locus-tag	class	description
PDPE_RS00020	COG3344	reverse transcriptase
PDPE_RS00025	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
PDPE_RS00035	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
PDPE_RS00055	COG1982	Orn Lys Arg decarboxylase major
PDPE_RS00080	COG1546	Belongs to the CinA family
PDPE_RS00080	COG1058	Belongs to the CinA family
PDPE_RS00085	COG0814	amino acid
PDPE_RS00105	COG0583	DNA-binding transcription factor activity
PDPE_RS00120	COG3344	reverse transcriptase
PDPE_RS00125	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
PDPE_RS00135	COG0616	signal peptide processing
PDPE_RS00140	COG1028	Short-chain dehydrogenase reductase Sdr
PDPE_RS00150	COG0009	L-threonylcarbamoyladenylate synthase
PDPE_RS00160	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
PDPE_RS00165	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
PDPE_RS00170	COG0512	Glutamine amidotransferase of anthranilate synthase
PDPE_RS00175	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
PDPE_RS00180	COG0135	phosphoribosylanthranilate isomerase activity
PDPE_RS00180	COG0134	indole-3-glycerol-phosphate synthase activity
PDPE_RS00185	COG0133	tryptophan synthase activity
PDPE_RS00190	COG0159	tryptophan synthase activity
PDPE_RS00195	COG2917	probably involved in intracellular septation
PDPE_RS00205	COG2350	Protein conserved in bacteria
PDPE_RS00215	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
PDPE_RS00225	COG0564	pseudouridine synthase activity
PDPE_RS00230	COG0733	neurotransmitter:sodium symporter activity
PDPE_RS00260	COG1454	alcohol dehydrogenase
PDPE_RS00275	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PDPE_RS00280	COG1609	Transcriptional regulator
PDPE_RS00285	COG3250	beta-galactosidase activity
PDPE_RS00290	COG2731	YhcH YjgK YiaL family protein
PDPE_RS00295	COG0531	amino acid
PDPE_RS00300	COG0531	amino acid
PDPE_RS00315	COG1794	racemase activity, acting on amino acids and derivatives
PDPE_RS00340	COG1511	domain protein
PDPE_RS00340	COG3264	Mechanosensitive ion channel
PDPE_RS00345	COG3243	poly(R)-hydroxyalkanoic acid synthase
PDPE_RS00355	COG0183	Belongs to the thiolase family
PDPE_RS00375	COG3279	Response regulator of the LytR AlgR family
PDPE_RS00380	COG3275	phosphorelay sensor kinase activity
PDPE_RS00400	COG3344	reverse transcriptase
PDPE_RS00445	COG1012	belongs to the aldehyde dehydrogenase family
PDPE_RS00475	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
PDPE_RS00505	COG1763	Mo-molybdopterin cofactor biosynthetic process
PDPE_RS00525	COG0494	nUDIX hydrolase
PDPE_RS00535	COG2897	thiosulfate sulfurtransferase activity
PDPE_RS00540	COG4989	oxidoreductase activity
PDPE_RS00565	COG2501	S4 domain
PDPE_RS00570	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
PDPE_RS00585	COG1879	ABC-type sugar transport system periplasmic component
PDPE_RS00595	COG1803	Methylglyoxal synthase
PDPE_RS00605	COG0210	DNA helicase
PDPE_RS00610	COG1289	transmembrane transporter activity
PDPE_RS00620	COG3344	reverse transcriptase
PDPE_RS00650	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
PDPE_RS00665	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PDPE_RS00665	COG4191	Histidine kinase
PDPE_RS00675	COG0617	tRNA 3'-terminal CCA addition
PDPE_RS00675	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
PDPE_RS00675	COG0517	IMP dehydrogenase activity
PDPE_RS00685	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PDPE_RS00685	COG4191	Histidine kinase
PDPE_RS00695	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PDPE_RS00700	COG0583	DNA-binding transcription factor activity
PDPE_RS00705	COG3070	regulator of competence-specific genes
PDPE_RS00720	COG2190	(PTS) system
PDPE_RS00720	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PDPE_RS00720	COG1263	PTS System
PDPE_RS00725	COG3344	reverse transcriptase
PDPE_RS00735	COG0470	DNA polymerase III
PDPE_RS00740	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
PDPE_RS00745	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
PDPE_RS00750	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
PDPE_RS00780	COG0416	fatty acid biosynthetic process
PDPE_RS00785	COG0333	Belongs to the bacterial ribosomal protein bL32 family
PDPE_RS00790	COG1399	metal-binding, possibly nucleic acid-binding protein
PDPE_RS00795	COG0424	maF-like protein
PDPE_RS00805	COG0564	pseudouridine synthase activity
PDPE_RS00810	COG1530	ribonuclease E activity
PDPE_RS00820	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
PDPE_RS00830	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
PDPE_RS00840	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
PDPE_RS00845	COG0517	IMP dehydrogenase activity
PDPE_RS00850	COG1295	ribonuclease BN
PDPE_RS00860	COG0717	Belongs to the dCTP deaminase family
PDPE_RS00865	COG0572	uridine kinase
PDPE_RS00870	COG0489	protein tyrosine kinase activity
PDPE_RS00875	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PDPE_RS00875	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PDPE_RS00900	COG1301	dicarboxylic acid transport
PDPE_RS00910	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
PDPE_RS00915	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
PDPE_RS00920	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
PDPE_RS00955	COG0492	ferredoxin-NADP+ reductase activity
PDPE_RS00960	COG4988	ABC transporter
PDPE_RS00965	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
PDPE_RS00970	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
PDPE_RS00980	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
PDPE_RS00985	COG0542	response to heat
PDPE_RS00990	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
PDPE_RS00995	COG1278	Cold shock
PDPE_RS01000	COG0538	isocitrate dehydrogenase activity
PDPE_RS01005	COG1187	pseudouridine synthase activity
PDPE_RS01010	COG0482	sulfurtransferase activity
PDPE_RS01015	COG2915	High frequency lysogenization protein hflD homolog
PDPE_RS01020	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
PDPE_RS01035	COG0426	domain, Protein
PDPE_RS01035	COG1773	rubredoxin
PDPE_RS01090	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PDPE_RS01095	COG0601	transmembrane transport
PDPE_RS01110	COG0314	molybdopterin synthase activity
PDPE_RS01115	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
PDPE_RS01120	COG0315	cyclic pyranopterin monophosphate synthase activity
PDPE_RS01140	COG0391	Required for morphogenesis under gluconeogenic growth conditions
PDPE_RS01145	COG2198	Histidine kinase
PDPE_RS01155	COG0556	nucleotide-excision repair
PDPE_RS01175	COG4657	Part of a membrane complex involved in electron transport
PDPE_RS01185	COG4656	Part of a membrane complex involved in electron transport
PDPE_RS01190	COG4658	electron transport chain
PDPE_RS01195	COG4659	FMN binding
PDPE_RS01200	COG4660	Part of a membrane complex involved in electron transport
PDPE_RS01205	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
PDPE_RS01240	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
PDPE_RS01245	COG2067	long-chain fatty acid transport protein
PDPE_RS01250	COG2267	carboxylic ester hydrolase activity
PDPE_RS01255	COG0450	alkyl hydroperoxide reductase
PDPE_RS01260	COG2056	Na+-H+ antiporter family
PDPE_RS01265	COG4568	rho-dependent transcription termination
PDPE_RS01270	COG3344	reverse transcriptase
PDPE_RS01275	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
PDPE_RS01285	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
PDPE_RS01290	COG1757	Na H antiporter
PDPE_RS01310	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
PDPE_RS01310	COG0674	pyruvate-flavodoxin oxidoreductase activity
PDPE_RS01310	COG1013	pyruvate-flavodoxin oxidoreductase activity
PDPE_RS01310	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PDPE_RS01315	COG0716	FMN binding
PDPE_RS01325	COG3081	Nucleoid-associated protein
PDPE_RS01330	COG3082	Protein of unknown function (DUF1414)
PDPE_RS01335	COG3083	sulfuric ester hydrolase activity
PDPE_RS01345	COG2203	Gaf domain
PDPE_RS01345	COG3706	GGDEF domain
PDPE_RS01345	COG4251	negative regulation of phosphorylation
PDPE_RS01345	COG5001	Diguanylate cyclase
PDPE_RS01360	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
PDPE_RS01395	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
PDPE_RS01400	COG0709	Synthesizes selenophosphate from selenide and ATP
PDPE_RS01405	COG0778	Nitroreductase
PDPE_RS01410	COG1902	pentaerythritol trinitrate reductase activity
PDPE_RS01410	COG0446	pyridine nucleotide-disulphide oxidoreductase
PDPE_RS01415	COG0616	signal peptide processing
PDPE_RS01420	COG0252	asparaginase activity
PDPE_RS01425	COG3139	Protein of unknown function (DUF1315)
PDPE_RS01435	COG3344	reverse transcriptase
PDPE_RS01445	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
PDPE_RS01450	COG0676	glucose-6-phosphate 1-epimerase activity
PDPE_RS01460	COG2766	serine protein kinase
PDPE_RS01465	COG2718	Belongs to the UPF0229 family
PDPE_RS01470	COG2719	SpoVR family
PDPE_RS01475	COG2186	Transcriptional regulator
PDPE_RS01480	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
PDPE_RS01485	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
PDPE_RS01490	COG0653	protein targeting
PDPE_RS01495	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
PDPE_RS01525	COG2983	Belongs to the UPF0260 family
PDPE_RS01560	COG1441	menaquinone biosynthetic process
PDPE_RS01565	COG0596	Alpha beta hydrolase
PDPE_RS01570	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
PDPE_RS01575	COG1169	isochorismate synthase
PDPE_RS01580	COG0436	Aminotransferase
PDPE_RS01585	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
PDPE_RS01590	COG0232	Belongs to the dGTPase family. Type 2 subfamily
PDPE_RS01620	COG1555	photosystem II stabilization
PDPE_RS01620	COG1596	polysaccharide export
PDPE_RS01625	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PDPE_RS01630	COG0776	regulation of translation
PDPE_RS01635	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
PDPE_RS01640	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
PDPE_RS01650	COG0544	peptidyl-prolyl cis-trans isomerase activity
PDPE_RS01665	COG1210	Utp--glucose-1-phosphate uridylyltransferase
PDPE_RS01680	COG0745	RESPONSE REGULATOR receiver
PDPE_RS01685	COG0583	DNA-binding transcription factor activity
PDPE_RS01690	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
PDPE_RS01695	COG1286	toxin biosynthetic process
PDPE_RS01700	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
PDPE_RS01705	COG0285	dihydrofolate synthase activity
PDPE_RS01710	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
PDPE_RS01715	COG0101	tRNA pseudouridine synthase activity
PDPE_RS01740	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
PDPE_RS01745	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PDPE_RS01755	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PDPE_RS01760	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
PDPE_RS01760	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PDPE_RS01800	COG3344	reverse transcriptase
PDPE_RS01810	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
