locus-tag	class	description
VY86_RS00060	COG2885	chlorophyll binding
VY86_RS00100	COG1113	amino acid transport
VY86_RS00105	COG2988	succinylglutamate desuccinylase activity
VY86_RS00110	COG3724	N-succinylarginine dihydrolase activity
VY86_RS00115	COG1012	belongs to the aldehyde dehydrogenase family
VY86_RS00120	COG3138	arginine N-succinyltransferase
VY86_RS00125	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
VY86_RS00140	COG2175	clavaminate synthase activity
VY86_RS00145	COG1804	L-carnitine dehydratase bile acid-inducible protein F
VY86_RS00160	COG1917	Cupin 2, conserved barrel domain protein
VY86_RS00165	COG2814	Major facilitator Superfamily
VY86_RS00175	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
VY86_RS00185	COG1609	Transcriptional regulator
VY86_RS00195	COG3335	DDE superfamily endonuclease
VY86_RS00220	COG3335	DDE superfamily endonuclease
VY86_RS00240	COG2831	hemolysin activation secretion protein
VY86_RS00260	COG2831	hemolysin activation secretion protein
VY86_RS00275	COG2814	Major facilitator Superfamily
VY86_RS00280	COG1070	Carbohydrate kinase
VY86_RS00285	COG2390	Transcriptional regulator
VY86_RS00295	COG1830	Aldolase
VY86_RS00300	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
VY86_RS00335	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
VY86_RS00340	COG3675	Pfam Lipase (class 3)
VY86_RS00355	COG0625	glutathione transferase activity
VY86_RS00360	COG1090	epimerase
VY86_RS00370	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
VY86_RS00375	COG1286	toxin biosynthetic process
VY86_RS00380	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
VY86_RS00385	COG0285	dihydrofolate synthase activity
VY86_RS00390	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
VY86_RS00395	COG0586	Pfam SNARE associated Golgi protein
VY86_RS00400	COG0101	tRNA pseudouridine synthase activity
VY86_RS00405	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VY86_RS00410	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VY86_RS00415	COG2207	Transcriptional regulator
VY86_RS00420	COG0697	spore germination
VY86_RS00425	COG0642	Histidine kinase
VY86_RS00460	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VY86_RS00475	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
VY86_RS00475	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VY86_RS00485	COG3101	peptidyl-lysine hydroxylation
VY86_RS00490	COG0730	response to heat
VY86_RS00495	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
VY86_RS00500	COG2890	protein-(glutamine-N5) methyltransferase activity
VY86_RS00510	COG2986	histidine ammonia-lyase
VY86_RS00515	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
VY86_RS00525	COG0010	Belongs to the arginase family
VY86_RS00530	COG1228	amidohydrolase
VY86_RS00535	COG2840	Smr protein MutS2
VY86_RS00540	COG2062	phosphohistidine phosphatase, SixA
VY86_RS00545	COG1250	3-hydroxyacyl-CoA dehydrogenase
VY86_RS00545	COG1024	Enoyl-CoA hydratase
VY86_RS00550	COG0183	Belongs to the thiolase family
VY86_RS00555	COG2067	long-chain fatty acid transport protein
VY86_RS00570	COG0837	glucose binding
VY86_RS00600	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VY86_RS00620	COG3530	Putative quorum-sensing-regulated virulence factor
VY86_RS00625	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VY86_RS00630	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
VY86_RS00635	COG3115	cell septum assembly
VY86_RS00650	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VY86_RS00660	COG2190	(PTS) system
VY86_RS00665	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
VY86_RS00670	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
VY86_RS00675	COG4208	sulfate ABC transporter
VY86_RS00680	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
VY86_RS00685	COG4150	thiosulfate binding
VY86_RS00695	COG3111	PFAM Bacterial OB fold (BOF) protein
VY86_RS00700	COG0456	acetyltransferase
VY86_RS00705	COG0408	coproporphyrinogen oxidase activity
VY86_RS00720	COG1160	GTP binding
VY86_RS00725	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VY86_RS00730	COG2976	Protein conserved in bacteria
VY86_RS00735	COG0124	histidyl-tRNA synthetase
VY86_RS00740	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
VY86_RS00755	COG0820	rRNA (adenine-C2-)-methyltransferase activity
VY86_RS00760	COG0105	UTP biosynthetic process
VY86_RS00765	COG4953	penicillin-binding protein 1C
VY86_RS00770	COG2373	Large extracellular alpha-helical protein
VY86_RS00775	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VY86_RS00800	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
VY86_RS00805	COG2975	iron-sulfur cluster assembly
VY86_RS00810	COG0633	Ferredoxin
VY86_RS00815	COG0443	Heat shock 70 kDa protein
VY86_RS00820	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
VY86_RS00825	COG0316	Belongs to the HesB IscA family
VY86_RS00830	COG0822	iron-sulfur transferase activity
VY86_RS00835	COG1104	cysteine desulfurase activity
VY86_RS00840	COG1959	2 iron, 2 sulfur cluster binding
VY86_RS00845	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
VY86_RS00855	COG0366	Alpha amylase catalytic
VY86_RS00860	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VY86_RS00860	COG1263	PTS System
VY86_RS00870	COG2814	Major facilitator Superfamily
VY86_RS00875	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
VY86_RS00880	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VY86_RS00880	COG1017	nitric oxide dioxygenase activity
VY86_RS00885	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
VY86_RS00885	COG1073	alpha beta
VY86_RS00885	COG3064	Membrane
VY86_RS00885	COG1073	alpha beta
VY86_RS00885	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
VY86_RS00885	COG3064	Membrane
VY86_RS00905	COG1609	Transcriptional regulator
VY86_RS00910	COG1757	Na H antiporter
VY86_RS00915	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
VY86_RS00930	COG3423	Transcriptional regulator
VY86_RS00965	COG5433	transposase activity
VY86_RS01070	COG3501	Rhs element vgr protein
VY86_RS01085	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
VY86_RS01085	COG3064	Membrane
VY86_RS01085	COG1073	alpha beta
VY86_RS01095	COG2994	toxin metabolic process
VY86_RS01115	COG2274	protein secretion by the type I secretion system
VY86_RS01120	COG1917	Cupin 2, conserved barrel domain protein
VY86_RS01120	COG2207	Transcriptional regulator
VY86_RS01135	COG0735	belongs to the Fur family
VY86_RS01175	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VY86_RS01180	COG2190	(PTS) system
VY86_RS01180	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VY86_RS01180	COG1263	PTS System
VY86_RS01185	COG0363	glucosamine-6-phosphate deaminase activity
VY86_RS01190	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
VY86_RS01195	COG1940	carbohydrate kinase activity
VY86_RS01195	COG1846	Transcriptional regulator
VY86_RS01230	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VY86_RS01235	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
VY86_RS01240	COG1702	phosphate starvation-inducible protein PhoH
VY86_RS01245	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
VY86_RS01250	COG4535	Mg2 and Co2 transporter CorC
VY86_RS01255	COG0815	Transfers the fatty acyl group on membrane lipoproteins
VY86_RS01260	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
VY86_RS01270	COG0765	amino acid transport
VY86_RS01275	COG0765	amino acid transport
VY86_RS01280	COG1126	abc transporter atp-binding protein
VY86_RS01285	COG0495	leucyl-tRNA aminoacylation
VY86_RS01290	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
VY86_RS01295	COG1466	dna polymerase III delta subunit
VY86_RS01300	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
VY86_RS01305	COG0799	negative regulation of ribosome biogenesis
VY86_RS01310	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
VY86_RS01315	COG0768	penicillin binding
VY86_RS01320	COG0772	Belongs to the SEDS family
VY86_RS01325	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
VY86_RS01330	COG1686	Belongs to the peptidase S11 family
VY86_RS01335	COG2921	Belongs to the UPF0250 family
VY86_RS01340	COG0321	lipoyl(octanoyl) transferase activity
VY86_RS01345	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
VY86_RS01350	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
VY86_RS01360	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
VY86_RS01370	COG1780	Probably involved in ribonucleotide reductase function
VY86_RS01390	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VY86_RS01395	COG4175	Glycine betaine
VY86_RS01400	COG4176	ABC-type proline glycine betaine transport system permease component
VY86_RS01405	COG2113	Glycine betaine
VY86_RS01410	COG2814	Major facilitator Superfamily
VY86_RS01415	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
VY86_RS01425	COG1846	Transcriptional regulator
VY86_RS01430	COG1566	PFAM secretion protein HlyD family protein
VY86_RS01435	COG2814	Major facilitator Superfamily
VY86_RS01440	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VY86_RS01445	COG3148	PFAM DTW domain containing protein
VY86_RS01450	COG0045	succinate-CoA ligase (ADP-forming) activity
VY86_RS01450	COG1042	CoA-binding domain protein
VY86_RS01450	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VY86_RS01455	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VY86_RS01480	COG0542	response to heat
VY86_RS01485	COG1496	oxidoreductase activity
VY86_RS01490	COG0564	pseudouridine synthase activity
VY86_RS01495	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VY86_RS01500	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VY86_RS01510	COG1605	Chorismate mutase
VY86_RS01510	COG0077	Prephenate dehydratase
VY86_RS01525	COG0287	Prephenate dehydrogenase
VY86_RS01525	COG1605	Chorismate mutase
VY86_RS01530	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VY86_RS01540	COG0335	large ribosomal subunit rRNA binding
VY86_RS01545	COG0336	Belongs to the RNA methyltransferase TrmD family
VY86_RS01550	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
VY86_RS01555	COG0228	four-way junction DNA binding
VY86_RS01560	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
VY86_RS01565	COG4137	Cytochrome C assembly protein
VY86_RS01570	COG4536	flavin adenine dinucleotide binding
VY86_RS01575	COG1854	S-ribosylhomocysteine lyase activity
VY86_RS01580	COG2918	glutathione biosynthetic process
VY86_RS01605	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
VY86_RS01610	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
VY86_RS01615	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
VY86_RS01625	COG2814	Major facilitator Superfamily
VY86_RS01630	COG0318	PFAM AMP-dependent synthetase and ligase
VY86_RS01630	COG0204	Acyl-transferase
VY86_RS01635	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
VY86_RS01640	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
VY86_RS01645	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
VY86_RS01650	COG1073	alpha beta
VY86_RS01655	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
VY86_RS01660	COG2195	Cleaves the N-terminal amino acid of tripeptides
VY86_RS01700	COG4974	Belongs to the 'phage' integrase family
VY86_RS01705	COG0358	DNA primase activity
VY86_RS01710	COG3620	sequence-specific DNA binding
VY86_RS01745	COG4974	Belongs to the 'phage' integrase family
VY86_RS01750	COG0358	DNA primase activity
VY86_RS01755	COG3620	sequence-specific DNA binding
VY86_RS01810	COG1388	LysM domain
VY86_RS01810	COG0741	lytic transglycosylase activity
VY86_RS01880	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
VY86_RS01885	COG2867	negative regulation of translational initiation
VY86_RS01890	COG2914	Belongs to the UPF0125 (RnfH) family
VY86_RS01895	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VY86_RS01900	COG0497	DNA recombination
VY86_RS01905	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
VY86_RS01910	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
VY86_RS01920	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
VY86_RS01930	COG5433	transposase activity
VY86_RS02010	COG5433	transposase activity
VY86_RS02015	COG3335	DDE superfamily endonuclease
VY86_RS02020	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
VY86_RS02025	COG0736	holo-[acyl-carrier-protein] synthase activity
VY86_RS02030	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
VY86_RS02035	COG1381	Involved in DNA repair and RecF pathway recombination
VY86_RS02040	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
VY86_RS02045	COG0571	ribonuclease III activity
VY86_RS02050	COG0681	Belongs to the peptidase S26 family
VY86_RS02055	COG0481	GTPase activity
VY86_RS02060	COG3086	response to oxidative stress
VY86_RS02075	COG1595	DNA-templated transcription, initiation
VY86_RS02080	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
VY86_RS02085	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
VY86_RS02090	COG0513	Belongs to the DEAD box helicase family
VY86_RS02150	COG3335	DDE superfamily endonuclease
VY86_RS02160	COG1115	amino acid carrier protein
VY86_RS02165	COG1069	ribulokinase activity
VY86_RS02170	COG5433	transposase activity
VY86_RS02180	COG3206	protein involved in exopolysaccharide biosynthesis
VY86_RS02180	COG0489	protein tyrosine kinase activity
VY86_RS02195	COG5433	transposase activity
VY86_RS02200	COG0346	lactoylglutathione lyase activity
VY86_RS02325	COG4790	Type iii secretion
VY86_RS02330	COG4794	Type iii secretion
VY86_RS02335	COG4791	protein targeting
VY86_RS02340	COG4792	protein secretion
VY86_RS02410	COG1278	Cold shock
VY86_RS02445	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
VY86_RS02450	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
VY86_RS02455	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VY86_RS02460	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
VY86_RS02465	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VY86_RS02465	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VY86_RS02470	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
VY86_RS02475	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VY86_RS02480	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VY86_RS02485	COG1862	Preprotein translocase
VY86_RS02490	COG0343	queuine tRNA-ribosyltransferase activity
VY86_RS02495	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
VY86_RS02500	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
VY86_RS02505	COG0450	alkyl hydroperoxide reductase
VY86_RS02515	COG1114	Component of the transport system for branched-chain amino acids
VY86_RS02520	COG5002	protein histidine kinase activity
VY86_RS02525	COG0745	RESPONSE REGULATOR receiver
VY86_RS02530	COG0420	3'-5' exonuclease activity
VY86_RS02535	COG0419	ATPase involved in DNA repair
VY86_RS02555	COG1028	Short-chain dehydrogenase reductase Sdr
VY86_RS02560	COG1535	isochorismatase
VY86_RS02560	COG3433	isochorismatase activity
VY86_RS02565	COG1021	2,3-dihydroxybenzoate-AMP ligase
VY86_RS02570	COG1169	isochorismate synthase
VY86_RS02575	COG1120	ATPase activity
VY86_RS02585	COG1629	transport
VY86_RS02585	COG4774	siderophore transport
VY86_RS02590	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VY86_RS02595	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VY86_RS02600	COG4592	Periplasmic binding protein
VY86_RS02605	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
VY86_RS02610	COG0741	lytic transglycosylase activity
VY86_RS02610	COG1388	LysM domain
VY86_RS02615	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VY86_RS02620	COG2226	methyltransferase
VY86_RS02625	COG0328	RNA-DNA hybrid ribonuclease activity
VY86_RS02640	COG3423	Transcriptional regulator
VY86_RS02645	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
VY86_RS02660	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VY86_RS02665	COG0126	phosphoglycerate kinase activity
VY86_RS02680	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
VY86_RS02685	COG0142	geranyltranstransferase activity
VY86_RS02690	COG1722	exodeoxyribonuclease VII activity
VY86_RS02695	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VY86_RS02695	COG0301	tRNA thio-modification
VY86_RS02700	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
VY86_RS02705	COG1666	GTP binding
VY86_RS02710	COG2814	Major facilitator Superfamily
VY86_RS02715	COG0109	protoheme IX farnesyltransferase activity
VY86_RS02720	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
VY86_RS02725	COG1845	cytochrome c oxidase, subunit III
VY86_RS02730	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
VY86_RS02735	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
VY86_RS02745	COG2223	nitrite transmembrane transporter activity
VY86_RS02750	COG3056	Lipoprotein
VY86_RS02755	COG0271	Belongs to the BolA IbaG family
VY86_RS02760	COG0544	peptidyl-prolyl cis-trans isomerase activity
VY86_RS02770	COG0740	serine-type endopeptidase activity
VY86_RS02775	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
VY86_RS02780	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
VY86_RS02785	COG0776	regulation of translation
VY86_RS02790	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VY86_RS02795	COG1555	photosystem II stabilization
VY86_RS02800	COG0824	Thioesterase
VY86_RS02805	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
VY86_RS02815	COG1522	sequence-specific DNA binding
VY86_RS02820	COG1132	(ABC) transporter
VY86_RS02825	COG1132	(ABC) transporter
VY86_RS02830	COG0347	Belongs to the P(II) protein family
VY86_RS02835	COG0004	ammonium transporteR
VY86_RS02840	COG1946	Acyl-CoA thioesterase
VY86_RS02845	COG3126	Type III secretion system lipoprotein chaperone (YscW)
VY86_RS02855	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VY86_RS02860	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VY86_RS02865	COG1309	transcriptional regulator
VY86_RS02870	COG1122	ATPase activity
VY86_RS02875	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
VY86_RS02880	COG1268	BioY protein
VY86_RS02905	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
VY86_RS02910	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
VY86_RS02915	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
VY86_RS02920	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
VY86_RS02925	COG0326	Molecular chaperone. Has ATPase activity
VY86_RS02930	COG0563	adenylate kinase activity
VY86_RS02935	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
VY86_RS02940	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
VY86_RS02945	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VY86_RS02965	COG0561	phosphatase activity
VY86_RS02995	COG0583	DNA-binding transcription factor activity
VY86_RS03000	COG0583	DNA-binding transcription factor activity
VY86_RS03015	COG4651	solute:proton antiporter activity
VY86_RS03015	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
VY86_RS03020	COG2223	nitrite transmembrane transporter activity
VY86_RS03025	COG0737	Belongs to the 5'-nucleotidase family
VY86_RS03030	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
VY86_RS03035	COG3735	TraB family
VY86_RS03040	COG2217	Heavy metal translocating P-type atpase
VY86_RS03045	COG0789	Transcriptional regulator
VY86_RS03050	COG1585	Membrane protein implicated in regulation of membrane protease activity
VY86_RS03055	COG0330	HflC and HflK could
VY86_RS03060	COG3118	belongs to the thioredoxin family
VY86_RS03065	COG0300	oxidoreductase activity
VY86_RS03070	COG2755	lipolytic protein G-D-S-L family
VY86_RS03075	COG4181	ATPase activity
VY86_RS03080	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
VY86_RS03085	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
VY86_RS03100	COG0307	riboflavin synthase, alpha
VY86_RS03105	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
VY86_RS03110	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
VY86_RS03115	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VY86_RS03120	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VY86_RS03125	COG0215	cysteine-tRNA ligase activity
VY86_RS03130	COG2501	S4 domain
VY86_RS03135	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
VY86_RS03145	COG0582	viral genome integration into host DNA
VY86_RS03245	COG2932	Transcriptional regulator
VY86_RS03250	COG0358	DNA primase activity
VY86_RS03255	COG4974	Belongs to the 'phage' integrase family
VY86_RS03265	COG1802	Transcriptional regulator
VY86_RS03265	COG4626	Terminase
VY86_RS03270	COG3423	Transcriptional regulator
VY86_RS03285	COG3335	DDE superfamily endonuclease
VY86_RS03300	COG5433	transposase activity
VY86_RS03315	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
VY86_RS03315	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
VY86_RS03320	COG3433	isochorismatase activity
VY86_RS03320	COG2226	methyltransferase
VY86_RS03320	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
VY86_RS03345	COG2885	chlorophyll binding
VY86_RS03455	COG5433	transposase activity
VY86_RS03485	COG1595	DNA-templated transcription, initiation
VY86_RS03490	COG3712	iron ion homeostasis
VY86_RS03520	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
VY86_RS03540	COG1388	LysM domain
VY86_RS03540	COG4942	peptidase
VY86_RS03545	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
VY86_RS03550	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
VY86_RS03555	COG0585	pseudouridine synthase activity
VY86_RS03560	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
VY86_RS03565	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
VY86_RS03570	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
VY86_RS03580	COG2895	sulfate adenylyltransferase (ATP) activity
VY86_RS03585	COG0175	sulfate reduction
VY86_RS03590	COG1648	precorrin-2 dehydrogenase activity
VY86_RS03590	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
VY86_RS03600	COG1349	DNA-binding transcription factor activity
VY86_RS03610	COG2222	sugar isomerase
VY86_RS03615	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VY86_RS03620	COG3715	PTS system
VY86_RS03625	COG3716	PTS system mannose fructose sorbose family IID component
VY86_RS03650	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
VY86_RS03655	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
VY86_RS03695	COG2337	Toxic component of a toxin-antitoxin (TA) module
VY86_RS03705	COG0288	reversible hydration of carbon dioxide
VY86_RS03710	COG1131	(ABC) transporter
VY86_RS03715	COG0842	Transport permease protein
VY86_RS03720	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
VY86_RS03725	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
VY86_RS03730	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
VY86_RS03735	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VY86_RS03745	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VY86_RS03755	COG1489	DNA binding
VY86_RS03760	COG1643	Atp-dependent helicase
VY86_RS03765	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
VY86_RS03790	COG1396	sequence-specific DNA binding
VY86_RS03795	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
VY86_RS03805	COG0316	Belongs to the HesB IscA family
VY86_RS03825	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
VY86_RS03830	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
VY86_RS03850	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VY86_RS03855	COG3956	TIGRFAM MazG family protein
VY86_RS03865	COG4133	protoheme IX ABC transporter activity
VY86_RS03875	COG0504	CTP synthase activity
VY86_RS03880	COG0148	phosphopyruvate hydratase activity
VY86_RS03885	COG0471	metal ion transport
VY86_RS03900	COG1203	CRISPR-associated helicase, Cas3
VY86_RS03955	COG3675	Pfam Lipase (class 3)
VY86_RS03965	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
VY86_RS03970	COG5433	transposase activity
VY86_RS03975	COG3012	SEC-C Motif Domain Protein
VY86_RS03995	COG2194	sulfuric ester hydrolase activity
VY86_RS04000	COG0582	viral genome integration into host DNA
VY86_RS04005	COG3539	Fimbrial protein
VY86_RS04015	COG3188	usher protein
VY86_RS04020	COG3121	Chaperone
VY86_RS04030	COG3539	Fimbrial protein
VY86_RS04035	COG3539	Fimbrial protein
VY86_RS04045	COG1396	sequence-specific DNA binding
VY86_RS04050	COG0494	nUDIX hydrolase
VY86_RS04055	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
VY86_RS04070	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
VY86_RS04075	COG0814	amino acid
VY86_RS04080	COG2864	formate dehydrogenase
VY86_RS04085	COG0437	4 iron, 4 sulfur cluster binding
VY86_RS04090	COG3383	formate dehydrogenase (NAD+) activity
VY86_RS04090	COG0243	molybdopterin cofactor binding
VY86_RS04100	COG0534	Mate efflux family protein
VY86_RS04110	COG3033	Beta-eliminating lyase
VY86_RS04115	COG0814	amino acid
VY86_RS04120	COG5441	Belongs to the UPF0261 family
VY86_RS04145	COG3842	ATPase activity
VY86_RS04155	COG1840	ABC-type Fe3 transport system, periplasmic component
VY86_RS04160	COG2271	Major facilitator Superfamily
VY86_RS04175	COG0175	sulfate reduction
VY86_RS04180	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VY86_RS04185	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VY86_RS04190	COG0720	synthase
VY86_RS04195	COG0602	queuosine metabolic process
VY86_RS04205	COG3021	interspecies interaction between organisms
VY86_RS04235	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VY86_RS04240	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
VY86_RS04250	COG1464	Belongs to the NlpA lipoprotein family
VY86_RS04260	COG1720	tRNA m6t6A37 methyltransferase activity
VY86_RS04265	COG0442	prolyl-tRNA aminoacylation
VY86_RS04270	COG3015	lipoprotein NlpE involved in copper resistance
VY86_RS04275	COG4568	rho-dependent transcription termination
VY86_RS04295	COG5433	transposase activity
VY86_RS04305	COG2274	protein secretion by the type I secretion system
VY86_RS04310	COG5433	transposase activity
VY86_RS04345	COG0037	tRNA processing
VY86_RS04350	COG0825	malonyl-CoA metabolic process
VY86_RS04360	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
VY86_RS04365	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VY86_RS04380	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VY86_RS04395	COG0750	zinc metalloprotease
VY86_RS04400	COG0575	Belongs to the CDS family
VY86_RS04405	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
VY86_RS04410	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
VY86_RS04415	COG0233	cytoplasmic translational termination
VY86_RS04420	COG0528	UMP kinase activity
VY86_RS04425	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
VY86_RS04430	COG0052	Belongs to the universal ribosomal protein uS2 family
VY86_RS04440	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
VY86_RS04445	COG2171	N-acyltransferase activity
VY86_RS04465	COG0564	pseudouridine synthase activity
VY86_RS04470	COG3098	single-species biofilm formation
VY86_RS04530	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
VY86_RS04530	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
VY86_RS04535	COG1611	Belongs to the LOG family
VY86_RS04540	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VY86_RS04575	COG2363	Small membrane protein
VY86_RS04580	COG0583	DNA-binding transcription factor activity
VY86_RS04585	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
VY86_RS04590	COG2166	iron-sulfur cluster assembly
VY86_RS04595	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
VY86_RS04600	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
VY86_RS04625	COG0860	N-Acetylmuramoyl-L-alanine amidase
VY86_RS04630	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
VY86_RS04630	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
VY86_RS04635	COG3177	Filamentation induced by cAMP protein fic
VY86_RS04650	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
VY86_RS04665	COG2843	Capsule synthesis protein
VY86_RS04675	COG0151	Belongs to the GarS family
VY86_RS04680	COG0477	Major facilitator Superfamily
VY86_RS04685	COG0154	amidase activity
VY86_RS04690	COG1132	(ABC) transporter
VY86_RS04695	COG1132	(ABC) transporter
VY86_RS04695	COG2375	cellular response to nickel ion
VY86_RS04720	COG3433	isochorismatase activity
VY86_RS04720	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
VY86_RS04720	COG2226	methyltransferase
VY86_RS04730	COG4771	TonB-dependent receptor
VY86_RS04735	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
VY86_RS04740	COG1074	ATP-dependent DNA helicase activity
VY86_RS04745	COG1025	Belongs to the peptidase M16 family
VY86_RS04750	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
VY86_RS04765	COG4795	General secretion pathway protein
VY86_RS04785	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
VY86_RS04790	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
VY86_RS04800	COG0494	nUDIX hydrolase
VY86_RS04805	COG4143	(ABC) transporter
VY86_RS04810	COG1178	ABC-type Fe3 transport system permease component
VY86_RS04815	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
VY86_RS04835	COG0417	DNA replication proofreading
VY86_RS04840	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
VY86_RS04845	COG0564	pseudouridine synthase activity
VY86_RS04850	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
VY86_RS04855	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
VY86_RS04860	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VY86_RS04865	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
VY86_RS04870	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
VY86_RS04875	COG2967	ApaG domain
VY86_RS04880	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
VY86_RS04885	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
VY86_RS04895	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
VY86_RS04900	COG0505	Belongs to the CarA family
VY86_RS04905	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
VY86_RS04910	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
VY86_RS04915	COG1047	Peptidyl-prolyl cis-trans
VY86_RS04920	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
VY86_RS04925	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
VY86_RS04930	COG0196	riboflavin kinase activity
VY86_RS04935	COG0268	Binds directly to 16S ribosomal RNA
VY86_RS04940	COG0583	DNA-binding transcription factor activity
VY86_RS04945	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VY86_RS04950	COG1263	PTS System
VY86_RS04950	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VY86_RS04950	COG2190	(PTS) system
VY86_RS04955	COG3711	transcriptional antiterminator
VY86_RS04975	COG0484	heat shock protein binding
VY86_RS04980	COG0443	Heat shock 70 kDa protein
VY86_RS04985	COG1584	GPR1 FUN34 yaaH family protein
VY86_RS05005	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
VY86_RS05010	COG1085	galactose-1-phosphate uridylyltransferase
VY86_RS05020	COG3423	Transcriptional regulator
VY86_RS05040	COG2197	response regulator
VY86_RS05045	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VY86_RS05055	COG1012	belongs to the aldehyde dehydrogenase family
VY86_RS05080	COG2932	Transcriptional regulator
VY86_RS05085	COG0358	DNA primase activity
VY86_RS05095	COG4974	Belongs to the 'phage' integrase family
VY86_RS05140	COG3335	DDE superfamily endonuclease
VY86_RS05155	COG1785	Belongs to the alkaline phosphatase family
VY86_RS05160	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VY86_RS05180	COG3328	transposase activity
VY86_RS05185	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
VY86_RS05185	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VY86_RS05185	COG3321	synthase
VY86_RS05185	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VY86_RS05190	COG2192	nodulation
VY86_RS05200	COG2814	Major facilitator Superfamily
VY86_RS05225	COG2813	Specifically methylates the guanine in position
VY86_RS05230	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
VY86_RS05235	COG0456	acetyltransferase
VY86_RS05240	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
VY86_RS05245	COG2823	Periplasmic or secreted lipoprotein
VY86_RS05250	COG4667	esterase of the alpha-beta hydrolase superfamily
VY86_RS05255	COG0084	hydrolase, TatD family'
VY86_RS05260	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VY86_RS05265	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
VY86_RS05270	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
VY86_RS05275	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
VY86_RS05280	COG0813	purine-nucleoside phosphorylase activity
VY86_RS05285	COG0626	cystathionine gamma-synthase activity
VY86_RS05300	COG3726	membrane protein affecting hemolysin expression
VY86_RS05305	COG0560	Phosphoserine phosphatase
VY86_RS05310	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
VY86_RS05320	COG1136	(ABC) transporter
VY86_RS05325	COG0488	(ABC) transporter
VY86_RS05330	COG0741	lytic transglycosylase activity
VY86_RS05335	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
VY86_RS05340	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
VY86_RS05345	COG0406	alpha-ribazole phosphatase activity
VY86_RS05350	COG3708	Transcriptional regulator
VY86_RS05350	COG2207	Transcriptional regulator
VY86_RS05355	COG3045	CreA protein
VY86_RS05360	COG0745	RESPONSE REGULATOR receiver
VY86_RS05370	COG0083	homoserine kinase activity
VY86_RS05395	COG3022	response to hydroperoxide
VY86_RS05405	COG3335	DDE superfamily endonuclease
VY86_RS05415	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
VY86_RS05420	COG0521	Mo-molybdopterin cofactor biosynthetic process
VY86_RS05425	COG1605	Chorismate mutase
VY86_RS05445	COG0242	peptide deformylase activity
VY86_RS05450	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VY86_RS05470	COG1448	Aminotransferase
VY86_RS05490	COG1598	PFAM Uncharacterised protein family UPF0150
VY86_RS05495	COG1724	mRNA binding
VY86_RS05500	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VY86_RS05505	COG2313	pseudouridylate synthase activity
VY86_RS05515	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
VY86_RS05550	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
VY86_RS05560	COG0527	aspartate kinase activity
VY86_RS05565	COG0166	Belongs to the GPI family
VY86_RS05570	COG3161	chorismate lyase activity
VY86_RS05575	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
VY86_RS05580	COG2937	Belongs to the GPAT DAPAT family
VY86_RS05585	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
VY86_RS05590	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
VY86_RS05595	COG0735	belongs to the Fur family
VY86_RS05605	COG1304	FMN binding
VY86_RS05615	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
VY86_RS05620	COG2224	Isocitrate lyase
VY86_RS05625	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
VY86_RS05630	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
VY86_RS05660	COG0138	bifunctional purine biosynthesis protein purh
VY86_RS05665	COG0151	Belongs to the GarS family
VY86_RS05685	COG1515	deoxyribonuclease V activity
VY86_RS05690	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
VY86_RS05695	COG2816	NAD+ diphosphatase activity
VY86_RS05705	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
VY86_RS05710	COG0352	thiamine-phosphate diphosphorylase activity
VY86_RS05715	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
VY86_RS05720	COG2104	thiamine diphosphate biosynthetic process
VY86_RS05725	COG2022	thiamine diphosphate biosynthetic process
VY86_RS05745	COG2223	nitrite transmembrane transporter activity
VY86_RS05750	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VY86_RS05755	COG1063	alcohol dehydrogenase
VY86_RS05770	COG2909	trisaccharide binding
VY86_RS05775	COG0058	SHG alpha-glucan phosphorylase activity
VY86_RS05780	COG1640	4-alpha-glucanotransferase
VY86_RS05785	COG4115	mRNA cleavage
VY86_RS05790	COG2161	toxin-antitoxin pair type II binding
VY86_RS05810	COG3833	ABC-type maltose transport systems, permease component
VY86_RS05815	COG1175	transmembrane transport
VY86_RS05820	COG2182	Extracellular solute-binding protein
VY86_RS05825	COG3842	ATPase activity
VY86_RS05830	COG4580	involved in the transport of maltose and maltodextrins
VY86_RS05840	COG5433	transposase activity
VY86_RS05910	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
VY86_RS05915	COG0085	RNA polymerase activity
VY86_RS05920	COG0222	ribosome binding
VY86_RS05925	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
VY86_RS05930	COG0081	regulation of translation
VY86_RS05935	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
VY86_RS05940	COG0250	Participates in transcription elongation, termination and antitermination
VY86_RS05950	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
VY86_RS05955	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VY86_RS05960	COG0049	tRNA binding
VY86_RS05965	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
VY86_RS05970	COG2168	tRNA wobble position uridine thiolation
VY86_RS05975	COG2923	Belongs to the DsrF TusC family
VY86_RS05980	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
VY86_RS05985	COG2964	Protein conserved in bacteria
VY86_RS05990	COG0545	Peptidyl-prolyl cis-trans isomerase
VY86_RS05995	COG2900	Belongs to the SlyX family
VY86_RS06000	COG1047	Peptidyl-prolyl cis-trans
VY86_RS06005	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
VY86_RS06015	COG2249	NAD(P)H dehydrogenase (quinone) activity
VY86_RS06020	COG0488	(ABC) transporter
VY86_RS06085	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
VY86_RS06090	COG1263	PTS System
VY86_RS06090	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VY86_RS06100	COG0429	hydrolase of the alpha beta-hydrolase fold
VY86_RS06105	COG3089	Belongs to the UPF0270 family
VY86_RS06110	COG3954	Phosphoribulokinase
VY86_RS06115	COG1765	OsmC-like protein
VY86_RS06120	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VY86_RS06125	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
VY86_RS06140	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VY86_RS06145	COG0218	Necessary for normal cell division and for the maintenance of normal septation
VY86_RS06150	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VY86_RS06150	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VY86_RS06155	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VY86_RS06160	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
VY86_RS06165	COG0746	molybdenum cofactor guanylyltransferase activity
VY86_RS06170	COG1763	Mo-molybdopterin cofactor biosynthetic process
VY86_RS06180	COG0545	Peptidyl-prolyl cis-trans isomerase
VY86_RS06200	COG2192	nodulation
VY86_RS06210	COG0137	argininosuccinate synthase activity
VY86_RS06215	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
VY86_RS06220	COG0359	binds to the 23S rRNA
VY86_RS06225	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
VY86_RS06230	COG2965	DNA replication, synthesis of RNA primer
VY86_RS06235	COG0360	Binds together with S18 to 16S ribosomal RNA
VY86_RS06240	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VY86_RS06245	COG0557	exoribonuclease II activity
VY86_RS06250	COG1959	2 iron, 2 sulfur cluster binding
VY86_RS06255	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
VY86_RS06260	COG0330	HflC and HflK could
VY86_RS06265	COG0330	HflC and HflK could
VY86_RS06270	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
VY86_RS06275	COG1923	regulation of RNA biosynthetic process
VY86_RS06280	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
VY86_RS06285	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
VY86_RS06290	COG0860	N-Acetylmuramoyl-L-alanine amidase
VY86_RS06295	COG0802	atpase or kinase
VY86_RS06300	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
VY86_RS06325	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
VY86_RS06335	COG1162	GTPase activity
VY86_RS06340	COG0688	phosphatidylethanolamine metabolic process
VY86_RS06345	COG1511	domain protein
VY86_RS06345	COG3264	Mechanosensitive ion channel
VY86_RS06360	COG3501	Rhs element vgr protein
VY86_RS06420	COG0561	phosphatase activity
VY86_RS06425	COG0514	ATP-dependent DNA helicase (RecQ)
VY86_RS06430	COG2050	protein possibly involved in aromatic compounds catabolism
VY86_RS06445	COG5464	transposase or invertase
VY86_RS06450	COG0598	Magnesium transport protein CorA
VY86_RS06460	COG1011	Hydrolase
VY86_RS06470	COG3159	Protein conserved in bacteria
VY86_RS06475	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
VY86_RS06480	COG5567	small periplasmic lipoprotein
VY86_RS06485	COG1965	Belongs to the frataxin family
VY86_RS06495	COG0181	hydroxymethylbilane synthase activity
VY86_RS06500	COG1587	Uroporphyrinogen-III synthase
VY86_RS06505	COG2959	enzyme of heme biosynthesis
VY86_RS06510	COG3071	HemY protein
VY86_RS06515	COG2314	TM2 domain
VY86_RS06545	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
VY86_RS06555	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
VY86_RS06560	COG2244	polysaccharide biosynthetic process
VY86_RS06565	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
VY86_RS06570	COG0456	acetyltransferase
VY86_RS06575	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
VY86_RS06580	COG1088	dTDP-glucose 4,6-dehydratase activity
VY86_RS06585	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
VY86_RS06590	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
VY86_RS06595	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
VY86_RS06600	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
VY86_RS06605	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
VY86_RS06610	COG3118	belongs to the thioredoxin family
VY86_RS06615	COG0513	Belongs to the DEAD box helicase family
VY86_RS06620	COG0248	Ppx GppA phosphatase
VY86_RS06630	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
VY86_RS06635	COG0583	DNA-binding transcription factor activity
VY86_RS06645	COG2072	flavoprotein involved in K transport
VY86_RS06655	COG0822	iron-sulfur transferase activity
VY86_RS06660	COG1104	cysteine desulfurase activity
VY86_RS06670	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VY86_RS06685	COG1566	PFAM secretion protein HlyD family protein
VY86_RS06690	COG2814	Major facilitator Superfamily
VY86_RS06695	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
VY86_RS06700	COG0129	dihydroxy-acid dehydratase activity
VY86_RS06705	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
VY86_RS06710	COG3978	acetolactate synthase activity
VY86_RS06725	COG3085	chromosome segregation
VY86_RS06730	COG0583	DNA-binding transcription factor activity
VY86_RS06765	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
VY86_RS06775	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
VY86_RS06780	COG0009	L-threonylcarbamoyladenylate synthase
VY86_RS06785	COG0551	DNA topoisomerase type I activity
VY86_RS06790	COG0758	DNA mediated transformation
VY86_RS06795	COG0242	peptide deformylase activity
VY86_RS06800	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
VY86_RS06805	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VY86_RS06805	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
VY86_RS06810	COG0569	domain protein
VY86_RS06815	COG3036	rescue of stalled ribosome
VY86_RS06820	COG0789	Transcriptional regulator
VY86_RS06825	COG0203	ribosomal protein L17
VY86_RS06830	COG0202	RNA polymerase activity
VY86_RS06835	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
VY86_RS06845	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
VY86_RS06850	COG0201	protein transport
VY86_RS06855	COG0200	Binds to the 23S rRNA
VY86_RS06860	COG1841	ribosomal large subunit assembly
VY86_RS06865	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
VY86_RS06870	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
VY86_RS06875	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
VY86_RS06880	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
VY86_RS06885	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
VY86_RS06890	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
VY86_RS06895	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
VY86_RS06900	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
VY86_RS06905	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
VY86_RS06915	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
VY86_RS06920	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
VY86_RS06925	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
VY86_RS06930	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
VY86_RS06935	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
VY86_RS06940	COG0089	rRNA binding
VY86_RS06945	COG0088	Forms part of the polypeptide exit tunnel
VY86_RS06950	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
VY86_RS06955	COG0051	transcription antitermination factor activity, RNA binding
VY86_RS06965	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
VY86_RS06990	COG1072	(Pantothenic acid kinase))
VY86_RS07000	COG0812	UDP-N-acetylmuramate dehydrogenase activity
VY86_RS07035	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
VY86_RS07040	COG4206	TonB-dependent receptor
VY86_RS07045	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VY86_RS07060	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VY86_RS07070	COG0165	Argininosuccinate lyase
VY86_RS07075	COG0137	argininosuccinate synthase activity
VY86_RS07080	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
VY86_RS07085	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
VY86_RS07090	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VY86_RS07095	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
VY86_RS07130	COG0460	homoserine dehydrogenase
VY86_RS07130	COG0527	aspartate kinase activity
VY86_RS07135	COG0626	cystathionine gamma-synthase activity
VY86_RS07140	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
VY86_RS07145	COG0254	rRNA binding
VY86_RS07150	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
VY86_RS07155	COG1609	Transcriptional regulator
VY86_RS07160	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
VY86_RS07165	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
VY86_RS07170	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
VY86_RS07175	COG1575	Belongs to the MenA family. Type 1 subfamily
VY86_RS07180	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
VY86_RS07185	COG3074	FtsZ-dependent cytokinesis
VY86_RS07195	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
VY86_RS07205	COG3152	Membrane
VY86_RS07215	COG0149	triose-phosphate isomerase activity
VY86_RS07220	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
VY86_RS07225	COG0205	6-phosphofructokinase activity
VY86_RS07230	COG4589	Belongs to the CDS family
VY86_RS07280	COG3692	DNA binding
VY86_RS07310	COG3423	Transcriptional regulator
VY86_RS07495	COG4974	Belongs to the 'phage' integrase family
VY86_RS07500	COG3678	ATP-independent chaperone mediated protein folding
VY86_RS07505	COG0745	RESPONSE REGULATOR receiver
VY86_RS07510	COG2205	protein histidine kinase activity
VY86_RS07520	COG0673	inositol 2-dehydrogenase activity
VY86_RS07565	COG1216	Glycosyl transferase, family 2
VY86_RS07565	COG0463	Glycosyl transferase, family 2
VY86_RS07570	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
VY86_RS07575	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VY86_RS07585	COG0697	spore germination
VY86_RS07610	COG2089	acid synthase
VY86_RS07645	COG0482	sulfurtransferase activity
VY86_RS07650	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
VY86_RS07660	COG1086	Polysaccharide biosynthesis protein
VY86_RS07705	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
VY86_RS07710	COG1045	serine acetyltransferase
VY86_RS07715	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
VY86_RS07720	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
VY86_RS07725	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VY86_RS07730	COG4942	peptidase
VY86_RS07740	COG1063	alcohol dehydrogenase
VY86_RS07745	COG0156	8-amino-7-oxononanoate synthase activity
VY86_RS07750	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VY86_RS07760	COG0859	PFAM glycosyl transferase family 9
VY86_RS07780	COG0438	transferase activity, transferring glycosyl groups
VY86_RS07785	COG0438	transferase activity, transferring glycosyl groups
VY86_RS07790	COG0859	PFAM glycosyl transferase family 9
VY86_RS07795	COG1519	Transferase
VY86_RS07805	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
VY86_RS07810	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
VY86_RS07825	COG0438	transferase activity, transferring glycosyl groups
VY86_RS07835	COG0438	transferase activity, transferring glycosyl groups
VY86_RS07840	COG0267	Belongs to the bacterial ribosomal protein bL33 family
VY86_RS07845	COG0227	Belongs to the bacterial ribosomal protein bL28 family
VY86_RS07850	COG2003	Belongs to the UPF0758 family
VY86_RS07855	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
VY86_RS07860	COG0756	dUTP diphosphatase activity
VY86_RS07865	COG1309	transcriptional regulator
VY86_RS07870	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
VY86_RS07875	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
VY86_RS07880	COG1561	YicC-like family, N-terminal region
VY86_RS07885	COG3177	Filamentation induced by cAMP protein fic
VY86_RS07900	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VY86_RS07905	COG1368	sulfuric ester hydrolase activity
VY86_RS07910	COG3276	selenocysteine insertion sequence binding
VY86_RS07915	COG1921	L-seryl-tRNASec selenium transferase activity
VY86_RS07920	COG3058	Necessary for formate dehydrogenase activity
VY86_RS07930	COG2226	methyltransferase
VY86_RS07930	COG2867	negative regulation of translational initiation
VY86_RS07955	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
VY86_RS07970	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
VY86_RS07975	COG0706	membrane insertase activity
VY86_RS07980	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
VY86_RS07985	COG0594	ribonuclease P activity
VY86_RS07995	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
VY86_RS08000	COG0592	DNA-directed DNA polymerase activity
VY86_RS08005	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
VY86_RS08010	COG0187	DNA topoisomerase II activity
VY86_RS08035	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VY86_RS08050	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
VY86_RS08060	COG0257	Belongs to the bacterial ribosomal protein bL36 family
VY86_RS08065	COG0254	rRNA binding
VY86_RS08070	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
VY86_RS08075	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
VY86_RS08080	COG0355	proton-transporting ATP synthase activity, rotational mechanism
VY86_RS08085	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
VY86_RS08090	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
VY86_RS08095	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
VY86_RS08100	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
VY86_RS08105	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
VY86_RS08115	COG0356	it plays a direct role in the translocation of protons across the membrane
VY86_RS08120	COG3312	ion transport
VY86_RS08125	COG0357	Ribosomal RNA small subunit methyltransferase G
VY86_RS08130	COG0445	tRNA wobble uridine modification
VY86_RS08135	COG0716	FMN binding
VY86_RS08140	COG1522	sequence-specific DNA binding
VY86_RS08145	COG2502	aspartate--ammonia ligase
VY86_RS08150	COG2425	protein containing a von Willebrand factor type A (vWA) domain
VY86_RS08155	COG0714	Associated with various cellular activities
VY86_RS08160	COG1869	D-ribose catabolic process
VY86_RS08165	COG1129	ABC transporter
VY86_RS08170	COG1172	Belongs to the binding-protein-dependent transport system permease family
VY86_RS08180	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VY86_RS08185	COG1609	Transcriptional regulator
VY86_RS08190	COG0477	Major facilitator Superfamily
VY86_RS08195	COG2186	Transcriptional regulator
VY86_RS08220	COG2194	sulfuric ester hydrolase activity
VY86_RS08225	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VY86_RS08230	COG3162	membrane
VY86_RS08235	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VY86_RS08240	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
VY86_RS08245	COG2258	MOSC domain
VY86_RS08250	COG1595	DNA-templated transcription, initiation
VY86_RS08270	COG3220	belongs to the UPF0276 family
VY86_RS08305	COG0825	malonyl-CoA metabolic process
VY86_RS08310	COG3335	DDE superfamily endonuclease
VY86_RS08320	COG0180	Tryptophanyl-tRNA synthetase
VY86_RS08325	COG0546	phosphoglycolate phosphatase activity
VY86_RS08330	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
VY86_RS08345	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
VY86_RS08355	COG4796	Type ii and iii secretion system protein
VY86_RS08375	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
VY86_RS08380	COG0494	nUDIX hydrolase
VY86_RS08390	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
VY86_RS08395	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
VY86_RS08420	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
VY86_RS08425	COG1741	Belongs to the pirin family
VY86_RS08445	COG4566	intracellular signal transduction
VY86_RS08480	COG0583	DNA-binding transcription factor activity
VY86_RS08485	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
VY86_RS08490	COG2072	flavoprotein involved in K transport
VY86_RS08495	COG0596	Alpha beta hydrolase
VY86_RS08495	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
VY86_RS08495	COG2226	methyltransferase
VY86_RS08535	COG5433	transposase activity
VY86_RS08555	COG2081	HI0933 family
VY86_RS08560	COG0306	phosphate transporter
VY86_RS08575	COG5433	transposase activity
VY86_RS08585	COG0589	response to stress
VY86_RS08595	COG0742	ribosomal rna small subunit methyltransferase
VY86_RS08605	COG0582	viral genome integration into host DNA
VY86_RS08630	COG2378	regulation of single-species biofilm formation
VY86_RS08635	COG3596	GTP binding
VY86_RS08675	COG2003	Belongs to the UPF0758 family
VY86_RS08720	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
VY86_RS08745	COG5433	transposase activity
VY86_RS08790	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
VY86_RS08810	COG1312	Catalyzes the dehydration of D-mannonate
VY86_RS08815	COG2186	Transcriptional regulator
VY86_RS08825	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
VY86_RS08835	COG0246	Mannitol dehydrogenase
VY86_RS08840	COG1904	glucuronate isomerase
VY86_RS08845	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VY86_RS08850	COG0800	Aldolase
VY86_RS08870	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
VY86_RS08875	COG1349	DNA-binding transcription factor activity
VY86_RS08880	COG0705	Rhomboid family
VY86_RS08885	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VY86_RS08890	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
VY86_RS08890	COG0316	Belongs to the HesB IscA family
VY86_RS08895	COG1040	competence protein
VY86_RS08900	COG0596	Alpha beta hydrolase
VY86_RS08905	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
VY86_RS08940	COG1918	ferrous iron import across plasma membrane
VY86_RS08945	COG2183	response to ionizing radiation
VY86_RS08950	COG3293	Transposase
VY86_RS08960	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VY86_RS08965	COG3609	addiction module antidote protein, CC2985 family
VY86_RS09000	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
VY86_RS09005	COG0573	inorganic phosphate transmembrane transporter activity
VY86_RS09010	COG0581	inorganic phosphate transmembrane transporter activity
VY86_RS09015	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
VY86_RS09020	COG0704	Plays a role in the regulation of phosphate uptake
VY86_RS09025	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VY86_RS09030	COG0765	amino acid transport
VY86_RS09035	COG0765	amino acid transport
VY86_RS09055	COG3078	GTPase activator activity
VY86_RS09070	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
VY86_RS09110	COG1217	gtp-binding protein TYPA
VY86_RS09125	COG1966	Carbon starvation protein
VY86_RS09130	COG1011	Hydrolase
VY86_RS09135	COG1490	D-aminoacyl-tRNA deacylase activity
VY86_RS09140	COG0456	acetyltransferase
VY86_RS09150	COG3041	Addiction module toxin RelE StbE family
VY86_RS09155	COG2982	Protein involved in outer membrane biogenesis
VY86_RS09205	COG0786	glutamate:sodium symporter activity
VY86_RS09215	COG3093	addiction module antidote protein HigA
VY86_RS09230	COG3077	Addiction module antitoxin, RelB DinJ family
VY86_RS09265	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
VY86_RS09270	COG0582	viral genome integration into host DNA
VY86_RS09280	COG3121	Chaperone
VY86_RS09300	COG3121	Chaperone
VY86_RS09305	COG3121	Chaperone
VY86_RS09310	COG3188	usher protein
VY86_RS09330	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VY86_RS09335	COG1758	RNA polymerase activity
VY86_RS09340	COG0194	GDP metabolic process
VY86_RS09375	COG3620	sequence-specific DNA binding
VY86_RS09395	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
VY86_RS09400	COG2860	membrane
VY86_RS09405	COG0823	Involved in the tonB-independent uptake of proteins
VY86_RS09410	COG5645	(Lipo)protein
VY86_RS09415	COG3977	Valine--pyruvate aminotransferase
VY86_RS09420	COG2818	Glycosylase
VY86_RS09430	COG0751	glycine-tRNA ligase activity
VY86_RS09435	COG3077	Addiction module antitoxin, RelB DinJ family
VY86_RS09440	COG3041	Addiction module toxin RelE StbE family
VY86_RS09450	COG2226	methyltransferase
VY86_RS09455	COG1695	Transcriptional regulator
VY86_RS09460	COG2124	cytochrome p450
VY86_RS09510	COG0747	negative chemotaxis
VY86_RS09515	COG0601	transmembrane transport
VY86_RS09520	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VY86_RS09525	COG0444	Belongs to the ABC transporter superfamily
VY86_RS09530	COG4608	Belongs to the ABC transporter superfamily
VY86_RS09535	COG2199	diguanylate cyclase activity
VY86_RS09535	COG2200	EAL domain
VY86_RS09540	COG0612	Peptidase, M16
VY86_RS09545	COG1942	4-Oxalocrotonate Tautomerase
VY86_RS09550	COG1295	ribonuclease BN
VY86_RS09640	COG2197	response regulator
VY86_RS09645	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
VY86_RS09650	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VY86_RS09655	COG4104	PAAR repeat-containing protein
VY86_RS09655	COG3209	COG3209 Rhs family protein
VY86_RS09665	COG4104	PAAR repeat-containing protein
VY86_RS09665	COG3209	COG3209 Rhs family protein
VY86_RS09705	COG3209	COG3209 Rhs family protein
VY86_RS09705	COG4104	PAAR repeat-containing protein
VY86_RS09720	COG4974	Belongs to the 'phage' integrase family
VY86_RS09725	COG0358	DNA primase activity
VY86_RS09730	COG2932	Transcriptional regulator
VY86_RS09765	COG4974	Belongs to the 'phage' integrase family
VY86_RS09770	COG0358	DNA primase activity
VY86_RS09775	COG2932	Transcriptional regulator
VY86_RS09810	COG4974	Belongs to the 'phage' integrase family
VY86_RS09815	COG0358	DNA primase activity
VY86_RS09820	COG1476	TRANSCRIPTIONal
VY86_RS09840	COG3209	COG3209 Rhs family protein
VY86_RS09840	COG4104	PAAR repeat-containing protein
VY86_RS09860	COG3501	Rhs element vgr protein
VY86_RS09880	COG3727	T/G mismatch-specific endonuclease activity
VY86_RS09920	COG4974	Belongs to the 'phage' integrase family
VY86_RS09930	COG0358	DNA primase activity
VY86_RS09935	COG3620	sequence-specific DNA binding
VY86_RS09970	COG4974	Belongs to the 'phage' integrase family
VY86_RS09975	COG0358	DNA primase activity
VY86_RS09980	COG1476	TRANSCRIPTIONal
VY86_RS10015	COG4974	Belongs to the 'phage' integrase family
VY86_RS10020	COG0358	DNA primase activity
VY86_RS10025	COG1476	TRANSCRIPTIONal
VY86_RS10055	COG3501	Rhs element vgr protein
VY86_RS10145	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
VY86_RS10150	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VY86_RS10160	COG4772	TonB-dependent receptor
VY86_RS10165	COG3712	iron ion homeostasis
VY86_RS10170	COG1595	DNA-templated transcription, initiation
VY86_RS10175	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
VY86_RS10185	COG1253	flavin adenine dinucleotide binding
VY86_RS10190	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VY86_RS10195	COG0729	surface antigen
VY86_RS10200	COG2911	Protein conserved in bacteria
VY86_RS10205	COG2105	PFAM AIG2 family protein
VY86_RS10240	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
VY86_RS10245	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VY86_RS10250	COG1438	arginine binding
VY86_RS10255	COG0039	L-malate dehydrogenase activity
VY86_RS10260	COG3423	Transcriptional regulator
VY86_RS10275	COG0142	geranyltranstransferase activity
VY86_RS10280	COG0261	This protein binds to 23S rRNA in the presence of protein L20
VY86_RS10285	COG0211	Belongs to the bacterial ribosomal protein bL27 family
VY86_RS10290	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
VY86_RS10295	COG2027	D-alanyl-D-alanine carboxypeptidase
VY86_RS10305	COG1534	Rna-binding protein
VY86_RS10310	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
VY86_RS10320	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
VY86_RS10325	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VY86_RS10330	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VY86_RS10345	COG0779	Required for maturation of 30S ribosomal subunits
VY86_RS10350	COG0195	Participates in both transcription termination and antitermination
VY86_RS10355	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
VY86_RS10360	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
VY86_RS10365	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
VY86_RS10385	COG0513	Belongs to the DEAD box helicase family
VY86_RS10405	COG0675	Transposase, IS605 OrfB family
VY86_RS10480	COG0318	PFAM AMP-dependent synthetase and ligase
VY86_RS10490	COG0574	Belongs to the PEP-utilizing enzyme family
VY86_RS10490	COG3848	Pyruvate phosphate dikinase
VY86_RS10515	COG3153	acetyltransferase
VY86_RS10520	COG2827	Endonuclease containing a URI domain
VY86_RS10530	COG3787	Belongs to the UPF0306 family
VY86_RS10535	COG0602	queuosine metabolic process
VY86_RS10550	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
VY86_RS10565	COG0540	Belongs to the ATCase OTCase family
VY86_RS10570	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
VY86_RS10575	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
VY86_RS10595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VY86_RS10600	COG1126	abc transporter atp-binding protein
VY86_RS10605	COG0765	amino acid transport
VY86_RS10610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VY86_RS10620	COG0525	valine-tRNA ligase activity
VY86_RS10625	COG2927	DNA polymerase III (CHI subunit)
VY86_RS10630	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
VY86_RS10635	COG0795	lipopolysaccharide-transporting ATPase activity
VY86_RS10640	COG0795	lipopolysaccharide-transporting ATPase activity
VY86_RS10645	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
VY86_RS10655	COG0582	viral genome integration into host DNA
VY86_RS10660	COG3423	Transcriptional regulator
VY86_RS10700	COG0464	growth
VY86_RS10730	COG3293	Transposase
VY86_RS10745	COG3586	endonuclease activity
VY86_RS10755	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
VY86_RS10770	COG3541	Predicted nucleotidyltransferase
VY86_RS10775	COG1690	Belongs to the RtcB family
VY86_RS10790	COG4770	biotin carboxylase activity
VY86_RS10795	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
VY86_RS10800	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
VY86_RS10815	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
VY86_RS10840	COG2194	sulfuric ester hydrolase activity
VY86_RS10855	COG0675	Transposase, IS605 OrfB family
VY86_RS10870	COG2252	PERMEase
VY86_RS10875	COG0025	NhaP-type Na H and K H
VY86_RS10880	COG0583	DNA-binding transcription factor activity
VY86_RS10885	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
VY86_RS10895	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
VY86_RS10910	COG0586	Pfam SNARE associated Golgi protein
VY86_RS10915	COG1322	Protein conserved in bacteria
VY86_RS10920	COG2226	methyltransferase
VY86_RS10925	COG3165	ubiquinone biosynthetic process from chorismate
VY86_RS10930	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
VY86_RS10935	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VY86_RS10940	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VY86_RS10945	COG0805	protein transport
VY86_RS10965	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
VY86_RS10975	COG0183	Belongs to the thiolase family
VY86_RS10980	COG1250	3-hydroxyacyl-CoA dehydrogenase
VY86_RS10980	COG1024	Enoyl-CoA hydratase
VY86_RS10985	COG0006	proline dipeptidase activity
VY86_RS10990	COG1739	Uncharacterized protein family UPF0029
VY86_RS10995	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VY86_RS11035	COG4372	Transposase
VY86_RS11045	COG1609	Transcriptional regulator
VY86_RS11050	COG3265	gluconokinase activity
VY86_RS11055	COG2610	gluconate transmembrane transporter activity
VY86_RS11085	COG1696	Membrane protein involved in D-alanine export
VY86_RS11090	COG2992	FlgJ-related protein
VY86_RS11100	COG3188	usher protein
VY86_RS11130	COG3135	benzoate transporter
VY86_RS11135	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
VY86_RS11150	COG3344	reverse transcriptase
VY86_RS11205	COG2814	Major facilitator Superfamily
VY86_RS11225	COG5642	Protein of unknown function (DUF2384)
VY86_RS11230	COG5654	RES domain protein
VY86_RS11245	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
VY86_RS11255	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VY86_RS11265	COG0318	PFAM AMP-dependent synthetase and ligase
VY86_RS11290	COG5433	transposase activity
VY86_RS11390	COG0596	Alpha beta hydrolase
VY86_RS11395	COG1301	dicarboxylic acid transport
VY86_RS11410	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
VY86_RS11415	COG0033	Phosphoglucomutase
VY86_RS11445	COG3335	DDE superfamily endonuclease
VY86_RS11450	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
VY86_RS11455	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VY86_RS11455	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
VY86_RS11460	COG0561	phosphatase activity
VY86_RS11465	COG0745	RESPONSE REGULATOR receiver
VY86_RS11470	COG2205	protein histidine kinase activity
VY86_RS11475	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
VY86_RS11480	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
VY86_RS11485	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
VY86_RS11555	COG5433	transposase activity
VY86_RS11595	COG1484	DNA-dependent DNA replication
VY86_RS11655	COG3772	lysozyme
VY86_RS11700	COG4974	Belongs to the 'phage' integrase family
VY86_RS11705	COG0358	DNA primase activity
VY86_RS11710	COG2932	Transcriptional regulator
VY86_RS11750	COG3604	Transcriptional regulator
VY86_RS11775	COG2144	transferase activity, transferring acyl groups
VY86_RS11785	COG2072	flavoprotein involved in K transport
VY86_RS11790	COG2226	methyltransferase
VY86_RS11840	COG3328	transposase activity
VY86_RS11845	COG1262	PFAM Formylglycine-generating sulfatase enzyme
VY86_RS11895	COG2991	Protein conserved in bacteria
VY86_RS11900	COG1477	protein flavinylation
VY86_RS11905	COG2871	sodium ion transport
VY86_RS11910	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VY86_RS11915	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VY86_RS11920	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VY86_RS11925	COG1805	sodium ion transport
VY86_RS11930	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VY86_RS11935	COG3034	peptidoglycan biosynthetic process
VY86_RS11940	COG0121	glutamine amidotransferase
VY86_RS11945	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VY86_RS11950	COG1960	acyl-CoA dehydrogenase activity
VY86_RS11960	COG0583	DNA-binding transcription factor activity
VY86_RS11965	COG0583	DNA-binding transcription factor activity
VY86_RS12000	COG1385	rRNA (uridine-N3-)-methyltransferase activity
VY86_RS12005	COG0189	ligase activity
VY86_RS12010	COG1678	Uncharacterized ACR, COG1678
VY86_RS12015	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
VY86_RS12020	COG2805	Type II/IV secretion system protein
VY86_RS12025	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
VY86_RS12030	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
VY86_RS12035	COG0762	integral membrane protein
VY86_RS12040	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
VY86_RS12045	COG0635	Involved in the biosynthesis of porphyrin-containing compound
VY86_RS12055	COG4974	Belongs to the 'phage' integrase family
VY86_RS12115	COG4695	Portal protein
VY86_RS12210	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
VY86_RS12230	COG3423	Transcriptional regulator
VY86_RS12245	COG2066	Belongs to the glutaminase family
VY86_RS12250	COG3171	Protein conserved in bacteria
VY86_RS12255	COG0220	tRNA (guanine-N7-)-methyltransferase activity
VY86_RS12265	COG1194	a g-specific adenine glycosylase
VY86_RS12270	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
VY86_RS12275	COG0741	lytic transglycosylase activity
VY86_RS12330	COG5433	transposase activity
VY86_RS12385	COG3657	addiction module killer protein
VY86_RS12430	COG2030	dehydratase
VY86_RS12450	COG5433	transposase activity
VY86_RS12475	COG3121	Chaperone
VY86_RS12480	COG3188	usher protein
VY86_RS12495	COG2977	Belongs to the P-Pant transferase superfamily
VY86_RS12500	COG1846	Transcriptional regulator
VY86_RS12515	COG1012	belongs to the aldehyde dehydrogenase family
VY86_RS12520	COG3384	dioxygenase
VY86_RS12530	COG2814	Major facilitator Superfamily
VY86_RS12540	COG3971	2-oxopent-4-enoate hydratase activity
VY86_RS12600	COG2974	May be involved in recombination
VY86_RS12610	COG0675	Transposase, IS605 OrfB family
VY86_RS12620	COG0737	Belongs to the 5'-nucleotidase family
VY86_RS12625	COG3719	Belongs to the RNase T2 family
VY86_RS12640	COG0167	dihydroorotate dehydrogenase activity
VY86_RS12790	COG1309	transcriptional regulator
VY86_RS12795	COG4232	protein-disulfide reductase activity
VY86_RS12800	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
VY86_RS12815	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
VY86_RS12820	COG0459	protein refolding
VY86_RS12825	COG0583	DNA-binding transcription factor activity
VY86_RS12840	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
VY86_RS12845	COG2076	Multidrug Resistance protein
VY86_RS12850	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
VY86_RS12855	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
VY86_RS12860	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
VY86_RS12865	COG1053	succinate dehydrogenase
VY86_RS12875	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
VY86_RS12880	COG0584	glycerophosphoryl diester phosphodiesterase
VY86_RS12885	COG2271	Major facilitator Superfamily
VY86_RS12900	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
VY86_RS12905	COG0425	Belongs to the sulfur carrier protein TusA family
VY86_RS12930	COG3776	membrane
VY86_RS12935	COG0742	ribosomal rna small subunit methyltransferase
VY86_RS12940	COG0552	protein localization to endoplasmic reticulum
VY86_RS12940	COG0552	protein localization to endoplasmic reticulum
VY86_RS12945	COG2884	Cell division ATP-binding protein ftsE
VY86_RS12950	COG2177	Part of the ABC transporter FtsEX involved in
VY86_RS12955	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
VY86_RS12960	COG1929	Belongs to the glycerate kinase type-1 family
VY86_RS12970	COG0683	leucine binding
VY86_RS12975	COG0559	Belongs to the binding-protein-dependent transport system permease family
VY86_RS13005	COG2814	Major facilitator Superfamily
VY86_RS13020	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
VY86_RS13025	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VY86_RS13030	COG2264	protein methyltransferase activity
VY86_RS13035	COG4145	pantothenate transmembrane transporter activity
VY86_RS13040	COG3924	membrane
VY86_RS13060	COG2831	hemolysin activation secretion protein
VY86_RS13090	COG4974	Belongs to the 'phage' integrase family
VY86_RS13130	COG4974	Belongs to the 'phage' integrase family
VY86_RS13145	COG0439	Biotin carboxylase
VY86_RS13150	COG0511	ligase activity, forming carbon-carbon bonds
VY86_RS13155	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
VY86_RS13160	COG0604	alcohol dehydrogenase
VY86_RS13165	COG1077	Cell shape determining protein MreB Mrl
VY86_RS13170	COG1792	Involved in formation and maintenance of cell shape
VY86_RS13175	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
VY86_RS13180	COG0424	maF-like protein
VY86_RS13185	COG1530	ribonuclease E activity
VY86_RS13190	COG3164	Protein of unknown function
VY86_RS13195	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VY86_RS13200	COG0312	modulator of DNA gyrase
VY86_RS13205	COG3028	Belongs to the UPF0307 family
VY86_RS13210	COG0312	modulator of DNA gyrase
VY86_RS13215	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VY86_RS13220	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VY86_RS13225	COG1660	Displays ATPase and GTPase activities
VY86_RS13235	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VY86_RS13240	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
VY86_RS13245	COG1137	ATPase activity
VY86_RS13250	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
VY86_RS13255	COG3117	lipopolysaccharide transmembrane transporter activity
VY86_RS13260	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
VY86_RS13265	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
VY86_RS13265	COG0517	IMP dehydrogenase activity
VY86_RS13270	COG0530	calcium, potassium:sodium antiporter activity
VY86_RS13275	COG1127	ABC transporter
VY86_RS13280	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
VY86_RS13285	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
VY86_RS13290	COG2854	intermembrane phospholipid transfer
VY86_RS13300	COG5007	Belongs to the BolA IbaG family
VY86_RS13305	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
VY86_RS13310	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VY86_RS13315	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VY86_RS13320	COG3105	Protein conserved in bacteria
VY86_RS13330	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
VY86_RS13335	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
VY86_RS13340	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
VY86_RS13345	COG0625	glutathione transferase activity
VY86_RS13350	COG2969	positive regulation of protein catabolic process
VY86_RS13360	COG0493	'glutamate synthase
VY86_RS13365	COG0070	glutamate synthase
VY86_RS13365	COG0069	glutamate synthase activity
VY86_RS13365	COG0067	glutamate synthase
VY86_RS13370	COG0784	Response regulator, receiver
VY86_RS13370	COG5002	protein histidine kinase activity
VY86_RS13370	COG2198	Histidine kinase
VY86_RS13375	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
VY86_RS13380	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
VY86_RS13385	COG2823	Periplasmic or secreted lipoprotein
VY86_RS13390	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VY86_RS13395	COG0792	nuclease activity
VY86_RS13405	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
VY86_RS13410	COG1741	Belongs to the pirin family
VY86_RS13415	COG0583	DNA-binding transcription factor activity
VY86_RS13420	COG2259	Doxx family
VY86_RS13430	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
VY86_RS13435	COG4575	ribosome binding
VY86_RS13440	COG0586	Pfam SNARE associated Golgi protein
VY86_RS13445	COG0861	Integral membrane protein TerC family
VY86_RS13450	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
VY86_RS13455	COG0446	pyridine nucleotide-disulphide oxidoreductase
VY86_RS13455	COG1902	pentaerythritol trinitrate reductase activity
VY86_RS13465	COG2990	Protein conserved in bacteria
VY86_RS13470	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
VY86_RS13475	COG4106	trans-aconitate 2-methyltransferase activity
VY86_RS13515	COG0358	DNA primase activity
VY86_RS13520	COG0828	Belongs to the bacterial ribosomal protein bS21 family
VY86_RS13525	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
VY86_RS13530	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
VY86_RS13535	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
VY86_RS13540	COG1968	undecaprenyl-diphosphatase activity
VY86_RS13545	COG0617	tRNA 3'-terminal CCA addition
VY86_RS13550	COG4991	sh3 domain protein
VY86_RS13555	COG3025	triphosphatase activity
VY86_RS13560	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
VY86_RS13565	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
VY86_RS13565	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
VY86_RS13600	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
VY86_RS13605	COG3384	dioxygenase
VY86_RS13650	COG0754	glutathionylspermidine amidase activity
VY86_RS13655	COG5463	Belongs to the UPF0441 family
VY86_RS13675	COG2814	Major facilitator Superfamily
VY86_RS13680	COG1538	Outer membrane efflux protein
VY86_RS13685	COG0494	nUDIX hydrolase
VY86_RS13690	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
VY86_RS13695	COG3150	esterase
VY86_RS13715	COG2132	Multicopper oxidase
VY86_RS13720	COG0656	L-ascorbic acid biosynthetic process
VY86_RS13745	COG0626	cystathionine gamma-synthase activity
VY86_RS13755	COG0848	biopolymer transport protein
VY86_RS13780	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
VY86_RS13780	COG2070	2-Nitropropane dioxygenase
VY86_RS13785	COG0604	alcohol dehydrogenase
VY86_RS13785	COG3321	synthase
VY86_RS13790	COG3321	synthase
VY86_RS13790	COG0604	alcohol dehydrogenase
VY86_RS13790	COG3321	synthase
VY86_RS13790	COG0604	alcohol dehydrogenase
VY86_RS13810	COG2368	4-hydroxyphenylacetate
VY86_RS13815	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
VY86_RS13820	COG3104	oligopeptide transport
VY86_RS13830	COG2226	methyltransferase
VY86_RS13885	COG3657	addiction module killer protein
VY86_RS13890	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
VY86_RS13895	COG5433	transposase activity
VY86_RS14040	COG0519	Catalyzes the synthesis of GMP from XMP
VY86_RS14065	COG0534	Mate efflux family protein
VY86_RS14075	COG2873	o-acetylhomoserine
VY86_RS14125	COG0372	Belongs to the citrate synthase family
VY86_RS14165	COG0675	Transposase, IS605 OrfB family
VY86_RS14175	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
VY86_RS14185	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
VY86_RS14190	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VY86_RS14195	COG4974	Belongs to the 'phage' integrase family
VY86_RS14200	COG0716	FMN binding
VY86_RS14210	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
VY86_RS14215	COG0354	folic acid binding
VY86_RS14265	COG0477	Major facilitator Superfamily
VY86_RS14275	COG0512	Glutamine amidotransferase of anthranilate synthase
VY86_RS14275	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VY86_RS14285	COG0156	8-amino-7-oxononanoate synthase activity
VY86_RS14290	COG2890	protein-(glutamine-N5) methyltransferase activity
VY86_RS14315	COG0588	phosphoglycerate mutase activity
VY86_RS14325	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VY86_RS14335	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
VY86_RS14360	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
VY86_RS14365	COG2885	chlorophyll binding
VY86_RS14370	COG0823	Involved in the tonB-independent uptake of proteins
VY86_RS14375	COG3064	Membrane
VY86_RS14380	COG0848	biopolymer transport protein
VY86_RS14385	COG0811	peptide transport
VY86_RS14390	COG0824	Thioesterase
VY86_RS14405	COG1294	oxidase, subunit
VY86_RS14410	COG1271	oxidase subunit
VY86_RS14415	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
VY86_RS14420	COG0045	succinate-CoA ligase (ADP-forming) activity
VY86_RS14425	COG0508	dehydrogenase complex catalyzes the overall conversion of
VY86_RS14430	COG0567	Dehydrogenase, E1 component
VY86_RS14435	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
VY86_RS14440	COG1053	succinate dehydrogenase
VY86_RS14445	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
VY86_RS14455	COG0372	Belongs to the citrate synthase family
VY86_RS14460	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
VY86_RS14490	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
VY86_RS14490	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
VY86_RS14495	COG0509	glycine decarboxylation via glycine cleavage system
VY86_RS14500	COG0404	The glycine cleavage system catalyzes the degradation of glycine
VY86_RS14505	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VY86_RS14510	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VY86_RS14515	COG0006	proline dipeptidase activity
VY86_RS14520	COG3079	Belongs to the UPF0149 family
VY86_RS14525	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
VY86_RS14530	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
VY86_RS14535	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VY86_RS14540	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
VY86_RS14545	COG0583	DNA-binding transcription factor activity
VY86_RS14555	COG1279	arginine transmembrane transporter activity
VY86_RS14565	COG3335	DDE superfamily endonuclease
VY86_RS14575	COG3112	Uncharacterised protein family (UPF0231)
VY86_RS14615	COG0347	Belongs to the P(II) protein family
VY86_RS14620	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
VY86_RS14620	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VY86_RS14625	COG2204	response regulator
VY86_RS14630	COG3170	Tfp pilus assembly protein FimV
VY86_RS14635	COG2205	protein histidine kinase activity
VY86_RS14660	COG3385	transposase activity
VY86_RS14685	COG1720	tRNA m6t6A37 methyltransferase activity
VY86_RS14720	COG0047	phosphoribosylformylglycinamidine synthase activity
VY86_RS14720	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
VY86_RS14725	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
VY86_RS14735	COG5301	cellulose 1,4-beta-cellobiosidase activity
VY86_RS14765	COG2239	Acts as a magnesium transporter
VY86_RS14770	COG3091	SprT-like family
VY86_RS14775	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
VY86_RS14780	COG1166	arginine decarboxylase activity
VY86_RS14785	COG0010	Belongs to the arginase family
VY86_RS14790	COG0861	Integral membrane protein TerC family
VY86_RS14795	COG3066	DNA modification
VY86_RS14800	COG4533	DNA binding
VY86_RS14805	COG0066	3-isopropylmalate dehydratase activity
VY86_RS14810	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
VY86_RS14815	COG0473	3-isopropylmalate dehydrogenase activity
VY86_RS14820	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
VY86_RS14830	COG1022	Amp-dependent synthetase and ligase
VY86_RS14860	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
VY86_RS14870	COG0028	Belongs to the TPP enzyme family
VY86_RS14885	COG2001	Belongs to the MraZ family
VY86_RS14890	COG0275	rRNA processing
VY86_RS14895	COG3116	cell division
VY86_RS14900	COG0768	penicillin binding
VY86_RS14905	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
VY86_RS14910	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
VY86_RS14915	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
VY86_RS14920	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
VY86_RS14925	COG0772	Belongs to the SEDS family
VY86_RS14930	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
VY86_RS14935	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VY86_RS14940	COG1181	Belongs to the D-alanine--D-alanine ligase family
VY86_RS14945	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
VY86_RS14950	COG0849	cell division
VY86_RS14955	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
VY86_RS14960	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
VY86_RS14975	COG0653	protein targeting
VY86_RS14980	COG0494	nUDIX hydrolase
VY86_RS14985	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
VY86_RS14990	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
VY86_RS14995	COG0237	dephospho-CoA kinase activity
VY86_RS15005	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VY86_RS15010	COG4969	Belongs to the N-Me-Phe pilin family
VY86_RS15020	COG3725	Membrane protein required for beta-lactamase induction
VY86_RS15030	COG3655	Transcriptional regulator
VY86_RS15045	COG2186	Transcriptional regulator
VY86_RS15050	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
VY86_RS15055	COG0508	dehydrogenase complex catalyzes the overall conversion of
VY86_RS15060	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VY86_RS15115	COG1119	ATPase activity
VY86_RS15120	COG2005	Transcriptional regulator
VY86_RS15120	COG3585	molybdate ion transport
VY86_RS15130	COG0725	ABC transporter, periplasmic molybdate-binding protein
VY86_RS15135	COG4149	molybdate abc transporter
VY86_RS15140	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
VY86_RS15145	COG0561	phosphatase activity
VY86_RS15150	COG2706	6-phosphogluconolactonase activity
VY86_RS15165	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
VY86_RS15170	COG0156	8-amino-7-oxononanoate synthase activity
VY86_RS15175	COG2226	methyltransferase
VY86_RS15180	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
VY86_RS15200	COG0556	nucleotide-excision repair
VY86_RS15205	COG0391	Required for morphogenesis under gluconeogenic growth conditions
VY86_RS15210	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
VY86_RS15215	COG0315	cyclic pyranopterin monophosphate synthase activity
VY86_RS15220	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
VY86_RS15225	COG0314	molybdopterin synthase activity
VY86_RS15230	COG0670	Belongs to the BI1 family
VY86_RS15235	COG0842	Transport permease protein
VY86_RS15240	COG0842	Transport permease protein
VY86_RS15245	COG1131	(ABC) transporter
VY86_RS15255	COG1309	transcriptional regulator
VY86_RS15265	COG0513	Belongs to the DEAD box helicase family
VY86_RS15270	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VY86_RS15290	COG2897	thiosulfate sulfurtransferase activity
VY86_RS15300	COG1199	ATP-dependent helicase activity
VY86_RS15305	COG2824	Alkylphosphonate utilization operon protein PhnA
VY86_RS15315	COG5006	permease, DMT superfamily
VY86_RS15330	COG1309	transcriptional regulator
VY86_RS15335	COG2130	NADP-dependent
VY86_RS15340	COG1979	alcohol dehydrogenase
VY86_RS15345	COG0488	(ABC) transporter
VY86_RS15350	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
VY86_RS15355	COG0303	'Molybdopterin
VY86_RS15365	COG1028	Short-chain dehydrogenase reductase Sdr
VY86_RS15375	COG0477	Major facilitator Superfamily
VY86_RS15380	COG0302	gtp cyclohydrolase
VY86_RS15385	COG2311	Membrane
VY86_RS15390	COG2949	membrane
VY86_RS15400	COG0281	malic enzyme
VY86_RS15405	COG0295	cytidine deaminase activity
VY86_RS15410	COG1346	cytolysis
VY86_RS15415	COG1380	Effector of murein hydrolase LrgA
VY86_RS15420	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VY86_RS15420	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VY86_RS15425	COG0489	protein tyrosine kinase activity
VY86_RS15430	COG0572	uridine kinase
VY86_RS15435	COG0717	Belongs to the dCTP deaminase family
VY86_RS15440	COG2982	Protein involved in outer membrane biogenesis
VY86_RS15445	COG1253	flavin adenine dinucleotide binding
VY86_RS15470	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
VY86_RS15475	COG1454	alcohol dehydrogenase
VY86_RS15485	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
VY86_RS15485	COG0140	phosphoribosyl-ATP diphosphatase activity
VY86_RS15490	COG0107	imidazoleglycerol-phosphate synthase activity
VY86_RS15495	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
VY86_RS15500	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
VY86_RS15505	COG0131	Imidazoleglycerol-phosphate dehydratase
VY86_RS15505	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VY86_RS15510	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
VY86_RS15510	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
VY86_RS15515	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
VY86_RS15515	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
VY86_RS15520	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
VY86_RS15525	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VY86_RS15530	COG0625	glutathione transferase activity
VY86_RS15535	COG1686	Belongs to the peptidase S11 family
VY86_RS15560	COG0814	amino acid
VY86_RS15565	COG0671	phosphoesterase, PA-phosphatase related
VY86_RS15585	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VY86_RS15590	COG4160	amino acid transport
VY86_RS15595	COG4215	(ABC) transporter
VY86_RS15600	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VY86_RS15605	COG1126	abc transporter atp-binding protein
VY86_RS15610	COG2431	L-lysine efflux transmembrane transporter activity
VY86_RS15615	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VY86_RS15620	COG0577	efflux transmembrane transporter activity
VY86_RS15620	COG1136	(ABC) transporter
VY86_RS15625	COG1278	Cold shock
VY86_RS15630	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
VY86_RS15635	COG0542	response to heat
VY86_RS15640	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
VY86_RS15645	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
VY86_RS15650	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
VY86_RS15660	COG0492	ferredoxin-NADP+ reductase activity
VY86_RS15670	COG1674	ftsk spoiiie
VY86_RS15670	COG3107	peptidoglycan biosynthetic process
VY86_RS15675	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
VY86_RS15680	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
VY86_RS15685	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
VY86_RS15690	COG0705	Rhomboid family
VY86_RS15710	COG5433	transposase activity
VY86_RS15725	COG3335	DDE superfamily endonuclease
VY86_RS15740	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
VY86_RS15745	COG1882	Formate acetyltransferase
VY86_RS15750	COG2116	formate transmembrane transporter activity
VY86_RS15755	COG1944	ATP diphosphatase activity
VY86_RS15760	COG0252	asparaginase activity
VY86_RS15765	COG4453	Protein conserved in bacteria
VY86_RS15775	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
VY86_RS15780	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
VY86_RS15785	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
VY86_RS15790	COG0539	negative regulation of cytoplasmic translation
VY86_RS15795	COG0776	regulation of translation
VY86_RS15820	COG2333	competence protein COMEC
VY86_RS15820	COG0658	competence protein
VY86_RS15825	COG1132	(ABC) transporter
VY86_RS15830	COG1663	tetraacyldisaccharide 4'-kinase activity
VY86_RS15840	COG2835	tetraacyldisaccharide 4'-kinase activity
VY86_RS15845	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
VY86_RS15850	COG1434	Gram-negative-bacterium-type cell wall biogenesis
VY86_RS15855	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VY86_RS15860	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
VY86_RS15865	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
VY86_RS15870	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
VY86_RS15875	COG2161	toxin-antitoxin pair type II binding
VY86_RS15930	COG1222	aaa ATPase
VY86_RS16010	COG5539	protein K27-linked deubiquitination
VY86_RS16010	COG3774	pathogenesis
VY86_RS16020	COG1222	aaa ATPase
VY86_RS16095	COG5464	transposase or invertase
VY86_RS16100	COG5464	transposase or invertase
VY86_RS16155	COG4962	Type ii secretion system protein e
VY86_RS16175	COG0857	belongs to the CobB CobQ family
VY86_RS16175	COG0280	phosphate acetyltransferase
VY86_RS16180	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
VY86_RS16190	COG0471	metal ion transport
VY86_RS16190	COG0490	domain, Protein
VY86_RS16200	COG0436	Aminotransferase
VY86_RS16205	COG0583	DNA-binding transcription factor activity
VY86_RS16210	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
VY86_RS16215	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
VY86_RS16220	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
VY86_RS16220	COG0649	NAD binding
VY86_RS16230	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
VY86_RS16235	COG1034	ATP synthesis coupled electron transport
VY86_RS16240	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
VY86_RS16245	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
VY86_RS16250	COG0839	Belongs to the complex I subunit 6 family
VY86_RS16255	COG0713	ATP synthesis coupled electron transport
VY86_RS16260	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
VY86_RS16265	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
VY86_RS16270	COG1007	ATP synthesis coupled electron transport
VY86_RS16295	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
VY86_RS16300	COG0596	Alpha beta hydrolase
VY86_RS16305	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
VY86_RS16310	COG1441	menaquinone biosynthetic process
VY86_RS16315	COG0318	PFAM AMP-dependent synthetase and ligase
VY86_RS16330	COG0814	amino acid
VY86_RS16385	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
VY86_RS16395	COG0673	inositol 2-dehydrogenase activity
VY86_RS16410	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VY86_RS16420	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VY86_RS16425	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VY86_RS16435	COG2205	protein histidine kinase activity
VY86_RS16435	COG0784	Response regulator, receiver
VY86_RS16445	COG2198	Histidine kinase
VY86_RS16445	COG0642	Histidine kinase
VY86_RS16475	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
VY86_RS16580	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
VY86_RS16610	COG2944	sequence-specific DNA binding
VY86_RS16615	COG2194	sulfuric ester hydrolase activity
VY86_RS16640	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
VY86_RS16655	COG0438	transferase activity, transferring glycosyl groups
VY86_RS16660	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
VY86_RS16670	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
VY86_RS16675	COG3657	addiction module killer protein
VY86_RS16685	COG3381	protein complex oligomerization
VY86_RS16695	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
VY86_RS16705	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
VY86_RS16770	COG1492	cobalamin metabolic process
VY86_RS16780	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
VY86_RS16790	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
VY86_RS16795	COG1598	PFAM Uncharacterised protein family UPF0150
VY86_RS16830	COG4302	ethanolamine ammonia-lyase activity
VY86_RS16835	COG4303	Ethanolamine ammonia lyase large subunit
VY86_RS16845	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
VY86_RS16845	COG1648	precorrin-2 dehydrogenase activity
VY86_RS16850	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
VY86_RS16865	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
VY86_RS16915	COG3083	sulfuric ester hydrolase activity
VY86_RS16920	COG3082	Protein of unknown function (DUF1414)
VY86_RS16925	COG3081	Nucleoid-associated protein
VY86_RS16930	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
VY86_RS16935	COG1061	Type III restriction enzyme res subunit
VY86_RS16940	COG1187	pseudouridine synthase activity
VY86_RS16945	COG2814	Major facilitator Superfamily
VY86_RS16955	COG0791	NLP P60 protein
VY86_RS16970	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
VY86_RS16980	COG0494	nUDIX hydrolase
VY86_RS16985	COG1105	Belongs to the carbohydrate kinase PfkB family
VY86_RS16990	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
VY86_RS16995	COG2855	membrane
VY86_RS17000	COG0583	DNA-binding transcription factor activity
VY86_RS17005	COG0833	amino acid
VY86_RS17015	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VY86_RS17020	COG3842	ATPase activity
VY86_RS17025	COG4771	TonB-dependent receptor
VY86_RS17030	COG0531	amino acid
VY86_RS17035	COG0277	FAD linked oxidase domain protein
VY86_RS17040	COG2925	Exonuclease
VY86_RS17045	COG3157	Type VI secretion system effector, Hcp
VY86_RS17095	COG2926	Belongs to the UPF0265 family
VY86_RS17100	COG0702	epimerase
VY86_RS17105	COG1530	ribonuclease E activity
VY86_RS17110	COG0564	pseudouridine synthase activity
VY86_RS17115	COG0424	maF-like protein
VY86_RS17120	COG1399	metal-binding, possibly nucleic acid-binding protein
VY86_RS17125	COG0333	Belongs to the bacterial ribosomal protein bL32 family
VY86_RS17130	COG0416	fatty acid biosynthetic process
VY86_RS17135	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VY86_RS17140	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
VY86_RS17145	COG1028	Short-chain dehydrogenase reductase Sdr
VY86_RS17150	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VY86_RS17155	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VY86_RS17160	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
VY86_RS17165	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
VY86_RS17170	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
VY86_RS17175	COG0470	DNA polymerase III
VY86_RS17180	COG0084	hydrolase, TatD family'
VY86_RS17185	COG0537	adenosine 5'-monophosphoramidase activity
VY86_RS17190	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
VY86_RS17200	COG1472	Belongs to the glycosyl hydrolase 3 family
VY86_RS17205	COG1252	NADH dehydrogenase
VY86_RS17230	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
VY86_RS17235	COG4591	ABC-type transport system involved in lipoprotein release permease component
VY86_RS17240	COG1136	(ABC) transporter
VY86_RS17245	COG4591	ABC-type transport system involved in lipoprotein release permease component
VY86_RS17255	COG0675	Transposase, IS605 OrfB family
VY86_RS17260	COG2850	peptidyl-arginine hydroxylation
VY86_RS17265	COG2205	protein histidine kinase activity
VY86_RS17270	COG0745	RESPONSE REGULATOR receiver
VY86_RS17290	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
VY86_RS17295	COG2915	High frequency lysogenization protein hflD homolog
VY86_RS17300	COG0482	sulfurtransferase activity
VY86_RS17310	COG1187	pseudouridine synthase activity
VY86_RS17315	COG0538	isocitrate dehydrogenase activity
VY86_RS17330	COG1115	amino acid carrier protein
VY86_RS17335	COG3023	N-Acetylmuramoyl-L-alanine amidase
VY86_RS17350	COG0697	spore germination
VY86_RS17355	COG0561	phosphatase activity
VY86_RS17360	COG3708	Transcriptional regulator
VY86_RS17360	COG2207	Transcriptional regulator
VY86_RS17370	COG1113	amino acid transport
VY86_RS17385	COG0351	phosphomethylpyrimidine kinase
VY86_RS17390	COG1830	Aldolase
VY86_RS17410	COG0826	peptidase U32
VY86_RS17415	COG3422	double-strand break repair
VY86_RS17420	COG0745	RESPONSE REGULATOR receiver
VY86_RS17425	COG2205	protein histidine kinase activity
VY86_RS17430	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VY86_RS17435	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VY86_RS17440	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VY86_RS17450	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
VY86_RS17465	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
VY86_RS17470	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VY86_RS17475	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
VY86_RS17480	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
VY86_RS17485	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
VY86_RS17490	COG2233	PERMEase
VY86_RS17505	COG1486	melibiose metabolic process
VY86_RS17510	COG1447	Phosphotransferase system cellobiose-specific component IIA
VY86_RS17515	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
VY86_RS17530	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
VY86_RS17535	COG1393	Belongs to the ArsC family
VY86_RS17540	COG4783	chaperone-mediated protein folding
VY86_RS17545	COG0628	permease
VY86_RS17550	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
VY86_RS17555	COG2716	regulation of RNA biosynthetic process
VY86_RS17560	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VY86_RS17565	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
VY86_RS17575	COG3177	Filamentation induced by cAMP protein fic
VY86_RS17580	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
VY86_RS17585	COG1132	(ABC) transporter
VY86_RS17630	COG3409	Peptidoglycan-binding domain 1 protein
VY86_RS17630	COG3267	Type II secretory pathway component ExeA
VY86_RS17710	COG4373	Mu-like prophage FluMu protein gp28
VY86_RS17720	COG2369	cell adhesion
VY86_RS17895	COG2707	UPF0756 membrane protein
VY86_RS17900	COG1444	tRNA N-acetyltransferase activity
VY86_RS17910	COG1876	peptidase activity
VY86_RS17915	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VY86_RS17920	COG1393	Belongs to the ArsC family
VY86_RS17925	COG2197	response regulator
VY86_RS17945	COG1770	oligopeptidase
VY86_RS17950	COG1629	transport
VY86_RS17950	COG4206	TonB-dependent receptor
VY86_RS17955	COG1570	exodeoxyribonuclease VII activity
VY86_RS17960	COG0517	IMP dehydrogenase activity
VY86_RS17960	COG0516	GMP reductase activity
VY86_RS17965	COG0519	Catalyzes the synthesis of GMP from XMP
VY86_RS17965	COG0518	GMP synthase (glutamine-hydrolyzing) activity
VY86_RS17980	COG3328	transposase activity
VY86_RS17995	COG2226	methyltransferase
VY86_RS18000	COG1971	Probably functions as a manganese efflux pump
VY86_RS18005	COG4811	Protein of unknown function (DUF986)
VY86_RS18010	COG3716	PTS system mannose fructose sorbose family IID component
VY86_RS18015	COG3715	PTS system
VY86_RS18020	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VY86_RS18020	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
VY86_RS18025	COG1760	l-serine dehydratase
VY86_RS18030	COG0494	nUDIX hydrolase
VY86_RS18040	COG3140	Belongs to the UPF0181 family
VY86_RS18060	COG1528	Iron-storage protein
VY86_RS18065	COG2372	response to copper ion
VY86_RS18070	COG1276	copper resistance
VY86_RS18085	COG1956	GAF domain-containing protein
VY86_RS18090	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
VY86_RS18100	COG0501	Belongs to the peptidase M48B family
VY86_RS18105	COG1823	symporter activity
VY86_RS18110	COG1988	membrane-bound metal-dependent
VY86_RS18125	COG3001	Fructosamine kinase
VY86_RS18130	COG1108	ABC-type Mn2 Zn2 transport systems permease components
VY86_RS18135	COG1108	ABC-type Mn2 Zn2 transport systems permease components
VY86_RS18140	COG1121	(ABC) transporter
VY86_RS18145	COG0803	Belongs to the bacterial solute-binding protein 9 family
VY86_RS18155	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
VY86_RS18165	COG0291	Belongs to the bacterial ribosomal protein bL35 family
VY86_RS18170	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
VY86_RS18175	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
VY86_RS18180	COG0072	phenylalanine-tRNA ligase activity
VY86_RS18180	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VY86_RS18185	COG0776	regulation of translation
VY86_RS18190	COG4139	cobalamin transport
VY86_RS18195	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
VY86_RS18200	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
VY86_RS18205	COG0463	Glycosyl transferase, family 2
VY86_RS18210	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
VY86_RS18210	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VY86_RS18215	COG0726	polysaccharide deacetylase
VY86_RS18220	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
VY86_RS18225	COG2076	Multidrug Resistance protein
VY86_RS18230	COG2076	Multidrug Resistance protein
VY86_RS18235	COG0791	NLP P60 protein
VY86_RS18240	COG5464	transposase or invertase
VY86_RS18250	COG0577	efflux transmembrane transporter activity
VY86_RS18250	COG1136	(ABC) transporter
VY86_RS18255	COG0577	efflux transmembrane transporter activity
VY86_RS18255	COG1136	(ABC) transporter
VY86_RS18265	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VY86_RS18285	COG3335	DDE superfamily endonuclease
VY86_RS18295	COG2207	Transcriptional regulator
VY86_RS18305	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
VY86_RS18310	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VY86_RS18315	COG4558	Periplasmic binding protein
VY86_RS18320	COG3720	iron ion transport
VY86_RS18325	COG4771	TonB-dependent receptor
VY86_RS18335	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VY86_RS18340	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
VY86_RS18345	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
VY86_RS18345	COG0574	Belongs to the PEP-utilizing enzyme family
VY86_RS18350	COG0628	permease
VY86_RS18355	COG0277	FAD linked oxidase domain protein
VY86_RS18355	COG0247	lactate metabolic process
VY86_RS18360	COG2050	protein possibly involved in aromatic compounds catabolism
VY86_RS18415	COG5433	transposase activity
VY86_RS18425	COG0316	Belongs to the HesB IscA family
VY86_RS18430	COG0719	Fe-S assembly protein
VY86_RS18435	COG0396	ATPase activity
VY86_RS18440	COG0719	Fe-S assembly protein
VY86_RS18445	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
VY86_RS18450	COG2166	iron-sulfur cluster assembly
VY86_RS18455	COG1376	ErfK ybiS ycfS ynhG family protein
VY86_RS18455	COG1388	LysM domain
VY86_RS18460	COG4238	major outer membrane lipoprotein
VY86_RS18465	COG1024	Enoyl-CoA hydratase
VY86_RS18465	COG1250	3-hydroxyacyl-CoA dehydrogenase
VY86_RS18490	COG0534	Mate efflux family protein
VY86_RS18495	COG0307	riboflavin synthase, alpha
VY86_RS18510	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
VY86_RS18515	COG2814	Major facilitator Superfamily
VY86_RS18520	COG0583	DNA-binding transcription factor activity
VY86_RS18525	COG1609	Transcriptional regulator
VY86_RS18530	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
VY86_RS18535	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
VY86_RS18540	COG0346	lactoylglutathione lyase activity
VY86_RS18545	COG3313	Fe-S protein
VY86_RS18550	COG1846	Transcriptional regulator
VY86_RS18555	COG3133	Outer membrane lipoprotein
VY86_RS18560	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
VY86_RS18565	COG0259	pyridoxamine-phosphate oxidase activity
VY86_RS18570	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
VY86_RS18575	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
VY86_RS18600	COG4172	Belongs to the ABC transporter superfamily
VY86_RS18605	COG4171	peptide transport system, permease
VY86_RS18620	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
VY86_RS18625	COG1842	Phage shock protein A
VY86_RS18635	COG1983	PspC domain protein
VY86_RS18640	COG3106	COG3106 Predicted ATPase
VY86_RS18645	COG3768	UPF0283 membrane protein
VY86_RS18655	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
VY86_RS18660	COG4166	transmembrane transport
VY86_RS18665	COG0598	Magnesium transport protein CorA
VY86_RS18670	COG0037	tRNA processing
VY86_RS18715	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
VY86_RS18720	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VY86_RS18725	COG2186	Transcriptional regulator
VY86_RS18730	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VY86_RS18735	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
VY86_RS18740	COG3713	MltA-interacting MipA family protein
VY86_RS18750	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VY86_RS18755	COG3139	Protein of unknown function (DUF1315)
VY86_RS18760	COG1335	isochorismatase
VY86_RS18765	COG0252	asparaginase activity
VY86_RS18770	COG0616	signal peptide processing
VY86_RS18775	COG0778	Nitroreductase
VY86_RS18780	COG0709	Synthesizes selenophosphate from selenide and ATP
VY86_RS18790	COG0708	Exodeoxyribonuclease III
VY86_RS18795	COG0583	DNA-binding transcription factor activity
VY86_RS18915	COG0788	formyltetrahydrofolate deformylase activity
VY86_RS18920	COG3012	SEC-C Motif Domain Protein
VY86_RS18925	COG0745	RESPONSE REGULATOR receiver
VY86_RS18930	COG1210	Utp--glucose-1-phosphate uridylyltransferase
VY86_RS18950	COG1435	thymidine kinase activity
VY86_RS18955	COG1454	alcohol dehydrogenase
VY86_RS18955	COG1012	belongs to the aldehyde dehydrogenase family
VY86_RS18960	COG2095	MarC family integral membrane protein
VY86_RS18980	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VY86_RS18985	COG0444	Belongs to the ABC transporter superfamily
VY86_RS18995	COG0488	(ABC) transporter
VY86_RS19000	COG3099	Belongs to the UPF0263 family
VY86_RS19005	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VY86_RS19015	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
VY86_RS19015	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
VY86_RS19025	COG2917	probably involved in intracellular septation
VY86_RS19050	COG3047	cAMP biosynthetic process
VY86_RS19055	COG0159	tryptophan synthase activity
VY86_RS19060	COG0133	tryptophan synthase activity
VY86_RS19090	COG0009	L-threonylcarbamoyladenylate synthase
VY86_RS19095	COG1187	pseudouridine synthase activity
VY86_RS19100	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
VY86_RS19105	COG1028	Short-chain dehydrogenase reductase Sdr
VY86_RS19110	COG0616	signal peptide processing
VY86_RS19130	COG0583	DNA-binding transcription factor activity
VY86_RS19150	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
VY86_RS19155	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
VY86_RS19160	COG0284	orotidine-5'-phosphate decarboxylase activity
VY86_RS19165	COG0023	Translation Initiation Factor
VY86_RS19200	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VY86_RS19310	COG2015	COG2015, Alkyl sulfatase and related hydrolases
VY86_RS19315	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
VY86_RS19330	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
VY86_RS19340	COG4659	FMN binding
VY86_RS19360	COG4657	Part of a membrane complex involved in electron transport
VY86_RS19370	COG0673	inositol 2-dehydrogenase activity
VY86_RS19380	COG5433	transposase activity
VY86_RS19385	COG0385	Bile acid
VY86_RS19410	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
VY86_RS19430	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
VY86_RS19435	COG5339	Protein conserved in bacteria
VY86_RS19440	COG1482	cell wall glycoprotein biosynthetic process
VY86_RS19445	COG0114	fumarate hydratase activity
VY86_RS19450	COG5642	Protein of unknown function (DUF2384)
VY86_RS19480	COG1842	Phage shock protein A
VY86_RS19500	COG0754	glutathionylspermidine amidase activity
VY86_RS19505	COG3397	chitin binding
VY86_RS19525	COG0243	molybdopterin cofactor binding
VY86_RS19540	COG1028	Short-chain dehydrogenase reductase Sdr
VY86_RS19560	COG0604	alcohol dehydrogenase
VY86_RS19560	COG1028	Short-chain dehydrogenase reductase Sdr
VY86_RS19560	COG3321	synthase
VY86_RS19570	COG0814	amino acid
VY86_RS19590	COG4771	TonB-dependent receptor
VY86_RS19600	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
VY86_RS19620	COG1132	(ABC) transporter
VY86_RS19725	COG2197	response regulator
VY86_RS19730	COG2205	protein histidine kinase activity
VY86_RS19730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VY86_RS19810	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
VY86_RS19835	COG2140	Oxalate decarboxylase
VY86_RS19845	COG2115	Belongs to the xylose isomerase family
VY86_RS19855	COG0384	phenazine biosynthesis protein PhzF
VY86_RS19880	COG1136	(ABC) transporter
VY86_RS19880	COG0577	efflux transmembrane transporter activity
VY86_RS19890	COG0583	DNA-binding transcription factor activity
VY86_RS19895	COG1902	pentaerythritol trinitrate reductase activity
VY86_RS19900	COG0656	L-ascorbic acid biosynthetic process
VY86_RS19910	COG3191	aminopeptidase activity
VY86_RS19920	COG2986	histidine ammonia-lyase
VY86_RS19925	COG4221	oxidoreductase activity
VY86_RS19940	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
VY86_RS19945	COG1940	carbohydrate kinase activity
VY86_RS19985	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VY86_RS19990	COG3152	Membrane
VY86_RS19995	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
VY86_RS20005	COG1012	belongs to the aldehyde dehydrogenase family
VY86_RS20015	COG0446	pyridine nucleotide-disulphide oxidoreductase
VY86_RS20020	COG3384	dioxygenase
VY86_RS20025	COG1028	Short-chain dehydrogenase reductase Sdr
VY86_RS20030	COG2146	nitrite reductase [NAD(P)H] activity
VY86_RS20035	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
VY86_RS20040	COG4638	Rieske (2fe-2S)
VY86_RS20045	COG0583	DNA-binding transcription factor activity
VY86_RS20060	COG2313	pseudouridylate synthase activity
VY86_RS20065	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
VY86_RS20090	COG0546	phosphoglycolate phosphatase activity
VY86_RS20100	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
VY86_RS20105	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VY86_RS20110	COG0589	response to stress
VY86_RS20115	COG0829	nickel cation binding
VY86_RS20120	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
VY86_RS20125	COG0830	nickel cation binding
VY86_RS20135	COG0804	urea catabolic process
VY86_RS20140	COG0832	Belongs to the urease beta subunit family
VY86_RS20145	COG0831	urea catabolic process
VY86_RS20150	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
VY86_RS20165	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
VY86_RS20170	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
VY86_RS20180	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VY86_RS20185	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VY86_RS20195	COG0531	amino acid
VY86_RS20205	COG3539	Fimbrial protein
VY86_RS20210	COG3121	Chaperone
VY86_RS20225	COG1643	Atp-dependent helicase
VY86_RS20230	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
VY86_RS20235	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VY86_RS20240	COG3187	Heat shock protein
VY86_RS20250	COG2983	Belongs to the UPF0260 family
VY86_RS20255	COG0179	Fumarylacetoacetate (FAA) hydrolase
VY86_RS20260	COG3100	YcgL domain-containing protein
VY86_RS20265	COG0850	regulation of cytokinetic process
VY86_RS20270	COG2894	cell division
VY86_RS20275	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
VY86_RS20280	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
VY86_RS20285	COG0318	PFAM AMP-dependent synthetase and ligase
VY86_RS20295	COG3065	identical protein binding
VY86_RS20310	COG0540	Belongs to the ATCase OTCase family
VY86_RS20315	COG1199	ATP-dependent helicase activity
VY86_RS20320	COG0251	oxidation-reduction process
VY86_RS20335	COG2076	Multidrug Resistance protein
VY86_RS20340	COG2076	Multidrug Resistance protein
VY86_RS20345	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
VY86_RS20350	COG1737	Transcriptional regulator
VY86_RS20355	COG0469	pyruvate kinase activity
VY86_RS20370	COG1136	(ABC) transporter
VY86_RS20380	COG1560	Kdo2-lipid A biosynthetic process
VY86_RS20385	COG0739	heme binding
VY86_RS20390	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
VY86_RS20395	COG1121	(ABC) transporter
VY86_RS20400	COG1108	ABC-type Mn2 Zn2 transport systems permease components
VY86_RS20405	COG2255	four-way junction helicase activity
VY86_RS20410	COG0632	four-way junction helicase activity
VY86_RS20415	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
VY86_RS20420	COG0217	transcriptional regulatory protein
VY86_RS20425	COG0494	nUDIX hydrolase
VY86_RS20430	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
VY86_RS20435	COG3788	relative of glutathione S-transferase, MAPEG superfamily
VY86_RS20440	COG2226	methyltransferase
VY86_RS20445	COG0500	methyltransferase
VY86_RS20450	COG3142	Participates in the control of copper homeostasis
VY86_RS20455	COG3102	Protein conserved in bacteria
VY86_RS20475	COG3501	Rhs element vgr protein
VY86_RS20500	COG2353	YceI-like domain
VY86_RS20505	COG3038	cytochrome b561
VY86_RS20520	COG0018	arginyl-trna synthetase
VY86_RS20525	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
VY86_RS20535	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VY86_RS20540	COG0477	Major facilitator Superfamily
VY86_RS20550	COG3381	protein complex oligomerization
VY86_RS20555	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VY86_RS20590	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
VY86_RS20600	COG1073	alpha beta
VY86_RS20605	COG1012	belongs to the aldehyde dehydrogenase family
VY86_RS20610	COG2192	nodulation
VY86_RS20615	COG0659	secondary active sulfate transmembrane transporter activity
VY86_RS20620	COG2877	3-deoxy-8-phosphooctulonate synthase activity
VY86_RS20625	COG2912	Transglutaminase-like superfamily
VY86_RS20630	COG2890	protein-(glutamine-N5) methyltransferase activity
VY86_RS20635	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
VY86_RS20640	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
VY86_RS20645	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
VY86_RS20650	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
VY86_RS20655	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
VY86_RS20665	COG0193	aminoacyl-tRNA hydrolase activity
VY86_RS20670	COG0012	GTP binding
VY86_RS20695	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VY86_RS20700	COG1271	oxidase subunit
VY86_RS20705	COG1294	oxidase, subunit
VY86_RS20710	COG3850	Histidine kinase
VY86_RS20730	COG0531	amino acid
VY86_RS20735	COG1012	belongs to the aldehyde dehydrogenase family
VY86_RS20740	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VY86_RS20750	COG3938	Belongs to the proline racemase family
VY86_RS20775	COG2356	endonuclease I
VY86_RS20780	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
VY86_RS20795	COG0589	response to stress
VY86_RS20805	COG2197	response regulator
VY86_RS20810	COG0322	excinuclease ABC activity
VY86_RS20815	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
VY86_RS20840	COG5433	transposase activity
VY86_RS20865	COG3335	DDE superfamily endonuclease
VY86_RS20875	COG5301	cellulose 1,4-beta-cellobiosidase activity
VY86_RS20875	COG5301	cellulose 1,4-beta-cellobiosidase activity
VY86_RS20925	COG2197	response regulator
VY86_RS20935	COG2197	response regulator
VY86_RS20940	COG0626	cystathionine gamma-synthase activity
VY86_RS20955	COG1735	metal-dependent hydrolase with the TIM-barrel fold
VY86_RS20960	COG3457	Alanine racemase
VY86_RS20970	COG2188	Transcriptional regulator
VY86_RS20975	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VY86_RS20975	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
VY86_RS20975	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VY86_RS20980	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
VY86_RS20980	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VY86_RS21020	COG3675	Pfam Lipase (class 3)
VY86_RS21035	COG3501	Rhs element vgr protein
VY86_RS21060	COG0582	viral genome integration into host DNA
VY86_RS21085	COG3037	sugar-specific permease SgaT UlaA
VY86_RS21095	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VY86_RS21100	COG1609	Transcriptional regulator
VY86_RS21120	COG1902	pentaerythritol trinitrate reductase activity
VY86_RS21130	COG3048	D-serine ammonia-lyase activity
VY86_RS21135	COG2610	gluconate transmembrane transporter activity
VY86_RS21140	COG0583	DNA-binding transcription factor activity
VY86_RS21155	COG1113	amino acid transport
VY86_RS21160	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VY86_RS21165	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
VY86_RS21165	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
VY86_RS21165	COG0506	proline dehydrogenase activity
VY86_RS21175	COG1191	sigma factor activity
VY86_RS21205	COG1677	Flagellar hook-basal body complex protein FliE
VY86_RS21225	COG1157	protein secretion by the type III secretion system
VY86_RS21240	COG1580	Controls the rotational direction of flagella during chemotaxis
VY86_RS21245	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
VY86_RS21275	COG5433	transposase activity
VY86_RS21290	COG3668	Plasmid stabilization system
VY86_RS21390	COG3501	Rhs element vgr protein
VY86_RS21415	COG1706	bacterial-type flagellum-dependent cell motility
VY86_RS21420	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
VY86_RS21440	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
VY86_RS21445	COG1558	bacterial-type flagellum-dependent cell motility
VY86_RS21450	COG1815	bacterial-type flagellum-dependent cell motility
VY86_RS21515	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
VY86_RS21520	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
VY86_RS21595	COG4974	Belongs to the 'phage' integrase family
VY86_RS21650	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
VY86_RS21725	COG0300	oxidoreductase activity
VY86_RS21725	COG0318	PFAM AMP-dependent synthetase and ligase
VY86_RS21725	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
VY86_RS21725	COG3321	synthase
VY86_RS21725	COG1028	Short-chain dehydrogenase reductase Sdr
VY86_RS21730	COG0508	dehydrogenase complex catalyzes the overall conversion of
VY86_RS21735	COG0022	dehydrogenase e1 component
VY86_RS21740	COG2207	Transcriptional regulator
VY86_RS21770	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
VY86_RS21785	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
VY86_RS21790	COG0745	RESPONSE REGULATOR receiver
VY86_RS21795	COG2201	protein-glutamate methylesterase activity
VY86_RS21800	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
VY86_RS21805	COG0840	transmembrane signaling receptor activity
VY86_RS21810	COG0840	transmembrane signaling receptor activity
VY86_RS21815	COG0835	chemotaxis
VY86_RS21820	COG0643	Histidine kinase
VY86_RS21820	COG2198	Histidine kinase
VY86_RS21845	COG1285	pathogenesis
VY86_RS21885	COG0418	dihydroorotase activity
VY86_RS21895	COG2197	response regulator
VY86_RS21900	COG1054	Belongs to the UPF0176 family
VY86_RS21910	COG1560	Kdo2-lipid A biosynthetic process
VY86_RS21920	COG3093	addiction module antidote protein HigA
VY86_RS21945	COG3962	Belongs to the TPP enzyme family
VY86_RS21950	COG0673	inositol 2-dehydrogenase activity
VY86_RS21955	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VY86_RS21960	COG0673	inositol 2-dehydrogenase activity
VY86_RS21965	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VY86_RS21975	COG3718	enzyme involved in inositol metabolism
VY86_RS22000	COG5433	transposase activity
VY86_RS22020	COG1203	CRISPR-associated helicase, Cas3
VY86_RS22025	COG1518	maintenance of DNA repeat elements
VY86_RS22035	COG2920	part of a sulfur-relay system
VY86_RS22040	COG1254	Belongs to the acylphosphatase family
VY86_RS22045	COG3785	DNA binding
VY86_RS22055	COG0210	DNA helicase
VY86_RS22065	COG1289	transmembrane transporter activity
VY86_RS22070	COG3070	regulator of competence-specific genes
VY86_RS22075	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
VY86_RS22090	COG3120	sequence-specific DNA binding
VY86_RS22095	COG1067	ATP-dependent peptidase activity
VY86_RS22100	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VY86_RS22110	COG3009	Protein conserved in bacteria
VY86_RS22115	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
VY86_RS22115	COG3008	intermembrane lipid transfer
VY86_RS22120	COG2995	paraquat-inducible protein a
VY86_RS22125	COG0488	(ABC) transporter
VY86_RS22130	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VY86_RS22130	COG0116	Belongs to the methyltransferase superfamily
VY86_RS22160	COG0167	dihydroorotate dehydrogenase activity
VY86_RS22165	COG0308	aminopeptidase N
VY86_RS22170	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
VY86_RS22175	COG0017	Asparaginyl-tRNA synthetase
VY86_RS22180	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
VY86_RS22185	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
VY86_RS22190	COG1448	Aminotransferase
VY86_RS22195	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VY86_RS22200	COG3108	Peptidase M15
VY86_RS22205	COG2989	Protein conserved in bacteria
VY86_RS22215	COG3335	DDE superfamily endonuclease
VY86_RS22380	COG2885	chlorophyll binding
VY86_RS22460	COG5301	cellulose 1,4-beta-cellobiosidase activity
VY86_RS22515	COG0412	Dienelactone hydrolase
VY86_RS22550	COG3209	COG3209 Rhs family protein
VY86_RS22550	COG4104	PAAR repeat-containing protein
VY86_RS22575	COG5301	cellulose 1,4-beta-cellobiosidase activity
VY86_RS22635	COG0494	nUDIX hydrolase
VY86_RS22835	COG1028	Short-chain dehydrogenase reductase Sdr
VY86_RS22900	COG1028	Short-chain dehydrogenase reductase Sdr
VY86_RS23005	COG2274	protein secretion by the type I secretion system
VY86_RS23055	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
VY86_RS23055	COG2226	methyltransferase
VY86_RS23055	COG3433	isochorismatase activity
VY86_RS23125	COG0257	Belongs to the bacterial ribosomal protein bL36 family
VY86_RS23145	COG3423	Transcriptional regulator
VY86_RS23555	COG4890	Cyd operon protein YbgT
VY86_RS23705	COG0671	phosphoesterase, PA-phosphatase related
VY86_RS23860	COG3130	regulation of translation
VY86_RS23895	COG3344	reverse transcriptase
VY86_RS23975	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VY86_RS23980	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VY86_RS23995	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
VY86_RS24015	COG5301	cellulose 1,4-beta-cellobiosidase activity
VY86_RS24155	COG3642	lipopolysaccharide core region biosynthetic process
VY86_RS24265	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
VY86_RS24270	COG0512	Glutamine amidotransferase of anthranilate synthase