0574	Belongs to the PEP-utilizing enzyme family
PPRO_RS14100	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
PPRO_RS14170	COG0438	transferase activity, transferring glycosyl groups
PPRO_RS14220	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
PPRO_RS14230	COG0318	PFAM AMP-dependent synthetase and ligase
PPRO_RS14235	COG0367	asparagine synthase
PPRO_RS14260	COG0673	inositol 2-dehydrogenase activity
PPRO_RS14275	COG3409	Peptidoglycan-binding domain 1 protein
PPRO_RS14275	COG3267	Type II secretory pathway component ExeA
PPRO_RS14290	COG0724	RNA recognition motif
PPRO_RS14295	COG1381	Involved in DNA repair and RecF pathway recombination
PPRO_RS14300	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PPRO_RS14320	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
PPRO_RS14330	COG1797	cobyrinic acid a,c-diamide synthase activity
PPRO_RS14340	COG0220	tRNA (guanine-N7-)-methyltransferase activity
PPRO_RS14350	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
PPRO_RS14360	COG0768	penicillin binding
PPRO_RS14365	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PPRO_RS14375	COG0628	permease
PPRO_RS14380	COG2217	Heavy metal translocating P-type atpase
PPRO_RS14385	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
PPRO_RS14395	COG3132	Protein of unknown function, DUF480
PPRO_RS14405	COG1131	(ABC) transporter
PPRO_RS14410	COG0842	Transport permease protein
PPRO_RS14415	COG0842	Transport permease protein
PPRO_RS14425	COG2900	Belongs to the SlyX family
PPRO_RS14435	COG1047	Peptidyl-prolyl cis-trans
PPRO_RS14440	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
PPRO_RS14445	COG3530	Putative quorum-sensing-regulated virulence factor
PPRO_RS14455	COG1929	Belongs to the glycerate kinase type-1 family
PPRO_RS14470	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
PPRO_RS14545	COG0546	phosphoglycolate phosphatase activity
PPRO_RS14555	COG1193	negative regulation of DNA recombination
PPRO_RS14565	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
PPRO_RS14575	COG0328	RNA-DNA hybrid ribonuclease activity
PPRO_RS14585	COG1100	Small GTP-binding protein
PPRO_RS14595	COG0535	radical SAM domain protein
PPRO_RS14610	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
PPRO_RS14615	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
PPRO_RS14630	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
PPRO_RS14630	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
PPRO_RS14640	COG0564	pseudouridine synthase activity
PPRO_RS14645	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PPRO_RS14650	COG4221	oxidoreductase activity
PPRO_RS14655	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
PPRO_RS14660	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
PPRO_RS14670	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PPRO_RS14680	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
PPRO_RS14685	COG2264	protein methyltransferase activity
PPRO_RS14690	COG1385	rRNA (uridine-N3-)-methyltransferase activity
PPRO_RS14700	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
PPRO_RS14705	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
PPRO_RS14710	COG1923	regulation of RNA biosynthetic process
PPRO_RS14735	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
PPRO_RS14740	COG2186	Transcriptional regulator
PPRO_RS14745	COG0569	domain protein
PPRO_RS14760	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
PPRO_RS14765	COG0288	reversible hydration of carbon dioxide
PPRO_RS14805	COG0494	nUDIX hydrolase
PPRO_RS14810	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
PPRO_RS14810	COG0616	signal peptide processing
PPRO_RS14820	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
PPRO_RS14865	COG2314	TM2 domain
PPRO_RS14885	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
PPRO_RS14890	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
PPRO_RS14895	COG2353	YceI-like domain
PPRO_RS14905	COG2252	PERMEase
PPRO_RS14910	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
PPRO_RS14915	COG2890	protein-(glutamine-N5) methyltransferase activity
PPRO_RS14940	COG3920	Histidine kinase
PPRO_RS14945	COG0784	Response regulator, receiver
PPRO_RS14955	COG1530	ribonuclease E activity
PPRO_RS14960	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
PPRO_RS14965	COG4591	ABC-type transport system involved in lipoprotein release permease component
PPRO_RS14970	COG1136	(ABC) transporter
PPRO_RS14975	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
PPRO_RS14985	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PPRO_RS14995	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PPRO_RS15000	COG0673	inositol 2-dehydrogenase activity
PPRO_RS15010	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PPRO_RS15015	COG1132	(ABC) transporter
PPRO_RS15025	COG1519	Transferase
PPRO_RS15030	COG1663	tetraacyldisaccharide 4'-kinase activity
PPRO_RS15055	COG0438	transferase activity, transferring glycosyl groups
PPRO_RS15065	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
PPRO_RS15070	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
PPRO_RS15085	COG0131	Imidazoleglycerol-phosphate dehydratase
PPRO_RS15090	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
PPRO_RS15095	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
PPRO_RS15100	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
PPRO_RS15150	COG0358	DNA primase activity
PPRO_RS15150	COG0305	Participates in initiation and elongation during chromosome replication
PPRO_RS15160	COG0828	Belongs to the bacterial ribosomal protein bS21 family
PPRO_RS15165	COG0140	phosphoribosyl-ATP diphosphatase activity
PPRO_RS15175	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
PPRO_RS15180	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
PPRO_RS15190	COG0751	glycine-tRNA ligase activity
PPRO_RS15195	COG0752	glycyl-tRNA synthetase alpha subunit
PPRO_RS15215	COG0436	Aminotransferase
PPRO_RS15220	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
PPRO_RS15225	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PPRO_RS15230	COG1611	Belongs to the LOG family
PPRO_RS15235	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PPRO_RS15240	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
PPRO_RS15255	COG1067	ATP-dependent peptidase activity
PPRO_RS15265	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
PPRO_RS15285	COG0071	Belongs to the small heat shock protein (HSP20) family
PPRO_RS15290	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
PPRO_RS15295	COG4191	Histidine kinase
PPRO_RS15305	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
PPRO_RS15315	COG0511	ligase activity, forming carbon-carbon bonds
PPRO_RS15330	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
PPRO_RS15335	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
PPRO_RS15340	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
PPRO_RS15345	COG0154	amidase activity
PPRO_RS15350	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
PPRO_RS15355	COG2201	protein-glutamate methylesterase activity
PPRO_RS15360	COG2198	Histidine kinase
PPRO_RS15360	COG0643	Histidine kinase
PPRO_RS15365	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
PPRO_RS15370	COG1666	GTP binding
PPRO_RS15375	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
PPRO_RS15385	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
PPRO_RS15405	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
PPRO_RS15405	COG2070	2-Nitropropane dioxygenase
PPRO_RS15420	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
PPRO_RS15425	COG0596	Alpha beta hydrolase
PPRO_RS15435	COG0835	chemotaxis
PPRO_RS15440	COG0840	transmembrane signaling receptor activity
PPRO_RS15450	COG2204	response regulator
PPRO_RS15455	COG3284	Transcriptional regulator
PPRO_RS15495	COG0318	PFAM AMP-dependent synthetase and ligase
PPRO_RS15500	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PPRO_RS15520	COG3657	addiction module killer protein
PPRO_RS15565	COG3646	Phage regulatory protein
PPRO_RS15655	COG0840	transmembrane signaling receptor activity
PPRO_RS15660	COG1597	lipid kinase activity
PPRO_RS15680	COG5001	Diguanylate cyclase
PPRO_RS15680	COG3300	MHYT domain
PPRO_RS15685	COG3012	SEC-C Motif Domain Protein
PPRO_RS15700	COG0745	RESPONSE REGULATOR receiver
PPRO_RS15705	COG5002	protein histidine kinase activity
PPRO_RS15715	COG0573	inorganic phosphate transmembrane transporter activity
PPRO_RS15720	COG0573	inorganic phosphate transmembrane transporter activity
PPRO_RS15725	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
PPRO_RS15730	COG0704	Plays a role in the regulation of phosphate uptake
PPRO_RS15765	COG0165	Argininosuccinate lyase
PPRO_RS15780	COG0137	argininosuccinate synthase activity
PPRO_RS15785	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
PPRO_RS15790	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
PPRO_RS15795	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
PPRO_RS15800	COG5002	protein histidine kinase activity
PPRO_RS15805	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
PPRO_RS15810	COG2137	regulation of response to DNA damage stimulus
PPRO_RS15820	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
PPRO_RS15825	COG1007	ATP synthesis coupled electron transport
PPRO_RS15830	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PPRO_RS15835	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
PPRO_RS15840	COG0713	ATP synthesis coupled electron transport
PPRO_RS15850	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PPRO_RS15855	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
PPRO_RS15875	COG0649	NAD binding
PPRO_RS15880	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PPRO_RS15885	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PPRO_RS15890	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PPRO_RS15895	COG1376	ErfK ybiS ycfS ynhG family protein
PPRO_RS15905	COG0564	pseudouridine synthase activity
PPRO_RS15920	COG0501	Belongs to the peptidase M48B family
PPRO_RS15925	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
PPRO_RS15930	COG0702	epimerase
PPRO_RS15960	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
PPRO_RS15980	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
PPRO_RS15990	COG1127	ABC transporter
PPRO_RS16000	COG0612	Peptidase, M16
PPRO_RS16020	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
PPRO_RS16020	COG2111	Na H antiporter
PPRO_RS16025	COG2111	Na H antiporter
PPRO_RS16030	COG1006	Multisubunit Na H antiporter MnhC subunit
PPRO_RS16035	COG0651	ATP synthesis coupled electron transport
PPRO_RS16040	COG1863	multisubunit Na H antiporter MnhE subunit
PPRO_RS16045	COG2212	antiporter activity
PPRO_RS16050	COG1320	monovalent cation:proton antiporter activity
PPRO_RS16055	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PPRO_RS16065	COG1215	transferase activity, transferring glycosyl groups
PPRO_RS16075	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
PPRO_RS16100	COG1566	PFAM secretion protein HlyD family protein
PPRO_RS16105	COG1136	(ABC) transporter
PPRO_RS16110	COG1136	(ABC) transporter
PPRO_RS16110	COG0577	efflux transmembrane transporter activity
PPRO_RS16125	COG0612	Peptidase, M16
PPRO_RS16140	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
PPRO_RS16145	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
PPRO_RS16145	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
PPRO_RS16155	COG0105	UTP biosynthetic process
PPRO_RS16160	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
PPRO_RS16165	COG0668	transmembrane transport
PPRO_RS16175	COG0322	excinuclease ABC activity
PPRO_RS16180	COG0004	ammonium transporteR
PPRO_RS16200	COG0277	FAD linked oxidase domain protein
PPRO_RS16210	COG0424	maF-like protein
PPRO_RS16215	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
PPRO_RS16245	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
PPRO_RS16265	COG0729	surface antigen
PPRO_RS16290	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
PPRO_RS16295	COG1846	Transcriptional regulator
PPRO_RS16300	COG0038	chloride channel
PPRO_RS16305	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
PPRO_RS16310	COG1469	GTP cyclohydrolase I activity
PPRO_RS16315	COG0218	Necessary for normal cell division and for the maintenance of normal septation
PPRO_RS16330	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
PPRO_RS16350	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
PPRO_RS16360	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
PPRO_RS16365	COG1181	Belongs to the D-alanine--D-alanine ligase family
PPRO_RS16370	COG0812	UDP-N-acetylmuramate dehydrogenase activity
PPRO_RS16375	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
PPRO_RS16380	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
PPRO_RS16385	COG0772	Belongs to the SEDS family
PPRO_RS16390	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
PPRO_RS16395	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
PPRO_RS16400	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
PPRO_RS16405	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
PPRO_RS16410	COG0768	penicillin binding
PPRO_RS16415	COG3116	cell division
PPRO_RS16420	COG0275	rRNA processing
PPRO_RS16425	COG2001	Belongs to the MraZ family
PPRO_RS16445	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
PPRO_RS16455	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
PPRO_RS16470	COG0617	tRNA 3'-terminal CCA addition
PPRO_RS16470	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
PPRO_RS16470	COG3620	sequence-specific DNA binding
PPRO_RS16475	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
PPRO_RS16480	COG1278	Cold shock
PPRO_RS16485	COG0488	(ABC) transporter
PPRO_RS16490	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
PPRO_RS16495	COG1692	metallophosphoesterase
PPRO_RS16500	COG1418	mRNA catabolic process
PPRO_RS16505	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
PPRO_RS16520	COG0552	protein localization to endoplasmic reticulum
PPRO_RS16530	COG1196	nuclear chromosome segregation
PPRO_RS16550	COG0823	Involved in the tonB-independent uptake of proteins
PPRO_RS16565	COG0811	peptide transport
PPRO_RS16570	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PPRO_RS16580	COG0492	ferredoxin-NADP+ reductase activity
PPRO_RS16610	COG5443	negative regulation of bacterial-type flagellum assembly
PPRO_RS16645	COG0535	radical SAM domain protein
PPRO_RS16650	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
PPRO_RS16660	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
PPRO_RS16665	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PPRO_RS16690	COG2204	response regulator
PPRO_RS16695	COG4191	Histidine kinase
PPRO_RS16705	COG1193	negative regulation of DNA recombination
PPRO_RS16725	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
PPRO_RS16755	COG0204	Acyl-transferase
PPRO_RS16755	COG0318	PFAM AMP-dependent synthetase and ligase
PPRO_RS16765	COG3647	Membrane
PPRO_RS16770	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
PPRO_RS16785	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PPRO_RS16790	COG3123	guanosine phosphorylase activity
PPRO_RS16805	COG0181	hydroxymethylbilane synthase activity
PPRO_RS16810	COG1489	DNA binding
PPRO_RS16815	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
PPRO_RS16820	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
PPRO_RS16825	COG1648	precorrin-2 dehydrogenase activity
PPRO_RS16825	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
PPRO_RS16830	COG3118	belongs to the thioredoxin family
PPRO_RS16835	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PPRO_RS16840	COG0101	tRNA pseudouridine synthase activity
PPRO_RS16845	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
PPRO_RS16855	COG1086	Polysaccharide biosynthesis protein
PPRO_RS16870	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
PPRO_RS16925	COG0489	protein tyrosine kinase activity
PPRO_RS16925	COG3206	protein involved in exopolysaccharide biosynthesis
PPRO_RS16930	COG1596	polysaccharide export
PPRO_RS16935	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PPRO_RS16940	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
PPRO_RS16955	COG0402	S-adenosylhomocysteine deaminase activity
PPRO_RS16975	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
PPRO_RS16975	COG0321	lipoyl(octanoyl) transferase activity
PPRO_RS16995	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
PPRO_RS17000	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PPRO_RS17005	COG0745	RESPONSE REGULATOR receiver
PPRO_RS17025	COG1815	bacterial-type flagellum-dependent cell motility
PPRO_RS17030	COG1558	bacterial-type flagellum-dependent cell motility
PPRO_RS17035	COG1677	Flagellar hook-basal body complex protein FliE
PPRO_RS17040	COG1766	The M ring may be actively involved in energy transduction
PPRO_RS17045	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
PPRO_RS17050	COG1317	bacterial-type flagellum organization
PPRO_RS17055	COG1157	protein secretion by the type III secretion system
PPRO_RS17085	COG4786	Flagellar basal body rod
PPRO_RS17110	COG1338	Plays a role in the flagellum-specific transport system
PPRO_RS17115	COG1987	bacterial-type flagellum assembly
PPRO_RS17120	COG1684	flagellar biosynthetic protein fliR
PPRO_RS17125	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
PPRO_RS17130	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
PPRO_RS17135	COG1419	protein localization to endoplasmic reticulum
PPRO_RS17145	COG1191	sigma factor activity
PPRO_RS17150	COG4786	Flagellar basal body rod
PPRO_RS17165	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
PPRO_RS17185	COG4786	Flagellar basal body rod
PPRO_RS17185	COG1256	bacterial-type flagellum assembly
PPRO_RS17200	COG0210	DNA helicase
PPRO_RS17220	COG2201	protein-glutamate methylesterase activity
PPRO_RS17245	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
PPRO_RS17255	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
PPRO_RS17260	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
PPRO_RS17270	COG1360	Flagellar Motor Protein
PPRO_RS17285	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
PPRO_RS17295	COG2022	thiamine diphosphate biosynthetic process
PPRO_RS17300	COG0352	thiamine-phosphate diphosphorylase activity
PPRO_RS17305	COG1242	4 iron, 4 sulfur cluster binding
PPRO_RS17310	COG3437	response regulator, receiver
PPRO_RS17320	COG2204	response regulator
PPRO_RS17335	COG1022	Amp-dependent synthetase and ligase
PPRO_RS17340	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PPRO_RS17350	COG1194	a g-specific adenine glycosylase
PPRO_RS17365	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
PPRO_RS17375	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
PPRO_RS17395	COG0705	Rhomboid family
PPRO_RS17400	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PPRO_RS17405	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
PPRO_RS17415	COG0037	tRNA processing
PPRO_RS17420	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
PPRO_RS17445	COG1773	rubredoxin
PPRO_RS17445	COG1592	Rubrerythrin
PPRO_RS17450	COG1217	gtp-binding protein TYPA
PPRO_RS17460	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
PPRO_RS17470	COG0574	Belongs to the PEP-utilizing enzyme family
PPRO_RS17470	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
PPRO_RS17480	COG0242	peptide deformylase activity
PPRO_RS17485	COG3830	Belongs to the UPF0237 family
PPRO_RS17490	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
PPRO_RS17510	COG0746	molybdenum cofactor guanylyltransferase activity
PPRO_RS17515	COG3383	formate dehydrogenase (NAD+) activity
PPRO_RS17530	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
PPRO_RS17535	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
PPRO_RS17535	COG3261	NADH dehydrogenase
PPRO_RS17545	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PPRO_RS17565	COG0651	ATP synthesis coupled electron transport
PPRO_RS17570	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
PPRO_RS17570	COG2111	Na H antiporter
PPRO_RS17575	COG2111	Na H antiporter
PPRO_RS17575	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
PPRO_RS17580	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
PPRO_RS17590	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
PPRO_RS17595	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
PPRO_RS17610	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
PPRO_RS17625	COG2733	membrane
PPRO_RS17640	COG4988	ABC transporter
PPRO_RS17645	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
PPRO_RS17650	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
PPRO_RS17655	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
PPRO_RS17660	COG0488	(ABC) transporter
PPRO_RS17665	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
PPRO_RS17665	COG4651	solute:proton antiporter activity
PPRO_RS17675	COG3706	GGDEF domain
PPRO_RS17730	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
PPRO_RS17740	COG1615	UPF0182 protein
PPRO_RS17775	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
PPRO_RS17790	COG1151	hydroxylamine reductase activity
PPRO_RS17800	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
PPRO_RS17810	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PPRO_RS17820	COG2003	Belongs to the UPF0758 family
PPRO_RS17825	COG1968	undecaprenyl-diphosphatase activity
PPRO_RS17835	COG0306	phosphate transporter
PPRO_RS17850	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PPRO_RS17865	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
PPRO_RS17865	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
PPRO_RS17870	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
PPRO_RS17890	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
PPRO_RS17895	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
PPRO_RS17900	COG1674	ftsk spoiiie
PPRO_RS17920	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
PPRO_RS17935	COG0084	hydrolase, TatD family'
PPRO_RS17940	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PPRO_RS17945	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
PPRO_RS17950	COG2852	Protein conserved in bacteria
PPRO_RS17960	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
PPRO_RS17965	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
PPRO_RS17970	COG0799	negative regulation of ribosome biogenesis
PPRO_RS17975	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
PPRO_RS17980	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
PPRO_RS17990	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
PPRO_RS17995	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
PPRO_RS18005	COG0357	Ribosomal RNA small subunit methyltransferase G
PPRO_RS18010	COG0445	tRNA wobble uridine modification
PPRO_RS18015	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
PPRO_RS18020	COG0706	membrane insertase activity
PPRO_RS18040	COG0592	DNA-directed DNA polymerase activity
PPRO_RS18050	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
PPRO_RS18065	COG0187	DNA topoisomerase II activity
PPRO_RS19175	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
PPRO_RS19190	COG4251	negative regulation of phosphorylation
PPRO_RS19230	COG4191	Histidine kinase
PPRO_RS19230	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PPRO_RS19245	COG5001	Diguanylate cyclase
PPRO_RS19245	COG3300	MHYT domain
PPRO_RS19265	COG0438	transferase activity, transferring glycosyl groups
PPRO_RS19265	COG1216	Glycosyl transferase, family 2
PPRO_RS19270	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PPRO_RS19275	COG0839	Belongs to the complex I subunit 6 family
PPRO_RS19295	COG1917	Cupin 2, conserved barrel domain protein
PPRO_RS19295	COG4977	sequence-specific DNA binding
PPRO_RS19310	COG4191	Histidine kinase
PPRO_RS19310	COG0784	Response regulator, receiver
PPRO_RS19330	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
PPRO_RS19330	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
PPRO_RS19360	COG0582	viral genome integration into host DNA
PPRO_RS19395	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
PPRO_RS19405	COG4191	Histidine kinase
PPRO_RS19410	COG2198	Histidine kinase
PPRO_RS19410	COG0784	Response regulator, receiver
PPRO_RS19410	COG2205	protein histidine kinase activity
PPRO_RS19425	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
PPRO_RS19440	COG0840	transmembrane signaling receptor activity
PPRO_RS19440	COG3290	protein histidine kinase activity
PPRO_RS19450	COG0839	Belongs to the complex I subunit 6 family
PPRO_RS19455	COG3064	Membrane
PPRO_RS19465	COG3267	Type II secretory pathway component ExeA
PPRO_RS19465	COG3409	Peptidoglycan-binding domain 1 protein
PPRO_RS19485	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
PPRO_RS19510	COG4191	Histidine kinase
PPRO_RS19520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PPRO_RS19520	COG4191	Histidine kinase
PPRO_RS19540	COG3118	belongs to the thioredoxin family
PPRO_RS19540	COG0457	Tetratricopeptide repeat
PPRO_RS19595	COG0438	transferase activity, transferring glycosyl groups
PPRO_RS19635	COG3706	GGDEF domain
PPRO_RS19660	COG4251	negative regulation of phosphorylation
PPRO_RS19665	COG4251	negative regulation of phosphorylation
PPRO_RS19670	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
PPRO_RS19675	COG1620	l-lactate permease
PPRO_RS19700	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
PPRO_RS19710	COG3179	chitinase
PPRO_RS19730	COG3852	Histidine kinase
PPRO_RS19765	COG3300	MHYT domain
PPRO_RS19765	COG5001	Diguanylate cyclase
PPRO_RS19770	COG0839	Belongs to the complex I subunit 6 family
PPRO_RS19805	COG0457	Tetratricopeptide repeat
PPRO_RS19805	COG0463	Glycosyl transferase, family 2
PPRO_RS19810	COG1216	Glycosyl transferase, family 2
PPRO_RS19810	COG0463	Glycosyl transferase, family 2
PPRO_RS19815	COG3706	GGDEF domain
PPRO_RS19825	COG1215	transferase activity, transferring glycosyl groups
PPRO_RS19830	COG0438	transferase activity, transferring glycosyl groups
PPRO_RS19845	COG0556	nucleotide-excision repair
PPRO_RS19850	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PPRO_RS19850	COG0649	NAD binding
PPRO_RS19885	COG5002	protein histidine kinase activity