PDPE_RS01815	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
PDPE_RS01825	COG3101	peptidyl-lysine hydroxylation
PDPE_RS01830	COG2860	membrane
PDPE_RS01835	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
PDPE_RS01840	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
PDPE_RS01840	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
PDPE_RS01840	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
PDPE_RS01855	COG2207	Transcriptional regulator
PDPE_RS01865	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
PDPE_RS01870	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PDPE_RS01905	COG0745	RESPONSE REGULATOR receiver
PDPE_RS01920	COG2261	transglycosylase associated protein
PDPE_RS01925	COG0708	Exodeoxyribonuclease III
PDPE_RS01930	COG1944	ATP diphosphatase activity
PDPE_RS01935	COG2116	formate transmembrane transporter activity
PDPE_RS01940	COG1882	Formate acetyltransferase
PDPE_RS01945	COG0826	peptidase U32
PDPE_RS01950	COG0826	peptidase U32
PDPE_RS01955	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
PDPE_RS01960	COG3344	reverse transcriptase
PDPE_RS02000	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
PDPE_RS02005	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
PDPE_RS02010	COG2226	methyltransferase
PDPE_RS02025	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
PDPE_RS02030	COG0857	belongs to the CobB CobQ family
PDPE_RS02030	COG0280	phosphate acetyltransferase
PDPE_RS02040	COG1090	epimerase
PDPE_RS02045	COG0300	oxidoreductase activity
PDPE_RS02050	COG3118	belongs to the thioredoxin family
PDPE_RS02060	COG2885	chlorophyll binding
PDPE_RS02060	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
PDPE_RS02065	COG3710	Transcriptional regulator
PDPE_RS02080	COG2217	Heavy metal translocating P-type atpase
PDPE_RS02085	COG3735	TraB family
PDPE_RS02090	COG2840	Smr protein MutS2
PDPE_RS02105	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
PDPE_RS02130	COG2877	3-deoxy-8-phosphooctulonate synthase activity
PDPE_RS02135	COG2912	Transglutaminase-like superfamily
PDPE_RS02140	COG3094	Invasion gene expression up-regulator, SirB
PDPE_RS02145	COG2890	protein-(glutamine-N5) methyltransferase activity
PDPE_RS02150	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
PDPE_RS02155	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
PDPE_RS02160	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
PDPE_RS02165	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
PDPE_RS02170	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
PDPE_RS02175	COG0193	aminoacyl-tRNA hydrolase activity
PDPE_RS02180	COG0012	GTP binding
PDPE_RS02265	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PDPE_RS02270	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
PDPE_RS02275	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
PDPE_RS02280	COG1702	phosphate starvation-inducible protein PhoH
PDPE_RS02285	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
PDPE_RS02290	COG4535	Mg2 and Co2 transporter CorC
PDPE_RS02295	COG0815	Transfers the fatty acyl group on membrane lipoproteins
PDPE_RS02310	COG2888	peptidyl-tyrosine sulfation
PDPE_RS02315	COG0495	leucyl-tRNA aminoacylation
PDPE_RS02325	COG1466	dna polymerase III delta subunit
PDPE_RS02330	COG0799	negative regulation of ribosome biogenesis
PDPE_RS02335	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
PDPE_RS02340	COG0768	penicillin binding
PDPE_RS02345	COG0772	Belongs to the SEDS family
PDPE_RS02350	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
PDPE_RS02360	COG1686	Belongs to the peptidase S11 family
PDPE_RS02370	COG0321	lipoyl(octanoyl) transferase activity
PDPE_RS02375	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
PDPE_RS02380	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
PDPE_RS02385	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PDPE_RS02390	COG2716	regulation of RNA biosynthetic process
PDPE_RS02405	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
PDPE_RS02420	COG4783	chaperone-mediated protein folding
PDPE_RS02425	COG1393	Belongs to the ArsC family
PDPE_RS02465	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PDPE_RS02475	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
PDPE_RS02480	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
PDPE_RS02485	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
PDPE_RS02490	COG0121	glutamine amidotransferase
PDPE_RS02500	COG0659	secondary active sulfate transmembrane transporter activity
PDPE_RS02520	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
PDPE_RS02525	COG0328	RNA-DNA hybrid ribonuclease activity
PDPE_RS02530	COG2226	methyltransferase
PDPE_RS02535	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PDPE_RS02540	COG0741	lytic transglycosylase activity
PDPE_RS02540	COG1388	LysM domain
PDPE_RS02600	COG0747	negative chemotaxis
PDPE_RS02605	COG4608	Belongs to the ABC transporter superfamily
PDPE_RS02610	COG0444	Belongs to the ABC transporter superfamily
PDPE_RS02615	COG4239	(ABC) transporter, permease
PDPE_RS02620	COG4174	ABC transporter (Permease)
PDPE_RS02630	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
PDPE_RS02635	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
PDPE_RS02645	COG1464	Belongs to the NlpA lipoprotein family
PDPE_RS02660	COG1720	tRNA m6t6A37 methyltransferase activity
PDPE_RS02665	COG0442	prolyl-tRNA aminoacylation
PDPE_RS02700	COG0814	amino acid
PDPE_RS02705	COG1181	Belongs to the D-alanine--D-alanine ligase family
PDPE_RS02710	COG0037	tRNA processing
PDPE_RS02715	COG0825	malonyl-CoA metabolic process
PDPE_RS02720	COG0587	DNA-directed DNA polymerase activity
PDPE_RS02725	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
PDPE_RS02730	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PDPE_RS02735	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PDPE_RS02740	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
PDPE_RS02745	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PDPE_RS02750	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
PDPE_RS02760	COG0750	zinc metalloprotease
PDPE_RS02765	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
PDPE_RS02770	COG0575	Belongs to the CDS family
PDPE_RS02775	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
PDPE_RS02780	COG0233	cytoplasmic translational termination
PDPE_RS02785	COG0528	UMP kinase activity
PDPE_RS02790	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
PDPE_RS02795	COG0052	Belongs to the universal ribosomal protein uS2 family
PDPE_RS02800	COG0024	Methionine aminopeptidase
PDPE_RS02805	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
PDPE_RS02815	COG0564	pseudouridine synthase activity
PDPE_RS02820	COG3098	single-species biofilm formation
PDPE_RS02865	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
PDPE_RS02875	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
PDPE_RS02875	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
PDPE_RS02915	COG1611	Belongs to the LOG family
PDPE_RS02920	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
PDPE_RS02925	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
PDPE_RS02930	COG2363	Small membrane protein
PDPE_RS02940	COG0583	DNA-binding transcription factor activity
PDPE_RS02945	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
PDPE_RS02950	COG2166	iron-sulfur cluster assembly
PDPE_RS02960	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
PDPE_RS02965	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
PDPE_RS02970	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
PDPE_RS02970	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
PDPE_RS02980	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
PDPE_RS02985	COG1074	ATP-dependent DNA helicase activity
PDPE_RS02990	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
PDPE_RS03000	COG0583	DNA-binding transcription factor activity
PDPE_RS03010	COG3141	response to X-ray
PDPE_RS03015	COG2171	N-acyltransferase activity
PDPE_RS03020	COG0531	amino acid
PDPE_RS03030	COG0076	glutamate decarboxylase activity
PDPE_RS03070	COG0542	response to heat
PDPE_RS03075	COG1496	oxidoreductase activity
PDPE_RS03085	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
PDPE_RS03090	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
PDPE_RS03095	COG1605	Chorismate mutase
PDPE_RS03095	COG0077	Prephenate dehydratase
PDPE_RS03100	COG1605	Chorismate mutase
PDPE_RS03100	COG0287	Prephenate dehydrogenase
PDPE_RS03105	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
PDPE_RS03115	COG3279	Response regulator of the LytR AlgR family
PDPE_RS03125	COG1966	Carbon starvation protein
PDPE_RS03135	COG0335	large ribosomal subunit rRNA binding
PDPE_RS03140	COG0336	Belongs to the RNA methyltransferase TrmD family
PDPE_RS03145	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
PDPE_RS03150	COG0228	four-way junction DNA binding
PDPE_RS03155	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
PDPE_RS03160	COG4137	Cytochrome C assembly protein
PDPE_RS03165	COG4536	flavin adenine dinucleotide binding
PDPE_RS03170	COG1854	S-ribosylhomocysteine lyase activity
PDPE_RS03180	COG2918	glutathione biosynthetic process
PDPE_RS03185	COG0612	Peptidase, M16
PDPE_RS03195	COG0604	alcohol dehydrogenase
PDPE_RS03195	COG3321	synthase
PDPE_RS03260	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
PDPE_RS03265	COG0527	aspartate kinase activity
PDPE_RS03270	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
PDPE_RS03275	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
PDPE_RS03300	COG1546	Belongs to the CinA family
PDPE_RS03305	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
PDPE_RS03310	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
PDPE_RS03315	COG4942	peptidase
PDPE_RS03315	COG1388	LysM domain
PDPE_RS03320	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
PDPE_RS03325	COG0585	pseudouridine synthase activity
PDPE_RS03330	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
PDPE_RS03335	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
PDPE_RS03345	COG0148	phosphopyruvate hydratase activity
PDPE_RS03350	COG0504	CTP synthase activity
PDPE_RS03355	COG3956	TIGRFAM MazG family protein
PDPE_RS03360	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
PDPE_RS03365	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
PDPE_RS03370	COG3850	Histidine kinase
PDPE_RS03370	COG2205	protein histidine kinase activity
PDPE_RS03370	COG4999	Histidine kinase
PDPE_RS03370	COG3437	response regulator, receiver
PDPE_RS03375	COG0736	holo-[acyl-carrier-protein] synthase activity
PDPE_RS03380	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
PDPE_RS03385	COG1381	Involved in DNA repair and RecF pathway recombination
PDPE_RS03390	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
PDPE_RS03395	COG0571	ribonuclease III activity
PDPE_RS03405	COG0481	GTPase activity
PDPE_RS03410	COG3086	response to oxidative stress
PDPE_RS03425	COG1595	DNA-templated transcription, initiation
PDPE_RS03430	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
PDPE_RS03440	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
PDPE_RS03445	COG0354	folic acid binding
PDPE_RS03460	COG0583	DNA-binding transcription factor activity
PDPE_RS03465	COG2991	Protein conserved in bacteria
PDPE_RS03475	COG1342	Belongs to the UPF0251 family
PDPE_RS03485	COG0509	glycine decarboxylation via glycine cleavage system
PDPE_RS03490	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PDPE_RS03495	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PDPE_RS03515	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
PDPE_RS03525	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
PDPE_RS03535	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PDPE_RS03550	COG0668	transmembrane transport
PDPE_RS03560	COG0126	phosphoglycerate kinase activity
PDPE_RS03575	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
PDPE_RS03590	COG2356	endonuclease I
PDPE_RS03595	COG1385	rRNA (uridine-N3-)-methyltransferase activity
PDPE_RS03600	COG0189	ligase activity
PDPE_RS03605	COG1678	Uncharacterized ACR, COG1678
PDPE_RS03610	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
PDPE_RS03625	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
PDPE_RS03630	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
PDPE_RS03635	COG0762	integral membrane protein
PDPE_RS03640	COG1872	DUF167
PDPE_RS03645	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
PDPE_RS03650	COG0635	Involved in the biosynthesis of porphyrin-containing compound
PDPE_RS03660	COG2066	Belongs to the glutaminase family
PDPE_RS03665	COG0220	tRNA (guanine-N7-)-methyltransferase activity
PDPE_RS03670	COG1194	a g-specific adenine glycosylase
PDPE_RS03675	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
PDPE_RS03730	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
PDPE_RS03735	COG1643	Atp-dependent helicase
PDPE_RS03740	COG1489	DNA binding
PDPE_RS03745	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
PDPE_RS03750	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PDPE_RS03760	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
PDPE_RS03765	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
PDPE_RS03770	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
PDPE_RS03780	COG1131	(ABC) transporter
PDPE_RS03785	COG0288	reversible hydration of carbon dioxide
PDPE_RS03800	COG3842	ATPase activity
PDPE_RS03805	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
PDPE_RS03810	COG1840	ABC-type Fe3 transport system, periplasmic component
PDPE_RS03815	COG0004	ammonium transporteR
PDPE_RS03825	COG3112	Uncharacterised protein family (UPF0231)
PDPE_RS03830	COG3835	regulator
PDPE_RS03835	COG2610	gluconate transmembrane transporter activity
PDPE_RS03840	COG1929	Belongs to the glycerate kinase type-1 family
PDPE_RS03875	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PDPE_RS03880	COG0508	dehydrogenase complex catalyzes the overall conversion of
PDPE_RS03885	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
PDPE_RS03905	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
PDPE_RS03925	COG0237	dephospho-CoA kinase activity
PDPE_RS03930	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
PDPE_RS03940	COG0494	nUDIX hydrolase
PDPE_RS03945	COG3344	reverse transcriptase
PDPE_RS03960	COG0653	protein targeting
PDPE_RS03970	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
PDPE_RS03975	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
PDPE_RS03980	COG0849	cell division
PDPE_RS03985	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
PDPE_RS03990	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
PDPE_RS03995	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
PDPE_RS04005	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
PDPE_RS04010	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
PDPE_RS04015	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
PDPE_RS04020	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
PDPE_RS04025	COG0768	penicillin binding
PDPE_RS04030	COG3116	cell division
PDPE_RS04035	COG0275	rRNA processing
PDPE_RS04045	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
PDPE_RS04050	COG3107	peptidoglycan biosynthetic process
PDPE_RS04060	COG0792	nuclease activity
PDPE_RS04065	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
PDPE_RS04070	COG2823	Periplasmic or secreted lipoprotein
PDPE_RS04075	COG2969	positive regulation of protein catabolic process
PDPE_RS04080	COG0625	glutathione transferase activity
PDPE_RS04095	COG0723	plastoquinol--plastocyanin reductase activity
PDPE_RS04100	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
PDPE_RS04105	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
PDPE_RS04110	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
PDPE_RS04115	COG3105	Protein conserved in bacteria
PDPE_RS04120	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PDPE_RS04125	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PDPE_RS04130	COG3344	reverse transcriptase
PDPE_RS04135	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
PDPE_RS04140	COG5007	Belongs to the BolA IbaG family
PDPE_RS04150	COG2854	intermembrane phospholipid transfer
PDPE_RS04155	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
PDPE_RS04160	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
PDPE_RS04165	COG1127	ABC transporter
PDPE_RS04175	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
PDPE_RS04175	COG0517	IMP dehydrogenase activity
PDPE_RS04180	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
PDPE_RS04185	COG3117	lipopolysaccharide transmembrane transporter activity
PDPE_RS04190	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
PDPE_RS04195	COG1137	ATPase activity
PDPE_RS04205	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
PDPE_RS04215	COG1660	Displays ATPase and GTPase activities
PDPE_RS04220	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
PDPE_RS04225	COG2239	Acts as a magnesium transporter
PDPE_RS04230	COG0312	modulator of DNA gyrase
PDPE_RS04240	COG0312	modulator of DNA gyrase
PDPE_RS04250	COG3164	Protein of unknown function
PDPE_RS04260	COG0424	maF-like protein
PDPE_RS04265	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
PDPE_RS04270	COG1792	Involved in formation and maintenance of cell shape
PDPE_RS04275	COG1077	Cell shape determining protein MreB Mrl
PDPE_RS04340	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
PDPE_RS04410	COG0629	single-stranded DNA binding
PDPE_RS04415	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
PDPE_RS04425	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
PDPE_RS04430	COG0527	aspartate kinase activity
PDPE_RS04435	COG0646	methionine synthase
PDPE_RS04435	COG1410	methionine synthase
PDPE_RS04445	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
PDPE_RS04490	COG0438	transferase activity, transferring glycosyl groups
PDPE_RS04520	COG0297	glycogen (starch) synthase activity
PDPE_RS04520	COG0438	transferase activity, transferring glycosyl groups
PDPE_RS04525	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
PDPE_RS04565	COG0203	ribosomal protein L17
PDPE_RS04575	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
PDPE_RS04585	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
PDPE_RS04590	COG0257	Belongs to the bacterial ribosomal protein bL36 family
PDPE_RS04595	COG0201	protein transport
PDPE_RS04600	COG0200	Binds to the 23S rRNA
PDPE_RS04605	COG1841	ribosomal large subunit assembly
PDPE_RS04610	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
PDPE_RS04620	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
PDPE_RS04625	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
PDPE_RS04630	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
PDPE_RS04635	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
PDPE_RS04640	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
PDPE_RS04645	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
PDPE_RS04650	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
PDPE_RS04655	COG0255	Belongs to the universal ribosomal protein uL29 family
PDPE_RS04660	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
PDPE_RS04670	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
PDPE_RS04675	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
PDPE_RS04680	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
PDPE_RS04685	COG0089	rRNA binding
PDPE_RS04690	COG0088	Forms part of the polypeptide exit tunnel
PDPE_RS04695	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
PDPE_RS04700	COG0051	transcription antitermination factor activity, RNA binding
PDPE_RS04705	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
PDPE_RS04710	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
PDPE_RS04715	COG0049	tRNA binding
PDPE_RS04730	COG2923	Belongs to the DsrF TusC family
PDPE_RS04735	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
PDPE_RS04740	COG2964	Protein conserved in bacteria
PDPE_RS04745	COG0545	Peptidyl-prolyl cis-trans isomerase
PDPE_RS04755	COG2900	Belongs to the SlyX family
PDPE_RS04775	COG2249	NAD(P)H dehydrogenase (quinone) activity
PDPE_RS04780	COG0488	(ABC) transporter
PDPE_RS04790	COG3089	Belongs to the UPF0270 family
PDPE_RS04795	COG3954	Phosphoribulokinase
PDPE_RS04800	COG1765	OsmC-like protein
PDPE_RS04805	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PDPE_RS04830	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
PDPE_RS04860	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
PDPE_RS04865	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
PDPE_RS04875	COG0338	D12 class N6 adenine-specific DNA methyltransferase
PDPE_RS04885	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
PDPE_RS04890	COG0546	phosphoglycolate phosphatase activity
PDPE_RS04895	COG0180	Tryptophanyl-tRNA synthetase
PDPE_RS04915	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
PDPE_RS04925	COG1012	belongs to the aldehyde dehydrogenase family
PDPE_RS04950	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
PDPE_RS04950	COG0165	Argininosuccinate lyase
PDPE_RS04955	COG0137	argininosuccinate synthase activity
PDPE_RS04960	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
PDPE_RS04965	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
PDPE_RS04970	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
PDPE_RS04975	COG1695	Transcriptional regulator
PDPE_RS05025	COG0254	rRNA binding
PDPE_RS05030	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
PDPE_RS05035	COG1609	Transcriptional regulator
PDPE_RS05040	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
PDPE_RS05045	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
PDPE_RS05050	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
PDPE_RS05055	COG1575	Belongs to the MenA family. Type 1 subfamily
PDPE_RS05060	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
PDPE_RS05065	COG3074	FtsZ-dependent cytokinesis
PDPE_RS05070	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
PDPE_RS05075	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
PDPE_RS05080	COG1494	fructose-1,6-bisphosphatase
PDPE_RS05105	COG0205	6-phosphofructokinase activity
PDPE_RS05115	COG0745	RESPONSE REGULATOR receiver
PDPE_RS05125	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
PDPE_RS05130	COG1045	serine acetyltransferase
PDPE_RS05135	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
PDPE_RS05140	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
PDPE_RS05145	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
PDPE_RS05150	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
PDPE_RS05155	COG4942	peptidase
PDPE_RS05165	COG1560	Kdo2-lipid A biosynthetic process
PDPE_RS05205	COG0463	Glycosyl transferase, family 2
PDPE_RS05220	COG1519	Transferase
PDPE_RS05230	COG0859	PFAM glycosyl transferase family 9
PDPE_RS05255	COG3344	reverse transcriptase
PDPE_RS05260	COG0267	Belongs to the bacterial ribosomal protein bL33 family
PDPE_RS05265	COG0227	Belongs to the bacterial ribosomal protein bL28 family
PDPE_RS05270	COG2003	Belongs to the UPF0758 family
PDPE_RS05275	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
PDPE_RS05285	COG1309	transcriptional regulator
PDPE_RS05290	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
PDPE_RS05295	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
PDPE_RS05300	COG1561	YicC-like family, N-terminal region
PDPE_RS05320	COG4191	Histidine kinase
PDPE_RS05320	COG2205	protein histidine kinase activity
PDPE_RS05320	COG0745	RESPONSE REGULATOR receiver
PDPE_RS05335	COG0194	GDP metabolic process
PDPE_RS05340	COG1758	RNA polymerase activity
PDPE_RS05345	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
PDPE_RS05350	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PDPE_RS05355	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
PDPE_RS05360	COG2233	PERMEase
PDPE_RS05380	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
PDPE_RS05385	COG2183	response to ionizing radiation
PDPE_RS05395	COG0596	Alpha beta hydrolase
PDPE_RS05405	COG0316	Belongs to the HesB IscA family
PDPE_RS05405	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
PDPE_RS05410	COG3344	reverse transcriptase
PDPE_RS05420	COG0534	Mate efflux family protein
PDPE_RS05460	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
PDPE_RS05475	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
PDPE_RS05480	COG2937	Belongs to the GPAT DAPAT family
PDPE_RS05485	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
PDPE_RS05490	COG3161	chorismate lyase activity
PDPE_RS05495	COG1580	Controls the rotational direction of flagella during chemotaxis
PDPE_RS05500	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
PDPE_RS05505	COG1349	DNA-binding transcription factor activity
PDPE_RS05510	COG2271	Major facilitator Superfamily
PDPE_RS05520	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
PDPE_RS05530	COG2177	Part of the ABC transporter FtsEX involved in
PDPE_RS05535	COG2884	Cell division ATP-binding protein ftsE
PDPE_RS05540	COG0552	protein localization to endoplasmic reticulum
PDPE_RS05540	COG0552	protein localization to endoplasmic reticulum
PDPE_RS05545	COG0742	ribosomal rna small subunit methyltransferase
PDPE_RS05575	COG3344	reverse transcriptase
PDPE_RS05580	COG4221	oxidoreductase activity
PDPE_RS05600	COG0783	Belongs to the Dps family
PDPE_RS05605	COG1280	lysine exporter protein (LysE YggA)
PDPE_RS05610	COG2267	carboxylic ester hydrolase activity
PDPE_RS05615	COG0561	phosphatase activity
PDPE_RS05630	COG3148	PFAM DTW domain containing protein
PDPE_RS05650	COG0531	amino acid
PDPE_RS05670	COG1982	Orn Lys Arg decarboxylase major
PDPE_RS05685	COG0084	hydrolase, TatD family'
PDPE_RS05690	COG0805	protein transport
PDPE_RS05695	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
PDPE_RS05700	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
PDPE_RS05705	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
PDPE_RS05715	COG2226	methyltransferase
PDPE_RS05720	COG1322	Protein conserved in bacteria
PDPE_RS05735	COG0006	proline dipeptidase activity
PDPE_RS05740	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
PDPE_RS05745	COG2022	thiamine diphosphate biosynthetic process
PDPE_RS05755	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
PDPE_RS05760	COG0352	thiamine-phosphate diphosphorylase activity
PDPE_RS05770	COG0589	response to stress
PDPE_RS05775	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
PDPE_RS05815	COG1309	transcriptional regulator
PDPE_RS05820	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PDPE_RS05825	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PDPE_RS05835	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
PDPE_RS05840	COG0583	DNA-binding transcription factor activity
PDPE_RS05930	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
PDPE_RS05935	COG1739	Uncharacterized protein family UPF0029
PDPE_RS05940	COG1024	Enoyl-CoA hydratase
PDPE_RS05940	COG1250	3-hydroxyacyl-CoA dehydrogenase
PDPE_RS05945	COG0183	Belongs to the thiolase family
PDPE_RS05950	COG0604	alcohol dehydrogenase
PDPE_RS05965	COG0425	Belongs to the sulfur carrier protein TusA family
PDPE_RS05970	COG3344	reverse transcriptase
PDPE_RS05980	COG2119	membrane
PDPE_RS05985	COG2885	chlorophyll binding
PDPE_RS05990	COG0752	glycyl-tRNA synthetase alpha subunit
PDPE_RS05995	COG0751	glycine-tRNA ligase activity
PDPE_RS06000	COG3977	Valine--pyruvate aminotransferase
PDPE_RS06005	COG0187	DNA topoisomerase II activity
PDPE_RS06010	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
PDPE_RS06015	COG0592	DNA-directed DNA polymerase activity
PDPE_RS06020	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
PDPE_RS06050	COG0230	Belongs to the bacterial ribosomal protein bL34 family
PDPE_RS06065	COG0706	membrane insertase activity
PDPE_RS06095	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
PDPE_RS06100	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
PDPE_RS06105	COG0445	tRNA wobble uridine modification
PDPE_RS06110	COG0357	Ribosomal RNA small subunit methyltransferase G
PDPE_RS06115	COG1192	Involved in chromosome partitioning
PDPE_RS06120	COG1475	DNA binding
PDPE_RS06125	COG3312	ion transport
PDPE_RS06130	COG0356	it plays a direct role in the translocation of protons across the membrane
PDPE_RS06140	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
PDPE_RS06145	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
PDPE_RS06150	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
PDPE_RS06155	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
PDPE_RS06160	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
PDPE_RS06165	COG0355	proton-transporting ATP synthase activity, rotational mechanism
PDPE_RS06175	COG1349	DNA-binding transcription factor activity
PDPE_RS06180	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
PDPE_RS06215	COG0129	dihydroxy-acid dehydratase activity
PDPE_RS06225	COG3978	acetolactate synthase activity
PDPE_RS06335	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
PDPE_RS06340	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
PDPE_RS06350	COG3084	Protein conserved in bacteria
PDPE_RS06360	COG2186	Transcriptional regulator
PDPE_RS06365	COG1272	protein, Hemolysin III
PDPE_RS06400	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
PDPE_RS06405	COG0569	domain protein
PDPE_RS06420	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
PDPE_RS06420	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
PDPE_RS06425	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
PDPE_RS06430	COG0242	peptide deformylase activity
PDPE_RS06440	COG0758	DNA mediated transformation
PDPE_RS06445	COG2922	Belongs to the Smg family
PDPE_RS06450	COG0551	DNA topoisomerase type I activity
PDPE_RS06455	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
PDPE_RS06460	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
PDPE_RS06465	COG0009	L-threonylcarbamoyladenylate synthase
PDPE_RS06470	COG0408	coproporphyrinogen oxidase activity
PDPE_RS06475	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
PDPE_RS06485	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
PDPE_RS06545	COG0747	negative chemotaxis
PDPE_RS06550	COG0601	transmembrane transport
PDPE_RS06555	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PDPE_RS06565	COG3314	Sporulation integral membrane protein YlbJ
PDPE_RS06640	COG2801	Transposase and inactivated derivatives
PDPE_RS06655	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PDPE_RS06660	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
PDPE_RS06665	COG0339	signal peptide processing
PDPE_RS06670	COG2153	protein acetylation
PDPE_RS06685	COG0513	Belongs to the DEAD box helicase family
PDPE_RS06690	COG3118	belongs to the thioredoxin family
PDPE_RS06700	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
PDPE_RS06720	COG0589	response to stress
PDPE_RS06725	COG1528	Iron-storage protein
PDPE_RS06825	COG1278	Cold shock
PDPE_RS06840	COG2165	general secretion pathway protein
PDPE_RS06845	COG1522	sequence-specific DNA binding
PDPE_RS06855	COG0742	ribosomal rna small subunit methyltransferase
PDPE_RS06865	COG3071	HemY protein
PDPE_RS06870	COG2959	enzyme of heme biosynthesis
PDPE_RS06875	COG1587	Uroporphyrinogen-III synthase
PDPE_RS06890	COG1965	Belongs to the frataxin family
PDPE_RS06900	COG0019	diaminopimelate decarboxylase activity
PDPE_RS06905	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
PDPE_RS06915	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
PDPE_RS06920	COG1011	Hydrolase
PDPE_RS06925	COG0210	DNA helicase
PDPE_RS06945	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
PDPE_RS06950	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
PDPE_RS06950	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
PDPE_RS06965	COG0218	Necessary for normal cell division and for the maintenance of normal septation
PDPE_RS06975	COG3344	reverse transcriptase
PDPE_RS06985	COG3078	GTPase activator activity
PDPE_RS06995	COG0635	Involved in the biosynthesis of porphyrin-containing compound
PDPE_RS07000	COG2176	DNA-directed DNA polymerase activity
PDPE_RS07005	COG0517	IMP dehydrogenase activity
PDPE_RS07030	COG0174	glutamine synthetase
PDPE_RS07035	COG1217	gtp-binding protein TYPA
PDPE_RS07050	COG1295	ribonuclease BN
PDPE_RS07055	COG1490	D-aminoacyl-tRNA deacylase activity
PDPE_RS07060	COG0456	acetyltransferase
PDPE_RS07085	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
PDPE_RS07090	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
PDPE_RS07095	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
PDPE_RS07100	COG3031	protein transport across the cell outer membrane
PDPE_RS07110	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
PDPE_RS07115	COG1459	type II secretion system
PDPE_RS07120	COG2165	general secretion pathway protein
PDPE_RS07125	COG2165	general secretion pathway protein
PDPE_RS07130	COG2165	general secretion pathway protein
PDPE_RS07135	COG4795	General secretion pathway protein
PDPE_RS07140	COG3156	type II secretion system protein K
PDPE_RS07145	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
PDPE_RS07150	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
PDPE_RS07160	COG0494	nUDIX hydrolase
PDPE_RS07165	COG1218	3'(2'),5'-bisphosphate nucleotidase
PDPE_RS07170	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PDPE_RS07185	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
PDPE_RS07190	COG4206	TonB-dependent receptor
PDPE_RS07200	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
PDPE_RS07245	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PDPE_RS07255	COG0812	UDP-N-acetylmuramate dehydrogenase activity
PDPE_RS07265	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
PDPE_RS07290	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
PDPE_RS07295	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
PDPE_RS07310	COG0081	regulation of translation
PDPE_RS07315	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
PDPE_RS07320	COG0222	ribosome binding
PDPE_RS07325	COG0085	RNA polymerase activity
PDPE_RS07330	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
PDPE_RS07335	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
PDPE_RS07340	COG2816	NAD+ diphosphatase activity
PDPE_RS07345	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
PDPE_RS07375	COG1253	flavin adenine dinucleotide binding
PDPE_RS07390	COG0151	Belongs to the GarS family
PDPE_RS07395	COG0138	bifunctional purine biosynthesis protein purh
PDPE_RS07400	COG0789	Transcriptional regulator
PDPE_RS07435	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
PDPE_RS07445	COG3501	Rhs element vgr protein
PDPE_RS07495	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
PDPE_RS07505	COG2264	protein methyltransferase activity
PDPE_RS07510	COG4145	pantothenate transmembrane transporter activity
PDPE_RS07515	COG3924	membrane
PDPE_RS07530	COG3344	reverse transcriptase
PDPE_RS07535	COG0439	Biotin carboxylase
PDPE_RS07540	COG0511	ligase activity, forming carbon-carbon bonds
PDPE_RS07545	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
PDPE_RS07550	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PDPE_RS07575	COG2814	Major facilitator Superfamily
PDPE_RS07585	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PDPE_RS07590	COG2095	MarC family integral membrane protein
PDPE_RS07605	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
PDPE_RS07610	COG1027	Aspartate ammonia-lyase
PDPE_RS07620	COG0534	Mate efflux family protein
PDPE_RS07640	COG0328	RNA-DNA hybrid ribonuclease activity
PDPE_RS07660	COG3344	reverse transcriptase
PDPE_RS07665	COG0189	ligase activity
PDPE_RS07670	COG1509	lysine 2,3-aminomutase activity
PDPE_RS07675	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
PDPE_RS07680	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
PDPE_RS07685	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
PDPE_RS07690	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
PDPE_RS07695	COG1053	succinate dehydrogenase
PDPE_RS07700	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
PDPE_RS07715	COG0471	metal ion transport
PDPE_RS07720	COG0688	phosphatidylethanolamine metabolic process
PDPE_RS07725	COG1162	GTPase activity
PDPE_RS07730	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
PDPE_RS07795	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
PDPE_RS07805	COG0802	atpase or kinase
PDPE_RS07810	COG0860	N-Acetylmuramoyl-L-alanine amidase
PDPE_RS07815	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
PDPE_RS07820	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
PDPE_RS07830	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
PDPE_RS07835	COG0330	HflC and HflK could
PDPE_RS07840	COG0330	HflC and HflK could
PDPE_RS07845	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
PDPE_RS07850	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
PDPE_RS07855	COG3344	reverse transcriptase
PDPE_RS07860	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
PDPE_RS07865	COG1017	nitric oxide dioxygenase activity
PDPE_RS07865	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
PDPE_RS07870	COG1959	2 iron, 2 sulfur cluster binding
PDPE_RS07875	COG0557	exoribonuclease II activity
PDPE_RS07880	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PDPE_RS07885	COG0360	Binds together with S18 to 16S ribosomal RNA
PDPE_RS07890	COG2965	DNA replication, synthesis of RNA primer
PDPE_RS07900	COG0359	binds to the 23S rRNA
PDPE_RS07910	COG0305	Participates in initiation and elongation during chromosome replication
PDPE_RS07915	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
PDPE_RS07930	COG0432	Pfam Uncharacterised protein family UPF0047
PDPE_RS07935	COG0166	Belongs to the GPI family
PDPE_RS07940	COG1278	Cold shock
PDPE_RS07950	COG0735	belongs to the Fur family
PDPE_RS07960	COG3344	reverse transcriptase
PDPE_RS07980	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
PDPE_RS07985	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PDPE_RS07990	COG0175	sulfate reduction
PDPE_RS08005	COG0545	Peptidyl-prolyl cis-trans isomerase
PDPE_RS08010	COG3061	Opacity-associated protein A
PDPE_RS08020	COG1648	precorrin-2 dehydrogenase activity
PDPE_RS08020	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
PDPE_RS08035	COG0471	metal ion transport
PDPE_RS08035	COG0490	domain, Protein
PDPE_RS08040	COG0529	Catalyzes the synthesis of activated sulfate
PDPE_RS08045	COG1218	3'(2'),5'-bisphosphate nucleotidase
PDPE_RS08140	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
PDPE_RS08150	COG0729	surface antigen
PDPE_RS08160	COG3344	reverse transcriptase
PDPE_RS08165	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
PDPE_RS08170	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
PDPE_RS08175	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
PDPE_RS08180	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
PDPE_RS08185	COG0163	prenyltransferase activity
PDPE_RS08195	COG3344	reverse transcriptase
PDPE_RS08210	COG1438	arginine binding
PDPE_RS08225	COG0142	geranyltranstransferase activity
PDPE_RS08230	COG0261	This protein binds to 23S rRNA in the presence of protein L20
PDPE_RS08240	COG0697	spore germination
PDPE_RS08245	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
PDPE_RS08250	COG2966	Psort location CytoplasmicMembrane, score
PDPE_RS08255	COG3610	response to peptide
PDPE_RS08265	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
PDPE_RS08275	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
PDPE_RS08280	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PDPE_RS08285	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
PDPE_RS08290	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
PDPE_RS08295	COG0564	pseudouridine synthase activity
PDPE_RS08310	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
PDPE_RS08315	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
PDPE_RS08320	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
PDPE_RS08330	COG4143	(ABC) transporter
PDPE_RS08340	COG0066	3-isopropylmalate dehydratase activity
PDPE_RS08350	COG0473	3-isopropylmalate dehydrogenase activity
PDPE_RS08360	COG0583	DNA-binding transcription factor activity
PDPE_RS08365	COG1022	Amp-dependent synthetase and ligase
PDPE_RS08370	COG0028	Belongs to the TPP enzyme family
PDPE_RS08385	COG0469	pyruvate kinase activity
PDPE_RS08405	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
PDPE_RS08480	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
PDPE_RS08485	COG0358	DNA primase activity
PDPE_RS08490	COG1610	YqeY-like protein
PDPE_RS08495	COG0828	Belongs to the bacterial ribosomal protein bS21 family
PDPE_RS08500	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
PDPE_RS08505	COG3344	reverse transcriptase
PDPE_RS08515	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
PDPE_RS08520	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
PDPE_RS08525	COG1968	undecaprenyl-diphosphatase activity
PDPE_RS08530	COG0617	tRNA 3'-terminal CCA addition
PDPE_RS08535	COG3409	Peptidoglycan-binding domain 1 protein
PDPE_RS08535	COG3267	Type II secretory pathway component ExeA
PDPE_RS08545	COG4991	sh3 domain protein
PDPE_RS08550	COG0306	phosphate transporter
PDPE_RS08555	COG1392	Phosphate transport regulator
PDPE_RS08560	COG3025	triphosphatase activity
PDPE_RS08565	COG3344	reverse transcriptase
PDPE_RS08575	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
PDPE_RS08580	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
PDPE_RS08580	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
PDPE_RS08585	COG1538	Outer membrane efflux protein
PDPE_RS08590	COG0494	nUDIX hydrolase
PDPE_RS08595	COG3151	Protein conserved in bacteria
PDPE_RS08605	COG3150	esterase
PDPE_RS08620	COG0204	Acyl-transferase
PDPE_RS08625	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
PDPE_RS08630	COG0251	oxidation-reduction process
PDPE_RS08635	COG1438	arginine binding
PDPE_RS08640	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
PDPE_RS08645	COG0540	Belongs to the ATCase OTCase family
PDPE_RS08650	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
PDPE_RS08670	COG1288	antiporter activity
PDPE_RS08675	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
PDPE_RS08690	COG0525	valine-tRNA ligase activity
PDPE_RS08695	COG2927	DNA polymerase III (CHI subunit)
PDPE_RS08700	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
PDPE_RS08705	COG0795	lipopolysaccharide-transporting ATPase activity
PDPE_RS08710	COG0795	lipopolysaccharide-transporting ATPase activity
PDPE_RS08740	COG0444	Belongs to the ABC transporter superfamily
PDPE_RS08745	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PDPE_RS08755	COG0747	negative chemotaxis
PDPE_RS08765	COG2813	Specifically methylates the guanine in position
PDPE_RS08770	COG0628	permease
PDPE_RS08775	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
PDPE_RS08785	COG0316	Belongs to the HesB IscA family
PDPE_RS08790	COG0739	heme binding
PDPE_RS08795	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
PDPE_RS08805	COG2860	membrane
PDPE_RS08820	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
PDPE_RS08825	COG0493	'glutamate synthase
PDPE_RS08830	COG0067	glutamate synthase
PDPE_RS08830	COG0070	glutamate synthase
PDPE_RS08830	COG0069	glutamate synthase activity
PDPE_RS08840	COG0067	glutamate synthase
PDPE_RS08840	COG0069	glutamate synthase activity
PDPE_RS08840	COG0070	glutamate synthase
PDPE_RS08845	COG1242	4 iron, 4 sulfur cluster binding
PDPE_RS08850	COG3706	GGDEF domain
PDPE_RS08850	COG4251	negative regulation of phosphorylation
PDPE_RS08850	COG2203	Gaf domain
PDPE_RS08850	COG5001	Diguanylate cyclase
PDPE_RS08855	COG5002	protein histidine kinase activity
PDPE_RS08855	COG2198	Histidine kinase
PDPE_RS08855	COG0784	Response regulator, receiver
PDPE_RS08870	COG0745	RESPONSE REGULATOR receiver
PDPE_RS08875	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
PDPE_RS08885	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
PDPE_RS08900	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
PDPE_RS08990	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
PDPE_RS09045	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
PDPE_RS09080	COG1115	amino acid carrier protein
PDPE_RS09085	COG3022	response to hydroperoxide
PDPE_RS09090	COG0513	Belongs to the DEAD box helicase family
PDPE_RS09110	COG4974	Belongs to the 'phage' integrase family
PDPE_RS09120	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
PDPE_RS09130	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
PDPE_RS09150	COG3066	DNA modification
PDPE_RS09155	COG0494	nUDIX hydrolase
PDPE_RS09165	COG0730	response to heat
PDPE_RS09170	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
PDPE_RS09175	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
PDPE_RS09180	COG1283	sodium-dependent phosphate transmembrane transporter activity
PDPE_RS09185	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
PDPE_RS09195	COG0583	DNA-binding transcription factor activity
PDPE_RS09200	COG0640	Transcriptional regulator
PDPE_RS09205	COG0268	Binds directly to 16S ribosomal RNA
PDPE_RS09210	COG0728	peptidoglycan biosynthetic process
PDPE_RS09215	COG0196	riboflavin kinase activity
PDPE_RS09220	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
PDPE_RS09225	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
PDPE_RS09230	COG1047	Peptidyl-prolyl cis-trans
PDPE_RS09235	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
PDPE_RS09245	COG0505	Belongs to the CarA family
PDPE_RS09250	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
PDPE_RS09265	COG2239	Acts as a magnesium transporter
PDPE_RS09270	COG2027	D-alanyl-D-alanine carboxypeptidase
PDPE_RS09275	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
PDPE_RS09285	COG1534	Rna-binding protein
PDPE_RS09290	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
PDPE_RS09295	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PDPE_RS09300	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
PDPE_RS09305	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PDPE_RS09310	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
PDPE_RS09325	COG0779	Required for maturation of 30S ribosomal subunits
PDPE_RS09330	COG0195	Participates in both transcription termination and antitermination
PDPE_RS09335	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
PDPE_RS09340	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
PDPE_RS09345	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
PDPE_RS09350	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
PDPE_RS09365	COG0826	peptidase U32
PDPE_RS09370	COG0826	peptidase U32
PDPE_RS09380	COG3154	lipid carrier protein
PDPE_RS09385	COG3153	acetyltransferase
PDPE_RS09390	COG0371	Dehydrogenase
PDPE_RS09405	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
PDPE_RS09415	COG0084	hydrolase, TatD family'
PDPE_RS09430	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
PDPE_RS09435	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
PDPE_RS09440	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
PDPE_RS09455	COG0560	Phosphoserine phosphatase
PDPE_RS09465	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
PDPE_RS09470	COG0739	heme binding
PDPE_RS09475	COG0488	(ABC) transporter
PDPE_RS09485	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
PDPE_RS09490	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
PDPE_RS09500	COG4932	domain protein
PDPE_RS09500	COG5492	domain, Protein
PDPE_RS09550	COG0513	Belongs to the DEAD box helicase family
PDPE_RS09575	COG2963	transposase activity
PDPE_RS09580	COG0326	Molecular chaperone. Has ATPase activity
PDPE_RS09605	COG0582	viral genome integration into host DNA
PDPE_RS09620	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
PDPE_RS09660	COG0582	viral genome integration into host DNA
PDPE_RS09670	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
PDPE_RS09675	COG2867	negative regulation of translational initiation
PDPE_RS09680	COG2914	Belongs to the UPF0125 (RnfH) family
PDPE_RS09685	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
PDPE_RS09690	COG0497	DNA recombination
PDPE_RS09695	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
PDPE_RS09700	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
PDPE_RS09705	COG0443	Heat shock 70 kDa protein
PDPE_RS09710	COG0484	heat shock protein binding
PDPE_RS09800	COG2390	Transcriptional regulator
PDPE_RS09810	COG3276	selenocysteine insertion sequence binding
PDPE_RS09825	COG2864	formate dehydrogenase
PDPE_RS09830	COG0437	4 iron, 4 sulfur cluster binding
PDPE_RS09835	COG3383	formate dehydrogenase (NAD+) activity
PDPE_RS09835	COG0243	molybdopterin cofactor binding
PDPE_RS09840	COG0243	molybdopterin cofactor binding
PDPE_RS09840	COG3383	formate dehydrogenase (NAD+) activity
PDPE_RS09845	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
PDPE_RS09860	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
PDPE_RS09865	COG0826	peptidase U32
PDPE_RS09870	COG0800	Aldolase
PDPE_RS09875	COG2818	Glycosylase
PDPE_RS09910	COG2974	May be involved in recombination
PDPE_RS09915	COG0420	3'-5' exonuclease activity
PDPE_RS09920	COG0419	ATPase involved in DNA repair
PDPE_RS09925	COG0745	RESPONSE REGULATOR receiver
PDPE_RS09940	COG0248	Ppx GppA phosphatase
PDPE_RS09945	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
PDPE_RS09960	COG0581	inorganic phosphate transmembrane transporter activity
PDPE_RS09965	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
PDPE_RS09970	COG0704	Plays a role in the regulation of phosphate uptake
PDPE_RS09985	COG3142	Participates in the control of copper homeostasis
PDPE_RS09990	COG0450	alkyl hydroperoxide reductase
PDPE_RS09995	COG0583	DNA-binding transcription factor activity
PDPE_RS10000	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
PDPE_RS10030	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
PDPE_RS10040	COG1862	Preprotein translocase
PDPE_RS10045	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
PDPE_RS10050	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
PDPE_RS10065	COG0483	inositol monophosphate 1-phosphatase activity
PDPE_RS10075	COG1959	2 iron, 2 sulfur cluster binding
PDPE_RS10080	COG1104	cysteine desulfurase activity
PDPE_RS10085	COG0822	iron-sulfur transferase activity
PDPE_RS10090	COG0316	Belongs to the HesB IscA family
PDPE_RS10095	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
PDPE_RS10100	COG0443	Heat shock 70 kDa protein
PDPE_RS10105	COG0633	Ferredoxin
PDPE_RS10110	COG2975	iron-sulfur cluster assembly
PDPE_RS10115	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
PDPE_RS10140	COG1426	Protein conserved in bacteria
PDPE_RS10145	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
PDPE_RS10150	COG0124	histidyl-tRNA synthetase
PDPE_RS10155	COG2976	Protein conserved in bacteria
PDPE_RS10160	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
PDPE_RS10165	COG1160	GTP binding
PDPE_RS10180	COG1570	exodeoxyribonuclease VII activity
PDPE_RS10185	COG0517	IMP dehydrogenase activity
PDPE_RS10185	COG0516	GMP reductase activity
PDPE_RS10190	COG0518	GMP synthase (glutamine-hydrolyzing) activity
PDPE_RS10190	COG0519	Catalyzes the synthesis of GMP from XMP
PDPE_RS10195	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
PDPE_RS10210	COG0583	DNA-binding transcription factor activity
PDPE_RS10250	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
PDPE_RS10255	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
PDPE_RS10260	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PDPE_RS10260	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PDPE_RS10275	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
PDPE_RS10280	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
PDPE_RS10285	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
PDPE_RS10290	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
PDPE_RS10320	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
PDPE_RS10325	COG0142	geranyltranstransferase activity
PDPE_RS10330	COG1722	exodeoxyribonuclease VII activity
PDPE_RS10345	COG1360	Flagellar Motor Protein
PDPE_RS10350	COG0301	tRNA thio-modification
PDPE_RS10350	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
PDPE_RS10355	COG0693	protein deglycase activity
PDPE_RS10360	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
PDPE_RS10365	COG3248	Nucleoside-binding outer membrane protein
PDPE_RS10380	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
PDPE_RS10390	COG2813	Specifically methylates the guanine in position
PDPE_RS10395	COG0271	Belongs to the BolA IbaG family
PDPE_RS10400	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
PDPE_RS10405	COG1805	sodium ion transport
PDPE_RS10415	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
PDPE_RS10420	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
PDPE_RS10425	COG2871	sodium ion transport
PDPE_RS10430	COG1477	protein flavinylation
PDPE_RS10440	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
PDPE_RS10445	COG2195	Cleaves the N-terminal amino acid of tripeptides
PDPE_RS10460	COG2252	PERMEase
PDPE_RS10465	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
PDPE_RS10470	COG1073	alpha beta
PDPE_RS10480	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
PDPE_RS10485	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
PDPE_RS10500	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
PDPE_RS10505	COG1393	Belongs to the ArsC family
PDPE_RS10515	COG2197	response regulator
PDPE_RS10525	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
PDPE_RS10525	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
PDPE_RS10545	COG3005	denitrification pathway
PDPE_RS10555	COG3344	reverse transcriptase
PDPE_RS10590	COG2837	iron assimilation
PDPE_RS10595	COG2190	(PTS) system
PDPE_RS10600	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
PDPE_RS10605	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
PDPE_RS10620	COG3115	cell septum assembly
PDPE_RS10625	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
PDPE_RS10640	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PDPE_RS10720	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
PDPE_RS10730	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
PDPE_RS10740	COG1516	flagellar protein fliS
PDPE_RS10750	COG3344	reverse transcriptase
PDPE_RS10770	COG1677	Flagellar hook-basal body complex protein FliE
PDPE_RS10780	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
PDPE_RS10830	COG1987	bacterial-type flagellum assembly
PDPE_RS10835	COG1684	flagellar biosynthetic protein fliR
PDPE_RS10880	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
PDPE_RS10885	COG0784	Response regulator, receiver
PDPE_RS10885	COG2198	Histidine kinase
PDPE_RS10885	COG0643	Histidine kinase
PDPE_RS10890	COG2201	protein-glutamate methylesterase activity
PDPE_RS10895	COG1192	Involved in chromosome partitioning
PDPE_RS10905	COG0835	chemotaxis
PDPE_RS10915	COG4133	protoheme IX ABC transporter activity
PDPE_RS10920	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
PDPE_RS10925	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
PDPE_RS10930	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
PDPE_RS10940	COG1138	Cytochrome C-type biogenesis protein
PDPE_RS10945	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PDPE_RS10965	COG2067	long-chain fatty acid transport protein
PDPE_RS10970	COG2067	long-chain fatty acid transport protein
PDPE_RS10990	COG0183	Belongs to the thiolase family
PDPE_RS10995	COG1024	Enoyl-CoA hydratase
PDPE_RS10995	COG1250	3-hydroxyacyl-CoA dehydrogenase
PDPE_RS11000	COG1025	Belongs to the peptidase M16 family
PDPE_RS11005	COG2062	phosphohistidine phosphatase, SixA
PDPE_RS11015	COG2840	Smr protein MutS2
PDPE_RS11020	COG2890	protein-(glutamine-N5) methyltransferase activity
PDPE_RS11025	COG3344	reverse transcriptase
PDPE_RS11030	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
PDPE_RS11040	COG1522	sequence-specific DNA binding
PDPE_RS11060	COG3126	Type III secretion system lipoprotein chaperone (YscW)
PDPE_RS11135	COG0778	Nitroreductase
PDPE_RS11140	COG0583	DNA-binding transcription factor activity
PDPE_RS11160	COG2814	Major facilitator Superfamily
PDPE_RS11165	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
PDPE_RS11205	COG0730	response to heat
PDPE_RS11215	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
PDPE_RS11220	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
PDPE_RS11230	COG2832	Protein of unknown function (DUF454)
PDPE_RS11235	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
PDPE_RS11240	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
PDPE_RS11245	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
PDPE_RS11250	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
PDPE_RS11270	COG0326	Molecular chaperone. Has ATPase activity
PDPE_RS11280	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
PDPE_RS11285	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PDPE_RS11290	COG0367	asparagine synthase
PDPE_RS11300	COG1846	Transcriptional regulator
PDPE_RS11300	COG1940	carbohydrate kinase activity
PDPE_RS11305	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
PDPE_RS11310	COG0363	glucosamine-6-phosphate deaminase activity
PDPE_RS11315	COG2190	(PTS) system
PDPE_RS11315	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PDPE_RS11315	COG1263	PTS System
PDPE_RS11325	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PDPE_RS11330	COG0735	belongs to the Fur family
PDPE_RS11340	COG0716	FMN binding
PDPE_RS11350	COG0596	Alpha beta hydrolase
PDPE_RS11355	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
PDPE_RS11360	COG0033	Phosphoglucomutase
PDPE_RS11375	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
PDPE_RS11400	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
PDPE_RS11405	COG0567	Dehydrogenase, E1 component
PDPE_RS11410	COG0508	dehydrogenase complex catalyzes the overall conversion of
PDPE_RS11420	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
PDPE_RS11425	COG1108	ABC-type Mn2 Zn2 transport systems permease components
PDPE_RS11430	COG1121	(ABC) transporter
PDPE_RS11435	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
PDPE_RS11470	COG0018	arginyl-trna synthetase
PDPE_RS11475	COG3102	Protein conserved in bacteria
PDPE_RS11480	COG0788	formyltetrahydrofolate deformylase activity
PDPE_RS11485	COG1199	ATP-dependent helicase activity
PDPE_RS11490	COG1214	PFAM Peptidase M22, glycoprotease
PDPE_RS11500	COG1073	alpha beta
PDPE_RS11500	COG2226	methyltransferase
PDPE_RS11505	COG0318	PFAM AMP-dependent synthetase and ligase
PDPE_RS11510	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
PDPE_RS11515	COG3344	reverse transcriptase
PDPE_RS11520	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
PDPE_RS11525	COG2894	cell division
PDPE_RS11530	COG0850	regulation of cytokinetic process
PDPE_RS11535	COG3100	YcgL domain-containing protein
PDPE_RS11540	COG2951	lytic endotransglycosylase activity
PDPE_RS11550	COG2916	Histone family protein nucleoid-structuring protein H-NS
PDPE_RS11560	COG1757	Na H antiporter
PDPE_RS11565	COG1435	thymidine kinase activity
PDPE_RS11570	COG4628	conserved protein (DUF2132)
PDPE_RS11580	COG0140	phosphoribosyl-ATP diphosphatase activity
PDPE_RS11580	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
PDPE_RS11585	COG0107	imidazoleglycerol-phosphate synthase activity
PDPE_RS11590	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
PDPE_RS11595	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
PDPE_RS11600	COG0131	Imidazoleglycerol-phosphate dehydratase
PDPE_RS11600	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
PDPE_RS11605	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
PDPE_RS11610	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
PDPE_RS11615	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
PDPE_RS11625	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
PDPE_RS11635	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PDPE_RS11640	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
PDPE_RS11645	COG0215	cysteine-tRNA ligase activity
PDPE_RS11650	COG0584	glycerophosphoryl diester phosphodiesterase
PDPE_RS11660	COG2095	MarC family integral membrane protein
PDPE_RS11680	COG0189	ligase activity
PDPE_RS11680	COG4067	protein conserved in archaea
PDPE_RS11685	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
PDPE_RS11690	COG2226	methyltransferase
PDPE_RS11705	COG0217	transcriptional regulatory protein
PDPE_RS11710	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
PDPE_RS11715	COG0632	four-way junction helicase activity
PDPE_RS11720	COG2255	four-way junction helicase activity
PDPE_RS11725	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PDPE_RS11730	COG1737	Transcriptional regulator
PDPE_RS11735	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
PDPE_RS11745	COG2731	YhcH YjgK YiaL family protein
PDPE_RS11750	COG1271	oxidase subunit
PDPE_RS11755	COG1294	oxidase, subunit
PDPE_RS11760	COG4890	Cyd operon protein YbgT
PDPE_RS11770	COG3344	reverse transcriptase
PDPE_RS11780	COG0811	peptide transport
PDPE_RS11785	COG0848	biopolymer transport protein
PDPE_RS11795	COG0823	Involved in the tonB-independent uptake of proteins
PDPE_RS11800	COG2885	chlorophyll binding
PDPE_RS11805	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
PDPE_RS11810	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
PDPE_RS11815	COG0784	Response regulator, receiver
PDPE_RS11815	COG2205	protein histidine kinase activity
PDPE_RS11875	COG2815	serine threonine protein kinase
PDPE_RS11875	COG0515	serine threonine protein kinase
PDPE_RS11905	COG3344	reverse transcriptase
PDPE_RS11940	COG0277	FAD linked oxidase domain protein
PDPE_RS11940	COG0247	lactate metabolic process
PDPE_RS11960	COG0583	DNA-binding transcription factor activity
PDPE_RS12060	COG3097	Belongs to the UPF0267 family
PDPE_RS12100	COG3069	C4-dicarboxylate transmembrane transporter activity
PDPE_RS12105	COG0583	DNA-binding transcription factor activity
PDPE_RS12115	COG0247	lactate metabolic process
PDPE_RS12120	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
PDPE_RS12125	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
PDPE_RS12155	COG0668	transmembrane transport
PDPE_RS12175	COG0583	DNA-binding transcription factor activity
PDPE_RS12180	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
PDPE_RS12190	COG3152	Membrane
PDPE_RS12215	COG0814	amino acid
PDPE_RS12230	COG0791	NLP P60 protein
PDPE_RS12230	COG1388	LysM domain
PDPE_RS12250	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
PDPE_RS12255	COG0363	glucosamine-6-phosphate deaminase activity
PDPE_RS12260	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
PDPE_RS12265	COG1115	amino acid carrier protein
PDPE_RS12280	COG4459	periplasmic nitrate reductase
PDPE_RS12285	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
PDPE_RS12300	COG0210	DNA helicase
PDPE_RS12305	COG1301	dicarboxylic acid transport
PDPE_RS12310	COG3791	Glutathione-dependent formaldehyde-activating
PDPE_RS12315	COG1252	NADH dehydrogenase
PDPE_RS12320	COG1252	NADH dehydrogenase
PDPE_RS12330	COG1914	H( )-stimulated, divalent metal cation uptake system
PDPE_RS12390	COG3527	Alpha-acetolactate decarboxylase
PDPE_RS12395	COG0028	Belongs to the TPP enzyme family
PDPE_RS12400	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PDPE_RS12410	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PDPE_RS12425	COG0463	Glycosyl transferase, family 2
PDPE_RS12440	COG0531	amino acid
PDPE_RS12500	COG0534	Mate efflux family protein
PDPE_RS12505	COG0307	riboflavin synthase, alpha
PDPE_RS12515	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
PDPE_RS12520	COG3001	Fructosamine kinase
PDPE_RS12525	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
PDPE_RS12535	COG0291	Belongs to the bacterial ribosomal protein bL35 family
PDPE_RS12540	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
PDPE_RS12545	COG3344	reverse transcriptase
PDPE_RS12555	COG3005	denitrification pathway
PDPE_RS12585	COG0730	response to heat
PDPE_RS12590	COG0583	DNA-binding transcription factor activity
PDPE_RS12605	COG2989	Protein conserved in bacteria
PDPE_RS12610	COG3108	Peptidase M15
PDPE_RS12630	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PDPE_RS12635	COG2197	response regulator
PDPE_RS12645	COG2271	Major facilitator Superfamily
PDPE_RS12650	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
PDPE_RS12670	COG1448	Aminotransferase
PDPE_RS12675	COG1024	Enoyl-CoA hydratase
PDPE_RS12680	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
PDPE_RS12725	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
PDPE_RS12730	COG0017	Asparaginyl-tRNA synthetase
PDPE_RS12735	COG0602	queuosine metabolic process
PDPE_RS12740	COG1940	carbohydrate kinase activity
PDPE_RS12745	COG0583	DNA-binding transcription factor activity
PDPE_RS12750	COG1556	Lactate utilization protein
PDPE_RS12760	COG1139	Iron-sulfur cluster binding protein
PDPE_RS12765	COG0247	lactate metabolic process
PDPE_RS12770	COG1620	l-lactate permease
PDPE_RS12815	COG0156	8-amino-7-oxononanoate synthase activity
PDPE_RS12820	COG2226	methyltransferase
PDPE_RS12825	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
PDPE_RS12860	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PDPE_RS12865	COG1131	(ABC) transporter
PDPE_RS12870	COG0842	Transport permease protein
PDPE_RS12945	COG1122	ATPase activity
PDPE_RS12950	COG4720	Psort location CytoplasmicMembrane, score
PDPE_RS12955	COG2197	response regulator
PDPE_RS12960	COG0322	excinuclease ABC activity
PDPE_RS13050	COG0010	Belongs to the arginase family
PDPE_RS13055	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
PDPE_RS13080	COG3209	COG3209 Rhs family protein
PDPE_RS13115	COG0732	type I restriction modification DNA specificity domain
PDPE_RS13135	COG1643	Atp-dependent helicase
PDPE_RS13155	COG3059	membrane
PDPE_RS13195	COG1686	Belongs to the peptidase S11 family
PDPE_RS13210	COG3501	Rhs element vgr protein
PDPE_RS13225	COG3070	regulator of competence-specific genes
PDPE_RS13230	COG1609	Transcriptional regulator
PDPE_RS13240	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PDPE_RS13250	COG0848	biopolymer transport protein
PDPE_RS13255	COG0811	peptide transport
PDPE_RS13260	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
PDPE_RS13270	COG3721	Heme iron utilization protein
PDPE_RS13275	COG0748	coenzyme F420 binding
PDPE_RS13300	COG0375	protein maturation
PDPE_RS13305	COG1214	PFAM Peptidase M22, glycoprotease
PDPE_RS13305	COG0456	acetyltransferase
PDPE_RS13310	COG2137	regulation of response to DNA damage stimulus
PDPE_RS13325	COG3381	protein complex oligomerization
PDPE_RS13335	COG3005	denitrification pathway
PDPE_RS13340	COG0745	RESPONSE REGULATOR receiver
PDPE_RS13370	COG0733	neurotransmitter:sodium symporter activity
PDPE_RS13375	COG0519	Catalyzes the synthesis of GMP from XMP
PDPE_RS13395	COG4667	esterase of the alpha-beta hydrolase superfamily
PDPE_RS13400	COG1227	inorganic diphosphatase activity
PDPE_RS13420	COG2731	YhcH YjgK YiaL family protein
PDPE_RS13440	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
PDPE_RS13445	COG2814	Major facilitator Superfamily
PDPE_RS13450	COG3099	Belongs to the UPF0263 family
PDPE_RS13455	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
PDPE_RS13475	COG3313	Fe-S protein
PDPE_RS13510	COG1061	Type III restriction enzyme res subunit
PDPE_RS13525	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PDPE_RS13550	COG0671	phosphoesterase, PA-phosphatase related
PDPE_RS13595	COG3344	reverse transcriptase
PDPE_RS13600	COG0303	'Molybdopterin
PDPE_RS13605	COG0746	molybdenum cofactor guanylyltransferase activity
PDPE_RS13610	COG3842	ATPase activity
PDPE_RS13625	COG2204	response regulator
PDPE_RS13630	COG3852	Histidine kinase
PDPE_RS13680	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
PDPE_RS13715	COG3148	PFAM DTW domain containing protein
PDPE_RS13720	COG1940	carbohydrate kinase activity
PDPE_RS13725	COG0513	Belongs to the DEAD box helicase family
PDPE_RS13735	COG0471	metal ion transport
PDPE_RS13740	COG3344	reverse transcriptase
PDPE_RS13745	COG2949	membrane
PDPE_RS13750	COG0281	malic enzyme
PDPE_RS13780	COG0500	methyltransferase
PDPE_RS13785	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
PDPE_RS13790	COG0697	spore germination
PDPE_RS13795	COG0295	cytidine deaminase activity
PDPE_RS13800	COG1346	cytolysis
PDPE_RS13805	COG1380	Effector of murein hydrolase LrgA
PDPE_RS13815	COG2925	Exonuclease
PDPE_RS13830	COG2926	Belongs to the UPF0265 family
PDPE_RS13835	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
PDPE_RS13835	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
PDPE_RS13865	COG3008	intermembrane lipid transfer
PDPE_RS13870	COG2995	paraquat-inducible protein a
PDPE_RS13875	COG1132	(ABC) transporter
PDPE_RS13880	COG1956	GAF domain-containing protein
PDPE_RS13885	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
PDPE_RS13900	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
PDPE_RS13905	COG0308	aminopeptidase N
PDPE_RS13915	COG0167	dihydroorotate dehydrogenase activity
PDPE_RS13925	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
PDPE_RS13925	COG0116	Belongs to the methyltransferase superfamily
PDPE_RS13935	COG0488	(ABC) transporter
PDPE_RS13950	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
PDPE_RS13955	COG1067	ATP-dependent peptidase activity
PDPE_RS13960	COG3120	sequence-specific DNA binding
PDPE_RS14000	COG2165	general secretion pathway protein
PDPE_RS14010	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
PDPE_RS14030	COG0784	Response regulator, receiver
PDPE_RS14030	COG5002	protein histidine kinase activity
PDPE_RS14050	COG3278	Belongs to the heme-copper respiratory oxidase family
PDPE_RS14065	COG2010	Cytochrome c
PDPE_RS14090	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PDPE_RS14095	COG0589	response to stress
PDPE_RS14100	COG3344	reverse transcriptase
PDPE_RS14125	COG1686	Belongs to the peptidase S11 family
PDPE_RS14130	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
PDPE_RS14145	COG5642	Protein of unknown function (DUF2384)
PDPE_RS14170	COG3842	ATPase activity
PDPE_RS14180	COG1177	transmembrane transport
PDPE_RS14185	COG3344	reverse transcriptase
PDPE_RS14190	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
PDPE_RS14195	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
PDPE_RS14220	COG0437	4 iron, 4 sulfur cluster binding
PDPE_RS14225	COG3383	formate dehydrogenase (NAD+) activity
PDPE_RS14225	COG3383	formate dehydrogenase (NAD+) activity
PDPE_RS14235	COG3381	protein complex oligomerization
PDPE_RS14255	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
PDPE_RS14265	COG4221	oxidoreductase activity
PDPE_RS14300	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
PDPE_RS14305	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PDPE_RS14310	COG4134	Bacterial extracellular solute-binding protein
PDPE_RS14320	COG4136	ATPase activity
PDPE_RS14325	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
PDPE_RS14330	COG0583	DNA-binding transcription factor activity
PDPE_RS14335	COG2814	Major facilitator Superfamily
PDPE_RS14340	COG1126	abc transporter atp-binding protein
PDPE_RS14345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PDPE_RS14365	COG4160	amino acid transport
PDPE_RS14395	COG3240	lipase activity
PDPE_RS14400	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
PDPE_RS14410	COG3344	reverse transcriptase
PDPE_RS14430	COG3300	MHYT domain
PDPE_RS14430	COG5001	Diguanylate cyclase
PDPE_RS14455	COG3344	reverse transcriptase
PDPE_RS14460	COG0786	glutamate:sodium symporter activity
PDPE_RS14470	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PDPE_RS14475	COG0670	Belongs to the BI1 family
PDPE_RS14480	COG2920	part of a sulfur-relay system
PDPE_RS14485	COG1254	Belongs to the acylphosphatase family
PDPE_RS14490	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
PDPE_RS14495	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
PDPE_RS14515	COG1335	isochorismatase
PDPE_RS14530	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
PDPE_RS14545	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
PDPE_RS14550	COG0640	Transcriptional regulator
PDPE_RS14575	COG3344	reverse transcriptase
PDPE_RS14580	COG2194	sulfuric ester hydrolase activity
PDPE_RS14655	COG0861	Integral membrane protein TerC family
PDPE_RS14660	COG2989	Protein conserved in bacteria
PDPE_RS14675	COG3344	reverse transcriptase
PDPE_RS14680	COG1328	CTP reductase activity
PDPE_RS14685	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
PDPE_RS14695	COG0302	gtp cyclohydrolase
PDPE_RS14715	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
PDPE_RS14750	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
PDPE_RS14765	COG1473	amidohydrolase
PDPE_RS14780	COG4181	ATPase activity
PDPE_RS14805	COG1671	Belongs to the UPF0178 family
PDPE_RS14815	COG0488	(ABC) transporter
PDPE_RS14835	COG1063	alcohol dehydrogenase
PDPE_RS14840	COG0156	8-amino-7-oxononanoate synthase activity
PDPE_RS14850	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
PDPE_RS14855	COG1619	proteins homologs of microcin C7 resistance protein MccF
PDPE_RS14865	COG0242	peptide deformylase activity
PDPE_RS14870	COG0784	Response regulator, receiver
PDPE_RS14870	COG2198	Histidine kinase
PDPE_RS14870	COG2205	protein histidine kinase activity
PDPE_RS14900	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
PDPE_RS14900	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
PDPE_RS14900	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
PDPE_RS14905	COG1105	Belongs to the carbohydrate kinase PfkB family
PDPE_RS14915	COG1609	Transcriptional regulator
PDPE_RS14925	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
PDPE_RS14940	COG1560	Kdo2-lipid A biosynthetic process
PDPE_RS14945	COG1560	Kdo2-lipid A biosynthetic process
PDPE_RS14950	COG0750	zinc metalloprotease
PDPE_RS14985	COG1131	(ABC) transporter
PDPE_RS14995	COG3719	Belongs to the RNase T2 family
PDPE_RS15005	COG1115	amino acid carrier protein
PDPE_RS15030	COG2207	Transcriptional regulator
PDPE_RS15030	COG3708	Transcriptional regulator
PDPE_RS15070	COG1115	amino acid carrier protein
PDPE_RS15145	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
PDPE_RS15150	COG4139	cobalamin transport
PDPE_RS15155	COG2988	succinylglutamate desuccinylase activity
PDPE_RS15160	COG0776	regulation of translation
PDPE_RS15165	COG3344	reverse transcriptase
PDPE_RS15170	COG0072	phenylalanine-tRNA ligase activity
PDPE_RS15170	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PDPE_RS15175	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
PDPE_RS15205	COG2990	Protein conserved in bacteria
PDPE_RS15215	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
PDPE_RS15220	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
PDPE_RS15225	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
PDPE_RS15240	COG3344	reverse transcriptase
PDPE_RS15250	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
PDPE_RS15255	COG2835	tetraacyldisaccharide 4'-kinase activity
PDPE_RS15260	COG1663	tetraacyldisaccharide 4'-kinase activity
PDPE_RS15265	COG1132	(ABC) transporter
PDPE_RS15270	COG0658	competence protein
PDPE_RS15270	COG2333	competence protein COMEC
PDPE_RS15280	COG2333	competence protein COMEC
PDPE_RS15280	COG0658	competence protein
PDPE_RS15310	COG3344	reverse transcriptase
PDPE_RS15315	COG4591	ABC-type transport system involved in lipoprotein release permease component
PDPE_RS15320	COG1136	(ABC) transporter
PDPE_RS15325	COG4591	ABC-type transport system involved in lipoprotein release permease component
PDPE_RS15335	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
PDPE_RS15375	COG1252	NADH dehydrogenase
PDPE_RS15415	COG0537	adenosine 5'-monophosphoramidase activity
PDPE_RS15425	COG0418	dihydroorotase activity
PDPE_RS15435	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PDPE_RS15450	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
PDPE_RS15460	COG0814	amino acid
PDPE_RS15465	COG1760	l-serine dehydratase
PDPE_RS15470	COG2207	Transcriptional regulator
PDPE_RS15485	COG1584	GPR1 FUN34 yaaH family protein
PDPE_RS15490	COG3344	reverse transcriptase
PDPE_RS15500	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
PDPE_RS15505	COG2985	domain, Protein
PDPE_RS15505	COG0569	domain protein
PDPE_RS15520	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
PDPE_RS15525	COG1960	acyl-CoA dehydrogenase activity
PDPE_RS15555	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PDPE_RS15565	COG1737	Transcriptional regulator
PDPE_RS15570	COG0469	pyruvate kinase activity
PDPE_RS15610	COG0583	DNA-binding transcription factor activity
PDPE_RS15615	COG3768	UPF0283 membrane protein
PDPE_RS15620	COG3106	COG3106 Predicted ATPase
PDPE_RS15645	COG1842	Phage shock protein A
PDPE_RS15650	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
PDPE_RS15660	COG4168	peptide transport system, permease
PDPE_RS15665	COG4171	peptide transport system, permease
PDPE_RS15675	COG4172	Belongs to the ABC transporter superfamily
PDPE_RS15700	COG0284	orotidine-5'-phosphate decarboxylase activity
PDPE_RS15705	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
PDPE_RS15710	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
PDPE_RS15715	COG0776	regulation of translation
PDPE_RS15720	COG0539	negative regulation of cytoplasmic translation
PDPE_RS15725	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
PDPE_RS15755	COG2205	protein histidine kinase activity
PDPE_RS15760	COG3040	lipid binding