locus-tag	class	description
C6569_RS00025	COG0463	Glycosyl transferase, family 2
C6569_RS00045	COG4178	(ABC) transporter
C6569_RS00065	COG2204	response regulator
C6569_RS00085	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C6569_RS00085	COG0475	glutathione-regulated potassium exporter activity
C6569_RS00090	COG0312	modulator of DNA gyrase
C6569_RS00105	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C6569_RS00110	COG0109	protoheme IX farnesyltransferase activity
C6569_RS00120	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
C6569_RS00130	COG0612	Peptidase, M16
C6569_RS00135	COG0612	Peptidase, M16
C6569_RS00150	COG0745	RESPONSE REGULATOR receiver
C6569_RS00165	COG0596	Alpha beta hydrolase
C6569_RS00175	COG0151	Belongs to the GarS family
C6569_RS00180	COG1570	exodeoxyribonuclease VII activity
C6569_RS00185	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
C6569_RS00200	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C6569_RS00205	COG2808	Putative FMN-binding domain
C6569_RS00210	COG0840	transmembrane signaling receptor activity
C6569_RS00210	COG3290	protein histidine kinase activity
C6569_RS00215	COG0196	riboflavin kinase activity
C6569_RS00220	COG2030	dehydratase
C6569_RS00230	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C6569_RS00240	COG0657	acetylesterase activity
C6569_RS00245	COG4191	Histidine kinase
C6569_RS00245	COG2205	protein histidine kinase activity
C6569_RS00245	COG0745	RESPONSE REGULATOR receiver
C6569_RS00250	COG1970	mechanosensitive ion channel activity
C6569_RS00255	COG0742	ribosomal rna small subunit methyltransferase
C6569_RS00260	COG1187	pseudouridine synthase activity
C6569_RS00270	COG0590	tRNA wobble adenosine to inosine editing
C6569_RS00275	COG1178	ABC-type Fe3 transport system permease component
C6569_RS00280	COG1840	ABC-type Fe3 transport system, periplasmic component
C6569_RS00285	COG1218	3'(2'),5'-bisphosphate nucleotidase
C6569_RS00340	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C6569_RS00385	COG0330	HflC and HflK could
C6569_RS00390	COG0330	HflC and HflK could
C6569_RS00415	COG0254	rRNA binding
C6569_RS00420	COG1132	(ABC) transporter
C6569_RS00425	COG0454	-acetyltransferase
C6569_RS00425	COG0456	acetyltransferase
C6569_RS00440	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C6569_RS00460	COG0612	Peptidase, M16
C6569_RS00465	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C6569_RS00480	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C6569_RS00485	COG3023	N-Acetylmuramoyl-L-alanine amidase
C6569_RS00500	COG0275	rRNA processing
C6569_RS00515	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C6569_RS00525	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C6569_RS00530	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C6569_RS00540	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C6569_RS00545	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C6569_RS00550	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C6569_RS00565	COG1181	Belongs to the D-alanine--D-alanine ligase family
C6569_RS00570	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C6569_RS00575	COG0849	cell division
C6569_RS00580	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C6569_RS00590	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C6569_RS00605	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C6569_RS00620	COG0277	FAD linked oxidase domain protein
C6569_RS00640	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C6569_RS00645	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C6569_RS00645	COG4191	Histidine kinase
C6569_RS00650	COG0784	Response regulator, receiver
C6569_RS00650	COG3437	response regulator, receiver
C6569_RS00665	COG1376	ErfK ybiS ycfS ynhG family protein
C6569_RS00685	COG2202	Pas domain
C6569_RS00685	COG3920	Histidine kinase
C6569_RS00700	COG0667	Aldo Keto reductase
C6569_RS00705	COG3214	Protein conserved in bacteria
C6569_RS00715	COG1473	amidohydrolase
C6569_RS00720	COG0625	glutathione transferase activity
C6569_RS00730	COG1028	Short-chain dehydrogenase reductase Sdr
C6569_RS00735	COG1024	Enoyl-CoA hydratase
C6569_RS00735	COG1250	3-hydroxyacyl-CoA dehydrogenase
C6569_RS00760	COG1960	acyl-CoA dehydrogenase activity
C6569_RS00765	COG1028	Short-chain dehydrogenase reductase Sdr
C6569_RS00775	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C6569_RS00780	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
C6569_RS00780	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C6569_RS00810	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C6569_RS00835	COG1671	Belongs to the UPF0178 family
C6569_RS00880	COG1012	belongs to the aldehyde dehydrogenase family
C6569_RS00895	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C6569_RS00905	COG3842	ATPase activity
C6569_RS00910	COG0395	ABC-type sugar transport system, permease component
C6569_RS00915	COG1175	transmembrane transport
C6569_RS00935	COG0583	DNA-binding transcription factor activity
C6569_RS00945	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C6569_RS00955	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C6569_RS00960	COG1028	Short-chain dehydrogenase reductase Sdr
C6569_RS00965	COG0300	oxidoreductase activity
C6569_RS00970	COG0156	8-amino-7-oxononanoate synthase activity
C6569_RS01025	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C6569_RS01030	COG1137	ATPase activity
C6569_RS01035	COG1260	myo-inositol-1-phosphate synthase
C6569_RS01040	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C6569_RS01045	COG0438	transferase activity, transferring glycosyl groups
C6569_RS01070	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C6569_RS01080	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C6569_RS01090	COG1228	amidohydrolase
C6569_RS01095	COG0601	transmembrane transport
C6569_RS01100	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C6569_RS01110	COG0402	S-adenosylhomocysteine deaminase activity
C6569_RS01115	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C6569_RS01120	COG0346	lactoylglutathione lyase activity
C6569_RS01135	COG2815	serine threonine protein kinase
C6569_RS01135	COG0515	serine threonine protein kinase
C6569_RS01150	COG0384	phenazine biosynthesis protein PhzF
C6569_RS01155	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
C6569_RS01170	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C6569_RS01175	COG1309	transcriptional regulator
C6569_RS01180	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C6569_RS01200	COG0028	Belongs to the TPP enzyme family
C6569_RS01220	COG0154	amidase activity
C6569_RS01245	COG2814	Major facilitator Superfamily
C6569_RS01260	COG0656	L-ascorbic acid biosynthetic process
C6569_RS01270	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
C6569_RS01275	COG0424	maF-like protein
C6569_RS01280	COG2030	dehydratase
C6569_RS01315	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C6569_RS01320	COG1028	Short-chain dehydrogenase reductase Sdr
C6569_RS01325	COG0508	dehydrogenase complex catalyzes the overall conversion of
C6569_RS01335	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C6569_RS01350	COG0288	reversible hydration of carbon dioxide
C6569_RS01365	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C6569_RS01375	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
C6569_RS01380	COG1053	succinate dehydrogenase
C6569_RS01395	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C6569_RS01415	COG0354	folic acid binding
C6569_RS01420	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C6569_RS01425	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C6569_RS01465	COG0277	FAD linked oxidase domain protein
C6569_RS01480	COG1692	metallophosphoesterase
C6569_RS01490	COG2515	1-aminocyclopropane-1-carboxylate deaminase
C6569_RS01500	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C6569_RS01510	COG1024	Enoyl-CoA hydratase
C6569_RS01515	COG1960	acyl-CoA dehydrogenase activity
C6569_RS01520	COG0009	L-threonylcarbamoyladenylate synthase
C6569_RS01530	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C6569_RS01540	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C6569_RS01545	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C6569_RS01550	COG1741	Belongs to the pirin family
C6569_RS01565	COG0123	including yeast histone deacetylase and acetoin utilization protein
C6569_RS01570	COG1722	exodeoxyribonuclease VII activity
C6569_RS01580	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C6569_RS01585	COG1702	phosphate starvation-inducible protein PhoH
C6569_RS01590	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C6569_RS01595	COG1253	flavin adenine dinucleotide binding
C6569_RS01600	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C6569_RS01605	COG1396	sequence-specific DNA binding
C6569_RS01610	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C6569_RS01615	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C6569_RS01620	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C6569_RS01625	COG1120	ATPase activity
C6569_RS01630	COG1473	amidohydrolase
C6569_RS01650	COG0717	Belongs to the dCTP deaminase family
C6569_RS01680	COG0442	prolyl-tRNA aminoacylation
C6569_RS01690	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C6569_RS01710	COG0559	Belongs to the binding-protein-dependent transport system permease family
C6569_RS01725	COG0410	ABC transporter
C6569_RS01735	COG0546	phosphoglycolate phosphatase activity
C6569_RS01770	COG0501	Belongs to the peptidase M48B family
C6569_RS01780	COG0318	PFAM AMP-dependent synthetase and ligase
C6569_RS01910	COG3437	response regulator, receiver
C6569_RS01925	COG1376	ErfK ybiS ycfS ynhG family protein
C6569_RS01930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C6569_RS01945	COG0640	Transcriptional regulator
C6569_RS01950	COG4251	negative regulation of phosphorylation
C6569_RS01965	COG0408	coproporphyrinogen oxidase activity
C6569_RS01990	COG0667	Aldo Keto reductase
C6569_RS02005	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C6569_RS02015	COG4166	transmembrane transport
C6569_RS02025	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C6569_RS02030	COG4172	Belongs to the ABC transporter superfamily
C6569_RS02035	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C6569_RS02040	COG1028	Short-chain dehydrogenase reductase Sdr
C6569_RS02050	COG1028	Short-chain dehydrogenase reductase Sdr
C6569_RS02095	COG0411	ABC transporter
C6569_RS02110	COG0683	leucine binding
C6569_RS02115	COG2818	Glycosylase
C6569_RS02130	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
C6569_RS02240	COG1522	sequence-specific DNA binding
C6569_RS02250	COG1268	BioY protein
C6569_RS02255	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
C6569_RS02260	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C6569_RS02265	COG1802	Transcriptional regulator
C6569_RS02270	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C6569_RS02275	COG0247	lactate metabolic process
C6569_RS02275	COG0277	FAD linked oxidase domain protein
C6569_RS02285	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
C6569_RS02295	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C6569_RS02310	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C6569_RS02335	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
C6569_RS02340	COG0436	Aminotransferase
C6569_RS02375	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C6569_RS02385	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C6569_RS02410	COG3181	Tripartite tricarboxylate transporter family receptor
C6569_RS02425	COG0546	phosphoglycolate phosphatase activity
C6569_RS02435	COG1703	isobutyryl-CoA mutase activity
C6569_RS02440	COG0154	amidase activity
C6569_RS02445	COG0433	COG0433 Predicted ATPase
C6569_RS02470	COG4957	zinc ion binding
C6569_RS02480	COG2814	Major facilitator Superfamily
C6569_RS02495	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C6569_RS02505	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C6569_RS02515	COG2166	iron-sulfur cluster assembly
C6569_RS02525	COG2205	protein histidine kinase activity
C6569_RS02570	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
C6569_RS02575	COG2983	Belongs to the UPF0260 family
C6569_RS02585	COG0789	Transcriptional regulator
C6569_RS02625	COG4695	Portal protein
C6569_RS02630	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C6569_RS02650	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C6569_RS02655	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C6569_RS02670	COG0328	RNA-DNA hybrid ribonuclease activity
C6569_RS02675	COG4695	Portal protein
C6569_RS02810	COG4235	cytochrome complex assembly
C6569_RS02815	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
C6569_RS02820	COG1138	Cytochrome C-type biogenesis protein
C6569_RS02825	COG3088	subunit of a heme lyase
C6569_RS02830	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C6569_RS02835	COG0745	RESPONSE REGULATOR receiver
C6569_RS02845	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C6569_RS02850	COG2205	protein histidine kinase activity
C6569_RS02850	COG2202	Pas domain
C6569_RS02855	COG0308	aminopeptidase N
C6569_RS02875	COG1960	acyl-CoA dehydrogenase activity
C6569_RS02885	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
C6569_RS02900	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C6569_RS02905	COG0601	transmembrane transport
C6569_RS02910	COG0747	negative chemotaxis
C6569_RS02915	COG0154	amidase activity
C6569_RS02930	COG2195	Cleaves the N-terminal amino acid of tripeptides
C6569_RS02955	COG2010	Cytochrome c
C6569_RS02955	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C6569_RS02960	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C6569_RS02995	COG2094	Belongs to the DNA glycosylase MPG family
C6569_RS03000	COG3546	catalase activity
C6569_RS03040	COG3685	Protein conserved in bacteria
C6569_RS03075	COG0765	amino acid transport
C6569_RS03080	COG0765	amino acid transport
C6569_RS03085	COG4598	ABC transporter
C6569_RS03120	COG4297	protein containing double-stranded beta helix domain
C6569_RS03130	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C6569_RS03135	COG3842	ATPase activity
C6569_RS03165	COG1653	transport
C6569_RS03190	COG1175	transmembrane transport
C6569_RS03220	COG3842	ATPase activity
C6569_RS03235	COG1335	isochorismatase
C6569_RS03260	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
C6569_RS03270	COG5001	Diguanylate cyclase
C6569_RS03275	COG0747	negative chemotaxis
C6569_RS03290	COG1120	ATPase activity
C6569_RS03295	COG4774	siderophore transport
C6569_RS03315	COG0583	DNA-binding transcription factor activity
C6569_RS03320	COG1024	Enoyl-CoA hydratase
C6569_RS03325	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C6569_RS03345	COG0583	DNA-binding transcription factor activity
C6569_RS03350	COG0657	acetylesterase activity
C6569_RS03355	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C6569_RS03370	COG2130	NADP-dependent
C6569_RS03375	COG0745	RESPONSE REGULATOR receiver
C6569_RS03380	COG2205	protein histidine kinase activity
C6569_RS03385	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
C6569_RS03390	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
C6569_RS03395	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
C6569_RS03405	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C6569_RS03415	COG0730	response to heat
C6569_RS03425	COG0737	Belongs to the 5'-nucleotidase family
C6569_RS03440	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
C6569_RS03445	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
C6569_RS03450	COG4566	intracellular signal transduction
C6569_RS03455	COG4191	Histidine kinase
C6569_RS03460	COG0436	Aminotransferase
C6569_RS03470	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C6569_RS03475	COG0509	glycine decarboxylation via glycine cleavage system
C6569_RS03480	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C6569_RS03485	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C6569_RS03490	COG0693	protein deglycase activity
C6569_RS03505	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C6569_RS03515	COG1278	Cold shock
C6569_RS03520	COG0513	Belongs to the DEAD box helicase family
C6569_RS03525	COG2130	NADP-dependent
C6569_RS03530	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C6569_RS03535	COG2855	membrane
C6569_RS03545	COG2814	Major facilitator Superfamily
C6569_RS03570	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C6569_RS03580	COG0133	tryptophan synthase activity
C6569_RS03585	COG0135	phosphoribosylanthranilate isomerase activity
C6569_RS03590	COG2423	ornithine cyclodeaminase activity
C6569_RS03600	COG0776	regulation of translation
C6569_RS03605	COG0616	signal peptide processing
C6569_RS03615	COG0284	orotidine-5'-phosphate decarboxylase activity
C6569_RS03630	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C6569_RS03640	COG0539	negative regulation of cytoplasmic translation
C6569_RS03670	COG0126	phosphoglycerate kinase activity
C6569_RS03690	COG0352	thiamine-phosphate diphosphorylase activity
C6569_RS03700	COG0483	inositol monophosphate 1-phosphatase activity
C6569_RS03715	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C6569_RS03720	COG0560	Phosphoserine phosphatase
C6569_RS03720	COG3830	Belongs to the UPF0237 family
C6569_RS03725	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C6569_RS03760	COG0501	Belongs to the peptidase M48B family
C6569_RS03765	COG1704	LemA family
C6569_RS03770	COG4232	protein-disulfide reductase activity
C6569_RS03775	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C6569_RS03800	COG0318	PFAM AMP-dependent synthetase and ligase
C6569_RS03810	COG2205	protein histidine kinase activity
C6569_RS03820	COG2205	protein histidine kinase activity
C6569_RS03820	COG2202	Pas domain
C6569_RS03835	COG2084	Dehydrogenase
C6569_RS03840	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
C6569_RS03855	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C6569_RS03880	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C6569_RS03925	COG0546	phosphoglycolate phosphatase activity
C6569_RS03930	COG0840	transmembrane signaling receptor activity
C6569_RS03950	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C6569_RS03955	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
C6569_RS03975	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C6569_RS03980	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C6569_RS03980	COG1116	anion transmembrane transporter activity
C6569_RS03985	COG0402	S-adenosylhomocysteine deaminase activity
C6569_RS03995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C6569_RS04000	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C6569_RS04025	COG5265	(ABC) transporter
C6569_RS04035	COG3609	addiction module antidote protein, CC2985 family
C6569_RS04040	COG3668	Plasmid stabilization system
C6569_RS04045	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C6569_RS04055	COG0215	cysteine-tRNA ligase activity
C6569_RS04065	COG3045	CreA protein
C6569_RS04075	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C6569_RS04080	COG3181	Tripartite tricarboxylate transporter family receptor
C6569_RS04090	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
C6569_RS04095	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C6569_RS04105	COG0113	porphobilinogen synthase activity
C6569_RS04110	COG1960	acyl-CoA dehydrogenase activity
C6569_RS04115	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
C6569_RS04135	COG2989	Protein conserved in bacteria
C6569_RS04145	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C6569_RS04150	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C6569_RS04155	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C6569_RS04155	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C6569_RS04165	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C6569_RS04170	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C6569_RS04175	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
C6569_RS04185	COG0242	peptide deformylase activity
C6569_RS04205	COG0625	glutathione transferase activity
C6569_RS04245	COG4977	sequence-specific DNA binding
C6569_RS04250	COG0747	negative chemotaxis
C6569_RS04255	COG0601	transmembrane transport
C6569_RS04260	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C6569_RS04270	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C6569_RS04275	COG1120	ATPase activity
C6569_RS04280	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C6569_RS04295	COG0697	spore germination
C6569_RS04300	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C6569_RS04315	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C6569_RS04320	COG1024	Enoyl-CoA hydratase
C6569_RS04330	COG0604	alcohol dehydrogenase
C6569_RS04335	COG1733	regulation of RNA biosynthetic process
C6569_RS04345	COG0747	negative chemotaxis
C6569_RS04370	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C6569_RS04375	COG0444	Belongs to the ABC transporter superfamily
C6569_RS04385	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C6569_RS04390	COG0747	negative chemotaxis
C6569_RS04400	COG0154	amidase activity
C6569_RS04410	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C6569_RS04420	COG0601	transmembrane transport
C6569_RS04425	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C6569_RS04430	COG4172	Belongs to the ABC transporter superfamily
C6569_RS04440	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C6569_RS04460	COG0154	amidase activity
C6569_RS04465	COG1609	Transcriptional regulator
C6569_RS04470	COG0601	transmembrane transport
C6569_RS04475	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C6569_RS04480	COG0747	negative chemotaxis
C6569_RS04485	COG3258	Cytochrome c
C6569_RS04505	COG2010	Cytochrome c
C6569_RS04505	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C6569_RS04525	COG0765	amino acid transport
C6569_RS04535	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C6569_RS04540	COG4948	Mandelate Racemase Muconate Lactonizing
C6569_RS04545	COG0006	proline dipeptidase activity
C6569_RS04550	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C6569_RS04555	COG1530	ribonuclease E activity
C6569_RS04560	COG1376	ErfK ybiS ycfS ynhG family protein
C6569_RS04575	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C6569_RS04580	COG1283	sodium-dependent phosphate transmembrane transporter activity
C6569_RS04600	COG2233	PERMEase
C6569_RS04610	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
C6569_RS04615	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
C6569_RS04630	COG0739	heme binding
C6569_RS04635	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C6569_RS04650	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
C6569_RS04655	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C6569_RS04665	COG4115	mRNA cleavage
C6569_RS04670	COG2161	toxin-antitoxin pair type II binding
C6569_RS04675	COG0066	3-isopropylmalate dehydratase activity
C6569_RS04680	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C6569_RS04735	COG1053	succinate dehydrogenase
C6569_RS04740	COG0006	proline dipeptidase activity
C6569_RS04755	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C6569_RS04760	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C6569_RS04765	COG3591	Belongs to the peptidase S1B family
C6569_RS04765	COG1864	DNA RNA non-specific endonuclease
C6569_RS04800	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
C6569_RS04840	COG3243	poly(R)-hydroxyalkanoic acid synthase
C6569_RS04850	COG0559	Belongs to the binding-protein-dependent transport system permease family
C6569_RS04875	COG4191	Histidine kinase
C6569_RS04875	COG0784	Response regulator, receiver
C6569_RS04880	COG3920	Histidine kinase
C6569_RS04895	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
C6569_RS04900	COG3181	Tripartite tricarboxylate transporter family receptor
C6569_RS04910	COG3320	Male sterility
C6569_RS04910	COG1022	Amp-dependent synthetase and ligase
C6569_RS04915	COG1024	Enoyl-CoA hydratase
C6569_RS04950	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
C6569_RS04965	COG3181	Tripartite tricarboxylate transporter family receptor
C6569_RS05000	COG1959	2 iron, 2 sulfur cluster binding
C6569_RS05005	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
C6569_RS05010	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C6569_RS05015	COG4558	Periplasmic binding protein
C6569_RS05045	COG3246	L-lysine catabolic process to acetate
C6569_RS05050	COG1250	3-hydroxyacyl-CoA dehydrogenase
C6569_RS05060	COG1129	ABC transporter
C6569_RS05080	COG1028	Short-chain dehydrogenase reductase Sdr
C6569_RS05090	COG0277	FAD linked oxidase domain protein
C6569_RS05125	COG0425	Belongs to the sulfur carrier protein TusA family
C6569_RS05135	COG0489	protein tyrosine kinase activity
C6569_RS05165	COG3706	GGDEF domain
C6569_RS05170	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C6569_RS05170	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C6569_RS05180	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C6569_RS05180	COG0519	Catalyzes the synthesis of GMP from XMP
C6569_RS05190	COG1393	Belongs to the ArsC family
C6569_RS05210	COG1160	GTP binding
C6569_RS05225	COG0300	oxidoreductase activity
C6569_RS05230	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C6569_RS05235	COG1286	toxin biosynthetic process
C6569_RS05250	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C6569_RS05255	COG0305	Participates in initiation and elongation during chromosome replication
C6569_RS05265	COG0359	binds to the 23S rRNA
C6569_RS05275	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C6569_RS05280	COG0360	Binds together with S18 to 16S ribosomal RNA
C6569_RS05295	COG0523	cobalamin synthesis protein
C6569_RS05300	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C6569_RS05315	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C6569_RS05325	COG1561	YicC-like family, N-terminal region
C6569_RS05330	COG0194	GDP metabolic process
C6569_RS05340	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C6569_RS05355	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
C6569_RS05370	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C6569_RS05410	COG0488	(ABC) transporter
C6569_RS05415	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C6569_RS05425	COG0105	UTP biosynthetic process
C6569_RS05430	COG0243	molybdopterin cofactor binding
C6569_RS05445	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C6569_RS05450	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C6569_RS05455	COG0281	malic enzyme
C6569_RS05455	COG0280	phosphate acetyltransferase
C6569_RS05460	COG2200	EAL domain
C6569_RS05465	COG0741	lytic transglycosylase activity
C6569_RS05470	COG0024	Methionine aminopeptidase
C6569_RS05475	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C6569_RS05480	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C6569_RS05490	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C6569_RS05500	COG1573	uracil-dna glycosylase
C6569_RS05510	COG1758	RNA polymerase activity
C6569_RS05530	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C6569_RS05540	COG0736	holo-[acyl-carrier-protein] synthase activity
C6569_RS05555	COG0129	dihydroxy-acid dehydratase activity
C6569_RS05565	COG0321	lipoyl(octanoyl) transferase activity
C6569_RS05570	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C6569_RS05575	COG1846	Transcriptional regulator
C6569_RS05575	COG0456	acetyltransferase
C6569_RS05580	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C6569_RS05590	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C6569_RS05595	COG0302	gtp cyclohydrolase
C6569_RS05605	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C6569_RS05615	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C6569_RS05625	COG0778	Nitroreductase
C6569_RS05630	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C6569_RS05635	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C6569_RS05645	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C6569_RS05650	COG2301	Belongs to the HpcH HpaI aldolase family
C6569_RS05675	COG2201	protein-glutamate methylesterase activity
C6569_RS05680	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C6569_RS05685	COG1324	tolerance protein
C6569_RS05690	COG1028	Short-chain dehydrogenase reductase Sdr
C6569_RS05700	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C6569_RS05720	COG1960	acyl-CoA dehydrogenase activity
C6569_RS05735	COG1024	Enoyl-CoA hydratase
C6569_RS05745	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C6569_RS05770	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C6569_RS05795	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C6569_RS05805	COG1511	domain protein
C6569_RS05805	COG3264	Mechanosensitive ion channel
C6569_RS05815	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C6569_RS05825	COG0318	PFAM AMP-dependent synthetase and ligase
C6569_RS05835	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C6569_RS05870	COG0789	Transcriptional regulator
C6569_RS05885	COG0024	Methionine aminopeptidase
C6569_RS05900	COG1609	Transcriptional regulator
C6569_RS05905	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C6569_RS05910	COG0583	DNA-binding transcription factor activity
C6569_RS05930	COG2814	Major facilitator Superfamily
C6569_RS05935	COG4948	Mandelate Racemase Muconate Lactonizing
C6569_RS05945	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C6569_RS05950	COG1127	ABC transporter
C6569_RS05960	COG3218	ABC-type transport auxiliary lipoprotein component
C6569_RS05960	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C6569_RS05980	COG0633	Ferredoxin
C6569_RS05990	COG2062	phosphohistidine phosphatase, SixA
C6569_RS05995	COG3106	COG3106 Predicted ATPase
C6569_RS06000	COG3768	UPF0283 membrane protein
C6569_RS06030	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
C6569_RS06045	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C6569_RS06045	COG1648	precorrin-2 dehydrogenase activity
C6569_RS06050	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C6569_RS06060	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C6569_RS06070	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C6569_RS06075	COG0081	regulation of translation
C6569_RS06080	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C6569_RS06085	COG0222	ribosome binding
C6569_RS06090	COG0085	RNA polymerase activity
C6569_RS06095	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C6569_RS06105	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C6569_RS06110	COG0049	tRNA binding
C6569_RS06115	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C6569_RS06120	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C6569_RS06125	COG0051	transcription antitermination factor activity, RNA binding
C6569_RS06130	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C6569_RS06135	COG0088	Forms part of the polypeptide exit tunnel
C6569_RS06140	COG0089	rRNA binding
C6569_RS06145	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C6569_RS06150	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C6569_RS06155	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C6569_RS06160	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C6569_RS06165	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C6569_RS06170	COG0255	Belongs to the universal ribosomal protein uL29 family
C6569_RS06175	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C6569_RS06180	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C6569_RS06185	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C6569_RS06190	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C6569_RS06195	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C6569_RS06200	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C6569_RS06205	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C6569_RS06210	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C6569_RS06215	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C6569_RS06220	COG1841	ribosomal large subunit assembly
C6569_RS06225	COG0200	Binds to the 23S rRNA
C6569_RS06230	COG0201	protein transport
C6569_RS06235	COG0563	adenylate kinase activity
C6569_RS06240	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C6569_RS06245	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C6569_RS06250	COG0202	RNA polymerase activity
C6569_RS06255	COG0203	ribosomal protein L17
C6569_RS06275	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C6569_RS06280	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C6569_RS06285	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C6569_RS06305	COG0546	phosphoglycolate phosphatase activity
C6569_RS06315	COG0511	ligase activity, forming carbon-carbon bonds
C6569_RS06320	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C6569_RS06335	COG1902	pentaerythritol trinitrate reductase activity
C6569_RS06340	COG2814	Major facilitator Superfamily
C6569_RS06345	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
C6569_RS06370	COG0416	fatty acid biosynthetic process
C6569_RS06375	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C6569_RS06380	COG0776	regulation of translation
C6569_RS06420	COG0297	glycogen (starch) synthase activity
C6569_RS06440	COG0726	polysaccharide deacetylase
C6569_RS06445	COG4591	ABC-type transport system involved in lipoprotein release permease component
C6569_RS06450	COG1136	(ABC) transporter
C6569_RS06465	COG0436	Aminotransferase
C6569_RS06475	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C6569_RS06480	COG1278	Cold shock
C6569_RS06525	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
C6569_RS06545	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
C6569_RS06575	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
C6569_RS06580	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C6569_RS06580	COG1116	anion transmembrane transporter activity
C6569_RS06585	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C6569_RS06595	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C6569_RS06600	COG3604	Transcriptional regulator
C6569_RS06615	COG1012	belongs to the aldehyde dehydrogenase family
C6569_RS06620	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C6569_RS06655	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C6569_RS06675	COG3964	amidohydrolase
C6569_RS06695	COG2307	Protein conserved in bacteria
C6569_RS06695	COG2308	Evidence 4 Homologs of previously reported genes of
C6569_RS06705	COG1960	acyl-CoA dehydrogenase activity
C6569_RS06710	COG0730	response to heat
C6569_RS06720	COG5002	protein histidine kinase activity
C6569_RS06725	COG0704	Plays a role in the regulation of phosphate uptake
C6569_RS06730	COG0745	RESPONSE REGULATOR receiver
C6569_RS06735	COG0488	(ABC) transporter
C6569_RS06740	COG2249	NAD(P)H dehydrogenase (quinone) activity
C6569_RS06745	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C6569_RS06750	COG1496	oxidoreductase activity
C6569_RS06765	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C6569_RS06800	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C6569_RS06830	COG1309	transcriptional regulator
C6569_RS06845	COG1473	amidohydrolase
C6569_RS06850	COG1473	amidohydrolase
C6569_RS06855	COG1473	amidohydrolase
C6569_RS06860	COG0583	DNA-binding transcription factor activity
C6569_RS06865	COG0492	ferredoxin-NADP+ reductase activity
C6569_RS06875	COG1522	sequence-specific DNA binding
C6569_RS06880	COG0596	Alpha beta hydrolase
C6569_RS06880	COG2945	thiolester hydrolase activity
C6569_RS06910	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C6569_RS06915	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C6569_RS06940	COG0505	Belongs to the CarA family
C6569_RS06945	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C6569_RS06955	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C6569_RS06980	COG2133	pyrroloquinoline quinone binding
C6569_RS06990	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C6569_RS07010	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C6569_RS07015	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C6569_RS07025	COG1846	Transcriptional regulator
C6569_RS07030	COG0745	RESPONSE REGULATOR receiver
C6569_RS07080	COG3307	-O-antigen
C6569_RS07090	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C6569_RS07110	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C6569_RS07120	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C6569_RS07140	COG0482	sulfurtransferase activity
C6569_RS07145	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
C6569_RS07155	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
C6569_RS07160	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C6569_RS07165	COG4942	peptidase
C6569_RS07165	COG4942	peptidase
C6569_RS07175	COG1862	Preprotein translocase
C6569_RS07180	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C6569_RS07190	COG3737	Protein of unknown function (DUF498/DUF598)
C6569_RS07210	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C6569_RS07215	COG0629	single-stranded DNA binding
C6569_RS07235	COG2095	MarC family integral membrane protein
C6569_RS07240	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C6569_RS07250	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C6569_RS07275	COG2326	polyphosphate kinase activity
C6569_RS07300	COG1028	Short-chain dehydrogenase reductase Sdr
C6569_RS07310	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C6569_RS07315	COG2832	Protein of unknown function (DUF454)
C6569_RS07320	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C6569_RS07330	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C6569_RS07340	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C6569_RS07400	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C6569_RS07420	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C6569_RS07425	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C6569_RS07430	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C6569_RS07435	COG2943	transferase activity, transferring hexosyl groups
C6569_RS07440	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
C6569_RS07450	COG0318	PFAM AMP-dependent synthetase and ligase
C6569_RS07460	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C6569_RS07485	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C6569_RS07490	COG0508	dehydrogenase complex catalyzes the overall conversion of
C6569_RS07490	COG0022	dehydrogenase e1 component
C6569_RS07500	COG0508	dehydrogenase complex catalyzes the overall conversion of
C6569_RS07510	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C6569_RS07520	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C6569_RS07535	COG0300	oxidoreductase activity
C6569_RS07555	COG1686	Belongs to the peptidase S11 family
C6569_RS07560	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C6569_RS07565	COG0470	DNA polymerase III
C6569_RS07575	COG0084	hydrolase, TatD family'
C6569_RS07590	COG3956	TIGRFAM MazG family protein
C6569_RS07595	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C6569_RS07600	COG1923	regulation of RNA biosynthetic process
C6569_RS07605	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C6569_RS07615	COG2204	response regulator
C6569_RS07620	COG5000	phosphorelay sensor kinase activity
C6569_RS07625	COG2204	response regulator
C6569_RS07645	COG1546	Belongs to the CinA family
C6569_RS07655	COG3265	gluconokinase activity
C6569_RS07660	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C6569_RS07690	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C6569_RS07700	COG2351	hydroxyisourate hydrolase activity
C6569_RS07705	COG0659	secondary active sulfate transmembrane transporter activity
C6569_RS07710	COG1183	phosphatidylcholine synthase activity
C6569_RS07715	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C6569_RS07720	COG0679	Auxin Efflux Carrier
C6569_RS07730	COG2301	Belongs to the HpcH HpaI aldolase family
C6569_RS07755	COG0315	cyclic pyranopterin monophosphate synthase activity
C6569_RS07765	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C6569_RS07775	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C6569_RS07780	COG0372	Belongs to the citrate synthase family
C6569_RS07785	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C6569_RS07795	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C6569_RS07800	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C6569_RS07805	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C6569_RS07815	COG0750	zinc metalloprotease
C6569_RS07820	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C6569_RS07830	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C6569_RS07835	COG0233	cytoplasmic translational termination
C6569_RS07840	COG0528	UMP kinase activity
C6569_RS07860	COG0052	Belongs to the universal ribosomal protein uS2 family
C6569_RS07875	COG1028	Short-chain dehydrogenase reductase Sdr
C6569_RS07895	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C6569_RS07930	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C6569_RS07935	COG1984	allophanate hydrolase subunit 2
C6569_RS07940	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C6569_RS07985	COG0386	Belongs to the glutathione peroxidase family
C6569_RS07990	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
C6569_RS08005	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C6569_RS08020	COG1381	Involved in DNA repair and RecF pathway recombination
C6569_RS08035	COG0571	ribonuclease III activity
C6569_RS08040	COG0681	Belongs to the peptidase S26 family
C6569_RS08055	COG0625	glutathione transferase activity
C6569_RS08065	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C6569_RS08080	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
C6569_RS08085	COG1024	Enoyl-CoA hydratase
C6569_RS08120	COG2721	sulfolactate sulfo-lyase activity
C6569_RS08125	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C6569_RS08130	COG0830	nickel cation binding
C6569_RS08135	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
C6569_RS08140	COG0804	urea catabolic process
C6569_RS08150	COG0832	Belongs to the urease beta subunit family
C6569_RS08155	COG3813	Protein conserved in bacteria
C6569_RS08165	COG0831	urea catabolic process
C6569_RS08170	COG0829	nickel cation binding
C6569_RS08180	COG1183	phosphatidylcholine synthase activity
C6569_RS08190	COG0805	protein transport
C6569_RS08195	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C6569_RS08200	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C6569_RS08205	COG3842	ATPase activity
C6569_RS08210	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C6569_RS08215	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
C6569_RS08220	COG1472	Belongs to the glycosyl hydrolase 3 family
C6569_RS08230	COG0018	arginyl-trna synthetase
C6569_RS08235	COG0232	Belongs to the dGTPase family. Type 2 subfamily
C6569_RS08240	COG0316	Belongs to the HesB IscA family
C6569_RS08255	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C6569_RS08255	COG2124	cytochrome p450
C6569_RS08260	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
C6569_RS08265	COG0129	dihydroxy-acid dehydratase activity
C6569_RS08270	COG0525	valine-tRNA ligase activity
C6569_RS08285	COG1538	Outer membrane efflux protein
C6569_RS08290	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C6569_RS08310	COG0415	Belongs to the DNA photolyase family
C6569_RS08315	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C6569_RS08325	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C6569_RS08330	COG2897	thiosulfate sulfurtransferase activity
C6569_RS08335	COG1126	abc transporter atp-binding protein
C6569_RS08340	COG0765	amino acid transport
C6569_RS08345	COG4597	amino acid ABC transporter
C6569_RS08350	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C6569_RS08355	COG0626	cystathionine gamma-synthase activity
C6569_RS08385	COG0747	negative chemotaxis
C6569_RS08395	COG4608	Belongs to the ABC transporter superfamily
C6569_RS08400	COG0601	transmembrane transport
C6569_RS08405	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C6569_RS08420	COG0640	Transcriptional regulator
C6569_RS08435	COG3258	Cytochrome c
C6569_RS08455	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C6569_RS08475	COG0446	pyridine nucleotide-disulphide oxidoreductase
C6569_RS08500	COG1054	Belongs to the UPF0176 family
C6569_RS08535	COG5002	protein histidine kinase activity
C6569_RS08535	COG2198	Histidine kinase
C6569_RS08535	COG0784	Response regulator, receiver
C6569_RS08540	COG0745	RESPONSE REGULATOR receiver
C6569_RS08545	COG2204	response regulator
C6569_RS08560	COG0765	amino acid transport
C6569_RS08570	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C6569_RS08575	COG0726	polysaccharide deacetylase
C6569_RS08580	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C6569_RS08585	COG0402	S-adenosylhomocysteine deaminase activity
C6569_RS08600	COG1176	ABC-type spermidine putrescine transport system, permease component I
C6569_RS08605	COG3842	ATPase activity
C6569_RS08615	COG0154	amidase activity
C6569_RS08620	COG0640	Transcriptional regulator
C6569_RS08645	COG1960	acyl-CoA dehydrogenase activity
C6569_RS08650	COG1960	acyl-CoA dehydrogenase activity
C6569_RS08655	COG1024	Enoyl-CoA hydratase
C6569_RS08660	COG0683	leucine binding
C6569_RS08665	COG0559	Belongs to the binding-protein-dependent transport system permease family
C6569_RS08675	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C6569_RS08685	COG0318	PFAM AMP-dependent synthetase and ligase
C6569_RS08710	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
C6569_RS08715	COG0625	glutathione transferase activity
C6569_RS08720	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C6569_RS08725	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
C6569_RS08730	COG2080	2 iron, 2 sulfur cluster binding
C6569_RS08740	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C6569_RS08745	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
C6569_RS08750	COG2080	2 iron, 2 sulfur cluster binding
C6569_RS08760	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C6569_RS08765	COG0601	transmembrane transport
C6569_RS08770	COG4166	transmembrane transport
C6569_RS08820	COG1129	ABC transporter
C6569_RS08830	COG0683	leucine binding
C6569_RS08835	COG4948	Mandelate Racemase Muconate Lactonizing
C6569_RS08840	COG4948	Mandelate Racemase Muconate Lactonizing
C6569_RS08870	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C6569_RS08875	COG1494	fructose-1,6-bisphosphatase
C6569_RS08890	COG0436	Aminotransferase
C6569_RS08900	COG3243	poly(R)-hydroxyalkanoic acid synthase
C6569_RS08910	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C6569_RS08925	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
C6569_RS08930	COG0187	DNA topoisomerase II activity
C6569_RS08945	COG0513	Belongs to the DEAD box helicase family
C6569_RS08960	COG0316	Belongs to the HesB IscA family
C6569_RS08970	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C6569_RS08980	COG0396	ATPase activity
C6569_RS08985	COG0719	Fe-S assembly protein
C6569_RS08995	COG2945	thiolester hydrolase activity
C6569_RS09000	COG0540	Belongs to the ATCase OTCase family
C6569_RS09005	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C6569_RS09010	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C6569_RS09015	COG0758	DNA mediated transformation
C6569_RS09025	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C6569_RS09030	COG0557	exoribonuclease II activity
C6569_RS09055	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C6569_RS09060	COG0747	negative chemotaxis
C6569_RS09065	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C6569_RS09070	COG2877	3-deoxy-8-phosphooctulonate synthase activity
C6569_RS09075	COG0754	glutathionylspermidine amidase activity
C6569_RS09085	COG3766	membrane
C6569_RS09095	COG0504	CTP synthase activity
C6569_RS09105	COG0477	Major facilitator Superfamily
C6569_RS09110	COG0149	triose-phosphate isomerase activity
C6569_RS09120	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C6569_RS09130	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C6569_RS09135	COG0134	indole-3-glycerol-phosphate synthase activity
C6569_RS09150	COG1686	Belongs to the peptidase S11 family
C6569_RS09155	COG0484	heat shock protein binding
C6569_RS09175	COG0456	acetyltransferase
C6569_RS09180	COG0442	prolyl-tRNA aminoacylation
C6569_RS09190	COG0346	lactoylglutathione lyase activity
C6569_RS09205	COG1007	ATP synthesis coupled electron transport
C6569_RS09220	COG0713	ATP synthesis coupled electron transport
C6569_RS09230	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C6569_RS09240	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C6569_RS09260	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
C6569_RS09270	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
C6569_RS09275	COG0649	NAD binding
C6569_RS09280	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C6569_RS09290	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C6569_RS09295	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C6569_RS09310	COG0840	transmembrane signaling receptor activity
C6569_RS09310	COG2972	Histidine kinase
C6569_RS09315	COG3180	Ammonia monooxygenase
C6569_RS09330	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C6569_RS09335	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C6569_RS09340	COG0740	serine-type endopeptidase activity
C6569_RS09345	COG0544	peptidyl-prolyl cis-trans isomerase activity
C6569_RS09360	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C6569_RS09360	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C6569_RS09365	COG0347	Belongs to the P(II) protein family
C6569_RS09370	COG0174	glutamine synthetase
C6569_RS09405	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C6569_RS09410	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C6569_RS09415	COG0625	glutathione transferase activity
C6569_RS09420	COG0318	PFAM AMP-dependent synthetase and ligase
C6569_RS09430	COG1024	Enoyl-CoA hydratase
C6569_RS09435	COG1832	CoA-binding protein
C6569_RS09445	COG1612	heme a metabolic process
C6569_RS09455	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C6569_RS09490	COG1028	Short-chain dehydrogenase reductase Sdr
C6569_RS09495	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C6569_RS09505	COG0625	glutathione transferase activity
C6569_RS09540	COG1960	acyl-CoA dehydrogenase activity
C6569_RS09555	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C6569_RS09560	COG1254	Belongs to the acylphosphatase family
C6569_RS09580	COG5001	Diguanylate cyclase
C6569_RS09585	COG2239	Acts as a magnesium transporter
C6569_RS09595	COG0747	negative chemotaxis
C6569_RS09615	COG4770	biotin carboxylase activity
C6569_RS09625	COG1733	regulation of RNA biosynthetic process
C6569_RS09630	COG0248	Ppx GppA phosphatase
C6569_RS09645	COG0628	permease
C6569_RS09660	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C6569_RS09685	COG1522	sequence-specific DNA binding
C6569_RS09690	COG1028	Short-chain dehydrogenase reductase Sdr
C6569_RS09695	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C6569_RS09695	COG4651	solute:proton antiporter activity
C6569_RS09700	COG0747	negative chemotaxis
C6569_RS09710	COG1473	amidohydrolase
C6569_RS09720	COG0625	glutathione transferase activity
C6569_RS09745	COG0583	DNA-binding transcription factor activity
C6569_RS09765	COG0243	molybdopterin cofactor binding
C6569_RS09780	COG0443	Heat shock 70 kDa protein
C6569_RS09790	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C6569_RS09795	COG1028	Short-chain dehydrogenase reductase Sdr
C6569_RS09800	COG0747	negative chemotaxis
C6569_RS09805	COG0601	transmembrane transport
C6569_RS09810	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C6569_RS09815	COG4172	Belongs to the ABC transporter superfamily
C6569_RS09820	COG2072	flavoprotein involved in K transport
C6569_RS09840	COG0129	dihydroxy-acid dehydratase activity
C6569_RS09845	COG2223	nitrite transmembrane transporter activity
C6569_RS09855	COG0625	glutathione transferase activity
C6569_RS09870	COG0625	glutathione transferase activity
C6569_RS09885	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C6569_RS09905	COG0154	amidase activity
C6569_RS09910	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C6569_RS09930	COG1752	Esterase of the alpha-beta hydrolase superfamily
C6569_RS09935	COG0517	IMP dehydrogenase activity
C6569_RS09935	COG0516	GMP reductase activity
C6569_RS10015	COG2900	Belongs to the SlyX family
C6569_RS10020	COG1054	Belongs to the UPF0176 family
C6569_RS10025	COG2308	Evidence 4 Homologs of previously reported genes of
C6569_RS10055	COG3047	cAMP biosynthetic process
C6569_RS10060	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
C6569_RS10075	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C6569_RS10085	COG3932	Exopolysaccharide synthesis, ExoD
C6569_RS10090	COG3932	Exopolysaccharide synthesis, ExoD
C6569_RS10095	COG5425	PFAM Usg family protein
C6569_RS10130	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C6569_RS10130	COG3608	succinylglutamate desuccinylase aspartoacylase
C6569_RS10180	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C6569_RS10185	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C6569_RS10190	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C6569_RS10220	COG0683	leucine binding
C6569_RS10225	COG0785	Cytochrome C biogenesis protein
C6569_RS10230	COG3191	aminopeptidase activity
C6569_RS10260	COG3023	N-Acetylmuramoyl-L-alanine amidase
C6569_RS10270	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C6569_RS10300	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C6569_RS10305	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C6569_RS10330	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C6569_RS10340	COG0047	phosphoribosylformylglycinamidine synthase activity
C6569_RS10345	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C6569_RS10360	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C6569_RS10395	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C6569_RS10410	COG0538	isocitrate dehydrogenase activity
C6569_RS10435	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C6569_RS10440	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C6569_RS10445	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C6569_RS10450	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
C6569_RS10450	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
C6569_RS10475	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C6569_RS10480	COG1684	flagellar biosynthetic protein fliR
C6569_RS10485	COG1987	bacterial-type flagellum assembly
C6569_RS10490	COG1677	Flagellar hook-basal body complex protein FliE
C6569_RS10495	COG1558	bacterial-type flagellum-dependent cell motility
C6569_RS10500	COG1815	bacterial-type flagellum-dependent cell motility
C6569_RS10510	COG1338	Plays a role in the flagellum-specific transport system
C6569_RS10545	COG4786	Flagellar basal body rod
C6569_RS10550	COG4786	Flagellar basal body rod
C6569_RS10575	COG1706	bacterial-type flagellum-dependent cell motility
C6569_RS10600	COG0114	fumarate hydratase activity
C6569_RS10610	COG5443	negative regulation of bacterial-type flagellum assembly
C6569_RS10635	COG0542	response to heat
C6569_RS10675	COG1396	sequence-specific DNA binding
C6569_RS10680	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
C6569_RS10685	COG0351	phosphomethylpyrimidine kinase
C6569_RS10690	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
C6569_RS10710	COG2259	Doxx family
C6569_RS10715	COG0697	spore germination
C6569_RS10725	COG0728	peptidoglycan biosynthetic process
C6569_RS10735	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C6569_RS10745	COG0673	inositol 2-dehydrogenase activity
C6569_RS10765	COG0667	Aldo Keto reductase
C6569_RS10770	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C6569_RS10780	COG1086	Polysaccharide biosynthesis protein
C6569_RS10805	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C6569_RS10805	COG0546	phosphoglycolate phosphatase activity
C6569_RS10845	COG0438	transferase activity, transferring glycosyl groups
C6569_RS10845	COG1216	Glycosyl transferase, family 2
C6569_RS10855	COG0175	sulfate reduction
C6569_RS10880	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C6569_RS10895	COG0438	transferase activity, transferring glycosyl groups
C6569_RS10900	COG1088	dTDP-glucose 4,6-dehydratase activity
C6569_RS10905	COG1091	dTDP-4-dehydrorhamnose reductase activity
C6569_RS10915	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
C6569_RS10945	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
C6569_RS10950	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C6569_RS10955	COG0662	Cupin 2, conserved barrel domain protein
C6569_RS10955	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
C6569_RS10965	COG1028	Short-chain dehydrogenase reductase Sdr
C6569_RS10970	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C6569_RS10975	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C6569_RS10980	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C6569_RS10985	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C6569_RS11010	COG0154	amidase activity
C6569_RS11015	COG0747	negative chemotaxis
C6569_RS11020	COG0747	negative chemotaxis
C6569_RS11025	COG0601	transmembrane transport
C6569_RS11030	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C6569_RS11035	COG4608	Belongs to the ABC transporter superfamily
C6569_RS11040	COG0444	Belongs to the ABC transporter superfamily
C6569_RS11085	COG3158	transport of potassium into the cell
C6569_RS11100	COG0646	methionine synthase
C6569_RS11100	COG1410	methionine synthase
C6569_RS11120	COG2226	methyltransferase
C6569_RS11130	COG0346	lactoylglutathione lyase activity
C6569_RS11145	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C6569_RS11160	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
C6569_RS11180	COG0671	phosphoesterase, PA-phosphatase related
C6569_RS11190	COG3706	GGDEF domain
C6569_RS11200	COG0667	Aldo Keto reductase
C6569_RS11205	COG5001	Diguanylate cyclase
C6569_RS11215	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C6569_RS11220	COG0037	tRNA processing
C6569_RS11230	COG2885	chlorophyll binding
C6569_RS11250	COG0823	Involved in the tonB-independent uptake of proteins
C6569_RS11260	COG0848	biopolymer transport protein
C6569_RS11270	COG0824	Thioesterase
C6569_RS11280	COG2255	four-way junction helicase activity
C6569_RS11285	COG0632	four-way junction helicase activity
C6569_RS11290	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C6569_RS11295	COG1573	uracil-dna glycosylase
C6569_RS11320	COG1764	response to oxidative stress
C6569_RS11330	COG0752	glycyl-tRNA synthetase alpha subunit
C6569_RS11340	COG2852	Protein conserved in bacteria
C6569_RS11350	COG2813	Specifically methylates the guanine in position
C6569_RS11360	COG0142	geranyltranstransferase activity
C6569_RS11365	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C6569_RS11370	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C6569_RS11380	COG2890	protein-(glutamine-N5) methyltransferase activity
C6569_RS11390	COG0488	(ABC) transporter
C6569_RS11400	COG2267	carboxylic ester hydrolase activity
C6569_RS11415	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
C6569_RS11465	COG4208	sulfate ABC transporter
C6569_RS11470	COG3842	ATPase activity
C6569_RS11480	COG1176	ABC-type spermidine putrescine transport system, permease component I
C6569_RS11495	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
C6569_RS11505	COG2968	Membrane
C6569_RS11510	COG1132	(ABC) transporter
C6569_RS11525	COG1278	Cold shock
C6569_RS11535	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C6569_RS11550	COG1280	lysine exporter protein (LysE YggA)
C6569_RS11555	COG0640	Transcriptional regulator
C6569_RS11575	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C6569_RS11580	COG0358	DNA primase activity
C6569_RS11585	COG0314	molybdopterin synthase activity
C6569_RS11590	COG0625	glutathione transferase activity
C6569_RS11650	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C6569_RS11655	COG0193	aminoacyl-tRNA hydrolase activity
C6569_RS11660	COG0012	GTP binding
C6569_RS11665	COG2030	dehydratase
C6569_RS11675	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C6569_RS11685	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
C6569_RS11690	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C6569_RS11690	COG2857	Cytochrome c1
C6569_RS11695	COG2857	Cytochrome c1
C6569_RS11695	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C6569_RS11705	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C6569_RS11715	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
C6569_RS11725	COG1012	belongs to the aldehyde dehydrogenase family
C6569_RS11755	COG5001	Diguanylate cyclase
C6569_RS11755	COG3300	MHYT domain
C6569_RS11770	COG0494	nUDIX hydrolase
C6569_RS11780	COG0714	Associated with various cellular activities
C6569_RS11840	COG0745	RESPONSE REGULATOR receiver
C6569_RS11870	COG1280	lysine exporter protein (LysE YggA)
C6569_RS11880	COG0318	PFAM AMP-dependent synthetase and ligase
C6569_RS11885	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
C6569_RS11900	COG2201	protein-glutamate methylesterase activity
C6569_RS11905	COG0784	Response regulator, receiver
C6569_RS11905	COG0643	Histidine kinase
C6569_RS11905	COG2198	Histidine kinase
C6569_RS11915	COG2198	Histidine kinase
C6569_RS11915	COG0784	Response regulator, receiver
C6569_RS11915	COG0643	Histidine kinase
C6569_RS11930	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C6569_RS11985	COG3750	Belongs to the UPF0335 family
C6569_RS11990	COG0697	spore germination
C6569_RS12045	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C6569_RS12055	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C6569_RS12060	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C6569_RS12065	COG0328	RNA-DNA hybrid ribonuclease activity
C6569_RS12075	COG0678	peroxiredoxin activity
C6569_RS12075	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C6569_RS12085	COG1678	Uncharacterized ACR, COG1678
C6569_RS12090	COG0469	pyruvate kinase activity
C6569_RS12095	COG0596	Alpha beta hydrolase
C6569_RS12100	COG0457	Tetratricopeptide repeat
C6569_RS12105	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C6569_RS12110	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C6569_RS12120	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C6569_RS12125	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C6569_RS12150	COG0583	DNA-binding transcription factor activity
C6569_RS12165	COG0747	negative chemotaxis
C6569_RS12195	COG0564	pseudouridine synthase activity
C6569_RS12200	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C6569_RS12220	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C6569_RS12225	COG0581	inorganic phosphate transmembrane transporter activity
C6569_RS12230	COG0573	inorganic phosphate transmembrane transporter activity
C6569_RS12250	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C6569_RS12275	COG0217	transcriptional regulatory protein
C6569_RS12290	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C6569_RS12295	COG3321	synthase
C6569_RS12295	COG1028	Short-chain dehydrogenase reductase Sdr
C6569_RS12295	COG0604	alcohol dehydrogenase
C6569_RS12315	COG1064	alcohol dehydrogenase
C6569_RS12335	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C6569_RS12340	COG0789	Transcriptional regulator
C6569_RS12360	COG2733	membrane
C6569_RS12395	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C6569_RS12400	COG1166	arginine decarboxylase activity
C6569_RS12420	COG3046	protein related to deoxyribodipyrimidine photolyase
C6569_RS12425	COG1028	Short-chain dehydrogenase reductase Sdr
C6569_RS12435	COG2204	response regulator
C6569_RS12440	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C6569_RS12450	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C6569_RS12455	COG1766	The M ring may be actively involved in energy transduction
C6569_RS12465	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C6569_RS12485	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C6569_RS12490	COG0318	PFAM AMP-dependent synthetase and ligase
C6569_RS12520	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C6569_RS12525	COG0488	(ABC) transporter
C6569_RS12540	COG0471	metal ion transport
C6569_RS12540	COG3273	potassium ion transport
C6569_RS12545	COG1028	Short-chain dehydrogenase reductase Sdr
C6569_RS12555	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C6569_RS12560	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C6569_RS12565	COG0420	3'-5' exonuclease activity
C6569_RS12570	COG4717	serine-type aminopeptidase activity
C6569_RS12585	COG0601	transmembrane transport
C6569_RS12590	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C6569_RS12600	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C6569_RS12610	COG1082	Xylose isomerase domain protein TIM barrel
C6569_RS12630	COG0673	inositol 2-dehydrogenase activity
C6569_RS12640	COG3300	MHYT domain
C6569_RS12640	COG5001	Diguanylate cyclase
C6569_RS12695	COG2951	lytic endotransglycosylase activity
C6569_RS12705	COG2951	lytic endotransglycosylase activity
C6569_RS12715	COG0069	glutamate synthase activity
C6569_RS12715	COG0067	glutamate synthase
C6569_RS12715	COG0070	glutamate synthase
C6569_RS12735	COG0071	Belongs to the small heat shock protein (HSP20) family
C6569_RS12750	COG2267	carboxylic ester hydrolase activity
C6569_RS12760	COG2223	nitrite transmembrane transporter activity
C6569_RS12770	COG0667	Aldo Keto reductase
C6569_RS12775	COG0583	DNA-binding transcription factor activity
C6569_RS12795	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C6569_RS12800	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C6569_RS12810	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C6569_RS12815	COG1082	Xylose isomerase domain protein TIM barrel
C6569_RS12815	COG3185	4-Hydroxyphenylpyruvate dioxygenase
C6569_RS12820	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C6569_RS12835	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
C6569_RS12840	COG1028	Short-chain dehydrogenase reductase Sdr
C6569_RS12845	COG1846	Transcriptional regulator
C6569_RS12855	COG0318	PFAM AMP-dependent synthetase and ligase
C6569_RS12885	COG2205	protein histidine kinase activity
C6569_RS12900	COG0840	transmembrane signaling receptor activity
C6569_RS12945	COG2954	triphosphatase activity
C6569_RS12955	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C6569_RS12985	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C6569_RS12990	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C6569_RS13005	COG3938	Belongs to the proline racemase family
C6569_RS13035	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C6569_RS13040	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C6569_RS13050	COG1960	acyl-CoA dehydrogenase activity
C6569_RS13070	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
C6569_RS13085	COG3639	organic phosphonate transmembrane transporter activity
C6569_RS13090	COG3639	organic phosphonate transmembrane transporter activity
C6569_RS13095	COG2188	Transcriptional regulator
C6569_RS13100	COG3624	Phosphonate C-P lyase system protein PhnG
C6569_RS13105	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
C6569_RS13110	COG3626	phosphonate metabolism
C6569_RS13115	COG3627	carbon phosphorus lyase activity
C6569_RS13120	COG4107	phosphonate C-P lyase system protein PhnK
C6569_RS13125	COG4778	phosphonate C-P lyase system protein PhnL
C6569_RS13130	COG3454	Phosphonate metabolism
C6569_RS13135	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
C6569_RS13155	COG3852	Histidine kinase
C6569_RS13185	COG1136	(ABC) transporter
C6569_RS13185	COG0577	efflux transmembrane transporter activity
C6569_RS13190	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C6569_RS13225	COG1749	Flagellar hook protein flgE
C6569_RS13250	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C6569_RS13255	COG1595	DNA-templated transcription, initiation
C6569_RS13260	COG0583	DNA-binding transcription factor activity
C6569_RS13270	COG0861	Integral membrane protein TerC family
C6569_RS13280	COG0033	Phosphoglucomutase
C6569_RS13325	COG3485	protocatechuate 3,4-dioxygenase
C6569_RS13330	COG1802	Transcriptional regulator
C6569_RS13340	COG3181	Tripartite tricarboxylate transporter family receptor
C6569_RS13350	COG3971	2-oxopent-4-enoate hydratase activity
C6569_RS13365	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C6569_RS13370	COG3278	Belongs to the heme-copper respiratory oxidase family
C6569_RS13385	COG2010	Cytochrome c
C6569_RS13400	COG2217	Heavy metal translocating P-type atpase
C6569_RS13415	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C6569_RS13420	COG0842	Transport permease protein
C6569_RS13425	COG1131	(ABC) transporter
C6569_RS13430	COG0729	surface antigen
C6569_RS13445	COG0459	protein refolding
C6569_RS13450	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C6569_RS13455	COG5425	PFAM Usg family protein
C6569_RS13470	COG0587	DNA-directed DNA polymerase activity
C6569_RS13480	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C6569_RS13485	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C6569_RS13490	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C6569_RS13500	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C6569_RS13510	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C6569_RS13525	COG2885	chlorophyll binding
C6569_RS13530	COG4214	carbohydrate transport
C6569_RS13565	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C6569_RS13570	COG0601	transmembrane transport
C6569_RS13580	COG1132	(ABC) transporter
C6569_RS13595	COG1960	acyl-CoA dehydrogenase activity
C6569_RS13600	COG1028	Short-chain dehydrogenase reductase Sdr
C6569_RS13605	COG1012	belongs to the aldehyde dehydrogenase family
C6569_RS13620	COG1611	Belongs to the LOG family
C6569_RS13625	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
C6569_RS13630	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C6569_RS13635	COG1024	Enoyl-CoA hydratase
C6569_RS13640	COG1028	Short-chain dehydrogenase reductase Sdr
C6569_RS13645	COG0405	Gamma-glutamyltransferase
C6569_RS13655	COG0747	negative chemotaxis
C6569_RS13665	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C6569_RS13670	COG1120	ATPase activity
C6569_RS13675	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C6569_RS13680	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C6569_RS13690	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
C6569_RS13700	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C6569_RS13710	COG2738	Putative neutral zinc metallopeptidase
C6569_RS13730	COG0559	Belongs to the binding-protein-dependent transport system permease family
C6569_RS13740	COG1022	Amp-dependent synthetase and ligase
C6569_RS13775	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C6569_RS13795	COG1063	alcohol dehydrogenase
C6569_RS13810	COG0438	transferase activity, transferring glycosyl groups
C6569_RS13825	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C6569_RS13835	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C6569_RS13850	COG0028	Belongs to the TPP enzyme family
C6569_RS13860	COG1028	Short-chain dehydrogenase reductase Sdr
C6569_RS13865	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
C6569_RS13880	COG0840	transmembrane signaling receptor activity
C6569_RS13885	COG0523	cobalamin synthesis protein
C6569_RS13890	COG0803	Belongs to the bacterial solute-binding protein 9 family
C6569_RS13900	COG1121	(ABC) transporter
C6569_RS13920	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
C6569_RS13930	COG3395	kinase activity
C6569_RS13935	COG0235	Class ii aldolase
C6569_RS13940	COG3622	Belongs to the hyi family
C6569_RS13970	COG0129	dihydroxy-acid dehydratase activity
C6569_RS14000	COG0800	Aldolase
C6569_RS14015	COG1522	sequence-specific DNA binding
C6569_RS14035	COG4608	Belongs to the ABC transporter superfamily
C6569_RS14040	COG0444	Belongs to the ABC transporter superfamily
C6569_RS14045	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C6569_RS14055	COG0747	negative chemotaxis
C6569_RS14075	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C6569_RS14090	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C6569_RS14095	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C6569_RS14100	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C6569_RS14115	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
C6569_RS14130	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C6569_RS14135	COG0588	phosphoglycerate mutase activity
C6569_RS14150	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C6569_RS14155	COG3958	Transketolase
C6569_RS14160	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C6569_RS14165	COG0586	Pfam SNARE associated Golgi protein
C6569_RS14180	COG1522	sequence-specific DNA binding
C6569_RS14215	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C6569_RS14260	COG0739	heme binding
C6569_RS14265	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
C6569_RS14285	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
C6569_RS14290	COG0318	PFAM AMP-dependent synthetase and ligase
C6569_RS14295	COG1309	transcriptional regulator
C6569_RS14300	COG0318	PFAM AMP-dependent synthetase and ligase
C6569_RS14320	COG2081	HI0933 family
C6569_RS14325	COG0280	phosphate acetyltransferase
C6569_RS14325	COG0281	malic enzyme
C6569_RS14330	COG5001	Diguanylate cyclase
C6569_RS14335	COG1011	Hydrolase
C6569_RS14350	COG1320	monovalent cation:proton antiporter activity
C6569_RS14355	COG2212	antiporter activity
C6569_RS14370	COG1006	Multisubunit Na H antiporter MnhC subunit
C6569_RS14375	COG2111	Na H antiporter
C6569_RS14375	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C6569_RS14380	COG0189	ligase activity
C6569_RS14385	COG0792	nuclease activity
C6569_RS14390	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C6569_RS14415	COG4566	intracellular signal transduction
C6569_RS14430	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C6569_RS14445	COG0318	PFAM AMP-dependent synthetase and ligase
C6569_RS14450	COG0454	-acetyltransferase
C6569_RS14470	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C6569_RS14470	COG0072	phenylalanine-tRNA ligase activity
C6569_RS14475	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C6569_RS14480	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C6569_RS14485	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C6569_RS14500	COG0604	alcohol dehydrogenase
C6569_RS14510	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C6569_RS14510	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C6569_RS14520	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C6569_RS14535	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C6569_RS14540	COG0653	protein targeting
C6569_RS14555	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C6569_RS14570	COG1595	DNA-templated transcription, initiation
C6569_RS14585	COG2207	Transcriptional regulator
C6569_RS14585	COG1917	Cupin 2, conserved barrel domain protein
C6569_RS14600	COG1940	carbohydrate kinase activity
C6569_RS14605	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C6569_RS14610	COG0697	spore germination
C6569_RS14615	COG0268	Binds directly to 16S ribosomal RNA
C6569_RS14625	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C6569_RS14640	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C6569_RS14650	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C6569_RS14655	COG2860	membrane
C6569_RS14660	COG0124	histidyl-tRNA synthetase
C6569_RS14680	COG0583	DNA-binding transcription factor activity
C6569_RS14705	COG5001	Diguanylate cyclase
C6569_RS14705	COG3300	MHYT domain
C6569_RS14715	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C6569_RS14720	COG0459	protein refolding
C6569_RS14725	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
C6569_RS14745	COG1136	(ABC) transporter
C6569_RS14750	COG4591	ABC-type transport system involved in lipoprotein release permease component
C6569_RS14765	COG2321	neutral zinc metallopeptidase
C6569_RS14790	COG1051	belongs to the nudix hydrolase family
C6569_RS14810	COG4174	ABC transporter (Permease)
C6569_RS14815	COG4239	(ABC) transporter, permease
C6569_RS14830	COG4172	Belongs to the ABC transporter superfamily
C6569_RS14875	COG1238	metal cluster binding
C6569_RS14885	COG1968	undecaprenyl-diphosphatase activity
C6569_RS14895	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C6569_RS14905	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
C6569_RS14915	COG2223	nitrite transmembrane transporter activity
C6569_RS14920	COG3594	Acyltransferase
C6569_RS14930	COG0559	Belongs to the binding-protein-dependent transport system permease family
C6569_RS14940	COG1129	ABC transporter
C6569_RS14955	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
C6569_RS14960	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
C6569_RS14970	COG1802	Transcriptional regulator
C6569_RS14975	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C6569_RS14990	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
C6569_RS14995	COG1917	Cupin 2, conserved barrel domain protein
C6569_RS15000	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C6569_RS15005	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C6569_RS15035	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C6569_RS15050	COG1309	transcriptional regulator
C6569_RS15055	COG0318	PFAM AMP-dependent synthetase and ligase
C6569_RS15060	COG2267	carboxylic ester hydrolase activity
C6569_RS15085	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
C6569_RS15105	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
C6569_RS15145	COG2264	protein methyltransferase activity
C6569_RS15155	COG1598	PFAM Uncharacterised protein family UPF0150
C6569_RS15165	COG0210	DNA helicase
C6569_RS15170	COG1376	ErfK ybiS ycfS ynhG family protein
C6569_RS15190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C6569_RS15200	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
C6569_RS15215	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
C6569_RS15225	COG1960	acyl-CoA dehydrogenase activity
C6569_RS15230	COG1960	acyl-CoA dehydrogenase activity
C6569_RS15240	COG1028	Short-chain dehydrogenase reductase Sdr
C6569_RS15245	COG0183	Belongs to the thiolase family
C6569_RS15260	COG0730	response to heat
C6569_RS15265	COG2967	ApaG domain
C6569_RS15285	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C6569_RS15290	COG5328	Belongs to the UPF0262 family
C6569_RS15305	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C6569_RS15310	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C6569_RS15315	COG0028	Belongs to the TPP enzyme family
C6569_RS15335	COG1840	ABC-type Fe3 transport system, periplasmic component
C6569_RS15340	COG3181	Tripartite tricarboxylate transporter family receptor
C6569_RS15345	COG0596	Alpha beta hydrolase
C6569_RS15365	COG0473	3-isopropylmalate dehydrogenase activity
C6569_RS15370	COG0861	Integral membrane protein TerC family
C6569_RS15375	COG0861	Integral membrane protein TerC family
C6569_RS15380	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C6569_RS15390	COG0745	RESPONSE REGULATOR receiver
C6569_RS15395	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C6569_RS15400	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C6569_RS15410	COG1051	belongs to the nudix hydrolase family
C6569_RS15415	COG1335	isochorismatase
C6569_RS15420	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C6569_RS15425	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C6569_RS15430	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C6569_RS15440	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C6569_RS15445	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C6569_RS15460	COG1024	Enoyl-CoA hydratase
C6569_RS15460	COG1250	3-hydroxyacyl-CoA dehydrogenase
C6569_RS15465	COG0183	Belongs to the thiolase family
C6569_RS15470	COG1960	acyl-CoA dehydrogenase activity
C6569_RS15475	COG1960	acyl-CoA dehydrogenase activity
C6569_RS15520	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C6569_RS15520	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C6569_RS15530	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C6569_RS15540	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C6569_RS15545	COG0706	membrane insertase activity
C6569_RS15550	COG0594	ribonuclease P activity
C6569_RS15555	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C6569_RS15560	COG0625	glutathione transferase activity
C6569_RS15565	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C6569_RS15570	COG2226	methyltransferase
C6569_RS15575	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C6569_RS15585	COG1999	signal sequence binding
C6569_RS15595	COG1793	dna ligase
C6569_RS15635	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C6569_RS15650	COG2022	thiamine diphosphate biosynthetic process
C6569_RS15665	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C6569_RS15680	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
C6569_RS15690	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C6569_RS15720	COG1024	Enoyl-CoA hydratase
C6569_RS15725	COG1072	(Pantothenic acid kinase))
C6569_RS15745	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C6569_RS15765	COG1028	Short-chain dehydrogenase reductase Sdr
C6569_RS15775	COG0318	PFAM AMP-dependent synthetase and ligase
C6569_RS15780	COG0318	PFAM AMP-dependent synthetase and ligase
C6569_RS15785	COG0183	Belongs to the thiolase family
C6569_RS15790	COG0410	ABC transporter
C6569_RS15820	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C6569_RS15825	COG2223	nitrite transmembrane transporter activity
C6569_RS15830	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
C6569_RS15835	COG1140	nitrate reductase beta subunit
C6569_RS15840	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
C6569_RS15845	COG2181	nitrate reductase activity
C6569_RS15850	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C6569_RS15860	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C6569_RS15865	COG0288	reversible hydration of carbon dioxide
C6569_RS15905	COG1840	ABC-type Fe3 transport system, periplasmic component
C6569_RS15980	COG4251	negative regulation of phosphorylation
C6569_RS15980	COG3706	GGDEF domain
C6569_RS15980	COG2203	Gaf domain
C6569_RS15980	COG5001	Diguanylate cyclase
C6569_RS16010	COG4974	Belongs to the 'phage' integrase family
C6569_RS16065	COG5441	Belongs to the UPF0261 family
C6569_RS16070	COG5564	TIM-barrel signal transduction protein
C6569_RS16075	COG2268	Band 7 protein
C6569_RS16100	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C6569_RS16100	COG2080	2 iron, 2 sulfur cluster binding
C6569_RS16120	COG3618	amidohydrolase
C6569_RS16130	COG3386	PFAM SMP-30 Gluconolaconase
C6569_RS16155	COG1028	Short-chain dehydrogenase reductase Sdr
C6569_RS16165	COG3685	Protein conserved in bacteria
C6569_RS16180	COG1028	Short-chain dehydrogenase reductase Sdr
C6569_RS16190	COG2200	EAL domain
C6569_RS16200	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
C6569_RS16210	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C6569_RS16235	COG0183	Belongs to the thiolase family
C6569_RS16255	COG0625	glutathione transferase activity
C6569_RS16260	COG0477	Major facilitator Superfamily
C6569_RS16285	COG0071	Belongs to the small heat shock protein (HSP20) family
C6569_RS16290	COG3842	ATPase activity
C6569_RS16295	COG0395	ABC-type sugar transport system, permease component
C6569_RS16300	COG1175	transmembrane transport
C6569_RS16305	COG1653	transport
C6569_RS16310	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C6569_RS16315	COG0799	negative regulation of ribosome biogenesis
C6569_RS16360	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
C6569_RS16375	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C6569_RS16385	COG1643	Atp-dependent helicase
C6569_RS16395	COG1285	pathogenesis
C6569_RS16405	COG2358	TRAP transporter, solute receptor (TAXI family
C6569_RS16415	COG0242	peptide deformylase activity
C6569_RS16420	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C6569_RS16425	COG0101	tRNA pseudouridine synthase activity
C6569_RS16430	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C6569_RS16435	COG0628	permease
C6569_RS16440	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C6569_RS16455	COG0436	Aminotransferase
C6569_RS16465	COG2862	Uncharacterized protein family, UPF0114
C6569_RS16470	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C6569_RS16475	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C6569_RS16475	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C6569_RS16485	COG2205	protein histidine kinase activity
C6569_RS16490	COG0745	RESPONSE REGULATOR receiver
C6569_RS16500	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
C6569_RS16515	COG2816	NAD+ diphosphatase activity
C6569_RS16530	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C6569_RS16535	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C6569_RS16545	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C6569_RS16550	COG1904	glucuronate isomerase
C6569_RS16560	COG1797	cobyrinic acid a,c-diamide synthase activity
C6569_RS16565	COG2875	Belongs to the precorrin methyltransferase family
C6569_RS16580	COG2099	Precorrin-6x reductase
C6569_RS16630	COG1492	cobalamin metabolic process
C6569_RS16655	COG4178	(ABC) transporter
C6569_RS16665	COG4771	TonB-dependent receptor
C6569_RS16675	COG1960	acyl-CoA dehydrogenase activity
C6569_RS16690	COG4178	(ABC) transporter
C6569_RS16705	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C6569_RS16710	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
C6569_RS16720	COG0825	malonyl-CoA metabolic process
C6569_RS16725	COG4974	Belongs to the 'phage' integrase family
C6569_RS16740	COG2086	electron transfer activity
C6569_RS16745	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C6569_RS16750	COG1250	3-hydroxyacyl-CoA dehydrogenase
C6569_RS16755	COG3706	GGDEF domain
C6569_RS16770	COG2902	Dehydrogenase
C6569_RS16785	COG2835	tetraacyldisaccharide 4'-kinase activity
C6569_RS16800	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
C6569_RS16805	COG0501	Belongs to the peptidase M48B family
C6569_RS16815	COG1294	oxidase, subunit
C6569_RS16820	COG1271	oxidase subunit
C6569_RS16825	COG1414	Transcriptional regulator
C6569_RS16830	COG1028	Short-chain dehydrogenase reductase Sdr
C6569_RS16850	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C6569_RS16855	COG0235	Class ii aldolase
C6569_RS16875	COG1176	ABC-type spermidine putrescine transport system, permease component I
C6569_RS16880	COG3842	ATPase activity
C6569_RS16890	COG4221	oxidoreductase activity
C6569_RS16910	COG0798	PFAM Bile acid sodium symporter
C6569_RS16915	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C6569_RS16925	COG1393	Belongs to the ArsC family
C6569_RS16935	COG0019	diaminopimelate decarboxylase activity
C6569_RS16940	COG0288	reversible hydration of carbon dioxide
C6569_RS16950	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C6569_RS16955	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
C6569_RS16970	COG4953	penicillin-binding protein 1C
C6569_RS16975	COG2373	Large extracellular alpha-helical protein
C6569_RS16980	COG0022	dehydrogenase e1 component
C6569_RS16985	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C6569_RS17015	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C6569_RS17030	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C6569_RS17035	COG2204	response regulator
C6569_RS17040	COG0037	tRNA processing
C6569_RS17040	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
C6569_RS17075	COG0419	ATPase involved in DNA repair
C6569_RS17110	COG2884	Cell division ATP-binding protein ftsE
C6569_RS17130	COG0004	ammonium transporteR
C6569_RS17135	COG0347	Belongs to the P(II) protein family
C6569_RS17140	COG1946	Acyl-CoA thioesterase
C6569_RS17145	COG1177	transmembrane transport
C6569_RS17150	COG1176	ABC-type spermidine putrescine transport system, permease component I
C6569_RS17155	COG3842	ATPase activity
C6569_RS17165	COG0402	S-adenosylhomocysteine deaminase activity
C6569_RS17175	COG1116	anion transmembrane transporter activity
C6569_RS17180	COG1546	Belongs to the CinA family
C6569_RS17180	COG1058	Belongs to the CinA family
C6569_RS17190	COG1024	Enoyl-CoA hydratase
C6569_RS17195	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C6569_RS17205	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C6569_RS17215	COG1028	Short-chain dehydrogenase reductase Sdr
C6569_RS17220	COG0322	excinuclease ABC activity
C6569_RS17240	COG1253	flavin adenine dinucleotide binding
C6569_RS17250	COG0405	Gamma-glutamyltransferase
C6569_RS17265	COG0393	Putative heavy-metal-binding
C6569_RS17270	COG0138	bifunctional purine biosynthesis protein purh
C6569_RS17290	COG1116	anion transmembrane transporter activity
C6569_RS17295	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C6569_RS17305	COG1872	DUF167
C6569_RS17310	COG0140	phosphoribosyl-ATP diphosphatase activity
C6569_RS17315	COG0697	spore germination
C6569_RS17320	COG0484	heat shock protein binding
C6569_RS17325	COG0443	Heat shock 70 kDa protein
C6569_RS17345	COG1420	regulation of RNA biosynthetic process
C6569_RS17350	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C6569_RS17355	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C6569_RS17365	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C6569_RS17410	COG2130	NADP-dependent
C6569_RS17415	COG2514	catechol 2,3-dioxygenase activity
C6569_RS17420	COG1253	flavin adenine dinucleotide binding
C6569_RS17425	COG2171	N-acyltransferase activity
C6569_RS17440	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C6569_RS17450	COG1522	sequence-specific DNA binding
C6569_RS17465	COG1234	tRNA 3'-trailer cleavage
C6569_RS17470	COG0295	cytidine deaminase activity
C6569_RS17475	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
C6569_RS17480	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C6569_RS17490	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
C6569_RS17495	COG1132	(ABC) transporter
C6569_RS17505	COG0793	Belongs to the peptidase S41A family
C6569_RS17520	COG1388	LysM domain
C6569_RS17520	COG1376	ErfK ybiS ycfS ynhG family protein
C6569_RS17530	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C6569_RS17535	COG1063	alcohol dehydrogenase
C6569_RS17540	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
C6569_RS17565	COG1335	isochorismatase
C6569_RS17570	COG2354	Protein conserved in bacteria
C6569_RS17575	COG0028	Belongs to the TPP enzyme family
C6569_RS17590	COG1028	Short-chain dehydrogenase reductase Sdr
C6569_RS17620	COG1414	Transcriptional regulator
C6569_RS17635	COG2124	cytochrome p450
C6569_RS17640	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C6569_RS17650	COG0446	pyridine nucleotide-disulphide oxidoreductase
C6569_RS17650	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C6569_RS17665	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C6569_RS17670	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C6569_RS17685	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C6569_RS17720	COG0181	hydroxymethylbilane synthase activity
C6569_RS17730	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C6569_RS17745	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C6569_RS17755	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C6569_RS17770	COG1028	Short-chain dehydrogenase reductase Sdr
C6569_RS17780	COG0745	RESPONSE REGULATOR receiver
C6569_RS17785	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C6569_RS17790	COG3852	Histidine kinase
C6569_RS17800	COG0745	RESPONSE REGULATOR receiver
C6569_RS17810	COG3852	Histidine kinase
C6569_RS17815	COG4581	dead DEAH box helicase
C6569_RS17820	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C6569_RS17825	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C6569_RS17830	COG2813	Specifically methylates the guanine in position
C6569_RS17830	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C6569_RS17850	COG1028	Short-chain dehydrogenase reductase Sdr
C6569_RS17855	COG0243	molybdopterin cofactor binding
C6569_RS17860	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C6569_RS17865	COG1116	anion transmembrane transporter activity
C6569_RS17870	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C6569_RS17875	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C6569_RS17880	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C6569_RS17885	COG3707	response regulator
C6569_RS17890	COG1028	Short-chain dehydrogenase reductase Sdr
C6569_RS17895	COG4106	trans-aconitate 2-methyltransferase activity
C6569_RS17900	COG0523	cobalamin synthesis protein
C6569_RS17910	COG1686	Belongs to the peptidase S11 family
C6569_RS17915	COG0183	Belongs to the thiolase family
C6569_RS17920	COG3191	aminopeptidase activity
C6569_RS17925	COG0521	Mo-molybdopterin cofactor biosynthetic process
C6569_RS17935	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C6569_RS17940	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C6569_RS17945	COG3743	rRNA binding
C6569_RS17945	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C6569_RS17955	COG1902	pentaerythritol trinitrate reductase activity
C6569_RS17965	COG2271	Major facilitator Superfamily
C6569_RS17970	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
C6569_RS17975	COG3387	PFAM Glycoside hydrolase 15-related
C6569_RS17995	COG0495	leucyl-tRNA aminoacylation
C6569_RS18015	COG0357	Ribosomal RNA small subunit methyltransferase G
C6569_RS18020	COG0445	tRNA wobble uridine modification
C6569_RS18025	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C6569_RS18030	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C6569_RS18035	COG1981	membrane
C6569_RS18040	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C6569_RS18045	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
C6569_RS18050	COG0424	maF-like protein
C6569_RS18055	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C6569_RS18060	COG0237	dephospho-CoA kinase activity
C6569_RS18070	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C6569_RS18080	COG1201	RNA secondary structure unwinding
C6569_RS18090	COG2003	Belongs to the UPF0758 family
C6569_RS18095	COG0604	alcohol dehydrogenase
C6569_RS18115	COG0318	PFAM AMP-dependent synthetase and ligase
C6569_RS18115	COG0204	Acyl-transferase
C6569_RS18120	COG1074	ATP-dependent DNA helicase activity
C6569_RS18125	COG2887	Belongs to the helicase family. UvrD subfamily
C6569_RS18130	COG0747	negative chemotaxis
C6569_RS18140	COG2084	Dehydrogenase
C6569_RS18185	COG3195	allantoin biosynthetic process
C6569_RS18185	COG3648	Uricase
C6569_RS18190	COG0402	S-adenosylhomocysteine deaminase activity
C6569_RS18195	COG1228	amidohydrolase
C6569_RS18210	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C6569_RS18215	COG0183	Belongs to the thiolase family
C6569_RS18225	COG1028	Short-chain dehydrogenase reductase Sdr
C6569_RS18230	COG1960	acyl-CoA dehydrogenase activity
C6569_RS18235	COG2030	dehydratase
C6569_RS18260	COG1024	Enoyl-CoA hydratase
C6569_RS18270	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C6569_RS18280	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C6569_RS18305	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C6569_RS18320	COG3916	Acyl-homoserine-lactone synthase
C6569_RS18325	COG2197	response regulator
C6569_RS18340	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C6569_RS18360	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C6569_RS18365	COG1137	ATPase activity
C6569_RS18380	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
C6569_RS18390	COG0583	DNA-binding transcription factor activity
C6569_RS18395	COG4336	lyase activity
C6569_RS18420	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
C6569_RS18425	COG1132	(ABC) transporter
C6569_RS18430	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C6569_RS18455	COG1028	Short-chain dehydrogenase reductase Sdr
C6569_RS18480	COG1376	ErfK ybiS ycfS ynhG family protein
C6569_RS18485	COG1196	nuclear chromosome segregation
C6569_RS18520	COG0356	it plays a direct role in the translocation of protons across the membrane
C6569_RS18525	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C6569_RS18530	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C6569_RS18535	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C6569_RS18550	COG0312	modulator of DNA gyrase
C6569_RS18570	COG1519	Transferase
C6569_RS18575	COG1663	tetraacyldisaccharide 4'-kinase activity
C6569_RS18590	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C6569_RS18595	COG0406	alpha-ribazole phosphatase activity
C6569_RS18610	COG1194	a g-specific adenine glycosylase
C6569_RS18615	COG1272	protein, Hemolysin III
C6569_RS18625	COG3485	protocatechuate 3,4-dioxygenase
C6569_RS18630	COG3485	protocatechuate 3,4-dioxygenase
C6569_RS18635	COG0183	Belongs to the thiolase family
C6569_RS18640	COG0747	negative chemotaxis
C6569_RS18645	COG0601	transmembrane transport
C6569_RS18650	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C6569_RS18685	COG1522	sequence-specific DNA binding
C6569_RS18690	COG4166	transmembrane transport
C6569_RS18715	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C6569_RS18740	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C6569_RS18745	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C6569_RS18750	COG2852	Protein conserved in bacteria
C6569_RS18755	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C6569_RS18760	COG3178	'Phosphotransferase
C6569_RS18765	COG2205	protein histidine kinase activity
C6569_RS18770	COG0456	acetyltransferase
C6569_RS18780	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
C6569_RS18795	COG0481	GTPase activity
C6569_RS18805	COG1414	Transcriptional regulator
C6569_RS18810	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C6569_RS18830	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C6569_RS18835	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C6569_RS18840	COG1079	Belongs to the binding-protein-dependent transport system permease family
C6569_RS18845	COG4603	Belongs to the binding-protein-dependent transport system permease family
C6569_RS18850	COG3845	ABC transporter
C6569_RS18855	COG0590	tRNA wobble adenosine to inosine editing
C6569_RS18860	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C6569_RS18865	COG0765	amino acid transport
C6569_RS18870	COG4597	amino acid ABC transporter
C6569_RS18875	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C6569_RS18885	COG0180	Tryptophanyl-tRNA synthetase
C6569_RS18935	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
C6569_RS18945	COG1960	acyl-CoA dehydrogenase activity
C6569_RS18955	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C6569_RS18960	COG0439	Biotin carboxylase
C6569_RS18965	COG1024	Enoyl-CoA hydratase
C6569_RS18975	COG3246	L-lysine catabolic process to acetate
C6569_RS19010	COG1960	acyl-CoA dehydrogenase activity
C6569_RS19035	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
C6569_RS19050	COG2205	protein histidine kinase activity
C6569_RS19065	COG1175	transmembrane transport
C6569_RS19070	COG1653	transport
C6569_RS19075	COG3842	ATPase activity
C6569_RS19085	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
C6569_RS19135	COG3383	formate dehydrogenase (NAD+) activity
C6569_RS19135	COG0243	molybdopterin cofactor binding
C6569_RS19140	COG0437	4 iron, 4 sulfur cluster binding
C6569_RS19145	COG2864	formate dehydrogenase
C6569_RS19150	COG1763	Mo-molybdopterin cofactor biosynthetic process
C6569_RS19155	COG0303	'Molybdopterin
C6569_RS19160	COG0746	molybdenum cofactor guanylyltransferase activity
C6569_RS19175	COG1126	abc transporter atp-binding protein
C6569_RS19195	COG0303	'Molybdopterin
C6569_RS19205	COG0156	8-amino-7-oxononanoate synthase activity
C6569_RS19210	COG0235	Class ii aldolase
C6569_RS19215	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C6569_RS19255	COG0135	phosphoribosylanthranilate isomerase activity
C6569_RS19260	COG1131	(ABC) transporter
C6569_RS19265	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C6569_RS19275	COG3265	gluconokinase activity
C6569_RS19280	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
C6569_RS19285	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C6569_RS19290	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C6569_RS19300	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C6569_RS19310	COG0131	Imidazoleglycerol-phosphate dehydratase
C6569_RS19320	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C6569_RS19325	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C6569_RS19335	COG0107	imidazoleglycerol-phosphate synthase activity
C6569_RS19360	COG3800	Transcriptional regulator
C6569_RS19360	COG1396	sequence-specific DNA binding
C6569_RS19365	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C6569_RS19420	COG4964	Belongs to the GSP D family
C6569_RS19455	COG2814	Major facilitator Superfamily
C6569_RS19470	COG0640	Transcriptional regulator
C6569_RS19485	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C6569_RS19485	COG0574	Belongs to the PEP-utilizing enzyme family
C6569_RS19490	COG1703	isobutyryl-CoA mutase activity
C6569_RS19530	COG1396	sequence-specific DNA binding
C6569_RS19545	COG2814	Major facilitator Superfamily
C6569_RS19590	COG1230	cation diffusion facilitator family transporter
C6569_RS19595	COG2072	flavoprotein involved in K transport
C6569_RS19605	COG1999	signal sequence binding
C6569_RS19610	COG1914	H( )-stimulated, divalent metal cation uptake system
C6569_RS19640	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C6569_RS19650	COG3621	Patatin-like phospholipase
C6569_RS19685	COG1335	isochorismatase
C6569_RS19695	COG0747	negative chemotaxis
C6569_RS19700	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C6569_RS19705	COG1522	sequence-specific DNA binding
C6569_RS19760	COG1278	Cold shock
C6569_RS19785	COG0402	S-adenosylhomocysteine deaminase activity
C6569_RS19795	COG2249	NAD(P)H dehydrogenase (quinone) activity
C6569_RS19805	COG2084	Dehydrogenase
C6569_RS19810	COG0395	ABC-type sugar transport system, permease component
C6569_RS19815	COG1175	transmembrane transport
C6569_RS19825	COG3842	ATPase activity
C6569_RS19830	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C6569_RS19840	COG0330	HflC and HflK could
C6569_RS19845	COG0803	Belongs to the bacterial solute-binding protein 9 family
C6569_RS19850	COG1121	(ABC) transporter
C6569_RS19855	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C6569_RS19860	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C6569_RS19865	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C6569_RS19880	COG0564	pseudouridine synthase activity
C6569_RS19885	COG0552	protein localization to endoplasmic reticulum
C6569_RS19920	COG1136	(ABC) transporter
C6569_RS19920	COG0577	efflux transmembrane transporter activity
C6569_RS19925	COG5001	Diguanylate cyclase
C6569_RS19925	COG3300	MHYT domain
C6569_RS19930	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C6569_RS19935	COG0494	nUDIX hydrolase
C6569_RS19950	COG0183	Belongs to the thiolase family
C6569_RS19955	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
C6569_RS19970	COG0405	Gamma-glutamyltransferase
C6569_RS19980	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C6569_RS20010	COG0625	glutathione transferase activity
C6569_RS20015	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C6569_RS20020	COG4133	protoheme IX ABC transporter activity
C6569_RS20025	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C6569_RS20055	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C6569_RS20060	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C6569_RS20070	COG2186	Transcriptional regulator
C6569_RS20085	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C6569_RS20090	COG1278	Cold shock
C6569_RS20100	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C6569_RS20105	COG0527	aspartate kinase activity
C6569_RS20110	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
C6569_RS20115	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C6569_RS20120	COG2890	protein-(glutamine-N5) methyltransferase activity
C6569_RS20130	COG0670	Belongs to the BI1 family
C6569_RS20140	COG4181	ATPase activity
C6569_RS20150	COG0667	Aldo Keto reductase
C6569_RS20165	COG0473	3-isopropylmalate dehydrogenase activity
C6569_RS20185	COG0400	carboxylic ester hydrolase activity
C6569_RS20190	COG0346	lactoylglutathione lyase activity
C6569_RS20205	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C6569_RS20210	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C6569_RS20225	COG5487	UPF0391 membrane protein
C6569_RS20230	COG3920	Histidine kinase
C6569_RS20235	COG0628	permease
C6569_RS20250	COG0784	Response regulator, receiver
C6569_RS20280	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C6569_RS20305	COG0784	Response regulator, receiver
C6569_RS20310	COG0784	Response regulator, receiver
C6569_RS20325	COG3842	ATPase activity
C6569_RS20335	COG1176	ABC-type spermidine putrescine transport system, permease component I
C6569_RS20380	COG1079	Belongs to the binding-protein-dependent transport system permease family
C6569_RS20390	COG0410	ABC transporter
C6569_RS20395	COG1137	ATPase activity
C6569_RS20440	COG0577	efflux transmembrane transporter activity
C6569_RS20440	COG1136	(ABC) transporter
C6569_RS20450	COG0848	biopolymer transport protein
C6569_RS20490	COG3920	Histidine kinase
C6569_RS20525	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C6569_RS20535	COG0398	Pfam SNARE associated Golgi protein
C6569_RS20555	COG0058	SHG alpha-glucan phosphorylase activity
C6569_RS20565	COG0297	glycogen (starch) synthase activity
C6569_RS20585	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C6569_RS20610	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C6569_RS20625	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C6569_RS20630	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C6569_RS20640	COG0779	Required for maturation of 30S ribosomal subunits
C6569_RS20655	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C6569_RS20680	COG0137	argininosuccinate synthase activity
C6569_RS20690	COG0165	Argininosuccinate lyase
C6569_RS20695	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C6569_RS20705	COG2154	pterin-4-alpha-carbinolamine dehydratase
C6569_RS20740	COG0840	transmembrane signaling receptor activity
C6569_RS20745	COG0251	oxidation-reduction process
C6569_RS20760	COG1028	Short-chain dehydrogenase reductase Sdr
C6569_RS20765	COG0735	belongs to the Fur family
C6569_RS20770	COG0840	transmembrane signaling receptor activity
C6569_RS20775	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C6569_RS20780	COG4221	oxidoreductase activity
C6569_RS20785	COG3118	belongs to the thioredoxin family
C6569_RS20790	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C6569_RS20795	COG1024	Enoyl-CoA hydratase
C6569_RS20800	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C6569_RS20820	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
C6569_RS20825	COG1509	lysine 2,3-aminomutase activity
C6569_RS20830	COG2824	Alkylphosphonate utilization operon protein PhnA
C6569_RS20840	COG1489	DNA binding
C6569_RS20850	COG4302	ethanolamine ammonia-lyase activity
C6569_RS20855	COG4303	Ethanolamine ammonia lyase large subunit
C6569_RS20860	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C6569_RS20865	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C6569_RS20885	COG1172	Belongs to the binding-protein-dependent transport system permease family
C6569_RS20900	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C6569_RS20905	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
C6569_RS20930	COG3264	Mechanosensitive ion channel
C6569_RS20930	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
C6569_RS20950	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C6569_RS20960	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C6569_RS20980	COG0287	Prephenate dehydrogenase
C6569_RS20985	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C6569_RS20995	COG0251	oxidation-reduction process
C6569_RS21000	COG0066	3-isopropylmalate dehydratase activity
C6569_RS21010	COG1309	transcriptional regulator
C6569_RS21020	COG1473	amidohydrolase
C6569_RS21025	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C6569_RS21040	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C6569_RS21045	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C6569_RS21050	COG4536	flavin adenine dinucleotide binding
C6569_RS21055	COG1803	Methylglyoxal synthase
C6569_RS21075	COG1473	amidohydrolase
C6569_RS21110	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C6569_RS21115	COG1040	competence protein
C6569_RS21120	COG3118	belongs to the thioredoxin family
C6569_RS21125	COG3135	benzoate transporter
C6569_RS21130	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C6569_RS21135	COG1136	(ABC) transporter
C6569_RS21150	COG3181	Tripartite tricarboxylate transporter family receptor
C6569_RS21170	COG2326	polyphosphate kinase activity
C6569_RS21180	COG1573	uracil-dna glycosylase
C6569_RS21195	COG0840	transmembrane signaling receptor activity
C6569_RS21200	COG0556	nucleotide-excision repair
C6569_RS21230	COG0335	large ribosomal subunit rRNA binding
C6569_RS21235	COG0336	Belongs to the RNA methyltransferase TrmD family
C6569_RS21240	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C6569_RS21245	COG0228	four-way junction DNA binding
C6569_RS21250	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C6569_RS21280	COG0142	geranyltranstransferase activity
C6569_RS21295	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C6569_RS21305	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C6569_RS21315	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C6569_RS21320	COG4948	Mandelate Racemase Muconate Lactonizing
C6569_RS21325	COG1217	gtp-binding protein TYPA
C6569_RS21340	COG0784	Response regulator, receiver
C6569_RS21345	COG2199	diguanylate cyclase activity
C6569_RS21345	COG2200	EAL domain
C6569_RS21345	COG2202	Pas domain
C6569_RS21350	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C6569_RS21360	COG1917	Cupin 2, conserved barrel domain protein
C6569_RS21360	COG1396	sequence-specific DNA binding
C6569_RS21365	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C6569_RS21370	COG3300	MHYT domain
C6569_RS21370	COG5001	Diguanylate cyclase
C6569_RS21375	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C6569_RS21415	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C6569_RS21425	COG1764	response to oxidative stress
C6569_RS21430	COG1846	Transcriptional regulator
C6569_RS21440	COG0247	lactate metabolic process
C6569_RS21445	COG0277	FAD linked oxidase domain protein
C6569_RS21450	COG0277	FAD linked oxidase domain protein
C6569_RS21455	COG0583	DNA-binding transcription factor activity
C6569_RS21460	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
C6569_RS21465	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C6569_RS21490	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
C6569_RS21530	COG0494	nUDIX hydrolase
C6569_RS21535	COG0166	Belongs to the GPI family
C6569_RS21550	COG0765	amino acid transport
C6569_RS21555	COG0765	amino acid transport
C6569_RS21585	COG3734	2-keto-3-deoxy-galactonokinase
C6569_RS21590	COG2759	Belongs to the formate--tetrahydrofolate ligase family