locus-tag	class	description
L21SP3_RS00025	COG0328	RNA-DNA hybrid ribonuclease activity
L21SP3_RS00030	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
L21SP3_RS00035	COG3250	beta-galactosidase activity
L21SP3_RS00050	COG2226	methyltransferase
L21SP3_RS00055	COG3119	arylsulfatase activity
L21SP3_RS00065	COG2885	chlorophyll binding
L21SP3_RS00095	COG1472	Belongs to the glycosyl hydrolase 3 family
L21SP3_RS00105	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
L21SP3_RS00110	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
L21SP3_RS00120	COG0237	dephospho-CoA kinase activity
L21SP3_RS00140	COG2304	oxidoreductase activity
L21SP3_RS00150	COG0728	peptidoglycan biosynthetic process
L21SP3_RS00190	COG1131	(ABC) transporter
L21SP3_RS00200	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
L21SP3_RS00205	COG1187	pseudouridine synthase activity
L21SP3_RS00210	COG1262	PFAM Formylglycine-generating sulfatase enzyme
L21SP3_RS00240	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
L21SP3_RS00240	COG0646	methionine synthase
L21SP3_RS00245	COG1410	methionine synthase
L21SP3_RS00245	COG0646	methionine synthase
L21SP3_RS00250	COG3119	arylsulfatase activity
L21SP3_RS00255	COG0473	3-isopropylmalate dehydrogenase activity
L21SP3_RS00260	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
L21SP3_RS00280	COG1196	nuclear chromosome segregation
L21SP3_RS00285	COG0612	Peptidase, M16
L21SP3_RS00290	COG0612	Peptidase, M16
L21SP3_RS00295	COG0535	radical SAM domain protein
L21SP3_RS00305	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
L21SP3_RS00310	COG0812	UDP-N-acetylmuramate dehydrogenase activity
L21SP3_RS00325	COG1609	Transcriptional regulator
L21SP3_RS00325	COG2207	Transcriptional regulator
L21SP3_RS00340	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
L21SP3_RS00345	COG0205	6-phosphofructokinase activity
L21SP3_RS00355	COG2239	Acts as a magnesium transporter
L21SP3_RS00360	COG1082	Xylose isomerase domain protein TIM barrel
L21SP3_RS00405	COG0124	histidyl-tRNA synthetase
L21SP3_RS00425	COG1192	Involved in chromosome partitioning
L21SP3_RS00430	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
L21SP3_RS00435	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
L21SP3_RS00440	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
L21SP3_RS00450	COG0505	Belongs to the CarA family
L21SP3_RS00455	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
L21SP3_RS00460	COG0438	transferase activity, transferring glycosyl groups
L21SP3_RS00475	COG2826	transposase and inactivated derivatives, IS30 family
L21SP3_RS00480	COG0594	ribonuclease P activity
L21SP3_RS00485	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
L21SP3_RS00485	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L21SP3_RS00485	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L21SP3_RS00525	COG0489	protein tyrosine kinase activity
L21SP3_RS00535	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
L21SP3_RS00545	COG0826	peptidase U32
L21SP3_RS00560	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
L21SP3_RS00570	COG1968	undecaprenyl-diphosphatase activity
L21SP3_RS00580	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
L21SP3_RS00595	COG0071	Belongs to the small heat shock protein (HSP20) family
L21SP3_RS00605	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
L21SP3_RS00615	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
L21SP3_RS00620	COG0151	Belongs to the GarS family
L21SP3_RS00630	COG0463	Glycosyl transferase, family 2
L21SP3_RS00645	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
L21SP3_RS00650	COG0540	Belongs to the ATCase OTCase family
L21SP3_RS00655	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
L21SP3_RS00660	COG0571	ribonuclease III activity
L21SP3_RS00665	COG1902	pentaerythritol trinitrate reductase activity
L21SP3_RS00675	COG4585	Histidine kinase
L21SP3_RS00705	COG0745	RESPONSE REGULATOR receiver
L21SP3_RS00710	COG0528	UMP kinase activity
L21SP3_RS00715	COG0233	cytoplasmic translational termination
L21SP3_RS00725	COG1295	ribonuclease BN
L21SP3_RS00730	COG0772	Belongs to the SEDS family
L21SP3_RS00735	COG2155	Conserved Protein
L21SP3_RS00740	COG2207	Transcriptional regulator
L21SP3_RS00745	COG2165	general secretion pathway protein
L21SP3_RS00765	COG3250	beta-galactosidase activity
L21SP3_RS00770	COG2207	Transcriptional regulator
L21SP3_RS00770	COG1609	Transcriptional regulator
L21SP3_RS00795	COG3119	arylsulfatase activity
L21SP3_RS00815	COG3537	Alpha-1,2-mannosidase
L21SP3_RS00855	COG1872	DUF167
L21SP3_RS00865	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
L21SP3_RS00880	COG3119	arylsulfatase activity
L21SP3_RS00895	COG1214	PFAM Peptidase M22, glycoprotease
L21SP3_RS00900	COG4796	Type ii and iii secretion system protein
L21SP3_RS00915	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
L21SP3_RS00920	COG0750	zinc metalloprotease
L21SP3_RS00925	COG1216	Glycosyl transferase, family 2
L21SP3_RS00930	COG1215	transferase activity, transferring glycosyl groups
L21SP3_RS00935	COG1216	Glycosyl transferase, family 2
L21SP3_RS00940	COG1215	transferase activity, transferring glycosyl groups
L21SP3_RS00945	COG1215	transferase activity, transferring glycosyl groups
L21SP3_RS00970	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
L21SP3_RS00975	COG0131	Imidazoleglycerol-phosphate dehydratase
L21SP3_RS00980	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
L21SP3_RS00985	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
L21SP3_RS00990	COG0333	Belongs to the bacterial ribosomal protein bL32 family
L21SP3_RS00995	COG0416	fatty acid biosynthetic process
L21SP3_RS01000	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L21SP3_RS01005	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
L21SP3_RS01010	COG1028	Short-chain dehydrogenase reductase Sdr
L21SP3_RS01015	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L21SP3_RS01020	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
L21SP3_RS01025	COG0159	tryptophan synthase activity
L21SP3_RS01035	COG0135	phosphoribosylanthranilate isomerase activity
L21SP3_RS01040	COG0134	indole-3-glycerol-phosphate synthase activity
L21SP3_RS01045	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
L21SP3_RS01050	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
L21SP3_RS01050	COG0512	Glutamine amidotransferase of anthranilate synthase
L21SP3_RS01065	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L21SP3_RS01090	COG0232	Belongs to the dGTPase family. Type 2 subfamily
L21SP3_RS01095	COG0175	sulfate reduction
L21SP3_RS01105	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
L21SP3_RS01115	COG2895	sulfate adenylyltransferase (ATP) activity
L21SP3_RS01125	COG2361	Protein of unknown function DUF86
L21SP3_RS01135	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L21SP3_RS01140	COG4106	trans-aconitate 2-methyltransferase activity
L21SP3_RS01155	COG2873	o-acetylhomoserine
L21SP3_RS01165	COG0330	HflC and HflK could
L21SP3_RS01190	COG1238	metal cluster binding
L21SP3_RS01205	COG1069	ribulokinase activity
L21SP3_RS01240	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
L21SP3_RS01240	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
L21SP3_RS01245	COG0825	malonyl-CoA metabolic process
L21SP3_RS01250	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
L21SP3_RS01265	COG0534	Mate efflux family protein
L21SP3_RS01275	COG1519	Transferase
L21SP3_RS01280	COG0641	radical SAM
L21SP3_RS01290	COG0436	Aminotransferase
L21SP3_RS01310	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
L21SP3_RS01315	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
L21SP3_RS01320	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
L21SP3_RS01335	COG3119	arylsulfatase activity
L21SP3_RS01340	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L21SP3_RS01345	COG0037	tRNA processing
L21SP3_RS01355	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L21SP3_RS01355	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L21SP3_RS01360	COG1774	PSP1 C-terminal conserved region
L21SP3_RS01365	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
L21SP3_RS01370	COG0423	glycine-tRNA ligase activity
L21SP3_RS01375	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
L21SP3_RS01380	COG0227	Belongs to the bacterial ribosomal protein bL28 family
L21SP3_RS01415	COG1122	ATPase activity
L21SP3_RS01460	COG3250	beta-galactosidase activity
L21SP3_RS01485	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
L21SP3_RS01500	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
L21SP3_RS01515	COG3119	arylsulfatase activity
L21SP3_RS01520	COG0318	PFAM AMP-dependent synthetase and ligase
L21SP3_RS01555	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
L21SP3_RS01560	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
L21SP3_RS01570	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
L21SP3_RS01575	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
L21SP3_RS01585	COG0635	Involved in the biosynthesis of porphyrin-containing compound
L21SP3_RS01590	COG3119	arylsulfatase activity
L21SP3_RS01605	COG3119	arylsulfatase activity
L21SP3_RS01610	COG3119	arylsulfatase activity
L21SP3_RS01620	COG3119	arylsulfatase activity
L21SP3_RS01635	COG0800	Aldolase
L21SP3_RS01640	COG2207	Transcriptional regulator
L21SP3_RS01640	COG1609	Transcriptional regulator
L21SP3_RS01645	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
L21SP3_RS01690	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
L21SP3_RS01690	COG3264	Mechanosensitive ion channel
L21SP3_RS01700	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L21SP3_RS01705	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
L21SP3_RS01705	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
L21SP3_RS01740	COG3250	beta-galactosidase activity
L21SP3_RS01755	COG3901	Regulator of nitric oxide reductase transcription
L21SP3_RS01755	COG0348	domain, Protein
L21SP3_RS01790	COG0335	large ribosomal subunit rRNA binding
L21SP3_RS01795	COG0336	Belongs to the RNA methyltransferase TrmD family
L21SP3_RS01800	COG0228	four-way junction DNA binding
L21SP3_RS01810	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
L21SP3_RS01815	COG0442	prolyl-tRNA aminoacylation
L21SP3_RS01820	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
L21SP3_RS01830	COG0802	atpase or kinase
L21SP3_RS01835	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
L21SP3_RS01845	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
L21SP3_RS01850	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
L21SP3_RS01855	COG1136	(ABC) transporter
L21SP3_RS01860	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
L21SP3_RS01885	COG3250	beta-galactosidase activity
L21SP3_RS01895	COG2890	protein-(glutamine-N5) methyltransferase activity
L21SP3_RS01920	COG2814	Major facilitator Superfamily
L21SP3_RS01920	COG0477	Major facilitator Superfamily
L21SP3_RS01940	COG3119	arylsulfatase activity
L21SP3_RS01950	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
L21SP3_RS01955	COG0459	protein refolding
L21SP3_RS01985	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
L21SP3_RS01995	COG1136	(ABC) transporter
L21SP3_RS02000	COG0706	membrane insertase activity
L21SP3_RS02015	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
L21SP3_RS02020	COG0316	Belongs to the HesB IscA family
L21SP3_RS02020	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
L21SP3_RS02030	COG1663	tetraacyldisaccharide 4'-kinase activity
L21SP3_RS02035	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
L21SP3_RS02035	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
L21SP3_RS02045	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
L21SP3_RS02050	COG1127	ABC transporter
L21SP3_RS02065	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
L21SP3_RS02070	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
L21SP3_RS02075	COG0193	aminoacyl-tRNA hydrolase activity
L21SP3_RS02080	COG0360	Binds together with S18 to 16S ribosomal RNA
L21SP3_RS02085	COG0629	single-stranded DNA binding
L21SP3_RS02090	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
L21SP3_RS02095	COG0359	binds to the 23S rRNA
L21SP3_RS02100	COG0305	Participates in initiation and elongation during chromosome replication
L21SP3_RS02130	COG0107	imidazoleglycerol-phosphate synthase activity
L21SP3_RS02140	COG0667	Aldo Keto reductase
L21SP3_RS02150	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
L21SP3_RS02150	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
L21SP3_RS02150	COG1013	pyruvate-flavodoxin oxidoreductase activity
L21SP3_RS02150	COG0674	pyruvate-flavodoxin oxidoreductase activity
L21SP3_RS02165	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
L21SP3_RS02175	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L21SP3_RS02180	COG1028	Short-chain dehydrogenase reductase Sdr
L21SP3_RS02185	COG1414	Transcriptional regulator
L21SP3_RS02210	COG4145	pantothenate transmembrane transporter activity
L21SP3_RS02215	COG4145	pantothenate transmembrane transporter activity
L21SP3_RS02220	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
L21SP3_RS02225	COG0254	rRNA binding
L21SP3_RS02235	COG1450	Type ii and iii secretion system protein
L21SP3_RS02245	COG2826	transposase and inactivated derivatives, IS30 family
L21SP3_RS02280	COG3250	beta-galactosidase activity
L21SP3_RS02290	COG0552	protein localization to endoplasmic reticulum
L21SP3_RS02360	COG1269	ATP hydrolysis coupled proton transport
L21SP3_RS02385	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
L21SP3_RS02390	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
L21SP3_RS02395	COG1394	ATPase activity, coupled to movement of substances
L21SP3_RS02400	COG1262	PFAM Formylglycine-generating sulfatase enzyme
L21SP3_RS02405	COG2877	3-deoxy-8-phosphooctulonate synthase activity
L21SP3_RS02410	COG0731	radical SAM domain protein
L21SP3_RS02410	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
L21SP3_RS02415	COG1959	2 iron, 2 sulfur cluster binding
L21SP3_RS02425	COG1045	serine acetyltransferase
L21SP3_RS02440	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
L21SP3_RS02460	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
L21SP3_RS02490	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
L21SP3_RS02500	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
L21SP3_RS02510	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L21SP3_RS02520	COG1012	belongs to the aldehyde dehydrogenase family
L21SP3_RS02520	COG1454	alcohol dehydrogenase
L21SP3_RS02525	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L21SP3_RS02550	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
L21SP3_RS02555	COG0544	peptidyl-prolyl cis-trans isomerase activity
L21SP3_RS02565	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
L21SP3_RS02580	COG0668	transmembrane transport
L21SP3_RS02590	COG0047	phosphoribosylformylglycinamidine synthase activity
L21SP3_RS02595	COG0343	queuine tRNA-ribosyltransferase activity
L21SP3_RS02600	COG2385	sporulation resulting in formation of a cellular spore
L21SP3_RS02605	COG0202	RNA polymerase activity
L21SP3_RS02620	COG0330	HflC and HflK could
L21SP3_RS02625	COG0330	HflC and HflK could
L21SP3_RS02635	COG1131	(ABC) transporter
L21SP3_RS02650	COG0210	DNA helicase
L21SP3_RS02670	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
L21SP3_RS02675	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
L21SP3_RS02695	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
L21SP3_RS02705	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
L21SP3_RS02705	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
L21SP3_RS02715	COG1595	DNA-templated transcription, initiation
L21SP3_RS02725	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
L21SP3_RS02730	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
L21SP3_RS02735	COG0287	Prephenate dehydrogenase
L21SP3_RS02745	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
L21SP3_RS02760	COG0126	phosphoglycerate kinase activity
L21SP3_RS02770	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
L21SP3_RS02780	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
L21SP3_RS02785	COG0148	phosphopyruvate hydratase activity
L21SP3_RS02795	COG1691	(AIR) carboxylase
L21SP3_RS02800	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
L21SP3_RS02800	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
L21SP3_RS02845	COG1028	Short-chain dehydrogenase reductase Sdr
L21SP3_RS02855	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L21SP3_RS02860	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
L21SP3_RS02865	COG1904	glucuronate isomerase
L21SP3_RS02885	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
L21SP3_RS02890	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
L21SP3_RS02905	COG4251	negative regulation of phosphorylation
L21SP3_RS02920	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
L21SP3_RS02935	COG0602	queuosine metabolic process
L21SP3_RS02945	COG0330	HflC and HflK could
L21SP3_RS02980	COG0698	ribose 5-phosphate isomerase
L21SP3_RS02985	COG0504	CTP synthase activity
L21SP3_RS02990	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
L21SP3_RS02995	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
L21SP3_RS03000	COG0481	GTPase activity
L21SP3_RS03005	COG0724	RNA recognition motif
L21SP3_RS03010	COG0019	diaminopimelate decarboxylase activity
L21SP3_RS03015	COG1404	Belongs to the peptidase S8 family
L21SP3_RS03030	COG0372	Belongs to the citrate synthase family
L21SP3_RS03040	COG1160	GTP binding
L21SP3_RS03055	COG1722	exodeoxyribonuclease VII activity
L21SP3_RS03060	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
L21SP3_RS03065	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
L21SP3_RS03080	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
L21SP3_RS03085	COG0321	lipoyl(octanoyl) transferase activity
L21SP3_RS03095	COG1482	cell wall glycoprotein biosynthetic process
L21SP3_RS03105	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
L21SP3_RS03110	COG0205	6-phosphofructokinase activity
L21SP3_RS03120	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
L21SP3_RS03130	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
L21SP3_RS03145	COG1940	carbohydrate kinase activity
L21SP3_RS03150	COG2165	general secretion pathway protein
L21SP3_RS03175	COG1595	DNA-templated transcription, initiation
L21SP3_RS03185	COG0402	S-adenosylhomocysteine deaminase activity
L21SP3_RS03220	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
L21SP3_RS03230	COG0084	hydrolase, TatD family'
L21SP3_RS03235	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
L21SP3_RS03250	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
L21SP3_RS03260	COG0432	Pfam Uncharacterised protein family UPF0047
L21SP3_RS03270	COG2273	Hydrolase Family 16
L21SP3_RS03280	COG0590	tRNA wobble adenosine to inosine editing
L21SP3_RS03295	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L21SP3_RS03310	COG1940	carbohydrate kinase activity
L21SP3_RS03335	COG0302	gtp cyclohydrolase
L21SP3_RS03345	COG1088	dTDP-glucose 4,6-dehydratase activity
L21SP3_RS03350	COG1027	Aspartate ammonia-lyase
L21SP3_RS03365	COG2165	general secretion pathway protein
L21SP3_RS03390	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
L21SP3_RS03395	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L21SP3_RS03405	COG0205	6-phosphofructokinase activity
L21SP3_RS03410	COG0857	belongs to the CobB CobQ family
L21SP3_RS03410	COG0280	phosphate acetyltransferase
L21SP3_RS03415	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
L21SP3_RS03465	COG0194	GDP metabolic process
L21SP3_RS03480	COG0463	Glycosyl transferase, family 2
L21SP3_RS03505	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
L21SP3_RS03525	COG1385	rRNA (uridine-N3-)-methyltransferase activity
L21SP3_RS03530	COG0708	Exodeoxyribonuclease III
L21SP3_RS03540	COG1309	transcriptional regulator
L21SP3_RS03545	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
L21SP3_RS03555	COG1573	uracil-dna glycosylase
L21SP3_RS03560	COG1132	(ABC) transporter
L21SP3_RS03570	COG0646	methionine synthase
L21SP3_RS03570	COG1410	methionine synthase
L21SP3_RS03575	COG0508	dehydrogenase complex catalyzes the overall conversion of
L21SP3_RS03585	COG0673	inositol 2-dehydrogenase activity
L21SP3_RS03610	COG4948	Mandelate Racemase Muconate Lactonizing
L21SP3_RS03630	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L21SP3_RS03640	COG4968	Prepilin-type N-terminal cleavage methylation domain
L21SP3_RS03645	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
L21SP3_RS03660	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L21SP3_RS03710	COG0572	uridine kinase
L21SP3_RS03725	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
L21SP3_RS03730	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
L21SP3_RS03735	COG0438	transferase activity, transferring glycosyl groups
L21SP3_RS03745	COG0438	transferase activity, transferring glycosyl groups
L21SP3_RS03755	COG0745	RESPONSE REGULATOR receiver
L21SP3_RS03785	COG2801	Transposase and inactivated derivatives
L21SP3_RS03795	COG3940	Belongs to the glycosyl hydrolase 43 family
L21SP3_RS03805	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
L21SP3_RS03820	COG0444	Belongs to the ABC transporter superfamily
L21SP3_RS03825	COG4608	Belongs to the ABC transporter superfamily
L21SP3_RS03835	COG3119	arylsulfatase activity
L21SP3_RS03850	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
L21SP3_RS03850	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
L21SP3_RS03855	COG1595	DNA-templated transcription, initiation
L21SP3_RS03865	COG1595	DNA-templated transcription, initiation
L21SP3_RS03870	COG3534	alpha-L-arabinofuranosidase
L21SP3_RS03885	COG1609	Transcriptional regulator
L21SP3_RS03885	COG2207	Transcriptional regulator
L21SP3_RS03890	COG1070	Carbohydrate kinase
L21SP3_RS03895	COG2115	Belongs to the xylose isomerase family
L21SP3_RS03905	COG3401	FG-GAP repeat protein
L21SP3_RS03910	COG3401	FG-GAP repeat protein
L21SP3_RS03920	COG2160	L-arabinose isomerase activity
L21SP3_RS03925	COG2207	Transcriptional regulator
L21SP3_RS03925	COG1609	Transcriptional regulator
L21SP3_RS03950	COG4656	Part of a membrane complex involved in electron transport
L21SP3_RS03955	COG4658	electron transport chain
L21SP3_RS03960	COG4659	FMN binding
L21SP3_RS03965	COG4660	Part of a membrane complex involved in electron transport
L21SP3_RS03970	COG4657	Part of a membrane complex involved in electron transport
L21SP3_RS03975	COG2878	Part of a membrane complex involved in electron transport
L21SP3_RS03980	COG0657	acetylesterase activity
L21SP3_RS03980	COG2755	lipolytic protein G-D-S-L family
L21SP3_RS03995	COG0297	glycogen (starch) synthase activity
L21SP3_RS04010	COG0180	Tryptophanyl-tRNA synthetase
L21SP3_RS04015	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
L21SP3_RS04020	COG1253	flavin adenine dinucleotide binding
L21SP3_RS04025	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
L21SP3_RS04030	COG2183	response to ionizing radiation
L21SP3_RS04030	COG0539	negative regulation of cytoplasmic translation
L21SP3_RS04070	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L21SP3_RS04075	COG3119	arylsulfatase activity
L21SP3_RS04105	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
L21SP3_RS04125	COG0211	Belongs to the bacterial ribosomal protein bL27 family
L21SP3_RS04130	COG0268	Binds directly to 16S ribosomal RNA
L21SP3_RS04135	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
L21SP3_RS04140	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
L21SP3_RS04155	COG3481	metal-dependent phosphohydrolase, HD sub domain
L21SP3_RS04165	COG3250	beta-galactosidase activity
L21SP3_RS04170	COG3250	beta-galactosidase activity
L21SP3_RS04185	COG0483	inositol monophosphate 1-phosphatase activity
L21SP3_RS04195	COG0617	tRNA 3'-terminal CCA addition
L21SP3_RS04205	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
L21SP3_RS04210	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L21SP3_RS04215	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
L21SP3_RS04235	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
L21SP3_RS04240	COG1185	polyribonucleotide nucleotidyltransferase activity
L21SP3_RS04255	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
L21SP3_RS04265	COG0564	pseudouridine synthase activity
L21SP3_RS04295	COG0501	Belongs to the peptidase M48B family
L21SP3_RS04305	COG1704	LemA family
L21SP3_RS04325	COG2165	general secretion pathway protein
L21SP3_RS04340	COG0577	efflux transmembrane transporter activity
L21SP3_RS04340	COG1136	(ABC) transporter
L21SP3_RS04345	COG1136	(ABC) transporter
L21SP3_RS04360	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
L21SP3_RS04385	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
L21SP3_RS04400	COG0784	Response regulator, receiver
L21SP3_RS04410	COG0727	PFAM Uncharacterised protein family (UPF0153)
L21SP3_RS04425	COG0356	it plays a direct role in the translocation of protons across the membrane
L21SP3_RS04430	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
L21SP3_RS04435	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
L21SP3_RS04440	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
L21SP3_RS04445	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
L21SP3_RS04455	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
L21SP3_RS04460	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
L21SP3_RS04465	COG0355	proton-transporting ATP synthase activity, rotational mechanism
L21SP3_RS04535	COG3119	arylsulfatase activity
L21SP3_RS04550	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L21SP3_RS04575	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
L21SP3_RS04630	COG0006	proline dipeptidase activity
L21SP3_RS04635	COG0784	Response regulator, receiver
L21SP3_RS04640	COG1450	Type ii and iii secretion system protein
L21SP3_RS04685	COG1459	type II secretion system
L21SP3_RS04715	COG2255	four-way junction helicase activity
L21SP3_RS04735	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L21SP3_RS04740	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
L21SP3_RS04745	COG1086	Polysaccharide biosynthesis protein
L21SP3_RS04755	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
L21SP3_RS04760	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
L21SP3_RS04815	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L21SP3_RS04820	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
L21SP3_RS04840	COG1216	Glycosyl transferase, family 2
L21SP3_RS04900	COG0052	Belongs to the universal ribosomal protein uS2 family
L21SP3_RS04905	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
L21SP3_RS04930	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
L21SP3_RS04935	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L21SP3_RS04940	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
L21SP3_RS05010	COG0693	protein deglycase activity
L21SP3_RS05025	COG2172	sigma factor antagonist activity
L21SP3_RS05030	COG0133	tryptophan synthase activity
L21SP3_RS05055	COG0166	Belongs to the GPI family
L21SP3_RS05075	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
L21SP3_RS05095	COG2963	transposase activity
L21SP3_RS05100	COG2801	Transposase and inactivated derivatives
L21SP3_RS05120	COG1917	Cupin 2, conserved barrel domain protein
L21SP3_RS05120	COG4977	sequence-specific DNA binding
L21SP3_RS05135	COG0205	6-phosphofructokinase activity
L21SP3_RS05145	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
L21SP3_RS05150	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
L21SP3_RS05170	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
L21SP3_RS05175	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
L21SP3_RS05180	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
L21SP3_RS05190	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
L21SP3_RS05195	COG2801	Transposase and inactivated derivatives
L21SP3_RS05215	COG0805	protein transport
L21SP3_RS05220	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
L21SP3_RS05230	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
L21SP3_RS05240	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
L21SP3_RS05245	COG2165	general secretion pathway protein
L21SP3_RS05260	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
L21SP3_RS05270	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L21SP3_RS05270	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L21SP3_RS05275	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
L21SP3_RS05280	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
L21SP3_RS05320	COG0489	protein tyrosine kinase activity
L21SP3_RS05325	COG1702	phosphate starvation-inducible protein PhoH
L21SP3_RS05355	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
L21SP3_RS05365	COG3387	PFAM Glycoside hydrolase 15-related
L21SP3_RS05370	COG0438	transferase activity, transferring glycosyl groups
L21SP3_RS05385	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
L21SP3_RS05385	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
L21SP3_RS05390	COG0129	dihydroxy-acid dehydratase activity
L21SP3_RS05405	COG2205	protein histidine kinase activity
L21SP3_RS05405	COG0784	Response regulator, receiver
L21SP3_RS05405	COG2198	Histidine kinase
L21SP3_RS05440	COG2113	Glycine betaine
L21SP3_RS05445	COG4176	ABC-type proline glycine betaine transport system permease component
L21SP3_RS05455	COG1621	beta-fructofuranosidase activity
L21SP3_RS05475	COG2165	general secretion pathway protein
L21SP3_RS05480	COG1560	Kdo2-lipid A biosynthetic process
L21SP3_RS05485	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
L21SP3_RS05495	COG0438	transferase activity, transferring glycosyl groups
L21SP3_RS05505	COG0438	transferase activity, transferring glycosyl groups
L21SP3_RS05575	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
L21SP3_RS05585	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
L21SP3_RS05590	COG0440	acetolactate synthase activity
L21SP3_RS05595	COG0028	Belongs to the TPP enzyme family
L21SP3_RS05600	COG1830	Aldolase
L21SP3_RS05605	COG0655	NAD(P)H dehydrogenase (quinone) activity
L21SP3_RS05620	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
L21SP3_RS05650	COG2022	thiamine diphosphate biosynthetic process
L21SP3_RS05660	COG1959	2 iron, 2 sulfur cluster binding
L21SP3_RS05685	COG0023	Translation Initiation Factor
L21SP3_RS05705	COG0674	pyruvate-flavodoxin oxidoreductase activity
L21SP3_RS05705	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
L21SP3_RS05735	COG2078	PFAM AMMECR1 domain protein
L21SP3_RS05780	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
L21SP3_RS05800	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
L21SP3_RS05810	COG1418	mRNA catabolic process
L21SP3_RS05820	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
L21SP3_RS05825	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
L21SP3_RS05830	COG0291	Belongs to the bacterial ribosomal protein bL35 family
L21SP3_RS05835	COG2814	Major facilitator Superfamily
L21SP3_RS05840	COG0575	Belongs to the CDS family
L21SP3_RS05845	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
L21SP3_RS05855	COG0667	Aldo Keto reductase
L21SP3_RS05885	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
L21SP3_RS05910	COG3119	arylsulfatase activity
L21SP3_RS05925	COG0556	nucleotide-excision repair
L21SP3_RS05965	COG1459	type II secretion system
L21SP3_RS06000	COG4977	sequence-specific DNA binding
L21SP3_RS06015	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L21SP3_RS06020	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
L21SP3_RS06045	COG0235	Class ii aldolase
L21SP3_RS06050	COG4806	L-rhamnose isomerase
L21SP3_RS06055	COG3119	arylsulfatase activity
L21SP3_RS06060	COG1472	Belongs to the glycosyl hydrolase 3 family
L21SP3_RS06070	COG0537	adenosine 5'-monophosphoramidase activity
L21SP3_RS06075	COG0203	ribosomal protein L17
L21SP3_RS06080	COG0202	RNA polymerase activity
L21SP3_RS06085	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
L21SP3_RS06090	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
L21SP3_RS06095	COG0257	Belongs to the bacterial ribosomal protein bL36 family
L21SP3_RS06100	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
L21SP3_RS06105	COG0024	Methionine aminopeptidase
L21SP3_RS06110	COG0563	adenylate kinase activity
L21SP3_RS06115	COG0201	protein transport
L21SP3_RS06120	COG0200	Binds to the 23S rRNA
L21SP3_RS06130	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
L21SP3_RS06135	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
L21SP3_RS06140	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
L21SP3_RS06145	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
L21SP3_RS06155	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
L21SP3_RS06160	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
L21SP3_RS06170	COG0255	Belongs to the universal ribosomal protein uL29 family
L21SP3_RS06175	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
L21SP3_RS06185	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
L21SP3_RS06190	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
L21SP3_RS06195	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
L21SP3_RS06200	COG0089	rRNA binding
L21SP3_RS06205	COG0088	Forms part of the polypeptide exit tunnel
L21SP3_RS06215	COG0051	transcription antitermination factor activity, RNA binding
L21SP3_RS06305	COG1459	type II secretion system
L21SP3_RS06310	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
L21SP3_RS06320	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
L21SP3_RS06325	COG1058	Belongs to the CinA family
L21SP3_RS06325	COG1546	Belongs to the CinA family
L21SP3_RS06345	COG0511	ligase activity, forming carbon-carbon bonds
L21SP3_RS06365	COG0436	Aminotransferase
L21SP3_RS06390	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
L21SP3_RS06410	COG0569	domain protein
L21SP3_RS06420	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
L21SP3_RS06420	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
L21SP3_RS06435	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L21SP3_RS06470	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
L21SP3_RS06515	COG2205	protein histidine kinase activity
L21SP3_RS06515	COG0784	Response regulator, receiver
L21SP3_RS06525	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
L21SP3_RS06525	COG0758	DNA mediated transformation
L21SP3_RS06530	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
L21SP3_RS06535	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
L21SP3_RS06545	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
L21SP3_RS06550	COG0517	IMP dehydrogenase activity
L21SP3_RS06550	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
L21SP3_RS06555	COG1530	ribonuclease E activity
L21SP3_RS06565	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
L21SP3_RS06575	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
L21SP3_RS06575	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
L21SP3_RS06600	COG3119	arylsulfatase activity
L21SP3_RS06625	COG0740	serine-type endopeptidase activity
L21SP3_RS06630	COG0740	serine-type endopeptidase activity
L21SP3_RS06635	COG0543	2 iron, 2 sulfur cluster binding
L21SP3_RS06640	COG0493	'glutamate synthase
L21SP3_RS06650	COG0443	Heat shock 70 kDa protein
L21SP3_RS06680	COG0714	Associated with various cellular activities
L21SP3_RS06710	COG1199	ATP-dependent helicase activity
L21SP3_RS06715	COG0606	chelatase, subunit chli
L21SP3_RS06720	COG0542	response to heat
L21SP3_RS06740	COG0450	alkyl hydroperoxide reductase
L21SP3_RS06775	COG1652	LysM domain
L21SP3_RS06780	COG0275	rRNA processing
L21SP3_RS06785	COG2001	Belongs to the MraZ family
L21SP3_RS06795	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
L21SP3_RS06800	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
L21SP3_RS06805	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
L21SP3_RS06815	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
L21SP3_RS06830	COG0390	transport system, permease component
L21SP3_RS06845	COG0424	maF-like protein
L21SP3_RS06865	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
L21SP3_RS06870	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
L21SP3_RS06875	COG1480	7TM receptor with intracellular HD hydrolase
L21SP3_RS06880	COG3119	arylsulfatase activity
L21SP3_RS06895	COG0484	heat shock protein binding
L21SP3_RS06900	COG0459	protein refolding
L21SP3_RS06910	COG0459	protein refolding
L21SP3_RS06920	COG0811	peptide transport
L21SP3_RS06940	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
L21SP3_RS06955	COG3119	arylsulfatase activity
L21SP3_RS06960	COG0542	response to heat
L21SP3_RS06990	COG0518	GMP synthase (glutamine-hydrolyzing) activity
L21SP3_RS06990	COG0519	Catalyzes the synthesis of GMP from XMP
L21SP3_RS06995	COG0516	GMP reductase activity
L21SP3_RS06995	COG0517	IMP dehydrogenase activity
L21SP3_RS07060	COG1940	carbohydrate kinase activity
L21SP3_RS07065	COG3119	arylsulfatase activity
L21SP3_RS07075	COG2204	response regulator
L21SP3_RS07080	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
L21SP3_RS07085	COG1971	Probably functions as a manganese efflux pump
L21SP3_RS07095	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
L21SP3_RS07105	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
L21SP3_RS07115	COG0495	leucyl-tRNA aminoacylation
L21SP3_RS07135	COG0138	bifunctional purine biosynthesis protein purh
L21SP3_RS07145	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
L21SP3_RS07160	COG1595	DNA-templated transcription, initiation
L21SP3_RS07175	COG1918	ferrous iron import across plasma membrane
L21SP3_RS07175	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
L21SP3_RS07180	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
L21SP3_RS07180	COG1918	ferrous iron import across plasma membrane
L21SP3_RS07195	COG3385	transposase activity
L21SP3_RS07210	COG1262	PFAM Formylglycine-generating sulfatase enzyme
L21SP3_RS07220	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
L21SP3_RS07275	COG0140	phosphoribosyl-ATP diphosphatase activity
L21SP3_RS07280	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
L21SP3_RS07285	COG3046	protein related to deoxyribodipyrimidine photolyase
L21SP3_RS07295	COG0072	phenylalanine-tRNA ligase activity
L21SP3_RS07305	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
L21SP3_RS07310	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
L21SP3_RS07325	COG0488	(ABC) transporter
L21SP3_RS07330	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
L21SP3_RS07335	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
L21SP3_RS07340	COG2226	methyltransferase
L21SP3_RS07350	COG2165	general secretion pathway protein
L21SP3_RS07355	COG0864	Transcriptional regulator
L21SP3_RS07370	COG2165	general secretion pathway protein
L21SP3_RS07380	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
L21SP3_RS07395	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
L21SP3_RS07400	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
L21SP3_RS07415	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L21SP3_RS07420	COG0601	transmembrane transport
L21SP3_RS07445	COG0110	maltose O-acetyltransferase activity
L21SP3_RS07450	COG2226	methyltransferase
L21SP3_RS07455	COG0484	heat shock protein binding
L21SP3_RS07460	COG0640	Transcriptional regulator
L21SP3_RS07465	COG0823	Involved in the tonB-independent uptake of proteins
L21SP3_RS07475	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L21SP3_RS07480	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L21SP3_RS07495	COG0515	serine threonine protein kinase
L21SP3_RS07495	COG1262	PFAM Formylglycine-generating sulfatase enzyme
L21SP3_RS07500	COG3408	Glycogen debranching enzyme
L21SP3_RS07500	COG3119	arylsulfatase activity
L21SP3_RS07505	COG3119	arylsulfatase activity
L21SP3_RS07515	COG2207	Transcriptional regulator
L21SP3_RS07515	COG1609	Transcriptional regulator
L21SP3_RS07535	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L21SP3_RS07585	COG1051	belongs to the nudix hydrolase family
L21SP3_RS07595	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
L21SP3_RS07610	COG0848	biopolymer transport protein
L21SP3_RS07615	COG0811	peptide transport
L21SP3_RS07620	COG0811	peptide transport
L21SP3_RS07645	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
L21SP3_RS07655	COG0154	amidase activity
L21SP3_RS07675	COG1528	Iron-storage protein
L21SP3_RS07680	COG2033	superoxide reductase activity
L21SP3_RS07685	COG0426	domain, Protein
L21SP3_RS07690	COG1592	Rubrerythrin
L21SP3_RS07695	COG0735	belongs to the Fur family
L21SP3_RS07725	COG1137	ATPase activity
L21SP3_RS07730	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
L21SP3_RS07740	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
L21SP3_RS07745	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L21SP3_RS07760	COG0187	DNA topoisomerase II activity
L21SP3_RS07770	COG1674	ftsk spoiiie
L21SP3_RS07775	COG1105	Belongs to the carbohydrate kinase PfkB family
L21SP3_RS07805	COG0531	amino acid
L21SP3_RS07810	COG3250	beta-galactosidase activity
L21SP3_RS07820	COG3525	Glycosyl hydrolase, family 20, catalytic domain
L21SP3_RS07835	COG1322	Protein conserved in bacteria
L21SP3_RS07845	COG1509	lysine 2,3-aminomutase activity
L21SP3_RS07885	COG0698	ribose 5-phosphate isomerase
L21SP3_RS07910	COG0004	ammonium transporteR
L21SP3_RS07915	COG0347	Belongs to the P(II) protein family
L21SP3_RS07990	COG3119	arylsulfatase activity
L21SP3_RS07995	COG0191	fructose-bisphosphate aldolase activity
L21SP3_RS08000	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
L21SP3_RS08015	COG1966	Carbon starvation protein
L21SP3_RS08020	COG0275	rRNA processing
L21SP3_RS08035	COG1028	Short-chain dehydrogenase reductase Sdr
L21SP3_RS08040	COG1088	dTDP-glucose 4,6-dehydratase activity
L21SP3_RS08045	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
L21SP3_RS08050	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
L21SP3_RS08055	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
L21SP3_RS08080	COG0860	N-Acetylmuramoyl-L-alanine amidase
L21SP3_RS08085	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
L21SP3_RS08110	COG3119	arylsulfatase activity
L21SP3_RS08155	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
L21SP3_RS08180	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
L21SP3_RS08190	COG3119	arylsulfatase activity
L21SP3_RS08195	COG3119	arylsulfatase activity
L21SP3_RS08210	COG4948	Mandelate Racemase Muconate Lactonizing
L21SP3_RS08215	COG0523	cobalamin synthesis protein
L21SP3_RS08225	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
L21SP3_RS08230	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L21SP3_RS08240	COG0215	cysteine-tRNA ligase activity
L21SP3_RS08255	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
L21SP3_RS08260	COG3328	transposase activity
L21SP3_RS08265	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
L21SP3_RS08285	COG0596	Alpha beta hydrolase
L21SP3_RS08340	COG2165	general secretion pathway protein
L21SP3_RS08370	COG0716	FMN binding
L21SP3_RS08415	COG2165	general secretion pathway protein
L21SP3_RS08430	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
L21SP3_RS08450	COG2176	DNA-directed DNA polymerase activity
L21SP3_RS08470	COG1129	ABC transporter
L21SP3_RS08510	COG2165	general secretion pathway protein
L21SP3_RS08515	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
L21SP3_RS08520	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
L21SP3_RS08530	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
L21SP3_RS08535	COG1120	ATPase activity
L21SP3_RS08540	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L21SP3_RS08545	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
L21SP3_RS08550	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
L21SP3_RS08555	COG1492	cobalamin metabolic process
L21SP3_RS08565	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
L21SP3_RS08575	COG3415	Transposase
L21SP3_RS08595	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
L21SP3_RS08600	COG1477	protein flavinylation
L21SP3_RS08620	COG1262	PFAM Formylglycine-generating sulfatase enzyme
L21SP3_RS08620	COG0515	serine threonine protein kinase
L21SP3_RS08640	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
L21SP3_RS08645	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
L21SP3_RS08650	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
L21SP3_RS08660	COG3250	beta-galactosidase activity
L21SP3_RS08670	COG5609	conserved protein (DUF2294)
L21SP3_RS08680	COG0077	Prephenate dehydratase
L21SP3_RS08680	COG1605	Chorismate mutase
L21SP3_RS08685	COG0149	triose-phosphate isomerase activity
L21SP3_RS08695	COG1561	YicC-like family, N-terminal region
L21SP3_RS08705	COG1758	RNA polymerase activity
L21SP3_RS08710	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
L21SP3_RS08715	COG0793	Belongs to the peptidase S41A family
L21SP3_RS08725	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
L21SP3_RS08730	COG3119	arylsulfatase activity
L21SP3_RS08735	COG3119	arylsulfatase activity
L21SP3_RS08740	COG3119	arylsulfatase activity
L21SP3_RS08755	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
L21SP3_RS08765	COG2183	response to ionizing radiation
L21SP3_RS08780	COG0165	Argininosuccinate lyase
L21SP3_RS08790	COG0285	dihydrofolate synthase activity
L21SP3_RS08800	COG0261	This protein binds to 23S rRNA in the presence of protein L20
L21SP3_RS08805	COG4974	Belongs to the 'phage' integrase family
L21SP3_RS08810	COG2871	sodium ion transport
L21SP3_RS08825	COG0066	3-isopropylmalate dehydratase activity
L21SP3_RS08830	COG2165	general secretion pathway protein
L21SP3_RS08845	COG3119	arylsulfatase activity
L21SP3_RS08860	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L21SP3_RS08870	COG1538	Outer membrane efflux protein
L21SP3_RS08880	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L21SP3_RS08895	COG3250	beta-galactosidase activity
L21SP3_RS08915	COG1129	ABC transporter
L21SP3_RS08920	COG1172	Belongs to the binding-protein-dependent transport system permease family
L21SP3_RS08930	COG4452	Inner membrane protein CreD
L21SP3_RS08950	COG0105	UTP biosynthetic process
L21SP3_RS08955	COG0307	riboflavin synthase, alpha
L21SP3_RS08965	COG1074	ATP-dependent DNA helicase activity
L21SP3_RS08970	COG0386	Belongs to the glutathione peroxidase family
L21SP3_RS08985	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
L21SP3_RS08990	COG1475	DNA binding
L21SP3_RS09025	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
L21SP3_RS09035	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
L21SP3_RS09040	COG0463	Glycosyl transferase, family 2
L21SP3_RS09065	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
L21SP3_RS09095	COG1120	ATPase activity
L21SP3_RS09100	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
L21SP3_RS09105	COG3494	Protein of unknown function (DUF1009)
L21SP3_RS09110	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L21SP3_RS09120	COG1013	pyruvate-flavodoxin oxidoreductase activity
L21SP3_RS09145	COG2826	transposase and inactivated derivatives, IS30 family
L21SP3_RS09160	COG4956	integral membrane protein (PIN domain superfamily)
L21SP3_RS09165	COG2088	sporulation resulting in formation of a cellular spore
L21SP3_RS09170	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
L21SP3_RS09195	COG0489	protein tyrosine kinase activity
L21SP3_RS09230	COG3250	beta-galactosidase activity
L21SP3_RS09245	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
L21SP3_RS09250	COG0653	protein targeting
L21SP3_RS09265	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L21SP3_RS09285	COG2165	general secretion pathway protein
L21SP3_RS09315	COG0723	plastoquinol--plastocyanin reductase activity
L21SP3_RS09315	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L21SP3_RS09330	COG4948	Mandelate Racemase Muconate Lactonizing
L21SP3_RS09340	COG1609	Transcriptional regulator
L21SP3_RS09340	COG2207	Transcriptional regulator
L21SP3_RS09350	COG3119	arylsulfatase activity
L21SP3_RS09385	COG0012	GTP binding
L21SP3_RS09390	COG0357	Ribosomal RNA small subunit methyltransferase G
L21SP3_RS09395	COG4974	Belongs to the 'phage' integrase family
L21SP3_RS09400	COG2195	Cleaves the N-terminal amino acid of tripeptides
L21SP3_RS09405	COG0428	transporter
L21SP3_RS09410	COG3119	arylsulfatase activity
L21SP3_RS09435	COG1086	Polysaccharide biosynthesis protein
L21SP3_RS09445	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
L21SP3_RS09460	COG0531	amino acid
L21SP3_RS09465	COG0557	exoribonuclease II activity
L21SP3_RS09480	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
L21SP3_RS09495	COG2826	transposase and inactivated derivatives, IS30 family
L21SP3_RS09525	COG1408	metallophosphoesterase
L21SP3_RS09530	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
L21SP3_RS09535	COG0525	valine-tRNA ligase activity
L21SP3_RS09545	COG3119	arylsulfatase activity
L21SP3_RS09580	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
L21SP3_RS09585	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
L21SP3_RS09605	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
L21SP3_RS09620	COG2801	Transposase and inactivated derivatives
L21SP3_RS09630	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
L21SP3_RS09640	COG3119	arylsulfatase activity
L21SP3_RS09645	COG2731	YhcH YjgK YiaL family protein
L21SP3_RS09660	COG2165	general secretion pathway protein
L21SP3_RS09665	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L21SP3_RS09670	COG0546	phosphoglycolate phosphatase activity
L21SP3_RS09690	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
L21SP3_RS09690	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L21SP3_RS09720	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
L21SP3_RS09725	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
L21SP3_RS09730	COG3119	arylsulfatase activity
L21SP3_RS09750	COG2165	general secretion pathway protein
L21SP3_RS09755	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
L21SP3_RS09760	COG1132	(ABC) transporter
L21SP3_RS09780	COG0101	tRNA pseudouridine synthase activity
L21SP3_RS09785	COG0436	Aminotransferase
L21SP3_RS09795	COG0632	four-way junction helicase activity
L21SP3_RS09800	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
L21SP3_RS09805	COG0358	DNA primase activity
L21SP3_RS09820	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
L21SP3_RS09825	COG0018	arginyl-trna synthetase
L21SP3_RS09835	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
L21SP3_RS09840	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
L21SP3_RS09845	COG0142	geranyltranstransferase activity
L21SP3_RS09850	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
L21SP3_RS09870	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
L21SP3_RS09875	COG0658	competence protein
L21SP3_RS09875	COG2333	competence protein COMEC
L21SP3_RS09880	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
L21SP3_RS09890	COG0322	excinuclease ABC activity
L21SP3_RS09905	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
L21SP3_RS09910	COG1785	Belongs to the alkaline phosphatase family
L21SP3_RS09915	COG1609	Transcriptional regulator
L21SP3_RS09915	COG2207	Transcriptional regulator
L21SP3_RS09935	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
L21SP3_RS09955	COG1960	acyl-CoA dehydrogenase activity
L21SP3_RS09960	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
L21SP3_RS09965	COG2086	electron transfer activity
L21SP3_RS09970	COG0483	inositol monophosphate 1-phosphatase activity
L21SP3_RS10020	COG2826	transposase and inactivated derivatives, IS30 family
L21SP3_RS10075	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
L21SP3_RS10080	COG3250	beta-galactosidase activity
L21SP3_RS10100	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L21SP3_RS10125	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
L21SP3_RS10130	COG3119	arylsulfatase activity
L21SP3_RS10145	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L21SP3_RS10150	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
L21SP3_RS10160	COG2382	esterase
L21SP3_RS10175	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
L21SP3_RS10180	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
L21SP3_RS10185	COG0195	Participates in both transcription termination and antitermination
L21SP3_RS10195	COG0768	penicillin binding
L21SP3_RS10210	COG5012	cobalamin binding
L21SP3_RS10215	COG2848	UPF0210 protein
L21SP3_RS10255	COG1131	(ABC) transporter
L21SP3_RS10275	COG0733	neurotransmitter:sodium symporter activity
L21SP3_RS10280	COG1181	Belongs to the D-alanine--D-alanine ligase family
L21SP3_RS10305	COG2826	transposase and inactivated derivatives, IS30 family
L21SP3_RS10320	COG0352	thiamine-phosphate diphosphorylase activity
L21SP3_RS10330	COG1381	Involved in DNA repair and RecF pathway recombination
L21SP3_RS10370	COG2204	response regulator
L21SP3_RS10380	COG0446	pyridine nucleotide-disulphide oxidoreductase
L21SP3_RS10390	COG3706	GGDEF domain
L21SP3_RS10395	COG1056	cytidyltransferase-related domain
L21SP3_RS10395	COG1051	belongs to the nudix hydrolase family
L21SP3_RS10410	COG1862	Preprotein translocase
L21SP3_RS10415	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
L21SP3_RS10430	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
L21SP3_RS10435	COG3507	Belongs to the glycosyl hydrolase 43 family
L21SP3_RS10445	COG2198	Histidine kinase
L21SP3_RS10445	COG0784	Response regulator, receiver
L21SP3_RS10445	COG5002	protein histidine kinase activity
L21SP3_RS10465	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
L21SP3_RS10480	COG1609	Transcriptional regulator
L21SP3_RS10490	COG2165	general secretion pathway protein
L21SP3_RS10505	COG0673	inositol 2-dehydrogenase activity
L21SP3_RS10515	COG0584	glycerophosphoryl diester phosphodiesterase
L21SP3_RS10565	COG3507	Belongs to the glycosyl hydrolase 43 family
L21SP3_RS10575	COG1217	gtp-binding protein TYPA
L21SP3_RS10580	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
L21SP3_RS10590	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
L21SP3_RS10590	COG0574	Belongs to the PEP-utilizing enzyme family
L21SP3_RS10605	COG0543	2 iron, 2 sulfur cluster binding
L21SP3_RS10610	COG0167	dihydroorotate dehydrogenase activity
L21SP3_RS10620	COG2826	transposase and inactivated derivatives, IS30 family
L21SP3_RS10625	COG0628	permease
L21SP3_RS10630	COG1160	GTP binding
L21SP3_RS10635	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
L21SP3_RS10650	COG3119	arylsulfatase activity
L21SP3_RS10655	COG3250	beta-galactosidase activity
L21SP3_RS10660	COG1472	Belongs to the glycosyl hydrolase 3 family
L21SP3_RS10670	COG3507	Belongs to the glycosyl hydrolase 43 family
L21SP3_RS10680	COG2814	Major facilitator Superfamily
L21SP3_RS10730	COG1940	carbohydrate kinase activity
L21SP3_RS10750	COG0267	Belongs to the bacterial ribosomal protein bL33 family
L21SP3_RS10765	COG0250	Participates in transcription elongation, termination and antitermination
L21SP3_RS10770	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
L21SP3_RS10775	COG0081	regulation of translation
L21SP3_RS10785	COG0222	ribosome binding
L21SP3_RS10790	COG0085	RNA polymerase activity
L21SP3_RS10795	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
L21SP3_RS10800	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
L21SP3_RS10805	COG0049	tRNA binding
L21SP3_RS10815	COG2205	protein histidine kinase activity
L21SP3_RS10815	COG2202	Pas domain
L21SP3_RS10820	COG0667	Aldo Keto reductase
L21SP3_RS10825	COG0508	dehydrogenase complex catalyzes the overall conversion of
L21SP3_RS10840	COG0445	tRNA wobble uridine modification
L21SP3_RS10845	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
L21SP3_RS10860	COG2814	Major facilitator Superfamily
L21SP3_RS10865	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L21SP3_RS10870	COG1621	beta-fructofuranosidase activity
L21SP3_RS10935	COG3250	beta-galactosidase activity
L21SP3_RS10950	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
L21SP3_RS10955	COG3119	arylsulfatase activity
L21SP3_RS10960	COG3119	arylsulfatase activity
L21SP3_RS10965	COG0220	tRNA (guanine-N7-)-methyltransferase activity
L21SP3_RS10990	COG0297	glycogen (starch) synthase activity
L21SP3_RS11000	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
L21SP3_RS11010	COG2208	phosphoserine phosphatase activity
L21SP3_RS11015	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
L21SP3_RS11020	COG4251	negative regulation of phosphorylation
L21SP3_RS11030	COG0300	oxidoreductase activity
L21SP3_RS11035	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
L21SP3_RS11045	COG0704	Plays a role in the regulation of phosphate uptake
L21SP3_RS11055	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
L21SP3_RS11065	COG0573	inorganic phosphate transmembrane transporter activity
L21SP3_RS11095	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
L21SP3_RS11100	COG4251	negative regulation of phosphorylation
L21SP3_RS11105	COG4251	negative regulation of phosphorylation
L21SP3_RS11120	COG0820	rRNA (adenine-C2-)-methyltransferase activity
L21SP3_RS11130	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L21SP3_RS11145	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
L21SP3_RS11150	COG1692	metallophosphoesterase
L21SP3_RS11155	COG0248	Ppx GppA phosphatase
L21SP3_RS11160	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
L21SP3_RS11180	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
L21SP3_RS11205	COG3119	arylsulfatase activity
L21SP3_RS11210	COG3119	arylsulfatase activity
L21SP3_RS11220	COG3119	arylsulfatase activity
L21SP3_RS11225	COG3940	Belongs to the glycosyl hydrolase 43 family
L21SP3_RS11230	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
L21SP3_RS11240	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L21SP3_RS11275	COG0564	pseudouridine synthase activity
L21SP3_RS11295	COG0488	(ABC) transporter
L21SP3_RS11310	COG0069	glutamate synthase activity
L21SP3_RS11310	COG0067	glutamate synthase
L21SP3_RS11310	COG0070	glutamate synthase
L21SP3_RS11320	COG0828	Belongs to the bacterial ribosomal protein bS21 family
L21SP3_RS11375	COG1595	DNA-templated transcription, initiation
L21SP3_RS11385	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
L21SP3_RS11390	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L21SP3_RS11525	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
L21SP3_RS11540	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
L21SP3_RS11555	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
L21SP3_RS11560	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
L21SP3_RS11570	COG0736	holo-[acyl-carrier-protein] synthase activity
L21SP3_RS11585	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
L21SP3_RS11595	COG0745	RESPONSE REGULATOR receiver
L21SP3_RS11600	COG5002	protein histidine kinase activity
L21SP3_RS11605	COG3345	alpha-galactosidase
L21SP3_RS11615	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
L21SP3_RS11640	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
L21SP3_RS11645	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
L21SP3_RS11705	COG2801	Transposase and inactivated derivatives
L21SP3_RS11755	COG3177	Filamentation induced by cAMP protein fic
L21SP3_RS11760	COG0084	hydrolase, TatD family'
L21SP3_RS11775	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
L21SP3_RS11780	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
L21SP3_RS11780	COG0644	oxidoreductase
L21SP3_RS11795	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
L21SP3_RS11800	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
L21SP3_RS11800	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons