locus-tag	class	description
TW87_RS00005	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
TW87_RS00035	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TW87_RS00040	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TW87_RS00050	COG2171	N-acyltransferase activity
TW87_RS00060	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
TW87_RS00070	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
TW87_RS00075	COG3681	Belongs to the UPF0597 family
TW87_RS00080	COG3829	transcription factor binding
TW87_RS00085	COG2226	methyltransferase
TW87_RS00110	COG0252	asparaginase activity
TW87_RS00110	COG5275	peptidyl-tyrosine sulfation
TW87_RS00115	COG5275	peptidyl-tyrosine sulfation
TW87_RS00115	COG0252	asparaginase activity
TW87_RS00120	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
TW87_RS00125	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
TW87_RS00135	COG5275	peptidyl-tyrosine sulfation
TW87_RS00135	COG0252	asparaginase activity
TW87_RS00150	COG4656	Part of a membrane complex involved in electron transport
TW87_RS00160	COG0726	polysaccharide deacetylase
TW87_RS00185	COG0285	dihydrofolate synthase activity
TW87_RS00195	COG3279	Response regulator of the LytR AlgR family
TW87_RS00200	COG0525	valine-tRNA ligase activity
TW87_RS00205	COG0726	polysaccharide deacetylase
TW87_RS00220	COG0704	Plays a role in the regulation of phosphate uptake
TW87_RS00225	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TW87_RS00230	COG0581	inorganic phosphate transmembrane transporter activity
TW87_RS00235	COG0573	inorganic phosphate transmembrane transporter activity
TW87_RS00255	COG0745	RESPONSE REGULATOR receiver
TW87_RS00260	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
TW87_RS00265	COG1164	Oligoendopeptidase f
TW87_RS00270	COG1285	pathogenesis
TW87_RS00290	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
TW87_RS00295	COG3716	PTS system mannose fructose sorbose family IID component
TW87_RS00300	COG3715	PTS system
TW87_RS00305	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
TW87_RS00305	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TW87_RS00310	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
TW87_RS00310	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TW87_RS00320	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TW87_RS00335	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TW87_RS00340	COG0166	Belongs to the GPI family
TW87_RS00350	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
TW87_RS00365	COG1405	negative regulation of cell septum assembly
TW87_RS00365	COG3012	SEC-C Motif Domain Protein
TW87_RS00390	COG1459	type II secretion system
TW87_RS00395	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TW87_RS00410	COG2814	Major facilitator Superfamily
TW87_RS00415	COG0218	Necessary for normal cell division and for the maintenance of normal septation
TW87_RS00420	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TW87_RS00430	COG2059	Chromate
TW87_RS00435	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TW87_RS00440	COG0740	serine-type endopeptidase activity
TW87_RS00445	COG0544	peptidyl-prolyl cis-trans isomerase activity
TW87_RS00460	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TW87_RS00480	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
TW87_RS00480	COG0493	'glutamate synthase
TW87_RS00490	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
TW87_RS00500	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
TW87_RS00505	COG3383	formate dehydrogenase (NAD+) activity
TW87_RS00510	COG3383	formate dehydrogenase (NAD+) activity
TW87_RS00560	COG0463	Glycosyl transferase, family 2
TW87_RS00560	COG0457	Tetratricopeptide repeat
TW87_RS00575	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TW87_RS00585	COG0778	Nitroreductase
TW87_RS00590	COG1733	regulation of RNA biosynthetic process
TW87_RS00595	COG0693	protein deglycase activity
TW87_RS00600	COG1522	sequence-specific DNA binding
TW87_RS00610	COG0488	(ABC) transporter
TW87_RS00615	COG0745	RESPONSE REGULATOR receiver
TW87_RS00635	COG4555	ABC transporter
TW87_RS00640	COG5001	Diguanylate cyclase
TW87_RS00675	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
TW87_RS00705	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
TW87_RS00725	COG0745	RESPONSE REGULATOR receiver
TW87_RS00730	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
TW87_RS00750	COG0741	lytic transglycosylase activity
TW87_RS00750	COG0791	NLP P60 protein
TW87_RS00800	COG2946	Replication initiation factor
TW87_RS00805	COG1674	ftsk spoiiie
TW87_RS00840	COG0205	6-phosphofructokinase activity
TW87_RS00850	COG1481	regulation of sporulation
TW87_RS00865	COG1660	Displays ATPase and GTPase activities
TW87_RS00875	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TW87_RS00880	COG2116	formate transmembrane transporter activity
TW87_RS00885	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TW87_RS00915	COG0322	excinuclease ABC activity
TW87_RS00925	COG0556	nucleotide-excision repair
TW87_RS00935	COG1653	transport
TW87_RS00945	COG1175	transmembrane transport
TW87_RS00950	COG3842	ATPase activity
TW87_RS00970	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TW87_RS00970	COG1648	precorrin-2 dehydrogenase activity
TW87_RS00975	COG0113	porphobilinogen synthase activity
TW87_RS00985	COG0181	hydroxymethylbilane synthase activity
TW87_RS00995	COG2099	Precorrin-6x reductase
TW87_RS01025	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
TW87_RS01040	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TW87_RS01050	COG1797	cobyrinic acid a,c-diamide synthase activity
TW87_RS01055	COG1492	cobalamin metabolic process
TW87_RS01060	COG0406	alpha-ribazole phosphatase activity
TW87_RS01065	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
TW87_RS01070	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
TW87_RS01075	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
TW87_RS01095	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
TW87_RS01110	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
TW87_RS01115	COG1447	Phosphotransferase system cellobiose-specific component IIA
TW87_RS01120	COG1363	Peptidase, m42
TW87_RS01125	COG3711	transcriptional antiterminator
TW87_RS01130	COG0191	fructose-bisphosphate aldolase activity
TW87_RS01135	COG2222	sugar isomerase
TW87_RS01150	COG2188	Transcriptional regulator
TW87_RS01175	COG0793	Belongs to the peptidase S41A family
TW87_RS01175	COG3409	Peptidoglycan-binding domain 1 protein
TW87_RS01180	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
TW87_RS01190	COG3949	Membrane
TW87_RS01195	COG3958	Transketolase
TW87_RS01200	COG3959	Transketolase, thiamine diphosphate binding domain
TW87_RS01205	COG2337	Toxic component of a toxin-antitoxin (TA) module
TW87_RS01225	COG0516	GMP reductase activity
TW87_RS01225	COG0517	IMP dehydrogenase activity
TW87_RS01230	COG0736	holo-[acyl-carrier-protein] synthase activity
TW87_RS01235	COG0355	proton-transporting ATP synthase activity, rotational mechanism
TW87_RS01240	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
TW87_RS01245	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
TW87_RS01250	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
TW87_RS01255	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TW87_RS01260	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TW87_RS01265	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TW87_RS01290	COG3608	succinylglutamate desuccinylase aspartoacylase
TW87_RS01290	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
TW87_RS01295	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
TW87_RS01300	COG0698	ribose 5-phosphate isomerase
TW87_RS01310	COG0009	L-threonylcarbamoyladenylate synthase
TW87_RS01320	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TW87_RS01325	COG2890	protein-(glutamine-N5) methyltransferase activity
TW87_RS01330	COG3872	metal-dependent enzyme
TW87_RS01335	COG0254	rRNA binding
TW87_RS01340	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TW87_RS01345	COG1210	Utp--glucose-1-phosphate uridylyltransferase
TW87_RS01355	COG2208	phosphoserine phosphatase activity
TW87_RS01360	COG0248	Ppx GppA phosphatase
TW87_RS01380	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
TW87_RS01390	COG3956	TIGRFAM MazG family protein
TW87_RS01395	COG2244	polysaccharide biosynthetic process
TW87_RS01400	COG2002	toxin-antitoxin pair type II binding
TW87_RS01405	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TW87_RS01410	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
TW87_RS01415	COG0193	aminoacyl-tRNA hydrolase activity
TW87_RS01465	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TW87_RS01480	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TW87_RS01485	COG2088	sporulation resulting in formation of a cellular spore
TW87_RS01490	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
TW87_RS01495	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TW87_RS01505	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
TW87_RS01510	COG2195	Cleaves the N-terminal amino acid of tripeptides
TW87_RS01520	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TW87_RS01525	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
TW87_RS01530	COG1840	ABC-type Fe3 transport system, periplasmic component
TW87_RS01540	COG3842	ATPase activity
TW87_RS01545	COG1840	ABC-type Fe3 transport system, periplasmic component
TW87_RS01555	COG3842	ATPase activity
TW87_RS01560	COG0613	PHP domain protein
TW87_RS01565	COG3454	Phosphonate metabolism
TW87_RS01570	COG4778	phosphonate C-P lyase system protein PhnL
TW87_RS01575	COG4107	phosphonate C-P lyase system protein PhnK
TW87_RS01580	COG3627	carbon phosphorus lyase activity
TW87_RS01600	COG0084	hydrolase, TatD family'
TW87_RS01605	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TW87_RS01605	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TW87_RS01610	COG0700	Nucleoside recognition
TW87_RS01620	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
TW87_RS01625	COG1522	sequence-specific DNA binding
TW87_RS01630	COG0617	tRNA 3'-terminal CCA addition
TW87_RS01635	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
TW87_RS01640	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
TW87_RS01645	COG1774	PSP1 C-terminal conserved region
TW87_RS01650	COG0470	DNA polymerase III
TW87_RS01655	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TW87_RS01660	COG1982	Orn Lys Arg decarboxylase major
TW87_RS01665	COG2155	Conserved Protein
TW87_RS01690	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
TW87_RS01695	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TW87_RS01705	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
TW87_RS01715	COG3191	aminopeptidase activity
TW87_RS01725	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TW87_RS01730	COG0037	tRNA processing
TW87_RS01740	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
TW87_RS01755	COG1802	Transcriptional regulator
TW87_RS01760	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TW87_RS01790	COG0653	protein targeting
TW87_RS01815	COG2271	Major facilitator Superfamily
TW87_RS01820	COG0626	cystathionine gamma-synthase activity
TW87_RS01845	COG0564	pseudouridine synthase activity
TW87_RS01850	COG0789	Transcriptional regulator
TW87_RS01850	COG4978	Transcriptional regulator
TW87_RS01860	COG1136	(ABC) transporter
TW87_RS01860	COG0577	efflux transmembrane transporter activity
TW87_RS01865	COG5002	protein histidine kinase activity
TW87_RS01890	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TW87_RS01900	COG0284	orotidine-5'-phosphate decarboxylase activity
TW87_RS01920	COG0646	methionine synthase
TW87_RS01920	COG1410	methionine synthase
TW87_RS01930	COG1854	S-ribosylhomocysteine lyase activity
TW87_RS01945	COG1876	peptidase activity
TW87_RS01950	COG0037	tRNA processing
TW87_RS01955	COG1408	metallophosphoesterase
TW87_RS01970	COG1141	Ferredoxin
TW87_RS01975	COG3964	amidohydrolase
TW87_RS01985	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
TW87_RS01995	COG0346	lactoylglutathione lyase activity
TW87_RS02000	COG0534	Mate efflux family protein
TW87_RS02015	COG0789	Transcriptional regulator
TW87_RS02015	COG4978	Transcriptional regulator
TW87_RS02025	COG5504	Zn-dependent protease
TW87_RS02035	COG0519	Catalyzes the synthesis of GMP from XMP
TW87_RS02045	COG1357	PFAM Pentapeptide repeats (8 copies)
TW87_RS02050	COG2824	Alkylphosphonate utilization operon protein PhnA
TW87_RS02055	COG1136	(ABC) transporter
TW87_RS02055	COG0577	efflux transmembrane transporter activity
TW87_RS02065	COG5002	protein histidine kinase activity
TW87_RS02065	COG5001	Diguanylate cyclase
TW87_RS02065	COG3447	MASE1 domain protein
TW87_RS02070	COG0352	thiamine-phosphate diphosphorylase activity
TW87_RS02075	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TW87_RS02080	COG0517	IMP dehydrogenase activity
TW87_RS02080	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
TW87_RS02100	COG1335	isochorismatase
TW87_RS02110	COG0789	Transcriptional regulator
TW87_RS02140	COG0583	DNA-binding transcription factor activity
TW87_RS02145	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TW87_RS02145	COG1522	sequence-specific DNA binding
TW87_RS02160	COG3964	amidohydrolase
TW87_RS02170	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
TW87_RS02175	COG2188	Transcriptional regulator
TW87_RS02180	COG1447	Phosphotransferase system cellobiose-specific component IIA
TW87_RS02185	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
TW87_RS02190	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
TW87_RS02195	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
TW87_RS02200	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
TW87_RS02215	COG1484	DNA-dependent DNA replication
TW87_RS02240	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TW87_RS02250	COG0305	Participates in initiation and elongation during chromosome replication
TW87_RS02255	COG0359	binds to the 23S rRNA
TW87_RS02260	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
TW87_RS02275	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TW87_RS02280	COG0629	single-stranded DNA binding
TW87_RS02285	COG0360	Binds together with S18 to 16S ribosomal RNA
TW87_RS02290	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TW87_RS02305	COG0425	Belongs to the sulfur carrier protein TusA family
TW87_RS02320	COG1104	cysteine desulfurase activity
TW87_RS02325	COG1475	DNA binding
TW87_RS02330	COG1192	Involved in chromosome partitioning
TW87_RS02335	COG1475	DNA binding
TW87_RS02340	COG0357	Ribosomal RNA small subunit methyltransferase G
TW87_RS02345	COG0445	tRNA wobble uridine modification
TW87_RS02350	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TW87_RS02355	COG1847	R3H domain protein
TW87_RS02360	COG0706	membrane insertase activity
TW87_RS02365	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TW87_RS02370	COG0594	ribonuclease P activity
TW87_RS02375	COG0230	Belongs to the bacterial ribosomal protein bL34 family
TW87_RS02380	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TW87_RS02385	COG0592	DNA-directed DNA polymerase activity
TW87_RS02395	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TW87_RS02400	COG0187	DNA topoisomerase II activity
TW87_RS02405	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TW87_RS02420	COG1366	Belongs to the anti-sigma-factor antagonist family
TW87_RS02430	COG1191	sigma factor activity
TW87_RS02480	COG1827	regulation of RNA biosynthetic process
TW87_RS02485	COG0668	transmembrane transport
TW87_RS02490	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TW87_RS02495	COG0590	tRNA wobble adenosine to inosine editing
TW87_RS02510	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TW87_RS02515	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TW87_RS02520	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TW87_RS02530	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TW87_RS02770	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
TW87_RS02775	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TW87_RS02780	COG4463	regulation of RNA biosynthetic process
TW87_RS02785	COG3880	PFAM UvrB UvrC protein
TW87_RS02790	COG3869	Catalyzes the specific phosphorylation of arginine residues in
TW87_RS02795	COG0542	response to heat
TW87_RS02800	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
TW87_RS02805	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
TW87_RS02810	COG4956	integral membrane protein (PIN domain superfamily)
TW87_RS02830	COG3507	Belongs to the glycosyl hydrolase 43 family
TW87_RS02840	COG2390	Transcriptional regulator
TW87_RS02845	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TW87_RS02850	COG0022	dehydrogenase e1 component
TW87_RS02855	COG0508	dehydrogenase complex catalyzes the overall conversion of
TW87_RS02860	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TW87_RS02865	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
TW87_RS02865	COG3933	PFAM sigma-54 factor interaction domain-containing protein
TW87_RS02875	COG3414	Phosphotransferase system galactitol-specific IIB component
TW87_RS02880	COG3775	system Galactitol-specific IIC component
TW87_RS02895	COG0095	Lipoate-protein ligase
TW87_RS02900	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TW87_RS02905	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TW87_RS02910	COG0442	prolyl-tRNA aminoacylation
TW87_RS02915	COG0442	prolyl-tRNA aminoacylation
TW87_RS02920	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TW87_RS02930	COG0215	cysteine-tRNA ligase activity
TW87_RS02945	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TW87_RS02950	COG3688	RNA-binding protein containing a PIN domain
TW87_RS02960	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TW87_RS02965	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TW87_RS02975	COG0250	Participates in transcription elongation, termination and antitermination
TW87_RS02980	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TW87_RS02985	COG0081	regulation of translation
TW87_RS02990	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TW87_RS02995	COG0222	ribosome binding
TW87_RS03005	COG0085	RNA polymerase activity
TW87_RS03010	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TW87_RS03015	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
TW87_RS03020	COG0049	tRNA binding
TW87_RS03025	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TW87_RS03030	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TW87_RS03035	COG0051	transcription antitermination factor activity, RNA binding
TW87_RS03040	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TW87_RS03045	COG0088	Forms part of the polypeptide exit tunnel
TW87_RS03050	COG0089	rRNA binding
TW87_RS03055	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TW87_RS03060	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TW87_RS03065	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
TW87_RS03070	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TW87_RS03075	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TW87_RS03080	COG0255	Belongs to the universal ribosomal protein uL29 family
TW87_RS03085	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TW87_RS03090	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TW87_RS03095	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TW87_RS03100	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TW87_RS03105	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TW87_RS03110	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TW87_RS03115	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TW87_RS03120	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
TW87_RS03125	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TW87_RS03130	COG1841	ribosomal large subunit assembly
TW87_RS03135	COG0200	Binds to the 23S rRNA
TW87_RS03145	COG0563	adenylate kinase activity
TW87_RS03150	COG0024	Methionine aminopeptidase
TW87_RS03160	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TW87_RS03165	COG0257	Belongs to the bacterial ribosomal protein bL36 family
TW87_RS03170	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TW87_RS03175	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TW87_RS03180	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TW87_RS03185	COG0202	RNA polymerase activity
TW87_RS03190	COG0203	ribosomal protein L17
TW87_RS03195	COG1122	ATPase activity
TW87_RS03200	COG1122	ATPase activity
TW87_RS03205	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
TW87_RS03210	COG0101	tRNA pseudouridine synthase activity
TW87_RS03215	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TW87_RS03220	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TW87_RS03225	COG0860	N-Acetylmuramoyl-L-alanine amidase
TW87_RS03470	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
TW87_RS03485	COG0280	phosphate acetyltransferase
TW87_RS03520	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TW87_RS03525	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TW87_RS03530	COG2897	thiosulfate sulfurtransferase activity
TW87_RS03540	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TW87_RS03545	COG2385	sporulation resulting in formation of a cellular spore
TW87_RS03555	COG1609	Transcriptional regulator
TW87_RS03560	COG1077	Cell shape determining protein MreB Mrl
TW87_RS03565	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TW87_RS03575	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TW87_RS03580	COG3949	Membrane
TW87_RS03585	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
TW87_RS03590	COG1040	competence protein
TW87_RS03595	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TW87_RS03595	COG3711	transcriptional antiterminator
TW87_RS03600	COG1447	Phosphotransferase system cellobiose-specific component IIA
TW87_RS03605	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
TW87_RS03610	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
TW87_RS03620	COG1446	asparaginase
TW87_RS03625	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TW87_RS03630	COG3142	Participates in the control of copper homeostasis
TW87_RS03635	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
TW87_RS03640	COG0653	protein targeting
TW87_RS03645	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TW87_RS03650	COG2183	response to ionizing radiation
TW87_RS03655	COG1228	amidohydrolase
TW87_RS03670	COG0802	atpase or kinase
TW87_RS03675	COG1214	PFAM Peptidase M22, glycoprotease
TW87_RS03680	COG0456	acetyltransferase
TW87_RS03685	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TW87_RS03700	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
TW87_RS03720	COG3279	Response regulator of the LytR AlgR family
TW87_RS03760	COG1473	amidohydrolase
TW87_RS03775	COG0534	Mate efflux family protein
TW87_RS03780	COG0488	(ABC) transporter
TW87_RS03785	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
TW87_RS03795	COG2221	Nitrite and sulphite reductase 4Fe-4S
TW87_RS03805	COG1151	hydroxylamine reductase activity
TW87_RS03820	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
TW87_RS03855	COG0540	Belongs to the ATCase OTCase family
TW87_RS03860	COG0543	2 iron, 2 sulfur cluster binding
TW87_RS03865	COG0167	dihydroorotate dehydrogenase activity
TW87_RS03870	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TW87_RS03880	COG0583	DNA-binding transcription factor activity
TW87_RS03895	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TW87_RS03900	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TW87_RS03905	COG0459	protein refolding
TW87_RS03910	COG1691	(AIR) carboxylase
TW87_RS03915	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
TW87_RS03920	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
TW87_RS03925	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TW87_RS03925	COG0519	Catalyzes the synthesis of GMP from XMP
TW87_RS03950	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TW87_RS03955	COG2200	EAL domain
TW87_RS03955	COG2771	luxR family
TW87_RS03970	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TW87_RS03975	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TW87_RS03985	COG1011	Hydrolase
TW87_RS04010	COG0778	Nitroreductase
TW87_RS04015	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
TW87_RS04020	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TW87_RS04025	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
TW87_RS04030	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TW87_RS04035	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TW87_RS04040	COG0138	bifunctional purine biosynthesis protein purh
TW87_RS04045	COG0151	Belongs to the GarS family
TW87_RS04050	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TW87_RS04060	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
TW87_RS04075	COG0741	lytic transglycosylase activity
TW87_RS04110	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
TW87_RS04115	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
TW87_RS04130	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
TW87_RS04140	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
TW87_RS04150	COG0463	Glycosyl transferase, family 2
TW87_RS04185	COG4786	Flagellar basal body rod
TW87_RS04195	COG1677	Flagellar hook-basal body complex protein FliE
TW87_RS04200	COG1766	The M ring may be actively involved in energy transduction
TW87_RS04205	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TW87_RS04215	COG1157	protein secretion by the type III secretion system
TW87_RS04230	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
TW87_RS04235	COG4786	Flagellar basal body rod
TW87_RS04245	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
TW87_RS04250	COG1360	Flagellar Motor Protein
TW87_RS04265	COG1338	Plays a role in the flagellum-specific transport system
TW87_RS04275	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TW87_RS04280	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TW87_RS04285	COG1419	protein localization to endoplasmic reticulum
TW87_RS04295	COG1191	sigma factor activity
TW87_RS04310	COG4786	Flagellar basal body rod
TW87_RS04325	COG1776	CheC inhibitor of MCP methylation
TW87_RS04325	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TW87_RS04340	COG1454	alcohol dehydrogenase
TW87_RS04345	COG1533	DNA photolyase activity
TW87_RS04360	COG1733	regulation of RNA biosynthetic process
TW87_RS04380	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TW87_RS04385	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
TW87_RS04385	COG3933	PFAM sigma-54 factor interaction domain-containing protein
TW87_RS04390	COG3933	PFAM sigma-54 factor interaction domain-containing protein
TW87_RS04390	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
TW87_RS04415	COG3716	PTS system mannose fructose sorbose family IID component
TW87_RS04425	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TW87_RS04430	COG3620	sequence-specific DNA binding
TW87_RS04440	COG1131	(ABC) transporter
TW87_RS04460	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TW87_RS04465	COG1609	Transcriptional regulator
TW87_RS04470	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TW87_RS04475	COG1879	ABC-type sugar transport system periplasmic component
TW87_RS04480	COG1129	ABC transporter
TW87_RS04485	COG1172	Belongs to the binding-protein-dependent transport system permease family
TW87_RS04490	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TW87_RS04500	COG1473	amidohydrolase
TW87_RS04540	COG2217	Heavy metal translocating P-type atpase
TW87_RS04560	COG0586	Pfam SNARE associated Golgi protein
TW87_RS04590	COG2205	protein histidine kinase activity
TW87_RS04595	COG0745	RESPONSE REGULATOR receiver
TW87_RS04630	COG1122	ATPase activity
TW87_RS04635	COG0210	DNA helicase
TW87_RS04640	COG1362	aminopeptidase activity
TW87_RS04650	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
TW87_RS04665	COG1454	alcohol dehydrogenase
TW87_RS04665	COG1012	belongs to the aldehyde dehydrogenase family
TW87_RS04675	COG1136	(ABC) transporter
TW87_RS04685	COG3290	protein histidine kinase activity
TW87_RS04715	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TW87_RS04720	COG2357	RelA SpoT domain protein
TW87_RS04740	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
TW87_RS04765	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TW87_RS04765	COG2190	(PTS) system
TW87_RS04765	COG1263	PTS System
TW87_RS04770	COG2723	6-phospho-beta-galactosidase activity
TW87_RS04775	COG3711	transcriptional antiterminator
TW87_RS04785	COG0367	asparagine synthase
TW87_RS04800	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TW87_RS04825	COG1960	acyl-CoA dehydrogenase activity
TW87_RS04830	COG2086	electron transfer activity
TW87_RS04835	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
TW87_RS04840	COG3829	transcription factor binding
TW87_RS04845	COG0191	fructose-bisphosphate aldolase activity
TW87_RS04855	COG1187	pseudouridine synthase activity
TW87_RS04890	COG3829	transcription factor binding
TW87_RS04895	COG3804	dihydrodipicolinate reductase
TW87_RS04905	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TW87_RS04915	COG5012	cobalamin binding
TW87_RS04925	COG3457	Alanine racemase
TW87_RS04930	COG1757	Na H antiporter
TW87_RS04950	COG3973	AAA domain
TW87_RS04960	COG1136	(ABC) transporter
TW87_RS04970	COG5002	protein histidine kinase activity
TW87_RS04975	COG0745	RESPONSE REGULATOR receiver
TW87_RS04980	COG1309	transcriptional regulator
TW87_RS04990	COG1737	Transcriptional regulator
TW87_RS05000	COG0561	phosphatase activity
TW87_RS05005	COG0366	Alpha amylase catalytic
TW87_RS05010	COG1263	PTS System
TW87_RS05010	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TW87_RS05010	COG2190	(PTS) system
TW87_RS05025	COG0655	NAD(P)H dehydrogenase (quinone) activity
TW87_RS05055	COG1131	(ABC) transporter
TW87_RS05075	COG5002	protein histidine kinase activity
TW87_RS05085	COG1136	(ABC) transporter
TW87_RS05100	COG0745	RESPONSE REGULATOR receiver
TW87_RS05105	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TW87_RS05120	COG1063	alcohol dehydrogenase
TW87_RS05130	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TW87_RS05140	COG3716	PTS system mannose fructose sorbose family IID component
TW87_RS05160	COG1686	Belongs to the peptidase S11 family
TW87_RS05165	COG3933	PFAM sigma-54 factor interaction domain-containing protein
TW87_RS05165	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
TW87_RS05185	COG2205	protein histidine kinase activity
TW87_RS05210	COG2195	Cleaves the N-terminal amino acid of tripeptides
TW87_RS05215	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
TW87_RS05240	COG2378	regulation of single-species biofilm formation
TW87_RS05250	COG2201	protein-glutamate methylesterase activity
TW87_RS05255	COG1776	CheC inhibitor of MCP methylation
TW87_RS05260	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
TW87_RS05265	COG0835	chemotaxis
TW87_RS05275	COG0840	transmembrane signaling receptor activity
TW87_RS05280	COG2198	Histidine kinase
TW87_RS05280	COG0643	Histidine kinase
TW87_RS05285	COG0835	chemotaxis
TW87_RS05295	COG2201	protein-glutamate methylesterase activity
TW87_RS05345	COG2339	peptidase activity
TW87_RS05350	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
TW87_RS05350	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TW87_RS05355	COG0681	Belongs to the peptidase S26 family
TW87_RS05370	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TW87_RS05375	COG2066	Belongs to the glutaminase family
TW87_RS05385	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
TW87_RS05400	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
TW87_RS05405	COG1067	ATP-dependent peptidase activity
TW87_RS05410	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TW87_RS05415	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
TW87_RS05425	COG1744	ABC transporter substrate-binding protein PnrA-like
TW87_RS05450	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TW87_RS05490	COG1309	transcriptional regulator
TW87_RS05495	COG3848	Pyruvate phosphate dikinase
TW87_RS05495	COG0574	Belongs to the PEP-utilizing enzyme family
TW87_RS05505	COG3706	GGDEF domain
TW87_RS05565	COG3969	phosphoadenosine phosphosulfate
TW87_RS05570	COG1475	DNA binding
TW87_RS05585	COG3546	catalase activity
TW87_RS05595	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
TW87_RS05620	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
TW87_RS05650	COG3279	Response regulator of the LytR AlgR family
TW87_RS05655	COG0577	efflux transmembrane transporter activity
TW87_RS05660	COG1136	(ABC) transporter
TW87_RS05675	COG0789	Transcriptional regulator
TW87_RS05675	COG4978	Transcriptional regulator
TW87_RS05720	COG0305	Participates in initiation and elongation during chromosome replication
TW87_RS05740	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TW87_RS05745	COG0534	Mate efflux family protein
TW87_RS05760	COG4335	DNA alkylation repair
TW87_RS05815	COG0745	RESPONSE REGULATOR receiver
TW87_RS05820	COG2205	protein histidine kinase activity
TW87_RS05825	COG1131	(ABC) transporter
TW87_RS05835	COG3177	Filamentation induced by cAMP protein fic
TW87_RS05840	COG1802	Transcriptional regulator
TW87_RS05845	COG1506	peptidase
TW87_RS05845	COG0823	Involved in the tonB-independent uptake of proteins
TW87_RS05845	COG4946	Tricorn protease homolog
TW87_RS05850	COG0823	Involved in the tonB-independent uptake of proteins
TW87_RS05850	COG1506	peptidase
TW87_RS05850	COG4946	Tricorn protease homolog
TW87_RS05870	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TW87_RS05890	COG0038	chloride channel
TW87_RS05965	COG2205	protein histidine kinase activity
TW87_RS06005	COG1595	DNA-templated transcription, initiation
TW87_RS06020	COG2814	Major facilitator Superfamily
TW87_RS06025	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TW87_RS06030	COG1609	Transcriptional regulator
TW87_RS06040	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TW87_RS06045	COG0291	Belongs to the bacterial ribosomal protein bL35 family
TW87_RS06050	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TW87_RS06080	COG0789	Transcriptional regulator
TW87_RS06100	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TW87_RS06105	COG0569	domain protein
TW87_RS06110	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TW87_RS06115	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
TW87_RS06120	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TW87_RS06120	COG0072	phenylalanine-tRNA ligase activity
TW87_RS06135	COG0826	peptidase U32
TW87_RS06145	COG1051	belongs to the nudix hydrolase family
TW87_RS06155	COG3706	GGDEF domain
TW87_RS06160	COG2195	Cleaves the N-terminal amino acid of tripeptides
TW87_RS06165	COG1193	negative regulation of DNA recombination
TW87_RS06170	COG1683	Conserved Protein
TW87_RS06175	COG0018	arginyl-trna synthetase
TW87_RS06190	COG1032	radical SAM domain protein
TW87_RS06200	COG0583	DNA-binding transcription factor activity
TW87_RS06205	COG0110	maltose O-acetyltransferase activity
TW87_RS06210	COG0280	phosphate acetyltransferase
TW87_RS06215	COG1151	hydroxylamine reductase activity
TW87_RS06225	COG2759	Belongs to the formate--tetrahydrofolate ligase family
TW87_RS06230	COG3404	Formiminotransferase-cyclodeaminase
TW87_RS06235	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TW87_RS06245	COG0646	methionine synthase
TW87_RS06245	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
TW87_RS06250	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TW87_RS06280	COG0509	glycine decarboxylation via glycine cleavage system
TW87_RS06300	COG0095	Lipoate-protein ligase
TW87_RS06320	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TW87_RS06335	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TW87_RS06335	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
TW87_RS06345	COG3192	ethanolamine utilization protein
TW87_RS06350	COG1349	DNA-binding transcription factor activity
TW87_RS06360	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
TW87_RS06365	COG1360	Flagellar Motor Protein
TW87_RS06385	COG0210	DNA helicase
TW87_RS06390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TW87_RS06395	COG0765	amino acid transport
TW87_RS06400	COG1126	abc transporter atp-binding protein
TW87_RS06410	COG0301	tRNA thio-modification
TW87_RS06420	COG0778	Nitroreductase
TW87_RS06425	COG3300	MHYT domain
TW87_RS06425	COG5001	Diguanylate cyclase
TW87_RS06430	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
TW87_RS06440	COG0530	calcium, potassium:sodium antiporter activity
TW87_RS06445	COG0513	Belongs to the DEAD box helicase family
TW87_RS06475	COG1028	Short-chain dehydrogenase reductase Sdr
TW87_RS06480	COG0243	molybdopterin cofactor binding
TW87_RS06485	COG1366	Belongs to the anti-sigma-factor antagonist family
TW87_RS06490	COG2172	sigma factor antagonist activity
TW87_RS06495	COG1191	sigma factor activity
TW87_RS06505	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TW87_RS06530	COG1473	amidohydrolase
TW87_RS06540	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TW87_RS06550	COG0750	zinc metalloprotease
TW87_RS06555	COG0860	N-Acetylmuramoyl-L-alanine amidase
TW87_RS06560	COG0488	(ABC) transporter
TW87_RS06575	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TW87_RS06590	COG1739	Uncharacterized protein family UPF0029
TW87_RS06600	COG0730	response to heat
TW87_RS06605	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TW87_RS06610	COG0217	transcriptional regulatory protein
TW87_RS06615	COG1609	Transcriptional regulator
TW87_RS06620	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TW87_RS06635	COG1024	Enoyl-CoA hydratase
TW87_RS06640	COG2610	gluconate transmembrane transporter activity
TW87_RS06655	COG2086	electron transfer activity
TW87_RS06660	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
TW87_RS06705	COG2186	Transcriptional regulator
TW87_RS06710	COG2814	Major facilitator Superfamily
TW87_RS06715	COG1263	PTS System
TW87_RS06715	COG2190	(PTS) system
TW87_RS06715	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TW87_RS06720	COG2723	6-phospho-beta-galactosidase activity
TW87_RS06730	COG0745	RESPONSE REGULATOR receiver
TW87_RS06735	COG2205	protein histidine kinase activity
TW87_RS06755	COG1592	Rubrerythrin
TW87_RS06765	COG2033	superoxide reductase activity
TW87_RS06770	COG0069	glutamate synthase activity
TW87_RS06790	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TW87_RS06800	COG0473	3-isopropylmalate dehydrogenase activity
TW87_RS06805	COG1846	Transcriptional regulator
TW87_RS06830	COG0179	Fumarylacetoacetate (FAA) hydrolase
TW87_RS06835	COG0138	bifunctional purine biosynthesis protein purh
TW87_RS06845	COG0297	glycogen (starch) synthase activity
TW87_RS06845	COG0438	transferase activity, transferring glycosyl groups
TW87_RS06875	COG1473	amidohydrolase
TW87_RS06880	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
TW87_RS06895	COG0601	transmembrane transport
TW87_RS06900	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TW87_RS06910	COG0444	Belongs to the ABC transporter superfamily
TW87_RS06915	COG4608	Belongs to the ABC transporter superfamily
TW87_RS06920	COG3933	PFAM sigma-54 factor interaction domain-containing protein
TW87_RS06920	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
TW87_RS06935	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
TW87_RS06945	COG1486	melibiose metabolic process
TW87_RS06955	COG1073	alpha beta
TW87_RS06965	COG1910	domain protein
TW87_RS06970	COG0725	ABC transporter, periplasmic molybdate-binding protein
TW87_RS06975	COG4149	molybdate abc transporter
TW87_RS06980	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
TW87_RS06985	COG0110	maltose O-acetyltransferase activity
TW87_RS06995	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
TW87_RS07000	COG4120	Belongs to the binding-protein-dependent transport system permease family
TW87_RS07005	COG2984	ABC transporter substrate binding protein
TW87_RS07015	COG4120	Belongs to the binding-protein-dependent transport system permease family
TW87_RS07035	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
TW87_RS07040	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
TW87_RS07045	COG0297	glycogen (starch) synthase activity
TW87_RS07050	COG0058	SHG alpha-glucan phosphorylase activity
TW87_RS07060	COG1802	Transcriptional regulator
TW87_RS07065	COG1982	Orn Lys Arg decarboxylase major
TW87_RS07070	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TW87_RS07075	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TW87_RS07080	COG0010	Belongs to the arginase family
TW87_RS07115	COG4868	Belongs to the UPF0371 family
TW87_RS07120	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
TW87_RS07130	COG1174	glycine betaine transport
TW87_RS07135	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
TW87_RS07165	COG0534	Mate efflux family protein
TW87_RS07170	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TW87_RS07170	COG0539	negative regulation of cytoplasmic translation
TW87_RS07175	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TW87_RS07185	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TW87_RS07190	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TW87_RS07195	COG0066	3-isopropylmalate dehydratase activity
TW87_RS07200	COG0473	3-isopropylmalate dehydrogenase activity
TW87_RS07215	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TW87_RS07225	COG3447	MASE1 domain protein
TW87_RS07225	COG5001	Diguanylate cyclase
TW87_RS07225	COG5002	protein histidine kinase activity
TW87_RS07250	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
TW87_RS07255	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
TW87_RS07265	COG0281	malic enzyme
TW87_RS07290	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
TW87_RS07295	COG0363	glucosamine-6-phosphate deaminase activity
TW87_RS07310	COG5002	protein histidine kinase activity
TW87_RS07315	COG5001	Diguanylate cyclase
TW87_RS07320	COG0789	Transcriptional regulator
TW87_RS07320	COG4978	Transcriptional regulator
TW87_RS07330	COG1132	(ABC) transporter
TW87_RS07350	COG2364	Membrane
TW87_RS07360	COG3842	ATPase activity
TW87_RS07365	COG1176	ABC-type spermidine putrescine transport system, permease component I
TW87_RS07370	COG1177	transmembrane transport
TW87_RS07375	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
TW87_RS07385	COG5298	Protein conserved in bacteria
TW87_RS07390	COG1215	transferase activity, transferring glycosyl groups
TW87_RS07405	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
TW87_RS07435	COG0860	N-Acetylmuramoyl-L-alanine amidase
TW87_RS07440	COG2247	cell wall binding repeat
TW87_RS07440	COG0860	N-Acetylmuramoyl-L-alanine amidase
TW87_RS07450	COG0210	DNA helicase
TW87_RS07460	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
TW87_RS07465	COG1074	ATP-dependent DNA helicase activity
TW87_RS07470	COG0420	3'-5' exonuclease activity
TW87_RS07475	COG0419	ATPase involved in DNA repair
TW87_RS07480	COG4536	flavin adenine dinucleotide binding
TW87_RS07490	COG2195	Cleaves the N-terminal amino acid of tripeptides
TW87_RS07500	COG0622	Phosphoesterase
TW87_RS07505	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TW87_RS07510	COG1131	(ABC) transporter
TW87_RS07525	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
TW87_RS07530	COG1960	acyl-CoA dehydrogenase activity
TW87_RS07535	COG2086	electron transfer activity
TW87_RS07540	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
TW87_RS07555	COG0183	Belongs to the thiolase family
TW87_RS07560	COG0564	pseudouridine synthase activity
TW87_RS07570	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TW87_RS07625	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TW87_RS07630	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TW87_RS07635	COG4224	UPF0291 protein
TW87_RS07640	COG1362	aminopeptidase activity
TW87_RS07645	COG2188	Transcriptional regulator
TW87_RS07665	COG1396	sequence-specific DNA binding
TW87_RS07675	COG3646	Phage regulatory protein
TW87_RS07675	COG3645	SOS response
TW87_RS07685	COG3617	BRO family, N-terminal domain
TW87_RS07695	COG1476	TRANSCRIPTIONal
TW87_RS07755	COG0270	DNA (cytosine-5-)-methyltransferase activity
TW87_RS07790	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
TW87_RS07830	COG5484	DNA packaging
TW87_RS07840	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TW87_RS07930	COG3655	Transcriptional regulator
TW87_RS07960	COG4193	domain, Protein
TW87_RS07970	COG3628	GPW Gp25 family protein
TW87_RS07975	COG3299	homolog of phage Mu protein gp47
TW87_RS08025	COG1388	LysM domain
TW87_RS08025	COG0860	N-Acetylmuramoyl-L-alanine amidase
TW87_RS08070	COG2188	Transcriptional regulator
TW87_RS08090	COG3715	PTS system
TW87_RS08095	COG3716	PTS system mannose fructose sorbose family IID component
TW87_RS08100	COG0583	DNA-binding transcription factor activity
TW87_RS08120	COG3414	Phosphotransferase system galactitol-specific IIB component
TW87_RS08125	COG1132	(ABC) transporter
TW87_RS08135	COG1473	amidohydrolase
TW87_RS08150	COG3279	Response regulator of the LytR AlgR family
TW87_RS08165	COG1882	Formate acetyltransferase
TW87_RS08170	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
TW87_RS08175	COG1396	sequence-specific DNA binding
TW87_RS08200	COG3708	Transcriptional regulator
TW87_RS08200	COG2207	Transcriptional regulator
TW87_RS08220	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TW87_RS08220	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TW87_RS08225	COG0237	dephospho-CoA kinase activity
TW87_RS08250	COG0346	lactoylglutathione lyase activity
TW87_RS08255	COG0791	NLP P60 protein
TW87_RS08265	COG4656	Part of a membrane complex involved in electron transport
TW87_RS08270	COG4658	electron transport chain
TW87_RS08275	COG4659	FMN binding
TW87_RS08280	COG4660	Part of a membrane complex involved in electron transport
TW87_RS08285	COG4657	Part of a membrane complex involved in electron transport
TW87_RS08290	COG2878	Part of a membrane complex involved in electron transport
TW87_RS08290	COG1245	4Fe-4S binding domain
TW87_RS08295	COG0424	maF-like protein
TW87_RS08300	COG2003	Belongs to the UPF0758 family
TW87_RS08305	COG1077	Cell shape determining protein MreB Mrl
TW87_RS08325	COG0850	regulation of cytokinetic process
TW87_RS08330	COG2894	cell division
TW87_RS08335	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
TW87_RS08340	COG0772	Belongs to the SEDS family
TW87_RS08345	COG1803	Methylglyoxal synthase
TW87_RS08350	COG1695	Transcriptional regulator
TW87_RS08365	COG0426	domain, Protein
TW87_RS08385	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TW87_RS08395	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TW87_RS08400	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TW87_RS08410	COG0460	homoserine dehydrogenase
TW87_RS08420	COG3314	Sporulation integral membrane protein YlbJ
TW87_RS08425	COG2186	Transcriptional regulator
TW87_RS08430	COG3875	lactate racemase activity
TW87_RS08435	COG2086	electron transfer activity
TW87_RS08440	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
TW87_RS08445	COG0277	FAD linked oxidase domain protein
TW87_RS08450	COG1323	Belongs to the UPF0348 family
TW87_RS08455	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
TW87_RS08465	COG0333	Belongs to the bacterial ribosomal protein bL32 family
TW87_RS08470	COG2030	dehydratase
TW87_RS08475	COG0416	fatty acid biosynthetic process
TW87_RS08480	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TW87_RS08490	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TW87_RS08495	COG1028	Short-chain dehydrogenase reductase Sdr
TW87_RS08500	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TW87_RS08505	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TW87_RS08510	COG3706	GGDEF domain
TW87_RS08525	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
TW87_RS08540	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
TW87_RS08545	COG3854	ATPases associated with a variety of cellular activities
TW87_RS08585	COG1302	Protein conserved in bacteria
TW87_RS08590	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TW87_RS08595	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TW87_RS08600	COG1570	exodeoxyribonuclease VII activity
TW87_RS08615	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
TW87_RS08620	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TW87_RS08625	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
TW87_RS08630	COG0497	DNA recombination
TW87_RS08640	COG0456	acetyltransferase
TW87_RS08645	COG0456	acetyltransferase
TW87_RS08650	COG0750	zinc metalloprotease
TW87_RS08670	COG0463	Glycosyl transferase, family 2
TW87_RS08685	COG0494	nUDIX hydrolase
TW87_RS08695	COG4974	Belongs to the 'phage' integrase family
TW87_RS08700	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
TW87_RS08705	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TW87_RS08715	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
TW87_RS08720	COG4122	O-methyltransferase activity
TW87_RS08725	COG0826	peptidase U32
TW87_RS08730	COG0768	penicillin binding
TW87_RS08855	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TW87_RS08865	COG0571	ribonuclease III activity
TW87_RS08875	COG1196	nuclear chromosome segregation
TW87_RS08880	COG0552	protein localization to endoplasmic reticulum
TW87_RS08890	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TW87_RS08895	COG0228	four-way junction DNA binding
TW87_RS08905	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TW87_RS08910	COG0336	Belongs to the RNA methyltransferase TrmD family
TW87_RS08915	COG0335	large ribosomal subunit rRNA binding
TW87_RS08925	COG1114	Component of the transport system for branched-chain amino acids
TW87_RS08940	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TW87_RS08970	COG1131	(ABC) transporter
TW87_RS08975	COG2197	response regulator
TW87_RS08980	COG4585	Histidine kinase
TW87_RS08985	COG0792	nuclease activity
TW87_RS08990	COG0606	chelatase, subunit chli
TW87_RS08995	COG0758	DNA mediated transformation
TW87_RS09000	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TW87_RS09010	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TW87_RS09020	COG1959	2 iron, 2 sulfur cluster binding
TW87_RS09030	COG0822	iron-sulfur transferase activity
TW87_RS09035	COG0482	sulfurtransferase activity
TW87_RS09040	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TW87_RS09045	COG4472	Bacterial protein of unknown function (DUF965)
TW87_RS09055	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
TW87_RS09060	COG3906	Belongs to the UPF0473 family
TW87_RS09065	COG0735	belongs to the Fur family
TW87_RS09075	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
TW87_RS09085	COG1686	Belongs to the peptidase S11 family
TW87_RS09095	COG2207	Transcriptional regulator
TW87_RS09095	COG1917	Cupin 2, conserved barrel domain protein
TW87_RS09100	COG1994	Peptidase M50
TW87_RS09110	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TW87_RS09165	COG0779	Required for maturation of 30S ribosomal subunits
TW87_RS09170	COG0195	Participates in both transcription termination and antitermination
TW87_RS09175	COG2740	Nucleic-acid-binding protein implicated in transcription termination
TW87_RS09185	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TW87_RS09195	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TW87_RS09205	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TW87_RS09210	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TW87_RS09215	COG0196	riboflavin kinase activity
TW87_RS09225	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TW87_RS09230	COG1307	EDD domain protein, DegV family
TW87_RS09235	COG1185	polyribonucleotide nucleotidyltransferase activity
TW87_RS09240	COG0726	polysaccharide deacetylase
TW87_RS09245	COG0612	Peptidase, M16
TW87_RS09250	COG1873	PFAM PRC-barrel domain
TW87_RS09255	COG0527	aspartate kinase activity
TW87_RS09260	COG0740	serine-type endopeptidase activity
TW87_RS09270	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
TW87_RS09275	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TW87_RS09285	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TW87_RS09290	COG1418	mRNA catabolic process
TW87_RS09305	COG1968	undecaprenyl-diphosphatase activity
TW87_RS09315	COG0114	fumarate hydratase activity
TW87_RS09325	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TW87_RS09325	COG1263	PTS System
TW87_RS09335	COG1486	melibiose metabolic process
TW87_RS09340	COG0436	Aminotransferase
TW87_RS09350	COG0708	Exodeoxyribonuclease III
TW87_RS09365	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TW87_RS09390	COG1131	(ABC) transporter
TW87_RS09420	COG1278	Cold shock
TW87_RS09430	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TW87_RS09510	COG3299	homolog of phage Mu protein gp47
TW87_RS09515	COG3778	Protein conserved in bacteria
TW87_RS09560	COG1396	sequence-specific DNA binding
TW87_RS09565	COG2814	Major facilitator Superfamily
TW87_RS09575	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
TW87_RS09580	COG0471	metal ion transport
TW87_RS09580	COG3273	potassium ion transport
TW87_RS09585	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
TW87_RS09590	COG1914	H( )-stimulated, divalent metal cation uptake system
TW87_RS09595	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
TW87_RS09600	COG1984	allophanate hydrolase subunit 2
TW87_RS09605	COG1396	sequence-specific DNA binding
TW87_RS09610	COG4948	Mandelate Racemase Muconate Lactonizing
TW87_RS09655	COG1473	amidohydrolase
TW87_RS09660	COG1619	proteins homologs of microcin C7 resistance protein MccF
TW87_RS09675	COG0584	glycerophosphoryl diester phosphodiesterase
TW87_RS09695	COG0488	(ABC) transporter
TW87_RS09705	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TW87_RS09710	COG1181	Belongs to the D-alanine--D-alanine ligase family
TW87_RS09715	COG1546	Belongs to the CinA family
TW87_RS09715	COG1058	Belongs to the CinA family
TW87_RS09730	COG3829	transcription factor binding
TW87_RS09740	COG1242	4 iron, 4 sulfur cluster binding
TW87_RS09775	COG5002	protein histidine kinase activity
TW87_RS09775	COG3447	MASE1 domain protein
TW87_RS09775	COG5001	Diguanylate cyclase
TW87_RS09780	COG2203	Gaf domain
TW87_RS09780	COG2199	diguanylate cyclase activity
TW87_RS09790	COG0789	Transcriptional regulator
TW87_RS09790	COG4978	Transcriptional regulator
TW87_RS09805	COG1285	pathogenesis
TW87_RS09810	COG1335	isochorismatase
TW87_RS09830	COG0726	polysaccharide deacetylase
TW87_RS09845	COG0450	alkyl hydroperoxide reductase
TW87_RS09860	COG2720	vancomycin resistance protein
TW87_RS09865	COG3829	transcription factor binding
TW87_RS09880	COG1346	cytolysis
TW87_RS09885	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
TW87_RS09905	COG0512	Glutamine amidotransferase of anthranilate synthase
TW87_RS09910	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TW87_RS09915	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TW87_RS09925	COG0302	gtp cyclohydrolase
TW87_RS09930	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TW87_RS09935	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
TW87_RS09940	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
TW87_RS09945	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TW87_RS09950	COG0358	DNA primase activity
TW87_RS09955	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TW87_RS09960	COG2384	SAM-dependent methyltransferase
TW87_RS09965	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TW87_RS09970	COG0655	NAD(P)H dehydrogenase (quinone) activity
TW87_RS10015	COG1674	ftsk spoiiie
TW87_RS10020	COG2946	Replication initiation factor
TW87_RS10035	COG0596	Alpha beta hydrolase
TW87_RS10065	COG0741	lytic transglycosylase activity
TW87_RS10065	COG0791	NLP P60 protein
TW87_RS10075	COG1309	transcriptional regulator
TW87_RS10090	COG5002	protein histidine kinase activity
TW87_RS10115	COG1136	(ABC) transporter
TW87_RS10145	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TW87_RS10160	COG3850	Histidine kinase
TW87_RS10160	COG5002	protein histidine kinase activity
TW87_RS10165	COG1136	(ABC) transporter
TW87_RS10165	COG0577	efflux transmembrane transporter activity
TW87_RS10195	COG1132	(ABC) transporter
TW87_RS10200	COG1132	(ABC) transporter
TW87_RS10205	COG1592	Rubrerythrin
TW87_RS10205	COG1773	rubredoxin
TW87_RS10210	COG0412	Dienelactone hydrolase
TW87_RS10245	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TW87_RS10280	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
TW87_RS10285	COG2011	ABC-type metal ion transport system permease component
TW87_RS10295	COG5002	protein histidine kinase activity
TW87_RS10300	COG2094	Belongs to the DNA glycosylase MPG family
TW87_RS10305	COG1396	sequence-specific DNA binding
TW87_RS10310	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TW87_RS10315	COG4086	secreted protein
TW87_RS10330	COG0728	peptidoglycan biosynthetic process
TW87_RS10345	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
TW87_RS10355	COG1131	(ABC) transporter
TW87_RS10365	COG0534	Mate efflux family protein
TW87_RS10380	COG0348	domain, Protein
TW87_RS10380	COG3901	Regulator of nitric oxide reductase transcription
TW87_RS10405	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
TW87_RS10410	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
TW87_RS10420	COG5001	Diguanylate cyclase
TW87_RS10430	COG4978	Transcriptional regulator
TW87_RS10430	COG0789	Transcriptional regulator
TW87_RS10435	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
TW87_RS10455	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TW87_RS10460	COG0726	polysaccharide deacetylase
TW87_RS10470	COG1592	Rubrerythrin
TW87_RS10470	COG1773	rubredoxin
TW87_RS10480	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TW87_RS10485	COG0577	efflux transmembrane transporter activity
TW87_RS10490	COG0577	efflux transmembrane transporter activity
TW87_RS10490	COG1136	(ABC) transporter
TW87_RS10500	COG2205	protein histidine kinase activity
TW87_RS10505	COG0745	RESPONSE REGULATOR receiver
TW87_RS10510	COG1136	(ABC) transporter
TW87_RS10515	COG0577	efflux transmembrane transporter activity
TW87_RS10520	COG0405	Gamma-glutamyltransferase
TW87_RS10535	COG0493	'glutamate synthase
TW87_RS10535	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
TW87_RS10545	COG1136	(ABC) transporter
TW87_RS10550	COG0577	efflux transmembrane transporter activity
TW87_RS10590	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
TW87_RS10595	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
TW87_RS10600	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TW87_RS10605	COG0131	Imidazoleglycerol-phosphate dehydratase
TW87_RS10610	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TW87_RS10615	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
TW87_RS10620	COG0107	imidazoleglycerol-phosphate synthase activity
TW87_RS10625	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TW87_RS10625	COG0140	phosphoribosyl-ATP diphosphatase activity
TW87_RS10630	COG0531	amino acid
TW87_RS10645	COG1595	DNA-templated transcription, initiation
TW87_RS10660	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
TW87_RS10675	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TW87_RS10680	COG0028	Belongs to the TPP enzyme family
TW87_RS10685	COG3546	catalase activity
TW87_RS10690	COG1331	Highly conserved protein containing a thioredoxin domain
TW87_RS10700	COG2267	carboxylic ester hydrolase activity
TW87_RS10715	COG3584	3D domain protein
TW87_RS10715	COG1388	LysM domain
TW87_RS10725	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TW87_RS10730	COG1295	ribonuclease BN
TW87_RS10735	COG5002	protein histidine kinase activity
TW87_RS10740	COG0460	homoserine dehydrogenase
TW87_RS10750	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
TW87_RS10755	COG2267	carboxylic ester hydrolase activity
TW87_RS10760	COG5566	PFAM Mor transcription activator
TW87_RS10770	COG2971	BadF BadG BcrA BcrD
TW87_RS10780	COG1129	ABC transporter
TW87_RS10785	COG1172	Belongs to the binding-protein-dependent transport system permease family
TW87_RS10795	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
TW87_RS10800	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
TW87_RS10805	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
TW87_RS10810	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
TW87_RS10815	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TW87_RS10820	COG1045	serine acetyltransferase
TW87_RS10825	COG1141	Ferredoxin
TW87_RS10845	COG0351	phosphomethylpyrimidine kinase
TW87_RS10850	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
TW87_RS10855	COG0352	thiamine-phosphate diphosphorylase activity
TW87_RS10860	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
TW87_RS10880	COG1725	Transcriptional regulator
TW87_RS10910	COG0402	S-adenosylhomocysteine deaminase activity
TW87_RS10920	COG4555	ABC transporter
TW87_RS10925	COG1668	transmembrane transport
TW87_RS10930	COG3300	MHYT domain
TW87_RS10930	COG5001	Diguanylate cyclase
TW87_RS10935	COG1725	Transcriptional regulator
TW87_RS10940	COG1131	(ABC) transporter
TW87_RS10955	COG0668	transmembrane transport
TW87_RS10965	COG0426	domain, Protein
TW87_RS10980	COG1181	Belongs to the D-alanine--D-alanine ligase family
TW87_RS10985	COG1876	peptidase activity
TW87_RS11010	COG0367	asparagine synthase
TW87_RS11015	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TW87_RS11030	COG2310	stress, protein
TW87_RS11045	COG3853	Toxic anion resistance protein (TelA)
TW87_RS11075	COG5505	Protein of unknown function (DUF819)
TW87_RS11085	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TW87_RS11090	COG4605	iron ion homeostasis
TW87_RS11095	COG4604	ABC transporter, ATP-binding protein
TW87_RS11100	COG4607	ABC-type enterochelin transport system periplasmic component
TW87_RS11105	COG3706	GGDEF domain
TW87_RS11105	COG2203	Gaf domain
TW87_RS11105	COG5001	Diguanylate cyclase
TW87_RS11105	COG4251	negative regulation of phosphorylation
TW87_RS11120	COG0095	Lipoate-protein ligase
TW87_RS11125	COG1757	Na H antiporter
TW87_RS11140	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TW87_RS11145	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TW87_RS11150	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
TW87_RS11155	COG3123	guanosine phosphorylase activity
TW87_RS11175	COG0402	S-adenosylhomocysteine deaminase activity
TW87_RS11185	COG1396	sequence-specific DNA binding
TW87_RS11195	COG0584	glycerophosphoryl diester phosphodiesterase
TW87_RS11215	COG1131	(ABC) transporter
TW87_RS11225	COG0745	RESPONSE REGULATOR receiver
TW87_RS11230	COG2205	protein histidine kinase activity
TW87_RS11245	COG1733	regulation of RNA biosynthetic process
TW87_RS11250	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
TW87_RS11280	COG1309	transcriptional regulator
TW87_RS11315	COG0745	RESPONSE REGULATOR receiver
TW87_RS11320	COG5002	protein histidine kinase activity
TW87_RS11325	COG3118	belongs to the thioredoxin family
TW87_RS11355	COG1115	amino acid carrier protein
TW87_RS11365	COG1263	PTS System
TW87_RS11365	COG2190	(PTS) system
TW87_RS11365	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TW87_RS11370	COG0363	glucosamine-6-phosphate deaminase activity
TW87_RS11375	COG0436	Aminotransferase
TW87_RS11400	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TW87_RS11400	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TW87_RS11420	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
TW87_RS11435	COG2022	thiamine diphosphate biosynthetic process
TW87_RS11440	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TW87_RS11450	COG1288	antiporter activity
TW87_RS11470	COG0393	Putative heavy-metal-binding
TW87_RS11475	COG0521	Mo-molybdopterin cofactor biosynthetic process
TW87_RS11485	COG0315	cyclic pyranopterin monophosphate synthase activity
TW87_RS11565	COG1283	sodium-dependent phosphate transmembrane transporter activity
TW87_RS11590	COG5012	cobalamin binding
TW87_RS11595	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
TW87_RS11605	COG1011	Hydrolase
TW87_RS11610	COG1396	sequence-specific DNA binding
TW87_RS11610	COG1917	Cupin 2, conserved barrel domain protein
TW87_RS11615	COG2610	gluconate transmembrane transporter activity
TW87_RS11620	COG5002	protein histidine kinase activity
TW87_RS11625	COG2204	response regulator
TW87_RS11670	COG0786	glutamate:sodium symporter activity
TW87_RS11685	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
TW87_RS11690	COG1924	4 iron, 4 sulfur cluster binding
TW87_RS11695	COG2247	cell wall binding repeat
TW87_RS11695	COG2385	sporulation resulting in formation of a cellular spore
TW87_RS11705	COG1309	transcriptional regulator
TW87_RS11730	COG0242	peptide deformylase activity
TW87_RS11765	COG3326	Membrane
TW87_RS11775	COG0494	nUDIX hydrolase
TW87_RS11820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TW87_RS11825	COG0765	amino acid transport
TW87_RS11835	COG1393	Belongs to the ArsC family
TW87_RS11845	COG1606	tRNA processing
TW87_RS11850	COG0116	Belongs to the methyltransferase superfamily
TW87_RS11865	COG5002	protein histidine kinase activity
TW87_RS11865	COG3850	Histidine kinase
TW87_RS11875	COG0137	argininosuccinate synthase activity
TW87_RS11885	COG0789	Transcriptional regulator
TW87_RS11895	COG2323	membrane
TW87_RS11910	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TW87_RS11935	COG0446	pyridine nucleotide-disulphide oxidoreductase
TW87_RS11940	COG0583	DNA-binding transcription factor activity
TW87_RS11955	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
TW87_RS11970	COG1609	Transcriptional regulator
TW87_RS11975	COG1621	beta-fructofuranosidase activity
TW87_RS11980	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TW87_RS11995	COG2814	Major facilitator Superfamily
TW87_RS12025	COG0406	alpha-ribazole phosphatase activity
TW87_RS12030	COG2081	HI0933 family
TW87_RS12035	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
TW87_RS12040	COG0204	Acyl-transferase
TW87_RS12045	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TW87_RS12065	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
TW87_RS12070	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TW87_RS12075	COG3022	response to hydroperoxide
TW87_RS12090	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
TW87_RS12095	COG1846	Transcriptional regulator
TW87_RS12100	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TW87_RS12105	COG2205	protein histidine kinase activity
TW87_RS12115	COG0598	Magnesium transport protein CorA
TW87_RS12125	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TW87_RS12130	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TW87_RS12135	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TW87_RS12140	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TW87_RS12145	COG1605	Chorismate mutase
TW87_RS12145	COG0077	Prephenate dehydratase
TW87_RS12150	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TW87_RS12160	COG0287	Prephenate dehydrogenase
TW87_RS12170	COG3706	GGDEF domain
TW87_RS12195	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TW87_RS12200	COG2226	methyltransferase
TW87_RS12205	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
TW87_RS12235	COG2131	deaminase
TW87_RS12280	COG1720	tRNA m6t6A37 methyltransferase activity
TW87_RS12290	COG2207	Transcriptional regulator
TW87_RS12290	COG3708	Transcriptional regulator
TW87_RS12300	COG0791	NLP P60 protein
TW87_RS12300	COG0741	lytic transglycosylase activity
TW87_RS12385	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TW87_RS12430	COG4303	Ethanolamine ammonia lyase large subunit
TW87_RS12435	COG4302	ethanolamine ammonia-lyase activity
TW87_RS12450	COG1454	alcohol dehydrogenase
TW87_RS12450	COG1012	belongs to the aldehyde dehydrogenase family
TW87_RS12465	COG4869	propanediol catabolic process
TW87_RS12475	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
TW87_RS12485	COG3192	ethanolamine utilization protein
TW87_RS12490	COG4766	ethanolamine catabolic process
TW87_RS12500	COG1473	amidohydrolase
TW87_RS12505	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
TW87_RS12510	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
TW87_RS12515	COG1116	anion transmembrane transporter activity
TW87_RS12535	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TW87_RS12540	COG4974	Belongs to the 'phage' integrase family
TW87_RS12555	COG2359	stage V sporulation protein S
TW87_RS12560	COG0825	malonyl-CoA metabolic process
TW87_RS12565	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
TW87_RS12570	COG0439	Biotin carboxylase
TW87_RS12575	COG0511	ligase activity, forming carbon-carbon bonds
TW87_RS12595	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TW87_RS12620	COG1136	(ABC) transporter
TW87_RS12630	COG2205	protein histidine kinase activity
TW87_RS12635	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
TW87_RS12640	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TW87_RS12660	COG1136	(ABC) transporter
TW87_RS12665	COG2205	protein histidine kinase activity
TW87_RS12670	COG0745	RESPONSE REGULATOR receiver
TW87_RS12680	COG0745	RESPONSE REGULATOR receiver
TW87_RS12685	COG5002	protein histidine kinase activity
TW87_RS12690	COG1136	(ABC) transporter
TW87_RS12690	COG0577	efflux transmembrane transporter activity
TW87_RS12725	COG1811	Na channel or pump
TW87_RS12730	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
TW87_RS12745	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TW87_RS12750	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
TW87_RS12755	COG1923	regulation of RNA biosynthetic process
TW87_RS12760	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TW87_RS12765	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TW87_RS12770	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TW87_RS12775	COG1116	anion transmembrane transporter activity
TW87_RS12780	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TW87_RS12785	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TW87_RS12800	COG1733	regulation of RNA biosynthetic process
TW87_RS12805	COG0384	phenazine biosynthesis protein PhzF
TW87_RS12810	COG0494	nUDIX hydrolase
TW87_RS12820	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TW87_RS12825	COG0860	N-Acetylmuramoyl-L-alanine amidase
TW87_RS12825	COG2247	cell wall binding repeat
TW87_RS12885	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
TW87_RS12905	COG0730	response to heat
TW87_RS12910	COG2207	Transcriptional regulator
TW87_RS12915	COG0596	Alpha beta hydrolase
TW87_RS12920	COG1309	transcriptional regulator
TW87_RS12935	COG1404	Belongs to the peptidase S8 family
TW87_RS12980	COG2207	Transcriptional regulator
TW87_RS12985	COG2814	Major facilitator Superfamily
TW87_RS13005	COG1725	Transcriptional regulator
TW87_RS13030	COG1794	racemase activity, acting on amino acids and derivatives
TW87_RS13040	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TW87_RS13045	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TW87_RS13050	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TW87_RS13055	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
TW87_RS13065	COG0456	acetyltransferase
TW87_RS13075	COG1309	transcriptional regulator
TW87_RS13095	COG3655	Transcriptional regulator
TW87_RS13110	COG0745	RESPONSE REGULATOR receiver
TW87_RS13115	COG1737	Transcriptional regulator
TW87_RS13120	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
TW87_RS13125	COG1187	pseudouridine synthase activity
TW87_RS13130	COG0628	permease
TW87_RS13145	COG0527	aspartate kinase activity
TW87_RS13175	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TW87_RS13210	COG0582	viral genome integration into host DNA
TW87_RS13220	COG0488	(ABC) transporter
TW87_RS13235	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TW87_RS13245	COG1529	Aldehyde oxidase and xanthine dehydrogenase
TW87_RS13245	COG2080	2 iron, 2 sulfur cluster binding
TW87_RS13255	COG2233	PERMEase
TW87_RS13265	COG0167	dihydroorotate dehydrogenase activity
TW87_RS13270	COG0402	S-adenosylhomocysteine deaminase activity
TW87_RS13290	COG0402	S-adenosylhomocysteine deaminase activity
TW87_RS13315	COG1529	Aldehyde oxidase and xanthine dehydrogenase
TW87_RS13340	COG3829	transcription factor binding
TW87_RS13350	COG1401	restriction endodeoxyribonuclease activity
TW87_RS13365	COG4708	membrane
TW87_RS13375	COG2080	2 iron, 2 sulfur cluster binding
TW87_RS13375	COG1529	Aldehyde oxidase and xanthine dehydrogenase
TW87_RS13410	COG1131	(ABC) transporter
TW87_RS13420	COG2252	PERMEase
TW87_RS13425	COG0534	Mate efflux family protein
TW87_RS13435	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TW87_RS13440	COG1349	DNA-binding transcription factor activity
TW87_RS13450	COG5002	protein histidine kinase activity
TW87_RS13455	COG0745	RESPONSE REGULATOR receiver
TW87_RS13460	COG2217	Heavy metal translocating P-type atpase
TW87_RS13475	COG1217	gtp-binding protein TYPA
TW87_RS13480	COG0492	ferredoxin-NADP+ reductase activity
TW87_RS13520	COG1247	-acetyltransferase
TW87_RS13540	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TW87_RS13545	COG0750	zinc metalloprotease
TW87_RS13550	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TW87_RS13575	COG4589	Belongs to the CDS family
TW87_RS13590	COG0233	cytoplasmic translational termination
TW87_RS13595	COG0528	UMP kinase activity
TW87_RS13600	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TW87_RS13605	COG0052	Belongs to the universal ribosomal protein uS2 family
TW87_RS13610	COG1686	Belongs to the peptidase S11 family
TW87_RS13625	COG1971	Probably functions as a manganese efflux pump
TW87_RS13630	COG1193	negative regulation of DNA recombination
TW87_RS13645	COG2720	vancomycin resistance protein
TW87_RS13665	COG1363	Peptidase, m42
TW87_RS13675	COG1160	GTP binding
TW87_RS13680	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TW87_RS13730	COG0039	L-malate dehydrogenase activity
TW87_RS13740	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TW87_RS13740	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TW87_RS13750	COG1151	hydroxylamine reductase activity
TW87_RS13770	COG1301	dicarboxylic acid transport
TW87_RS13775	COG1126	abc transporter atp-binding protein
TW87_RS13800	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TW87_RS13805	COG0437	4 iron, 4 sulfur cluster binding
TW87_RS13815	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TW87_RS13820	COG0596	Alpha beta hydrolase
TW87_RS13830	COG0513	Belongs to the DEAD box helicase family
TW87_RS13850	COG1705	Flagellar rod assembly protein muramidase FlgJ
TW87_RS13855	COG1554	hydrolase, family 65, central catalytic
TW87_RS13860	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TW87_RS13870	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TW87_RS13880	COG2247	cell wall binding repeat
TW87_RS13880	COG2385	sporulation resulting in formation of a cellular spore
TW87_RS13890	COG1528	Iron-storage protein
TW87_RS13910	COG0674	pyruvate-flavodoxin oxidoreductase activity
TW87_RS13910	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TW87_RS13920	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TW87_RS13935	COG1309	transcriptional regulator
TW87_RS13945	COG0628	permease
TW87_RS13950	COG1012	belongs to the aldehyde dehydrogenase family
TW87_RS13965	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TW87_RS13990	COG0288	reversible hydration of carbon dioxide
TW87_RS14010	COG0710	3-dehydroquinate dehydratase activity
TW87_RS14015	COG0582	viral genome integration into host DNA
TW87_RS14040	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TW87_RS14070	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TW87_RS14125	COG1674	ftsk spoiiie
TW87_RS14130	COG2946	Replication initiation factor
TW87_RS14180	COG0741	lytic transglycosylase activity
TW87_RS14180	COG0791	NLP P60 protein
TW87_RS14220	COG1733	regulation of RNA biosynthetic process
TW87_RS14225	COG1335	isochorismatase
TW87_RS14230	COG1733	regulation of RNA biosynthetic process
TW87_RS14245	COG0745	RESPONSE REGULATOR receiver
TW87_RS14310	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TW87_RS14315	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TW87_RS14320	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
TW87_RS14335	COG2203	Gaf domain
TW87_RS14335	COG5001	Diguanylate cyclase
TW87_RS14335	COG4251	negative regulation of phosphorylation
TW87_RS14335	COG3706	GGDEF domain
TW87_RS14340	COG0017	Asparaginyl-tRNA synthetase
TW87_RS14350	COG1404	Belongs to the peptidase S8 family
TW87_RS14355	COG1404	Belongs to the peptidase S8 family
TW87_RS14365	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TW87_RS14380	COG1509	lysine 2,3-aminomutase activity
TW87_RS14385	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TW87_RS14390	COG1794	racemase activity, acting on amino acids and derivatives
TW87_RS14410	COG0662	Cupin 2, conserved barrel domain protein
TW87_RS14415	COG3104	oligopeptide transport
TW87_RS14420	COG0006	proline dipeptidase activity
TW87_RS14425	COG3104	oligopeptide transport
TW87_RS14430	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TW87_RS14445	COG0723	plastoquinol--plastocyanin reductase activity
TW87_RS14445	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TW87_RS14455	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TW87_RS14455	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TW87_RS14455	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TW87_RS14460	COG1105	Belongs to the carbohydrate kinase PfkB family
TW87_RS14465	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TW87_RS14465	COG3711	transcriptional antiterminator
TW87_RS14470	COG2365	Tyrosine phosphatase family
TW87_RS14490	COG1115	amino acid carrier protein
TW87_RS14495	COG0235	Class ii aldolase
TW87_RS14500	COG0235	Class ii aldolase
TW87_RS14505	COG1063	alcohol dehydrogenase
TW87_RS14510	COG3775	system Galactitol-specific IIC component
TW87_RS14515	COG3414	Phosphotransferase system galactitol-specific IIB component
TW87_RS14520	COG2213	PTS system mannitol-specific
TW87_RS14520	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
TW87_RS14525	COG3933	PFAM sigma-54 factor interaction domain-containing protein
TW87_RS14525	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
TW87_RS14535	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TW87_RS14540	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
TW87_RS14550	COG5002	protein histidine kinase activity
TW87_RS14605	COG3617	BRO family, N-terminal domain
TW87_RS14665	COG3620	sequence-specific DNA binding
TW87_RS14690	COG3842	ATPase activity
TW87_RS14710	COG2205	protein histidine kinase activity
TW87_RS14715	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TW87_RS14720	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TW87_RS14725	COG0698	ribose 5-phosphate isomerase
TW87_RS14730	COG3958	Transketolase
TW87_RS14735	COG3959	Transketolase, thiamine diphosphate binding domain
TW87_RS14750	COG3775	system Galactitol-specific IIC component
TW87_RS14755	COG3414	Phosphotransferase system galactitol-specific IIB component
TW87_RS14765	COG3933	PFAM sigma-54 factor interaction domain-containing protein
TW87_RS14765	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
TW87_RS14770	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TW87_RS14775	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
TW87_RS14780	COG0246	Mannitol dehydrogenase
TW87_RS14785	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
TW87_RS14790	COG3711	transcriptional antiterminator
TW87_RS14800	COG0516	GMP reductase activity
TW87_RS14800	COG0517	IMP dehydrogenase activity
TW87_RS14810	COG2801	Transposase and inactivated derivatives
TW87_RS14815	COG3853	Toxic anion resistance protein (TelA)
TW87_RS14825	COG1454	alcohol dehydrogenase
TW87_RS14830	COG0427	acetyl-CoA hydrolase
TW87_RS14845	COG1012	belongs to the aldehyde dehydrogenase family
TW87_RS14850	COG0427	acetyl-CoA hydrolase
TW87_RS14855	COG2985	domain, Protein
TW87_RS14855	COG0490	domain, Protein
TW87_RS14855	COG0490	domain, Protein
TW87_RS14855	COG2985	domain, Protein
TW87_RS14860	COG0583	DNA-binding transcription factor activity
TW87_RS14870	COG0006	proline dipeptidase activity
TW87_RS14885	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
TW87_RS14910	COG3118	belongs to the thioredoxin family
TW87_RS14930	COG0561	phosphatase activity
TW87_RS14945	COG1116	anion transmembrane transporter activity
TW87_RS14955	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TW87_RS14995	COG0157	Belongs to the NadC ModD family
TW87_RS15005	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
TW87_RS15010	COG1966	Carbon starvation protein
TW87_RS15025	COG0628	permease
TW87_RS15035	COG2364	Membrane
TW87_RS15040	COG3426	butyrate kinase activity
TW87_RS15065	COG2199	diguanylate cyclase activity
TW87_RS15110	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TW87_RS15110	COG0072	phenylalanine-tRNA ligase activity
TW87_RS15115	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
TW87_RS15120	COG2176	DNA-directed DNA polymerase activity
TW87_RS15140	COG0037	tRNA processing
TW87_RS15155	COG3546	catalase activity
TW87_RS15160	COG3103	Sh3 type 3 domain protein
TW87_RS15160	COG0791	NLP P60 protein
TW87_RS15160	COG1388	LysM domain
TW87_RS15170	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TW87_RS15170	COG0551	DNA topoisomerase type I activity
TW87_RS15200	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TW87_RS15200	COG0574	Belongs to the PEP-utilizing enzyme family
TW87_RS15205	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
TW87_RS15210	COG0517	IMP dehydrogenase activity
TW87_RS15230	COG3711	transcriptional antiterminator
TW87_RS15230	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TW87_RS15235	COG3732	PTS system glucitol sorbitol-specific
TW87_RS15245	COG2207	Transcriptional regulator
TW87_RS15260	COG1115	amino acid carrier protein
TW87_RS15265	COG2223	nitrite transmembrane transporter activity
TW87_RS15270	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TW87_RS15275	COG0280	phosphate acetyltransferase
TW87_RS15305	COG1414	Transcriptional regulator
TW87_RS15315	COG0751	glycine-tRNA ligase activity
TW87_RS15320	COG0752	glycyl-tRNA synthetase alpha subunit
TW87_RS15330	COG1381	Involved in DNA repair and RecF pathway recombination
TW87_RS15340	COG2239	Acts as a magnesium transporter
TW87_RS15345	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TW87_RS15350	COG0295	cytidine deaminase activity
TW87_RS15355	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
TW87_RS15360	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TW87_RS15365	COG1702	phosphate starvation-inducible protein PhoH
TW87_RS15385	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
TW87_RS15390	COG1610	YqeY-like protein
TW87_RS15395	COG0828	Belongs to the bacterial ribosomal protein bS21 family
TW87_RS15400	COG0537	adenosine 5'-monophosphoramidase activity
TW87_RS15405	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TW87_RS15410	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TW87_RS15415	COG2264	protein methyltransferase activity
TW87_RS15445	COG3842	ATPase activity
TW87_RS15450	COG2508	Transcriptional regulator
TW87_RS15455	COG0477	Major facilitator Superfamily
TW87_RS15470	COG0484	heat shock protein binding
TW87_RS15475	COG0443	Heat shock 70 kDa protein
TW87_RS15480	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TW87_RS15485	COG1420	regulation of RNA biosynthetic process
TW87_RS15490	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TW87_RS15495	COG0531	amino acid
TW87_RS15500	COG0617	tRNA 3'-terminal CCA addition
TW87_RS15505	COG0481	GTPase activity
TW87_RS15535	COG0268	Binds directly to 16S ribosomal RNA
TW87_RS15545	COG2333	competence protein COMEC
TW87_RS15545	COG0658	competence protein
TW87_RS15565	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
TW87_RS15570	COG3584	3D domain protein
TW87_RS15570	COG1388	LysM domain
TW87_RS15575	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
TW87_RS15590	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
TW87_RS15595	COG0006	proline dipeptidase activity
TW87_RS15600	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TW87_RS15605	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TW87_RS15615	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TW87_RS15615	COG3711	transcriptional antiterminator
TW87_RS15620	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TW87_RS15625	COG1482	cell wall glycoprotein biosynthetic process
TW87_RS15645	COG0709	Synthesizes selenophosphate from selenide and ATP
TW87_RS15650	COG1555	photosystem II stabilization
TW87_RS15650	COG1596	polysaccharide export
TW87_RS15655	COG1686	Belongs to the peptidase S11 family
TW87_RS15665	COG0165	Argininosuccinate lyase
TW87_RS15670	COG0561	phosphatase activity
TW87_RS15675	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TW87_RS15680	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
TW87_RS15685	COG1876	peptidase activity
TW87_RS15690	COG1309	transcriptional regulator
TW87_RS15695	COG2814	Major facilitator Superfamily
TW87_RS15705	COG4977	sequence-specific DNA binding
TW87_RS15715	COG1263	PTS System
TW87_RS15715	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TW87_RS15720	COG3711	transcriptional antiterminator
TW87_RS15725	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TW87_RS15725	COG1263	PTS System
TW87_RS15725	COG2190	(PTS) system
TW87_RS15730	COG0251	oxidation-reduction process
TW87_RS15735	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
TW87_RS15770	COG0582	viral genome integration into host DNA
TW87_RS15780	COG0495	leucyl-tRNA aminoacylation
TW87_RS15785	COG0799	negative regulation of ribosome biogenesis
TW87_RS15790	COG1713	HD superfamily hydrolase involved in NAD metabolism
TW87_RS15795	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TW87_RS15800	COG2137	regulation of response to DNA damage stimulus
TW87_RS15805	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
TW87_RS15825	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
TW87_RS15835	COG0577	efflux transmembrane transporter activity
TW87_RS15835	COG1136	(ABC) transporter
TW87_RS15845	COG0745	RESPONSE REGULATOR receiver
TW87_RS15850	COG0737	Belongs to the 5'-nucleotidase family
TW87_RS15860	COG1234	tRNA 3'-trailer cleavage
TW87_RS15865	COG0446	pyridine nucleotide-disulphide oxidoreductase
TW87_RS15870	COG1823	symporter activity
TW87_RS15895	COG4124	Belongs to the glycosyl hydrolase 26 family
TW87_RS15895	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
TW87_RS15905	COG0395	ABC-type sugar transport system, permease component
TW87_RS15920	COG4821	SIS domain
TW87_RS15955	COG0742	ribosomal rna small subunit methyltransferase
TW87_RS15960	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TW87_RS15965	COG1461	Dihydroxyacetone kinase
TW87_RS15970	COG1302	Protein conserved in bacteria
TW87_RS15975	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TW87_RS15990	COG0789	Transcriptional regulator
TW87_RS15995	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TW87_RS15995	COG3711	transcriptional antiterminator
TW87_RS16000	COG3711	transcriptional antiterminator
TW87_RS16000	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TW87_RS16005	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TW87_RS16010	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TW87_RS16015	COG0383	alpha-mannosidase activity
TW87_RS16040	COG1564	THIamine pyrophosphokinase
TW87_RS16045	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TW87_RS16050	COG1162	GTPase activity
TW87_RS16055	COG1028	Short-chain dehydrogenase reductase Sdr
TW87_RS16060	COG2815	serine threonine protein kinase
TW87_RS16060	COG0515	serine threonine protein kinase
TW87_RS16070	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TW87_RS16075	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TW87_RS16075	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TW87_RS16080	COG2738	Putative neutral zinc metallopeptidase
TW87_RS16090	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TW87_RS16095	COG0242	peptide deformylase activity
TW87_RS16100	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TW87_RS16105	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TW87_RS16110	COG1758	RNA polymerase activity
TW87_RS16115	COG0194	GDP metabolic process
TW87_RS16120	COG1561	YicC-like family, N-terminal region
TW87_RS16125	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
TW87_RS16135	COG1293	RNA-binding protein homologous to eukaryotic snRNP
TW87_RS16140	COG0488	(ABC) transporter
TW87_RS16150	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
TW87_RS16155	COG0564	pseudouridine synthase activity
TW87_RS16160	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
TW87_RS16170	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
TW87_RS16175	COG1966	Carbon starvation protein
TW87_RS16180	COG3279	Response regulator of the LytR AlgR family
TW87_RS16185	COG3275	phosphorelay sensor kinase activity
TW87_RS16220	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TW87_RS16225	COG0531	amino acid
TW87_RS16230	COG0006	proline dipeptidase activity
TW87_RS16235	COG1307	EDD domain protein, DegV family
TW87_RS16250	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
TW87_RS16255	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TW87_RS16265	COG2302	S4 RNA-binding domain
TW87_RS16275	COG1799	cell septum assembly
TW87_RS16280	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
TW87_RS16300	COG3830	Belongs to the UPF0237 family
TW87_RS16310	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
TW87_RS16315	COG2271	Major facilitator Superfamily
TW87_RS16320	COG0531	amino acid
TW87_RS16325	COG0006	proline dipeptidase activity
TW87_RS16335	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TW87_RS16340	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TW87_RS16345	COG1160	GTP binding
TW87_RS16370	COG5002	protein histidine kinase activity
TW87_RS16375	COG0745	RESPONSE REGULATOR receiver
TW87_RS16385	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TW87_RS16390	COG1873	PFAM PRC-barrel domain
TW87_RS16395	COG1191	sigma factor activity
TW87_RS16400	COG1191	sigma factor activity
TW87_RS16415	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TW87_RS16420	COG3856	small basic protein
TW87_RS16440	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TW87_RS16445	COG0772	Belongs to the SEDS family
TW87_RS16450	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TW87_RS16455	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TW87_RS16460	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TW87_RS16465	COG0768	penicillin binding
TW87_RS16475	COG0275	rRNA processing
TW87_RS16480	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
TW87_RS16485	COG0612	Peptidase, M16
TW87_RS16495	COG0012	GTP binding
TW87_RS16505	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TW87_RS16515	COG2190	(PTS) system
TW87_RS16515	COG1263	PTS System
TW87_RS16515	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TW87_RS16520	COG3711	transcriptional antiterminator
TW87_RS16525	COG0025	NhaP-type Na H and K H
TW87_RS16530	COG4608	Belongs to the ABC transporter superfamily
TW87_RS16535	COG0444	Belongs to the ABC transporter superfamily
TW87_RS16545	COG0601	transmembrane transport
TW87_RS16550	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TW87_RS16555	COG0583	DNA-binding transcription factor activity
TW87_RS16560	COG0183	Belongs to the thiolase family
TW87_RS16565	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
TW87_RS16575	COG1028	Short-chain dehydrogenase reductase Sdr
TW87_RS16580	COG2610	gluconate transmembrane transporter activity
TW87_RS16585	COG2340	Cysteine-rich secretory protein family
TW87_RS16595	COG4869	propanediol catabolic process
TW87_RS16630	COG2081	HI0933 family
TW87_RS16635	COG0671	phosphoesterase, PA-phosphatase related
TW87_RS16645	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TW87_RS16660	COG2502	aspartate--ammonia ligase
TW87_RS16665	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
TW87_RS16670	COG1473	amidohydrolase
TW87_RS16680	COG3366	ferrous iron transmembrane transporter activity
TW87_RS16705	COG2252	PERMEase
TW87_RS16710	COG0402	S-adenosylhomocysteine deaminase activity
TW87_RS16720	COG2271	Major facilitator Superfamily
TW87_RS16740	COG0583	DNA-binding transcription factor activity
TW87_RS16750	COG1376	ErfK ybiS ycfS ynhG family protein
TW87_RS16755	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
TW87_RS16760	COG1210	Utp--glucose-1-phosphate uridylyltransferase
TW87_RS16785	COG4509	Sortase family
TW87_RS16805	COG0726	polysaccharide deacetylase
TW87_RS16810	COG3069	C4-dicarboxylate transmembrane transporter activity
TW87_RS16815	COG5002	protein histidine kinase activity
TW87_RS16815	COG0642	Histidine kinase
TW87_RS16820	COG0745	RESPONSE REGULATOR receiver
TW87_RS16835	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TW87_RS16840	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TW87_RS16860	COG1937	Protein conserved in bacteria
TW87_RS16875	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
TW87_RS16880	COG1757	Na H antiporter
TW87_RS16890	COG2247	cell wall binding repeat
TW87_RS16890	COG0860	N-Acetylmuramoyl-L-alanine amidase
TW87_RS16895	COG0583	DNA-binding transcription factor activity
TW87_RS16900	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TW87_RS16910	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
TW87_RS16915	COG0124	histidyl-tRNA synthetase
TW87_RS16920	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TW87_RS16925	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TW87_RS16930	COG1490	D-aminoacyl-tRNA deacylase activity
TW87_RS16935	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TW87_RS16940	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
TW87_RS16945	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TW87_RS16945	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
TW87_RS16985	COG5001	Diguanylate cyclase
TW87_RS16990	COG3706	GGDEF domain
TW87_RS17000	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
TW87_RS17025	COG0860	N-Acetylmuramoyl-L-alanine amidase
TW87_RS17030	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TW87_RS17040	COG0561	phosphatase activity
TW87_RS17045	COG1316	TRANSCRIPTIONal
TW87_RS17050	COG1316	TRANSCRIPTIONal
TW87_RS17055	COG1649	PFAM Uncharacterised BCR, COG1649
TW87_RS17070	COG0438	transferase activity, transferring glycosyl groups
TW87_RS17075	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
TW87_RS17080	COG1215	transferase activity, transferring glycosyl groups
TW87_RS17090	COG1215	transferase activity, transferring glycosyl groups
TW87_RS17095	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
TW87_RS17095	COG1215	transferase activity, transferring glycosyl groups
TW87_RS17100	COG1216	Glycosyl transferase, family 2
TW87_RS17120	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TW87_RS17125	COG0728	peptidoglycan biosynthetic process
TW87_RS17130	COG0860	N-Acetylmuramoyl-L-alanine amidase
TW87_RS17130	COG2247	cell wall binding repeat
TW87_RS17135	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
TW87_RS17140	COG0860	N-Acetylmuramoyl-L-alanine amidase
TW87_RS17150	COG2247	cell wall binding repeat
TW87_RS17150	COG0860	N-Acetylmuramoyl-L-alanine amidase
TW87_RS17160	COG2246	polysaccharide biosynthetic process
TW87_RS17165	COG2247	cell wall binding repeat
TW87_RS17165	COG0860	N-Acetylmuramoyl-L-alanine amidase
TW87_RS17180	COG0653	protein targeting
TW87_RS17215	COG2247	cell wall binding repeat
TW87_RS17215	COG0860	N-Acetylmuramoyl-L-alanine amidase
TW87_RS17235	COG0343	queuine tRNA-ribosyltransferase activity
TW87_RS17245	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
TW87_RS17250	COG2255	four-way junction helicase activity
TW87_RS17255	COG0632	four-way junction helicase activity
TW87_RS17260	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TW87_RS17285	COG2610	gluconate transmembrane transporter activity
TW87_RS17290	COG2084	Dehydrogenase
TW87_RS17310	COG1132	(ABC) transporter
TW87_RS17330	COG0700	Nucleoside recognition
TW87_RS17335	COG3366	ferrous iron transmembrane transporter activity
TW87_RS17340	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TW87_RS17360	COG1902	pentaerythritol trinitrate reductase activity
TW87_RS17370	COG0436	Aminotransferase
TW87_RS17375	COG0697	spore germination
TW87_RS17390	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
TW87_RS17405	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TW87_RS17410	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
TW87_RS17415	COG1473	amidohydrolase
TW87_RS17420	COG3949	Membrane
TW87_RS17435	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TW87_RS17450	COG0604	alcohol dehydrogenase
TW87_RS17460	COG1592	Rubrerythrin
TW87_RS17465	COG0789	Transcriptional regulator
TW87_RS17475	COG1664	Polymer-forming cytoskeletal
TW87_RS17480	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TW87_RS17480	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
TW87_RS17485	COG1349	DNA-binding transcription factor activity
TW87_RS17490	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TW87_RS17495	COG1696	Membrane protein involved in D-alanine export
TW87_RS17500	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
TW87_RS17510	COG0673	inositol 2-dehydrogenase activity
TW87_RS17520	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TW87_RS17525	COG1253	flavin adenine dinucleotide binding
TW87_RS17530	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
TW87_RS17550	COG3290	protein histidine kinase activity
TW87_RS17550	COG3829	transcription factor binding
TW87_RS17555	COG2267	carboxylic ester hydrolase activity
TW87_RS17565	COG0312	modulator of DNA gyrase
TW87_RS17570	COG0312	modulator of DNA gyrase
TW87_RS17595	COG2721	sulfolactate sulfo-lyase activity
TW87_RS17610	COG1120	ATPase activity
TW87_RS17615	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TW87_RS17620	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TW87_RS17635	COG1447	Phosphotransferase system cellobiose-specific component IIA
TW87_RS17640	COG3394	polysaccharide catabolic process
TW87_RS17645	COG1486	melibiose metabolic process
TW87_RS17650	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
TW87_RS17660	COG2188	Transcriptional regulator
TW87_RS17665	COG0534	Mate efflux family protein
TW87_RS17670	COG2199	diguanylate cyclase activity
TW87_RS17675	COG1178	ABC-type Fe3 transport system permease component
TW87_RS17680	COG3842	ATPase activity
TW87_RS17685	COG1840	ABC-type Fe3 transport system, periplasmic component
TW87_RS17690	COG1394	ATPase activity, coupled to movement of substances
TW87_RS17695	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
TW87_RS17700	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
TW87_RS17715	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
TW87_RS17720	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TW87_RS17725	COG1269	ATP hydrolysis coupled proton transport
TW87_RS17750	COG5001	Diguanylate cyclase
TW87_RS17750	COG3300	MHYT domain
TW87_RS17755	COG1012	belongs to the aldehyde dehydrogenase family
TW87_RS17755	COG1454	alcohol dehydrogenase
TW87_RS17765	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TW87_RS17775	COG0318	PFAM AMP-dependent synthetase and ligase
TW87_RS17780	COG0183	Belongs to the thiolase family
TW87_RS17785	COG1268	BioY protein
TW87_RS17800	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TW87_RS17815	COG1203	CRISPR-associated helicase, Cas3
TW87_RS17845	COG0577	efflux transmembrane transporter activity
TW87_RS17850	COG1136	(ABC) transporter
TW87_RS17855	COG1968	undecaprenyl-diphosphatase activity
TW87_RS17865	COG0745	RESPONSE REGULATOR receiver
TW87_RS17880	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TW87_RS17895	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TW87_RS17900	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TW87_RS17910	COG1120	ATPase activity
TW87_RS17915	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TW87_RS17925	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TW87_RS17930	COG0179	Fumarylacetoacetate (FAA) hydrolase
TW87_RS17955	COG1454	alcohol dehydrogenase
TW87_RS17960	COG1376	ErfK ybiS ycfS ynhG family protein
TW87_RS17970	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TW87_RS17975	COG0785	Cytochrome C biogenesis protein
TW87_RS17980	COG1733	regulation of RNA biosynthetic process
TW87_RS17985	COG0383	alpha-mannosidase activity
TW87_RS17990	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TW87_RS17995	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TW87_RS18000	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TW87_RS18000	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TW87_RS18000	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TW87_RS18005	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TW87_RS18005	COG3711	transcriptional antiterminator
TW87_RS18010	COG4975	Glucose uptake
TW87_RS18045	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
TW87_RS18060	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
TW87_RS18060	COG0517	IMP dehydrogenase activity
TW87_RS18065	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
TW87_RS18070	COG1263	PTS System
TW87_RS18070	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TW87_RS18075	COG3711	transcriptional antiterminator
TW87_RS18080	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TW87_RS18085	COG3118	belongs to the thioredoxin family
TW87_RS18095	COG0384	phenazine biosynthesis protein PhzF
TW87_RS18115	COG0542	response to heat
TW87_RS18125	COG2267	carboxylic ester hydrolase activity
TW87_RS18140	COG1737	Transcriptional regulator
TW87_RS18145	COG2971	BadF BadG BcrA BcrD
TW87_RS18150	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
TW87_RS18160	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
TW87_RS18175	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
TW87_RS18180	COG0642	Histidine kinase
TW87_RS18195	COG1136	(ABC) transporter
TW87_RS18205	COG2190	(PTS) system
TW87_RS18220	COG1263	PTS System
TW87_RS18220	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TW87_RS18235	COG2115	Belongs to the xylose isomerase family
TW87_RS18240	COG1070	Carbohydrate kinase
TW87_RS18255	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TW87_RS18255	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
TW87_RS18260	COG3716	PTS system mannose fructose sorbose family IID component
TW87_RS18290	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
TW87_RS18315	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
TW87_RS18320	COG0191	fructose-bisphosphate aldolase activity
TW87_RS18325	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TW87_RS18325	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TW87_RS18325	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TW87_RS18340	COG2723	6-phospho-beta-galactosidase activity
TW87_RS18350	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
TW87_RS18360	COG2213	PTS system mannitol-specific
TW87_RS18360	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
TW87_RS18365	COG1929	Belongs to the glycerate kinase type-1 family
TW87_RS18370	COG0383	alpha-mannosidase activity
TW87_RS18375	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TW87_RS18375	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TW87_RS18375	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TW87_RS18385	COG3394	polysaccharide catabolic process
TW87_RS18390	COG2190	(PTS) system
TW87_RS18390	COG1263	PTS System
TW87_RS18390	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TW87_RS18395	COG2188	Transcriptional regulator
TW87_RS18400	COG0366	Alpha amylase catalytic
TW87_RS18410	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
TW87_RS18425	COG2723	6-phospho-beta-galactosidase activity
TW87_RS18430	COG2190	(PTS) system
TW87_RS18430	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TW87_RS18430	COG1263	PTS System
TW87_RS18435	COG3711	transcriptional antiterminator
TW87_RS18445	COG1288	antiporter activity
TW87_RS18450	COG1263	PTS System
TW87_RS18450	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TW87_RS18455	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TW87_RS18465	COG0561	phosphatase activity
TW87_RS18470	COG1454	alcohol dehydrogenase
TW87_RS18475	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TW87_RS18480	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TW87_RS18480	COG3711	transcriptional antiterminator
TW87_RS18485	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
TW87_RS18490	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TW87_RS18495	COG0205	6-phosphofructokinase activity
TW87_RS18505	COG1473	amidohydrolase
TW87_RS18510	COG1473	amidohydrolase
TW87_RS18520	COG2723	6-phospho-beta-galactosidase activity
TW87_RS18525	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TW87_RS18525	COG1263	PTS System
TW87_RS18525	COG2190	(PTS) system
TW87_RS18540	COG1819	glycosyl
TW87_RS18545	COG3620	sequence-specific DNA binding
TW87_RS18560	COG0640	Transcriptional regulator
TW87_RS18570	COG2723	6-phospho-beta-galactosidase activity
TW87_RS18575	COG1263	PTS System
TW87_RS18575	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TW87_RS18575	COG2190	(PTS) system
TW87_RS18580	COG3711	transcriptional antiterminator
TW87_RS18585	COG1263	PTS System
TW87_RS18585	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TW87_RS18590	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TW87_RS18600	COG2723	6-phospho-beta-galactosidase activity
TW87_RS18610	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TW87_RS18610	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TW87_RS18610	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TW87_RS18615	COG3711	transcriptional antiterminator
TW87_RS18620	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TW87_RS18620	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TW87_RS18620	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TW87_RS18625	COG0191	fructose-bisphosphate aldolase activity
TW87_RS18630	COG2723	6-phospho-beta-galactosidase activity
TW87_RS18635	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TW87_RS18635	COG1263	PTS System
TW87_RS18635	COG2190	(PTS) system
TW87_RS18640	COG3711	transcriptional antiterminator
TW87_RS18660	COG0693	protein deglycase activity
TW87_RS18675	COG4509	Sortase family
TW87_RS18715	COG3620	sequence-specific DNA binding
TW87_RS18735	COG0582	viral genome integration into host DNA
TW87_RS18795	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TW87_RS18855	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TW87_RS18880	COG1131	(ABC) transporter
TW87_RS18890	COG0557	exoribonuclease II activity
TW87_RS18905	COG1881	PFAM PEBP family protein
TW87_RS18930	COG0148	phosphopyruvate hydratase activity
TW87_RS18935	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
TW87_RS18940	COG0149	triose-phosphate isomerase activity
TW87_RS18945	COG0126	phosphoglycerate kinase activity
TW87_RS18955	COG2390	Transcriptional regulator
TW87_RS18960	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
TW87_RS18965	COG1529	Aldehyde oxidase and xanthine dehydrogenase
TW87_RS18975	COG0167	dihydroorotate dehydrogenase activity
TW87_RS18985	COG0402	S-adenosylhomocysteine deaminase activity
TW87_RS18990	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
TW87_RS19010	COG3829	transcription factor binding
TW87_RS19015	COG0251	oxidation-reduction process
TW87_RS19030	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
TW87_RS19035	COG0789	Transcriptional regulator
TW87_RS19045	COG2247	cell wall binding repeat
TW87_RS19045	COG0860	N-Acetylmuramoyl-L-alanine amidase
TW87_RS19055	COG2207	Transcriptional regulator
TW87_RS19060	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TW87_RS19070	COG0789	Transcriptional regulator
TW87_RS19095	COG2770	Histidine kinase
TW87_RS19095	COG2205	protein histidine kinase activity
TW87_RS19100	COG0745	RESPONSE REGULATOR receiver
TW87_RS19105	COG0706	membrane insertase activity
TW87_RS19115	COG0778	Nitroreductase
TW87_RS19125	COG0534	Mate efflux family protein
TW87_RS19145	COG2226	methyltransferase
TW87_RS19165	COG1732	Glycine betaine
TW87_RS19170	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate