locus-tag	class	description
C3V37_RS00015	COG1309	transcriptional regulator
C3V37_RS00020	COG1132	(ABC) transporter
C3V37_RS00025	COG1132	(ABC) transporter
C3V37_RS00030	COG1129	ABC transporter
C3V37_RS00045	COG2176	DNA-directed DNA polymerase activity
C3V37_RS00050	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C3V37_RS00055	COG1739	Uncharacterized protein family UPF0029
C3V37_RS00060	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C3V37_RS00065	COG0217	transcriptional regulatory protein
C3V37_RS00085	COG0601	transmembrane transport
C3V37_RS00095	COG0444	Belongs to the ABC transporter superfamily
C3V37_RS00100	COG4608	Belongs to the ABC transporter superfamily
C3V37_RS00120	COG0210	DNA helicase
C3V37_RS00130	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C3V37_RS00135	COG1494	fructose-1,6-bisphosphatase
C3V37_RS00140	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C3V37_RS00145	COG0779	Required for maturation of 30S ribosomal subunits
C3V37_RS00150	COG0195	Participates in both transcription termination and antitermination
C3V37_RS00160	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C3V37_RS00165	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C3V37_RS00170	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C3V37_RS00180	COG0196	riboflavin kinase activity
C3V37_RS00185	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C3V37_RS00190	COG1185	polyribonucleotide nucleotidyltransferase activity
C3V37_RS00195	COG0756	dUTP diphosphatase activity
C3V37_RS00200	COG1968	undecaprenyl-diphosphatase activity
C3V37_RS00220	COG1058	Belongs to the CinA family
C3V37_RS00220	COG1546	Belongs to the CinA family
C3V37_RS00225	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C3V37_RS00235	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C3V37_RS00255	COG4412	M6 family metalloprotease domain protein
C3V37_RS00255	COG1404	Belongs to the peptidase S8 family
C3V37_RS00260	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C3V37_RS00265	COG0268	Binds directly to 16S ribosomal RNA
C3V37_RS00275	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C3V37_RS00275	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C3V37_RS00280	COG0237	dephospho-CoA kinase activity
C3V37_RS00285	COG0741	lytic transglycosylase activity
C3V37_RS00295	COG4656	Part of a membrane complex involved in electron transport
C3V37_RS00300	COG4658	electron transport chain
C3V37_RS00305	COG4659	FMN binding
C3V37_RS00315	COG4657	Part of a membrane complex involved in electron transport
C3V37_RS00320	COG2878	Part of a membrane complex involved in electron transport
C3V37_RS00320	COG1245	4Fe-4S binding domain
C3V37_RS00350	COG0768	penicillin binding
C3V37_RS00390	COG0205	6-phosphofructokinase activity
C3V37_RS00395	COG0469	pyruvate kinase activity
C3V37_RS00400	COG2131	deaminase
C3V37_RS00405	COG1970	mechanosensitive ion channel activity
C3V37_RS00415	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C3V37_RS00420	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C3V37_RS00425	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C3V37_RS00430	COG0509	glycine decarboxylation via glycine cleavage system
C3V37_RS00435	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C3V37_RS00440	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C3V37_RS00450	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C3V37_RS00460	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C3V37_RS00475	COG1362	aminopeptidase activity
C3V37_RS00490	COG2996	Protein conserved in bacteria
C3V37_RS00500	COG1131	(ABC) transporter
C3V37_RS00515	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C3V37_RS00520	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C3V37_RS00525	COG0193	aminoacyl-tRNA hydrolase activity
C3V37_RS00530	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C3V37_RS00535	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C3V37_RS00540	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C3V37_RS00545	COG0772	Belongs to the SEDS family
C3V37_RS00550	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C3V37_RS00555	COG0156	8-amino-7-oxononanoate synthase activity
C3V37_RS00565	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C3V37_RS00570	COG2720	vancomycin resistance protein
C3V37_RS00575	COG0561	phosphatase activity
C3V37_RS00585	COG1283	sodium-dependent phosphate transmembrane transporter activity
C3V37_RS00595	COG3118	belongs to the thioredoxin family
C3V37_RS00640	COG0284	orotidine-5'-phosphate decarboxylase activity
C3V37_RS00645	COG0543	2 iron, 2 sulfur cluster binding
C3V37_RS00650	COG0167	dihydroorotate dehydrogenase activity
C3V37_RS00655	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C3V37_RS00655	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C3V37_RS00665	COG2337	Toxic component of a toxin-antitoxin (TA) module
C3V37_RS00670	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
C3V37_RS00700	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
C3V37_RS00730	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C3V37_RS00735	COG2884	Cell division ATP-binding protein ftsE
C3V37_RS00740	COG2177	Part of the ABC transporter FtsEX involved in
C3V37_RS00745	COG0741	lytic transglycosylase activity
C3V37_RS00745	COG0739	heme binding
C3V37_RS00745	COG1196	nuclear chromosome segregation
C3V37_RS00765	COG0556	nucleotide-excision repair
C3V37_RS00780	COG1704	LemA family
C3V37_RS00785	COG0544	peptidyl-prolyl cis-trans isomerase activity
C3V37_RS00790	COG0740	serine-type endopeptidase activity
C3V37_RS00795	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C3V37_RS00805	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C3V37_RS00810	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C3V37_RS00825	COG1217	gtp-binding protein TYPA
C3V37_RS00830	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C3V37_RS00835	COG1418	mRNA catabolic process
C3V37_RS00840	COG4974	Belongs to the 'phage' integrase family
C3V37_RS00845	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
C3V37_RS00850	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C3V37_RS00855	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C3V37_RS00860	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C3V37_RS00865	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C3V37_RS00870	COG0539	negative regulation of cytoplasmic translation
C3V37_RS00875	COG0539	negative regulation of cytoplasmic translation
C3V37_RS00875	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C3V37_RS00885	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C3V37_RS00890	COG2081	HI0933 family
C3V37_RS00905	COG1187	pseudouridine synthase activity
C3V37_RS00910	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C3V37_RS00920	COG1994	Peptidase M50
C3V37_RS00930	COG0494	nUDIX hydrolase
C3V37_RS00935	COG0497	DNA recombination
C3V37_RS00950	COG2176	DNA-directed DNA polymerase activity
C3V37_RS00960	COG0750	zinc metalloprotease
C3V37_RS00965	COG4589	Belongs to the CDS family
C3V37_RS00970	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C3V37_RS00975	COG0233	cytoplasmic translational termination
C3V37_RS00980	COG0528	UMP kinase activity
C3V37_RS00985	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C3V37_RS00990	COG0052	Belongs to the universal ribosomal protein uS2 family
C3V37_RS01020	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
C3V37_RS01020	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
C3V37_RS01045	COG3142	Participates in the control of copper homeostasis
C3V37_RS01060	COG0116	Belongs to the methyltransferase superfamily
C3V37_RS01065	COG2033	superoxide reductase activity
C3V37_RS01075	COG1785	Belongs to the alkaline phosphatase family
C3V37_RS01095	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C3V37_RS01100	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C3V37_RS01105	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C3V37_RS01110	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C3V37_RS01120	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C3V37_RS01150	COG1136	(ABC) transporter
C3V37_RS01155	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C3V37_RS01155	COG0493	'glutamate synthase
C3V37_RS01170	COG1114	Component of the transport system for branched-chain amino acids
C3V37_RS01175	COG0459	protein refolding
C3V37_RS01180	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C3V37_RS01190	COG1668	transmembrane transport
C3V37_RS01195	COG4152	abc transporter atp-binding protein
C3V37_RS01200	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
C3V37_RS01205	COG0488	(ABC) transporter
C3V37_RS01210	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C3V37_RS01215	COG0390	transport system, permease component
C3V37_RS01245	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C3V37_RS01250	COG0433	COG0433 Predicted ATPase
C3V37_RS01255	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C3V37_RS01265	COG2081	HI0933 family
C3V37_RS01275	COG2233	PERMEase
C3V37_RS01280	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C3V37_RS01285	COG2890	protein-(glutamine-N5) methyltransferase activity
C3V37_RS01290	COG3872	metal-dependent enzyme
C3V37_RS01295	COG0254	rRNA binding
C3V37_RS01305	COG0142	geranyltranstransferase activity
C3V37_RS01320	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C3V37_RS01335	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C3V37_RS01390	COG0826	peptidase U32
C3V37_RS01395	COG4122	O-methyltransferase activity
C3V37_RS01400	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C3V37_RS01415	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C3V37_RS01430	COG0358	DNA primase activity
C3V37_RS01435	COG0358	DNA primase activity
C3V37_RS01440	COG0232	Belongs to the dGTPase family. Type 2 subfamily
C3V37_RS01450	COG0752	glycyl-tRNA synthetase alpha subunit
C3V37_RS01460	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C3V37_RS01465	COG0295	cytidine deaminase activity
C3V37_RS01470	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C3V37_RS01475	COG1702	phosphate starvation-inducible protein PhoH
C3V37_RS01485	COG4864	UPF0365 protein
C3V37_RS01495	COG1862	Preprotein translocase
C3V37_RS01500	COG0343	queuine tRNA-ribosyltransferase activity
C3V37_RS01505	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C3V37_RS01510	COG2385	sporulation resulting in formation of a cellular spore
C3V37_RS01515	COG2255	four-way junction helicase activity
C3V37_RS01520	COG0632	four-way junction helicase activity
C3V37_RS01525	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C3V37_RS01540	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
C3V37_RS01545	COG2195	Cleaves the N-terminal amino acid of tripeptides
C3V37_RS01550	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C3V37_RS01555	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C3V37_RS01555	COG0574	Belongs to the PEP-utilizing enzyme family
C3V37_RS01560	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
C3V37_RS01565	COG0151	Belongs to the GarS family
C3V37_RS01575	COG2321	neutral zinc metallopeptidase
C3V37_RS01595	COG0363	glucosamine-6-phosphate deaminase activity
C3V37_RS01605	COG4717	serine-type aminopeptidase activity
C3V37_RS01645	COG4496	protein, YerC YecD
C3V37_RS01650	COG2759	Belongs to the formate--tetrahydrofolate ligase family
C3V37_RS01655	COG2252	PERMEase
C3V37_RS01660	COG0138	bifunctional purine biosynthesis protein purh
C3V37_RS01665	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C3V37_RS01670	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C3V37_RS01675	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C3V37_RS01715	COG0525	valine-tRNA ligase activity
C3V37_RS01720	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
C3V37_RS01735	COG4472	Bacterial protein of unknown function (DUF965)
C3V37_RS01740	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C3V37_RS01745	COG0628	permease
C3V37_RS01750	COG0822	iron-sulfur transferase activity
C3V37_RS01760	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C3V37_RS01765	COG0251	oxidation-reduction process
C3V37_RS01775	COG1418	mRNA catabolic process
C3V37_RS01780	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C3V37_RS01790	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C3V37_RS01805	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C3V37_RS01810	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C3V37_RS01815	COG0758	DNA mediated transformation
C3V37_RS01820	COG0606	chelatase, subunit chli
C3V37_RS01825	COG0792	nuclease activity
C3V37_RS01830	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C3V37_RS01835	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
C3V37_RS01845	COG0336	Belongs to the RNA methyltransferase TrmD family
C3V37_RS01850	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C3V37_RS01860	COG0228	four-way junction DNA binding
C3V37_RS01865	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C3V37_RS01870	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
C3V37_RS01875	COG0552	protein localization to endoplasmic reticulum
C3V37_RS01880	COG1196	nuclear chromosome segregation
C3V37_RS01890	COG0571	ribonuclease III activity
C3V37_RS01895	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C3V37_RS01900	COG0416	fatty acid biosynthetic process
C3V37_RS01940	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C3V37_RS01945	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C3V37_RS01950	COG1323	Belongs to the UPF0348 family
C3V37_RS01965	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C3V37_RS01970	COG0742	ribosomal rna small subunit methyltransferase
C3V37_RS01975	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C3V37_RS01980	COG1461	Dihydroxyacetone kinase
C3V37_RS01990	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C3V37_RS02000	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C3V37_RS02005	COG1162	GTPase activity
C3V37_RS02010	COG2815	serine threonine protein kinase
C3V37_RS02010	COG0515	serine threonine protein kinase
C3V37_RS02015	COG0631	protein serine/threonine phosphatase activity
C3V37_RS02020	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C3V37_RS02025	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C3V37_RS02025	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C3V37_RS02030	COG2738	Putative neutral zinc metallopeptidase
C3V37_RS02035	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C3V37_RS02040	COG0242	peptide deformylase activity
C3V37_RS02045	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C3V37_RS02050	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C3V37_RS02055	COG1758	RNA polymerase activity
C3V37_RS02065	COG2052	Domain of unknown function (DUF370)
C3V37_RS02070	COG1561	YicC-like family, N-terminal region
C3V37_RS02080	COG0564	pseudouridine synthase activity
C3V37_RS02085	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C3V37_RS02095	COG1799	cell septum assembly
C3V37_RS02100	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C3V37_RS02110	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C3V37_RS02115	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C3V37_RS02120	COG1160	GTP binding
C3V37_RS02125	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C3V37_RS02135	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C3V37_RS02140	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C3V37_RS02145	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C3V37_RS02150	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C3V37_RS02155	COG1490	D-aminoacyl-tRNA deacylase activity
C3V37_RS02160	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C3V37_RS02165	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C3V37_RS02165	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
C3V37_RS02170	COG1129	ABC transporter
C3V37_RS02190	COG1132	(ABC) transporter
C3V37_RS02195	COG1132	(ABC) transporter
C3V37_RS02205	COG0791	NLP P60 protein
C3V37_RS02210	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C3V37_RS02265	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
C3V37_RS02295	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C3V37_RS02305	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
C3V37_RS02345	COG5002	protein histidine kinase activity
C3V37_RS02350	COG0745	RESPONSE REGULATOR receiver
C3V37_RS02365	COG0495	leucyl-tRNA aminoacylation
C3V37_RS02370	COG0017	Asparaginyl-tRNA synthetase
C3V37_RS02385	COG0534	Mate efflux family protein
C3V37_RS02390	COG0024	Methionine aminopeptidase
C3V37_RS02395	COG2217	Heavy metal translocating P-type atpase
C3V37_RS02400	COG1136	(ABC) transporter
C3V37_RS02410	COG0577	efflux transmembrane transporter activity
C3V37_RS02420	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C3V37_RS02425	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C3V37_RS02435	COG5505	Protein of unknown function (DUF819)
C3V37_RS02440	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C3V37_RS02445	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
C3V37_RS02450	COG0037	tRNA processing
C3V37_RS02455	COG1185	polyribonucleotide nucleotidyltransferase activity
C3V37_RS02465	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C3V37_RS02470	COG0776	regulation of translation
C3V37_RS02475	COG2244	polysaccharide biosynthetic process
C3V37_RS02480	COG0745	RESPONSE REGULATOR receiver
C3V37_RS02520	COG0482	sulfurtransferase activity
C3V37_RS02525	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C3V37_RS02530	COG0617	tRNA 3'-terminal CCA addition
C3V37_RS02550	COG1924	4 iron, 4 sulfur cluster binding
C3V37_RS02560	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
C3V37_RS02570	COG1051	belongs to the nudix hydrolase family
C3V37_RS02695	COG0018	arginyl-trna synthetase
C3V37_RS02700	COG1193	negative regulation of DNA recombination
C3V37_RS02705	COG0826	peptidase U32
C3V37_RS02720	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C3V37_RS02725	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C3V37_RS02730	COG0569	domain protein
C3V37_RS02735	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C3V37_RS02740	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C3V37_RS02745	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C3V37_RS02765	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
C3V37_RS02770	COG1164	Oligoendopeptidase f
C3V37_RS02785	COG1716	ATPase activity
C3V37_RS02795	COG2827	Endonuclease containing a URI domain
C3V37_RS02810	COG5002	protein histidine kinase activity
C3V37_RS02820	COG1074	ATP-dependent DNA helicase activity
C3V37_RS02865	COG0280	phosphate acetyltransferase
C3V37_RS02870	COG2059	Chromate
C3V37_RS02875	COG2059	Chromate
C3V37_RS02885	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C3V37_RS02905	COG0305	Participates in initiation and elongation during chromosome replication
C3V37_RS02910	COG0359	binds to the 23S rRNA
C3V37_RS02925	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C3V37_RS02935	COG0312	modulator of DNA gyrase
C3V37_RS02985	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C3V37_RS02990	COG1040	competence protein
C3V37_RS02995	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
C3V37_RS03010	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C3V37_RS03015	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C3V37_RS03020	COG0101	tRNA pseudouridine synthase activity
C3V37_RS03025	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
C3V37_RS03030	COG1122	ATPase activity
C3V37_RS03035	COG1122	ATPase activity
C3V37_RS03040	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C3V37_RS03050	COG0628	permease
C3V37_RS03065	COG2195	Cleaves the N-terminal amino acid of tripeptides
C3V37_RS03080	COG0012	GTP binding
C3V37_RS03085	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
C3V37_RS03090	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C3V37_RS03095	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C3V37_RS03100	COG0698	ribose 5-phosphate isomerase
C3V37_RS03105	COG0009	L-threonylcarbamoyladenylate synthase
C3V37_RS03110	COG1361	Conserved repeat domain
C3V37_RS03125	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C3V37_RS03130	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C3V37_RS03140	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C3V37_RS03150	COG0577	efflux transmembrane transporter activity
C3V37_RS03150	COG1136	(ABC) transporter
C3V37_RS03165	COG1136	(ABC) transporter
C3V37_RS03185	COG3470	protein probably involved in high-affinity Fe2 transport
C3V37_RS03190	COG0672	)-iron permease
C3V37_RS03195	COG3639	organic phosphonate transmembrane transporter activity
C3V37_RS03215	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C3V37_RS03225	COG1464	Belongs to the NlpA lipoprotein family
C3V37_RS03230	COG2011	ABC-type metal ion transport system permease component
C3V37_RS03275	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C3V37_RS03280	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C3V37_RS03315	COG1307	EDD domain protein, DegV family
C3V37_RS03325	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
C3V37_RS03330	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
C3V37_RS03335	COG1160	GTP binding
C3V37_RS03340	COG0747	negative chemotaxis
C3V37_RS03345	COG1073	alpha beta
C3V37_RS03350	COG0739	heme binding
C3V37_RS03365	COG0590	tRNA wobble adenosine to inosine editing
C3V37_RS03370	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
C3V37_RS03370	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
C3V37_RS03480	COG1979	alcohol dehydrogenase
C3V37_RS03485	COG1316	TRANSCRIPTIONal
C3V37_RS03495	COG0406	alpha-ribazole phosphatase activity
C3V37_RS03500	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
C3V37_RS03505	COG0517	IMP dehydrogenase activity
C3V37_RS03505	COG0516	GMP reductase activity
C3V37_RS03515	COG4475	Protein of unknown function (DUF436)
C3V37_RS03525	COG4509	Sortase family
C3V37_RS03550	COG0535	radical SAM domain protein
C3V37_RS03565	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C3V37_RS03570	COG1592	Rubrerythrin
C3V37_RS03615	COG1309	transcriptional regulator
C3V37_RS03620	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C3V37_RS03620	COG3153	acetyltransferase
C3V37_RS03625	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
C3V37_RS03665	COG1121	(ABC) transporter
C3V37_RS03670	COG1744	ABC transporter substrate-binding protein PnrA-like
C3V37_RS03675	COG2153	protein acetylation
C3V37_RS03680	COG0475	glutathione-regulated potassium exporter activity
C3V37_RS03690	COG3048	D-serine ammonia-lyase activity
C3V37_RS03710	COG0328	RNA-DNA hybrid ribonuclease activity
C3V37_RS03715	COG0113	porphobilinogen synthase activity
C3V37_RS03725	COG0181	hydroxymethylbilane synthase activity
C3V37_RS03735	COG1122	ATPase activity
C3V37_RS03745	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
C3V37_RS03750	COG0310	cobalt ion transport
C3V37_RS03765	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C3V37_RS03775	COG0084	hydrolase, TatD family'
C3V37_RS03780	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C3V37_RS03780	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C3V37_RS03795	COG2226	methyltransferase
C3V37_RS03800	COG2373	Large extracellular alpha-helical protein
C3V37_RS03815	COG1027	Aspartate ammonia-lyase
C3V37_RS03820	COG0297	glycogen (starch) synthase activity
C3V37_RS03835	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C3V37_RS03875	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C3V37_RS03895	COG0203	ribosomal protein L17
C3V37_RS03905	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C3V37_RS03910	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C3V37_RS03920	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C3V37_RS03930	COG0563	adenylate kinase activity
C3V37_RS03935	COG0201	protein transport
C3V37_RS03940	COG0200	Binds to the 23S rRNA
C3V37_RS03945	COG1841	ribosomal large subunit assembly
C3V37_RS03950	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C3V37_RS03955	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C3V37_RS03960	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C3V37_RS03965	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C3V37_RS03970	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C3V37_RS03975	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C3V37_RS03980	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C3V37_RS03985	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C3V37_RS03990	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C3V37_RS03995	COG0255	Belongs to the universal ribosomal protein uL29 family
C3V37_RS04000	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C3V37_RS04005	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C3V37_RS04010	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C3V37_RS04015	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C3V37_RS04025	COG0089	rRNA binding
C3V37_RS04030	COG0088	Forms part of the polypeptide exit tunnel
C3V37_RS04035	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C3V37_RS04040	COG0051	transcription antitermination factor activity, RNA binding
C3V37_RS04095	COG1131	(ABC) transporter
C3V37_RS04110	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C3V37_RS04120	COG0360	Binds together with S18 to 16S ribosomal RNA
C3V37_RS04130	COG0602	queuosine metabolic process
C3V37_RS04135	COG1328	CTP reductase activity
C3V37_RS04135	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C3V37_RS04170	COG0431	NADPH-dependent FMN reductase
C3V37_RS04175	COG0285	dihydrofolate synthase activity
C3V37_RS04180	COG0745	RESPONSE REGULATOR receiver
C3V37_RS04205	COG1129	ABC transporter
C3V37_RS04210	COG1609	Transcriptional regulator
C3V37_RS04215	COG0386	Belongs to the glutathione peroxidase family
C3V37_RS04230	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C3V37_RS04240	COG1960	acyl-CoA dehydrogenase activity
C3V37_RS04270	COG1131	(ABC) transporter
C3V37_RS04280	COG2801	Transposase and inactivated derivatives
C3V37_RS04355	COG0726	polysaccharide deacetylase
C3V37_RS04360	COG1696	Membrane protein involved in D-alanine export
C3V37_RS04380	COG1151	hydroxylamine reductase activity
C3V37_RS04405	COG1131	(ABC) transporter
C3V37_RS04420	COG3579	cysteine-type endopeptidase activity
C3V37_RS04440	COG1918	ferrous iron import across plasma membrane
C3V37_RS04440	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
C3V37_RS04475	COG2205	protein histidine kinase activity
C3V37_RS04480	COG0745	RESPONSE REGULATOR receiver
C3V37_RS04485	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
C3V37_RS04490	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
C3V37_RS04495	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
C3V37_RS04510	COG2205	protein histidine kinase activity
C3V37_RS04525	COG1598	PFAM Uncharacterised protein family UPF0150
C3V37_RS04550	COG1132	(ABC) transporter
C3V37_RS04555	COG1132	(ABC) transporter
C3V37_RS04560	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C3V37_RS04565	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C3V37_RS04570	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C3V37_RS04600	COG1696	Membrane protein involved in D-alanine export
C3V37_RS04605	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C3V37_RS04625	COG0745	RESPONSE REGULATOR receiver
C3V37_RS04630	COG2205	protein histidine kinase activity
C3V37_RS04635	COG0577	efflux transmembrane transporter activity
C3V37_RS04635	COG1136	(ABC) transporter
C3V37_RS04645	COG3620	sequence-specific DNA binding
C3V37_RS04650	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
C3V37_RS04660	COG1346	cytolysis
C3V37_RS04665	COG1307	EDD domain protein, DegV family
C3V37_RS04670	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C3V37_RS04685	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C3V37_RS04690	COG1120	ATPase activity
C3V37_RS04705	COG3266	domain, Protein
C3V37_RS04705	COG1361	Conserved repeat domain
C3V37_RS04705	COG2911	Protein conserved in bacteria
C3V37_RS04710	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C3V37_RS04715	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C3V37_RS04735	COG5002	protein histidine kinase activity
C3V37_RS04740	COG0745	RESPONSE REGULATOR receiver
C3V37_RS04745	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C3V37_RS04780	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C3V37_RS04785	COG0037	tRNA processing
C3V37_RS04795	COG0668	transmembrane transport
C3V37_RS04835	COG2801	Transposase and inactivated derivatives
C3V37_RS04840	COG4988	ABC transporter
C3V37_RS04845	COG1132	(ABC) transporter
C3V37_RS04870	COG0281	malic enzyme
C3V37_RS04875	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C3V37_RS04885	COG3340	Belongs to the peptidase S51 family
C3V37_RS04910	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C3V37_RS04915	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C3V37_RS04920	COG1446	asparaginase
C3V37_RS04930	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C3V37_RS04970	COG1823	symporter activity
C3V37_RS04990	COG3850	Histidine kinase
C3V37_RS04990	COG5002	protein histidine kinase activity
C3V37_RS04995	COG0745	RESPONSE REGULATOR receiver
C3V37_RS05015	COG0542	response to heat
C3V37_RS05020	COG0484	heat shock protein binding
C3V37_RS05025	COG2205	protein histidine kinase activity
C3V37_RS05050	COG1011	Hydrolase
C3V37_RS05145	COG2373	Large extracellular alpha-helical protein
C3V37_RS05150	COG3404	Formiminotransferase-cyclodeaminase
C3V37_RS05155	COG0384	phenazine biosynthesis protein PhzF
C3V37_RS05160	COG1475	DNA binding
C3V37_RS05165	COG1192	Involved in chromosome partitioning
C3V37_RS05170	COG0357	Ribosomal RNA small subunit methyltransferase G
C3V37_RS05175	COG1408	metallophosphoesterase
C3V37_RS05180	COG0445	tRNA wobble uridine modification
C3V37_RS05185	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C3V37_RS05195	COG0706	membrane insertase activity
C3V37_RS05200	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C3V37_RS05205	COG0594	ribonuclease P activity
C3V37_RS05210	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C3V37_RS05220	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C3V37_RS05240	COG0187	DNA topoisomerase II activity
C3V37_RS05245	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C3V37_RS05265	COG0095	Lipoate-protein ligase
C3V37_RS05270	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C3V37_RS05280	COG0601	transmembrane transport
C3V37_RS05285	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C3V37_RS05290	COG0444	Belongs to the ABC transporter superfamily
C3V37_RS05295	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C3V37_RS05300	COG0786	glutamate:sodium symporter activity
C3V37_RS05345	COG0488	(ABC) transporter
C3V37_RS05360	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C3V37_RS05360	COG1404	Belongs to the peptidase S8 family
C3V37_RS05380	COG0798	PFAM Bile acid sodium symporter
C3V37_RS05435	COG5002	protein histidine kinase activity
C3V37_RS05450	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C3V37_RS05455	COG0581	inorganic phosphate transmembrane transporter activity
C3V37_RS05460	COG0573	inorganic phosphate transmembrane transporter activity
C3V37_RS05465	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C3V37_RS05470	COG0653	protein targeting
C3V37_RS05485	COG1214	PFAM Peptidase M22, glycoprotease
C3V37_RS05525	COG2309	aminopeptidase activity
C3V37_RS05545	COG1481	regulation of sporulation
C3V37_RS05595	COG1129	ABC transporter
C3V37_RS05600	COG1132	(ABC) transporter
C3V37_RS05605	COG1132	(ABC) transporter
C3V37_RS05620	COG1309	transcriptional regulator
C3V37_RS05625	COG2375	cellular response to nickel ion
C3V37_RS05625	COG1132	(ABC) transporter
C3V37_RS05630	COG1132	(ABC) transporter
C3V37_RS05665	COG1619	proteins homologs of microcin C7 resistance protein MccF
C3V37_RS05740	COG1309	transcriptional regulator
C3V37_RS05745	COG2375	cellular response to nickel ion
C3V37_RS05745	COG1132	(ABC) transporter
C3V37_RS05750	COG1132	(ABC) transporter
C3V37_RS05765	COG1408	metallophosphoesterase
C3V37_RS05770	COG3266	domain, Protein
C3V37_RS05770	COG2911	Protein conserved in bacteria
C3V37_RS05770	COG1361	Conserved repeat domain
C3V37_RS05785	COG1121	(ABC) transporter
C3V37_RS05790	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C3V37_RS05800	COG0577	efflux transmembrane transporter activity
C3V37_RS05800	COG1136	(ABC) transporter
C3V37_RS05840	COG1115	amino acid carrier protein
C3V37_RS05845	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C3V37_RS05855	COG0534	Mate efflux family protein
C3V37_RS05880	COG1496	oxidoreductase activity
C3V37_RS05885	COG1362	aminopeptidase activity
C3V37_RS05890	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C3V37_RS05900	COG1373	ATPase (AAA superfamily
C3V37_RS05905	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C3V37_RS05905	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C3V37_RS05910	COG1846	Transcriptional regulator
C3V37_RS05920	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C3V37_RS05925	COG2235	arginine
C3V37_RS05930	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C3V37_RS05935	COG0549	Belongs to the carbamate kinase family
C3V37_RS05965	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C3V37_RS05970	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C3V37_RS05975	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C3V37_RS05980	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C3V37_RS05985	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C3V37_RS05990	COG1304	FMN binding
C3V37_RS05995	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C3V37_RS06005	COG0351	phosphomethylpyrimidine kinase
C3V37_RS06005	COG0352	thiamine-phosphate diphosphorylase activity
C3V37_RS06015	COG1361	Conserved repeat domain
C3V37_RS06035	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C3V37_RS06040	COG0823	Involved in the tonB-independent uptake of proteins
C3V37_RS06040	COG4946	Tricorn protease homolog
C3V37_RS06040	COG1506	peptidase
C3V37_RS06055	COG2860	membrane
C3V37_RS06085	COG2986	histidine ammonia-lyase
C3V37_RS06090	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C3V37_RS06095	COG1228	amidohydrolase
C3V37_RS06105	COG0747	negative chemotaxis
C3V37_RS06110	COG0601	transmembrane transport
C3V37_RS06115	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C3V37_RS06120	COG0444	Belongs to the ABC transporter superfamily
C3V37_RS06125	COG4608	Belongs to the ABC transporter superfamily
C3V37_RS06130	COG0583	DNA-binding transcription factor activity
C3V37_RS06140	COG1132	(ABC) transporter
C3V37_RS06145	COG1104	cysteine desulfurase activity
C3V37_RS06150	COG0301	tRNA thio-modification
C3V37_RS06155	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
C3V37_RS06160	COG1132	(ABC) transporter
C3V37_RS06170	COG0442	prolyl-tRNA aminoacylation
C3V37_RS06175	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C3V37_RS06200	COG1222	aaa ATPase
C3V37_RS06215	COG1393	Belongs to the ArsC family
C3V37_RS06220	COG1472	Belongs to the glycosyl hydrolase 3 family
C3V37_RS06225	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C3V37_RS06230	COG1028	Short-chain dehydrogenase reductase Sdr
C3V37_RS06260	COG0085	RNA polymerase activity
C3V37_RS06265	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C3V37_RS06270	COG1358	cellular component organization or biogenesis
C3V37_RS06275	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C3V37_RS06280	COG0049	tRNA binding
C3V37_RS06285	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C3V37_RS06290	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C3V37_RS06300	COG1473	amidohydrolase
C3V37_RS06305	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C3V37_RS06310	COG4463	regulation of RNA biosynthetic process
C3V37_RS06325	COG0542	response to heat
C3V37_RS06330	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
C3V37_RS06335	COG1329	Transcriptional regulator
C3V37_RS06340	COG4956	integral membrane protein (PIN domain superfamily)
C3V37_RS06345	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C3V37_RS06350	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C3V37_RS06355	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C3V37_RS06365	COG3266	domain, Protein
C3V37_RS06365	COG2911	Protein conserved in bacteria
C3V37_RS06365	COG1361	Conserved repeat domain
C3V37_RS06370	COG3842	ATPase activity
C3V37_RS06375	COG1175	transmembrane transport
C3V37_RS06380	COG0395	ABC-type sugar transport system, permease component
C3V37_RS06385	COG1653	transport
C3V37_RS06405	COG0398	Pfam SNARE associated Golgi protein
C3V37_RS06410	COG0398	Pfam SNARE associated Golgi protein
C3V37_RS06435	COG0450	alkyl hydroperoxide reductase
C3V37_RS06475	COG3177	Filamentation induced by cAMP protein fic
C3V37_RS06485	COG3842	ATPase activity
C3V37_RS06495	COG1840	ABC-type Fe3 transport system, periplasmic component
C3V37_RS06500	COG1956	GAF domain-containing protein
C3V37_RS06520	COG1132	(ABC) transporter
C3V37_RS06525	COG2274	protein secretion by the type I secretion system
C3V37_RS06535	COG3584	3D domain protein
C3V37_RS06535	COG1388	LysM domain
C3V37_RS06540	COG0708	Exodeoxyribonuclease III
C3V37_RS06545	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C3V37_RS06555	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C3V37_RS06565	COG1982	Orn Lys Arg decarboxylase major
C3V37_RS06570	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C3V37_RS06575	COG3870	Protein conserved in bacteria
C3V37_RS06585	COG1774	PSP1 C-terminal conserved region
C3V37_RS06595	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
C3V37_RS06615	COG4481	Protein conserved in bacteria
C3V37_RS06640	COG1640	4-alpha-glucanotransferase
C3V37_RS06645	COG4166	transmembrane transport
C3V37_RS06650	COG0601	transmembrane transport
C3V37_RS06655	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C3V37_RS06660	COG0444	Belongs to the ABC transporter superfamily
C3V37_RS06665	COG4608	Belongs to the ABC transporter superfamily
C3V37_RS06675	COG3279	Response regulator of the LytR AlgR family
C3V37_RS06695	COG0426	domain, Protein
C3V37_RS06715	COG2239	Acts as a magnesium transporter
C3V37_RS06720	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C3V37_RS06725	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C3V37_RS06735	COG3041	Addiction module toxin RelE StbE family
C3V37_RS06765	COG1309	transcriptional regulator
C3V37_RS06770	COG0574	Belongs to the PEP-utilizing enzyme family
C3V37_RS06770	COG3848	Pyruvate phosphate dikinase
C3V37_RS06815	COG4716	Myosin-crossreactive antigen
C3V37_RS06825	COG0215	cysteine-tRNA ligase activity
C3V37_RS06835	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C3V37_RS06840	COG3688	RNA-binding protein containing a PIN domain
C3V37_RS06855	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C3V37_RS06860	COG0250	Participates in transcription elongation, termination and antitermination
C3V37_RS06865	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C3V37_RS06870	COG0081	regulation of translation
C3V37_RS06875	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C3V37_RS06880	COG0222	ribosome binding
C3V37_RS06900	COG1132	(ABC) transporter
C3V37_RS06905	COG0728	peptidoglycan biosynthetic process
C3V37_RS06915	COG1288	antiporter activity
C3V37_RS06920	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C3V37_RS06925	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C3V37_RS06930	COG1660	Displays ATPase and GTPase activities
C3V37_RS06935	COG0391	Required for morphogenesis under gluconeogenic growth conditions
C3V37_RS06940	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C3V37_RS06945	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
C3V37_RS06950	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C3V37_RS06955	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C3V37_RS06970	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C3V37_RS06975	COG1363	Peptidase, m42
C3V37_RS06985	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C3V37_RS06985	COG0519	Catalyzes the synthesis of GMP from XMP
C3V37_RS06995	COG3682	Transcriptional regulator
C3V37_RS07000	COG2217	Heavy metal translocating P-type atpase
C3V37_RS07015	COG3550	peptidyl-serine autophosphorylation
C3V37_RS07060	COG0534	Mate efflux family protein
C3V37_RS07070	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C3V37_RS07090	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C3V37_RS07110	COG5012	cobalamin binding
C3V37_RS07115	COG1757	Na H antiporter
C3V37_RS07120	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
C3V37_RS07130	COG0564	pseudouridine synthase activity
C3V37_RS07135	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C3V37_RS07140	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C3V37_RS07145	COG1132	(ABC) transporter
C3V37_RS07150	COG1132	(ABC) transporter
C3V37_RS07180	COG0622	Phosphoesterase
C3V37_RS07190	COG2217	Heavy metal translocating P-type atpase
C3V37_RS07200	COG2608	mercury ion transmembrane transporter activity
C3V37_RS07205	COG1363	Peptidase, m42
C3V37_RS07210	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C3V37_RS07210	COG1263	PTS System
C3V37_RS07215	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C3V37_RS07230	COG2116	formate transmembrane transporter activity
C3V37_RS07245	COG1196	nuclear chromosome segregation
C3V37_RS07250	COG4868	Belongs to the UPF0371 family
C3V37_RS07260	COG0006	proline dipeptidase activity
C3V37_RS07265	COG0322	excinuclease ABC activity
C3V37_RS07305	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C3V37_RS07310	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C3V37_RS07385	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C3V37_RS07385	COG0551	DNA topoisomerase type I activity
C3V37_RS07440	COG2856	Zn peptidase
C3V37_RS07460	COG4974	Belongs to the 'phage' integrase family
C3V37_RS07465	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C3V37_RS07465	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C3V37_RS07485	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C3V37_RS07525	COG2333	competence protein COMEC
C3V37_RS07525	COG0658	competence protein
C3V37_RS07535	COG2001	Belongs to the MraZ family
C3V37_RS07540	COG0275	rRNA processing
C3V37_RS07550	COG0768	penicillin binding
C3V37_RS07560	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C3V37_RS07565	COG0772	Belongs to the SEDS family
C3V37_RS07570	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C3V37_RS07585	COG3879	Bacterial protein of unknown function (DUF881)
C3V37_RS07595	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C3V37_RS07600	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C3V37_RS07620	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C3V37_RS07630	COG0126	phosphoglycerate kinase activity
C3V37_RS07635	COG0149	triose-phosphate isomerase activity
C3V37_RS07645	COG0148	phosphopyruvate hydratase activity
C3V37_RS07670	COG1181	Belongs to the D-alanine--D-alanine ligase family
C3V37_RS07675	COG0557	exoribonuclease II activity
C3V37_RS07680	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C3V37_RS07690	COG0210	DNA helicase
C3V37_RS07695	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C3V37_RS07700	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C3V37_RS07720	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C3V37_RS07740	COG0481	GTPase activity
C3V37_RS07745	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C3V37_RS07750	COG1418	mRNA catabolic process
C3V37_RS07755	COG1420	regulation of RNA biosynthetic process
C3V37_RS07760	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C3V37_RS07765	COG0443	Heat shock 70 kDa protein
C3V37_RS07770	COG0484	heat shock protein binding
C3V37_RS07775	COG2264	protein methyltransferase activity
C3V37_RS07780	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C3V37_RS07785	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C3V37_RS07790	COG0537	adenosine 5'-monophosphoramidase activity
C3V37_RS07795	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C3V37_RS07800	COG1610	YqeY-like protein
C3V37_RS07815	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C3V37_RS07820	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C3V37_RS07820	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA