locus-tag	class	description
D1822_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D1822_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
D1822_RS00030	COG0431	NADPH-dependent FMN reductase
D1822_RS00100	COG1846	Transcriptional regulator
D1822_RS00130	COG0582	viral genome integration into host DNA
D1822_RS00160	COG0587	DNA-directed DNA polymerase activity
D1822_RS00175	COG3046	protein related to deoxyribodipyrimidine photolyase
D1822_RS00180	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D1822_RS00190	COG0625	glutathione transferase activity
D1822_RS00215	COG0179	Fumarylacetoacetate (FAA) hydrolase
D1822_RS00220	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
D1822_RS00245	COG0489	protein tyrosine kinase activity
D1822_RS00245	COG2151	metal-sulfur cluster biosynthetic enzyme
D1822_RS00250	COG0254	rRNA binding
D1822_RS00255	COG0335	large ribosomal subunit rRNA binding
D1822_RS00260	COG0336	Belongs to the RNA methyltransferase TrmD family
D1822_RS00270	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
D1822_RS00275	COG0778	Nitroreductase
D1822_RS00280	COG0228	four-way junction DNA binding
D1822_RS00295	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D1822_RS00305	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D1822_RS00310	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D1822_RS00345	COG0356	it plays a direct role in the translocation of protons across the membrane
D1822_RS00350	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D1822_RS00355	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D1822_RS00360	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D1822_RS00370	COG2186	Transcriptional regulator
D1822_RS00400	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
D1822_RS00410	COG0435	Glutathione S-transferase
D1822_RS00420	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
D1822_RS00425	COG0242	peptide deformylase activity
D1822_RS00430	COG0242	peptide deformylase activity
D1822_RS00435	COG0242	peptide deformylase activity
D1822_RS00440	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D1822_RS00450	COG2860	membrane
D1822_RS00455	COG0328	RNA-DNA hybrid ribonuclease activity
D1822_RS00475	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
D1822_RS00485	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D1822_RS00490	COG1758	RNA polymerase activity
D1822_RS00505	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
D1822_RS00510	COG0736	holo-[acyl-carrier-protein] synthase activity
D1822_RS00515	COG0681	Belongs to the peptidase S26 family
D1822_RS00520	COG0571	ribonuclease III activity
D1822_RS00525	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
D1822_RS00535	COG1381	Involved in DNA repair and RecF pathway recombination
D1822_RS00555	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
D1822_RS00560	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
D1822_RS00565	COG0745	RESPONSE REGULATOR receiver
D1822_RS00570	COG2205	protein histidine kinase activity
D1822_RS00575	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
D1822_RS00580	COG1660	Displays ATPase and GTPase activities
D1822_RS00590	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D1822_RS00600	COG1250	3-hydroxyacyl-CoA dehydrogenase
D1822_RS00620	COG2096	Adenosyltransferase
D1822_RS00630	COG0300	oxidoreductase activity
D1822_RS00640	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D1822_RS00650	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D1822_RS00675	COG0250	Participates in transcription elongation, termination and antitermination
D1822_RS00685	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
D1822_RS00690	COG0081	regulation of translation
D1822_RS00695	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D1822_RS00700	COG0222	ribosome binding
D1822_RS00705	COG0085	RNA polymerase activity
D1822_RS00710	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
D1822_RS00730	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
D1822_RS00735	COG0049	tRNA binding
D1822_RS00740	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D1822_RS00745	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D1822_RS00755	COG0051	transcription antitermination factor activity, RNA binding
D1822_RS00760	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
D1822_RS00765	COG0088	Forms part of the polypeptide exit tunnel
D1822_RS00770	COG0089	rRNA binding
D1822_RS00780	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
D1822_RS00785	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
D1822_RS00790	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
D1822_RS00795	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
D1822_RS00800	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
D1822_RS00825	COG0255	Belongs to the universal ribosomal protein uL29 family
D1822_RS00830	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
D1822_RS00835	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
D1822_RS00840	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
D1822_RS00845	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
D1822_RS00850	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D1822_RS00855	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
D1822_RS00860	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
D1822_RS00865	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
D1822_RS00870	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
D1822_RS00875	COG1841	ribosomal large subunit assembly
D1822_RS00890	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D1822_RS00910	COG0200	Binds to the 23S rRNA
D1822_RS00915	COG0201	protein transport
D1822_RS00920	COG0563	adenylate kinase activity
D1822_RS00925	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
D1822_RS00930	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
D1822_RS00935	COG0202	RNA polymerase activity
D1822_RS00940	COG0203	ribosomal protein L17
D1822_RS00945	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D1822_RS00950	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D1822_RS00955	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D1822_RS00965	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D1822_RS00975	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D1822_RS00980	COG4597	amino acid ABC transporter
D1822_RS00985	COG0765	amino acid transport
D1822_RS00990	COG1126	abc transporter atp-binding protein
D1822_RS01010	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D1822_RS01015	COG1028	Short-chain dehydrogenase reductase Sdr
D1822_RS01020	COG0218	Necessary for normal cell division and for the maintenance of normal septation
D1822_RS01030	COG0706	membrane insertase activity
D1822_RS01040	COG0037	tRNA processing
D1822_RS01050	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
D1822_RS01055	COG0594	ribonuclease P activity
D1822_RS01060	COG0230	Belongs to the bacterial ribosomal protein bL34 family
D1822_RS01075	COG4191	Histidine kinase
D1822_RS01130	COG0668	transmembrane transport
D1822_RS01135	COG2116	formate transmembrane transporter activity
D1822_RS01160	COG0789	Transcriptional regulator
D1822_RS01165	COG2814	Major facilitator Superfamily
D1822_RS01170	COG3591	Belongs to the peptidase S1B family
D1822_RS01175	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D1822_RS01195	COG2766	serine protein kinase
D1822_RS01200	COG2718	Belongs to the UPF0229 family
D1822_RS01205	COG2719	SpoVR family
D1822_RS01210	COG1802	Transcriptional regulator
D1822_RS01215	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
D1822_RS01235	COG3485	protocatechuate 3,4-dioxygenase
D1822_RS01240	COG3485	protocatechuate 3,4-dioxygenase
D1822_RS01245	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D1822_RS01250	COG0583	DNA-binding transcription factor activity
D1822_RS01260	COG4214	carbohydrate transport
D1822_RS01275	COG1022	Amp-dependent synthetase and ligase
D1822_RS01295	COG0604	alcohol dehydrogenase
D1822_RS01310	COG1609	Transcriptional regulator
D1822_RS01315	COG1653	transport
D1822_RS01325	COG0395	ABC-type sugar transport system, permease component
D1822_RS01330	COG3842	ATPase activity
D1822_RS01340	COG2169	Transcriptional regulator
D1822_RS01340	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D1822_RS01345	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
D1822_RS01355	COG0793	Belongs to the peptidase S41A family
D1822_RS01375	COG1131	(ABC) transporter
D1822_RS01380	COG0842	Transport permease protein
D1822_RS01400	COG1028	Short-chain dehydrogenase reductase Sdr
D1822_RS01405	COG0322	excinuclease ABC activity
D1822_RS01410	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D1822_RS01420	COG0314	molybdopterin synthase activity
D1822_RS01430	COG2885	chlorophyll binding
D1822_RS01440	COG1385	rRNA (uridine-N3-)-methyltransferase activity
D1822_RS01470	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
D1822_RS01495	COG0540	Belongs to the ATCase OTCase family
D1822_RS01500	COG1573	uracil-dna glycosylase
D1822_RS01505	COG0521	Mo-molybdopterin cofactor biosynthetic process
D1822_RS01515	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D1822_RS01520	COG0494	nUDIX hydrolase
D1822_RS01530	COG1678	Uncharacterized ACR, COG1678
D1822_RS01535	COG0009	L-threonylcarbamoyladenylate synthase
D1822_RS01540	COG1960	acyl-CoA dehydrogenase activity
D1822_RS01580	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
D1822_RS01585	COG0746	molybdenum cofactor guanylyltransferase activity
D1822_RS01590	COG1763	Mo-molybdopterin cofactor biosynthetic process
D1822_RS01600	COG0303	'Molybdopterin
D1822_RS01610	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D1822_RS01620	COG0789	Transcriptional regulator
D1822_RS01635	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
D1822_RS01640	COG0142	geranyltranstransferase activity
D1822_RS01665	COG0583	DNA-binding transcription factor activity
D1822_RS01670	COG1028	Short-chain dehydrogenase reductase Sdr
D1822_RS01695	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D1822_RS01700	COG0165	Argininosuccinate lyase
D1822_RS01710	COG0019	diaminopimelate decarboxylase activity
D1822_RS01725	COG2884	Cell division ATP-binding protein ftsE
D1822_RS01770	COG0508	dehydrogenase complex catalyzes the overall conversion of
D1822_RS01790	COG0045	succinate-CoA ligase (ADP-forming) activity
D1822_RS01800	COG0039	L-malate dehydrogenase activity
D1822_RS01830	COG2030	dehydratase
D1822_RS01880	COG0019	diaminopimelate decarboxylase activity
D1822_RS01890	COG0813	purine-nucleoside phosphorylase activity
D1822_RS01900	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D1822_RS01900	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D1822_RS01915	COG0604	alcohol dehydrogenase
D1822_RS01935	COG1028	Short-chain dehydrogenase reductase Sdr
D1822_RS01945	COG0730	response to heat
D1822_RS01950	COG1079	Belongs to the binding-protein-dependent transport system permease family
D1822_RS01955	COG4603	Belongs to the binding-protein-dependent transport system permease family
D1822_RS01960	COG3845	ABC transporter
D1822_RS01965	COG1744	ABC transporter substrate-binding protein PnrA-like
D1822_RS01975	COG1214	PFAM Peptidase M22, glycoprotease
D1822_RS01980	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
D1822_RS02000	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D1822_RS02005	COG2151	metal-sulfur cluster biosynthetic enzyme
D1822_RS02010	COG3396	Phenylacetate-CoA oxygenase
D1822_RS02015	COG3460	Phenylacetate-CoA oxygenase
D1822_RS02020	COG3396	Phenylacetate-CoA oxygenase
D1822_RS02035	COG1250	3-hydroxyacyl-CoA dehydrogenase
D1822_RS02035	COG1024	Enoyl-CoA hydratase
D1822_RS02040	COG0183	Belongs to the thiolase family
D1822_RS02045	COG1960	acyl-CoA dehydrogenase activity
D1822_RS02050	COG1960	acyl-CoA dehydrogenase activity
D1822_RS02060	COG0318	PFAM AMP-dependent synthetase and ligase
D1822_RS02070	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
D1822_RS02075	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
D1822_RS02080	COG3639	organic phosphonate transmembrane transporter activity
D1822_RS02085	COG3639	organic phosphonate transmembrane transporter activity
D1822_RS02090	COG0110	maltose O-acetyltransferase activity
D1822_RS02095	COG2188	Transcriptional regulator
D1822_RS02100	COG3624	Phosphonate C-P lyase system protein PhnG
D1822_RS02110	COG3626	phosphonate metabolism
D1822_RS02120	COG3627	carbon phosphorus lyase activity
D1822_RS02125	COG4107	phosphonate C-P lyase system protein PhnK
D1822_RS02130	COG4778	phosphonate C-P lyase system protein PhnL
D1822_RS02145	COG3454	Phosphonate metabolism
D1822_RS02165	COG0588	phosphoglycerate mutase activity
D1822_RS02170	COG0438	transferase activity, transferring glycosyl groups
D1822_RS02185	COG0668	transmembrane transport
D1822_RS02190	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D1822_RS02195	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D1822_RS02200	COG0601	transmembrane transport
D1822_RS02235	COG1522	sequence-specific DNA binding
D1822_RS02245	COG1132	(ABC) transporter
D1822_RS02255	COG4948	Mandelate Racemase Muconate Lactonizing
D1822_RS02270	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D1822_RS02295	COG1047	Peptidyl-prolyl cis-trans
D1822_RS02300	COG2070	2-Nitropropane dioxygenase
D1822_RS02305	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D1822_RS02310	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D1822_RS02315	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D1822_RS02325	COG0583	DNA-binding transcription factor activity
D1822_RS02340	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D1822_RS02355	COG1702	phosphate starvation-inducible protein PhoH
D1822_RS02360	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
D1822_RS02365	COG1253	flavin adenine dinucleotide binding
D1822_RS02370	COG0815	Transfers the fatty acyl group on membrane lipoproteins
D1822_RS02375	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
D1822_RS02385	COG0220	tRNA (guanine-N7-)-methyltransferase activity
D1822_RS02390	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
D1822_RS02395	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
D1822_RS02400	COG0539	negative regulation of cytoplasmic translation
D1822_RS02405	COG0776	regulation of translation
D1822_RS02415	COG0135	phosphoribosylanthranilate isomerase activity
D1822_RS02420	COG0133	tryptophan synthase activity
D1822_RS02435	COG0193	aminoacyl-tRNA hydrolase activity
D1822_RS02440	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
D1822_RS02450	COG0159	tryptophan synthase activity
D1822_RS02460	COG0012	GTP binding
D1822_RS02490	COG4638	Rieske (2fe-2S)
D1822_RS02545	COG1012	belongs to the aldehyde dehydrogenase family
D1822_RS02550	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D1822_RS02555	COG0840	transmembrane signaling receptor activity
D1822_RS02575	COG0395	ABC-type sugar transport system, permease component
D1822_RS02580	COG1175	transmembrane transport
D1822_RS02585	COG3842	ATPase activity
D1822_RS02590	COG3842	ATPase activity
D1822_RS02600	COG0116	Belongs to the methyltransferase superfamily
D1822_RS02600	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
D1822_RS02625	COG2244	polysaccharide biosynthetic process
D1822_RS02630	COG0438	transferase activity, transferring glycosyl groups
D1822_RS02675	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
D1822_RS02690	COG0837	glucose binding
D1822_RS02715	COG2351	hydroxyisourate hydrolase activity
D1822_RS02725	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
D1822_RS02745	COG3257	ureidoglycine aminohydrolase activity
D1822_RS02765	COG0509	glycine decarboxylation via glycine cleavage system
D1822_RS02780	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
D1822_RS02785	COG0720	synthase
D1822_RS02790	COG0602	queuosine metabolic process
D1822_RS02795	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
D1822_RS02805	COG0101	tRNA pseudouridine synthase activity
D1822_RS02810	COG3106	COG3106 Predicted ATPase
D1822_RS02820	COG3768	UPF0283 membrane protein
D1822_RS02835	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
D1822_RS02845	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D1822_RS02850	COG1183	phosphatidylcholine synthase activity
D1822_RS02860	COG4974	Belongs to the 'phage' integrase family
D1822_RS02870	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D1822_RS02880	COG2391	methyltransferase activity
D1822_RS02890	COG2264	protein methyltransferase activity
D1822_RS02905	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
D1822_RS02910	COG0632	four-way junction helicase activity
D1822_RS02915	COG2255	four-way junction helicase activity
D1822_RS02925	COG0824	Thioesterase
D1822_RS02945	COG0823	Involved in the tonB-independent uptake of proteins
D1822_RS02950	COG2885	chlorophyll binding
D1822_RS02960	COG0037	tRNA processing
D1822_RS02965	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D1822_RS02975	COG2759	Belongs to the formate--tetrahydrofolate ligase family
D1822_RS02980	COG1605	Chorismate mutase
D1822_RS02980	COG0287	Prephenate dehydrogenase
D1822_RS02985	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
D1822_RS03000	COG1201	RNA secondary structure unwinding
D1822_RS03045	COG2885	chlorophyll binding
D1822_RS03050	COG4964	Belongs to the GSP D family
D1822_RS03065	COG0741	lytic transglycosylase activity
D1822_RS03085	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D1822_RS03090	COG0758	DNA mediated transformation
D1822_RS03095	COG0312	modulator of DNA gyrase
D1822_RS03105	COG0109	protoheme IX farnesyltransferase activity
D1822_RS03115	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
D1822_RS03135	COG0612	Peptidase, M16
D1822_RS03150	COG2271	Major facilitator Superfamily
D1822_RS03155	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
D1822_RS03160	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D1822_RS03165	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
D1822_RS03170	COG0659	secondary active sulfate transmembrane transporter activity
D1822_RS03180	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D1822_RS03210	COG0752	glycyl-tRNA synthetase alpha subunit
D1822_RS03220	COG0786	glutamate:sodium symporter activity
D1822_RS03225	COG0751	glycine-tRNA ligase activity
D1822_RS03230	COG0574	Belongs to the PEP-utilizing enzyme family
D1822_RS03230	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D1822_RS03240	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
D1822_RS03245	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
D1822_RS03250	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D1822_RS03265	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
D1822_RS03275	COG1522	sequence-specific DNA binding
D1822_RS03300	COG1802	Transcriptional regulator
D1822_RS03310	COG0505	Belongs to the CarA family
D1822_RS03335	COG0537	adenosine 5'-monophosphoramidase activity
D1822_RS03345	COG0321	lipoyl(octanoyl) transferase activity
D1822_RS03370	COG0601	transmembrane transport
D1822_RS03375	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D1822_RS03380	COG0444	Belongs to the ABC transporter superfamily
D1822_RS03385	COG4608	Belongs to the ABC transporter superfamily
D1822_RS03390	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
D1822_RS03450	COG0469	pyruvate kinase activity
D1822_RS03460	COG0291	Belongs to the bacterial ribosomal protein bL35 family
D1822_RS03465	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
D1822_RS03470	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
D1822_RS03480	COG0072	phenylalanine-tRNA ligase activity
D1822_RS03480	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D1822_RS03505	COG0668	transmembrane transport
D1822_RS03510	COG1970	mechanosensitive ion channel activity
D1822_RS03520	COG1115	amino acid carrier protein
D1822_RS03535	COG1858	cytochrome C peroxidase
D1822_RS03545	COG3391	amine dehydrogenase activity
D1822_RS03570	COG0673	inositol 2-dehydrogenase activity
D1822_RS03585	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D1822_RS03590	COG3962	Belongs to the TPP enzyme family
D1822_RS03595	COG0673	inositol 2-dehydrogenase activity
D1822_RS03605	COG0673	inositol 2-dehydrogenase activity
D1822_RS03620	COG4214	carbohydrate transport
D1822_RS03640	COG0800	Aldolase
D1822_RS03650	COG1028	Short-chain dehydrogenase reductase Sdr
D1822_RS03655	COG0129	dihydroxy-acid dehydratase activity
D1822_RS03665	COG0395	ABC-type sugar transport system, permease component
D1822_RS03670	COG1175	transmembrane transport
D1822_RS03700	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D1822_RS03730	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
D1822_RS03735	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
D1822_RS03740	COG1329	Transcriptional regulator
D1822_RS03750	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
D1822_RS03755	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
D1822_RS03790	COG2873	o-acetylhomoserine
D1822_RS03810	COG3916	Acyl-homoserine-lactone synthase
D1822_RS03840	COG1028	Short-chain dehydrogenase reductase Sdr
D1822_RS03845	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
D1822_RS03850	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D1822_RS03850	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D1822_RS03855	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D1822_RS03875	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D1822_RS03880	COG0006	proline dipeptidase activity
D1822_RS03890	COG2723	6-phospho-beta-galactosidase activity
D1822_RS03895	COG1609	Transcriptional regulator
D1822_RS03900	COG1653	transport
D1822_RS03905	COG1175	transmembrane transport
D1822_RS03910	COG0395	ABC-type sugar transport system, permease component
D1822_RS03915	COG0366	Alpha amylase catalytic
D1822_RS03920	COG3842	ATPase activity
D1822_RS03960	COG1234	tRNA 3'-trailer cleavage
D1822_RS03965	COG0084	hydrolase, TatD family'
D1822_RS03975	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D1822_RS03980	COG1686	Belongs to the peptidase S11 family
D1822_RS04005	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D1822_RS04005	COG1648	precorrin-2 dehydrogenase activity
D1822_RS04010	COG1797	cobyrinic acid a,c-diamide synthase activity
D1822_RS04015	COG2875	Belongs to the precorrin methyltransferase family
D1822_RS04030	COG2099	Precorrin-6x reductase
D1822_RS04130	COG0583	DNA-binding transcription factor activity
D1822_RS04140	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D1822_RS04160	COG0667	Aldo Keto reductase
D1822_RS04170	COG3246	L-lysine catabolic process to acetate
D1822_RS04180	COG1250	3-hydroxyacyl-CoA dehydrogenase
D1822_RS04180	COG0824	Thioesterase
D1822_RS04185	COG1028	Short-chain dehydrogenase reductase Sdr
D1822_RS04225	COG1595	DNA-templated transcription, initiation
D1822_RS04240	COG3706	GGDEF domain
D1822_RS04260	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
D1822_RS04285	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
D1822_RS04310	COG1741	Belongs to the pirin family
D1822_RS04335	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D1822_RS04340	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D1822_RS04350	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D1822_RS04350	COG0446	pyridine nucleotide-disulphide oxidoreductase
D1822_RS04365	COG0358	DNA primase activity
D1822_RS04370	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D1822_RS04380	COG4221	oxidoreductase activity
D1822_RS04395	COG0432	Pfam Uncharacterised protein family UPF0047
D1822_RS04400	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D1822_RS04405	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D1822_RS04405	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D1822_RS04435	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
D1822_RS04440	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D1822_RS04470	COG0564	pseudouridine synthase activity
D1822_RS04480	COG0840	transmembrane signaling receptor activity
D1822_RS04485	COG0351	phosphomethylpyrimidine kinase
D1822_RS04490	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D1822_RS04515	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
D1822_RS04520	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
D1822_RS04530	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
D1822_RS04545	COG4106	trans-aconitate 2-methyltransferase activity
D1822_RS04550	COG1618	nucleotide phosphatase activity, acting on free nucleotides
D1822_RS04550	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
D1822_RS04555	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D1822_RS04565	COG1832	CoA-binding protein
D1822_RS04570	COG0140	phosphoribosyl-ATP diphosphatase activity
D1822_RS04575	COG0107	imidazoleglycerol-phosphate synthase activity
D1822_RS04590	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
D1822_RS04615	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
D1822_RS04620	COG0131	Imidazoleglycerol-phosphate dehydratase
D1822_RS04630	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D1822_RS04665	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
D1822_RS04670	COG1304	FMN binding
D1822_RS04680	COG0210	DNA helicase
D1822_RS04690	COG0489	protein tyrosine kinase activity
D1822_RS04695	COG2001	Belongs to the MraZ family
D1822_RS04700	COG0275	rRNA processing
D1822_RS04715	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D1822_RS04725	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D1822_RS04730	COG2066	Belongs to the glutaminase family
D1822_RS04735	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
D1822_RS04740	COG1846	Transcriptional regulator
D1822_RS04750	COG2081	HI0933 family
D1822_RS04760	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D1822_RS04765	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D1822_RS04780	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D1822_RS04785	COG1181	Belongs to the D-alanine--D-alanine ligase family
D1822_RS04790	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
D1822_RS04795	COG0849	cell division
D1822_RS04800	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
D1822_RS04810	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D1822_RS04835	COG0006	proline dipeptidase activity
D1822_RS04880	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D1822_RS04885	COG2183	response to ionizing radiation
D1822_RS04900	COG0308	aminopeptidase N
D1822_RS04910	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
D1822_RS04920	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
D1822_RS04925	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D1822_RS04925	COG2010	Cytochrome c
D1822_RS04935	COG1309	transcriptional regulator
D1822_RS04940	COG3483	tryptophan 2,3-dioxygenase activity
D1822_RS04955	COG1028	Short-chain dehydrogenase reductase Sdr
D1822_RS04975	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
D1822_RS05000	COG2391	methyltransferase activity
D1822_RS05005	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D1822_RS05010	COG0601	transmembrane transport
D1822_RS05020	COG4172	Belongs to the ABC transporter superfamily
D1822_RS05030	COG1473	amidohydrolase
D1822_RS05035	COG1473	amidohydrolase
D1822_RS05040	COG1473	amidohydrolase
D1822_RS05050	COG1519	Transferase
D1822_RS05055	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D1822_RS05075	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
D1822_RS05095	COG1960	acyl-CoA dehydrogenase activity
D1822_RS05100	COG3047	cAMP biosynthetic process
D1822_RS05105	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D1822_RS05115	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D1822_RS05120	COG4770	biotin carboxylase activity
D1822_RS05135	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
D1822_RS05145	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D1822_RS05150	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D1822_RS05155	COG0649	NAD binding
D1822_RS05195	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
D1822_RS05200	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D1822_RS05215	COG0713	ATP synthesis coupled electron transport
D1822_RS05240	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
D1822_RS05250	COG0513	Belongs to the DEAD box helicase family
D1822_RS05265	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
D1822_RS05280	COG1028	Short-chain dehydrogenase reductase Sdr
D1822_RS05285	COG4335	DNA alkylation repair
D1822_RS05290	COG3842	ATPase activity
D1822_RS05305	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D1822_RS05310	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D1822_RS05315	COG0805	protein transport
D1822_RS05320	COG0698	ribose 5-phosphate isomerase
D1822_RS05335	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D1822_RS05340	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
D1822_RS05345	COG4221	oxidoreductase activity
D1822_RS05360	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
D1822_RS05390	COG1127	ABC transporter
D1822_RS05395	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D1822_RS05400	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D1822_RS05405	COG0305	Participates in initiation and elongation during chromosome replication
D1822_RS05410	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D1822_RS05415	COG0418	dihydroorotase activity
D1822_RS05445	COG1162	GTPase activity
D1822_RS05475	COG0542	response to heat
D1822_RS05485	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D1822_RS05490	COG1278	Cold shock
D1822_RS05515	COG0316	Belongs to the HesB IscA family
D1822_RS05520	COG0232	Belongs to the dGTPase family. Type 2 subfamily
D1822_RS05530	COG0018	arginyl-trna synthetase
D1822_RS05550	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
D1822_RS05560	COG0717	Belongs to the dCTP deaminase family
D1822_RS05575	COG0776	regulation of translation
D1822_RS05580	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D1822_RS05585	COG0416	fatty acid biosynthetic process
D1822_RS05590	COG0333	Belongs to the bacterial ribosomal protein bL32 family
D1822_RS05610	COG0488	(ABC) transporter
D1822_RS05635	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D1822_RS05640	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
D1822_RS05650	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
D1822_RS05665	COG0513	Belongs to the DEAD box helicase family
D1822_RS05675	COG0697	spore germination
D1822_RS05680	COG0148	phosphopyruvate hydratase activity
D1822_RS05705	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
D1822_RS05705	COG0456	acetyltransferase
D1822_RS05710	COG1957	nucleoside hydrolase
D1822_RS05715	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D1822_RS05720	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D1822_RS05725	COG0174	glutamine synthetase
D1822_RS05730	COG0519	Catalyzes the synthesis of GMP from XMP
D1822_RS05730	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D1822_RS05735	COG0174	glutamine synthetase
D1822_RS05745	COG4215	(ABC) transporter
D1822_RS05780	COG0525	valine-tRNA ligase activity
D1822_RS05820	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
D1822_RS05825	COG0583	DNA-binding transcription factor activity
D1822_RS05830	COG0483	inositol monophosphate 1-phosphatase activity
D1822_RS05850	COG1522	sequence-specific DNA binding
D1822_RS05905	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D1822_RS05910	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
D1822_RS05915	COG0154	amidase activity
D1822_RS05930	COG0281	malic enzyme
D1822_RS05930	COG0280	phosphate acetyltransferase
D1822_RS05940	COG0295	cytidine deaminase activity
D1822_RS05945	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
D1822_RS05950	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
D1822_RS05955	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D1822_RS05970	COG0318	PFAM AMP-dependent synthetase and ligase
D1822_RS05985	COG1250	3-hydroxyacyl-CoA dehydrogenase
D1822_RS05985	COG1024	Enoyl-CoA hydratase
D1822_RS05990	COG0183	Belongs to the thiolase family
D1822_RS05995	COG0625	glutathione transferase activity
D1822_RS06005	COG1960	acyl-CoA dehydrogenase activity
D1822_RS06015	COG1960	acyl-CoA dehydrogenase activity
D1822_RS06020	COG0789	Transcriptional regulator
D1822_RS06040	COG0534	Mate efflux family protein
D1822_RS06060	COG0737	Belongs to the 5'-nucleotidase family
D1822_RS06075	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
D1822_RS06080	COG0709	Synthesizes selenophosphate from selenide and ATP
D1822_RS06085	COG1320	monovalent cation:proton antiporter activity
D1822_RS06090	COG2212	antiporter activity
D1822_RS06105	COG1006	Multisubunit Na H antiporter MnhC subunit
D1822_RS06110	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D1822_RS06110	COG2111	Na H antiporter
D1822_RS06125	COG2943	transferase activity, transferring hexosyl groups
D1822_RS06130	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
D1822_RS06145	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D1822_RS06160	COG2391	methyltransferase activity
D1822_RS06175	COG0785	Cytochrome C biogenesis protein
D1822_RS06200	COG3258	Cytochrome c
D1822_RS06205	COG0737	Belongs to the 5'-nucleotidase family
D1822_RS06235	COG0740	serine-type endopeptidase activity
D1822_RS06240	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
D1822_RS06270	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
D1822_RS06275	COG0439	Biotin carboxylase
D1822_RS06290	COG0410	ABC transporter
D1822_RS06350	COG2391	methyltransferase activity
D1822_RS06370	COG3750	Belongs to the UPF0335 family
D1822_RS06390	COG1309	transcriptional regulator
D1822_RS06405	COG1116	anion transmembrane transporter activity
D1822_RS06410	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D1822_RS06415	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D1822_RS06420	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D1822_RS06440	COG0563	adenylate kinase activity
D1822_RS06445	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D1822_RS06475	COG0745	RESPONSE REGULATOR receiver
D1822_RS06480	COG2205	protein histidine kinase activity
D1822_RS06505	COG0673	inositol 2-dehydrogenase activity
D1822_RS06510	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D1822_RS06520	COG4989	oxidoreductase activity
D1822_RS06540	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D1822_RS06575	COG1175	transmembrane transport
D1822_RS06595	COG0583	DNA-binding transcription factor activity
D1822_RS06605	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
D1822_RS06610	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
D1822_RS06620	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
D1822_RS06630	COG2166	iron-sulfur cluster assembly
D1822_RS06650	COG5012	cobalamin binding
D1822_RS06660	COG1410	methionine synthase
D1822_RS06660	COG0646	methionine synthase
D1822_RS06675	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
D1822_RS06680	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D1822_RS06685	COG0047	phosphoribosylformylglycinamidine synthase activity
D1822_RS06695	COG2204	response regulator
D1822_RS06700	COG1530	ribonuclease E activity
D1822_RS06710	COG0425	Belongs to the sulfur carrier protein TusA family
D1822_RS06715	COG0785	Cytochrome C biogenesis protein
D1822_RS06725	COG2124	cytochrome p450
D1822_RS06745	COG0114	fumarate hydratase activity
D1822_RS06760	COG2059	Chromate
D1822_RS06780	COG0577	efflux transmembrane transporter activity
D1822_RS06780	COG1136	(ABC) transporter
D1822_RS06845	COG0318	PFAM AMP-dependent synthetase and ligase
D1822_RS06855	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D1822_RS06865	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D1822_RS06870	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D1822_RS06880	COG1960	acyl-CoA dehydrogenase activity
D1822_RS06885	COG2091	lysine biosynthetic process via aminoadipic acid
D1822_RS06895	COG1917	Cupin 2, conserved barrel domain protein
D1822_RS06895	COG2207	Transcriptional regulator
D1822_RS06910	COG2186	Transcriptional regulator
D1822_RS06915	COG0604	alcohol dehydrogenase
D1822_RS06920	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D1822_RS06930	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D1822_RS06935	COG0415	Belongs to the DNA photolyase family
D1822_RS06940	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
D1822_RS06950	COG0494	nUDIX hydrolase
D1822_RS06960	COG3264	Mechanosensitive ion channel
D1822_RS06960	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
D1822_RS06965	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D1822_RS06980	COG2115	Belongs to the xylose isomerase family
D1822_RS06985	COG1070	Carbohydrate kinase
D1822_RS07005	COG4536	flavin adenine dinucleotide binding
D1822_RS07010	COG4974	Belongs to the 'phage' integrase family
D1822_RS07020	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
D1822_RS07025	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
D1822_RS07030	COG0840	transmembrane signaling receptor activity
D1822_RS07035	COG0629	single-stranded DNA binding
D1822_RS07040	COG1196	nuclear chromosome segregation
D1822_RS07040	COG0739	heme binding
D1822_RS07040	COG0741	lytic transglycosylase activity
D1822_RS07050	COG4172	Belongs to the ABC transporter superfamily
D1822_RS07060	COG0601	transmembrane transport
D1822_RS07075	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
D1822_RS07080	COG0528	UMP kinase activity
D1822_RS07085	COG0233	cytoplasmic translational termination
D1822_RS07090	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D1822_RS07100	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
D1822_RS07105	COG0750	zinc metalloprotease
D1822_RS07110	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D1822_RS07120	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D1822_RS07125	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D1822_RS07130	COG3494	Protein of unknown function (DUF1009)
D1822_RS07135	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D1822_RS07140	COG0482	sulfurtransferase activity
D1822_RS07155	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D1822_RS07160	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D1822_RS07170	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
D1822_RS07175	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D1822_RS07185	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
D1822_RS07190	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
D1822_RS07205	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
D1822_RS07210	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
D1822_RS07220	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D1822_RS07225	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
D1822_RS07235	COG1309	transcriptional regulator
D1822_RS07240	COG2326	polyphosphate kinase activity
D1822_RS07250	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
D1822_RS07265	COG2962	Rard protein
D1822_RS07275	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D1822_RS07275	COG0519	Catalyzes the synthesis of GMP from XMP
D1822_RS07280	COG5598	trimethylamine methyltransferase
D1822_RS07300	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
D1822_RS07305	COG1473	amidohydrolase
D1822_RS07315	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
D1822_RS07320	COG2867	negative regulation of translational initiation
D1822_RS07325	COG0004	ammonium transporteR
D1822_RS07330	COG1058	Belongs to the CinA family
D1822_RS07330	COG1546	Belongs to the CinA family
D1822_RS07335	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
D1822_RS07340	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
D1822_RS07340	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
D1822_RS07345	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D1822_RS07350	COG3852	Histidine kinase
D1822_RS07355	COG2204	response regulator
D1822_RS07360	COG5000	phosphorelay sensor kinase activity
D1822_RS07365	COG2204	response regulator
D1822_RS07375	COG0569	domain protein
D1822_RS07380	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D1822_RS07385	COG1923	regulation of RNA biosynthetic process
D1822_RS07390	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D1822_RS07395	COG2366	antibiotic biosynthetic process
D1822_RS07400	COG2084	Dehydrogenase
D1822_RS07420	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D1822_RS07425	COG2814	Major facilitator Superfamily
D1822_RS07465	COG4166	transmembrane transport
D1822_RS07470	COG1028	Short-chain dehydrogenase reductase Sdr
D1822_RS07485	COG2313	pseudouridylate synthase activity
D1822_RS07515	COG1612	heme a metabolic process
D1822_RS07530	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D1822_RS07535	COG5425	PFAM Usg family protein
D1822_RS07540	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
D1822_RS07565	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D1822_RS07570	COG0517	IMP dehydrogenase activity
D1822_RS07570	COG0516	GMP reductase activity
D1822_RS07590	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
D1822_RS07595	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D1822_RS07610	COG1217	gtp-binding protein TYPA
D1822_RS07630	COG2945	thiolester hydrolase activity
D1822_RS07635	COG1959	2 iron, 2 sulfur cluster binding
D1822_RS07645	COG0719	Fe-S assembly protein
D1822_RS07655	COG0393	Putative heavy-metal-binding
D1822_RS07660	COG0396	ATPase activity
D1822_RS07665	COG0719	Fe-S assembly protein
D1822_RS07680	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D1822_RS07700	COG0261	This protein binds to 23S rRNA in the presence of protein L20
D1822_RS07700	COG3743	rRNA binding
D1822_RS07705	COG0211	Belongs to the bacterial ribosomal protein bL27 family
D1822_RS07715	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
D1822_RS07720	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
D1822_RS07725	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
D1822_RS07750	COG0052	Belongs to the universal ribosomal protein uS2 family
D1822_RS07755	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
D1822_RS07760	COG2771	luxR family
D1822_RS07765	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
D1822_RS07790	COG1024	Enoyl-CoA hydratase
D1822_RS07795	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D1822_RS07800	COG1946	Acyl-CoA thioesterase
D1822_RS07805	COG1028	Short-chain dehydrogenase reductase Sdr
D1822_RS07810	COG1960	acyl-CoA dehydrogenase activity
D1822_RS07815	COG0583	DNA-binding transcription factor activity
D1822_RS07820	COG0745	RESPONSE REGULATOR receiver
D1822_RS07825	COG0704	Plays a role in the regulation of phosphate uptake
D1822_RS07830	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D1822_RS07840	COG0573	inorganic phosphate transmembrane transporter activity
D1822_RS07850	COG5002	protein histidine kinase activity
D1822_RS07855	COG0626	cystathionine gamma-synthase activity
D1822_RS07865	COG0194	GDP metabolic process
D1822_RS07870	COG1561	YicC-like family, N-terminal region
D1822_RS07880	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
D1822_RS07890	COG2133	pyrroloquinoline quinone binding
D1822_RS07925	COG0433	COG0433 Predicted ATPase
D1822_RS07950	COG2989	Protein conserved in bacteria
D1822_RS07955	COG3108	Peptidase M15
D1822_RS07970	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
D1822_RS07980	COG0248	Ppx GppA phosphatase
D1822_RS07985	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
D1822_RS08020	COG0577	efflux transmembrane transporter activity
D1822_RS08050	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
D1822_RS08070	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
D1822_RS08075	COG0235	Class ii aldolase
D1822_RS08085	COG0747	negative chemotaxis
D1822_RS08090	COG0601	transmembrane transport
D1822_RS08095	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D1822_RS08100	COG0444	Belongs to the ABC transporter superfamily
D1822_RS08105	COG4608	Belongs to the ABC transporter superfamily
D1822_RS08110	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
D1822_RS08120	COG1238	metal cluster binding
D1822_RS08135	COG0010	Belongs to the arginase family
D1822_RS08170	COG2814	Major facilitator Superfamily
D1822_RS08180	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D1822_RS08185	COG0215	cysteine-tRNA ligase activity
D1822_RS08255	COG1522	sequence-specific DNA binding
D1822_RS08285	COG3842	ATPase activity
D1822_RS08290	COG0395	ABC-type sugar transport system, permease component
D1822_RS08315	COG0004	ammonium transporteR
D1822_RS08320	COG0738	Major facilitator superfamily
D1822_RS08325	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D1822_RS08340	COG1278	Cold shock
D1822_RS08345	COG0259	pyridoxamine-phosphate oxidase activity
D1822_RS08350	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D1822_RS08360	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
D1822_RS08370	COG0436	Aminotransferase
D1822_RS08375	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D1822_RS08380	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D1822_RS08395	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D1822_RS08400	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
D1822_RS08410	COG0315	cyclic pyranopterin monophosphate synthase activity
D1822_RS08415	COG0303	'Molybdopterin
D1822_RS08420	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
D1822_RS08430	COG0658	competence protein
D1822_RS08430	COG2333	competence protein COMEC
D1822_RS08435	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D1822_RS08440	COG0372	Belongs to the citrate synthase family
D1822_RS08450	COG1024	Enoyl-CoA hydratase
D1822_RS08455	COG3088	subunit of a heme lyase
D1822_RS08460	COG1138	Cytochrome C-type biogenesis protein
D1822_RS08475	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
D1822_RS08480	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
D1822_RS08485	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
D1822_RS08500	COG0583	DNA-binding transcription factor activity
D1822_RS08515	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D1822_RS08525	COG1357	PFAM Pentapeptide repeats (8 copies)
D1822_RS08540	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
D1822_RS08565	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
D1822_RS08570	COG2354	Protein conserved in bacteria
D1822_RS08580	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
D1822_RS08585	COG0517	IMP dehydrogenase activity
D1822_RS08585	COG0516	GMP reductase activity
D1822_RS08600	COG3239	Fatty acid desaturase
D1822_RS08630	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D1822_RS08640	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D1822_RS08655	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
D1822_RS08665	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D1822_RS08670	COG2833	Protein of unknown function (DUF455)
D1822_RS08675	COG0739	heme binding
D1822_RS08710	COG0126	phosphoglycerate kinase activity
D1822_RS08715	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
D1822_RS08720	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D1822_RS08725	COG0508	dehydrogenase complex catalyzes the overall conversion of
D1822_RS08725	COG0022	dehydrogenase e1 component
D1822_RS08730	COG0508	dehydrogenase complex catalyzes the overall conversion of
D1822_RS08780	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D1822_RS08870	COG4695	Portal protein
D1822_RS08885	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D1822_RS08890	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D1822_RS08900	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
D1822_RS08905	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D1822_RS08915	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
D1822_RS08935	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D1822_RS08940	COG0473	3-isopropylmalate dehydrogenase activity
D1822_RS08970	COG2353	YceI-like domain
D1822_RS08985	COG0360	Binds together with S18 to 16S ribosomal RNA
D1822_RS08990	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
D1822_RS08995	COG0359	binds to the 23S rRNA
D1822_RS09010	COG0737	Belongs to the 5'-nucleotidase family
D1822_RS09020	COG0544	peptidyl-prolyl cis-trans isomerase activity
D1822_RS09030	COG0840	transmembrane signaling receptor activity
D1822_RS09040	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
D1822_RS09065	COG0006	proline dipeptidase activity
D1822_RS09080	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D1822_RS09115	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D1822_RS09125	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D1822_RS09130	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D1822_RS09135	COG4133	protoheme IX ABC transporter activity
D1822_RS09140	COG3737	Protein of unknown function (DUF498/DUF598)
D1822_RS09145	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D1822_RS09150	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D1822_RS09155	COG1862	Preprotein translocase
D1822_RS09165	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
D1822_RS09175	COG3239	Fatty acid desaturase
D1822_RS09180	COG1160	GTP binding
D1822_RS09200	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D1822_RS09210	COG5265	(ABC) transporter
D1822_RS09255	COG0446	pyridine nucleotide-disulphide oxidoreductase
D1822_RS09255	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D1822_RS09265	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D1822_RS09270	COG4235	cytochrome complex assembly
D1822_RS09275	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
D1822_RS09290	COG0730	response to heat
D1822_RS09295	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D1822_RS09330	COG1475	DNA binding
D1822_RS09355	COG1012	belongs to the aldehyde dehydrogenase family
D1822_RS09360	COG0028	Belongs to the TPP enzyme family
D1822_RS09370	COG4974	Belongs to the 'phage' integrase family
D1822_RS09380	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
D1822_RS09385	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D1822_RS09405	COG2186	Transcriptional regulator
D1822_RS09420	COG1175	transmembrane transport
D1822_RS09425	COG1653	transport
D1822_RS09455	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D1822_RS09480	COG2197	response regulator
D1822_RS09490	COG1294	oxidase, subunit
D1822_RS09495	COG1271	oxidase subunit
D1822_RS09535	COG0105	UTP biosynthetic process
D1822_RS09540	COG0488	(ABC) transporter
D1822_RS09545	COG2095	MarC family integral membrane protein
D1822_RS09560	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D1822_RS09580	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D1822_RS09585	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
D1822_RS09590	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D1822_RS09600	COG2890	protein-(glutamine-N5) methyltransferase activity
D1822_RS09605	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
D1822_RS09625	COG0010	Belongs to the arginase family
D1822_RS09630	COG1473	amidohydrolase
D1822_RS09635	COG3956	TIGRFAM MazG family protein
D1822_RS09645	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D1822_RS09655	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
D1822_RS09665	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
D1822_RS09725	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
D1822_RS09730	COG0346	lactoylglutathione lyase activity
D1822_RS09735	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D1822_RS09760	COG0028	Belongs to the TPP enzyme family
D1822_RS09765	COG0440	acetolactate synthase activity
D1822_RS09790	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
D1822_RS09795	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
D1822_RS09800	COG0860	N-Acetylmuramoyl-L-alanine amidase
D1822_RS09805	COG0436	Aminotransferase
D1822_RS09820	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
D1822_RS09830	COG0156	8-amino-7-oxononanoate synthase activity
D1822_RS09865	COG0406	alpha-ribazole phosphatase activity
D1822_RS09900	COG1522	sequence-specific DNA binding
D1822_RS09930	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D1822_RS09950	COG0343	queuine tRNA-ribosyltransferase activity
D1822_RS09970	COG0523	cobalamin synthesis protein
D1822_RS09975	COG2151	metal-sulfur cluster biosynthetic enzyme
D1822_RS09985	COG0316	Belongs to the HesB IscA family
D1822_RS09990	COG0149	triose-phosphate isomerase activity
D1822_RS09995	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D1822_RS10000	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D1822_RS10005	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D1822_RS10010	COG2204	response regulator
D1822_RS10020	COG2124	cytochrome p450
D1822_RS10030	COG1522	sequence-specific DNA binding
D1822_RS10035	COG1648	precorrin-2 dehydrogenase activity
D1822_RS10035	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D1822_RS10045	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D1822_RS10050	COG0175	sulfate reduction
D1822_RS10075	COG3443	Belongs to the bacterial solute-binding protein 9 family
D1822_RS10085	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
D1822_RS10090	COG0840	transmembrane signaling receptor activity
D1822_RS10115	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
D1822_RS10130	COG3243	poly(R)-hydroxyalkanoic acid synthase
D1822_RS10165	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D1822_RS10175	COG3220	belongs to the UPF0276 family
D1822_RS10195	COG1393	Belongs to the ArsC family
D1822_RS10200	COG1278	Cold shock
D1822_RS10205	COG1012	belongs to the aldehyde dehydrogenase family
D1822_RS10210	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D1822_RS10220	COG2267	carboxylic ester hydrolase activity
D1822_RS10230	COG1802	Transcriptional regulator
D1822_RS10260	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
D1822_RS10275	COG0346	lactoylglutathione lyase activity
D1822_RS10280	COG1846	Transcriptional regulator
D1822_RS10325	COG0534	Mate efflux family protein
D1822_RS10345	COG0187	DNA topoisomerase II activity
D1822_RS10360	COG0243	molybdopterin cofactor binding
D1822_RS10370	COG1136	(ABC) transporter
D1822_RS10380	COG0442	prolyl-tRNA aminoacylation
D1822_RS10385	COG0628	permease
D1822_RS10395	COG0248	Ppx GppA phosphatase
D1822_RS10410	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
D1822_RS10425	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D1822_RS10425	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D1822_RS10445	COG4770	biotin carboxylase activity
D1822_RS10465	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D1822_RS10470	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
D1822_RS10480	COG3800	Transcriptional regulator
D1822_RS10480	COG1396	sequence-specific DNA binding
D1822_RS10505	COG3119	arylsulfatase activity
D1822_RS10515	COG1309	transcriptional regulator
D1822_RS10525	COG0697	spore germination
D1822_RS10550	COG0217	transcriptional regulatory protein
D1822_RS10555	COG3273	potassium ion transport
D1822_RS10555	COG0471	metal ion transport
D1822_RS10565	COG0471	metal ion transport
D1822_RS10565	COG3273	potassium ion transport
D1822_RS10570	COG1692	metallophosphoesterase
D1822_RS10575	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
D1822_RS10580	COG2239	Acts as a magnesium transporter
D1822_RS10585	COG0402	S-adenosylhomocysteine deaminase activity
D1822_RS10595	COG0483	inositol monophosphate 1-phosphatase activity
D1822_RS10600	COG1396	sequence-specific DNA binding
D1822_RS10605	COG1028	Short-chain dehydrogenase reductase Sdr
D1822_RS10605	COG3321	synthase
D1822_RS10605	COG0604	alcohol dehydrogenase
D1822_RS10610	COG0583	DNA-binding transcription factor activity
D1822_RS10625	COG0670	Belongs to the BI1 family
D1822_RS10635	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D1822_RS10655	COG0154	amidase activity
D1822_RS10660	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D1822_RS10665	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
D1822_RS10670	COG2818	Glycosylase
D1822_RS10675	COG0590	tRNA wobble adenosine to inosine editing
D1822_RS10680	COG1187	pseudouridine synthase activity
D1822_RS10690	COG3853	Toxic anion resistance protein (TelA)
D1822_RS10720	COG1490	D-aminoacyl-tRNA deacylase activity
D1822_RS10735	COG0601	transmembrane transport
D1822_RS10740	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D1822_RS10765	COG0318	PFAM AMP-dependent synthetase and ligase
D1822_RS10770	COG1132	(ABC) transporter
D1822_RS10795	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D1822_RS10915	COG1802	Transcriptional regulator
D1822_RS10915	COG4626	Terminase
D1822_RS11025	COG0784	Response regulator, receiver
D1822_RS11025	COG5002	protein histidine kinase activity
D1822_RS11025	COG2198	Histidine kinase
D1822_RS11075	COG1960	acyl-CoA dehydrogenase activity
D1822_RS11085	COG0183	Belongs to the thiolase family
D1822_RS11090	COG1024	Enoyl-CoA hydratase
D1822_RS11090	COG1250	3-hydroxyacyl-CoA dehydrogenase
D1822_RS11100	COG0318	PFAM AMP-dependent synthetase and ligase
D1822_RS11105	COG0583	DNA-binding transcription factor activity
D1822_RS11110	COG0517	IMP dehydrogenase activity
D1822_RS11110	COG4175	Glycine betaine
D1822_RS11115	COG4176	ABC-type proline glycine betaine transport system permease component
D1822_RS11130	COG0741	lytic transglycosylase activity
D1822_RS11145	COG3451	type IV secretory pathway VirB4
D1822_RS11150	COG0741	lytic transglycosylase activity
D1822_RS11150	COG1196	nuclear chromosome segregation
D1822_RS11150	COG0739	heme binding
D1822_RS11240	COG4227	nucleotidyltransferase activity
D1822_RS11250	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
D1822_RS11255	COG1129	ABC transporter
D1822_RS11265	COG1172	Belongs to the binding-protein-dependent transport system permease family
D1822_RS11270	COG1028	Short-chain dehydrogenase reductase Sdr
D1822_RS11275	COG1879	ABC-type sugar transport system periplasmic component
D1822_RS11290	COG0006	proline dipeptidase activity
D1822_RS11295	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D1822_RS11300	COG0022	dehydrogenase e1 component
D1822_RS11305	COG0508	dehydrogenase complex catalyzes the overall conversion of
D1822_RS11320	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D1822_RS11335	COG3550	peptidyl-serine autophosphorylation
D1822_RS11360	COG1349	DNA-binding transcription factor activity
D1822_RS11365	COG2113	Glycine betaine
D1822_RS11370	COG4175	Glycine betaine
D1822_RS11370	COG3448	diguanylate cyclase activity
D1822_RS11405	COG0174	glutamine synthetase
D1822_RS11430	COG1349	DNA-binding transcription factor activity
D1822_RS11460	COG1024	Enoyl-CoA hydratase
D1822_RS11470	COG1028	Short-chain dehydrogenase reductase Sdr
D1822_RS11480	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D1822_RS11485	COG0527	aspartate kinase activity
D1822_RS11490	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D1822_RS11500	COG1469	GTP cyclohydrolase I activity
D1822_RS11510	COG2917	probably involved in intracellular septation
D1822_RS11520	COG0552	protein localization to endoplasmic reticulum
D1822_RS11535	COG1570	exodeoxyribonuclease VII activity
D1822_RS11545	COG3781	membrane
D1822_RS11590	COG0330	HflC and HflK could
D1822_RS11595	COG0330	HflC and HflK could
D1822_RS11610	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
D1822_RS11620	COG0625	glutathione transferase activity
D1822_RS11625	COG1760	l-serine dehydratase
D1822_RS11650	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
D1822_RS11690	COG0504	CTP synthase activity
D1822_RS11695	COG3588	fructose-bisphosphate aldolase
D1822_RS11700	COG1024	Enoyl-CoA hydratase
D1822_RS11705	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D1822_RS11710	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
D1822_RS11715	COG1132	(ABC) transporter
D1822_RS11720	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D1822_RS11730	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D1822_RS11740	COG1492	cobalamin metabolic process
D1822_RS11755	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D1822_RS11760	COG2824	Alkylphosphonate utilization operon protein PhnA
D1822_RS11765	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D1822_RS11770	COG5510	response to toxic substance
D1822_RS11785	COG0481	GTPase activity
D1822_RS11805	COG0583	DNA-binding transcription factor activity
D1822_RS11810	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D1822_RS11825	COG0227	Belongs to the bacterial ribosomal protein bL28 family
D1822_RS11830	COG1703	isobutyryl-CoA mutase activity
D1822_RS11835	COG1643	Atp-dependent helicase
D1822_RS11845	COG0306	phosphate transporter
D1822_RS11850	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
D1822_RS11855	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D1822_RS11865	COG0842	Transport permease protein
D1822_RS11880	COG0625	glutathione transferase activity
D1822_RS11905	COG2877	3-deoxy-8-phosphooctulonate synthase activity
D1822_RS11925	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D1822_RS11955	COG1739	Uncharacterized protein family UPF0029
D1822_RS11970	COG1872	DUF167
D1822_RS11975	COG0778	Nitroreductase
D1822_RS11990	COG0346	lactoylglutathione lyase activity
D1822_RS12015	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
D1822_RS12025	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D1822_RS12025	COG0512	Glutamine amidotransferase of anthranilate synthase
D1822_RS12030	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D1822_RS12040	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D1822_RS12045	COG3591	Belongs to the peptidase S1B family
D1822_RS12060	COG1846	Transcriptional regulator
D1822_RS12070	COG0431	NADPH-dependent FMN reductase
D1822_RS12080	COG1435	thymidine kinase activity
D1822_RS12090	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D1822_RS12110	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
D1822_RS12120	COG1496	oxidoreductase activity
D1822_RS12130	COG1522	sequence-specific DNA binding
D1822_RS12135	COG0492	ferredoxin-NADP+ reductase activity
D1822_RS12145	COG0529	Catalyzes the synthesis of activated sulfate
D1822_RS12145	COG2046	Belongs to the sulfate adenylyltransferase family
D1822_RS12155	COG0384	phenazine biosynthesis protein PhzF
D1822_RS12165	COG0071	Belongs to the small heat shock protein (HSP20) family
D1822_RS12175	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
D1822_RS12180	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
D1822_RS12185	COG3454	Phosphonate metabolism
D1822_RS12200	COG3153	acetyltransferase
D1822_RS12205	COG0459	protein refolding
D1822_RS12210	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
D1822_RS12220	COG1227	inorganic diphosphatase activity
D1822_RS12235	COG2030	dehydratase
D1822_RS12240	COG0196	riboflavin kinase activity
D1822_RS12245	COG2983	Belongs to the UPF0260 family
D1822_RS12265	COG0596	Alpha beta hydrolase
D1822_RS12285	COG0355	proton-transporting ATP synthase activity, rotational mechanism
D1822_RS12290	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
D1822_RS12295	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
D1822_RS12300	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
D1822_RS12305	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D1822_RS12315	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D1822_RS12345	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
D1822_RS12360	COG0287	Prephenate dehydrogenase
D1822_RS12365	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D1822_RS12370	COG1522	sequence-specific DNA binding
D1822_RS12380	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
D1822_RS12390	COG0318	PFAM AMP-dependent synthetase and ligase
D1822_RS12395	COG0543	2 iron, 2 sulfur cluster binding
D1822_RS12395	COG0633	Ferredoxin
D1822_RS12405	COG0446	pyridine nucleotide-disulphide oxidoreductase
D1822_RS12405	COG1902	pentaerythritol trinitrate reductase activity
D1822_RS12465	COG0154	amidase activity
D1822_RS12475	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
D1822_RS12490	COG2515	1-aminocyclopropane-1-carboxylate deaminase
D1822_RS12510	COG0583	DNA-binding transcription factor activity
D1822_RS12520	COG4176	ABC-type proline glycine betaine transport system permease component
D1822_RS12525	COG0517	IMP dehydrogenase activity
D1822_RS12525	COG4175	Glycine betaine
D1822_RS12580	COG0446	pyridine nucleotide-disulphide oxidoreductase
D1822_RS12580	COG1902	pentaerythritol trinitrate reductase activity
D1822_RS12595	COG3383	formate dehydrogenase (NAD+) activity
D1822_RS12600	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
D1822_RS12605	COG0583	DNA-binding transcription factor activity
D1822_RS12615	COG0840	transmembrane signaling receptor activity
D1822_RS12625	COG0488	(ABC) transporter
D1822_RS12650	COG4695	Portal protein
D1822_RS12675	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D1822_RS12680	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D1822_RS12685	COG1120	ATPase activity
D1822_RS12695	COG0811	peptide transport
D1822_RS12715	COG4774	siderophore transport
D1822_RS12725	COG1846	Transcriptional regulator
D1822_RS12795	COG0556	nucleotide-excision repair
D1822_RS12840	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
D1822_RS12865	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
D1822_RS12905	COG1376	ErfK ybiS ycfS ynhG family protein
D1822_RS12910	COG1278	Cold shock
D1822_RS12920	COG4181	ATPase activity
D1822_RS12930	COG1959	2 iron, 2 sulfur cluster binding
D1822_RS12945	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D1822_RS12950	COG3706	GGDEF domain
D1822_RS12965	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D1822_RS12970	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
D1822_RS12975	COG2957	Belongs to the agmatine deiminase family
D1822_RS12995	COG0768	penicillin binding
D1822_RS13000	COG0772	Belongs to the SEDS family
D1822_RS13005	COG0583	DNA-binding transcription factor activity
D1822_RS13015	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D1822_RS13025	COG0339	signal peptide processing
D1822_RS13030	COG0765	amino acid transport
D1822_RS13035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D1822_RS13040	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D1822_RS13045	COG0756	dUTP diphosphatase activity
D1822_RS13050	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D1822_RS13080	COG0606	chelatase, subunit chli
D1822_RS13090	COG0792	nuclease activity
D1822_RS13095	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
D1822_RS13105	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
D1822_RS13120	COG0180	Tryptophanyl-tRNA synthetase
D1822_RS13125	COG1278	Cold shock
D1822_RS13130	COG1309	transcriptional regulator
D1822_RS13140	COG2050	protein possibly involved in aromatic compounds catabolism
D1822_RS13145	COG1024	Enoyl-CoA hydratase
D1822_RS13150	COG1012	belongs to the aldehyde dehydrogenase family
D1822_RS13150	COG2030	dehydratase
D1822_RS13155	COG3327	negative regulation of DNA-templated transcription, initiation
D1822_RS13165	COG1120	ATPase activity
D1822_RS13175	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D1822_RS13180	COG0251	oxidation-reduction process
D1822_RS13190	COG3845	ABC transporter
D1822_RS13195	COG4603	Belongs to the binding-protein-dependent transport system permease family
D1822_RS13200	COG1079	Belongs to the binding-protein-dependent transport system permease family
D1822_RS13205	COG0402	S-adenosylhomocysteine deaminase activity
D1822_RS13240	COG3237	CsbD-like
D1822_RS13265	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D1822_RS13285	COG0784	Response regulator, receiver
D1822_RS13330	COG0174	glutamine synthetase
D1822_RS13350	COG2175	clavaminate synthase activity
D1822_RS13355	COG0583	DNA-binding transcription factor activity
D1822_RS13365	COG0745	RESPONSE REGULATOR receiver
D1822_RS13370	COG5002	protein histidine kinase activity
D1822_RS13380	COG4251	negative regulation of phosphorylation
D1822_RS13385	COG2197	response regulator
D1822_RS13410	COG1175	transmembrane transport
D1822_RS13415	COG0395	ABC-type sugar transport system, permease component
D1822_RS13425	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
D1822_RS13435	COG1028	Short-chain dehydrogenase reductase Sdr
D1822_RS13440	COG1609	Transcriptional regulator
D1822_RS13455	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
D1822_RS13470	COG0840	transmembrane signaling receptor activity
D1822_RS13490	COG3806	Anti-sigma factor
D1822_RS13495	COG1595	DNA-templated transcription, initiation
D1822_RS13510	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
D1822_RS13535	COG1028	Short-chain dehydrogenase reductase Sdr
D1822_RS13540	COG3852	Histidine kinase
D1822_RS13560	COG0437	4 iron, 4 sulfur cluster binding
D1822_RS13565	COG3383	formate dehydrogenase (NAD+) activity
D1822_RS13565	COG0243	molybdopterin cofactor binding
D1822_RS13600	COG0489	protein tyrosine kinase activity
D1822_RS13620	COG1126	abc transporter atp-binding protein
D1822_RS13630	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
D1822_RS13635	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
D1822_RS13670	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D1822_RS13675	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
D1822_RS13680	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D1822_RS13685	COG2188	Transcriptional regulator
D1822_RS13695	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
D1822_RS13705	COG1175	transmembrane transport
D1822_RS13710	COG0395	ABC-type sugar transport system, permease component
D1822_RS13715	COG0673	inositol 2-dehydrogenase activity
D1822_RS13725	COG0166	Belongs to the GPI family
D1822_RS13730	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
D1822_RS13735	COG0129	dihydroxy-acid dehydratase activity
D1822_RS13740	COG0800	Aldolase
D1822_RS13755	COG1072	(Pantothenic acid kinase))
D1822_RS13795	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D1822_RS13805	COG3845	ABC transporter
D1822_RS13810	COG4603	Belongs to the binding-protein-dependent transport system permease family
D1822_RS13820	COG1079	Belongs to the binding-protein-dependent transport system permease family
D1822_RS13830	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D1822_RS13860	COG0277	FAD linked oxidase domain protein
D1822_RS13865	COG0405	Gamma-glutamyltransferase
D1822_RS13905	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D1822_RS13915	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
D1822_RS13925	COG1280	lysine exporter protein (LysE YggA)
D1822_RS13945	COG0444	Belongs to the ABC transporter superfamily
D1822_RS13950	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D1822_RS13955	COG0601	transmembrane transport
D1822_RS13965	COG0747	negative chemotaxis
D1822_RS13975	COG0745	RESPONSE REGULATOR receiver
D1822_RS13980	COG4191	Histidine kinase
D1822_RS13980	COG0784	Response regulator, receiver
D1822_RS13985	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D1822_RS14010	COG0673	inositol 2-dehydrogenase activity
D1822_RS14075	COG4251	negative regulation of phosphorylation
D1822_RS14085	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
D1822_RS14090	COG1984	allophanate hydrolase subunit 2
D1822_RS14100	COG0121	glutamine amidotransferase
D1822_RS14110	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D1822_RS14120	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D1822_RS14140	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D1822_RS14145	COG0028	Belongs to the TPP enzyme family
D1822_RS14155	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D1822_RS14160	COG0280	phosphate acetyltransferase
D1822_RS14165	COG0372	Belongs to the citrate synthase family
D1822_RS14170	COG0243	molybdopterin cofactor binding
D1822_RS14180	COG0437	4 iron, 4 sulfur cluster binding
D1822_RS14185	COG3302	dmso reductase anchor subunit
D1822_RS14190	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D1822_RS14200	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D1822_RS14205	COG0741	lytic transglycosylase activity
D1822_RS14215	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
D1822_RS14215	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D1822_RS14255	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D1822_RS14260	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D1822_RS14265	COG1846	Transcriptional regulator
D1822_RS14270	COG0697	spore germination
D1822_RS14280	COG1051	belongs to the nudix hydrolase family
D1822_RS14285	COG0446	pyridine nucleotide-disulphide oxidoreductase
D1822_RS14285	COG1902	pentaerythritol trinitrate reductase activity
D1822_RS14290	COG0693	protein deglycase activity
D1822_RS14300	COG2329	Antibiotic biosynthesis monooxygenase
D1822_RS14315	COG0583	DNA-binding transcription factor activity
D1822_RS14320	COG2885	chlorophyll binding
D1822_RS14335	COG1058	Belongs to the CinA family
D1822_RS14335	COG1546	Belongs to the CinA family
D1822_RS14340	COG1489	DNA binding
D1822_RS14345	COG0668	transmembrane transport
D1822_RS14350	COG0024	Methionine aminopeptidase
D1822_RS14360	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D1822_RS14365	COG0742	ribosomal rna small subunit methyltransferase
D1822_RS14375	COG0678	peroxiredoxin activity
D1822_RS14375	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D1822_RS14380	COG2154	pterin-4-alpha-carbinolamine dehydratase
D1822_RS14400	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D1822_RS14425	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D1822_RS14430	COG0347	Belongs to the P(II) protein family
D1822_RS14435	COG0004	ammonium transporteR
D1822_RS14445	COG2897	thiosulfate sulfurtransferase activity
D1822_RS14455	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
D1822_RS14465	COG1396	sequence-specific DNA binding
D1822_RS14470	COG3135	benzoate transporter
D1822_RS14475	COG0129	dihydroxy-acid dehydratase activity
D1822_RS14545	COG1183	phosphatidylcholine synthase activity
D1822_RS14570	COG0071	Belongs to the small heat shock protein (HSP20) family
D1822_RS14575	COG3591	Belongs to the peptidase S1B family
D1822_RS14580	COG3591	Belongs to the peptidase S1B family
D1822_RS14585	COG0247	lactate metabolic process
D1822_RS14590	COG0277	FAD linked oxidase domain protein
D1822_RS14595	COG0277	FAD linked oxidase domain protein
D1822_RS14610	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
D1822_RS14615	COG0799	negative regulation of ribosome biogenesis
D1822_RS14620	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
D1822_RS14620	COG3264	Mechanosensitive ion channel
D1822_RS14630	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
D1822_RS14635	COG0066	3-isopropylmalate dehydratase activity
D1822_RS14655	COG0473	3-isopropylmalate dehydrogenase activity
D1822_RS14660	COG0697	spore germination
D1822_RS14675	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
D1822_RS14685	COG0124	histidyl-tRNA synthetase
D1822_RS14695	COG2217	Heavy metal translocating P-type atpase
D1822_RS14700	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D1822_RS14705	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
D1822_RS14710	COG0181	hydroxymethylbilane synthase activity
D1822_RS14720	COG0408	coproporphyrinogen oxidase activity
D1822_RS14735	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
D1822_RS14750	COG1686	Belongs to the peptidase S11 family
D1822_RS14770	COG0348	domain, Protein
D1822_RS14780	COG2010	Cytochrome c
D1822_RS14805	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D1822_RS14810	COG4172	Belongs to the ABC transporter superfamily
D1822_RS14815	COG4239	(ABC) transporter, permease
D1822_RS14820	COG4174	ABC transporter (Permease)
D1822_RS14825	COG4166	transmembrane transport
D1822_RS14835	COG0077	Prephenate dehydratase
D1822_RS14835	COG1605	Chorismate mutase
D1822_RS14845	COG2816	NAD+ diphosphatase activity
D1822_RS14850	COG0737	Belongs to the 5'-nucleotidase family
D1822_RS14885	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
D1822_RS14910	COG3321	synthase
D1822_RS14910	COG0604	alcohol dehydrogenase
D1822_RS14910	COG1028	Short-chain dehydrogenase reductase Sdr
D1822_RS14920	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D1822_RS14925	COG2326	polyphosphate kinase activity
D1822_RS14935	COG1522	sequence-specific DNA binding
D1822_RS14945	COG1309	transcriptional regulator
D1822_RS14950	COG2130	NADP-dependent
D1822_RS14965	COG4948	Mandelate Racemase Muconate Lactonizing
D1822_RS14975	COG2301	Belongs to the HpcH HpaI aldolase family
D1822_RS15000	COG0825	malonyl-CoA metabolic process
D1822_RS15060	COG3093	addiction module antidote protein HigA
D1822_RS15080	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
D1822_RS15090	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
D1822_RS15140	COG1175	transmembrane transport
D1822_RS15145	COG0395	ABC-type sugar transport system, permease component
D1822_RS15150	COG1653	transport
D1822_RS15160	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
D1822_RS15210	COG2442	InterPro IPR007367
D1822_RS15245	COG0484	heat shock protein binding
D1822_RS15300	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
D1822_RS15305	COG1530	ribonuclease E activity
D1822_RS15315	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D1822_RS15320	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D1822_RS15345	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
D1822_RS15360	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D1822_RS15400	COG3842	ATPase activity
D1822_RS15420	COG1349	DNA-binding transcription factor activity
D1822_RS15430	COG2379	hydroxypyruvate reductase
D1822_RS15485	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D1822_RS15500	COG0288	reversible hydration of carbon dioxide
D1822_RS15510	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D1822_RS15515	COG0791	NLP P60 protein
D1822_RS15535	COG1309	transcriptional regulator
D1822_RS15545	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
D1822_RS15555	COG1671	Belongs to the UPF0178 family
D1822_RS15570	COG2423	ornithine cyclodeaminase activity
D1822_RS15575	COG2271	Major facilitator Superfamily
D1822_RS15580	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
D1822_RS15590	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
D1822_RS15620	COG1131	(ABC) transporter
D1822_RS15630	COG5001	Diguanylate cyclase
D1822_RS15630	COG3300	MHYT domain
D1822_RS15635	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D1822_RS15635	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D1822_RS15645	COG3622	Belongs to the hyi family
D1822_RS15655	COG0714	Associated with various cellular activities
D1822_RS15675	COG4953	penicillin-binding protein 1C
D1822_RS15680	COG2373	Large extracellular alpha-helical protein
D1822_RS15690	COG2205	protein histidine kinase activity
D1822_RS15690	COG5002	protein histidine kinase activity
D1822_RS15690	COG0784	Response regulator, receiver
D1822_RS15695	COG3022	response to hydroperoxide
D1822_RS15700	COG0514	ATP-dependent DNA helicase (RecQ)
D1822_RS15715	COG2270	Major facilitator Superfamily
D1822_RS15720	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
D1822_RS15745	COG3191	aminopeptidase activity
D1822_RS15750	COG3474	cytochrome
D1822_RS15755	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
D1822_RS15765	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
D1822_RS15770	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
D1822_RS15775	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
D1822_RS15795	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D1822_RS15815	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
D1822_RS15820	COG2205	protein histidine kinase activity
D1822_RS15820	COG0784	Response regulator, receiver
D1822_RS15820	COG2198	Histidine kinase
D1822_RS15825	COG1335	isochorismatase
D1822_RS15830	COG1054	Belongs to the UPF0176 family
D1822_RS15845	COG3971	2-oxopent-4-enoate hydratase activity
D1822_RS15850	COG0179	Fumarylacetoacetate (FAA) hydrolase
D1822_RS15860	COG1012	belongs to the aldehyde dehydrogenase family
D1822_RS15870	COG5441	Belongs to the UPF0261 family
D1822_RS15875	COG1012	belongs to the aldehyde dehydrogenase family
D1822_RS15900	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D1822_RS15940	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
D1822_RS15945	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D1822_RS15950	COG0069	glutamate synthase activity
D1822_RS15965	COG0542	response to heat
D1822_RS15970	COG0284	orotidine-5'-phosphate decarboxylase activity
D1822_RS15980	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D1822_RS15995	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D1822_RS16000	COG1840	ABC-type Fe3 transport system, periplasmic component
D1822_RS16010	COG0523	cobalamin synthesis protein
D1822_RS16015	COG1178	ABC-type Fe3 transport system permease component
D1822_RS16020	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
D1822_RS16065	COG4191	Histidine kinase
D1822_RS16085	COG0625	glutathione transferase activity
D1822_RS16120	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D1822_RS16125	COG1321	iron dependent repressor
D1822_RS16125	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D1822_RS16130	COG1121	(ABC) transporter
D1822_RS16135	COG0803	Belongs to the bacterial solute-binding protein 9 family
D1822_RS16145	COG1012	belongs to the aldehyde dehydrogenase family
D1822_RS16150	COG0612	Peptidase, M16
D1822_RS16155	COG0612	Peptidase, M16
D1822_RS16165	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D1822_RS16170	COG0138	bifunctional purine biosynthesis protein purh
D1822_RS16195	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
D1822_RS16200	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
D1822_RS16210	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
D1822_RS16225	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
D1822_RS16230	COG0500	methyltransferase
D1822_RS16235	COG1185	polyribonucleotide nucleotidyltransferase activity
D1822_RS16245	COG0450	alkyl hydroperoxide reductase
D1822_RS16275	COG0564	pseudouridine synthase activity
D1822_RS16315	COG1280	lysine exporter protein (LysE YggA)
D1822_RS16330	COG0183	Belongs to the thiolase family
D1822_RS16340	COG2172	sigma factor antagonist activity
D1822_RS16345	COG0405	Gamma-glutamyltransferase
D1822_RS16355	COG3118	belongs to the thioredoxin family
D1822_RS16365	COG2835	tetraacyldisaccharide 4'-kinase activity
D1822_RS16370	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D1822_RS16375	COG0154	amidase activity
D1822_RS16380	COG0436	Aminotransferase
D1822_RS16385	COG1674	ftsk spoiiie
D1822_RS16405	COG0745	RESPONSE REGULATOR receiver
D1822_RS16435	COG0495	leucyl-tRNA aminoacylation
D1822_RS16450	COG0625	glutathione transferase activity
D1822_RS16455	COG2081	HI0933 family
D1822_RS16465	COG1024	Enoyl-CoA hydratase
D1822_RS16480	COG0312	modulator of DNA gyrase
D1822_RS16495	COG1663	tetraacyldisaccharide 4'-kinase activity
D1822_RS16510	COG1194	a g-specific adenine glycosylase
D1822_RS16515	COG3239	Fatty acid desaturase
D1822_RS16530	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
D1822_RS16560	COG0022	dehydrogenase e1 component
D1822_RS16565	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D1822_RS16595	COG0583	DNA-binding transcription factor activity
D1822_RS16600	COG2515	1-aminocyclopropane-1-carboxylate deaminase
D1822_RS16610	COG0583	DNA-binding transcription factor activity
D1822_RS16620	COG3448	diguanylate cyclase activity
D1822_RS16620	COG4175	Glycine betaine
D1822_RS16625	COG4176	ABC-type proline glycine betaine transport system permease component
D1822_RS16630	COG2267	carboxylic ester hydrolase activity
D1822_RS16640	COG0235	Class ii aldolase
D1822_RS16645	COG3119	arylsulfatase activity
D1822_RS16680	COG1609	Transcriptional regulator
D1822_RS16685	COG3214	Protein conserved in bacteria
D1822_RS16705	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D1822_RS16720	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
D1822_RS16725	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D1822_RS16750	COG0625	glutathione transferase activity
D1822_RS16760	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
D1822_RS16765	COG1178	ABC-type Fe3 transport system permease component
D1822_RS16770	COG4143	(ABC) transporter
D1822_RS16775	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
D1822_RS16780	COG0318	PFAM AMP-dependent synthetase and ligase
D1822_RS16785	COG0697	spore germination
D1822_RS16790	COG1846	Transcriptional regulator
D1822_RS16795	COG1764	response to oxidative stress
D1822_RS16800	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D1822_RS16805	COG1846	Transcriptional regulator
D1822_RS16810	COG0745	RESPONSE REGULATOR receiver
D1822_RS16820	COG1722	exodeoxyribonuclease VII activity
D1822_RS16825	COG0142	geranyltranstransferase activity
D1822_RS16830	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
D1822_RS16855	COG1960	acyl-CoA dehydrogenase activity
D1822_RS16865	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
D1822_RS16870	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D1822_RS16875	COG0776	regulation of translation
D1822_RS16885	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D1822_RS16890	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D1822_RS16900	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
D1822_RS16905	COG1063	alcohol dehydrogenase
D1822_RS16910	COG0156	8-amino-7-oxononanoate synthase activity
D1822_RS16915	COG1396	sequence-specific DNA binding
D1822_RS16920	COG0183	Belongs to the thiolase family
D1822_RS16930	COG1176	ABC-type spermidine putrescine transport system, permease component I
D1822_RS16940	COG3842	ATPase activity
D1822_RS16950	COG1802	Transcriptional regulator
D1822_RS16960	COG3842	ATPase activity
D1822_RS16965	COG1176	ABC-type spermidine putrescine transport system, permease component I
D1822_RS16970	COG1177	transmembrane transport
D1822_RS16980	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D1822_RS16990	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
D1822_RS16995	COG1218	3'(2'),5'-bisphosphate nucleotidase
D1822_RS17010	COG0443	Heat shock 70 kDa protein
D1822_RS17015	COG0484	heat shock protein binding
D1822_RS17020	COG2003	Belongs to the UPF0758 family
D1822_RS17035	COG0653	protein targeting
D1822_RS17040	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D1822_RS17045	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
D1822_RS17050	COG0494	nUDIX hydrolase
D1822_RS17055	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
D1822_RS17070	COG0779	Required for maturation of 30S ribosomal subunits
D1822_RS17085	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D1822_RS17095	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D1822_RS17105	COG1040	competence protein
D1822_RS17120	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D1822_RS17140	COG3034	peptidoglycan biosynthetic process
D1822_RS17150	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D1822_RS17155	COG1132	(ABC) transporter
D1822_RS17160	COG1132	(ABC) transporter
D1822_RS17165	COG0617	tRNA 3'-terminal CCA addition
D1822_RS17170	COG0494	nUDIX hydrolase
D1822_RS17185	COG0745	RESPONSE REGULATOR receiver
D1822_RS17195	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D1822_RS17205	COG0137	argininosuccinate synthase activity
D1822_RS17230	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D1822_RS17240	COG0281	malic enzyme
D1822_RS17240	COG0280	phosphate acetyltransferase
D1822_RS17245	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
D1822_RS17250	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
D1822_RS17260	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
D1822_RS17265	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
D1822_RS17270	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D1822_RS17290	COG0357	Ribosomal RNA small subunit methyltransferase G
D1822_RS17295	COG0445	tRNA wobble uridine modification
D1822_RS17300	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
D1822_RS17305	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
D1822_RS17310	COG1981	membrane
D1822_RS17315	COG0424	maF-like protein
D1822_RS17320	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D1822_RS17325	COG0237	dephospho-CoA kinase activity
D1822_RS17330	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D1822_RS17335	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
D1822_RS17365	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
D1822_RS17375	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
D1822_RS17410	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
D1822_RS17415	COG3178	'Phosphotransferase
D1822_RS17420	COG0802	atpase or kinase
D1822_RS17435	COG1999	signal sequence binding
D1822_RS17440	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
D1822_RS17445	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
D1822_RS17455	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
D1822_RS17485	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
D1822_RS17490	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
D1822_RS17520	COG0318	PFAM AMP-dependent synthetase and ligase
D1822_RS17545	COG1706	bacterial-type flagellum-dependent cell motility
D1822_RS17550	COG1338	Plays a role in the flagellum-specific transport system
D1822_RS17555	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D1822_RS17565	COG1766	The M ring may be actively involved in energy transduction
D1822_RS17585	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
D1822_RS17600	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D1822_RS17610	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D1822_RS17625	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
D1822_RS17635	COG4786	Flagellar basal body rod
D1822_RS17640	COG4786	Flagellar basal body rod
D1822_RS17645	COG1987	bacterial-type flagellum assembly
D1822_RS17650	COG1677	Flagellar hook-basal body complex protein FliE
D1822_RS17655	COG1558	bacterial-type flagellum-dependent cell motility
D1822_RS17660	COG1815	bacterial-type flagellum-dependent cell motility
D1822_RS17670	COG5443	negative regulation of bacterial-type flagellum assembly
D1822_RS17680	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D1822_RS17700	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
D1822_RS17725	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D1822_RS17730	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
D1822_RS17735	COG1137	ATPase activity
D1822_RS17750	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
D1822_RS17750	COG0517	IMP dehydrogenase activity
D1822_RS17755	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
D1822_RS17780	COG1968	undecaprenyl-diphosphatase activity
D1822_RS17795	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D1822_RS17805	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D1822_RS17810	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D1822_RS17815	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
D1822_RS17820	COG0560	Phosphoserine phosphatase
D1822_RS17820	COG3830	Belongs to the UPF0237 family
D1822_RS17860	COG0820	rRNA (adenine-C2-)-methyltransferase activity
D1822_RS17880	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D1822_RS17890	COG2171	N-acyltransferase activity
D1822_RS17895	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
D1822_RS17905	COG2986	histidine ammonia-lyase
D1822_RS17910	COG1228	amidohydrolase
D1822_RS17930	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
D1822_RS17945	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D1822_RS17950	COG0557	exoribonuclease II activity
D1822_RS17965	COG2951	lytic endotransglycosylase activity
D1822_RS17975	COG2226	methyltransferase
D1822_RS17980	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D1822_RS17990	COG0268	Binds directly to 16S ribosomal RNA
D1822_RS17995	COG1192	Involved in chromosome partitioning
D1822_RS18015	COG1215	transferase activity, transferring glycosyl groups
D1822_RS18020	COG1215	transferase activity, transferring glycosyl groups
D1822_RS18040	COG1215	transferase activity, transferring glycosyl groups
D1822_RS18045	COG1215	transferase activity, transferring glycosyl groups
D1822_RS18050	COG0438	transferase activity, transferring glycosyl groups
D1822_RS18065	COG0840	transmembrane signaling receptor activity
D1822_RS18080	COG1522	sequence-specific DNA binding
D1822_RS18100	COG4948	Mandelate Racemase Muconate Lactonizing
D1822_RS18105	COG1012	belongs to the aldehyde dehydrogenase family
D1822_RS18115	COG0783	Belongs to the Dps family
D1822_RS18125	COG1802	Transcriptional regulator
D1822_RS18130	COG3938	Belongs to the proline racemase family
D1822_RS18140	COG0747	negative chemotaxis
D1822_RS18145	COG0601	transmembrane transport
D1822_RS18150	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D1822_RS18155	COG0444	Belongs to the ABC transporter superfamily
D1822_RS18160	COG4608	Belongs to the ABC transporter superfamily
D1822_RS18170	COG0840	transmembrane signaling receptor activity
D1822_RS18175	COG2244	polysaccharide biosynthetic process
D1822_RS18185	COG2017	converts alpha-aldose to the beta-anomer
D1822_RS18190	COG1858	cytochrome C peroxidase
D1822_RS18205	COG4213	ABC transporter substrate-binding protein
D1822_RS18210	COG4214	carbohydrate transport
D1822_RS18215	COG1129	ABC transporter
D1822_RS18220	COG0789	Transcriptional regulator
D1822_RS18240	COG1793	dna ligase
D1822_RS18250	COG0534	Mate efflux family protein
D1822_RS18260	COG1012	belongs to the aldehyde dehydrogenase family
D1822_RS18290	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D1822_RS18295	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D1822_RS18315	COG2951	lytic endotransglycosylase activity
D1822_RS18320	COG0740	serine-type endopeptidase activity
D1822_RS18330	COG1285	pathogenesis
D1822_RS18335	COG1366	Belongs to the anti-sigma-factor antagonist family
D1822_RS18340	COG1366	Belongs to the anti-sigma-factor antagonist family
D1822_RS18350	COG2172	sigma factor antagonist activity
D1822_RS18360	COG1473	amidohydrolase
D1822_RS18365	COG0133	tryptophan synthase activity
D1822_RS18370	COG1522	sequence-specific DNA binding
D1822_RS18415	COG1720	tRNA m6t6A37 methyltransferase activity
D1822_RS18420	COG0747	negative chemotaxis
D1822_RS18425	COG0601	transmembrane transport
D1822_RS18435	COG0444	Belongs to the ABC transporter superfamily
D1822_RS18440	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
D1822_RS18455	COG1960	acyl-CoA dehydrogenase activity
D1822_RS18475	COG0583	DNA-binding transcription factor activity
D1822_RS18480	COG0583	DNA-binding transcription factor activity
D1822_RS18485	COG4608	Belongs to the ABC transporter superfamily
D1822_RS18490	COG0444	Belongs to the ABC transporter superfamily
D1822_RS18495	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D1822_RS18500	COG0601	transmembrane transport
D1822_RS18505	COG0747	negative chemotaxis
D1822_RS18600	COG2010	Cytochrome c
D1822_RS18615	COG2132	Multicopper oxidase
D1822_RS18620	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D1822_RS18630	COG2207	Transcriptional regulator
D1822_RS18665	COG0583	DNA-binding transcription factor activity
D1822_RS18690	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
D1822_RS18705	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D1822_RS18715	COG1012	belongs to the aldehyde dehydrogenase family
D1822_RS18725	COG2207	Transcriptional regulator
D1822_RS18735	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D1822_RS18735	COG0446	pyridine nucleotide-disulphide oxidoreductase
D1822_RS18740	COG4311	Sarcosine oxidase, delta subunit
D1822_RS18745	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D1822_RS18755	COG1024	Enoyl-CoA hydratase
D1822_RS18760	COG1960	acyl-CoA dehydrogenase activity
D1822_RS18775	COG0735	belongs to the Fur family
D1822_RS18790	COG0577	efflux transmembrane transporter activity
D1822_RS18790	COG1136	(ABC) transporter
D1822_RS18815	COG0583	DNA-binding transcription factor activity
D1822_RS18840	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D1822_RS18845	COG0444	Belongs to the ABC transporter superfamily
D1822_RS18860	COG0596	Alpha beta hydrolase
D1822_RS18865	COG0251	oxidation-reduction process
D1822_RS18870	COG0583	DNA-binding transcription factor activity
D1822_RS18875	COG1012	belongs to the aldehyde dehydrogenase family
D1822_RS18895	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D1822_RS18900	COG0318	PFAM AMP-dependent synthetase and ligase
D1822_RS18905	COG1024	Enoyl-CoA hydratase
D1822_RS18910	COG1960	acyl-CoA dehydrogenase activity
D1822_RS18920	COG4948	Mandelate Racemase Muconate Lactonizing
D1822_RS18935	COG1902	pentaerythritol trinitrate reductase activity
D1822_RS18935	COG0446	pyridine nucleotide-disulphide oxidoreductase
D1822_RS18940	COG1902	pentaerythritol trinitrate reductase activity
D1822_RS18940	COG0446	pyridine nucleotide-disulphide oxidoreductase
D1822_RS18970	COG1024	Enoyl-CoA hydratase
D1822_RS18980	COG0583	DNA-binding transcription factor activity
D1822_RS19000	COG0789	Transcriptional regulator
D1822_RS19025	COG0745	RESPONSE REGULATOR receiver
D1822_RS19030	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
D1822_RS19045	COG0745	RESPONSE REGULATOR receiver
D1822_RS19055	COG0840	transmembrane signaling receptor activity
D1822_RS19060	COG2201	protein-glutamate methylesterase activity
D1822_RS19070	COG0725	ABC transporter, periplasmic molybdate-binding protein
D1822_RS19075	COG4149	molybdate abc transporter
D1822_RS19080	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
D1822_RS19100	COG0735	belongs to the Fur family
D1822_RS19110	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D1822_RS19125	COG3848	Pyruvate phosphate dikinase
D1822_RS19125	COG0574	Belongs to the PEP-utilizing enzyme family
D1822_RS19135	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
D1822_RS19165	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D1822_RS19190	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
D1822_RS19195	COG2132	Multicopper oxidase
D1822_RS19200	COG0583	DNA-binding transcription factor activity
D1822_RS19250	COG0673	inositol 2-dehydrogenase activity
D1822_RS19265	COG1653	transport
D1822_RS19270	COG1175	transmembrane transport
D1822_RS19280	COG3842	ATPase activity
D1822_RS19290	COG0673	inositol 2-dehydrogenase activity
D1822_RS19300	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D1822_RS19305	COG3002	Belongs to the UPF0753 family
D1822_RS19320	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
D1822_RS19325	COG1115	amino acid carrier protein
D1822_RS19330	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D1822_RS19335	COG0509	glycine decarboxylation via glycine cleavage system
D1822_RS19340	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D1822_RS19340	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D1822_RS19360	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D1822_RS19365	COG4604	ABC transporter, ATP-binding protein
D1822_RS19370	COG4605	iron ion homeostasis
D1822_RS19375	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D1822_RS19380	COG4607	ABC-type enterochelin transport system periplasmic component
D1822_RS19395	COG4264	IucA IucC family
D1822_RS19400	COG0318	PFAM AMP-dependent synthetase and ligase
D1822_RS19410	COG1082	Xylose isomerase domain protein TIM barrel
D1822_RS19415	COG1132	(ABC) transporter
D1822_RS19425	COG3177	Filamentation induced by cAMP protein fic
D1822_RS19430	COG2197	response regulator
D1822_RS19480	COG2205	protein histidine kinase activity
D1822_RS19495	COG1192	Involved in chromosome partitioning
D1822_RS19565	COG1126	abc transporter atp-binding protein
D1822_RS19580	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D1822_RS19590	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
D1822_RS19635	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
D1822_RS19655	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D1822_RS19665	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D1822_RS19670	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
D1822_RS19720	COG1216	Glycosyl transferase, family 2
D1822_RS19725	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D1822_RS19730	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
D1822_RS19740	COG1192	Involved in chromosome partitioning