locus-tag	class	description
E2H98_RS00010	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E2H98_RS00015	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E2H98_RS00030	COG1742	UPF0060 membrane protein
E2H98_RS00060	COG1742	UPF0060 membrane protein
E2H98_RS00075	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E2H98_RS00080	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E2H98_RS00085	COG0798	PFAM Bile acid sodium symporter
E2H98_RS00090	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E2H98_RS00145	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E2H98_RS00150	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E2H98_RS00205	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
E2H98_RS00225	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
E2H98_RS00250	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E2H98_RS00255	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E2H98_RS00290	COG2217	Heavy metal translocating P-type atpase
E2H98_RS00305	COG2264	protein methyltransferase activity
E2H98_RS00320	COG2132	Multicopper oxidase
E2H98_RS00325	COG0745	RESPONSE REGULATOR receiver
E2H98_RS00330	COG5002	protein histidine kinase activity
E2H98_RS00420	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E2H98_RS00450	COG0577	efflux transmembrane transporter activity
E2H98_RS00450	COG1136	(ABC) transporter
E2H98_RS00470	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
E2H98_RS00475	COG1690	Belongs to the RtcB family
E2H98_RS00480	COG1741	Belongs to the pirin family
E2H98_RS00485	COG0589	response to stress
E2H98_RS00490	COG0659	secondary active sulfate transmembrane transporter activity
E2H98_RS00495	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E2H98_RS00500	COG1448	Aminotransferase
E2H98_RS00510	COG2079	MmgE PrpD family protein
E2H98_RS00530	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E2H98_RS00540	COG1760	l-serine dehydratase
E2H98_RS00560	COG0583	DNA-binding transcription factor activity
E2H98_RS00565	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
E2H98_RS00575	COG2915	High frequency lysogenization protein hflD homolog
E2H98_RS00640	COG0835	chemotaxis
E2H98_RS00650	COG1192	Involved in chromosome partitioning
E2H98_RS00655	COG1360	Flagellar Motor Protein
E2H98_RS00660	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E2H98_RS00665	COG2201	protein-glutamate methylesterase activity
E2H98_RS00670	COG0643	Histidine kinase
E2H98_RS00670	COG0784	Response regulator, receiver
E2H98_RS00670	COG2198	Histidine kinase
E2H98_RS00675	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
E2H98_RS00700	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E2H98_RS00710	COG1684	flagellar biosynthetic protein fliR
E2H98_RS00715	COG1987	bacterial-type flagellum assembly
E2H98_RS00760	COG0745	RESPONSE REGULATOR receiver
E2H98_RS00785	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E2H98_RS00795	COG1677	Flagellar hook-basal body complex protein FliE
E2H98_RS00815	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E2H98_RS00815	COG4797	methyltransferase
E2H98_RS00870	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E2H98_RS00880	COG1705	Flagellar rod assembly protein muramidase FlgJ
E2H98_RS00880	COG3951	Flagellar rod assembly protein muramidase FlgJ
E2H98_RS00885	COG1706	bacterial-type flagellum-dependent cell motility
E2H98_RS00890	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
E2H98_RS00900	COG4787	bacterial-type flagellum-dependent cell motility
E2H98_RS00905	COG1749	Flagellar hook protein flgE
E2H98_RS00910	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
E2H98_RS00915	COG1558	bacterial-type flagellum-dependent cell motility
E2H98_RS00920	COG1815	bacterial-type flagellum-dependent cell motility
E2H98_RS00925	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
E2H98_RS00930	COG0835	chemotaxis
E2H98_RS00930	COG0784	Response regulator, receiver
E2H98_RS00955	COG0308	aminopeptidase N
E2H98_RS00975	COG0022	dehydrogenase e1 component
E2H98_RS00985	COG1115	amino acid carrier protein
E2H98_RS01000	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
E2H98_RS01005	COG0251	oxidation-reduction process
E2H98_RS01015	COG2111	Na H antiporter
E2H98_RS01015	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E2H98_RS01025	COG0651	ATP synthesis coupled electron transport
E2H98_RS01030	COG0651	ATP synthesis coupled electron transport
E2H98_RS01035	COG1006	Multisubunit Na H antiporter MnhC subunit
E2H98_RS01050	COG2212	antiporter activity
E2H98_RS01055	COG1863	multisubunit Na H antiporter MnhE subunit
E2H98_RS01065	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
E2H98_RS01070	COG0339	signal peptide processing
E2H98_RS01085	COG1739	Uncharacterized protein family UPF0029
E2H98_RS01110	COG2866	Carboxypeptidase
E2H98_RS01125	COG1272	protein, Hemolysin III
E2H98_RS01135	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E2H98_RS01140	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
E2H98_RS01145	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E2H98_RS01150	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
E2H98_RS01170	COG0686	Belongs to the AlaDH PNT family
E2H98_RS01175	COG0492	ferredoxin-NADP+ reductase activity
E2H98_RS01180	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
E2H98_RS01185	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
E2H98_RS01195	COG0542	response to heat
E2H98_RS01200	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
E2H98_RS01205	COG1278	Cold shock
E2H98_RS01220	COG0314	molybdopterin synthase activity
E2H98_RS01230	COG1022	Amp-dependent synthetase and ligase
E2H98_RS01235	COG0247	lactate metabolic process
E2H98_RS01235	COG0277	FAD linked oxidase domain protein
E2H98_RS01240	COG5006	permease, DMT superfamily
E2H98_RS01260	COG2814	Major facilitator Superfamily
E2H98_RS01280	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E2H98_RS01280	COG4651	solute:proton antiporter activity
E2H98_RS01290	COG0681	Belongs to the peptidase S26 family
E2H98_RS01310	COG4783	chaperone-mediated protein folding
E2H98_RS01315	COG5001	Diguanylate cyclase
E2H98_RS01315	COG3300	MHYT domain
E2H98_RS01325	COG1942	4-Oxalocrotonate Tautomerase
E2H98_RS01350	COG1595	DNA-templated transcription, initiation
E2H98_RS01360	COG0454	-acetyltransferase
E2H98_RS01380	COG1278	Cold shock
E2H98_RS01425	COG1073	alpha beta
E2H98_RS01430	COG1725	Transcriptional regulator
E2H98_RS01435	COG1131	(ABC) transporter
E2H98_RS01455	COG1522	sequence-specific DNA binding
E2H98_RS01460	COG0625	glutathione transferase activity
E2H98_RS01470	COG3710	Transcriptional regulator
E2H98_RS01510	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E2H98_RS01550	COG3328	transposase activity
E2H98_RS01610	COG0567	Dehydrogenase, E1 component
E2H98_RS01615	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E2H98_RS01625	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
E2H98_RS01630	COG2009	succinate dehydrogenase
E2H98_RS01635	COG0372	Belongs to the citrate synthase family
E2H98_RS01645	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
E2H98_RS01655	COG1506	peptidase
E2H98_RS01655	COG0823	Involved in the tonB-independent uptake of proteins
E2H98_RS01670	COG0837	glucose binding
E2H98_RS01675	COG0363	glucosamine-6-phosphate deaminase activity
E2H98_RS01680	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
E2H98_RS01690	COG0800	Aldolase
E2H98_RS01695	COG0166	Belongs to the GPI family
E2H98_RS01710	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
E2H98_RS01715	COG1199	ATP-dependent helicase activity
E2H98_RS01735	COG1874	Beta-galactosidase
E2H98_RS01735	COG0366	Alpha amylase catalytic
E2H98_RS01745	COG0475	glutathione-regulated potassium exporter activity
E2H98_RS01785	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E2H98_RS01790	COG0366	Alpha amylase catalytic
E2H98_RS01795	COG1609	Transcriptional regulator
E2H98_RS01810	COG1446	asparaginase
E2H98_RS01815	COG3788	relative of glutathione S-transferase, MAPEG superfamily
E2H98_RS01825	COG0482	sulfurtransferase activity
E2H98_RS01830	COG0670	Belongs to the BI1 family
E2H98_RS01835	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
E2H98_RS01840	COG2923	Belongs to the DsrF TusC family
E2H98_RS01850	COG2920	part of a sulfur-relay system
E2H98_RS01860	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
E2H98_RS01935	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
E2H98_RS01935	COG0165	Argininosuccinate lyase
E2H98_RS01945	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E2H98_RS01955	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
E2H98_RS02000	COG1960	acyl-CoA dehydrogenase activity
E2H98_RS02015	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
E2H98_RS02030	COG0626	cystathionine gamma-synthase activity
E2H98_RS02055	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E2H98_RS02060	COG1959	2 iron, 2 sulfur cluster binding
E2H98_RS02095	COG2204	response regulator
E2H98_RS02110	COG0204	Acyl-transferase
E2H98_RS02120	COG1286	toxin biosynthetic process
E2H98_RS02130	COG0285	dihydrofolate synthase activity
E2H98_RS02135	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
E2H98_RS02145	COG2808	Putative FMN-binding domain
E2H98_RS02160	COG1278	Cold shock
E2H98_RS02170	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E2H98_RS02200	COG0316	Belongs to the HesB IscA family
E2H98_RS02205	COG0822	iron-sulfur transferase activity
E2H98_RS02210	COG1104	cysteine desulfurase activity
E2H98_RS02215	COG1959	2 iron, 2 sulfur cluster binding
E2H98_RS02245	COG0436	Aminotransferase
E2H98_RS02255	COG0302	gtp cyclohydrolase
E2H98_RS02260	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E2H98_RS02260	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
E2H98_RS02275	COG3101	peptidyl-lysine hydroxylation
E2H98_RS02295	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
E2H98_RS02300	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
E2H98_RS02325	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E2H98_RS02335	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E2H98_RS02340	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E2H98_RS02345	COG1862	Preprotein translocase
E2H98_RS02350	COG0343	queuine tRNA-ribosyltransferase activity
E2H98_RS02355	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
E2H98_RS02365	COG0587	DNA-directed DNA polymerase activity
E2H98_RS02385	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E2H98_RS02390	COG4969	Belongs to the N-Me-Phe pilin family
E2H98_RS02425	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
E2H98_RS02430	COG1047	Peptidyl-prolyl cis-trans
E2H98_RS02440	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E2H98_RS02445	COG0196	riboflavin kinase activity
E2H98_RS02450	COG0728	peptidoglycan biosynthetic process
E2H98_RS02455	COG0268	Binds directly to 16S ribosomal RNA
E2H98_RS02460	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E2H98_RS02465	COG0211	Belongs to the bacterial ribosomal protein bL27 family
E2H98_RS02470	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E2H98_RS02475	COG0142	geranyltranstransferase activity
E2H98_RS02510	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E2H98_RS02520	COG1090	epimerase
E2H98_RS02525	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
E2H98_RS02530	COG1012	belongs to the aldehyde dehydrogenase family
E2H98_RS02540	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
E2H98_RS02550	COG0456	acetyltransferase
E2H98_RS02555	COG0546	phosphoglycolate phosphatase activity
E2H98_RS02560	COG0564	pseudouridine synthase activity
E2H98_RS02570	COG1530	ribonuclease E activity
E2H98_RS02580	COG0277	FAD linked oxidase domain protein
E2H98_RS02585	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
E2H98_RS02590	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E2H98_RS02595	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
E2H98_RS02600	COG2835	tetraacyldisaccharide 4'-kinase activity
E2H98_RS02605	COG1663	tetraacyldisaccharide 4'-kinase activity
E2H98_RS02610	COG1132	(ABC) transporter
E2H98_RS02615	COG0848	biopolymer transport protein
E2H98_RS02620	COG0811	peptide transport
E2H98_RS02660	COG0668	transmembrane transport
E2H98_RS02665	COG1472	Belongs to the glycosyl hydrolase 3 family
E2H98_RS02690	COG0446	pyridine nucleotide-disulphide oxidoreductase
E2H98_RS02690	COG1902	pentaerythritol trinitrate reductase activity
E2H98_RS02695	COG0616	signal peptide processing
E2H98_RS02700	COG0252	asparaginase activity
E2H98_RS02715	COG3139	Protein of unknown function (DUF1315)
E2H98_RS02725	COG0730	response to heat
E2H98_RS02750	COG0438	transferase activity, transferring glycosyl groups
E2H98_RS02775	COG4137	Cytochrome C assembly protein
E2H98_RS02780	COG4536	flavin adenine dinucleotide binding
E2H98_RS02790	COG0625	glutathione transferase activity
E2H98_RS02830	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E2H98_RS02835	COG1459	type II secretion system
E2H98_RS02845	COG2165	general secretion pathway protein
E2H98_RS02880	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
E2H98_RS02920	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E2H98_RS02955	COG2983	Belongs to the UPF0260 family
E2H98_RS02960	COG0179	Fumarylacetoacetate (FAA) hydrolase
E2H98_RS02965	COG2951	lytic endotransglycosylase activity
E2H98_RS02970	COG3100	YcgL domain-containing protein
E2H98_RS02980	COG0318	PFAM AMP-dependent synthetase and ligase
E2H98_RS02985	COG0745	RESPONSE REGULATOR receiver
E2H98_RS02990	COG2267	carboxylic ester hydrolase activity
E2H98_RS03000	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E2H98_RS03005	COG1305	Transglutaminase-like
E2H98_RS03025	COG1012	belongs to the aldehyde dehydrogenase family
E2H98_RS03035	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
E2H98_RS03040	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E2H98_RS03040	COG3153	acetyltransferase
E2H98_RS03060	COG0004	ammonium transporteR
E2H98_RS03075	COG4206	TonB-dependent receptor
E2H98_RS03100	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E2H98_RS03105	COG0009	L-threonylcarbamoyladenylate synthase
E2H98_RS03125	COG2010	Cytochrome c
E2H98_RS03140	COG3038	cytochrome b561
E2H98_RS03145	COG2311	Membrane
E2H98_RS03195	COG3550	peptidyl-serine autophosphorylation
E2H98_RS03200	COG1396	sequence-specific DNA binding
E2H98_RS03215	COG0442	prolyl-tRNA aminoacylation
E2H98_RS03220	COG0741	lytic transglycosylase activity
E2H98_RS03235	COG0037	tRNA processing
E2H98_RS03250	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E2H98_RS03255	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E2H98_RS03260	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E2H98_RS03265	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E2H98_RS03270	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E2H98_RS03285	COG0750	zinc metalloprotease
E2H98_RS03290	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
E2H98_RS03295	COG0575	Belongs to the CDS family
E2H98_RS03300	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E2H98_RS03305	COG0233	cytoplasmic translational termination
E2H98_RS03310	COG0528	UMP kinase activity
E2H98_RS03320	COG0052	Belongs to the universal ribosomal protein uS2 family
E2H98_RS03330	COG0024	Methionine aminopeptidase
E2H98_RS03335	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
E2H98_RS03340	COG2171	N-acyltransferase activity
E2H98_RS03345	COG1393	Belongs to the ArsC family
E2H98_RS03350	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E2H98_RS03355	COG1876	peptidase activity
E2H98_RS03380	COG1028	Short-chain dehydrogenase reductase Sdr
E2H98_RS03405	COG0776	regulation of translation
E2H98_RS03410	COG0072	phenylalanine-tRNA ligase activity
E2H98_RS03415	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
E2H98_RS03425	COG0291	Belongs to the bacterial ribosomal protein bL35 family
E2H98_RS03430	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
E2H98_RS03435	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E2H98_RS03450	COG0717	Belongs to the dCTP deaminase family
E2H98_RS03465	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E2H98_RS03465	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E2H98_RS03475	COG4657	Part of a membrane complex involved in electron transport
E2H98_RS03480	COG2878	Part of a membrane complex involved in electron transport
E2H98_RS03485	COG4656	Part of a membrane complex involved in electron transport
E2H98_RS03490	COG4658	electron transport chain
E2H98_RS03495	COG4659	FMN binding
E2H98_RS03500	COG4660	Part of a membrane complex involved in electron transport
E2H98_RS03505	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E2H98_RS03515	COG1028	Short-chain dehydrogenase reductase Sdr
E2H98_RS03530	COG1131	(ABC) transporter
E2H98_RS03540	COG2855	membrane
E2H98_RS03565	COG3098	single-species biofilm formation
E2H98_RS03570	COG0653	protein targeting
E2H98_RS03575	COG0612	Peptidase, M16
E2H98_RS03580	COG1131	(ABC) transporter
E2H98_RS03635	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E2H98_RS03645	COG0180	Tryptophanyl-tRNA synthetase
E2H98_RS03675	COG0009	L-threonylcarbamoyladenylate synthase
E2H98_RS03680	COG0613	PHP domain protein
E2H98_RS03685	COG2917	probably involved in intracellular septation
E2H98_RS03690	COG2350	Protein conserved in bacteria
E2H98_RS03715	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
E2H98_RS03720	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
E2H98_RS03730	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
E2H98_RS03735	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
E2H98_RS03745	COG1846	Transcriptional regulator
E2H98_RS03755	COG2877	3-deoxy-8-phosphooctulonate synthase activity
E2H98_RS03760	COG0504	CTP synthase activity
E2H98_RS03770	COG4206	TonB-dependent receptor
E2H98_RS03775	COG3956	TIGRFAM MazG family protein
E2H98_RS03780	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E2H98_RS03785	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E2H98_RS03800	COG5002	protein histidine kinase activity
E2H98_RS03800	COG2205	protein histidine kinase activity
E2H98_RS03800	COG0784	Response regulator, receiver
E2H98_RS03805	COG0598	Magnesium transport protein CorA
E2H98_RS03815	COG0604	alcohol dehydrogenase
E2H98_RS03830	COG3104	oligopeptide transport
E2H98_RS03835	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E2H98_RS03840	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E2H98_RS03850	COG1012	belongs to the aldehyde dehydrogenase family
E2H98_RS03855	COG3724	N-succinylarginine dihydrolase activity
E2H98_RS03875	COG0616	signal peptide processing
E2H98_RS03885	COG2766	serine protein kinase
E2H98_RS03890	COG2718	Belongs to the UPF0229 family
E2H98_RS03895	COG2719	SpoVR family
E2H98_RS03900	COG2186	Transcriptional regulator
E2H98_RS03910	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E2H98_RS03920	COG0328	RNA-DNA hybrid ribonuclease activity
E2H98_RS03930	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E2H98_RS03935	COG1388	LysM domain
E2H98_RS03935	COG0741	lytic transglycosylase activity
E2H98_RS03940	COG1757	Na H antiporter
E2H98_RS03945	COG1054	Belongs to the UPF0176 family
E2H98_RS03960	COG0778	Nitroreductase
E2H98_RS03975	COG2205	protein histidine kinase activity
E2H98_RS03980	COG0745	RESPONSE REGULATOR receiver
E2H98_RS04005	COG0300	oxidoreductase activity
E2H98_RS04015	COG1666	GTP binding
E2H98_RS04055	COG0583	DNA-binding transcription factor activity
E2H98_RS04080	COG1595	DNA-templated transcription, initiation
E2H98_RS04110	COG1228	amidohydrolase
E2H98_RS04140	COG2301	Belongs to the HpcH HpaI aldolase family
E2H98_RS04145	COG2030	dehydratase
E2H98_RS04150	COG3706	GGDEF domain
E2H98_RS04155	COG3300	MHYT domain
E2H98_RS04155	COG5001	Diguanylate cyclase
E2H98_RS04160	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
E2H98_RS04160	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
E2H98_RS04165	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
E2H98_RS04175	COG2813	Specifically methylates the guanine in position
E2H98_RS04180	COG0700	Nucleoside recognition
E2H98_RS04185	COG0584	glycerophosphoryl diester phosphodiesterase
E2H98_RS04190	COG0393	Putative heavy-metal-binding
E2H98_RS04220	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
E2H98_RS04235	COG1228	amidohydrolase
E2H98_RS04265	COG0625	glutathione transferase activity
E2H98_RS04280	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
E2H98_RS04320	COG1228	amidohydrolase
E2H98_RS04330	COG2188	Transcriptional regulator
E2H98_RS04335	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
E2H98_RS04340	COG2986	histidine ammonia-lyase
E2H98_RS04360	COG0848	biopolymer transport protein
E2H98_RS04365	COG0811	peptide transport
E2H98_RS04370	COG0811	peptide transport
E2H98_RS04385	COG0457	Tetratricopeptide repeat
E2H98_RS04395	COG0747	negative chemotaxis
E2H98_RS04400	COG0601	transmembrane transport
E2H98_RS04405	COG4171	peptide transport system, permease
E2H98_RS04410	COG0444	Belongs to the ABC transporter superfamily
E2H98_RS04415	COG4608	Belongs to the ABC transporter superfamily
E2H98_RS04420	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E2H98_RS04425	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E2H98_RS04445	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E2H98_RS04450	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
E2H98_RS04455	COG0740	serine-type endopeptidase activity
E2H98_RS04460	COG0544	peptidyl-prolyl cis-trans isomerase activity
E2H98_RS04490	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
E2H98_RS04495	COG0469	pyruvate kinase activity
E2H98_RS04500	COG0204	Acyl-transferase
E2H98_RS04510	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E2H98_RS04550	COG2223	nitrite transmembrane transporter activity
E2H98_RS04555	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E2H98_RS04565	COG3850	Histidine kinase
E2H98_RS04565	COG3437	response regulator, receiver
E2H98_RS04565	COG2205	protein histidine kinase activity
E2H98_RS04565	COG4999	Histidine kinase
E2H98_RS04570	COG2204	response regulator
E2H98_RS04600	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
E2H98_RS04610	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E2H98_RS04635	COG0037	tRNA processing
E2H98_RS04640	COG0730	response to heat
E2H98_RS04680	COG0714	Associated with various cellular activities
E2H98_RS04700	COG2885	chlorophyll binding
E2H98_RS04710	COG0697	spore germination
E2H98_RS04715	COG4251	negative regulation of phosphorylation
E2H98_RS04715	COG3706	GGDEF domain
E2H98_RS04715	COG5001	Diguanylate cyclase
E2H98_RS04715	COG2203	Gaf domain
E2H98_RS04730	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E2H98_RS04735	COG0508	dehydrogenase complex catalyzes the overall conversion of
E2H98_RS04775	COG3023	N-Acetylmuramoyl-L-alanine amidase
E2H98_RS04820	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
E2H98_RS04830	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
E2H98_RS04835	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
E2H98_RS04840	COG0494	nUDIX hydrolase
E2H98_RS04845	COG0653	protein targeting
E2H98_RS04850	COG0739	heme binding
E2H98_RS04860	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
E2H98_RS04880	COG1181	Belongs to the D-alanine--D-alanine ligase family
E2H98_RS04885	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E2H98_RS04890	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E2H98_RS04895	COG0772	Belongs to the SEDS family
E2H98_RS04900	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E2H98_RS04905	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E2H98_RS04910	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E2H98_RS04925	COG3116	cell division
E2H98_RS04935	COG2001	Belongs to the MraZ family
E2H98_RS04980	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E2H98_RS04995	COG1643	Atp-dependent helicase
E2H98_RS05010	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E2H98_RS05035	COG4251	negative regulation of phosphorylation
E2H98_RS05065	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E2H98_RS05070	COG1845	cytochrome c oxidase, subunit III
E2H98_RS05075	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
E2H98_RS05080	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E2H98_RS05085	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E2H98_RS05090	COG0456	acetyltransferase
E2H98_RS05105	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
E2H98_RS05110	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E2H98_RS05120	COG1765	OsmC-like protein
E2H98_RS05140	COG0546	phosphoglycolate phosphatase activity
E2H98_RS05145	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E2H98_RS05170	COG0318	PFAM AMP-dependent synthetase and ligase
E2H98_RS05180	COG5507	3-demethylubiquinone-9 3-methyltransferase
E2H98_RS05190	COG1404	Belongs to the peptidase S8 family
E2H98_RS05195	COG2201	protein-glutamate methylesterase activity
E2H98_RS05230	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E2H98_RS05235	COG1722	exodeoxyribonuclease VII activity
E2H98_RS05240	COG0142	geranyltranstransferase activity
E2H98_RS05295	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
E2H98_RS05305	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
E2H98_RS05325	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E2H98_RS05325	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E2H98_RS05335	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E2H98_RS05350	COG0415	Belongs to the DNA photolyase family
E2H98_RS05360	COG1028	Short-chain dehydrogenase reductase Sdr
E2H98_RS05365	COG0493	'glutamate synthase
E2H98_RS05365	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
E2H98_RS05375	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E2H98_RS05395	COG1994	Peptidase M50
E2H98_RS05400	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E2H98_RS05405	COG0488	(ABC) transporter
E2H98_RS05415	COG0501	Belongs to the peptidase M48B family
E2H98_RS05420	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E2H98_RS05430	COG4535	Mg2 and Co2 transporter CorC
E2H98_RS05440	COG1702	phosphate starvation-inducible protein PhoH
E2H98_RS05445	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E2H98_RS05460	COG1519	Transferase
E2H98_RS05480	COG2914	Belongs to the UPF0125 (RnfH) family
E2H98_RS05485	COG2867	negative regulation of translational initiation
E2H98_RS05510	COG3384	dioxygenase
E2H98_RS05560	COG0438	transferase activity, transferring glycosyl groups
E2H98_RS05585	COG0488	(ABC) transporter
E2H98_RS05590	COG0513	Belongs to the DEAD box helicase family
E2H98_RS05595	COG0243	molybdopterin cofactor binding
E2H98_RS05605	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E2H98_RS05610	COG2223	nitrite transmembrane transporter activity
E2H98_RS05630	COG1560	Kdo2-lipid A biosynthetic process
E2H98_RS05645	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
E2H98_RS05645	COG0316	Belongs to the HesB IscA family
E2H98_RS05650	COG1505	serine-type exopeptidase activity
E2H98_RS05660	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E2H98_RS05670	COG3590	peptidase
E2H98_RS05680	COG0702	epimerase
E2H98_RS05720	COG0514	ATP-dependent DNA helicase (RecQ)
E2H98_RS05725	COG0471	metal ion transport
E2H98_RS05740	COG1404	Belongs to the peptidase S8 family
E2H98_RS05755	COG0085	RNA polymerase activity
E2H98_RS05760	COG0222	ribosome binding
E2H98_RS05765	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
E2H98_RS05770	COG0081	regulation of translation
E2H98_RS05775	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
E2H98_RS05780	COG0250	Participates in transcription elongation, termination and antitermination
E2H98_RS05785	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E2H98_RS05830	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
E2H98_RS05840	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E2H98_RS05870	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E2H98_RS05880	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
E2H98_RS05890	COG0316	Belongs to the HesB IscA family
E2H98_RS05910	COG1981	membrane
E2H98_RS05925	COG2188	Transcriptional regulator
E2H98_RS05960	COG1132	(ABC) transporter
E2H98_RS05965	COG1785	Belongs to the alkaline phosphatase family
E2H98_RS05980	COG3279	Response regulator of the LytR AlgR family
E2H98_RS05990	COG1773	rubredoxin
E2H98_RS06005	COG0351	phosphomethylpyrimidine kinase
E2H98_RS06010	COG1404	Belongs to the peptidase S8 family
E2H98_RS06020	COG0352	thiamine-phosphate diphosphorylase activity
E2H98_RS06025	COG0540	Belongs to the ATCase OTCase family
E2H98_RS06035	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E2H98_RS06045	COG1028	Short-chain dehydrogenase reductase Sdr
E2H98_RS06080	COG3844	kynureninase activity
E2H98_RS06085	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E2H98_RS06100	COG1294	oxidase, subunit
E2H98_RS06105	COG1271	oxidase subunit
E2H98_RS06125	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E2H98_RS06130	COG3978	acetolactate synthase activity
E2H98_RS06140	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
E2H98_RS06160	COG3107	peptidoglycan biosynthetic process
E2H98_RS06165	COG0792	nuclease activity
E2H98_RS06170	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
E2H98_RS06175	COG2823	Periplasmic or secreted lipoprotein
E2H98_RS06180	COG2969	positive regulation of protein catabolic process
E2H98_RS06185	COG2857	Cytochrome c1
E2H98_RS06190	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
E2H98_RS06195	COG0723	plastoquinol--plastocyanin reductase activity
E2H98_RS06200	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
E2H98_RS06205	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
E2H98_RS06215	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
E2H98_RS06230	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E2H98_RS06245	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
E2H98_RS06265	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E2H98_RS06280	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
E2H98_RS06285	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E2H98_RS06290	COG1983	PspC domain protein
E2H98_RS06295	COG3237	CsbD-like
E2H98_RS06305	COG3328	transposase activity
E2H98_RS06330	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E2H98_RS06335	COG0321	lipoyl(octanoyl) transferase activity
E2H98_RS06350	COG1686	Belongs to the peptidase S11 family
E2H98_RS06355	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E2H98_RS06360	COG2951	lytic endotransglycosylase activity
E2H98_RS06365	COG0772	Belongs to the SEDS family
E2H98_RS06370	COG0768	penicillin binding
E2H98_RS06375	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
E2H98_RS06380	COG0799	negative regulation of ribosome biogenesis
E2H98_RS06385	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
E2H98_RS06400	COG0495	leucyl-tRNA aminoacylation
E2H98_RS06405	COG1434	Gram-negative-bacterium-type cell wall biogenesis
E2H98_RS06425	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E2H98_RS06435	COG3275	phosphorelay sensor kinase activity
E2H98_RS06460	COG0305	Participates in initiation and elongation during chromosome replication
E2H98_RS06510	COG4251	negative regulation of phosphorylation
E2H98_RS06520	COG1943	Transposase
E2H98_RS06555	COG4974	Belongs to the 'phage' integrase family
E2H98_RS06560	COG0358	DNA primase activity
E2H98_RS06565	COG3620	sequence-specific DNA binding
E2H98_RS06590	COG3209	COG3209 Rhs family protein
E2H98_RS06600	COG4974	Belongs to the 'phage' integrase family
E2H98_RS06605	COG0358	DNA primase activity
E2H98_RS06610	COG3620	sequence-specific DNA binding
E2H98_RS06635	COG3209	COG3209 Rhs family protein
E2H98_RS06640	COG0217	transcriptional regulatory protein
E2H98_RS06650	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E2H98_RS06655	COG0360	Binds together with S18 to 16S ribosomal RNA
E2H98_RS06675	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E2H98_RS06680	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
E2H98_RS06685	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
E2H98_RS06690	COG0195	Participates in both transcription termination and antitermination
E2H98_RS06695	COG0779	Required for maturation of 30S ribosomal subunits
E2H98_RS06710	COG0671	phosphoesterase, PA-phosphatase related
E2H98_RS06715	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
E2H98_RS06730	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E2H98_RS06745	COG1185	polyribonucleotide nucleotidyltransferase activity
E2H98_RS06755	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E2H98_RS06765	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E2H98_RS06775	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E2H98_RS06780	COG0557	exoribonuclease II activity
E2H98_RS06790	COG0582	viral genome integration into host DNA
E2H98_RS06820	COG1752	Esterase of the alpha-beta hydrolase superfamily
E2H98_RS06825	COG0697	spore germination
E2H98_RS06835	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E2H98_RS06845	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E2H98_RS06865	COG0194	GDP metabolic process
E2H98_RS06870	COG1561	YicC-like family, N-terminal region
E2H98_RS06880	COG1047	Peptidyl-prolyl cis-trans
E2H98_RS06885	COG0308	aminopeptidase N
E2H98_RS06900	COG4221	oxidoreductase activity
E2H98_RS06915	COG0156	8-amino-7-oxononanoate synthase activity
E2H98_RS06920	COG0405	Gamma-glutamyltransferase
E2H98_RS06930	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E2H98_RS06950	COG1131	(ABC) transporter
E2H98_RS06960	COG1832	CoA-binding protein
E2H98_RS06970	COG0039	L-malate dehydrogenase activity
E2H98_RS06980	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E2H98_RS06990	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E2H98_RS07005	COG3409	Peptidoglycan-binding domain 1 protein
E2H98_RS07005	COG3267	Type II secretory pathway component ExeA
E2H98_RS07010	COG0617	tRNA 3'-terminal CCA addition
E2H98_RS07015	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E2H98_RS07020	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E2H98_RS07020	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E2H98_RS07045	COG0783	Belongs to the Dps family
E2H98_RS07050	COG1968	undecaprenyl-diphosphatase activity
E2H98_RS07065	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E2H98_RS07070	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E2H98_RS07085	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
E2H98_RS07090	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
E2H98_RS07110	COG1610	YqeY-like protein
E2H98_RS07120	COG0358	DNA primase activity
E2H98_RS07155	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
E2H98_RS07195	COG0583	DNA-binding transcription factor activity
E2H98_RS07205	COG2264	protein methyltransferase activity
E2H98_RS07240	COG0138	bifunctional purine biosynthesis protein purh
E2H98_RS07255	COG2824	Alkylphosphonate utilization operon protein PhnA
E2H98_RS07285	COG2133	pyrroloquinoline quinone binding
E2H98_RS07290	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E2H98_RS07295	COG3738	Protein conserved in bacteria
E2H98_RS07300	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
E2H98_RS07305	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E2H98_RS07325	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E2H98_RS07355	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
E2H98_RS07375	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
E2H98_RS07395	COG3135	benzoate transporter
E2H98_RS07400	COG1396	sequence-specific DNA binding
E2H98_RS07415	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E2H98_RS07445	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E2H98_RS07450	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
E2H98_RS07455	COG2962	Rard protein
E2H98_RS07460	COG2050	protein possibly involved in aromatic compounds catabolism
E2H98_RS07465	COG0596	Alpha beta hydrolase
E2H98_RS07480	COG0494	nUDIX hydrolase
E2H98_RS07495	COG0564	pseudouridine synthase activity
E2H98_RS07505	COG1196	nuclear chromosome segregation
E2H98_RS07505	COG3264	Mechanosensitive ion channel
E2H98_RS07525	COG3795	YCII-related domain
E2H98_RS07530	COG3795	YCII-related domain
E2H98_RS07535	COG4941	Belongs to the sigma-70 factor family
E2H98_RS07540	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
E2H98_RS07585	COG1324	tolerance protein
E2H98_RS07590	COG4232	protein-disulfide reductase activity
E2H98_RS07630	COG2818	Glycosylase
E2H98_RS07640	COG0752	glycyl-tRNA synthetase alpha subunit
E2H98_RS07645	COG0751	glycine-tRNA ligase activity
E2H98_RS07700	COG0367	asparagine synthase
E2H98_RS07705	COG1522	sequence-specific DNA binding
E2H98_RS07725	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E2H98_RS07740	COG2207	Transcriptional regulator
E2H98_RS07780	COG0577	efflux transmembrane transporter activity
E2H98_RS07785	COG0577	efflux transmembrane transporter activity
E2H98_RS07785	COG1136	(ABC) transporter
E2H98_RS07790	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E2H98_RS07800	COG1228	amidohydrolase
E2H98_RS07815	COG0840	transmembrane signaling receptor activity
E2H98_RS07820	COG1218	3'(2'),5'-bisphosphate nucleotidase
E2H98_RS07825	COG0494	nUDIX hydrolase
E2H98_RS07830	COG1011	Hydrolase
E2H98_RS07870	COG2165	general secretion pathway protein
E2H98_RS07875	COG1459	type II secretion system
E2H98_RS07890	COG3031	protein transport across the cell outer membrane
E2H98_RS07895	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
E2H98_RS07905	COG2197	response regulator
E2H98_RS07910	COG3706	GGDEF domain
E2H98_RS07935	COG2183	response to ionizing radiation
E2H98_RS07945	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
E2H98_RS07950	COG0543	2 iron, 2 sulfur cluster binding
E2H98_RS07950	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E2H98_RS07955	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
E2H98_RS07965	COG3118	belongs to the thioredoxin family
E2H98_RS07970	COG0513	Belongs to the DEAD box helicase family
E2H98_RS07985	COG1073	alpha beta
E2H98_RS07995	COG0392	lysyltransferase activity
E2H98_RS08005	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
E2H98_RS08050	COG2274	protein secretion by the type I secretion system
E2H98_RS08055	COG1538	Outer membrane efflux protein
E2H98_RS08065	COG0633	Ferredoxin
E2H98_RS08065	COG3217	Mosc domain protein beta barrel domain protein
E2H98_RS08085	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E2H98_RS08090	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E2H98_RS08095	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
E2H98_RS08100	COG0742	ribosomal rna small subunit methyltransferase
E2H98_RS08120	COG0604	alcohol dehydrogenase
E2H98_RS08150	COG3706	GGDEF domain
E2H98_RS08160	COG2217	Heavy metal translocating P-type atpase
E2H98_RS08180	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
E2H98_RS08190	COG1872	DUF167
E2H98_RS08235	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E2H98_RS08240	COG1288	antiporter activity
E2H98_RS08245	COG4206	TonB-dependent receptor
E2H98_RS08260	COG2267	carboxylic ester hydrolase activity
E2H98_RS08265	COG3275	phosphorelay sensor kinase activity
E2H98_RS08270	COG3279	Response regulator of the LytR AlgR family
E2H98_RS08290	COG0405	Gamma-glutamyltransferase
E2H98_RS08315	COG1363	Peptidase, m42
E2H98_RS08320	COG0189	ligase activity
E2H98_RS08320	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E2H98_RS08325	COG0367	asparagine synthase
E2H98_RS08330	COG1846	Transcriptional regulator
E2H98_RS08350	COG0833	amino acid
E2H98_RS08385	COG1671	Belongs to the UPF0178 family
E2H98_RS08395	COG0861	Integral membrane protein TerC family
E2H98_RS08400	COG1024	Enoyl-CoA hydratase
E2H98_RS08405	COG0488	(ABC) transporter
E2H98_RS08435	COG1585	Membrane protein implicated in regulation of membrane protease activity
E2H98_RS08440	COG2268	Band 7 protein
E2H98_RS08505	COG0346	lactoylglutathione lyase activity
E2H98_RS08540	COG3706	GGDEF domain
E2H98_RS08560	COG2202	Pas domain
E2H98_RS08560	COG2205	protein histidine kinase activity
E2H98_RS08595	COG0714	Associated with various cellular activities
E2H98_RS08665	COG4771	TonB-dependent receptor
E2H98_RS08675	COG1858	cytochrome C peroxidase
E2H98_RS08705	COG1309	transcriptional regulator
E2H98_RS08715	COG1131	(ABC) transporter
E2H98_RS08720	COG0842	Transport permease protein
E2H98_RS08725	COG4989	oxidoreductase activity
E2H98_RS08765	COG0583	DNA-binding transcription factor activity
E2H98_RS08780	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E2H98_RS08795	COG0746	molybdenum cofactor guanylyltransferase activity
E2H98_RS08800	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
E2H98_RS08825	COG1764	response to oxidative stress
E2H98_RS08830	COG1285	pathogenesis
E2H98_RS08840	COG3279	Response regulator of the LytR AlgR family
E2H98_RS08865	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
E2H98_RS08935	COG0531	amino acid
E2H98_RS08945	COG0789	Transcriptional regulator
E2H98_RS08955	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E2H98_RS08965	COG1943	Transposase
E2H98_RS09035	COG3647	Membrane
E2H98_RS09040	COG5001	Diguanylate cyclase
E2H98_RS09055	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
E2H98_RS09060	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
E2H98_RS09075	COG0596	Alpha beta hydrolase
E2H98_RS09145	COG0366	Alpha amylase catalytic
E2H98_RS09145	COG3103	Sh3 type 3 domain protein
E2H98_RS09180	COG3710	Transcriptional regulator
E2H98_RS09290	COG0583	DNA-binding transcription factor activity
E2H98_RS09300	COG2203	Gaf domain
E2H98_RS09300	COG4251	negative regulation of phosphorylation
E2H98_RS09300	COG3706	GGDEF domain
E2H98_RS09300	COG5001	Diguanylate cyclase
E2H98_RS09320	COG3093	addiction module antidote protein HigA
E2H98_RS09330	COG4249	Peptidase C14 caspase catalytic subunit p20
E2H98_RS09330	COG2319	Wd-40 repeat
E2H98_RS09340	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
E2H98_RS09355	COG4232	protein-disulfide reductase activity
E2H98_RS09365	COG0789	Transcriptional regulator
E2H98_RS09370	COG1690	Belongs to the RtcB family
E2H98_RS09385	COG4650	regulator
E2H98_RS09390	COG2801	Transposase and inactivated derivatives
E2H98_RS09410	COG3552	Protein containing von Willebrand factor type A (VWA) domain
E2H98_RS09420	COG0714	Associated with various cellular activities
E2H98_RS09425	COG3831	ATPase activity
E2H98_RS09455	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
E2H98_RS09465	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E2H98_RS09470	COG0230	Belongs to the bacterial ribosomal protein bL34 family
E2H98_RS09475	COG0594	ribonuclease P activity
E2H98_RS09480	COG0706	membrane insertase activity
E2H98_RS09490	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
E2H98_RS09500	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E2H98_RS09515	COG0626	cystathionine gamma-synthase activity
E2H98_RS09525	COG4953	penicillin-binding protein 1C
E2H98_RS09530	COG0445	tRNA wobble uridine modification
E2H98_RS09560	COG0357	Ribosomal RNA small subunit methyltransferase G
E2H98_RS09565	COG1192	Involved in chromosome partitioning
E2H98_RS09570	COG1475	DNA binding
E2H98_RS09580	COG1301	dicarboxylic acid transport
E2H98_RS09585	COG1301	dicarboxylic acid transport
E2H98_RS09600	COG0356	it plays a direct role in the translocation of protons across the membrane
E2H98_RS09610	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
E2H98_RS09615	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E2H98_RS09620	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
E2H98_RS09630	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
E2H98_RS09635	COG0355	proton-transporting ATP synthase activity, rotational mechanism
E2H98_RS09640	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
E2H98_RS09645	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E2H98_RS09650	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E2H98_RS09665	COG2066	Belongs to the glutaminase family
E2H98_RS09680	COG1560	Kdo2-lipid A biosynthetic process
E2H98_RS09690	COG2207	Transcriptional regulator
E2H98_RS09690	COG4753	response regulator
E2H98_RS09695	COG2205	protein histidine kinase activity
E2H98_RS09695	COG5002	protein histidine kinase activity
E2H98_RS09695	COG0784	Response regulator, receiver
E2H98_RS09700	COG0569	domain protein
E2H98_RS09705	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E2H98_RS09705	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E2H98_RS09710	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E2H98_RS09715	COG0242	peptide deformylase activity
E2H98_RS09725	COG0758	DNA mediated transformation
E2H98_RS09730	COG0408	coproporphyrinogen oxidase activity
E2H98_RS09750	COG1607	acyl-coa hydrolase
E2H98_RS09770	COG3655	Transcriptional regulator
E2H98_RS09785	COG0218	Necessary for normal cell division and for the maintenance of normal septation
E2H98_RS09790	COG1136	(ABC) transporter
E2H98_RS09810	COG0577	efflux transmembrane transporter activity
E2H98_RS09810	COG1136	(ABC) transporter
E2H98_RS09845	COG1132	(ABC) transporter
E2H98_RS09855	COG0701	Predicted permease
E2H98_RS09860	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
E2H98_RS09935	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
E2H98_RS09945	COG0436	Aminotransferase
E2H98_RS09955	COG1733	regulation of RNA biosynthetic process
E2H98_RS09960	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
E2H98_RS09965	COG0823	Involved in the tonB-independent uptake of proteins
E2H98_RS09965	COG1506	peptidase
E2H98_RS09965	COG4946	Tricorn protease homolog
E2H98_RS09970	COG0210	DNA helicase
E2H98_RS09975	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E2H98_RS09980	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
E2H98_RS10025	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E2H98_RS10045	COG3328	transposase activity
E2H98_RS10060	COG1757	Na H antiporter
E2H98_RS10065	COG0488	(ABC) transporter
E2H98_RS10070	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
E2H98_RS10075	COG2801	Transposase and inactivated derivatives
E2H98_RS10085	COG1595	DNA-templated transcription, initiation
E2H98_RS10115	COG3739	integral membrane protein
E2H98_RS10125	COG2304	oxidoreductase activity
E2H98_RS10155	COG0288	reversible hydration of carbon dioxide
E2H98_RS10160	COG2329	Antibiotic biosynthesis monooxygenase
E2H98_RS10185	COG1070	Carbohydrate kinase
E2H98_RS10200	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E2H98_RS10205	COG0589	response to stress
E2H98_RS10215	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E2H98_RS10220	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
E2H98_RS10240	COG0281	malic enzyme
E2H98_RS10250	COG0254	rRNA binding
E2H98_RS10265	COG4771	TonB-dependent receptor
E2H98_RS10275	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E2H98_RS10290	COG1678	Uncharacterized ACR, COG1678
E2H98_RS10325	COG0840	transmembrane signaling receptor activity
E2H98_RS10335	COG2198	Histidine kinase
E2H98_RS10335	COG0643	Histidine kinase
E2H98_RS10335	COG0784	Response regulator, receiver
E2H98_RS10340	COG2201	protein-glutamate methylesterase activity
E2H98_RS10350	COG3706	GGDEF domain
E2H98_RS10355	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E2H98_RS10365	COG0069	glutamate synthase activity
E2H98_RS10380	COG1404	Belongs to the peptidase S8 family
E2H98_RS10385	COG1404	Belongs to the peptidase S8 family
E2H98_RS10400	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E2H98_RS10405	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E2H98_RS10410	COG0126	phosphoglycerate kinase activity
E2H98_RS10415	COG0191	fructose-bisphosphate aldolase activity
E2H98_RS10420	COG1183	phosphatidylcholine synthase activity
E2H98_RS10430	COG4104	PAAR repeat-containing protein
E2H98_RS10465	COG2205	protein histidine kinase activity
E2H98_RS10465	COG0784	Response regulator, receiver
E2H98_RS10475	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E2H98_RS10515	COG0438	transferase activity, transferring glycosyl groups
E2H98_RS10520	COG0367	asparagine synthase
E2H98_RS10535	COG0438	transferase activity, transferring glycosyl groups
E2H98_RS10620	COG0745	RESPONSE REGULATOR receiver
E2H98_RS10625	COG2205	protein histidine kinase activity
E2H98_RS10655	COG2204	response regulator
E2H98_RS10690	COG2205	protein histidine kinase activity
E2H98_RS10715	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
E2H98_RS10730	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E2H98_RS10745	COG0084	hydrolase, TatD family'
E2H98_RS10800	COG1490	D-aminoacyl-tRNA deacylase activity
E2H98_RS10805	COG2207	Transcriptional regulator
E2H98_RS10810	COG3275	phosphorelay sensor kinase activity
E2H98_RS10815	COG3279	Response regulator of the LytR AlgR family
E2H98_RS10830	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
E2H98_RS10835	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
E2H98_RS10840	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
E2H98_RS10845	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E2H98_RS10850	COG1585	Membrane protein implicated in regulation of membrane protease activity
E2H98_RS10855	COG0330	HflC and HflK could
E2H98_RS10865	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
E2H98_RS10870	COG4942	peptidase
E2H98_RS10875	COG0793	Belongs to the peptidase S41A family
E2H98_RS10880	COG2861	carbohydrate metabolic process
E2H98_RS10900	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E2H98_RS10915	COG0606	chelatase, subunit chli
E2H98_RS11060	COG0606	chelatase, subunit chli
E2H98_RS11065	COG2960	long-chain fatty acid transporting porin activity
E2H98_RS11075	COG1166	arginine decarboxylase activity
E2H98_RS11105	COG1355	regulation of microtubule-based process
E2H98_RS11115	COG0006	proline dipeptidase activity
E2H98_RS11120	COG1250	3-hydroxyacyl-CoA dehydrogenase
E2H98_RS11120	COG1024	Enoyl-CoA hydratase
E2H98_RS11125	COG0183	Belongs to the thiolase family
E2H98_RS11140	COG2326	polyphosphate kinase activity
E2H98_RS11180	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
E2H98_RS11220	COG4977	sequence-specific DNA binding
E2H98_RS11270	COG0739	heme binding
E2H98_RS11295	COG1253	flavin adenine dinucleotide binding
E2H98_RS11325	COG2971	BadF BadG BcrA BcrD
E2H98_RS11330	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E2H98_RS11335	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E2H98_RS11355	COG1609	Transcriptional regulator
E2H98_RS11365	COG0735	belongs to the Fur family
E2H98_RS11390	COG2095	MarC family integral membrane protein
E2H98_RS11400	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
E2H98_RS11405	COG1704	LemA family
E2H98_RS11410	COG0501	Belongs to the peptidase M48B family
E2H98_RS11430	COG2153	protein acetylation
E2H98_RS11435	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E2H98_RS11440	COG2203	Gaf domain
E2H98_RS11440	COG5001	Diguanylate cyclase
E2H98_RS11440	COG4251	negative regulation of phosphorylation
E2H98_RS11440	COG3706	GGDEF domain
E2H98_RS11460	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
E2H98_RS11490	COG2862	Uncharacterized protein family, UPF0114
E2H98_RS11505	COG0784	Response regulator, receiver
E2H98_RS11505	COG2198	Histidine kinase
E2H98_RS11505	COG2205	protein histidine kinase activity
E2H98_RS11520	COG0450	alkyl hydroperoxide reductase
E2H98_RS11530	COG2974	May be involved in recombination
E2H98_RS11540	COG0534	Mate efflux family protein
E2H98_RS11555	COG1648	precorrin-2 dehydrogenase activity
E2H98_RS11555	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E2H98_RS11570	COG2205	protein histidine kinase activity
E2H98_RS11595	COG0439	Biotin carboxylase
E2H98_RS11600	COG0511	ligase activity, forming carbon-carbon bonds
E2H98_RS11605	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
E2H98_RS11620	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
E2H98_RS11625	COG4988	ABC transporter
E2H98_RS11635	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E2H98_RS11650	COG2197	response regulator
E2H98_RS11655	COG4585	Histidine kinase
E2H98_RS11660	COG0545	Peptidyl-prolyl cis-trans isomerase
E2H98_RS11670	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
E2H98_RS11695	COG0668	transmembrane transport
E2H98_RS11705	COG2177	Part of the ABC transporter FtsEX involved in
E2H98_RS11710	COG2884	Cell division ATP-binding protein ftsE
E2H98_RS11715	COG2311	Membrane
E2H98_RS11725	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E2H98_RS11730	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E2H98_RS11750	COG0006	proline dipeptidase activity
E2H98_RS11755	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E2H98_RS11770	COG0204	Acyl-transferase
E2H98_RS11775	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E2H98_RS11780	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E2H98_RS11790	COG0318	PFAM AMP-dependent synthetase and ligase
E2H98_RS11805	COG2986	histidine ammonia-lyase
E2H98_RS11840	COG1028	Short-chain dehydrogenase reductase Sdr
E2H98_RS11845	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E2H98_RS11860	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E2H98_RS11880	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E2H98_RS11880	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E2H98_RS11895	COG0596	Alpha beta hydrolase
E2H98_RS11915	COG1217	gtp-binding protein TYPA
E2H98_RS11925	COG3706	GGDEF domain
E2H98_RS11930	COG0482	sulfurtransferase activity
E2H98_RS11950	COG0174	glutamine synthetase
E2H98_RS11970	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
E2H98_RS12005	COG1611	Belongs to the LOG family
E2H98_RS12025	COG3072	Adenylate cyclase
E2H98_RS12035	COG3275	phosphorelay sensor kinase activity
E2H98_RS12045	COG0181	hydroxymethylbilane synthase activity
E2H98_RS12050	COG1587	Uroporphyrinogen-III synthase
E2H98_RS12060	COG3071	HemY protein
E2H98_RS12075	COG1950	PFAM Membrane protein of
E2H98_RS12080	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E2H98_RS12085	COG0018	arginyl-trna synthetase
E2H98_RS12095	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
E2H98_RS12100	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
E2H98_RS12110	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E2H98_RS12125	COG2852	Protein conserved in bacteria
E2H98_RS12145	COG4555	ABC transporter
E2H98_RS12150	COG1668	transmembrane transport
E2H98_RS12170	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
E2H98_RS12175	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E2H98_RS12190	COG0531	amino acid
E2H98_RS12195	COG2235	arginine
E2H98_RS12200	COG4638	Rieske (2fe-2S)
E2H98_RS12255	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
E2H98_RS12280	COG2204	response regulator
E2H98_RS12285	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E2H98_RS12295	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
E2H98_RS12310	COG0515	serine threonine protein kinase
E2H98_RS12310	COG2815	serine threonine protein kinase
E2H98_RS12325	COG0631	protein serine/threonine phosphatase activity
E2H98_RS12335	COG0189	ligase activity
E2H98_RS12340	COG4067	protein conserved in archaea
E2H98_RS12340	COG0189	ligase activity
E2H98_RS12370	COG2022	thiamine diphosphate biosynthetic process
E2H98_RS12375	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E2H98_RS12395	COG0322	excinuclease ABC activity
E2H98_RS12400	COG1074	ATP-dependent DNA helicase activity
E2H98_RS12415	COG0742	ribosomal rna small subunit methyltransferase
E2H98_RS12420	COG0552	protein localization to endoplasmic reticulum
E2H98_RS12425	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E2H98_RS12430	COG0227	Belongs to the bacterial ribosomal protein bL28 family
E2H98_RS12435	COG2003	Belongs to the UPF0758 family
E2H98_RS12440	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E2H98_RS12445	COG0756	dUTP diphosphatase activity
E2H98_RS12455	COG1309	transcriptional regulator
E2H98_RS12470	COG0708	Exodeoxyribonuclease III
E2H98_RS12480	COG0678	peroxiredoxin activity
E2H98_RS12485	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E2H98_RS12490	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
E2H98_RS12495	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E2H98_RS12500	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
E2H98_RS12505	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
E2H98_RS12545	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
E2H98_RS12550	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
E2H98_RS12575	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
E2H98_RS12585	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
E2H98_RS12590	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E2H98_RS12600	COG1278	Cold shock
E2H98_RS12620	COG1522	sequence-specific DNA binding
E2H98_RS12655	COG0848	biopolymer transport protein
E2H98_RS12665	COG0730	response to heat
E2H98_RS12670	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
E2H98_RS12675	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
E2H98_RS12680	COG0784	Response regulator, receiver
E2H98_RS12680	COG2205	protein histidine kinase activity
E2H98_RS12680	COG5002	protein histidine kinase activity
E2H98_RS12715	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E2H98_RS12720	COG0640	Transcriptional regulator
E2H98_RS12735	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E2H98_RS12750	COG1648	precorrin-2 dehydrogenase activity
E2H98_RS12750	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E2H98_RS12755	COG0583	DNA-binding transcription factor activity
E2H98_RS12785	COG0459	protein refolding
E2H98_RS12790	COG4251	negative regulation of phosphorylation
E2H98_RS12795	COG0625	glutathione transferase activity
E2H98_RS12825	COG0739	heme binding
E2H98_RS12850	COG0497	DNA recombination
E2H98_RS12865	COG1040	competence protein
E2H98_RS12875	COG0156	8-amino-7-oxononanoate synthase activity
E2H98_RS12885	COG2226	methyltransferase
E2H98_RS12905	COG0338	D12 class N6 adenine-specific DNA methyltransferase
E2H98_RS12910	COG3243	poly(R)-hydroxyalkanoic acid synthase
E2H98_RS12930	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
E2H98_RS12955	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E2H98_RS12965	COG1162	GTPase activity
E2H98_RS12970	COG2154	pterin-4-alpha-carbinolamine dehydratase
E2H98_RS12975	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
E2H98_RS12980	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E2H98_RS12980	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E2H98_RS12985	COG0802	atpase or kinase
E2H98_RS12995	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
E2H98_RS13000	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E2H98_RS13005	COG1923	regulation of RNA biosynthetic process
E2H98_RS13010	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E2H98_RS13015	COG0330	HflC and HflK could
E2H98_RS13020	COG0330	HflC and HflK could
E2H98_RS13030	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
E2H98_RS13045	COG3710	Transcriptional regulator
E2H98_RS13075	COG2318	DinB family
E2H98_RS13080	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
E2H98_RS13095	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E2H98_RS13110	COG2815	serine threonine protein kinase
E2H98_RS13110	COG0515	serine threonine protein kinase
E2H98_RS13125	COG0583	DNA-binding transcription factor activity
E2H98_RS13165	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E2H98_RS13170	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E2H98_RS13190	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
E2H98_RS13195	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
E2H98_RS13210	COG0505	Belongs to the CarA family
E2H98_RS13220	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E2H98_RS13225	COG1534	Rna-binding protein
E2H98_RS13230	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
E2H98_RS13235	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E2H98_RS13245	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E2H98_RS13250	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E2H98_RS13280	COG0149	triose-phosphate isomerase activity
E2H98_RS13285	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E2H98_RS13300	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E2H98_RS13305	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E2H98_RS13310	COG0649	NAD binding
E2H98_RS13325	COG1034	ATP synthesis coupled electron transport
E2H98_RS13330	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
E2H98_RS13335	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E2H98_RS13345	COG0713	ATP synthesis coupled electron transport
E2H98_RS13360	COG1007	ATP synthesis coupled electron transport
E2H98_RS13425	COG0560	Phosphoserine phosphatase
E2H98_RS13430	COG5001	Diguanylate cyclase
E2H98_RS13430	COG5002	protein histidine kinase activity
E2H98_RS13440	COG1509	lysine 2,3-aminomutase activity
E2H98_RS13445	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E2H98_RS13455	COG0745	RESPONSE REGULATOR receiver
E2H98_RS13465	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
E2H98_RS13470	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
E2H98_RS13490	COG0688	phosphatidylethanolamine metabolic process
E2H98_RS13495	COG0586	Pfam SNARE associated Golgi protein
E2H98_RS13500	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
E2H98_RS13515	COG2205	protein histidine kinase activity
E2H98_RS13515	COG0784	Response regulator, receiver
E2H98_RS13515	COG5002	protein histidine kinase activity
E2H98_RS13525	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
E2H98_RS13535	COG0840	transmembrane signaling receptor activity
E2H98_RS13540	COG0835	chemotaxis
E2H98_RS13545	COG0643	Histidine kinase
E2H98_RS13545	COG2198	Histidine kinase
E2H98_RS13550	COG0745	RESPONSE REGULATOR receiver
E2H98_RS13555	COG0745	RESPONSE REGULATOR receiver
E2H98_RS13565	COG3273	potassium ion transport
E2H98_RS13565	COG0471	metal ion transport
E2H98_RS13585	COG1420	regulation of RNA biosynthetic process
E2H98_RS13600	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E2H98_RS13610	COG0484	heat shock protein binding
E2H98_RS13635	COG1573	uracil-dna glycosylase
E2H98_RS13655	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
E2H98_RS13660	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
E2H98_RS13665	COG1428	Deoxynucleoside kinase
E2H98_RS13670	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
E2H98_RS13675	COG0617	tRNA 3'-terminal CCA addition
E2H98_RS13680	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E2H98_RS13695	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E2H98_RS13710	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E2H98_RS13715	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E2H98_RS13720	COG1077	Cell shape determining protein MreB Mrl
E2H98_RS13725	COG1792	Involved in formation and maintenance of cell shape
E2H98_RS13730	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
E2H98_RS13735	COG0424	maF-like protein
E2H98_RS13750	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E2H98_RS13755	COG0312	modulator of DNA gyrase
E2H98_RS13760	COG3028	Belongs to the UPF0307 family
E2H98_RS13770	COG0312	modulator of DNA gyrase
E2H98_RS13775	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
E2H98_RS13780	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E2H98_RS13785	COG2239	Acts as a magnesium transporter
E2H98_RS13795	COG1660	Displays ATPase and GTPase activities
E2H98_RS13805	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
E2H98_RS13810	COG1137	ATPase activity
E2H98_RS13825	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
E2H98_RS13835	COG1127	ABC transporter
E2H98_RS13840	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E2H98_RS13845	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E2H98_RS13855	COG3113	response to antibiotic
E2H98_RS13860	COG5007	Belongs to the BolA IbaG family
E2H98_RS13865	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E2H98_RS13875	COG0745	RESPONSE REGULATOR receiver
E2H98_RS13895	COG3275	phosphorelay sensor kinase activity
E2H98_RS13900	COG3279	Response regulator of the LytR AlgR family
E2H98_RS13915	COG3046	protein related to deoxyribodipyrimidine photolyase
E2H98_RS13925	COG0330	HflC and HflK could
E2H98_RS13950	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E2H98_RS13955	COG0640	Transcriptional regulator
E2H98_RS13970	COG1960	acyl-CoA dehydrogenase activity
E2H98_RS14015	COG1959	2 iron, 2 sulfur cluster binding
E2H98_RS14020	COG5002	protein histidine kinase activity
E2H98_RS14030	COG5487	UPF0391 membrane protein
E2H98_RS14035	COG2823	Periplasmic or secreted lipoprotein
E2H98_RS14045	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
E2H98_RS14055	COG0471	metal ion transport
E2H98_RS14055	COG3273	potassium ion transport
E2H98_RS14065	COG2010	Cytochrome c
E2H98_RS14065	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E2H98_RS14070	COG0545	Peptidyl-prolyl cis-trans isomerase
E2H98_RS14095	COG1131	(ABC) transporter
E2H98_RS14100	COG1725	Transcriptional regulator
E2H98_RS14160	COG0193	aminoacyl-tRNA hydrolase activity
E2H98_RS14180	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
E2H98_RS14195	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
E2H98_RS14200	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E2H98_RS14205	COG2890	protein-(glutamine-N5) methyltransferase activity
E2H98_RS14210	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E2H98_RS14215	COG1566	PFAM secretion protein HlyD family protein
E2H98_RS14220	COG1136	(ABC) transporter
E2H98_RS14230	COG0577	efflux transmembrane transporter activity
E2H98_RS14235	COG1253	flavin adenine dinucleotide binding
E2H98_RS14280	COG1794	racemase activity, acting on amino acids and derivatives
E2H98_RS14285	COG2076	Multidrug Resistance protein
E2H98_RS14295	COG1917	Cupin 2, conserved barrel domain protein
E2H98_RS14295	COG1396	sequence-specific DNA binding
E2H98_RS14370	COG0789	Transcriptional regulator
E2H98_RS14385	COG1280	lysine exporter protein (LysE YggA)
E2H98_RS14395	COG3012	SEC-C Motif Domain Protein
E2H98_RS14430	COG4771	TonB-dependent receptor
E2H98_RS14460	COG1612	heme a metabolic process
E2H98_RS14465	COG0109	protoheme IX farnesyltransferase activity
E2H98_RS14470	COG1999	signal sequence binding
E2H98_RS14475	COG2197	response regulator
E2H98_RS14480	COG4585	Histidine kinase
E2H98_RS14500	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
E2H98_RS14505	COG1538	Outer membrane efflux protein
E2H98_RS14510	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
E2H98_RS14515	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
E2H98_RS14525	COG0494	nUDIX hydrolase
E2H98_RS14545	COG1595	DNA-templated transcription, initiation
E2H98_RS14570	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E2H98_RS14590	COG1595	DNA-templated transcription, initiation
E2H98_RS14605	COG1752	Esterase of the alpha-beta hydrolase superfamily
E2H98_RS14610	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
E2H98_RS14625	COG0842	Transport permease protein
E2H98_RS14630	COG1131	(ABC) transporter
E2H98_RS14635	COG5001	Diguanylate cyclase
E2H98_RS14635	COG3300	MHYT domain
E2H98_RS14640	COG0163	prenyltransferase activity
E2H98_RS14645	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E2H98_RS14655	COG0205	6-phosphofructokinase activity
E2H98_RS14670	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
E2H98_RS14675	COG0049	tRNA binding
E2H98_RS14680	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E2H98_RS14690	COG0051	transcription antitermination factor activity, RNA binding
E2H98_RS14700	COG0088	Forms part of the polypeptide exit tunnel
E2H98_RS14705	COG0089	rRNA binding
E2H98_RS14710	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
E2H98_RS14720	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
E2H98_RS14725	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
E2H98_RS14730	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
E2H98_RS14735	COG0255	Belongs to the universal ribosomal protein uL29 family
E2H98_RS14740	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
E2H98_RS14745	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
E2H98_RS14750	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
E2H98_RS14755	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
E2H98_RS14760	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
E2H98_RS14765	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E2H98_RS14770	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
E2H98_RS14775	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
E2H98_RS14785	COG1841	ribosomal large subunit assembly
E2H98_RS14790	COG0200	Binds to the 23S rRNA
E2H98_RS14795	COG0201	protein transport
E2H98_RS14805	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E2H98_RS14810	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
E2H98_RS14815	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
E2H98_RS14825	COG0203	ribosomal protein L17
E2H98_RS14850	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E2H98_RS14865	COG0577	efflux transmembrane transporter activity
E2H98_RS14870	COG0577	efflux transmembrane transporter activity
E2H98_RS14870	COG1136	(ABC) transporter
E2H98_RS14895	COG2200	EAL domain
E2H98_RS14910	COG0573	inorganic phosphate transmembrane transporter activity
E2H98_RS14915	COG0573	inorganic phosphate transmembrane transporter activity
E2H98_RS14920	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E2H98_RS14925	COG0704	Plays a role in the regulation of phosphate uptake
E2H98_RS14930	COG0745	RESPONSE REGULATOR receiver
E2H98_RS14975	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
E2H98_RS14980	COG3040	lipid binding
E2H98_RS14985	COG1028	Short-chain dehydrogenase reductase Sdr
E2H98_RS15030	COG0513	Belongs to the DEAD box helicase family
E2H98_RS15055	COG1309	transcriptional regulator
E2H98_RS15060	COG2124	cytochrome p450
E2H98_RS15075	COG1902	pentaerythritol trinitrate reductase activity
E2H98_RS15100	COG2515	1-aminocyclopropane-1-carboxylate deaminase
E2H98_RS15105	COG1131	(ABC) transporter
E2H98_RS15110	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E2H98_RS15125	COG0589	response to stress
E2H98_RS15130	COG3328	transposase activity
E2H98_RS15150	COG2223	nitrite transmembrane transporter activity
E2H98_RS15155	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
E2H98_RS15160	COG1140	nitrate reductase beta subunit
E2H98_RS15165	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
E2H98_RS15170	COG2181	nitrate reductase activity
E2H98_RS15175	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E2H98_RS15210	COG3328	transposase activity
E2H98_RS15220	COG3047	cAMP biosynthetic process
E2H98_RS15235	COG3154	lipid carrier protein
E2H98_RS15240	COG0826	peptidase U32
E2H98_RS15245	COG0826	peptidase U32
E2H98_RS15250	COG1242	4 iron, 4 sulfur cluster binding
E2H98_RS15255	COG0028	Belongs to the TPP enzyme family
E2H98_RS15270	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E2H98_RS15270	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E2H98_RS15275	COG3005	denitrification pathway
E2H98_RS15280	COG3043	anaerobic respiration
E2H98_RS15285	COG0243	molybdopterin cofactor binding
E2H98_RS15295	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
E2H98_RS15295	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E2H98_RS15300	COG4459	periplasmic nitrate reductase
E2H98_RS15305	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
E2H98_RS15310	COG0303	'Molybdopterin
E2H98_RS15315	COG0746	molybdenum cofactor guanylyltransferase activity
E2H98_RS15320	COG0521	Mo-molybdopterin cofactor biosynthetic process
E2H98_RS15360	COG2902	Dehydrogenase
E2H98_RS15370	COG4152	abc transporter atp-binding protein
E2H98_RS15375	COG1574	metal-dependent hydrolase with the TIM-barrel fold
E2H98_RS15385	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
E2H98_RS15390	COG0217	transcriptional regulatory protein
E2H98_RS15395	COG3328	transposase activity
E2H98_RS15410	COG3012	SEC-C Motif Domain Protein
E2H98_RS15415	COG4106	trans-aconitate 2-methyltransferase activity
E2H98_RS15435	COG0596	Alpha beta hydrolase
E2H98_RS15445	COG4251	negative regulation of phosphorylation
E2H98_RS15445	COG3706	GGDEF domain
E2H98_RS15445	COG2203	Gaf domain
E2H98_RS15445	COG5001	Diguanylate cyclase
E2H98_RS15470	COG3228	Belongs to the MtfA family
E2H98_RS15485	COG2207	Transcriptional regulator
E2H98_RS15520	COG3001	Fructosamine kinase
E2H98_RS15540	COG2070	2-Nitropropane dioxygenase
E2H98_RS15560	COG0459	protein refolding
E2H98_RS15575	COG0456	acetyltransferase
E2H98_RS15580	COG1917	Cupin 2, conserved barrel domain protein
E2H98_RS15580	COG4977	sequence-specific DNA binding
E2H98_RS15585	COG0583	DNA-binding transcription factor activity
E2H98_RS15595	COG1335	isochorismatase
E2H98_RS15685	COG2814	Major facilitator Superfamily
E2H98_RS15740	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E2H98_RS15770	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E2H98_RS15780	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E2H98_RS15780	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E2H98_RS15790	COG0784	Response regulator, receiver
E2H98_RS15805	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
E2H98_RS15820	COG3011	Protein conserved in bacteria
E2H98_RS15835	COG0450	alkyl hydroperoxide reductase
E2H98_RS15845	COG4264	IucA IucC family
E2H98_RS15885	COG1730	sister chromatid segregation
E2H98_RS15930	COG4783	chaperone-mediated protein folding
E2H98_RS15935	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E2H98_RS15940	COG0418	dihydroorotase activity
E2H98_RS15955	COG0346	lactoylglutathione lyase activity
E2H98_RS16015	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
E2H98_RS16020	COG0632	four-way junction helicase activity
E2H98_RS16025	COG2255	four-way junction helicase activity
E2H98_RS16030	COG0824	Thioesterase
E2H98_RS16035	COG0811	peptide transport
E2H98_RS16050	COG0823	Involved in the tonB-independent uptake of proteins
E2H98_RS16055	COG2885	chlorophyll binding
E2H98_RS16060	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
E2H98_RS16065	COG0602	queuosine metabolic process
E2H98_RS16070	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
E2H98_RS16090	COG0820	rRNA (adenine-C2-)-methyltransferase activity
E2H98_RS16110	COG0124	histidyl-tRNA synthetase
E2H98_RS16115	COG2976	Protein conserved in bacteria
E2H98_RS16120	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E2H98_RS16125	COG1160	GTP binding
E2H98_RS16140	COG1570	exodeoxyribonuclease VII activity
E2H98_RS16145	COG0516	GMP reductase activity
E2H98_RS16145	COG0517	IMP dehydrogenase activity
E2H98_RS16150	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E2H98_RS16150	COG0519	Catalyzes the synthesis of GMP from XMP
E2H98_RS16170	COG5000	phosphorelay sensor kinase activity
E2H98_RS16175	COG2204	response regulator
E2H98_RS16180	COG1136	(ABC) transporter
E2H98_RS16180	COG0577	efflux transmembrane transporter activity
E2H98_RS16185	COG0577	efflux transmembrane transporter activity
E2H98_RS16190	COG1136	(ABC) transporter
E2H98_RS16200	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
E2H98_RS16225	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E2H98_RS16225	COG0047	phosphoribosylformylglycinamidine synthase activity
E2H98_RS16230	COG2918	glutathione biosynthetic process
E2H98_RS16240	COG0612	Peptidase, M16
E2H98_RS16245	COG2259	Doxx family
E2H98_RS16250	COG1741	Belongs to the pirin family
E2H98_RS16255	COG0583	DNA-binding transcription factor activity
E2H98_RS16280	COG0437	4 iron, 4 sulfur cluster binding
E2H98_RS16325	COG0183	Belongs to the thiolase family
E2H98_RS16330	COG1250	3-hydroxyacyl-CoA dehydrogenase
E2H98_RS16330	COG1024	Enoyl-CoA hydratase
E2H98_RS16340	COG3137	Salt-induced outer membrane protein
E2H98_RS16345	COG2379	hydroxypyruvate reductase
E2H98_RS16350	COG0714	Associated with various cellular activities
E2H98_RS16375	COG0067	glutamate synthase
E2H98_RS16375	COG0069	glutamate synthase activity
E2H98_RS16375	COG0070	glutamate synthase
E2H98_RS16380	COG0493	'glutamate synthase
E2H98_RS16385	COG2827	Endonuclease containing a URI domain
E2H98_RS16390	COG0579	oxidoreductase
E2H98_RS16405	COG2205	protein histidine kinase activity
E2H98_RS16410	COG0745	RESPONSE REGULATOR receiver
E2H98_RS16415	COG4181	ATPase activity
E2H98_RS16420	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
E2H98_RS16435	COG0167	dihydroorotate dehydrogenase activity
E2H98_RS16445	COG0116	Belongs to the methyltransferase superfamily
E2H98_RS16445	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
E2H98_RS16465	COG1960	acyl-CoA dehydrogenase activity
E2H98_RS16480	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
E2H98_RS16485	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
E2H98_RS16545	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E2H98_RS16555	COG0456	acetyltransferase
E2H98_RS16565	COG0084	hydrolase, TatD family'
E2H98_RS16570	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E2H98_RS16575	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E2H98_RS16630	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
E2H98_RS16640	COG0512	Glutamine amidotransferase of anthranilate synthase
E2H98_RS16645	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E2H98_RS16650	COG0135	phosphoribosylanthranilate isomerase activity
E2H98_RS16650	COG0134	indole-3-glycerol-phosphate synthase activity
E2H98_RS16670	COG0456	acetyltransferase
E2H98_RS16680	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
E2H98_RS16690	COG0107	imidazoleglycerol-phosphate synthase activity
E2H98_RS16695	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
E2H98_RS16700	COG0131	Imidazoleglycerol-phosphate dehydratase
E2H98_RS16705	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E2H98_RS16710	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
E2H98_RS16715	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E2H98_RS16720	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
E2H98_RS16740	COG1393	Belongs to the ArsC family
E2H98_RS16745	COG1295	ribonuclease BN
E2H98_RS16800	COG1477	protein flavinylation
E2H98_RS16835	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E2H98_RS16850	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
E2H98_RS16850	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E2H98_RS16860	COG2207	Transcriptional regulator
E2H98_RS16860	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E2H98_RS16870	COG3291	Pkd domain containing protein
E2H98_RS16900	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E2H98_RS16910	COG2205	protein histidine kinase activity
E2H98_RS16910	COG2198	Histidine kinase
E2H98_RS16910	COG0784	Response regulator, receiver
E2H98_RS16915	COG0457	Tetratricopeptide repeat
E2H98_RS16925	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E2H98_RS16935	COG3340	Belongs to the peptidase S51 family
E2H98_RS16945	COG0432	Pfam Uncharacterised protein family UPF0047
E2H98_RS16950	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E2H98_RS16965	COG0674	pyruvate-flavodoxin oxidoreductase activity
E2H98_RS16965	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
E2H98_RS16970	COG1013	pyruvate-flavodoxin oxidoreductase activity
E2H98_RS16980	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
E2H98_RS16985	COG0336	Belongs to the RNA methyltransferase TrmD family
E2H98_RS16995	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E2H98_RS17005	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E2H98_RS17020	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E2H98_RS17030	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
E2H98_RS17045	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
E2H98_RS17070	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E2H98_RS17100	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E2H98_RS17105	COG0481	GTPase activity
E2H98_RS17120	COG0571	ribonuclease III activity
E2H98_RS17130	COG1381	Involved in DNA repair and RecF pathway recombination
E2H98_RS17135	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
E2H98_RS17140	COG0736	holo-[acyl-carrier-protein] synthase activity
E2H98_RS17155	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E2H98_RS17165	COG0071	Belongs to the small heat shock protein (HSP20) family
E2H98_RS17170	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
E2H98_RS17175	COG1028	Short-chain dehydrogenase reductase Sdr
E2H98_RS17185	COG0386	Belongs to the glutathione peroxidase family
E2H98_RS17195	COG1024	Enoyl-CoA hydratase
E2H98_RS17220	COG1028	Short-chain dehydrogenase reductase Sdr
E2H98_RS17230	COG0676	glucose-6-phosphate 1-epimerase activity
E2H98_RS17235	COG0546	phosphoglycolate phosphatase activity
E2H98_RS17245	COG0402	S-adenosylhomocysteine deaminase activity
E2H98_RS17270	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E2H98_RS17275	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
E2H98_RS17280	COG0539	negative regulation of cytoplasmic translation
E2H98_RS17285	COG0776	regulation of translation
E2H98_RS17295	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
E2H98_RS17300	COG0284	orotidine-5'-phosphate decarboxylase activity
E2H98_RS17305	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
E2H98_RS17310	COG4095	Psort location CytoplasmicMembrane, score
E2H98_RS17315	COG1555	photosystem II stabilization
E2H98_RS17360	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E2H98_RS17370	COG1088	dTDP-glucose 4,6-dehydratase activity
E2H98_RS17375	COG0579	oxidoreductase
E2H98_RS17390	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E2H98_RS17410	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
E2H98_RS17430	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E2H98_RS17445	COG0436	Aminotransferase
E2H98_RS17450	COG0556	nucleotide-excision repair
E2H98_RS17470	COG1496	oxidoreductase activity
E2H98_RS17480	COG0542	response to heat
E2H98_RS17500	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E2H98_RS17505	COG1396	sequence-specific DNA binding
E2H98_RS17505	COG1917	Cupin 2, conserved barrel domain protein
E2H98_RS17510	COG1012	belongs to the aldehyde dehydrogenase family
E2H98_RS17525	COG0010	Belongs to the arginase family
E2H98_RS17530	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E2H98_RS17535	COG0174	glutamine synthetase
E2H98_RS17540	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
E2H98_RS17555	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
E2H98_RS17560	COG3842	ATPase activity
E2H98_RS17565	COG1176	ABC-type spermidine putrescine transport system, permease component I
E2H98_RS17570	COG1177	transmembrane transport
E2H98_RS17605	COG1132	(ABC) transporter
E2H98_RS17615	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E2H98_RS17640	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E2H98_RS17645	COG0795	lipopolysaccharide-transporting ATPase activity
E2H98_RS17650	COG0795	lipopolysaccharide-transporting ATPase activity
E2H98_RS17680	COG0306	phosphate transporter
E2H98_RS17685	COG1392	Phosphate transport regulator
E2H98_RS17700	COG0521	Mo-molybdopterin cofactor biosynthetic process
E2H98_RS17705	COG4133	protoheme IX ABC transporter activity
E2H98_RS17720	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E2H98_RS17725	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
E2H98_RS17755	COG3220	belongs to the UPF0276 family
E2H98_RS17765	COG2853	Lipoprotein
E2H98_RS17775	COG0745	RESPONSE REGULATOR receiver
E2H98_RS17790	COG2205	protein histidine kinase activity
E2H98_RS17805	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
E2H98_RS17810	COG2137	regulation of response to DNA damage stimulus
E2H98_RS17815	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E2H98_RS17820	COG0527	aspartate kinase activity
E2H98_RS17825	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
E2H98_RS17870	COG0778	Nitroreductase
E2H98_RS17885	COG0017	Asparaginyl-tRNA synthetase
E2H98_RS17895	COG5001	Diguanylate cyclase
E2H98_RS17895	COG5002	protein histidine kinase activity
E2H98_RS17900	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E2H98_RS17910	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E2H98_RS17915	COG1956	GAF domain-containing protein
E2H98_RS17930	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E2H98_RS17935	COG3267	Type II secretory pathway component ExeA
E2H98_RS17935	COG3409	Peptidoglycan-binding domain 1 protein
E2H98_RS17940	COG1960	acyl-CoA dehydrogenase activity
E2H98_RS17965	COG1643	Atp-dependent helicase
E2H98_RS17985	COG1196	nuclear chromosome segregation
E2H98_RS17990	COG3115	cell septum assembly
E2H98_RS17995	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E2H98_RS18030	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
E2H98_RS18035	COG0066	3-isopropylmalate dehydratase activity
E2H98_RS18040	COG0473	3-isopropylmalate dehydrogenase activity
E2H98_RS18055	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E2H98_RS18060	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E2H98_RS18065	COG0424	maF-like protein
E2H98_RS18070	COG1399	metal-binding, possibly nucleic acid-binding protein
E2H98_RS18075	COG0333	Belongs to the bacterial ribosomal protein bL32 family
E2H98_RS18080	COG0416	fatty acid biosynthetic process
E2H98_RS18085	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E2H98_RS18095	COG1028	Short-chain dehydrogenase reductase Sdr
E2H98_RS18100	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E2H98_RS18105	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E2H98_RS18110	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E2H98_RS18115	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E2H98_RS18120	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E2H98_RS18135	COG0084	hydrolase, TatD family'
E2H98_RS18140	COG1960	acyl-CoA dehydrogenase activity
E2H98_RS18155	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E2H98_RS18175	COG0347	Belongs to the P(II) protein family
E2H98_RS18180	COG4783	chaperone-mediated protein folding
E2H98_RS18185	COG0425	Belongs to the sulfur carrier protein TusA family
E2H98_RS18190	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
E2H98_RS18195	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E2H98_RS18205	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E2H98_RS18215	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
E2H98_RS18220	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E2H98_RS18235	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E2H98_RS18240	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
E2H98_RS18260	COG0628	permease
E2H98_RS18275	COG0527	aspartate kinase activity
E2H98_RS18285	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E2H98_RS18300	COG0101	tRNA pseudouridine synthase activity
E2H98_RS18305	COG2832	Protein of unknown function (DUF454)
E2H98_RS18320	COG4990	cell redox homeostasis
E2H98_RS18320	COG3591	Belongs to the peptidase S1B family
E2H98_RS18325	COG0154	amidase activity
E2H98_RS18330	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
E2H98_RS18335	COG0534	Mate efflux family protein
E2H98_RS18355	COG2850	peptidyl-arginine hydroxylation
E2H98_RS18365	COG0564	pseudouridine synthase activity
E2H98_RS18370	COG0513	Belongs to the DEAD box helicase family
E2H98_RS18415	COG0358	DNA primase activity
E2H98_RS18420	COG4974	Belongs to the 'phage' integrase family
E2H98_RS18430	COG3209	COG3209 Rhs family protein
E2H98_RS18500	COG1472	Belongs to the glycosyl hydrolase 3 family
E2H98_RS18515	COG2211	Major facilitator Superfamily
E2H98_RS18520	COG1609	Transcriptional regulator
E2H98_RS18565	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E2H98_RS18580	COG4206	TonB-dependent receptor
E2H98_RS18595	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E2H98_RS18600	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
E2H98_RS18615	COG0586	Pfam SNARE associated Golgi protein
E2H98_RS18635	COG0626	cystathionine gamma-synthase activity
E2H98_RS18640	COG0527	aspartate kinase activity
E2H98_RS18640	COG0460	homoserine dehydrogenase
E2H98_RS18645	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E2H98_RS18655	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
E2H98_RS18665	COG1404	Belongs to the peptidase S8 family
E2H98_RS18690	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
E2H98_RS18695	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E2H98_RS18700	COG0326	Molecular chaperone. Has ATPase activity
E2H98_RS18710	COG0563	adenylate kinase activity
E2H98_RS18715	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
E2H98_RS18730	COG0733	neurotransmitter:sodium symporter activity
E2H98_RS18745	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E2H98_RS18780	COG1028	Short-chain dehydrogenase reductase Sdr
E2H98_RS18795	COG0784	Response regulator, receiver
E2H98_RS18795	COG2198	Histidine kinase
E2H98_RS18795	COG2205	protein histidine kinase activity
E2H98_RS18800	COG2610	gluconate transmembrane transporter activity
E2H98_RS18805	COG4771	TonB-dependent receptor
E2H98_RS18820	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E2H98_RS18825	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
E2H98_RS18845	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E2H98_RS18850	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
E2H98_RS18860	COG4770	biotin carboxylase activity
E2H98_RS18865	COG1024	Enoyl-CoA hydratase
E2H98_RS18870	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E2H98_RS18875	COG1960	acyl-CoA dehydrogenase activity
E2H98_RS18880	COG0183	Belongs to the thiolase family
E2H98_RS18885	COG1960	acyl-CoA dehydrogenase activity
E2H98_RS18895	COG3130	regulation of translation
E2H98_RS18910	COG0322	excinuclease ABC activity
E2H98_RS18945	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E2H98_RS18950	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E2H98_RS18965	COG2217	Heavy metal translocating P-type atpase
E2H98_RS18980	COG2010	Cytochrome c
E2H98_RS18995	COG3278	Belongs to the heme-copper respiratory oxidase family
E2H98_RS19005	COG3588	fructose-bisphosphate aldolase
E2H98_RS19010	COG0783	Belongs to the Dps family
E2H98_RS19015	COG2204	response regulator
E2H98_RS19070	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
E2H98_RS19095	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E2H98_RS19100	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E2H98_RS19110	COG0427	acetyl-CoA hydrolase