locus-tag	class	description
CD196_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CD196_RS00010	COG0592	DNA-directed DNA polymerase activity
CD196_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CD196_RS00025	COG0187	DNA topoisomerase II activity
CD196_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CD196_RS00045	COG1366	Belongs to the anti-sigma-factor antagonist family
CD196_RS00055	COG1191	sigma factor activity
CD196_RS00080	COG1827	regulation of RNA biosynthetic process
CD196_RS00085	COG0668	transmembrane transport
CD196_RS00090	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CD196_RS00095	COG0590	tRNA wobble adenosine to inosine editing
CD196_RS00105	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CD196_RS00110	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CD196_RS00115	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CD196_RS00125	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CD196_RS00365	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CD196_RS00370	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CD196_RS00375	COG4463	regulation of RNA biosynthetic process
CD196_RS00380	COG3880	PFAM UvrB UvrC protein
CD196_RS00385	COG3869	Catalyzes the specific phosphorylation of arginine residues in
CD196_RS00390	COG0542	response to heat
CD196_RS00395	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CD196_RS00400	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
CD196_RS00405	COG4956	integral membrane protein (PIN domain superfamily)
CD196_RS00425	COG3507	Belongs to the glycosyl hydrolase 43 family
CD196_RS00435	COG2390	Transcriptional regulator
CD196_RS00440	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CD196_RS00445	COG0022	dehydrogenase e1 component
CD196_RS00450	COG0508	dehydrogenase complex catalyzes the overall conversion of
CD196_RS00455	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CD196_RS00460	COG3933	PFAM sigma-54 factor interaction domain-containing protein
CD196_RS00460	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CD196_RS00470	COG3414	Phosphotransferase system galactitol-specific IIB component
CD196_RS00475	COG3775	system Galactitol-specific IIC component
CD196_RS00490	COG0095	Lipoate-protein ligase
CD196_RS00495	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CD196_RS00500	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CD196_RS00505	COG0442	prolyl-tRNA aminoacylation
CD196_RS00510	COG0442	prolyl-tRNA aminoacylation
CD196_RS00515	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CD196_RS00525	COG0215	cysteine-tRNA ligase activity
CD196_RS00540	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CD196_RS00550	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CD196_RS00560	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CD196_RS00565	COG3688	RNA-binding protein containing a PIN domain
CD196_RS00575	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CD196_RS00580	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CD196_RS00590	COG0250	Participates in transcription elongation, termination and antitermination
CD196_RS00595	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CD196_RS00600	COG0081	regulation of translation
CD196_RS00605	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CD196_RS00610	COG0222	ribosome binding
CD196_RS00620	COG0085	RNA polymerase activity
CD196_RS00625	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CD196_RS00630	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CD196_RS00635	COG0049	tRNA binding
CD196_RS00640	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CD196_RS00645	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CD196_RS00650	COG0051	transcription antitermination factor activity, RNA binding
CD196_RS00655	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CD196_RS00660	COG0088	Forms part of the polypeptide exit tunnel
CD196_RS00665	COG0089	rRNA binding
CD196_RS00670	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CD196_RS00675	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CD196_RS00680	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CD196_RS00685	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CD196_RS00690	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CD196_RS00695	COG0255	Belongs to the universal ribosomal protein uL29 family
CD196_RS00700	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CD196_RS00705	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CD196_RS00710	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CD196_RS00715	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CD196_RS00720	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CD196_RS00725	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CD196_RS00730	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CD196_RS00735	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CD196_RS00740	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CD196_RS00745	COG1841	ribosomal large subunit assembly
CD196_RS00750	COG0200	Binds to the 23S rRNA
CD196_RS00760	COG0563	adenylate kinase activity
CD196_RS00765	COG0024	Methionine aminopeptidase
CD196_RS00775	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CD196_RS00780	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CD196_RS00785	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CD196_RS00790	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CD196_RS00795	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CD196_RS00800	COG0202	RNA polymerase activity
CD196_RS00805	COG0203	ribosomal protein L17
CD196_RS00810	COG1122	ATPase activity
CD196_RS00815	COG1122	ATPase activity
CD196_RS00820	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CD196_RS00825	COG0101	tRNA pseudouridine synthase activity
CD196_RS00835	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CD196_RS00840	COG0860	N-Acetylmuramoyl-L-alanine amidase
CD196_RS01050	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CD196_RS01065	COG0280	phosphate acetyltransferase
CD196_RS01100	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CD196_RS01105	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CD196_RS01110	COG2897	thiosulfate sulfurtransferase activity
CD196_RS01120	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CD196_RS01125	COG2385	sporulation resulting in formation of a cellular spore
CD196_RS01135	COG1609	Transcriptional regulator
CD196_RS01140	COG1077	Cell shape determining protein MreB Mrl
CD196_RS01145	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CD196_RS01155	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CD196_RS01160	COG3949	Membrane
CD196_RS01165	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CD196_RS01170	COG1040	competence protein
CD196_RS01175	COG3711	transcriptional antiterminator
CD196_RS01175	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CD196_RS01180	COG1447	Phosphotransferase system cellobiose-specific component IIA
CD196_RS01185	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CD196_RS01190	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CD196_RS01200	COG1446	asparaginase
CD196_RS01205	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CD196_RS01215	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CD196_RS01220	COG0653	protein targeting
CD196_RS01225	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CD196_RS01230	COG2183	response to ionizing radiation
CD196_RS01235	COG1228	amidohydrolase
CD196_RS01250	COG0802	atpase or kinase
CD196_RS01255	COG1214	PFAM Peptidase M22, glycoprotease
CD196_RS01260	COG0456	acetyltransferase
CD196_RS01265	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CD196_RS01300	COG3279	Response regulator of the LytR AlgR family
CD196_RS01340	COG1473	amidohydrolase
CD196_RS01355	COG0534	Mate efflux family protein
CD196_RS01360	COG0488	(ABC) transporter
CD196_RS01365	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CD196_RS01375	COG2221	Nitrite and sulphite reductase 4Fe-4S
CD196_RS01385	COG1151	hydroxylamine reductase activity
CD196_RS01400	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CD196_RS01435	COG0540	Belongs to the ATCase OTCase family
CD196_RS01440	COG0543	2 iron, 2 sulfur cluster binding
CD196_RS01445	COG0167	dihydroorotate dehydrogenase activity
CD196_RS01450	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CD196_RS01460	COG0583	DNA-binding transcription factor activity
CD196_RS01475	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CD196_RS01480	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CD196_RS01485	COG0459	protein refolding
CD196_RS01490	COG1691	(AIR) carboxylase
CD196_RS01495	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
CD196_RS01500	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
CD196_RS01505	COG0519	Catalyzes the synthesis of GMP from XMP
CD196_RS01505	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CD196_RS01535	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CD196_RS01540	COG2200	EAL domain
CD196_RS01540	COG2771	luxR family
CD196_RS01555	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CD196_RS01560	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CD196_RS01570	COG1011	Hydrolase
CD196_RS01585	COG0778	Nitroreductase
CD196_RS01590	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CD196_RS01595	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CD196_RS01600	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CD196_RS01605	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CD196_RS01610	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CD196_RS01615	COG0138	bifunctional purine biosynthesis protein purh
CD196_RS01620	COG0151	Belongs to the GarS family
CD196_RS01625	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CD196_RS01635	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CD196_RS01645	COG1088	dTDP-glucose 4,6-dehydratase activity
CD196_RS01650	COG0741	lytic transglycosylase activity
CD196_RS01685	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
CD196_RS01690	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CD196_RS01705	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CD196_RS01715	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CD196_RS01725	COG0463	Glycosyl transferase, family 2
CD196_RS01760	COG4786	Flagellar basal body rod
CD196_RS01770	COG1677	Flagellar hook-basal body complex protein FliE
CD196_RS01775	COG1766	The M ring may be actively involved in energy transduction
CD196_RS01780	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CD196_RS01790	COG1157	protein secretion by the type III secretion system
CD196_RS01805	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CD196_RS01810	COG4786	Flagellar basal body rod
CD196_RS01820	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CD196_RS01840	COG1338	Plays a role in the flagellum-specific transport system
CD196_RS01850	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CD196_RS01855	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CD196_RS01860	COG1419	protein localization to endoplasmic reticulum
CD196_RS01870	COG1191	sigma factor activity
CD196_RS01885	COG4786	Flagellar basal body rod
CD196_RS01900	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CD196_RS01900	COG1776	CheC inhibitor of MCP methylation
CD196_RS01915	COG1454	alcohol dehydrogenase
CD196_RS01920	COG1533	DNA photolyase activity
CD196_RS01935	COG1733	regulation of RNA biosynthetic process
CD196_RS01950	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CD196_RS01955	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CD196_RS01955	COG3933	PFAM sigma-54 factor interaction domain-containing protein
CD196_RS01960	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CD196_RS01960	COG3933	PFAM sigma-54 factor interaction domain-containing protein
CD196_RS01985	COG3716	PTS system mannose fructose sorbose family IID component
CD196_RS01995	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CD196_RS02000	COG3620	sequence-specific DNA binding
CD196_RS02010	COG1131	(ABC) transporter
CD196_RS02030	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CD196_RS02035	COG1609	Transcriptional regulator
CD196_RS02040	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CD196_RS02045	COG1879	ABC-type sugar transport system periplasmic component
CD196_RS02050	COG1129	ABC transporter
CD196_RS02055	COG1172	Belongs to the binding-protein-dependent transport system permease family
CD196_RS02060	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CD196_RS02070	COG1473	amidohydrolase
CD196_RS02125	COG2217	Heavy metal translocating P-type atpase
CD196_RS02145	COG0586	Pfam SNARE associated Golgi protein
CD196_RS02175	COG2205	protein histidine kinase activity
CD196_RS02180	COG0745	RESPONSE REGULATOR receiver
CD196_RS02205	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
CD196_RS02215	COG1122	ATPase activity
CD196_RS02220	COG0210	DNA helicase
CD196_RS02225	COG1362	aminopeptidase activity
CD196_RS02235	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CD196_RS02260	COG1012	belongs to the aldehyde dehydrogenase family
CD196_RS02260	COG1454	alcohol dehydrogenase
CD196_RS02270	COG1136	(ABC) transporter
CD196_RS02280	COG3290	protein histidine kinase activity
CD196_RS02310	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CD196_RS02315	COG2357	RelA SpoT domain protein
CD196_RS02335	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
CD196_RS02360	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CD196_RS02360	COG1263	PTS System
CD196_RS02360	COG2190	(PTS) system
CD196_RS02365	COG2723	6-phospho-beta-galactosidase activity
CD196_RS02370	COG3711	transcriptional antiterminator
CD196_RS02380	COG0367	asparagine synthase
CD196_RS02395	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CD196_RS02420	COG1960	acyl-CoA dehydrogenase activity
CD196_RS02425	COG2086	electron transfer activity
CD196_RS02430	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CD196_RS02435	COG3829	transcription factor binding
CD196_RS02440	COG0191	fructose-bisphosphate aldolase activity
CD196_RS02450	COG1187	pseudouridine synthase activity
CD196_RS02460	COG1187	pseudouridine synthase activity
CD196_RS02495	COG2801	Transposase and inactivated derivatives
CD196_RS02505	COG3829	transcription factor binding
CD196_RS02510	COG3804	dihydrodipicolinate reductase
CD196_RS02520	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CD196_RS02530	COG5012	cobalamin binding
CD196_RS02540	COG3457	Alanine racemase
CD196_RS02545	COG1757	Na H antiporter
CD196_RS02565	COG3973	AAA domain
CD196_RS02570	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CD196_RS02585	COG1136	(ABC) transporter
CD196_RS02595	COG5002	protein histidine kinase activity
CD196_RS02600	COG0745	RESPONSE REGULATOR receiver
CD196_RS02635	COG1737	Transcriptional regulator
CD196_RS02645	COG0561	phosphatase activity
CD196_RS02650	COG0366	Alpha amylase catalytic
CD196_RS02670	COG0655	NAD(P)H dehydrogenase (quinone) activity
CD196_RS02700	COG1131	(ABC) transporter
CD196_RS02720	COG5002	protein histidine kinase activity
CD196_RS02730	COG1136	(ABC) transporter
CD196_RS02730	COG0577	efflux transmembrane transporter activity
CD196_RS02735	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CD196_RS02745	COG0745	RESPONSE REGULATOR receiver
CD196_RS02750	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CD196_RS02765	COG1063	alcohol dehydrogenase
CD196_RS02775	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CD196_RS02785	COG3716	PTS system mannose fructose sorbose family IID component
CD196_RS02795	COG5002	protein histidine kinase activity
CD196_RS02805	COG1686	Belongs to the peptidase S11 family
CD196_RS02810	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CD196_RS02810	COG3933	PFAM sigma-54 factor interaction domain-containing protein
CD196_RS02830	COG2205	protein histidine kinase activity
CD196_RS02855	COG2195	Cleaves the N-terminal amino acid of tripeptides
CD196_RS02860	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CD196_RS02885	COG2378	regulation of single-species biofilm formation
CD196_RS02895	COG2201	protein-glutamate methylesterase activity
CD196_RS02900	COG1776	CheC inhibitor of MCP methylation
CD196_RS02905	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
CD196_RS02910	COG0835	chemotaxis
CD196_RS02920	COG0840	transmembrane signaling receptor activity
CD196_RS02925	COG2198	Histidine kinase
CD196_RS02925	COG0643	Histidine kinase
CD196_RS02930	COG0835	chemotaxis
CD196_RS02940	COG2201	protein-glutamate methylesterase activity
CD196_RS02990	COG2339	peptidase activity
CD196_RS02995	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
CD196_RS02995	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CD196_RS03000	COG0681	Belongs to the peptidase S26 family
CD196_RS03015	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CD196_RS03020	COG2066	Belongs to the glutaminase family
CD196_RS03030	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CD196_RS03050	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CD196_RS03055	COG1067	ATP-dependent peptidase activity
CD196_RS03060	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CD196_RS03065	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CD196_RS03075	COG1744	ABC transporter substrate-binding protein PnrA-like
CD196_RS03100	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CD196_RS03165	COG1309	transcriptional regulator
CD196_RS03170	COG0574	Belongs to the PEP-utilizing enzyme family
CD196_RS03170	COG3848	Pyruvate phosphate dikinase
CD196_RS03180	COG5001	Diguanylate cyclase
CD196_RS03180	COG3300	MHYT domain
CD196_RS03240	COG3969	phosphoadenosine phosphosulfate
CD196_RS03245	COG1475	DNA binding
CD196_RS03260	COG3546	catalase activity
CD196_RS03265	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CD196_RS03290	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
CD196_RS03325	COG3279	Response regulator of the LytR AlgR family
CD196_RS03330	COG0577	efflux transmembrane transporter activity
CD196_RS03335	COG1136	(ABC) transporter
CD196_RS03350	COG4978	Transcriptional regulator
CD196_RS03350	COG0789	Transcriptional regulator
CD196_RS03395	COG0305	Participates in initiation and elongation during chromosome replication
CD196_RS03415	COG1132	(ABC) transporter
CD196_RS03420	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CD196_RS03425	COG0534	Mate efflux family protein
CD196_RS03435	COG4335	DNA alkylation repair
CD196_RS03490	COG0745	RESPONSE REGULATOR receiver
CD196_RS03495	COG2205	protein histidine kinase activity
CD196_RS03500	COG1131	(ABC) transporter
CD196_RS03510	COG3177	Filamentation induced by cAMP protein fic
CD196_RS03515	COG1802	Transcriptional regulator
CD196_RS03520	COG0823	Involved in the tonB-independent uptake of proteins
CD196_RS03520	COG1506	peptidase
CD196_RS03520	COG4946	Tricorn protease homolog
CD196_RS03525	COG1506	peptidase
CD196_RS03525	COG4946	Tricorn protease homolog
CD196_RS03525	COG0823	Involved in the tonB-independent uptake of proteins
CD196_RS03545	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CD196_RS03565	COG0038	chloride channel
CD196_RS03645	COG2205	protein histidine kinase activity
CD196_RS03685	COG1595	DNA-templated transcription, initiation
CD196_RS03700	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
CD196_RS03720	COG2814	Major facilitator Superfamily
CD196_RS03735	COG1609	Transcriptional regulator
CD196_RS03745	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CD196_RS03750	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CD196_RS03755	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CD196_RS03785	COG0789	Transcriptional regulator
CD196_RS03805	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CD196_RS03810	COG0569	domain protein
CD196_RS03815	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CD196_RS03820	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CD196_RS03825	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CD196_RS03825	COG0072	phenylalanine-tRNA ligase activity
CD196_RS03840	COG0826	peptidase U32
CD196_RS03850	COG1051	belongs to the nudix hydrolase family
CD196_RS03860	COG3706	GGDEF domain
CD196_RS03865	COG2195	Cleaves the N-terminal amino acid of tripeptides
CD196_RS03870	COG1193	negative regulation of DNA recombination
CD196_RS03875	COG1683	Conserved Protein
CD196_RS03880	COG0018	arginyl-trna synthetase
CD196_RS03895	COG1032	radical SAM domain protein
CD196_RS03905	COG0280	phosphate acetyltransferase
CD196_RS03910	COG1151	hydroxylamine reductase activity
CD196_RS03920	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CD196_RS03925	COG3404	Formiminotransferase-cyclodeaminase
CD196_RS03930	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CD196_RS03940	COG0646	methionine synthase
CD196_RS03940	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CD196_RS03945	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CD196_RS03975	COG0509	glycine decarboxylation via glycine cleavage system
CD196_RS03995	COG0095	Lipoate-protein ligase
CD196_RS04015	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CD196_RS04030	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CD196_RS04030	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CD196_RS04040	COG3192	ethanolamine utilization protein
CD196_RS04045	COG1349	DNA-binding transcription factor activity
CD196_RS04055	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CD196_RS04060	COG1360	Flagellar Motor Protein
CD196_RS04080	COG0210	DNA helicase
CD196_RS04085	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CD196_RS04090	COG0765	amino acid transport
CD196_RS04095	COG1126	abc transporter atp-binding protein
CD196_RS04105	COG0301	tRNA thio-modification
CD196_RS04115	COG0778	Nitroreductase
CD196_RS04120	COG5001	Diguanylate cyclase
CD196_RS04120	COG3300	MHYT domain
CD196_RS04125	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CD196_RS04135	COG0530	calcium, potassium:sodium antiporter activity
CD196_RS04140	COG0513	Belongs to the DEAD box helicase family
CD196_RS04170	COG1028	Short-chain dehydrogenase reductase Sdr
CD196_RS04180	COG0243	molybdopterin cofactor binding
CD196_RS04185	COG1366	Belongs to the anti-sigma-factor antagonist family
CD196_RS04190	COG2172	sigma factor antagonist activity
CD196_RS04195	COG1191	sigma factor activity
CD196_RS04205	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CD196_RS04230	COG1473	amidohydrolase
CD196_RS04240	COG0295	cytidine deaminase activity
CD196_RS04245	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CD196_RS04255	COG0750	zinc metalloprotease
CD196_RS04260	COG0860	N-Acetylmuramoyl-L-alanine amidase
CD196_RS04265	COG0488	(ABC) transporter
CD196_RS04280	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CD196_RS04295	COG1739	Uncharacterized protein family UPF0029
CD196_RS04305	COG0730	response to heat
CD196_RS04310	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CD196_RS04315	COG0217	transcriptional regulatory protein
CD196_RS04325	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CD196_RS04340	COG1024	Enoyl-CoA hydratase
CD196_RS04345	COG2610	gluconate transmembrane transporter activity
CD196_RS04360	COG2086	electron transfer activity
CD196_RS04365	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CD196_RS04410	COG2186	Transcriptional regulator
CD196_RS04415	COG2814	Major facilitator Superfamily
CD196_RS04420	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CD196_RS04420	COG1263	PTS System
CD196_RS04420	COG2190	(PTS) system
CD196_RS04425	COG2723	6-phospho-beta-galactosidase activity
CD196_RS04435	COG0745	RESPONSE REGULATOR receiver
CD196_RS04440	COG2205	protein histidine kinase activity
CD196_RS04460	COG1592	Rubrerythrin
CD196_RS04470	COG2033	superoxide reductase activity
CD196_RS04475	COG0069	glutamate synthase activity
CD196_RS04495	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CD196_RS04505	COG0473	3-isopropylmalate dehydrogenase activity
CD196_RS04510	COG1846	Transcriptional regulator
CD196_RS04535	COG0179	Fumarylacetoacetate (FAA) hydrolase
CD196_RS04540	COG0138	bifunctional purine biosynthesis protein purh
CD196_RS04550	COG0438	transferase activity, transferring glycosyl groups
CD196_RS04550	COG0297	glycogen (starch) synthase activity
CD196_RS04580	COG1473	amidohydrolase
CD196_RS04585	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CD196_RS04600	COG0601	transmembrane transport
CD196_RS04605	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CD196_RS04615	COG0444	Belongs to the ABC transporter superfamily
CD196_RS04620	COG4608	Belongs to the ABC transporter superfamily
CD196_RS04625	COG3933	PFAM sigma-54 factor interaction domain-containing protein
CD196_RS04625	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CD196_RS04645	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CD196_RS04655	COG1486	melibiose metabolic process
CD196_RS04665	COG1073	alpha beta
CD196_RS04675	COG1910	domain protein
CD196_RS04680	COG0725	ABC transporter, periplasmic molybdate-binding protein
CD196_RS04685	COG4149	molybdate abc transporter
CD196_RS04690	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CD196_RS04695	COG0110	maltose O-acetyltransferase activity
CD196_RS04705	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CD196_RS04710	COG4120	Belongs to the binding-protein-dependent transport system permease family
CD196_RS04715	COG2984	ABC transporter substrate binding protein
CD196_RS04720	COG1122	ATPase activity
CD196_RS04725	COG4120	Belongs to the binding-protein-dependent transport system permease family
CD196_RS04730	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CD196_RS04730	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CD196_RS04750	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CD196_RS04755	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CD196_RS04760	COG0297	glycogen (starch) synthase activity
CD196_RS04765	COG0058	SHG alpha-glucan phosphorylase activity
CD196_RS04775	COG1802	Transcriptional regulator
CD196_RS04780	COG1982	Orn Lys Arg decarboxylase major
CD196_RS04785	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CD196_RS04790	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CD196_RS04795	COG0010	Belongs to the arginase family
CD196_RS04840	COG4868	Belongs to the UPF0371 family
CD196_RS04845	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CD196_RS04855	COG1174	glycine betaine transport
CD196_RS04860	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CD196_RS04890	COG0534	Mate efflux family protein
CD196_RS04895	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CD196_RS04895	COG0539	negative regulation of cytoplasmic translation
CD196_RS04900	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CD196_RS04910	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CD196_RS04915	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CD196_RS04920	COG0066	3-isopropylmalate dehydratase activity
CD196_RS04925	COG0473	3-isopropylmalate dehydrogenase activity
CD196_RS04940	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CD196_RS04950	COG3447	MASE1 domain protein
CD196_RS04950	COG5002	protein histidine kinase activity
CD196_RS04950	COG5001	Diguanylate cyclase
CD196_RS04975	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CD196_RS04980	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
CD196_RS04990	COG0281	malic enzyme
CD196_RS05000	COG0745	RESPONSE REGULATOR receiver
CD196_RS05005	COG5002	protein histidine kinase activity
CD196_RS05010	COG0577	efflux transmembrane transporter activity
CD196_RS05010	COG1136	(ABC) transporter
CD196_RS05030	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CD196_RS05035	COG0363	glucosamine-6-phosphate deaminase activity
CD196_RS05050	COG5002	protein histidine kinase activity
CD196_RS05055	COG5001	Diguanylate cyclase
CD196_RS05065	COG4978	Transcriptional regulator
CD196_RS05065	COG0789	Transcriptional regulator
CD196_RS05075	COG1132	(ABC) transporter
CD196_RS05095	COG2364	Membrane
CD196_RS05105	COG3842	ATPase activity
CD196_RS05110	COG1176	ABC-type spermidine putrescine transport system, permease component I
CD196_RS05115	COG1177	transmembrane transport
CD196_RS05120	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CD196_RS05130	COG5298	Protein conserved in bacteria
CD196_RS05135	COG1215	transferase activity, transferring glycosyl groups
CD196_RS05150	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CD196_RS05180	COG0860	N-Acetylmuramoyl-L-alanine amidase
CD196_RS05185	COG2247	cell wall binding repeat
CD196_RS05185	COG0860	N-Acetylmuramoyl-L-alanine amidase
CD196_RS05195	COG0210	DNA helicase
CD196_RS05205	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
CD196_RS05210	COG1074	ATP-dependent DNA helicase activity
CD196_RS05215	COG0420	3'-5' exonuclease activity
CD196_RS05220	COG0419	ATPase involved in DNA repair
CD196_RS05225	COG4536	flavin adenine dinucleotide binding
CD196_RS05235	COG2195	Cleaves the N-terminal amino acid of tripeptides
CD196_RS05245	COG0622	Phosphoesterase
CD196_RS05250	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CD196_RS05255	COG1131	(ABC) transporter
CD196_RS05270	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CD196_RS05275	COG1960	acyl-CoA dehydrogenase activity
CD196_RS05280	COG2086	electron transfer activity
CD196_RS05285	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CD196_RS05300	COG0183	Belongs to the thiolase family
CD196_RS05305	COG0564	pseudouridine synthase activity
CD196_RS05315	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CD196_RS05365	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CD196_RS05370	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CD196_RS05375	COG4224	UPF0291 protein
CD196_RS05380	COG1362	aminopeptidase activity
CD196_RS05385	COG2188	Transcriptional regulator
CD196_RS05405	COG3715	PTS system
CD196_RS05410	COG3716	PTS system mannose fructose sorbose family IID component
CD196_RS05415	COG0583	DNA-binding transcription factor activity
CD196_RS05435	COG3414	Phosphotransferase system galactitol-specific IIB component
CD196_RS05440	COG1132	(ABC) transporter
CD196_RS05450	COG1473	amidohydrolase
CD196_RS05465	COG3279	Response regulator of the LytR AlgR family
CD196_RS05480	COG1882	Formate acetyltransferase
CD196_RS05485	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CD196_RS05490	COG1396	sequence-specific DNA binding
CD196_RS05515	COG3708	Transcriptional regulator
CD196_RS05515	COG2207	Transcriptional regulator
CD196_RS05555	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CD196_RS05555	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CD196_RS05560	COG0237	dephospho-CoA kinase activity
CD196_RS05585	COG0346	lactoylglutathione lyase activity
CD196_RS05590	COG0791	NLP P60 protein
CD196_RS05600	COG4656	Part of a membrane complex involved in electron transport
CD196_RS05605	COG4658	electron transport chain
CD196_RS05610	COG4659	FMN binding
CD196_RS05615	COG4660	Part of a membrane complex involved in electron transport
CD196_RS05620	COG4657	Part of a membrane complex involved in electron transport
CD196_RS05625	COG2878	Part of a membrane complex involved in electron transport
CD196_RS05625	COG1245	4Fe-4S binding domain
CD196_RS05630	COG0424	maF-like protein
CD196_RS05635	COG2003	Belongs to the UPF0758 family
CD196_RS05640	COG1077	Cell shape determining protein MreB Mrl
CD196_RS05660	COG0850	regulation of cytokinetic process
CD196_RS05665	COG2894	cell division
CD196_RS05670	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CD196_RS05675	COG0772	Belongs to the SEDS family
CD196_RS05680	COG1803	Methylglyoxal synthase
CD196_RS05685	COG1695	Transcriptional regulator
CD196_RS05700	COG0426	domain, Protein
CD196_RS05715	COG1530	ribonuclease E activity
CD196_RS05720	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CD196_RS05730	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CD196_RS05735	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CD196_RS05745	COG0460	homoserine dehydrogenase
CD196_RS05755	COG3314	Sporulation integral membrane protein YlbJ
CD196_RS05760	COG2186	Transcriptional regulator
CD196_RS05765	COG3875	lactate racemase activity
CD196_RS05770	COG2086	electron transfer activity
CD196_RS05775	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CD196_RS05780	COG0277	FAD linked oxidase domain protein
CD196_RS05785	COG1323	Belongs to the UPF0348 family
CD196_RS05790	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CD196_RS05800	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CD196_RS05810	COG0416	fatty acid biosynthetic process
CD196_RS05815	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CD196_RS05830	COG1028	Short-chain dehydrogenase reductase Sdr
CD196_RS05835	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CD196_RS05840	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CD196_RS05845	COG3706	GGDEF domain
CD196_RS05860	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CD196_RS05875	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
CD196_RS05880	COG3854	ATPases associated with a variety of cellular activities
CD196_RS05920	COG1302	Protein conserved in bacteria
CD196_RS05925	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CD196_RS05930	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CD196_RS05935	COG1570	exodeoxyribonuclease VII activity
CD196_RS05950	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
CD196_RS05955	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CD196_RS05960	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CD196_RS05965	COG0497	DNA recombination
CD196_RS05975	COG0456	acetyltransferase
CD196_RS05980	COG0456	acetyltransferase
CD196_RS05985	COG0750	zinc metalloprotease
CD196_RS06005	COG0463	Glycosyl transferase, family 2
CD196_RS06020	COG0494	nUDIX hydrolase
CD196_RS06030	COG4974	Belongs to the 'phage' integrase family
CD196_RS06035	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CD196_RS06040	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CD196_RS06050	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CD196_RS06055	COG4122	O-methyltransferase activity
CD196_RS06060	COG0826	peptidase U32
CD196_RS06065	COG0768	penicillin binding
CD196_RS06100	COG2801	Transposase and inactivated derivatives
CD196_RS06195	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CD196_RS06205	COG0571	ribonuclease III activity
CD196_RS06215	COG1196	nuclear chromosome segregation
CD196_RS06220	COG0552	protein localization to endoplasmic reticulum
CD196_RS06230	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CD196_RS06235	COG0228	four-way junction DNA binding
CD196_RS06245	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CD196_RS06250	COG0336	Belongs to the RNA methyltransferase TrmD family
CD196_RS06255	COG0335	large ribosomal subunit rRNA binding
CD196_RS06265	COG1114	Component of the transport system for branched-chain amino acids
CD196_RS06280	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CD196_RS06310	COG1131	(ABC) transporter
CD196_RS06315	COG2197	response regulator
CD196_RS06320	COG4585	Histidine kinase
CD196_RS06325	COG0792	nuclease activity
CD196_RS06330	COG0606	chelatase, subunit chli
CD196_RS06335	COG0758	DNA mediated transformation
CD196_RS06340	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CD196_RS06350	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CD196_RS06360	COG1959	2 iron, 2 sulfur cluster binding
CD196_RS06370	COG0822	iron-sulfur transferase activity
CD196_RS06375	COG0482	sulfurtransferase activity
CD196_RS06380	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CD196_RS06385	COG4472	Bacterial protein of unknown function (DUF965)
CD196_RS06395	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CD196_RS06400	COG3906	Belongs to the UPF0473 family
CD196_RS06405	COG0735	belongs to the Fur family
CD196_RS06415	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CD196_RS06425	COG1686	Belongs to the peptidase S11 family
CD196_RS06435	COG2207	Transcriptional regulator
CD196_RS06435	COG1917	Cupin 2, conserved barrel domain protein
CD196_RS06440	COG1994	Peptidase M50
CD196_RS06450	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CD196_RS06505	COG0779	Required for maturation of 30S ribosomal subunits
CD196_RS06510	COG0195	Participates in both transcription termination and antitermination
CD196_RS06515	COG2740	Nucleic-acid-binding protein implicated in transcription termination
CD196_RS06525	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CD196_RS06535	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CD196_RS06540	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CD196_RS06545	COG0196	riboflavin kinase activity
CD196_RS06555	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CD196_RS06560	COG1307	EDD domain protein, DegV family
CD196_RS06565	COG1185	polyribonucleotide nucleotidyltransferase activity
CD196_RS06570	COG0726	polysaccharide deacetylase
CD196_RS06575	COG0612	Peptidase, M16
CD196_RS06580	COG1873	PFAM PRC-barrel domain
CD196_RS06585	COG0527	aspartate kinase activity
CD196_RS06590	COG0740	serine-type endopeptidase activity
CD196_RS06600	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
CD196_RS06605	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CD196_RS06615	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CD196_RS06620	COG1418	mRNA catabolic process
CD196_RS06635	COG1968	undecaprenyl-diphosphatase activity
CD196_RS06645	COG0114	fumarate hydratase activity
CD196_RS06655	COG1263	PTS System
CD196_RS06655	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CD196_RS06665	COG1486	melibiose metabolic process
CD196_RS06670	COG0436	Aminotransferase
CD196_RS06680	COG0708	Exodeoxyribonuclease III
CD196_RS06695	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CD196_RS06720	COG1131	(ABC) transporter
CD196_RS06750	COG1278	Cold shock
CD196_RS06760	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CD196_RS06840	COG3299	homolog of phage Mu protein gp47
CD196_RS06845	COG3778	Protein conserved in bacteria
CD196_RS06890	COG1396	sequence-specific DNA binding
CD196_RS06895	COG2814	Major facilitator Superfamily
CD196_RS06905	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CD196_RS06910	COG0471	metal ion transport
CD196_RS06910	COG3273	potassium ion transport
CD196_RS06915	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CD196_RS06920	COG1914	H( )-stimulated, divalent metal cation uptake system
CD196_RS06925	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CD196_RS06930	COG1984	allophanate hydrolase subunit 2
CD196_RS06935	COG1396	sequence-specific DNA binding
CD196_RS06940	COG4948	Mandelate Racemase Muconate Lactonizing
CD196_RS06985	COG1473	amidohydrolase
CD196_RS06990	COG1619	proteins homologs of microcin C7 resistance protein MccF
CD196_RS07005	COG0584	glycerophosphoryl diester phosphodiesterase
CD196_RS07025	COG0488	(ABC) transporter
CD196_RS07035	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CD196_RS07040	COG1181	Belongs to the D-alanine--D-alanine ligase family
CD196_RS07045	COG1058	Belongs to the CinA family
CD196_RS07045	COG1546	Belongs to the CinA family
CD196_RS07060	COG3829	transcription factor binding
CD196_RS07070	COG1242	4 iron, 4 sulfur cluster binding
CD196_RS07100	COG2801	Transposase and inactivated derivatives
CD196_RS07105	COG5002	protein histidine kinase activity
CD196_RS07105	COG3447	MASE1 domain protein
CD196_RS07105	COG5001	Diguanylate cyclase
CD196_RS07110	COG2199	diguanylate cyclase activity
CD196_RS07110	COG2203	Gaf domain
CD196_RS07120	COG0789	Transcriptional regulator
CD196_RS07120	COG4978	Transcriptional regulator
CD196_RS07135	COG1285	pathogenesis
CD196_RS07140	COG1335	isochorismatase
CD196_RS07170	COG0726	polysaccharide deacetylase
CD196_RS07185	COG0450	alkyl hydroperoxide reductase
CD196_RS07200	COG2720	vancomycin resistance protein
CD196_RS07205	COG3829	transcription factor binding
CD196_RS07220	COG1346	cytolysis
CD196_RS07225	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CD196_RS07235	COG2340	Cysteine-rich secretory protein family
CD196_RS07240	COG0726	polysaccharide deacetylase
CD196_RS07245	COG0512	Glutamine amidotransferase of anthranilate synthase
CD196_RS07250	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CD196_RS07255	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CD196_RS07265	COG0302	gtp cyclohydrolase
CD196_RS07270	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CD196_RS07275	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CD196_RS07280	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CD196_RS07285	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CD196_RS07290	COG0358	DNA primase activity
CD196_RS07295	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CD196_RS07300	COG2384	SAM-dependent methyltransferase
CD196_RS07305	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CD196_RS07310	COG0655	NAD(P)H dehydrogenase (quinone) activity
CD196_RS07330	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CD196_RS07345	COG3850	Histidine kinase
CD196_RS07345	COG5002	protein histidine kinase activity
CD196_RS07350	COG0577	efflux transmembrane transporter activity
CD196_RS07350	COG1136	(ABC) transporter
CD196_RS07380	COG1132	(ABC) transporter
CD196_RS07385	COG1132	(ABC) transporter
CD196_RS07390	COG1592	Rubrerythrin
CD196_RS07390	COG1773	rubredoxin
CD196_RS07405	COG0412	Dienelactone hydrolase
CD196_RS07435	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CD196_RS07475	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CD196_RS07480	COG2011	ABC-type metal ion transport system permease component
CD196_RS07490	COG5002	protein histidine kinase activity
CD196_RS07495	COG2094	Belongs to the DNA glycosylase MPG family
CD196_RS07500	COG1396	sequence-specific DNA binding
CD196_RS07505	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CD196_RS07510	COG4086	secreted protein
CD196_RS07530	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CD196_RS07540	COG1131	(ABC) transporter
CD196_RS07550	COG0534	Mate efflux family protein
CD196_RS07565	COG3901	Regulator of nitric oxide reductase transcription
CD196_RS07565	COG0348	domain, Protein
CD196_RS07590	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CD196_RS07595	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CD196_RS07605	COG5001	Diguanylate cyclase
CD196_RS07615	COG4978	Transcriptional regulator
CD196_RS07615	COG0789	Transcriptional regulator
CD196_RS07620	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CD196_RS07640	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CD196_RS07645	COG0726	polysaccharide deacetylase
CD196_RS07655	COG1773	rubredoxin
CD196_RS07655	COG1592	Rubrerythrin
CD196_RS07660	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
CD196_RS07665	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CD196_RS07670	COG0577	efflux transmembrane transporter activity
CD196_RS07675	COG1136	(ABC) transporter
CD196_RS07675	COG0577	efflux transmembrane transporter activity
CD196_RS07685	COG2205	protein histidine kinase activity
CD196_RS07690	COG0745	RESPONSE REGULATOR receiver
CD196_RS07695	COG1136	(ABC) transporter
CD196_RS07700	COG0577	efflux transmembrane transporter activity
CD196_RS07705	COG0405	Gamma-glutamyltransferase
CD196_RS07720	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CD196_RS07720	COG0493	'glutamate synthase
CD196_RS07730	COG1136	(ABC) transporter
CD196_RS07735	COG0577	efflux transmembrane transporter activity
CD196_RS07775	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
CD196_RS07780	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CD196_RS07785	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CD196_RS07790	COG0131	Imidazoleglycerol-phosphate dehydratase
CD196_RS07795	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CD196_RS07800	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CD196_RS07805	COG0107	imidazoleglycerol-phosphate synthase activity
CD196_RS07810	COG0140	phosphoribosyl-ATP diphosphatase activity
CD196_RS07810	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CD196_RS07815	COG0531	amino acid
CD196_RS07830	COG1595	DNA-templated transcription, initiation
CD196_RS07845	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CD196_RS07860	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CD196_RS07865	COG0028	Belongs to the TPP enzyme family
CD196_RS07870	COG0582	viral genome integration into host DNA
CD196_RS08000	COG5484	DNA packaging
CD196_RS08135	COG4193	domain, Protein
CD196_RS08145	COG3628	GPW Gp25 family protein
CD196_RS08150	COG3299	homolog of phage Mu protein gp47
CD196_RS08200	COG1388	LysM domain
CD196_RS08200	COG0860	N-Acetylmuramoyl-L-alanine amidase
CD196_RS08215	COG3546	catalase activity
CD196_RS08220	COG1331	Highly conserved protein containing a thioredoxin domain
CD196_RS08240	COG2267	carboxylic ester hydrolase activity
CD196_RS08255	COG3584	3D domain protein
CD196_RS08255	COG1388	LysM domain
CD196_RS08265	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CD196_RS08270	COG1295	ribonuclease BN
CD196_RS08275	COG5002	protein histidine kinase activity
CD196_RS08280	COG0460	homoserine dehydrogenase
CD196_RS08290	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CD196_RS08295	COG2267	carboxylic ester hydrolase activity
CD196_RS08300	COG5566	PFAM Mor transcription activator
CD196_RS08310	COG2971	BadF BadG BcrA BcrD
CD196_RS08320	COG1129	ABC transporter
CD196_RS08325	COG1172	Belongs to the binding-protein-dependent transport system permease family
CD196_RS08335	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CD196_RS08340	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
CD196_RS08345	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CD196_RS08350	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CD196_RS08355	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CD196_RS08360	COG1045	serine acetyltransferase
CD196_RS08365	COG1141	Ferredoxin
CD196_RS08385	COG0351	phosphomethylpyrimidine kinase
CD196_RS08390	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
CD196_RS08395	COG0352	thiamine-phosphate diphosphorylase activity
CD196_RS08400	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CD196_RS08420	COG1725	Transcriptional regulator
CD196_RS08460	COG4555	ABC transporter
CD196_RS08465	COG1668	transmembrane transport
CD196_RS08470	COG5001	Diguanylate cyclase
CD196_RS08470	COG3300	MHYT domain
CD196_RS08475	COG1725	Transcriptional regulator
CD196_RS08480	COG1131	(ABC) transporter
CD196_RS08495	COG0668	transmembrane transport
CD196_RS08505	COG0426	domain, Protein
CD196_RS08520	COG1181	Belongs to the D-alanine--D-alanine ligase family
CD196_RS08525	COG1876	peptidase activity
CD196_RS08550	COG0367	asparagine synthase
CD196_RS08555	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CD196_RS08570	COG2310	stress, protein
CD196_RS08585	COG3853	Toxic anion resistance protein (TelA)
CD196_RS08615	COG5505	Protein of unknown function (DUF819)
CD196_RS08625	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CD196_RS08630	COG4605	iron ion homeostasis
CD196_RS08635	COG4604	ABC transporter, ATP-binding protein
CD196_RS08640	COG4607	ABC-type enterochelin transport system periplasmic component
CD196_RS08650	COG3706	GGDEF domain
CD196_RS08650	COG5001	Diguanylate cyclase
CD196_RS08650	COG2203	Gaf domain
CD196_RS08650	COG4251	negative regulation of phosphorylation
CD196_RS08665	COG0095	Lipoate-protein ligase
CD196_RS08670	COG1757	Na H antiporter
CD196_RS08680	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CD196_RS08685	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CD196_RS08690	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CD196_RS08695	COG3123	guanosine phosphorylase activity
CD196_RS08705	COG0402	S-adenosylhomocysteine deaminase activity
CD196_RS08715	COG1396	sequence-specific DNA binding
CD196_RS08725	COG0584	glycerophosphoryl diester phosphodiesterase
CD196_RS08745	COG4555	ABC transporter
CD196_RS08755	COG0745	RESPONSE REGULATOR receiver
CD196_RS08760	COG2205	protein histidine kinase activity
CD196_RS08775	COG1733	regulation of RNA biosynthetic process
CD196_RS08780	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
CD196_RS08810	COG1309	transcriptional regulator
CD196_RS08845	COG0745	RESPONSE REGULATOR receiver
CD196_RS08850	COG5002	protein histidine kinase activity
CD196_RS08855	COG3118	belongs to the thioredoxin family
CD196_RS08885	COG1115	amino acid carrier protein
CD196_RS08895	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CD196_RS08895	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CD196_RS08900	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CD196_RS08900	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CD196_RS08915	COG0514	ATP-dependent DNA helicase (RecQ)
CD196_RS08920	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CD196_RS08935	COG2022	thiamine diphosphate biosynthetic process
CD196_RS08940	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CD196_RS08950	COG1288	antiporter activity
CD196_RS08970	COG0393	Putative heavy-metal-binding
CD196_RS08975	COG0521	Mo-molybdopterin cofactor biosynthetic process
CD196_RS08985	COG0315	cyclic pyranopterin monophosphate synthase activity
CD196_RS09055	COG1283	sodium-dependent phosphate transmembrane transporter activity
CD196_RS09075	COG5012	cobalamin binding
CD196_RS09080	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CD196_RS09090	COG1011	Hydrolase
CD196_RS09095	COG1396	sequence-specific DNA binding
CD196_RS09095	COG1917	Cupin 2, conserved barrel domain protein
CD196_RS09100	COG2610	gluconate transmembrane transporter activity
CD196_RS09105	COG5002	protein histidine kinase activity
CD196_RS09110	COG2204	response regulator
CD196_RS09125	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
CD196_RS09135	COG0786	glutamate:sodium symporter activity
CD196_RS09150	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
CD196_RS09155	COG1924	4 iron, 4 sulfur cluster binding
CD196_RS09160	COG2247	cell wall binding repeat
CD196_RS09160	COG2385	sporulation resulting in formation of a cellular spore
CD196_RS09170	COG1309	transcriptional regulator
CD196_RS09195	COG0242	peptide deformylase activity
CD196_RS09230	COG3326	Membrane
CD196_RS09240	COG0494	nUDIX hydrolase
CD196_RS09285	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CD196_RS09290	COG0765	amino acid transport
CD196_RS09300	COG1393	Belongs to the ArsC family
CD196_RS09310	COG1606	tRNA processing
CD196_RS09315	COG0116	Belongs to the methyltransferase superfamily
CD196_RS09330	COG5002	protein histidine kinase activity
CD196_RS09330	COG3850	Histidine kinase
CD196_RS09340	COG0137	argininosuccinate synthase activity
CD196_RS09350	COG0789	Transcriptional regulator
CD196_RS09360	COG2323	membrane
CD196_RS09375	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CD196_RS09400	COG0446	pyridine nucleotide-disulphide oxidoreductase
CD196_RS09405	COG0583	DNA-binding transcription factor activity
CD196_RS09420	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CD196_RS09435	COG1609	Transcriptional regulator
CD196_RS09440	COG1621	beta-fructofuranosidase activity
CD196_RS09445	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CD196_RS09460	COG2814	Major facilitator Superfamily
CD196_RS09490	COG0406	alpha-ribazole phosphatase activity
CD196_RS09495	COG2081	HI0933 family
CD196_RS09500	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CD196_RS09505	COG0204	Acyl-transferase
CD196_RS09510	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CD196_RS09525	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CD196_RS09530	COG3022	response to hydroperoxide
CD196_RS09545	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
CD196_RS09550	COG1846	Transcriptional regulator
CD196_RS09555	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CD196_RS09560	COG2205	protein histidine kinase activity
CD196_RS09570	COG0598	Magnesium transport protein CorA
CD196_RS09580	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CD196_RS09585	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CD196_RS09590	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CD196_RS09595	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CD196_RS09600	COG0077	Prephenate dehydratase
CD196_RS09600	COG1605	Chorismate mutase
CD196_RS09605	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CD196_RS09615	COG0287	Prephenate dehydrogenase
CD196_RS09625	COG3706	GGDEF domain
CD196_RS09650	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CD196_RS09655	COG2226	methyltransferase
CD196_RS09660	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
CD196_RS09690	COG2131	deaminase
CD196_RS09705	COG0582	viral genome integration into host DNA
CD196_RS09715	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CD196_RS09760	COG4303	Ethanolamine ammonia lyase large subunit
CD196_RS09765	COG4302	ethanolamine ammonia-lyase activity
CD196_RS09780	COG1454	alcohol dehydrogenase
CD196_RS09780	COG1012	belongs to the aldehyde dehydrogenase family
CD196_RS09795	COG4869	propanediol catabolic process
CD196_RS09805	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
CD196_RS09815	COG3192	ethanolamine utilization protein
CD196_RS09820	COG4766	ethanolamine catabolic process
CD196_RS09830	COG1473	amidohydrolase
CD196_RS09835	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CD196_RS09840	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CD196_RS09845	COG1116	anion transmembrane transporter activity
CD196_RS09865	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CD196_RS09870	COG4974	Belongs to the 'phage' integrase family
CD196_RS09885	COG2359	stage V sporulation protein S
CD196_RS09890	COG0825	malonyl-CoA metabolic process
CD196_RS09895	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CD196_RS09900	COG0439	Biotin carboxylase
CD196_RS09905	COG0511	ligase activity, forming carbon-carbon bonds
CD196_RS09925	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CD196_RS09950	COG1136	(ABC) transporter
CD196_RS09960	COG2205	protein histidine kinase activity
CD196_RS09965	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CD196_RS09970	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CD196_RS09990	COG1136	(ABC) transporter
CD196_RS09995	COG2205	protein histidine kinase activity
CD196_RS10000	COG0745	RESPONSE REGULATOR receiver
CD196_RS10010	COG0745	RESPONSE REGULATOR receiver
CD196_RS10015	COG2205	protein histidine kinase activity
CD196_RS10020	COG1136	(ABC) transporter
CD196_RS10020	COG0577	efflux transmembrane transporter activity
CD196_RS10055	COG1811	Na channel or pump
CD196_RS10060	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
CD196_RS10075	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CD196_RS10080	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
CD196_RS10085	COG1923	regulation of RNA biosynthetic process
CD196_RS10090	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CD196_RS10095	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CD196_RS10100	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CD196_RS10105	COG1116	anion transmembrane transporter activity
CD196_RS10110	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CD196_RS10115	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CD196_RS10130	COG1733	regulation of RNA biosynthetic process
CD196_RS10140	COG0384	phenazine biosynthesis protein PhzF
CD196_RS10145	COG0494	nUDIX hydrolase
CD196_RS10155	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CD196_RS10160	COG2247	cell wall binding repeat
CD196_RS10160	COG0860	N-Acetylmuramoyl-L-alanine amidase
CD196_RS10220	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CD196_RS10240	COG0730	response to heat
CD196_RS10245	COG2207	Transcriptional regulator
CD196_RS10250	COG0789	Transcriptional regulator
CD196_RS10265	COG1404	Belongs to the peptidase S8 family
CD196_RS10270	COG0129	dihydroxy-acid dehydratase activity
CD196_RS10300	COG2207	Transcriptional regulator
CD196_RS10305	COG2814	Major facilitator Superfamily
CD196_RS10325	COG1725	Transcriptional regulator
CD196_RS10350	COG1794	racemase activity, acting on amino acids and derivatives
CD196_RS10360	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CD196_RS10365	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CD196_RS10370	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CD196_RS10375	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CD196_RS10385	COG0456	acetyltransferase
CD196_RS10395	COG1309	transcriptional regulator
CD196_RS10410	COG3655	Transcriptional regulator
CD196_RS10425	COG1737	Transcriptional regulator
CD196_RS10430	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
CD196_RS10435	COG1187	pseudouridine synthase activity
CD196_RS10440	COG0628	permease
CD196_RS10450	COG0019	diaminopimelate decarboxylase activity
CD196_RS10455	COG0527	aspartate kinase activity
CD196_RS10485	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CD196_RS10490	COG1597	lipid kinase activity
CD196_RS10520	COG0582	viral genome integration into host DNA
CD196_RS10530	COG0488	(ABC) transporter
CD196_RS10545	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CD196_RS10555	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CD196_RS10555	COG2080	2 iron, 2 sulfur cluster binding
CD196_RS10565	COG2233	PERMEase
CD196_RS10575	COG0167	dihydroorotate dehydrogenase activity
CD196_RS10580	COG0402	S-adenosylhomocysteine deaminase activity
CD196_RS10600	COG0402	S-adenosylhomocysteine deaminase activity
CD196_RS10625	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CD196_RS10650	COG3829	transcription factor binding
CD196_RS10660	COG1401	restriction endodeoxyribonuclease activity
CD196_RS10675	COG4708	membrane
CD196_RS10685	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CD196_RS10685	COG2080	2 iron, 2 sulfur cluster binding
CD196_RS10720	COG1131	(ABC) transporter
CD196_RS10730	COG2252	PERMEase
CD196_RS10735	COG0534	Mate efflux family protein
CD196_RS10745	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CD196_RS10750	COG1349	DNA-binding transcription factor activity
CD196_RS10760	COG5002	protein histidine kinase activity
CD196_RS10765	COG0745	RESPONSE REGULATOR receiver
CD196_RS10770	COG2217	Heavy metal translocating P-type atpase
CD196_RS10785	COG1217	gtp-binding protein TYPA
CD196_RS10790	COG0492	ferredoxin-NADP+ reductase activity
CD196_RS10830	COG1247	-acetyltransferase
CD196_RS10855	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CD196_RS10860	COG0750	zinc metalloprotease
CD196_RS10865	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CD196_RS10890	COG4589	Belongs to the CDS family
CD196_RS10905	COG0233	cytoplasmic translational termination
CD196_RS10910	COG0528	UMP kinase activity
CD196_RS10915	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CD196_RS10920	COG0052	Belongs to the universal ribosomal protein uS2 family
CD196_RS10925	COG1686	Belongs to the peptidase S11 family
CD196_RS10940	COG1971	Probably functions as a manganese efflux pump
CD196_RS10945	COG1193	negative regulation of DNA recombination
CD196_RS10960	COG2720	vancomycin resistance protein
CD196_RS10980	COG1363	Peptidase, m42
CD196_RS10990	COG1160	GTP binding
CD196_RS10995	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CD196_RS11045	COG0039	L-malate dehydrogenase activity
CD196_RS11055	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CD196_RS11055	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CD196_RS11065	COG1151	hydroxylamine reductase activity
CD196_RS11085	COG1301	dicarboxylic acid transport
CD196_RS11090	COG1126	abc transporter atp-binding protein
CD196_RS11115	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CD196_RS11120	COG0437	4 iron, 4 sulfur cluster binding
CD196_RS11130	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CD196_RS11135	COG0596	Alpha beta hydrolase
CD196_RS11140	COG0513	Belongs to the DEAD box helicase family
CD196_RS11165	COG1705	Flagellar rod assembly protein muramidase FlgJ
CD196_RS11170	COG1554	hydrolase, family 65, central catalytic
CD196_RS11175	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CD196_RS11185	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CD196_RS11195	COG2385	sporulation resulting in formation of a cellular spore
CD196_RS11195	COG2247	cell wall binding repeat
CD196_RS11205	COG1528	Iron-storage protein
CD196_RS11225	COG0674	pyruvate-flavodoxin oxidoreductase activity
CD196_RS11225	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CD196_RS11235	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CD196_RS11250	COG1309	transcriptional regulator
CD196_RS11260	COG0628	permease
CD196_RS11265	COG1012	belongs to the aldehyde dehydrogenase family
CD196_RS11280	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CD196_RS11305	COG0288	reversible hydration of carbon dioxide
CD196_RS11325	COG0710	3-dehydroquinate dehydratase activity
CD196_RS11335	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CD196_RS11395	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CD196_RS11400	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CD196_RS11405	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
CD196_RS11420	COG5001	Diguanylate cyclase
CD196_RS11420	COG3706	GGDEF domain
CD196_RS11420	COG4251	negative regulation of phosphorylation
CD196_RS11420	COG2203	Gaf domain
CD196_RS11425	COG0017	Asparaginyl-tRNA synthetase
CD196_RS11435	COG1404	Belongs to the peptidase S8 family
CD196_RS11440	COG1404	Belongs to the peptidase S8 family
CD196_RS11450	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CD196_RS11465	COG1509	lysine 2,3-aminomutase activity
CD196_RS11470	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CD196_RS11475	COG1794	racemase activity, acting on amino acids and derivatives
CD196_RS11495	COG0662	Cupin 2, conserved barrel domain protein
CD196_RS11505	COG0006	proline dipeptidase activity
CD196_RS11510	COG3104	oligopeptide transport
CD196_RS11515	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CD196_RS11530	COG0723	plastoquinol--plastocyanin reductase activity
CD196_RS11530	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CD196_RS11540	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CD196_RS11540	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CD196_RS11540	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CD196_RS11545	COG1105	Belongs to the carbohydrate kinase PfkB family
CD196_RS11550	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CD196_RS11550	COG3711	transcriptional antiterminator
CD196_RS11555	COG2365	Tyrosine phosphatase family
CD196_RS11575	COG1115	amino acid carrier protein
CD196_RS11580	COG0235	Class ii aldolase
CD196_RS11585	COG0235	Class ii aldolase
CD196_RS11590	COG1063	alcohol dehydrogenase
CD196_RS11595	COG3775	system Galactitol-specific IIC component
CD196_RS11600	COG3414	Phosphotransferase system galactitol-specific IIB component
CD196_RS11605	COG2213	PTS system mannitol-specific
CD196_RS11605	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CD196_RS11610	COG3933	PFAM sigma-54 factor interaction domain-containing protein
CD196_RS11610	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CD196_RS11630	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CD196_RS11635	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CD196_RS11645	COG5002	protein histidine kinase activity
CD196_RS11695	COG3620	sequence-specific DNA binding
CD196_RS11700	COG2801	Transposase and inactivated derivatives
CD196_RS11730	COG3842	ATPase activity
CD196_RS11750	COG2205	protein histidine kinase activity
CD196_RS11760	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CD196_RS11765	COG0698	ribose 5-phosphate isomerase
CD196_RS11770	COG3958	Transketolase
CD196_RS11775	COG3959	Transketolase, thiamine diphosphate binding domain
CD196_RS11790	COG3775	system Galactitol-specific IIC component
CD196_RS11795	COG3414	Phosphotransferase system galactitol-specific IIB component
CD196_RS11805	COG3933	PFAM sigma-54 factor interaction domain-containing protein
CD196_RS11805	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CD196_RS11810	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CD196_RS11815	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CD196_RS11820	COG0246	Mannitol dehydrogenase
CD196_RS11825	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CD196_RS11830	COG3711	transcriptional antiterminator
CD196_RS11840	COG0516	GMP reductase activity
CD196_RS11840	COG0517	IMP dehydrogenase activity
CD196_RS11845	COG3853	Toxic anion resistance protein (TelA)
CD196_RS11855	COG1454	alcohol dehydrogenase
CD196_RS11860	COG0427	acetyl-CoA hydrolase
CD196_RS11875	COG1012	belongs to the aldehyde dehydrogenase family
CD196_RS11880	COG0427	acetyl-CoA hydrolase
CD196_RS11885	COG0490	domain, Protein
CD196_RS11885	COG0490	domain, Protein
CD196_RS11885	COG2985	domain, Protein
CD196_RS11885	COG2985	domain, Protein
CD196_RS11890	COG0583	DNA-binding transcription factor activity
CD196_RS11900	COG0006	proline dipeptidase activity
CD196_RS11915	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
CD196_RS11940	COG3118	belongs to the thioredoxin family
CD196_RS11975	COG1116	anion transmembrane transporter activity
CD196_RS11985	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CD196_RS12025	COG0157	Belongs to the NadC ModD family
CD196_RS12035	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CD196_RS12040	COG1966	Carbon starvation protein
CD196_RS12055	COG0628	permease
CD196_RS12065	COG2364	Membrane
CD196_RS12070	COG3426	butyrate kinase activity
CD196_RS12095	COG2199	diguanylate cyclase activity
CD196_RS12100	COG2203	Gaf domain
CD196_RS12100	COG2199	diguanylate cyclase activity
CD196_RS12160	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CD196_RS12160	COG0072	phenylalanine-tRNA ligase activity
CD196_RS12165	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CD196_RS12170	COG2176	DNA-directed DNA polymerase activity
CD196_RS12190	COG0037	tRNA processing
CD196_RS12205	COG3546	catalase activity
CD196_RS12210	COG1388	LysM domain
CD196_RS12210	COG0791	NLP P60 protein
CD196_RS12210	COG3103	Sh3 type 3 domain protein
CD196_RS12220	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CD196_RS12220	COG0551	DNA topoisomerase type I activity
CD196_RS12245	COG2801	Transposase and inactivated derivatives
CD196_RS12260	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CD196_RS12260	COG0574	Belongs to the PEP-utilizing enzyme family
CD196_RS12265	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CD196_RS12270	COG0517	IMP dehydrogenase activity
CD196_RS12290	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CD196_RS12290	COG3711	transcriptional antiterminator
CD196_RS12295	COG3732	PTS system glucitol sorbitol-specific
CD196_RS12305	COG2207	Transcriptional regulator
CD196_RS12320	COG1115	amino acid carrier protein
CD196_RS12325	COG2223	nitrite transmembrane transporter activity
CD196_RS12330	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CD196_RS12335	COG0280	phosphate acetyltransferase
CD196_RS12355	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CD196_RS12355	COG0674	pyruvate-flavodoxin oxidoreductase activity
CD196_RS12365	COG1414	Transcriptional regulator
CD196_RS12375	COG0751	glycine-tRNA ligase activity
CD196_RS12380	COG0752	glycyl-tRNA synthetase alpha subunit
CD196_RS12390	COG1381	Involved in DNA repair and RecF pathway recombination
CD196_RS12400	COG2239	Acts as a magnesium transporter
CD196_RS12405	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CD196_RS12410	COG0295	cytidine deaminase activity
CD196_RS12415	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CD196_RS12420	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CD196_RS12425	COG1702	phosphate starvation-inducible protein PhoH
CD196_RS12445	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
CD196_RS12450	COG1610	YqeY-like protein
CD196_RS12455	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CD196_RS12460	COG0537	adenosine 5'-monophosphoramidase activity
CD196_RS12465	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CD196_RS12470	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CD196_RS12475	COG2264	protein methyltransferase activity
CD196_RS12505	COG3842	ATPase activity
CD196_RS12510	COG2508	Transcriptional regulator
CD196_RS12515	COG0477	Major facilitator Superfamily
CD196_RS12530	COG0484	heat shock protein binding
CD196_RS12535	COG0443	Heat shock 70 kDa protein
CD196_RS12540	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CD196_RS12545	COG1420	regulation of RNA biosynthetic process
CD196_RS12550	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CD196_RS12555	COG0531	amino acid
CD196_RS12560	COG0617	tRNA 3'-terminal CCA addition
CD196_RS12565	COG0481	GTPase activity
CD196_RS12595	COG0268	Binds directly to 16S ribosomal RNA
CD196_RS12605	COG2333	competence protein COMEC
CD196_RS12605	COG0658	competence protein
CD196_RS12625	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CD196_RS12630	COG3584	3D domain protein
CD196_RS12630	COG1388	LysM domain
CD196_RS12635	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CD196_RS12650	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CD196_RS12655	COG0006	proline dipeptidase activity
CD196_RS12660	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CD196_RS12665	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CD196_RS12675	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CD196_RS12675	COG3711	transcriptional antiterminator
CD196_RS12680	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CD196_RS12685	COG1482	cell wall glycoprotein biosynthetic process
CD196_RS12690	COG5002	protein histidine kinase activity
CD196_RS12705	COG0709	Synthesizes selenophosphate from selenide and ATP
CD196_RS12710	COG1555	photosystem II stabilization
CD196_RS12715	COG1686	Belongs to the peptidase S11 family
CD196_RS12725	COG0165	Argininosuccinate lyase
CD196_RS12735	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CD196_RS12740	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CD196_RS12745	COG1876	peptidase activity
CD196_RS12750	COG1309	transcriptional regulator
CD196_RS12755	COG2814	Major facilitator Superfamily
CD196_RS12765	COG4977	sequence-specific DNA binding
CD196_RS12770	COG1486	melibiose metabolic process
CD196_RS12775	COG1263	PTS System
CD196_RS12775	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CD196_RS12780	COG3711	transcriptional antiterminator
CD196_RS12785	COG2190	(PTS) system
CD196_RS12790	COG0251	oxidation-reduction process
CD196_RS12795	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CD196_RS12815	COG0495	leucyl-tRNA aminoacylation
CD196_RS12820	COG0799	negative regulation of ribosome biogenesis
CD196_RS12825	COG1713	HD superfamily hydrolase involved in NAD metabolism
CD196_RS12830	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CD196_RS12840	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CD196_RS12860	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CD196_RS12870	COG1136	(ABC) transporter
CD196_RS12870	COG0577	efflux transmembrane transporter activity
CD196_RS12880	COG0745	RESPONSE REGULATOR receiver
CD196_RS12885	COG0737	Belongs to the 5'-nucleotidase family
CD196_RS12895	COG1234	tRNA 3'-trailer cleavage
CD196_RS12900	COG0446	pyridine nucleotide-disulphide oxidoreductase
CD196_RS12930	COG4124	Belongs to the glycosyl hydrolase 26 family
CD196_RS12930	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
CD196_RS12940	COG0395	ABC-type sugar transport system, permease component
CD196_RS12955	COG4821	SIS domain
CD196_RS12985	COG0742	ribosomal rna small subunit methyltransferase
CD196_RS12990	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CD196_RS12995	COG1461	Dihydroxyacetone kinase
CD196_RS13000	COG1302	Protein conserved in bacteria
CD196_RS13005	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CD196_RS13020	COG0789	Transcriptional regulator
CD196_RS13025	COG3711	transcriptional antiterminator
CD196_RS13025	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CD196_RS13030	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CD196_RS13030	COG3711	transcriptional antiterminator
CD196_RS13035	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CD196_RS13040	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CD196_RS13045	COG0383	alpha-mannosidase activity
CD196_RS13070	COG1564	THIamine pyrophosphokinase
CD196_RS13075	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CD196_RS13080	COG1162	GTPase activity
CD196_RS13085	COG1028	Short-chain dehydrogenase reductase Sdr
CD196_RS13090	COG2815	serine threonine protein kinase
CD196_RS13090	COG0515	serine threonine protein kinase
CD196_RS13100	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CD196_RS13105	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CD196_RS13105	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CD196_RS13110	COG2738	Putative neutral zinc metallopeptidase
CD196_RS13120	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CD196_RS13125	COG0242	peptide deformylase activity
CD196_RS13130	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CD196_RS13135	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CD196_RS13140	COG1758	RNA polymerase activity
CD196_RS13145	COG0194	GDP metabolic process
CD196_RS13150	COG1561	YicC-like family, N-terminal region
CD196_RS13155	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CD196_RS13165	COG1293	RNA-binding protein homologous to eukaryotic snRNP
CD196_RS13170	COG0488	(ABC) transporter
CD196_RS13180	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CD196_RS13185	COG0564	pseudouridine synthase activity
CD196_RS13190	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CD196_RS13200	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CD196_RS13205	COG1966	Carbon starvation protein
CD196_RS13210	COG3279	Response regulator of the LytR AlgR family
CD196_RS13215	COG3275	phosphorelay sensor kinase activity
CD196_RS13240	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CD196_RS13245	COG0531	amino acid
CD196_RS13250	COG0006	proline dipeptidase activity
CD196_RS13255	COG1307	EDD domain protein, DegV family
CD196_RS13270	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CD196_RS13280	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CD196_RS13290	COG2302	S4 RNA-binding domain
CD196_RS13300	COG1799	cell septum assembly
CD196_RS13305	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CD196_RS13325	COG3830	Belongs to the UPF0237 family
CD196_RS13335	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CD196_RS13340	COG2271	Major facilitator Superfamily
CD196_RS13345	COG0531	amino acid
CD196_RS13350	COG0006	proline dipeptidase activity
CD196_RS13360	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CD196_RS13365	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CD196_RS13370	COG1160	GTP binding
CD196_RS13395	COG5002	protein histidine kinase activity
CD196_RS13400	COG0745	RESPONSE REGULATOR receiver
CD196_RS13410	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CD196_RS13415	COG1873	PFAM PRC-barrel domain
CD196_RS13420	COG1191	sigma factor activity
CD196_RS13425	COG1191	sigma factor activity
CD196_RS13440	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CD196_RS13445	COG3856	small basic protein
CD196_RS13465	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CD196_RS13470	COG0772	Belongs to the SEDS family
CD196_RS13475	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CD196_RS13480	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CD196_RS13485	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CD196_RS13490	COG0768	penicillin binding
CD196_RS13500	COG0275	rRNA processing
CD196_RS13505	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CD196_RS13510	COG0612	Peptidase, M16
CD196_RS13520	COG0012	GTP binding
CD196_RS13530	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CD196_RS13540	COG1263	PTS System
CD196_RS13540	COG2190	(PTS) system
CD196_RS13540	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CD196_RS13545	COG3711	transcriptional antiterminator
CD196_RS13550	COG0025	NhaP-type Na H and K H
CD196_RS13555	COG4608	Belongs to the ABC transporter superfamily
CD196_RS13560	COG0444	Belongs to the ABC transporter superfamily
CD196_RS13570	COG0601	transmembrane transport
CD196_RS13575	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CD196_RS13580	COG0583	DNA-binding transcription factor activity
CD196_RS13585	COG0183	Belongs to the thiolase family
CD196_RS13590	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CD196_RS13600	COG1028	Short-chain dehydrogenase reductase Sdr
CD196_RS13605	COG2610	gluconate transmembrane transporter activity
CD196_RS13610	COG2340	Cysteine-rich secretory protein family
CD196_RS13620	COG4869	propanediol catabolic process
CD196_RS13655	COG2081	HI0933 family
CD196_RS13660	COG0671	phosphoesterase, PA-phosphatase related
CD196_RS13670	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CD196_RS13685	COG2502	aspartate--ammonia ligase
CD196_RS13690	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CD196_RS13695	COG1473	amidohydrolase
CD196_RS13705	COG3366	ferrous iron transmembrane transporter activity
CD196_RS13730	COG2252	PERMEase
CD196_RS13735	COG0402	S-adenosylhomocysteine deaminase activity
CD196_RS13745	COG2271	Major facilitator Superfamily
CD196_RS13765	COG0583	DNA-binding transcription factor activity
CD196_RS13775	COG1376	ErfK ybiS ycfS ynhG family protein
CD196_RS13780	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CD196_RS13785	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CD196_RS13805	COG4509	Sortase family
CD196_RS13825	COG0726	polysaccharide deacetylase
CD196_RS13830	COG3069	C4-dicarboxylate transmembrane transporter activity
CD196_RS13835	COG0642	Histidine kinase
CD196_RS13835	COG5002	protein histidine kinase activity
CD196_RS13840	COG0745	RESPONSE REGULATOR receiver
CD196_RS13855	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CD196_RS13860	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CD196_RS13880	COG1937	Protein conserved in bacteria
CD196_RS13895	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CD196_RS13900	COG1757	Na H antiporter
CD196_RS13910	COG2247	cell wall binding repeat
CD196_RS13910	COG0860	N-Acetylmuramoyl-L-alanine amidase
CD196_RS13915	COG0583	DNA-binding transcription factor activity
CD196_RS13920	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CD196_RS13930	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CD196_RS13935	COG0124	histidyl-tRNA synthetase
CD196_RS13940	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CD196_RS13945	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CD196_RS13950	COG1490	D-aminoacyl-tRNA deacylase activity
CD196_RS13955	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CD196_RS13960	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CD196_RS13965	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CD196_RS13965	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CD196_RS14010	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CD196_RS14035	COG0860	N-Acetylmuramoyl-L-alanine amidase
CD196_RS14040	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CD196_RS14050	COG0561	phosphatase activity
CD196_RS14055	COG1316	TRANSCRIPTIONal
CD196_RS14060	COG1316	TRANSCRIPTIONal
CD196_RS14065	COG1649	PFAM Uncharacterised BCR, COG1649
CD196_RS14070	COG0791	NLP P60 protein
CD196_RS14080	COG0438	transferase activity, transferring glycosyl groups
CD196_RS14085	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CD196_RS14090	COG1215	transferase activity, transferring glycosyl groups
CD196_RS14100	COG1215	transferase activity, transferring glycosyl groups
CD196_RS14105	COG1215	transferase activity, transferring glycosyl groups
CD196_RS14105	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CD196_RS14110	COG1215	transferase activity, transferring glycosyl groups
CD196_RS14130	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CD196_RS14135	COG0728	peptidoglycan biosynthetic process
CD196_RS14140	COG2247	cell wall binding repeat
CD196_RS14140	COG0860	N-Acetylmuramoyl-L-alanine amidase
CD196_RS14145	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CD196_RS14150	COG0860	N-Acetylmuramoyl-L-alanine amidase
CD196_RS14160	COG2247	cell wall binding repeat
CD196_RS14160	COG0860	N-Acetylmuramoyl-L-alanine amidase
CD196_RS14170	COG2246	polysaccharide biosynthetic process
CD196_RS14175	COG2247	cell wall binding repeat
CD196_RS14175	COG0860	N-Acetylmuramoyl-L-alanine amidase
CD196_RS14190	COG0653	protein targeting
CD196_RS14225	COG0860	N-Acetylmuramoyl-L-alanine amidase
CD196_RS14225	COG2247	cell wall binding repeat
CD196_RS14245	COG0343	queuine tRNA-ribosyltransferase activity
CD196_RS14255	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CD196_RS14260	COG2255	four-way junction helicase activity
CD196_RS14265	COG0632	four-way junction helicase activity
CD196_RS14270	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CD196_RS14295	COG2610	gluconate transmembrane transporter activity
CD196_RS14300	COG2084	Dehydrogenase
CD196_RS14320	COG1132	(ABC) transporter
CD196_RS14335	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CD196_RS14345	COG2801	Transposase and inactivated derivatives
CD196_RS14355	COG0700	Nucleoside recognition
CD196_RS14360	COG3366	ferrous iron transmembrane transporter activity
CD196_RS14365	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CD196_RS14405	COG0436	Aminotransferase
CD196_RS14410	COG0697	spore germination
CD196_RS14425	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CD196_RS14440	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CD196_RS14445	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CD196_RS14450	COG1473	amidohydrolase
CD196_RS14455	COG3949	Membrane
CD196_RS14470	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CD196_RS14485	COG0604	alcohol dehydrogenase
CD196_RS14495	COG1592	Rubrerythrin
CD196_RS14500	COG0789	Transcriptional regulator
CD196_RS14510	COG1664	Polymer-forming cytoskeletal
CD196_RS14515	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CD196_RS14515	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CD196_RS14520	COG1349	DNA-binding transcription factor activity
CD196_RS14525	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CD196_RS14530	COG1696	Membrane protein involved in D-alanine export
CD196_RS14535	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CD196_RS14545	COG0673	inositol 2-dehydrogenase activity
CD196_RS14555	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CD196_RS14560	COG1253	flavin adenine dinucleotide binding
CD196_RS14565	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
CD196_RS14585	COG3290	protein histidine kinase activity
CD196_RS14585	COG3829	transcription factor binding
CD196_RS14590	COG2267	carboxylic ester hydrolase activity
CD196_RS14600	COG0577	efflux transmembrane transporter activity
CD196_RS14605	COG1136	(ABC) transporter
CD196_RS14620	COG0745	RESPONSE REGULATOR receiver
CD196_RS14625	COG0312	modulator of DNA gyrase
CD196_RS14630	COG0312	modulator of DNA gyrase
CD196_RS14655	COG2721	sulfolactate sulfo-lyase activity
CD196_RS14670	COG1120	ATPase activity
CD196_RS14675	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CD196_RS14680	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CD196_RS14695	COG1447	Phosphotransferase system cellobiose-specific component IIA
CD196_RS14700	COG3394	polysaccharide catabolic process
CD196_RS14705	COG1486	melibiose metabolic process
CD196_RS14710	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CD196_RS14720	COG2188	Transcriptional regulator
CD196_RS14725	COG0534	Mate efflux family protein
CD196_RS14730	COG2199	diguanylate cyclase activity
CD196_RS14735	COG1178	ABC-type Fe3 transport system permease component
CD196_RS14740	COG3842	ATPase activity
CD196_RS14745	COG1840	ABC-type Fe3 transport system, periplasmic component
CD196_RS14750	COG1394	ATPase activity, coupled to movement of substances
CD196_RS14755	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
CD196_RS14760	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
CD196_RS14775	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
CD196_RS14780	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CD196_RS14785	COG1269	ATP hydrolysis coupled proton transport
CD196_RS14810	COG5001	Diguanylate cyclase
CD196_RS14810	COG3300	MHYT domain
CD196_RS14815	COG1454	alcohol dehydrogenase
CD196_RS14815	COG1012	belongs to the aldehyde dehydrogenase family
CD196_RS14825	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CD196_RS14835	COG0318	PFAM AMP-dependent synthetase and ligase
CD196_RS14840	COG0183	Belongs to the thiolase family
CD196_RS14845	COG1268	BioY protein
CD196_RS14860	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CD196_RS14875	COG1203	CRISPR-associated helicase, Cas3
CD196_RS14905	COG0577	efflux transmembrane transporter activity
CD196_RS14910	COG1136	(ABC) transporter
CD196_RS14915	COG1968	undecaprenyl-diphosphatase activity
CD196_RS14920	COG2205	protein histidine kinase activity
CD196_RS14925	COG0745	RESPONSE REGULATOR receiver
CD196_RS14940	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CD196_RS14955	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CD196_RS14960	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CD196_RS14970	COG1120	ATPase activity
CD196_RS14975	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CD196_RS14985	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CD196_RS14995	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CD196_RS15000	COG0179	Fumarylacetoacetate (FAA) hydrolase
CD196_RS15025	COG1454	alcohol dehydrogenase
CD196_RS15040	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CD196_RS15045	COG0785	Cytochrome C biogenesis protein
CD196_RS15050	COG1733	regulation of RNA biosynthetic process
CD196_RS15055	COG0383	alpha-mannosidase activity
CD196_RS15060	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CD196_RS15065	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CD196_RS15070	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CD196_RS15070	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CD196_RS15070	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CD196_RS15075	COG3711	transcriptional antiterminator
CD196_RS15075	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CD196_RS15080	COG4975	Glucose uptake
CD196_RS15115	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CD196_RS15130	COG0517	IMP dehydrogenase activity
CD196_RS15130	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CD196_RS15135	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CD196_RS15140	COG1263	PTS System
CD196_RS15140	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CD196_RS15145	COG3711	transcriptional antiterminator
CD196_RS15150	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CD196_RS15155	COG3118	belongs to the thioredoxin family
CD196_RS15165	COG0384	phenazine biosynthesis protein PhzF
CD196_RS15185	COG0542	response to heat
CD196_RS15195	COG2267	carboxylic ester hydrolase activity
CD196_RS15210	COG1737	Transcriptional regulator
CD196_RS15215	COG2971	BadF BadG BcrA BcrD
CD196_RS15220	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CD196_RS15230	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CD196_RS15245	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CD196_RS15250	COG0642	Histidine kinase
CD196_RS15265	COG1136	(ABC) transporter
CD196_RS15275	COG2190	(PTS) system
CD196_RS15290	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CD196_RS15290	COG1263	PTS System
CD196_RS15305	COG2115	Belongs to the xylose isomerase family
CD196_RS15310	COG1070	Carbohydrate kinase
CD196_RS15325	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CD196_RS15325	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CD196_RS15330	COG3716	PTS system mannose fructose sorbose family IID component
CD196_RS15360	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
CD196_RS15385	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CD196_RS15390	COG0191	fructose-bisphosphate aldolase activity
CD196_RS15395	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CD196_RS15395	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CD196_RS15395	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CD196_RS15410	COG2364	Membrane
CD196_RS15415	COG2723	6-phospho-beta-galactosidase activity
CD196_RS15425	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CD196_RS15430	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CD196_RS15435	COG2213	PTS system mannitol-specific
CD196_RS15435	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CD196_RS15440	COG1929	Belongs to the glycerate kinase type-1 family
CD196_RS15445	COG0383	alpha-mannosidase activity
CD196_RS15450	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CD196_RS15450	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CD196_RS15450	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CD196_RS15460	COG3394	polysaccharide catabolic process
CD196_RS15465	COG2190	(PTS) system
CD196_RS15465	COG1263	PTS System
CD196_RS15465	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CD196_RS15470	COG2188	Transcriptional regulator
CD196_RS15475	COG0366	Alpha amylase catalytic
CD196_RS15485	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CD196_RS15500	COG2723	6-phospho-beta-galactosidase activity
CD196_RS15505	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CD196_RS15505	COG2190	(PTS) system
CD196_RS15505	COG1263	PTS System
CD196_RS15510	COG3711	transcriptional antiterminator
CD196_RS15520	COG1288	antiporter activity
CD196_RS15525	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CD196_RS15525	COG1263	PTS System
CD196_RS15530	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CD196_RS15540	COG0561	phosphatase activity
CD196_RS15545	COG1454	alcohol dehydrogenase
CD196_RS15550	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CD196_RS15555	COG3711	transcriptional antiterminator
CD196_RS15555	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CD196_RS15560	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CD196_RS15565	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CD196_RS15570	COG0205	6-phosphofructokinase activity
CD196_RS15590	COG1473	amidohydrolase
CD196_RS15595	COG1473	amidohydrolase
CD196_RS15605	COG2723	6-phospho-beta-galactosidase activity
CD196_RS15610	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CD196_RS15610	COG1263	PTS System
CD196_RS15610	COG2190	(PTS) system
CD196_RS15625	COG1819	glycosyl
CD196_RS15670	COG2223	nitrite transmembrane transporter activity
CD196_RS15675	COG1695	Transcriptional regulator
CD196_RS15685	COG0640	Transcriptional regulator
CD196_RS15695	COG2723	6-phospho-beta-galactosidase activity
CD196_RS15700	COG1263	PTS System
CD196_RS15700	COG2190	(PTS) system
CD196_RS15700	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CD196_RS15705	COG3711	transcriptional antiterminator
CD196_RS15710	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CD196_RS15710	COG1263	PTS System
CD196_RS15715	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CD196_RS15725	COG2723	6-phospho-beta-galactosidase activity
CD196_RS15735	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CD196_RS15735	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CD196_RS15735	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CD196_RS15740	COG3711	transcriptional antiterminator
CD196_RS15745	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CD196_RS15745	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CD196_RS15745	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CD196_RS15750	COG0191	fructose-bisphosphate aldolase activity
CD196_RS15755	COG1178	ABC-type Fe3 transport system permease component
CD196_RS15760	COG3842	ATPase activity
CD196_RS15770	COG1840	ABC-type Fe3 transport system, periplasmic component
CD196_RS15785	COG0693	protein deglycase activity
CD196_RS15900	COG0305	Participates in initiation and elongation during chromosome replication
CD196_RS15920	COG3620	sequence-specific DNA binding
CD196_RS15940	COG0582	viral genome integration into host DNA
CD196_RS15965	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CD196_RS15990	COG1131	(ABC) transporter
CD196_RS16000	COG0557	exoribonuclease II activity
CD196_RS16015	COG1881	PFAM PEBP family protein
CD196_RS16045	COG0148	phosphopyruvate hydratase activity
CD196_RS16050	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CD196_RS16055	COG0149	triose-phosphate isomerase activity
CD196_RS16060	COG0126	phosphoglycerate kinase activity
CD196_RS16070	COG2390	Transcriptional regulator
CD196_RS16075	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CD196_RS16080	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CD196_RS16090	COG0167	dihydroorotate dehydrogenase activity
CD196_RS16100	COG0402	S-adenosylhomocysteine deaminase activity
CD196_RS16105	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
CD196_RS16125	COG3829	transcription factor binding
CD196_RS16130	COG0251	oxidation-reduction process
CD196_RS16145	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CD196_RS16150	COG0789	Transcriptional regulator
CD196_RS16160	COG2247	cell wall binding repeat
CD196_RS16160	COG0860	N-Acetylmuramoyl-L-alanine amidase
CD196_RS16165	COG1136	(ABC) transporter
CD196_RS16170	COG0577	efflux transmembrane transporter activity
CD196_RS16190	COG2207	Transcriptional regulator
CD196_RS16195	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CD196_RS16205	COG0789	Transcriptional regulator
CD196_RS16230	COG2205	protein histidine kinase activity
CD196_RS16230	COG2770	Histidine kinase
CD196_RS16235	COG0745	RESPONSE REGULATOR receiver
CD196_RS16240	COG0706	membrane insertase activity
CD196_RS16250	COG0778	Nitroreductase
CD196_RS16255	COG0534	Mate efflux family protein
CD196_RS16280	COG2226	methyltransferase
CD196_RS16305	COG1732	Glycine betaine
CD196_RS16310	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CD196_RS16320	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CD196_RS16325	COG2226	methyltransferase
CD196_RS16335	COG1473	amidohydrolase
CD196_RS16340	COG1760	l-serine dehydratase
CD196_RS16350	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CD196_RS16355	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CD196_RS16360	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CD196_RS16365	COG2171	N-acyltransferase activity
CD196_RS16375	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CD196_RS16385	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CD196_RS16390	COG3681	Belongs to the UPF0597 family
CD196_RS16395	COG3829	transcription factor binding
CD196_RS16400	COG2226	methyltransferase
CD196_RS16425	COG5275	peptidyl-tyrosine sulfation
CD196_RS16425	COG0252	asparaginase activity
CD196_RS16430	COG0252	asparaginase activity
CD196_RS16430	COG5275	peptidyl-tyrosine sulfation
CD196_RS16435	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
CD196_RS16440	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
CD196_RS16450	COG5275	peptidyl-tyrosine sulfation
CD196_RS16450	COG0252	asparaginase activity
CD196_RS16460	COG4656	Part of a membrane complex involved in electron transport
CD196_RS16470	COG0726	polysaccharide deacetylase
CD196_RS16495	COG0285	dihydrofolate synthase activity
CD196_RS16505	COG3279	Response regulator of the LytR AlgR family
CD196_RS16510	COG0525	valine-tRNA ligase activity
CD196_RS16515	COG0726	polysaccharide deacetylase
CD196_RS16530	COG0704	Plays a role in the regulation of phosphate uptake
CD196_RS16535	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CD196_RS16540	COG0581	inorganic phosphate transmembrane transporter activity
CD196_RS16545	COG0573	inorganic phosphate transmembrane transporter activity
CD196_RS16555	COG1131	(ABC) transporter
CD196_RS16580	COG0745	RESPONSE REGULATOR receiver
CD196_RS16585	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CD196_RS16590	COG1164	Oligoendopeptidase f
CD196_RS16595	COG1285	pathogenesis
CD196_RS16615	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CD196_RS16620	COG3716	PTS system mannose fructose sorbose family IID component
CD196_RS16625	COG3715	PTS system
CD196_RS16630	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CD196_RS16630	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CD196_RS16645	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CD196_RS16660	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CD196_RS16665	COG0166	Belongs to the GPI family
CD196_RS16670	COG1283	sodium-dependent phosphate transmembrane transporter activity
CD196_RS16675	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
CD196_RS16690	COG1405	negative regulation of cell septum assembly
CD196_RS16690	COG3012	SEC-C Motif Domain Protein
CD196_RS16715	COG1459	type II secretion system
CD196_RS16720	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CD196_RS16735	COG2814	Major facilitator Superfamily
CD196_RS16740	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CD196_RS16745	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CD196_RS16755	COG2059	Chromate
CD196_RS16760	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CD196_RS16765	COG0740	serine-type endopeptidase activity
CD196_RS16770	COG0544	peptidyl-prolyl cis-trans isomerase activity
CD196_RS16785	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CD196_RS16805	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CD196_RS16805	COG0493	'glutamate synthase
CD196_RS16815	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CD196_RS16825	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CD196_RS16830	COG3383	formate dehydrogenase (NAD+) activity
CD196_RS16835	COG3383	formate dehydrogenase (NAD+) activity
CD196_RS16865	COG1131	(ABC) transporter
CD196_RS16885	COG3279	Response regulator of the LytR AlgR family
CD196_RS16915	COG0463	Glycosyl transferase, family 2
CD196_RS16915	COG0457	Tetratricopeptide repeat
CD196_RS16930	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CD196_RS16940	COG0778	Nitroreductase
CD196_RS16945	COG1733	regulation of RNA biosynthetic process
CD196_RS16950	COG0693	protein deglycase activity
CD196_RS16955	COG1522	sequence-specific DNA binding
CD196_RS16965	COG0488	(ABC) transporter
CD196_RS16970	COG0745	RESPONSE REGULATOR receiver
CD196_RS16990	COG4555	ABC transporter
CD196_RS16995	COG2199	diguanylate cyclase activity
CD196_RS17040	COG0205	6-phosphofructokinase activity
CD196_RS17050	COG1481	regulation of sporulation
CD196_RS17065	COG1660	Displays ATPase and GTPase activities
CD196_RS17075	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CD196_RS17080	COG2116	formate transmembrane transporter activity
CD196_RS17085	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CD196_RS17115	COG0322	excinuclease ABC activity
CD196_RS17125	COG0556	nucleotide-excision repair
CD196_RS17135	COG1653	transport
CD196_RS17145	COG1175	transmembrane transport
CD196_RS17150	COG3842	ATPase activity
CD196_RS17170	COG1648	precorrin-2 dehydrogenase activity
CD196_RS17170	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CD196_RS17175	COG0113	porphobilinogen synthase activity
CD196_RS17185	COG0181	hydroxymethylbilane synthase activity
CD196_RS17195	COG2099	Precorrin-6x reductase
CD196_RS17225	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
CD196_RS17240	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CD196_RS17250	COG1797	cobyrinic acid a,c-diamide synthase activity
CD196_RS17255	COG1492	cobalamin metabolic process
CD196_RS17260	COG0406	alpha-ribazole phosphatase activity
CD196_RS17265	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CD196_RS17270	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
CD196_RS17275	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CD196_RS17295	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CD196_RS17310	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CD196_RS17315	COG1447	Phosphotransferase system cellobiose-specific component IIA
CD196_RS17320	COG1363	Peptidase, m42
CD196_RS17325	COG3711	transcriptional antiterminator
CD196_RS17330	COG0191	fructose-bisphosphate aldolase activity
CD196_RS17335	COG2222	sugar isomerase
CD196_RS17350	COG2188	Transcriptional regulator
CD196_RS17390	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CD196_RS17455	COG3328	transposase activity
CD196_RS17460	COG3409	Peptidoglycan-binding domain 1 protein
CD196_RS17460	COG0793	Belongs to the peptidase S41A family
CD196_RS17465	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CD196_RS17475	COG3949	Membrane
CD196_RS17480	COG3958	Transketolase
CD196_RS17485	COG3959	Transketolase, thiamine diphosphate binding domain
CD196_RS17490	COG2337	Toxic component of a toxin-antitoxin (TA) module
CD196_RS17510	COG0516	GMP reductase activity
CD196_RS17510	COG0517	IMP dehydrogenase activity
CD196_RS17515	COG0736	holo-[acyl-carrier-protein] synthase activity
CD196_RS17520	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CD196_RS17525	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CD196_RS17530	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CD196_RS17535	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CD196_RS17540	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CD196_RS17545	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CD196_RS17550	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CD196_RS17575	COG3608	succinylglutamate desuccinylase aspartoacylase
CD196_RS17575	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CD196_RS17580	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CD196_RS17585	COG0698	ribose 5-phosphate isomerase
CD196_RS17595	COG0009	L-threonylcarbamoyladenylate synthase
CD196_RS17605	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CD196_RS17610	COG2890	protein-(glutamine-N5) methyltransferase activity
CD196_RS17615	COG3872	metal-dependent enzyme
CD196_RS17620	COG0254	rRNA binding
CD196_RS17625	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CD196_RS17630	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CD196_RS17640	COG2208	phosphoserine phosphatase activity
CD196_RS17645	COG0248	Ppx GppA phosphatase
CD196_RS17665	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CD196_RS17675	COG3956	TIGRFAM MazG family protein
CD196_RS17680	COG2244	polysaccharide biosynthetic process
CD196_RS17685	COG2002	toxin-antitoxin pair type II binding
CD196_RS17690	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CD196_RS17695	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CD196_RS17700	COG0193	aminoacyl-tRNA hydrolase activity
CD196_RS17750	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CD196_RS17765	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CD196_RS17770	COG2088	sporulation resulting in formation of a cellular spore
CD196_RS17775	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CD196_RS17780	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CD196_RS17790	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CD196_RS17795	COG2195	Cleaves the N-terminal amino acid of tripeptides
CD196_RS17805	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CD196_RS17810	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
CD196_RS17815	COG1840	ABC-type Fe3 transport system, periplasmic component
CD196_RS17825	COG1840	ABC-type Fe3 transport system, periplasmic component
CD196_RS17835	COG3842	ATPase activity
CD196_RS17840	COG0613	PHP domain protein
CD196_RS17845	COG3454	Phosphonate metabolism
CD196_RS17850	COG4778	phosphonate C-P lyase system protein PhnL
CD196_RS17855	COG4107	phosphonate C-P lyase system protein PhnK
CD196_RS17860	COG3627	carbon phosphorus lyase activity
CD196_RS17880	COG0084	hydrolase, TatD family'
CD196_RS17885	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CD196_RS17885	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CD196_RS17890	COG0700	Nucleoside recognition
CD196_RS17900	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CD196_RS17905	COG1522	sequence-specific DNA binding
CD196_RS17910	COG0617	tRNA 3'-terminal CCA addition
CD196_RS17915	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CD196_RS17920	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CD196_RS17925	COG1774	PSP1 C-terminal conserved region
CD196_RS17930	COG0470	DNA polymerase III
CD196_RS17935	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CD196_RS17940	COG1982	Orn Lys Arg decarboxylase major
CD196_RS17945	COG2155	Conserved Protein
CD196_RS17970	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CD196_RS17975	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CD196_RS17985	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CD196_RS17995	COG3191	aminopeptidase activity
CD196_RS18005	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CD196_RS18010	COG0037	tRNA processing
CD196_RS18020	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CD196_RS18035	COG1802	Transcriptional regulator
CD196_RS18040	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CD196_RS18070	COG0653	protein targeting
CD196_RS18095	COG2271	Major facilitator Superfamily
CD196_RS18100	COG0626	cystathionine gamma-synthase activity
CD196_RS18125	COG0564	pseudouridine synthase activity
CD196_RS18130	COG4978	Transcriptional regulator
CD196_RS18130	COG0789	Transcriptional regulator
CD196_RS18140	COG0577	efflux transmembrane transporter activity
CD196_RS18140	COG1136	(ABC) transporter
CD196_RS18145	COG5002	protein histidine kinase activity
CD196_RS18170	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CD196_RS18180	COG0284	orotidine-5'-phosphate decarboxylase activity
CD196_RS18200	COG0646	methionine synthase
CD196_RS18200	COG1410	methionine synthase
CD196_RS18210	COG1854	S-ribosylhomocysteine lyase activity
CD196_RS18225	COG1876	peptidase activity
CD196_RS18230	COG0037	tRNA processing
CD196_RS18235	COG1408	metallophosphoesterase
CD196_RS18250	COG1141	Ferredoxin
CD196_RS18255	COG3964	amidohydrolase
CD196_RS18265	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CD196_RS18275	COG0346	lactoylglutathione lyase activity
CD196_RS18280	COG0534	Mate efflux family protein
CD196_RS18330	COG1674	ftsk spoiiie
CD196_RS18335	COG2946	Replication initiation factor
CD196_RS18385	COG0741	lytic transglycosylase activity
CD196_RS18385	COG0791	NLP P60 protein
CD196_RS18450	COG0789	Transcriptional regulator
CD196_RS18450	COG4978	Transcriptional regulator
CD196_RS18465	COG5504	Zn-dependent protease
CD196_RS18475	COG0519	Catalyzes the synthesis of GMP from XMP
CD196_RS18485	COG1357	PFAM Pentapeptide repeats (8 copies)
CD196_RS18490	COG2824	Alkylphosphonate utilization operon protein PhnA
CD196_RS18505	COG0352	thiamine-phosphate diphosphorylase activity
CD196_RS18510	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CD196_RS18515	COG0517	IMP dehydrogenase activity
CD196_RS18515	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CD196_RS18560	COG0583	DNA-binding transcription factor activity
CD196_RS18565	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CD196_RS18565	COG1522	sequence-specific DNA binding
CD196_RS18580	COG3964	amidohydrolase
CD196_RS18590	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CD196_RS18595	COG2188	Transcriptional regulator
CD196_RS18600	COG1447	Phosphotransferase system cellobiose-specific component IIA
CD196_RS18605	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CD196_RS18610	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CD196_RS18615	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CD196_RS18620	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CD196_RS18635	COG1484	DNA-dependent DNA replication
CD196_RS18660	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CD196_RS18670	COG0305	Participates in initiation and elongation during chromosome replication
CD196_RS18675	COG0359	binds to the 23S rRNA
CD196_RS18680	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
CD196_RS18695	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CD196_RS18700	COG0629	single-stranded DNA binding
CD196_RS18705	COG0360	Binds together with S18 to 16S ribosomal RNA
CD196_RS18710	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CD196_RS18725	COG0425	Belongs to the sulfur carrier protein TusA family
CD196_RS18740	COG1104	cysteine desulfurase activity
CD196_RS18745	COG1475	DNA binding
CD196_RS18750	COG1192	Involved in chromosome partitioning
CD196_RS18755	COG1475	DNA binding
CD196_RS18760	COG0357	Ribosomal RNA small subunit methyltransferase G
CD196_RS18765	COG0445	tRNA wobble uridine modification
CD196_RS18770	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CD196_RS18775	COG1847	R3H domain protein
CD196_RS18780	COG0706	membrane insertase activity
CD196_RS18785	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CD196_RS18790	COG0594	ribonuclease P activity
CD196_RS18795	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CD196_RS18820	COG1376	ErfK ybiS ycfS ynhG family protein