locus-tag	class	description
PPHA_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
PPHA_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
PPHA_RS00025	COG0426	domain, Protein
PPHA_RS00035	COG0445	tRNA wobble uridine modification
PPHA_RS00055	COG0446	pyridine nucleotide-disulphide oxidoreductase
PPHA_RS00060	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
PPHA_RS00065	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
PPHA_RS00070	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PPHA_RS00075	COG0187	DNA topoisomerase II activity
PPHA_RS00080	COG0792	nuclease activity
PPHA_RS00085	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
PPHA_RS00110	COG1530	ribonuclease E activity
PPHA_RS00120	COG0793	Belongs to the peptidase S41A family
PPHA_RS00130	COG0644	oxidoreductase
PPHA_RS00135	COG0423	glycine-tRNA ligase activity
PPHA_RS00170	COG1233	COG1233 Phytoene dehydrogenase and related
PPHA_RS00185	COG2046	Belongs to the sulfate adenylyltransferase family
PPHA_RS00195	COG2855	membrane
PPHA_RS00215	COG1619	proteins homologs of microcin C7 resistance protein MccF
PPHA_RS00220	COG0355	proton-transporting ATP synthase activity, rotational mechanism
PPHA_RS00225	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
PPHA_RS00235	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PPHA_RS00240	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
PPHA_RS00245	COG3360	Dodecin
PPHA_RS00250	COG4279	zinc finger
PPHA_RS00255	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
PPHA_RS00280	COG3012	SEC-C Motif Domain Protein
PPHA_RS00280	COG3318	Belongs to the UPF0149 family
PPHA_RS00300	COG2814	Major facilitator Superfamily
PPHA_RS00310	COG0589	response to stress
PPHA_RS00325	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PPHA_RS00345	COG0535	radical SAM domain protein
PPHA_RS00355	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
PPHA_RS00375	COG2205	protein histidine kinase activity
PPHA_RS00385	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
PPHA_RS00390	COG0750	zinc metalloprotease
PPHA_RS00395	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
PPHA_RS00405	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PPHA_RS00410	COG0284	orotidine-5'-phosphate decarboxylase activity
PPHA_RS00415	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
PPHA_RS00420	COG1090	epimerase
PPHA_RS00430	COG0004	ammonium transporteR
PPHA_RS00450	COG0802	atpase or kinase
PPHA_RS00455	COG1214	PFAM Peptidase M22, glycoprotease
PPHA_RS00475	COG0799	negative regulation of ribosome biogenesis
PPHA_RS00480	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
PPHA_RS00485	COG0504	CTP synthase activity
PPHA_RS00520	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
PPHA_RS00540	COG2154	pterin-4-alpha-carbinolamine dehydratase
PPHA_RS00580	COG0859	PFAM glycosyl transferase family 9
PPHA_RS00585	COG0360	Binds together with S18 to 16S ribosomal RNA
PPHA_RS00590	COG0629	single-stranded DNA binding
PPHA_RS00595	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
PPHA_RS00600	COG0359	binds to the 23S rRNA
PPHA_RS00620	COG0432	Pfam Uncharacterised protein family UPF0047
PPHA_RS00670	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PPHA_RS00705	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
PPHA_RS00775	COG1959	2 iron, 2 sulfur cluster binding
PPHA_RS00790	COG1151	hydroxylamine reductase activity
PPHA_RS00795	COG1487	ribonuclease activity
PPHA_RS00800	COG4456	Virulence-associated protein
PPHA_RS00810	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
PPHA_RS00880	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
PPHA_RS00885	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
PPHA_RS00890	COG0291	Belongs to the bacterial ribosomal protein bL35 family
PPHA_RS00895	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
PPHA_RS00900	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
PPHA_RS00905	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
PPHA_RS00915	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
PPHA_RS00925	COG4804	nuclease activity
PPHA_RS00975	COG1205	dead DEAH box helicase
PPHA_RS00975	COG1111	helicase
PPHA_RS01000	COG0571	ribonuclease III activity
PPHA_RS01005	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PPHA_RS01010	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PPHA_RS01015	COG1028	Short-chain dehydrogenase reductase Sdr
PPHA_RS01020	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
PPHA_RS01025	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
PPHA_RS01030	COG0416	fatty acid biosynthetic process
PPHA_RS01045	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
PPHA_RS01060	COG1108	ABC-type Mn2 Zn2 transport systems permease components
PPHA_RS01070	COG0584	glycerophosphoryl diester phosphodiesterase
PPHA_RS01080	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
PPHA_RS01085	COG3245	cytochrome
PPHA_RS01095	COG3245	cytochrome
PPHA_RS01110	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
PPHA_RS01115	COG0505	Belongs to the CarA family
PPHA_RS01120	COG1862	Preprotein translocase
PPHA_RS01125	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
PPHA_RS01135	COG0714	Associated with various cellular activities
PPHA_RS01150	COG2885	chlorophyll binding
PPHA_RS01165	COG2205	protein histidine kinase activity
PPHA_RS01195	COG0438	transferase activity, transferring glycosyl groups
PPHA_RS01230	COG2304	oxidoreductase activity
PPHA_RS01240	COG0542	response to heat
PPHA_RS01265	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
PPHA_RS01275	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
PPHA_RS01280	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
PPHA_RS01285	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
PPHA_RS01305	COG0438	transferase activity, transferring glycosyl groups
PPHA_RS01345	COG2337	Toxic component of a toxin-antitoxin (TA) module
PPHA_RS01375	COG0494	nUDIX hydrolase
PPHA_RS01415	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
PPHA_RS01440	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
PPHA_RS01445	COG0049	tRNA binding
PPHA_RS01450	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
PPHA_RS01455	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
PPHA_RS01460	COG0051	transcription antitermination factor activity, RNA binding
PPHA_RS01465	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
PPHA_RS01470	COG0088	Forms part of the polypeptide exit tunnel
PPHA_RS01475	COG0089	rRNA binding
PPHA_RS01480	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
PPHA_RS01485	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
PPHA_RS01490	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
PPHA_RS01495	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
PPHA_RS01500	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
PPHA_RS01505	COG0255	Belongs to the universal ribosomal protein uL29 family
PPHA_RS01510	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
PPHA_RS01515	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
PPHA_RS01525	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
PPHA_RS01530	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
PPHA_RS01535	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
PPHA_RS01540	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
PPHA_RS01545	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
PPHA_RS01550	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
PPHA_RS01555	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
PPHA_RS01560	COG1841	ribosomal large subunit assembly
PPHA_RS01565	COG0200	Binds to the 23S rRNA
PPHA_RS01580	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
PPHA_RS01590	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
PPHA_RS01595	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
PPHA_RS01600	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
PPHA_RS01605	COG0202	RNA polymerase activity
PPHA_RS01610	COG0203	ribosomal protein L17
PPHA_RS01615	COG0357	Ribosomal RNA small subunit methyltransferase G
PPHA_RS01620	COG0662	Cupin 2, conserved barrel domain protein
PPHA_RS01620	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
PPHA_RS01625	COG0215	cysteine-tRNA ligase activity
PPHA_RS01630	COG0218	Necessary for normal cell division and for the maintenance of normal septation
PPHA_RS01635	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
PPHA_RS01645	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
PPHA_RS01650	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
PPHA_RS01655	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
PPHA_RS01675	COG0297	glycogen (starch) synthase activity
PPHA_RS01680	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
PPHA_RS01685	COG0635	Involved in the biosynthesis of porphyrin-containing compound
PPHA_RS01695	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PPHA_RS01700	COG1940	carbohydrate kinase activity
PPHA_RS01705	COG1040	competence protein
PPHA_RS01720	COG0105	UTP biosynthetic process
PPHA_RS01735	COG2189	Belongs to the N(4) N(6)-methyltransferase family
PPHA_RS01770	COG3385	transposase activity
PPHA_RS01820	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
PPHA_RS01825	COG1104	cysteine desulfurase activity
PPHA_RS01835	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
PPHA_RS01840	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
PPHA_RS01845	COG0170	dolichyl monophosphate biosynthetic process
PPHA_RS01855	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
PPHA_RS01860	COG1215	transferase activity, transferring glycosyl groups
PPHA_RS01870	COG1278	Cold shock
PPHA_RS01910	COG1132	(ABC) transporter
PPHA_RS01945	COG0438	transferase activity, transferring glycosyl groups
PPHA_RS01955	COG4589	Belongs to the CDS family
PPHA_RS01960	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
PPHA_RS01965	COG0124	histidyl-tRNA synthetase
PPHA_RS01980	COG0779	Required for maturation of 30S ribosomal subunits
PPHA_RS01985	COG0195	Participates in both transcription termination and antitermination
PPHA_RS01990	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
PPHA_RS01990	COG3170	Tfp pilus assembly protein FimV
PPHA_RS01995	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
PPHA_RS02000	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
PPHA_RS02010	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
PPHA_RS02015	COG1561	YicC-like family, N-terminal region
PPHA_RS02020	COG0194	GDP metabolic process
PPHA_RS02035	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
PPHA_RS02040	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
PPHA_RS02055	COG0275	rRNA processing
PPHA_RS02060	COG0758	DNA mediated transformation
PPHA_RS02070	COG1304	FMN binding
PPHA_RS02105	COG1132	(ABC) transporter
PPHA_RS02115	COG0268	Binds directly to 16S ribosomal RNA
PPHA_RS02120	COG0632	four-way junction helicase activity
PPHA_RS02125	COG0285	dihydrofolate synthase activity
PPHA_RS02130	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
PPHA_RS02145	COG2086	electron transfer activity
PPHA_RS02150	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
PPHA_RS02165	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
PPHA_RS02170	COG0154	amidase activity
PPHA_RS02175	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
PPHA_RS02180	COG0517	IMP dehydrogenase activity
PPHA_RS02180	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
PPHA_RS02205	COG1595	DNA-templated transcription, initiation
PPHA_RS02210	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PPHA_RS02215	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PPHA_RS02240	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
PPHA_RS02245	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
PPHA_RS02250	COG0012	GTP binding
PPHA_RS02255	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
PPHA_RS02260	COG0539	negative regulation of cytoplasmic translation
PPHA_RS02280	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
PPHA_RS02285	COG0772	Belongs to the SEDS family
PPHA_RS02295	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
PPHA_RS02300	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
PPHA_RS02305	COG0776	regulation of translation
PPHA_RS02310	COG0730	response to heat
PPHA_RS02315	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PPHA_RS02320	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PPHA_RS02340	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
PPHA_RS02365	COG1028	Short-chain dehydrogenase reductase Sdr
PPHA_RS02370	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
PPHA_RS02375	COG4149	molybdate abc transporter
PPHA_RS02380	COG0725	ABC transporter, periplasmic molybdate-binding protein
PPHA_RS02415	COG1136	(ABC) transporter
PPHA_RS02425	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
PPHA_RS02435	COG2226	methyltransferase
PPHA_RS02440	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
PPHA_RS02460	COG1122	ATPase activity
PPHA_RS02470	COG0310	cobalt ion transport
PPHA_RS02475	COG0493	'glutamate synthase
PPHA_RS02475	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
PPHA_RS02485	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
PPHA_RS02490	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
PPHA_RS02495	COG1187	pseudouridine synthase activity
PPHA_RS02505	COG0009	L-threonylcarbamoyladenylate synthase
PPHA_RS02515	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
PPHA_RS02515	COG0248	Ppx GppA phosphatase
PPHA_RS02535	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
PPHA_RS02545	COG1196	nuclear chromosome segregation
PPHA_RS02550	COG1943	Transposase
PPHA_RS02555	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
PPHA_RS02570	COG1032	radical SAM domain protein
PPHA_RS02575	COG0514	ATP-dependent DNA helicase (RecQ)
PPHA_RS02615	COG1132	(ABC) transporter
PPHA_RS02620	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PPHA_RS02625	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
PPHA_RS02635	COG2089	acid synthase
PPHA_RS02640	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
PPHA_RS02645	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
PPHA_RS02655	COG0107	imidazoleglycerol-phosphate synthase activity
PPHA_RS02670	COG1083	cytidylyl-transferase
PPHA_RS02675	COG1028	Short-chain dehydrogenase reductase Sdr
PPHA_RS02680	COG0110	maltose O-acetyltransferase activity
PPHA_RS02750	COG0438	transferase activity, transferring glycosyl groups
PPHA_RS02775	COG1086	Polysaccharide biosynthesis protein
PPHA_RS02790	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
PPHA_RS02825	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
PPHA_RS02830	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PPHA_RS02835	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
PPHA_RS02850	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
PPHA_RS02875	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
PPHA_RS02930	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
PPHA_RS03000	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
PPHA_RS03015	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
PPHA_RS03040	COG3335	DDE superfamily endonuclease
PPHA_RS03080	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
PPHA_RS03095	COG1434	Gram-negative-bacterium-type cell wall biogenesis
PPHA_RS03105	COG2814	Major facilitator Superfamily
PPHA_RS03110	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
PPHA_RS03115	COG0574	Belongs to the PEP-utilizing enzyme family
PPHA_RS03115	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
PPHA_RS03120	COG1079	Belongs to the binding-protein-dependent transport system permease family
PPHA_RS03140	COG2274	protein secretion by the type I secretion system
PPHA_RS03145	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PPHA_RS03190	COG1663	tetraacyldisaccharide 4'-kinase activity
PPHA_RS03200	COG0151	Belongs to the GarS family
PPHA_RS03210	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
PPHA_RS03215	COG0134	indole-3-glycerol-phosphate synthase activity
PPHA_RS03220	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
PPHA_RS03225	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
PPHA_RS03235	COG0739	heme binding
PPHA_RS03240	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
PPHA_RS03240	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
PPHA_RS03245	COG1605	Chorismate mutase
PPHA_RS03245	COG0077	Prephenate dehydratase
PPHA_RS03250	COG0217	transcriptional regulatory protein
PPHA_RS03255	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
PPHA_RS03260	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
PPHA_RS03265	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
PPHA_RS03265	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
PPHA_RS03275	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
PPHA_RS03285	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PPHA_RS03290	COG0495	leucyl-tRNA aminoacylation
PPHA_RS03295	COG1185	polyribonucleotide nucleotidyltransferase activity
PPHA_RS03300	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
PPHA_RS03305	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
PPHA_RS03310	COG4608	Belongs to the ABC transporter superfamily
PPHA_RS03315	COG0616	signal peptide processing
PPHA_RS03325	COG0606	chelatase, subunit chli
PPHA_RS03365	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
PPHA_RS03370	COG3245	cytochrome
PPHA_RS03375	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
PPHA_RS03390	COG4974	Belongs to the 'phage' integrase family
PPHA_RS03400	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
PPHA_RS03410	COG0601	transmembrane transport
PPHA_RS03415	COG2255	four-way junction helicase activity
PPHA_RS03425	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
PPHA_RS03425	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
PPHA_RS03425	COG1013	pyruvate-flavodoxin oxidoreductase activity
PPHA_RS03425	COG0674	pyruvate-flavodoxin oxidoreductase activity
PPHA_RS03430	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PPHA_RS03435	COG0509	glycine decarboxylation via glycine cleavage system
PPHA_RS03440	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
PPHA_RS03445	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PPHA_RS03455	COG0497	DNA recombination
PPHA_RS03460	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
PPHA_RS03465	COG0688	phosphatidylethanolamine metabolic process
PPHA_RS03470	COG0037	tRNA processing
PPHA_RS03480	COG0328	RNA-DNA hybrid ribonuclease activity
PPHA_RS03485	COG0227	Belongs to the bacterial ribosomal protein bL28 family
PPHA_RS03490	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
PPHA_RS03495	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
PPHA_RS03500	COG0006	proline dipeptidase activity
PPHA_RS03505	COG1324	tolerance protein
PPHA_RS03530	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
PPHA_RS03535	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
PPHA_RS03550	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
PPHA_RS03560	COG0167	dihydroorotate dehydrogenase activity
PPHA_RS03580	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
PPHA_RS03585	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
PPHA_RS03585	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
PPHA_RS03590	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
PPHA_RS03595	COG0358	DNA primase activity
PPHA_RS03600	COG0811	peptide transport
PPHA_RS03610	COG0848	biopolymer transport protein
PPHA_RS03625	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
PPHA_RS03640	COG1252	NADH dehydrogenase
PPHA_RS03650	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
PPHA_RS03655	COG0635	Involved in the biosynthesis of porphyrin-containing compound
PPHA_RS03670	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
PPHA_RS03760	COG0673	inositol 2-dehydrogenase activity
PPHA_RS03770	COG0488	(ABC) transporter
PPHA_RS03785	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PPHA_RS03790	COG1136	(ABC) transporter
PPHA_RS03790	COG0577	efflux transmembrane transporter activity
PPHA_RS03815	COG0071	Belongs to the small heat shock protein (HSP20) family
PPHA_RS03825	COG0045	succinate-CoA ligase (ADP-forming) activity
PPHA_RS03830	COG0590	tRNA wobble adenosine to inosine editing
PPHA_RS03845	COG0588	phosphoglycerate mutase activity
PPHA_RS03850	COG0067	glutamate synthase
PPHA_RS03850	COG0070	glutamate synthase
PPHA_RS03850	COG0069	glutamate synthase activity
PPHA_RS03855	COG0493	'glutamate synthase
PPHA_RS03865	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
PPHA_RS03995	COG0446	pyridine nucleotide-disulphide oxidoreductase
PPHA_RS04000	COG2010	Cytochrome c
PPHA_RS04015	COG3258	Cytochrome c
PPHA_RS04035	COG1592	Rubrerythrin
PPHA_RS04045	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
PPHA_RS04050	COG4988	ABC transporter
PPHA_RS04075	COG0133	tryptophan synthase activity
PPHA_RS04090	COG1959	2 iron, 2 sulfur cluster binding
PPHA_RS04095	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
PPHA_RS04105	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
PPHA_RS04110	COG0459	protein refolding
PPHA_RS04125	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
PPHA_RS04135	COG0159	tryptophan synthase activity
PPHA_RS04170	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
PPHA_RS04175	COG0438	transferase activity, transferring glycosyl groups
PPHA_RS04180	COG1077	Cell shape determining protein MreB Mrl
PPHA_RS04185	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
PPHA_RS04190	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
PPHA_RS04195	COG1049	propionate catabolic process, 2-methylcitrate cycle
PPHA_RS04230	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
PPHA_RS04245	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
PPHA_RS04250	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
PPHA_RS04255	COG0586	Pfam SNARE associated Golgi protein
PPHA_RS04260	COG1945	arginine decarboxylase activity
PPHA_RS04265	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
PPHA_RS04270	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
PPHA_RS04275	COG0277	FAD linked oxidase domain protein
PPHA_RS04280	COG0768	penicillin binding
PPHA_RS04290	COG1792	Involved in formation and maintenance of cell shape
PPHA_RS04300	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
PPHA_RS04315	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
PPHA_RS04330	COG3772	lysozyme
PPHA_RS04355	COG0019	diaminopimelate decarboxylase activity
PPHA_RS04360	COG1945	arginine decarboxylase activity
PPHA_RS04365	COG1342	Belongs to the UPF0251 family
PPHA_RS04445	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
PPHA_RS04450	COG3657	addiction module killer protein
PPHA_RS04460	COG4942	peptidase
PPHA_RS04490	COG2884	Cell division ATP-binding protein ftsE
PPHA_RS04495	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
PPHA_RS04505	COG3301	Polysulphide reductase, NrfD
PPHA_RS04510	COG0437	4 iron, 4 sulfur cluster binding
PPHA_RS04535	COG3645	SOS response
PPHA_RS04555	COG2824	Alkylphosphonate utilization operon protein PhnA
PPHA_RS04560	COG1254	Belongs to the acylphosphatase family
PPHA_RS04570	COG1519	Transferase
PPHA_RS04590	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
PPHA_RS04600	COG4974	Belongs to the 'phage' integrase family
PPHA_RS04605	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
PPHA_RS04605	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
PPHA_RS04610	COG2873	o-acetylhomoserine
PPHA_RS04615	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
PPHA_RS04620	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
PPHA_RS04625	COG1610	YqeY-like protein
PPHA_RS04630	COG4221	oxidoreductase activity
PPHA_RS04635	COG1278	Cold shock
PPHA_RS04640	COG2003	Belongs to the UPF0758 family
PPHA_RS04665	COG1045	serine acetyltransferase
PPHA_RS04670	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
PPHA_RS04675	COG0113	porphobilinogen synthase activity
PPHA_RS04680	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
PPHA_RS04685	COG0511	ligase activity, forming carbon-carbon bonds
PPHA_RS04695	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
PPHA_RS04705	COG1587	Uroporphyrinogen-III synthase
PPHA_RS04710	COG0181	hydroxymethylbilane synthase activity
PPHA_RS04715	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
PPHA_RS04725	COG1217	gtp-binding protein TYPA
PPHA_RS04730	COG0069	glutamate synthase activity
PPHA_RS04825	COG3645	SOS response
PPHA_RS04850	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
PPHA_RS04855	COG1063	alcohol dehydrogenase
PPHA_RS04875	COG0006	proline dipeptidase activity
PPHA_RS04900	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
PPHA_RS04905	COG2814	Major facilitator Superfamily
PPHA_RS04910	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
PPHA_RS04910	COG0731	radical SAM domain protein
PPHA_RS04920	COG5002	protein histidine kinase activity
PPHA_RS04935	COG2326	polyphosphate kinase activity
PPHA_RS04945	COG0107	imidazoleglycerol-phosphate synthase activity
PPHA_RS04960	COG0438	transferase activity, transferring glycosyl groups
PPHA_RS04965	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
PPHA_RS05000	COG1442	glycosyl transferase family 8
PPHA_RS05010	COG1596	polysaccharide export
PPHA_RS05015	COG1045	serine acetyltransferase
PPHA_RS05030	COG1366	Belongs to the anti-sigma-factor antagonist family
PPHA_RS05040	COG1366	Belongs to the anti-sigma-factor antagonist family
PPHA_RS05045	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
PPHA_RS05060	COG2208	phosphoserine phosphatase activity
PPHA_RS05070	COG0492	ferredoxin-NADP+ reductase activity
PPHA_RS05075	COG1575	Belongs to the MenA family. Type 1 subfamily
PPHA_RS05090	COG2957	Belongs to the agmatine deiminase family
PPHA_RS05095	COG0039	L-malate dehydrogenase activity
PPHA_RS05100	COG0211	Belongs to the bacterial ribosomal protein bL27 family
PPHA_RS05105	COG0261	This protein binds to 23S rRNA in the presence of protein L20
PPHA_RS05115	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
PPHA_RS05120	COG1032	radical SAM domain protein
PPHA_RS05175	COG0371	Dehydrogenase
PPHA_RS05205	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
PPHA_RS05230	COG1132	(ABC) transporter
PPHA_RS05245	COG0815	Transfers the fatty acyl group on membrane lipoproteins
PPHA_RS05250	COG3829	transcription factor binding
PPHA_RS05260	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
PPHA_RS05280	COG2252	PERMEase
PPHA_RS05290	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PPHA_RS05315	COG3335	DDE superfamily endonuclease
PPHA_RS05340	COG0515	serine threonine protein kinase
PPHA_RS05340	COG2815	serine threonine protein kinase
PPHA_RS05345	COG1262	PFAM Formylglycine-generating sulfatase enzyme
PPHA_RS05360	COG0450	alkyl hydroperoxide reductase
PPHA_RS05365	COG0442	prolyl-tRNA aminoacylation
PPHA_RS05375	COG2890	protein-(glutamine-N5) methyltransferase activity
PPHA_RS05380	COG1420	regulation of RNA biosynthetic process
PPHA_RS05385	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
PPHA_RS05390	COG0484	heat shock protein binding
PPHA_RS05395	COG0281	malic enzyme
PPHA_RS05410	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
PPHA_RS05430	COG4456	Virulence-associated protein
PPHA_RS05445	COG1136	(ABC) transporter
PPHA_RS05450	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
PPHA_RS05455	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
PPHA_RS05460	COG2076	Multidrug Resistance protein
PPHA_RS05465	COG0475	glutathione-regulated potassium exporter activity
PPHA_RS05465	COG0589	response to stress
PPHA_RS05480	COG0494	nUDIX hydrolase
PPHA_RS05530	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
PPHA_RS05575	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
PPHA_RS05585	COG1192	Involved in chromosome partitioning
PPHA_RS05605	COG4804	nuclease activity
PPHA_RS05615	COG2319	Wd-40 repeat
PPHA_RS05640	COG0582	viral genome integration into host DNA
PPHA_RS05690	COG1331	Highly conserved protein containing a thioredoxin domain
PPHA_RS05695	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
PPHA_RS05695	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
PPHA_RS05700	COG0450	alkyl hydroperoxide reductase
PPHA_RS05710	COG1216	Glycosyl transferase, family 2
PPHA_RS05715	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
PPHA_RS05725	COG1280	lysine exporter protein (LysE YggA)
PPHA_RS05730	COG1686	Belongs to the peptidase S11 family
PPHA_RS05745	COG1702	phosphate starvation-inducible protein PhoH
PPHA_RS05765	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
PPHA_RS05770	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PPHA_RS05775	COG0596	Alpha beta hydrolase
PPHA_RS05780	COG0193	aminoacyl-tRNA hydrolase activity
PPHA_RS05785	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
PPHA_RS05805	COG0330	HflC and HflK could
PPHA_RS05810	COG0589	response to stress
PPHA_RS05820	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
PPHA_RS05820	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
PPHA_RS05830	COG0825	malonyl-CoA metabolic process
PPHA_RS05835	COG0346	lactoylglutathione lyase activity
PPHA_RS05845	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
PPHA_RS05850	COG3958	Transketolase
PPHA_RS05855	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
PPHA_RS05860	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
PPHA_RS05865	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PPHA_RS05865	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
PPHA_RS05910	COG0598	Magnesium transport protein CorA
PPHA_RS05925	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
PPHA_RS05935	COG3959	Transketolase, thiamine diphosphate binding domain
PPHA_RS05940	COG0742	ribosomal rna small subunit methyltransferase
PPHA_RS05945	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
PPHA_RS05950	COG0436	Aminotransferase
PPHA_RS05960	COG1774	PSP1 C-terminal conserved region
PPHA_RS05965	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PPHA_RS05965	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PPHA_RS05975	COG3876	Protein conserved in bacteria
PPHA_RS05980	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
PPHA_RS05990	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
PPHA_RS06000	COG1950	PFAM Membrane protein of
PPHA_RS06005	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
PPHA_RS06010	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
PPHA_RS06025	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
PPHA_RS06030	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
PPHA_RS06035	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
PPHA_RS06045	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
PPHA_RS06055	COG0673	inositol 2-dehydrogenase activity
PPHA_RS06065	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
PPHA_RS06080	COG0732	type I restriction modification DNA specificity domain
PPHA_RS06115	COG4804	nuclease activity
PPHA_RS06135	COG1283	sodium-dependent phosphate transmembrane transporter activity
PPHA_RS06145	COG0443	Heat shock 70 kDa protein
PPHA_RS06150	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PPHA_RS06155	COG1262	PFAM Formylglycine-generating sulfatase enzyme
PPHA_RS06225	COG4804	nuclease activity
PPHA_RS06265	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
PPHA_RS06275	COG0220	tRNA (guanine-N7-)-methyltransferase activity
PPHA_RS06280	COG4771	TonB-dependent receptor
PPHA_RS06285	COG0778	Nitroreductase
PPHA_RS06290	COG1492	cobalamin metabolic process
PPHA_RS06295	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
PPHA_RS06300	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
PPHA_RS06310	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PPHA_RS06315	COG1120	ATPase activity
PPHA_RS06365	COG1136	(ABC) transporter
PPHA_RS06375	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PPHA_RS06380	COG2081	HI0933 family
PPHA_RS06440	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
PPHA_RS06445	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
PPHA_RS06450	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
PPHA_RS06475	COG0812	UDP-N-acetylmuramate dehydrogenase activity
PPHA_RS06505	COG2048	Heterodisulfide reductase, subunit B
PPHA_RS06510	COG0436	Aminotransferase
PPHA_RS06515	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
PPHA_RS06515	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
PPHA_RS06520	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
PPHA_RS06525	COG0653	protein targeting
PPHA_RS06535	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
PPHA_RS06550	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
PPHA_RS06565	COG4191	Histidine kinase
PPHA_RS06570	COG2204	response regulator
PPHA_RS06620	COG0315	cyclic pyranopterin monophosphate synthase activity
PPHA_RS06620	COG0521	Mo-molybdopterin cofactor biosynthetic process
PPHA_RS06625	COG0303	'Molybdopterin
PPHA_RS06630	COG0746	molybdenum cofactor guanylyltransferase activity
PPHA_RS06630	COG0315	cyclic pyranopterin monophosphate synthase activity
PPHA_RS06645	COG0243	molybdopterin cofactor binding
PPHA_RS06655	COG3301	Polysulphide reductase, NrfD
PPHA_RS06665	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
PPHA_RS06680	COG1342	Belongs to the UPF0251 family
PPHA_RS06685	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
PPHA_RS06700	COG0446	pyridine nucleotide-disulphide oxidoreductase
PPHA_RS06720	COG1744	ABC transporter substrate-binding protein PnrA-like
PPHA_RS06740	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
PPHA_RS06745	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
PPHA_RS06750	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
PPHA_RS06755	COG0698	ribose 5-phosphate isomerase
PPHA_RS06765	COG1473	amidohydrolase
PPHA_RS06770	COG0191	fructose-bisphosphate aldolase activity
PPHA_RS06775	COG0793	Belongs to the peptidase S41A family
PPHA_RS06780	COG3963	phosphatidate phosphatase activity
PPHA_RS06790	COG0165	Argininosuccinate lyase
PPHA_RS06795	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
PPHA_RS06835	COG3549	Plasmid maintenance system killer
PPHA_RS06845	COG0137	argininosuccinate synthase activity
PPHA_RS06850	COG1438	arginine binding
PPHA_RS06855	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
PPHA_RS06860	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
PPHA_RS06865	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
PPHA_RS06870	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
PPHA_RS06900	COG2119	membrane
PPHA_RS06905	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
PPHA_RS06910	COG0045	succinate-CoA ligase (ADP-forming) activity
PPHA_RS06915	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
PPHA_RS06920	COG0724	RNA recognition motif
PPHA_RS06925	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
PPHA_RS07065	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
PPHA_RS07070	COG1205	dead DEAH box helicase
PPHA_RS07070	COG1111	helicase
PPHA_RS07075	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
PPHA_RS07115	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
PPHA_RS07120	COG1074	ATP-dependent DNA helicase activity
PPHA_RS07125	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
PPHA_RS07135	COG0514	ATP-dependent DNA helicase (RecQ)
PPHA_RS07140	COG0546	phosphoglycolate phosphatase activity
PPHA_RS07155	COG1598	PFAM Uncharacterised protein family UPF0150
PPHA_RS07165	COG4115	mRNA cleavage
PPHA_RS07215	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
PPHA_RS07220	COG1881	PFAM PEBP family protein
PPHA_RS07225	COG4717	serine-type aminopeptidase activity
PPHA_RS07230	COG0420	3'-5' exonuclease activity
PPHA_RS07235	COG0205	6-phosphofructokinase activity
PPHA_RS07300	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
PPHA_RS07335	COG1322	Protein conserved in bacteria
PPHA_RS07345	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
PPHA_RS07350	COG1454	alcohol dehydrogenase
PPHA_RS07370	COG1022	Amp-dependent synthetase and ligase
PPHA_RS07385	COG0335	large ribosomal subunit rRNA binding
PPHA_RS07390	COG0336	Belongs to the RNA methyltransferase TrmD family
PPHA_RS07395	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
PPHA_RS07400	COG0228	four-way junction DNA binding
PPHA_RS07405	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
PPHA_RS07410	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
PPHA_RS07410	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
PPHA_RS07425	COG0793	Belongs to the peptidase S41A family
PPHA_RS07425	COG3409	Peptidoglycan-binding domain 1 protein
PPHA_RS07435	COG0352	thiamine-phosphate diphosphorylase activity
PPHA_RS07440	COG0352	thiamine-phosphate diphosphorylase activity
PPHA_RS07445	COG0351	phosphomethylpyrimidine kinase
PPHA_RS07445	COG0352	thiamine-phosphate diphosphorylase activity
PPHA_RS07465	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
PPHA_RS07480	COG0820	rRNA (adenine-C2-)-methyltransferase activity
PPHA_RS07490	COG0563	adenylate kinase activity
PPHA_RS07495	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
PPHA_RS07505	COG0038	chloride channel
PPHA_RS07510	COG0166	Belongs to the GPI family
PPHA_RS07530	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
PPHA_RS07535	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PPHA_RS07545	COG0741	lytic transglycosylase activity
PPHA_RS07550	COG0101	tRNA pseudouridine synthase activity
PPHA_RS07555	COG0366	Alpha amylase catalytic
PPHA_RS07565	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PPHA_RS07570	COG0424	maF-like protein
PPHA_RS07580	COG3845	ABC transporter
PPHA_RS07585	COG4603	Belongs to the binding-protein-dependent transport system permease family
PPHA_RS07595	COG0515	serine threonine protein kinase
PPHA_RS07595	COG2815	serine threonine protein kinase
PPHA_RS07600	COG0142	geranyltranstransferase activity
PPHA_RS07605	COG0805	protein transport
PPHA_RS07615	COG0237	dephospho-CoA kinase activity
PPHA_RS07625	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
PPHA_RS07640	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
PPHA_RS07650	COG0492	ferredoxin-NADP+ reductase activity
PPHA_RS07655	COG3118	belongs to the thioredoxin family
PPHA_RS07660	COG3118	belongs to the thioredoxin family
PPHA_RS07680	COG1554	hydrolase, family 65, central catalytic
PPHA_RS07700	COG1262	PFAM Formylglycine-generating sulfatase enzyme
PPHA_RS07700	COG0515	serine threonine protein kinase
PPHA_RS07735	COG1262	PFAM Formylglycine-generating sulfatase enzyme
PPHA_RS07735	COG0515	serine threonine protein kinase
PPHA_RS07750	COG1262	PFAM Formylglycine-generating sulfatase enzyme
PPHA_RS07750	COG0515	serine threonine protein kinase
PPHA_RS07765	COG0511	ligase activity, forming carbon-carbon bonds
PPHA_RS07765	COG5016	pyruvate
PPHA_RS07775	COG0589	response to stress
PPHA_RS07790	COG0326	Molecular chaperone. Has ATPase activity
PPHA_RS07795	COG2089	acid synthase
PPHA_RS07815	COG1115	amino acid carrier protein
PPHA_RS07825	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
PPHA_RS07830	COG2217	Heavy metal translocating P-type atpase
PPHA_RS07845	COG2195	Cleaves the N-terminal amino acid of tripeptides
PPHA_RS07955	COG2738	Putative neutral zinc metallopeptidase
PPHA_RS07960	COG0531	amino acid
PPHA_RS07970	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
PPHA_RS07985	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
PPHA_RS07990	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
PPHA_RS08005	COG2050	protein possibly involved in aromatic compounds catabolism
PPHA_RS08010	COG1032	radical SAM domain protein
PPHA_RS08015	COG4628	conserved protein (DUF2132)
PPHA_RS08020	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
PPHA_RS08030	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
PPHA_RS08035	COG1295	ribonuclease BN
PPHA_RS08040	COG2270	Major facilitator Superfamily
PPHA_RS08045	COG0047	phosphoribosylformylglycinamidine synthase activity
PPHA_RS08050	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
PPHA_RS08055	COG1183	phosphatidylcholine synthase activity
PPHA_RS08060	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
PPHA_RS08065	COG0095	Lipoate-protein ligase
PPHA_RS08070	COG1832	CoA-binding protein
PPHA_RS08075	COG1181	Belongs to the D-alanine--D-alanine ligase family
PPHA_RS08090	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PPHA_RS08095	COG1136	(ABC) transporter
PPHA_RS08105	COG0577	efflux transmembrane transporter activity
PPHA_RS08105	COG1136	(ABC) transporter
PPHA_RS08110	COG2885	chlorophyll binding
PPHA_RS08120	COG3387	PFAM Glycoside hydrolase 15-related
PPHA_RS08125	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PPHA_RS08130	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
PPHA_RS08135	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
PPHA_RS08140	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PPHA_RS08150	COG2333	competence protein COMEC
PPHA_RS08150	COG0658	competence protein
PPHA_RS08155	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
PPHA_RS08160	COG0019	diaminopimelate decarboxylase activity
PPHA_RS08165	COG0267	Belongs to the bacterial ribosomal protein bL33 family
PPHA_RS08185	COG0277	FAD linked oxidase domain protein
PPHA_RS08235	COG1518	maintenance of DNA repeat elements
PPHA_RS08240	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
PPHA_RS08265	COG1028	Short-chain dehydrogenase reductase Sdr
PPHA_RS08280	COG1215	transferase activity, transferring glycosyl groups
PPHA_RS08310	COG0704	Plays a role in the regulation of phosphate uptake
PPHA_RS08315	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
PPHA_RS08320	COG0581	inorganic phosphate transmembrane transporter activity
PPHA_RS08325	COG0573	inorganic phosphate transmembrane transporter activity
PPHA_RS08395	COG1945	arginine decarboxylase activity
PPHA_RS08410	COG1192	Involved in chromosome partitioning
PPHA_RS08415	COG1785	Belongs to the alkaline phosphatase family
PPHA_RS08420	COG0745	RESPONSE REGULATOR receiver
PPHA_RS08425	COG5002	protein histidine kinase activity
PPHA_RS08545	COG1131	(ABC) transporter
PPHA_RS08555	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PPHA_RS08560	COG0633	Ferredoxin
PPHA_RS08570	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
PPHA_RS08575	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
PPHA_RS08580	COG1562	ergosterol biosynthetic process
PPHA_RS08585	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
PPHA_RS08595	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
PPHA_RS08655	COG2308	Evidence 4 Homologs of previously reported genes of
PPHA_RS08665	COG1305	Transglutaminase-like
PPHA_RS08675	COG1858	cytochrome C peroxidase
PPHA_RS08680	COG1858	cytochrome C peroxidase
PPHA_RS08690	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
PPHA_RS08710	COG1797	cobyrinic acid a,c-diamide synthase activity
PPHA_RS08715	COG0519	Catalyzes the synthesis of GMP from XMP
PPHA_RS08715	COG0518	GMP synthase (glutamine-hydrolyzing) activity
PPHA_RS08720	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
PPHA_RS08725	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
PPHA_RS08730	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
PPHA_RS08745	COG1522	sequence-specific DNA binding
PPHA_RS08750	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
PPHA_RS08750	COG0493	'glutamate synthase
PPHA_RS08760	COG0463	Glycosyl transferase, family 2
PPHA_RS08770	COG0756	dUTP diphosphatase activity
PPHA_RS08775	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
PPHA_RS08795	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
PPHA_RS08800	COG0149	triose-phosphate isomerase activity
PPHA_RS08810	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
PPHA_RS08815	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PPHA_RS08830	COG0681	Belongs to the peptidase S26 family
PPHA_RS08835	COG0481	GTPase activity
PPHA_RS08840	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
PPHA_RS08845	COG0242	peptide deformylase activity
PPHA_RS08870	COG0516	GMP reductase activity
PPHA_RS08890	COG1429	ligase activity, forming nitrogen-metal bonds
PPHA_RS08895	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
PPHA_RS08895	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
PPHA_RS08900	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
PPHA_RS08905	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PPHA_RS08910	COG0564	pseudouridine synthase activity
PPHA_RS08920	COG2204	response regulator
PPHA_RS08970	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PPHA_RS09035	COG0488	(ABC) transporter
PPHA_RS09095	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
PPHA_RS09100	COG3011	Protein conserved in bacteria
PPHA_RS09105	COG2944	sequence-specific DNA binding
PPHA_RS09160	COG3118	belongs to the thioredoxin family
PPHA_RS09175	COG0302	gtp cyclohydrolase
PPHA_RS09180	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
PPHA_RS09185	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
PPHA_RS09200	COG1007	ATP synthesis coupled electron transport
PPHA_RS09210	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
PPHA_RS09215	COG0713	ATP synthesis coupled electron transport
PPHA_RS09230	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
PPHA_RS09235	COG0649	NAD binding
PPHA_RS09240	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PPHA_RS09245	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PPHA_RS09250	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PPHA_RS09315	COG1538	Outer membrane efflux protein
PPHA_RS09320	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
PPHA_RS09325	COG0307	riboflavin synthase, alpha
PPHA_RS09330	COG1874	Beta-galactosidase
PPHA_RS09330	COG0366	Alpha amylase catalytic
PPHA_RS09335	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
PPHA_RS09355	COG1293	RNA-binding protein homologous to eukaryotic snRNP
PPHA_RS09365	COG1914	H( )-stimulated, divalent metal cation uptake system
PPHA_RS09440	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
PPHA_RS09460	COG0557	exoribonuclease II activity
PPHA_RS09470	COG0598	Magnesium transport protein CorA
PPHA_RS09475	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
PPHA_RS09505	COG4221	oxidoreductase activity
PPHA_RS09510	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
PPHA_RS09520	COG1077	Cell shape determining protein MreB Mrl
PPHA_RS09535	COG0667	Aldo Keto reductase
PPHA_RS09620	COG1262	PFAM Formylglycine-generating sulfatase enzyme
PPHA_RS09630	COG1262	PFAM Formylglycine-generating sulfatase enzyme
PPHA_RS09655	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
PPHA_RS09660	COG0347	Belongs to the P(II) protein family
PPHA_RS09690	COG0535	radical SAM domain protein
PPHA_RS09690	COG1433	Dinitrogenase iron-molybdenum cofactor
PPHA_RS09720	COG0501	Belongs to the peptidase M48B family
PPHA_RS09790	COG1262	PFAM Formylglycine-generating sulfatase enzyme
PPHA_RS09815	COG2189	Belongs to the N(4) N(6)-methyltransferase family
PPHA_RS09830	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
PPHA_RS09850	COG2375	cellular response to nickel ion
PPHA_RS09850	COG1132	(ABC) transporter
PPHA_RS09865	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
PPHA_RS09875	COG1120	ATPase activity
PPHA_RS09880	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PPHA_RS09910	COG4662	Binding-protein-dependent transport system inner membrane component
PPHA_RS09920	COG0626	cystathionine gamma-synthase activity
PPHA_RS09930	COG2022	thiamine diphosphate biosynthetic process
PPHA_RS09935	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
PPHA_RS09940	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
PPHA_RS09965	COG0567	Dehydrogenase, E1 component
PPHA_RS09970	COG0508	dehydrogenase complex catalyzes the overall conversion of
PPHA_RS09975	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PPHA_RS10015	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
PPHA_RS10045	COG3842	ATPase activity
PPHA_RS10080	COG3093	addiction module antidote protein HigA
PPHA_RS10125	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
PPHA_RS10165	COG0298	carbon dioxide binding
PPHA_RS10170	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
PPHA_RS10180	COG0375	protein maturation
PPHA_RS10185	COG0540	Belongs to the ATCase OTCase family
PPHA_RS10205	COG0589	response to stress
PPHA_RS10210	COG0477	Major facilitator Superfamily
PPHA_RS10220	COG0322	excinuclease ABC activity
PPHA_RS10230	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
PPHA_RS10235	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
PPHA_RS10240	COG0084	hydrolase, TatD family'
PPHA_RS10255	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
PPHA_RS10260	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
PPHA_RS10265	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
PPHA_RS10270	COG3278	Belongs to the heme-copper respiratory oxidase family
PPHA_RS10285	COG0348	domain, Protein
PPHA_RS10300	COG2217	Heavy metal translocating P-type atpase
PPHA_RS10335	COG0131	Imidazoleglycerol-phosphate dehydratase
PPHA_RS10340	COG1418	mRNA catabolic process
PPHA_RS10360	COG0072	phenylalanine-tRNA ligase activity
PPHA_RS10360	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PPHA_RS10390	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
PPHA_RS10395	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
PPHA_RS10400	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
PPHA_RS10410	COG0135	phosphoribosylanthranilate isomerase activity
PPHA_RS10420	COG0475	glutathione-regulated potassium exporter activity
PPHA_RS10420	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
PPHA_RS10425	COG0724	RNA recognition motif
PPHA_RS10440	COG0659	secondary active sulfate transmembrane transporter activity
PPHA_RS10465	COG0513	Belongs to the DEAD box helicase family
PPHA_RS10475	COG0626	cystathionine gamma-synthase activity
PPHA_RS10500	COG1598	PFAM Uncharacterised protein family UPF0150
PPHA_RS10525	COG4804	nuclease activity
PPHA_RS10540	COG1396	sequence-specific DNA binding
PPHA_RS10580	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
PPHA_RS10620	COG1678	Uncharacterized ACR, COG1678
PPHA_RS10625	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
PPHA_RS10630	COG0494	nUDIX hydrolase
PPHA_RS10640	COG0444	Belongs to the ABC transporter superfamily
PPHA_RS10645	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
PPHA_RS10650	COG0633	Ferredoxin
PPHA_RS10655	COG0633	Ferredoxin
PPHA_RS10660	COG0686	Belongs to the AlaDH PNT family
PPHA_RS10670	COG1595	DNA-templated transcription, initiation
PPHA_RS10680	COG0640	Transcriptional regulator
PPHA_RS10690	COG0443	Heat shock 70 kDa protein
PPHA_RS10705	COG2885	chlorophyll binding
PPHA_RS10710	COG2885	chlorophyll binding
PPHA_RS10715	COG0823	Involved in the tonB-independent uptake of proteins
PPHA_RS10725	COG0848	biopolymer transport protein
PPHA_RS10730	COG0811	peptide transport
PPHA_RS10735	COG0170	dolichyl monophosphate biosynthetic process
PPHA_RS10745	COG0129	dihydroxy-acid dehydratase activity
PPHA_RS10750	COG0028	Belongs to the TPP enzyme family
PPHA_RS10760	COG0440	acetolactate synthase activity
PPHA_RS10765	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
PPHA_RS10770	COG0473	3-isopropylmalate dehydrogenase activity
PPHA_RS10780	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
PPHA_RS10785	COG0066	3-isopropylmalate dehydratase activity
PPHA_RS10790	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
PPHA_RS10815	COG3040	lipid binding
PPHA_RS10820	COG1262	PFAM Formylglycine-generating sulfatase enzyme
PPHA_RS10820	COG0515	serine threonine protein kinase
PPHA_RS10825	COG1262	PFAM Formylglycine-generating sulfatase enzyme
PPHA_RS10825	COG0515	serine threonine protein kinase
PPHA_RS10880	COG1230	cation diffusion facilitator family transporter
PPHA_RS10885	COG0788	formyltetrahydrofolate deformylase activity
PPHA_RS10890	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
PPHA_RS10900	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
PPHA_RS10905	COG0463	Glycosyl transferase, family 2
PPHA_RS10915	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
PPHA_RS10920	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
PPHA_RS10920	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
PPHA_RS10925	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
PPHA_RS10930	COG1692	metallophosphoesterase
PPHA_RS10955	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
PPHA_RS10960	COG0003	Pfam Anion-transporting ATPase
PPHA_RS10965	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
PPHA_RS10995	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
PPHA_RS11000	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
PPHA_RS11005	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
PPHA_RS11010	COG1193	negative regulation of DNA recombination
PPHA_RS11110	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
PPHA_RS11115	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
PPHA_RS11120	COG1968	undecaprenyl-diphosphatase activity
PPHA_RS11125	COG0587	DNA-directed DNA polymerase activity
PPHA_RS11130	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
PPHA_RS11135	COG1127	ABC transporter
PPHA_RS11145	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
PPHA_RS11150	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
PPHA_RS11155	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
PPHA_RS11165	COG0138	bifunctional purine biosynthesis protein purh
PPHA_RS11230	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
PPHA_RS11255	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
PPHA_RS11260	COG0602	queuosine metabolic process
PPHA_RS11265	COG0463	Glycosyl transferase, family 2
PPHA_RS11270	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
PPHA_RS11290	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
PPHA_RS11300	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
PPHA_RS11310	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
PPHA_RS11310	COG0662	Cupin 2, conserved barrel domain protein
PPHA_RS11315	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
PPHA_RS11400	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
PPHA_RS11405	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
PPHA_RS11405	COG1648	precorrin-2 dehydrogenase activity
PPHA_RS11410	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
PPHA_RS11410	COG1648	precorrin-2 dehydrogenase activity
PPHA_RS11420	COG0437	4 iron, 4 sulfur cluster binding
PPHA_RS11445	COG2168	tRNA wobble position uridine thiolation
PPHA_RS11450	COG2923	Belongs to the DsrF TusC family
PPHA_RS11455	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
PPHA_RS11470	COG2221	Nitrite and sulphite reductase 4Fe-4S
PPHA_RS11475	COG2221	Nitrite and sulphite reductase 4Fe-4S
PPHA_RS11480	COG2920	part of a sulfur-relay system
PPHA_RS11485	COG1797	cobyrinic acid a,c-diamide synthase activity
PPHA_RS11490	COG0425	Belongs to the sulfur carrier protein TusA family
PPHA_RS11500	COG2210	Belongs to the sulfur carrier protein TusA family
PPHA_RS11545	COG1830	Aldolase
PPHA_RS11550	COG1028	Short-chain dehydrogenase reductase Sdr
PPHA_RS11550	COG3347	Dehydrogenase
PPHA_RS11565	COG1262	PFAM Formylglycine-generating sulfatase enzyme
PPHA_RS11565	COG0515	serine threonine protein kinase
PPHA_RS11585	COG1262	PFAM Formylglycine-generating sulfatase enzyme
PPHA_RS11585	COG0515	serine threonine protein kinase
PPHA_RS11615	COG0515	serine threonine protein kinase
PPHA_RS11615	COG1262	PFAM Formylglycine-generating sulfatase enzyme
PPHA_RS11620	COG2137	regulation of response to DNA damage stimulus
PPHA_RS11625	COG0528	UMP kinase activity
PPHA_RS11630	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
PPHA_RS11635	COG0052	Belongs to the universal ribosomal protein uS2 family
PPHA_RS11640	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
PPHA_RS11645	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
PPHA_RS11650	COG1160	GTP binding
PPHA_RS11655	COG0489	protein tyrosine kinase activity
PPHA_RS11660	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
PPHA_RS11665	COG1674	ftsk spoiiie
PPHA_RS11670	COG0404	The glycine cleavage system catalyzes the degradation of glycine
PPHA_RS11685	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
PPHA_RS11690	COG1704	LemA family
PPHA_RS11695	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
PPHA_RS11700	COG0556	nucleotide-excision repair
PPHA_RS11705	COG0612	Peptidase, M16
PPHA_RS11750	COG1262	PFAM Formylglycine-generating sulfatase enzyme
PPHA_RS11760	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
PPHA_RS11765	COG0525	valine-tRNA ligase activity
PPHA_RS11770	COG0740	serine-type endopeptidase activity
PPHA_RS11775	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
PPHA_RS11780	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
PPHA_RS11785	COG1752	Esterase of the alpha-beta hydrolase superfamily
PPHA_RS11790	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
PPHA_RS11795	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
PPHA_RS11810	COG1611	Belongs to the LOG family
PPHA_RS11815	COG0512	Glutamine amidotransferase of anthranilate synthase
PPHA_RS11820	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
PPHA_RS11830	COG4804	nuclease activity
PPHA_RS11835	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
PPHA_RS11845	COG1597	lipid kinase activity
PPHA_RS11855	COG1012	belongs to the aldehyde dehydrogenase family
PPHA_RS11860	COG1162	GTPase activity
PPHA_RS11865	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
PPHA_RS11870	COG0254	rRNA binding
PPHA_RS11875	COG0233	cytoplasmic translational termination
PPHA_RS11910	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
PPHA_RS11920	COG1570	exodeoxyribonuclease VII activity
PPHA_RS11925	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
PPHA_RS11930	COG1872	DUF167
PPHA_RS11935	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
PPHA_RS11940	COG0372	Belongs to the citrate synthase family
PPHA_RS11970	COG1169	isochorismate synthase
PPHA_RS11975	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
PPHA_RS11990	COG1943	Transposase
PPHA_RS11995	COG0515	serine threonine protein kinase
PPHA_RS11995	COG1262	PFAM Formylglycine-generating sulfatase enzyme
PPHA_RS12015	COG1846	Transcriptional regulator
PPHA_RS12020	COG0596	Alpha beta hydrolase
PPHA_RS12045	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
PPHA_RS12050	COG1475	DNA binding
PPHA_RS12055	COG1192	Involved in chromosome partitioning
PPHA_RS12060	COG2239	Acts as a magnesium transporter
PPHA_RS12080	COG3093	addiction module antidote protein HigA
PPHA_RS12100	COG1567	CRISPR-associated RAMP protein, Csm4 family
PPHA_RS12105	COG1337	RAMP superfamily
PPHA_RS12115	COG1353	crispr-associated protein
PPHA_RS12130	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
PPHA_RS12140	COG3177	Filamentation induced by cAMP protein fic
PPHA_RS12145	COG0482	sulfurtransferase activity
PPHA_RS12150	COG0400	carboxylic ester hydrolase activity
PPHA_RS12190	COG2989	Protein conserved in bacteria
PPHA_RS12215	COG0791	NLP P60 protein
PPHA_RS12230	COG1696	Membrane protein involved in D-alanine export
PPHA_RS12245	COG0363	glucosamine-6-phosphate deaminase activity
PPHA_RS12250	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
PPHA_RS12255	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
PPHA_RS12260	COG0438	transferase activity, transferring glycosyl groups
PPHA_RS12275	COG1752	Esterase of the alpha-beta hydrolase superfamily
PPHA_RS12280	COG1012	belongs to the aldehyde dehydrogenase family
PPHA_RS12285	COG0861	Integral membrane protein TerC family
PPHA_RS12295	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PPHA_RS12310	COG0826	peptidase U32
PPHA_RS12320	COG0543	2 iron, 2 sulfur cluster binding
PPHA_RS12325	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
PPHA_RS12330	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
PPHA_RS12340	COG3077	Addiction module antitoxin, RelB DinJ family
PPHA_RS12345	COG3041	Addiction module toxin RelE StbE family
PPHA_RS12425	COG2002	toxin-antitoxin pair type II binding
PPHA_RS12465	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
PPHA_RS12475	COG1278	Cold shock
PPHA_RS12480	COG1047	Peptidyl-prolyl cis-trans
PPHA_RS12490	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PPHA_RS12515	COG3335	DDE superfamily endonuclease
PPHA_RS12530	COG1078	dGTPase activity
PPHA_RS12540	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
PPHA_RS12545	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
PPHA_RS12565	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
PPHA_RS12590	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
PPHA_RS12595	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
PPHA_RS12600	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
PPHA_RS12610	COG0612	Peptidase, M16
PPHA_RS12615	COG0544	peptidyl-prolyl cis-trans isomerase activity
PPHA_RS12620	COG0736	holo-[acyl-carrier-protein] synthase activity
PPHA_RS12625	COG0157	Belongs to the NadC ModD family
PPHA_RS12640	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
PPHA_RS12665	COG0003	Pfam Anion-transporting ATPase
PPHA_RS12675	COG0629	single-stranded DNA binding
PPHA_RS12690	COG0156	8-amino-7-oxononanoate synthase activity
PPHA_RS12695	COG4771	TonB-dependent receptor
PPHA_RS12700	COG1429	ligase activity, forming nitrogen-metal bonds
PPHA_RS12715	COG1429	ligase activity, forming nitrogen-metal bonds
PPHA_RS12730	COG4115	mRNA cleavage
PPHA_RS12740	COG0438	transferase activity, transferring glycosyl groups
PPHA_RS12745	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
PPHA_RS12745	COG2755	lipolytic protein G-D-S-L family
PPHA_RS12750	COG0438	transferase activity, transferring glycosyl groups
PPHA_RS12775	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
PPHA_RS12795	COG1216	Glycosyl transferase, family 2
PPHA_RS12795	COG0463	Glycosyl transferase, family 2
PPHA_RS12800	COG1560	Kdo2-lipid A biosynthetic process
PPHA_RS12805	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
PPHA_RS12805	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
PPHA_RS12815	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
PPHA_RS12820	COG1573	uracil-dna glycosylase
PPHA_RS12825	COG0305	Participates in initiation and elongation during chromosome replication
PPHA_RS12830	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
PPHA_RS12840	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
PPHA_RS12850	COG0552	protein localization to endoplasmic reticulum
PPHA_RS12855	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
PPHA_RS12875	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
PPHA_RS12885	COG0542	response to heat
PPHA_RS12900	COG0735	belongs to the Fur family
PPHA_RS12905	COG0602	queuosine metabolic process
PPHA_RS12910	COG1328	CTP reductase activity
PPHA_RS12920	COG0508	dehydrogenase complex catalyzes the overall conversion of
PPHA_RS12930	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
PPHA_RS12950	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
PPHA_RS12955	COG0390	transport system, permease component
PPHA_RS12995	COG1233	COG1233 Phytoene dehydrogenase and related
PPHA_RS13005	COG0586	Pfam SNARE associated Golgi protein
PPHA_RS13015	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
PPHA_RS13020	COG0518	GMP synthase (glutamine-hydrolyzing) activity
PPHA_RS13020	COG0519	Catalyzes the synthesis of GMP from XMP
PPHA_RS13120	COG0560	Phosphoserine phosphatase
PPHA_RS13120	COG3830	Belongs to the UPF0237 family
PPHA_RS13135	COG0446	pyridine nucleotide-disulphide oxidoreductase
PPHA_RS13140	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
PPHA_RS13150	COG0674	pyruvate-flavodoxin oxidoreductase activity
PPHA_RS13150	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
PPHA_RS13155	COG1013	pyruvate-flavodoxin oxidoreductase activity
PPHA_RS13160	COG0825	malonyl-CoA metabolic process
PPHA_RS13170	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
PPHA_RS13175	COG0511	ligase activity, forming carbon-carbon bonds
PPHA_RS13180	COG0439	Biotin carboxylase
PPHA_RS13185	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
PPHA_RS13190	COG0085	RNA polymerase activity
PPHA_RS13195	COG0222	ribosome binding
PPHA_RS13200	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
PPHA_RS13205	COG0081	regulation of translation
PPHA_RS13210	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
PPHA_RS13215	COG0250	Participates in transcription elongation, termination and antitermination
PPHA_RS13220	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
PPHA_RS13245	COG0300	oxidoreductase activity
PPHA_RS13250	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
PPHA_RS13260	COG0148	phosphopyruvate hydratase activity
PPHA_RS13265	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
PPHA_RS13270	COG1216	Glycosyl transferase, family 2
PPHA_RS13285	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
PPHA_RS13305	COG1773	rubredoxin
PPHA_RS13310	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
PPHA_RS13320	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
PPHA_RS13325	COG1058	Belongs to the CinA family
PPHA_RS13325	COG1546	Belongs to the CinA family
PPHA_RS13335	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
PPHA_RS13340	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
PPHA_RS13345	COG0083	homoserine kinase activity
PPHA_RS13360	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
PPHA_RS13365	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
PPHA_RS13385	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
PPHA_RS13390	COG2048	Heterodisulfide reductase, subunit B
PPHA_RS13400	COG1053	succinate dehydrogenase
PPHA_RS13405	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
PPHA_RS13405	COG0517	IMP dehydrogenase activity
PPHA_RS13410	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PPHA_RS13465	COG1032	radical SAM domain protein
PPHA_RS13495	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
PPHA_RS13500	COG1028	Short-chain dehydrogenase reductase Sdr
PPHA_RS13525	COG1830	Aldolase
PPHA_RS13530	COG3347	Dehydrogenase
PPHA_RS13530	COG1028	Short-chain dehydrogenase reductase Sdr
PPHA_RS13555	COG2813	Specifically methylates the guanine in position
PPHA_RS13580	COG0003	Pfam Anion-transporting ATPase
PPHA_RS13585	COG1032	radical SAM domain protein
PPHA_RS13590	COG2813	Specifically methylates the guanine in position
PPHA_RS13605	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
PPHA_RS13610	COG3876	Protein conserved in bacteria
PPHA_RS13625	COG0745	RESPONSE REGULATOR receiver
PPHA_RS13630	COG0702	epimerase
PPHA_RS13650	COG0861	Integral membrane protein TerC family
PPHA_RS13655	COG3158	transport of potassium into the cell
PPHA_RS13660	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
PPHA_RS13665	COG4232	protein-disulfide reductase activity
PPHA_RS13680	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
PPHA_RS13685	COG1487	ribonuclease activity
PPHA_RS13695	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
PPHA_RS13700	COG3956	TIGRFAM MazG family protein
PPHA_RS13710	COG0366	Alpha amylase catalytic
PPHA_RS13715	COG0366	Alpha amylase catalytic
PPHA_RS13720	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
PPHA_RS13740	COG1970	mechanosensitive ion channel activity
PPHA_RS13745	COG0156	8-amino-7-oxononanoate synthase activity
PPHA_RS13785	COG1381	Involved in DNA repair and RecF pathway recombination
PPHA_RS13790	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
PPHA_RS13795	COG1993	acr, cog1993
PPHA_RS13800	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
PPHA_RS13815	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
PPHA_RS13820	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
PPHA_RS13830	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
PPHA_RS13845	COG2877	3-deoxy-8-phosphooctulonate synthase activity
PPHA_RS13850	COG0542	response to heat
PPHA_RS13855	COG1472	Belongs to the glycosyl hydrolase 3 family
PPHA_RS13865	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
PPHA_RS13870	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
PPHA_RS13875	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
PPHA_RS13880	COG0527	aspartate kinase activity
PPHA_RS13885	COG0791	NLP P60 protein
PPHA_RS13890	COG2264	protein methyltransferase activity
PPHA_RS13895	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
PPHA_RS13895	COG0248	Ppx GppA phosphatase
PPHA_RS13950	COG0318	PFAM AMP-dependent synthetase and ligase
PPHA_RS13960	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
PPHA_RS13965	COG4106	trans-aconitate 2-methyltransferase activity
PPHA_RS13975	COG0156	8-amino-7-oxononanoate synthase activity
PPHA_RS13980	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
PPHA_RS13985	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
PPHA_RS13985	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
PPHA_RS13990	COG0860	N-Acetylmuramoyl-L-alanine amidase
PPHA_RS13995	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
PPHA_RS14000	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
PPHA_RS14000	COG1918	ferrous iron import across plasma membrane
PPHA_RS14005	COG1918	ferrous iron import across plasma membrane
PPHA_RS14010	COG0537	adenosine 5'-monophosphoramidase activity
PPHA_RS14015	COG1253	flavin adenine dinucleotide binding
PPHA_RS14045	COG1053	succinate dehydrogenase
PPHA_RS14080	COG0798	PFAM Bile acid sodium symporter
PPHA_RS14085	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
PPHA_RS14090	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
PPHA_RS14095	COG0704	Plays a role in the regulation of phosphate uptake
PPHA_RS14145	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
PPHA_RS14150	COG1899	peptidyl-lysine modification to peptidyl-hypusine
PPHA_RS14155	COG0180	Tryptophanyl-tRNA synthetase
PPHA_RS14160	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
PPHA_RS14165	COG0018	arginyl-trna synthetase
PPHA_RS14170	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
PPHA_RS14185	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
PPHA_RS14190	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
PPHA_RS14195	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
PPHA_RS14200	COG0356	it plays a direct role in the translocation of protons across the membrane
PPHA_RS14215	COG1496	oxidoreductase activity
PPHA_RS14220	COG0427	acetyl-CoA hydrolase
PPHA_RS14225	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
PPHA_RS14240	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
PPHA_RS14245	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
PPHA_RS14250	COG0772	Belongs to the SEDS family
PPHA_RS14255	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
PPHA_RS14260	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
PPHA_RS14265	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
PPHA_RS14270	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
PPHA_RS14275	COG0768	penicillin binding
PPHA_RS14285	COG0275	rRNA processing
PPHA_RS14290	COG2001	Belongs to the MraZ family
PPHA_RS14305	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
PPHA_RS14310	COG0126	phosphoglycerate kinase activity
PPHA_RS14315	COG0457	Tetratricopeptide repeat
PPHA_RS14315	COG0705	Rhomboid family
PPHA_RS14325	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
PPHA_RS14380	COG0671	phosphoesterase, PA-phosphatase related
PPHA_RS14385	COG0706	membrane insertase activity
PPHA_RS14390	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
PPHA_RS14395	COG0594	ribonuclease P activity
PPHA_RS14425	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
PPHA_RS14515	COG1262	PFAM Formylglycine-generating sulfatase enzyme
PPHA_RS14525	COG0631	protein serine/threonine phosphatase activity
PPHA_RS14530	COG3152	Membrane
PPHA_RS14535	COG0515	serine threonine protein kinase
PPHA_RS14535	COG2815	serine threonine protein kinase
PPHA_RS14550	COG4191	Histidine kinase
PPHA_RS14550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PPHA_RS14570	COG1803	Methylglyoxal synthase
PPHA_RS14580	COG1773	rubredoxin
PPHA_RS14595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PPHA_RS14595	COG4191	Histidine kinase
PPHA_RS14640	COG0737	Belongs to the 5'-nucleotidase family
PPHA_RS14645	COG0842	Transport permease protein
PPHA_RS14655	COG2205	protein histidine kinase activity
PPHA_RS14660	COG5002	protein histidine kinase activity
PPHA_RS14665	COG1262	PFAM Formylglycine-generating sulfatase enzyme
PPHA_RS14675	COG0745	RESPONSE REGULATOR receiver
PPHA_RS14760	COG1216	Glycosyl transferase, family 2
PPHA_RS14760	COG0438	transferase activity, transferring glycosyl groups