locus-tag	class	description
STSP1_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
STSP1_RS00020	COG0318	PFAM AMP-dependent synthetase and ligase
STSP1_RS00030	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
STSP1_RS00055	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
STSP1_RS00070	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
STSP1_RS00075	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
STSP1_RS00085	COG0635	Involved in the biosynthesis of porphyrin-containing compound
STSP1_RS00100	COG3119	arylsulfatase activity
STSP1_RS00105	COG3119	arylsulfatase activity
STSP1_RS00115	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
STSP1_RS00140	COG1720	tRNA m6t6A37 methyltransferase activity
STSP1_RS00145	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
STSP1_RS00160	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
STSP1_RS00160	COG3264	Mechanosensitive ion channel
STSP1_RS00170	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
STSP1_RS00175	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
STSP1_RS00175	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
STSP1_RS00205	COG0745	RESPONSE REGULATOR receiver
STSP1_RS00220	COG3250	beta-galactosidase activity
STSP1_RS00235	COG0348	domain, Protein
STSP1_RS00260	COG0792	nuclease activity
STSP1_RS00265	COG0335	large ribosomal subunit rRNA binding
STSP1_RS00270	COG0336	Belongs to the RNA methyltransferase TrmD family
STSP1_RS00275	COG0228	four-way junction DNA binding
STSP1_RS00285	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
STSP1_RS00320	COG1013	pyruvate-flavodoxin oxidoreductase activity
STSP1_RS00320	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
STSP1_RS00320	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
STSP1_RS00320	COG0674	pyruvate-flavodoxin oxidoreductase activity
STSP1_RS00330	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
STSP1_RS00340	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
STSP1_RS00345	COG1028	Short-chain dehydrogenase reductase Sdr
STSP1_RS00375	COG4145	pantothenate transmembrane transporter activity
STSP1_RS00380	COG4145	pantothenate transmembrane transporter activity
STSP1_RS00385	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
STSP1_RS00390	COG0254	rRNA binding
STSP1_RS00400	COG1450	Type ii and iii secretion system protein
STSP1_RS00445	COG1459	type II secretion system
STSP1_RS00450	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
STSP1_RS00485	COG3250	beta-galactosidase activity
STSP1_RS00495	COG0552	protein localization to endoplasmic reticulum
STSP1_RS00515	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
STSP1_RS00515	COG0316	Belongs to the HesB IscA family
STSP1_RS00525	COG1663	tetraacyldisaccharide 4'-kinase activity
STSP1_RS00530	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
STSP1_RS00530	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
STSP1_RS00535	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
STSP1_RS00540	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
STSP1_RS00545	COG1127	ABC transporter
STSP1_RS00560	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
STSP1_RS00565	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
STSP1_RS00570	COG0193	aminoacyl-tRNA hydrolase activity
STSP1_RS00575	COG0360	Binds together with S18 to 16S ribosomal RNA
STSP1_RS00580	COG0629	single-stranded DNA binding
STSP1_RS00585	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
STSP1_RS00590	COG0359	binds to the 23S rRNA
STSP1_RS00595	COG0305	Participates in initiation and elongation during chromosome replication
STSP1_RS00620	COG0107	imidazoleglycerol-phosphate synthase activity
STSP1_RS00625	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
STSP1_RS00630	COG0667	Aldo Keto reductase
STSP1_RS00645	COG1609	Transcriptional regulator
STSP1_RS00655	COG0383	alpha-mannosidase activity
STSP1_RS00670	COG1609	Transcriptional regulator
STSP1_RS00685	COG2165	general secretion pathway protein
STSP1_RS00690	COG2165	general secretion pathway protein
STSP1_RS00720	COG3119	arylsulfatase activity
STSP1_RS00745	COG0383	alpha-mannosidase activity
STSP1_RS00750	COG0446	pyridine nucleotide-disulphide oxidoreductase
STSP1_RS00750	COG0404	The glycine cleavage system catalyzes the degradation of glycine
STSP1_RS00805	COG2183	response to ionizing radiation
STSP1_RS00805	COG0539	negative regulation of cytoplasmic translation
STSP1_RS00810	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
STSP1_RS00815	COG1253	flavin adenine dinucleotide binding
STSP1_RS00820	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
STSP1_RS00825	COG0180	Tryptophanyl-tRNA synthetase
STSP1_RS00830	COG0366	Alpha amylase catalytic
STSP1_RS00835	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
STSP1_RS00840	COG0297	glycogen (starch) synthase activity
STSP1_RS00855	COG0657	acetylesterase activity
STSP1_RS00855	COG2755	lipolytic protein G-D-S-L family
STSP1_RS00860	COG2878	Part of a membrane complex involved in electron transport
STSP1_RS00865	COG4657	Part of a membrane complex involved in electron transport
STSP1_RS00870	COG4660	Part of a membrane complex involved in electron transport
STSP1_RS00875	COG4659	FMN binding
STSP1_RS00880	COG4658	electron transport chain
STSP1_RS00885	COG4656	Part of a membrane complex involved in electron transport
STSP1_RS00905	COG2207	Transcriptional regulator
STSP1_RS00905	COG1609	Transcriptional regulator
STSP1_RS00910	COG2160	L-arabinose isomerase activity
STSP1_RS00920	COG3401	FG-GAP repeat protein
STSP1_RS00935	COG3534	alpha-L-arabinofuranosidase
STSP1_RS00950	COG1595	DNA-templated transcription, initiation
STSP1_RS00955	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
STSP1_RS00955	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
STSP1_RS00970	COG3119	arylsulfatase activity
STSP1_RS00975	COG4608	Belongs to the ABC transporter superfamily
STSP1_RS00980	COG0444	Belongs to the ABC transporter superfamily
STSP1_RS00995	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
STSP1_RS01045	COG0745	RESPONSE REGULATOR receiver
STSP1_RS01055	COG0297	glycogen (starch) synthase activity
STSP1_RS01065	COG0438	transferase activity, transferring glycosyl groups
STSP1_RS01070	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
STSP1_RS01075	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
STSP1_RS01090	COG0572	uridine kinase
STSP1_RS01155	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
STSP1_RS01160	COG2165	general secretion pathway protein
STSP1_RS01170	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
STSP1_RS01190	COG4948	Mandelate Racemase Muconate Lactonizing
STSP1_RS01205	COG0673	inositol 2-dehydrogenase activity
STSP1_RS01215	COG0673	inositol 2-dehydrogenase activity
STSP1_RS01225	COG0508	dehydrogenase complex catalyzes the overall conversion of
STSP1_RS01230	COG1410	methionine synthase
STSP1_RS01230	COG0646	methionine synthase
STSP1_RS01245	COG1573	uracil-dna glycosylase
STSP1_RS01255	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
STSP1_RS01260	COG1309	transcriptional regulator
STSP1_RS01295	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
STSP1_RS01315	COG0463	Glycosyl transferase, family 2
STSP1_RS01320	COG1215	transferase activity, transferring glycosyl groups
STSP1_RS01335	COG0194	GDP metabolic process
STSP1_RS01385	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
STSP1_RS01390	COG0857	belongs to the CobB CobQ family
STSP1_RS01390	COG0280	phosphate acetyltransferase
STSP1_RS01395	COG0205	6-phosphofructokinase activity
STSP1_RS01405	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
STSP1_RS01410	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
STSP1_RS01445	COG1027	Aspartate ammonia-lyase
STSP1_RS01450	COG1088	dTDP-glucose 4,6-dehydratase activity
STSP1_RS01460	COG0302	gtp cyclohydrolase
STSP1_RS01485	COG1940	carbohydrate kinase activity
STSP1_RS01500	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
STSP1_RS01510	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
STSP1_RS01525	COG2273	Hydrolase Family 16
STSP1_RS01535	COG0432	Pfam Uncharacterised protein family UPF0047
STSP1_RS01545	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
STSP1_RS01560	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
STSP1_RS01565	COG0084	hydrolase, TatD family'
STSP1_RS01575	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
STSP1_RS01610	COG0402	S-adenosylhomocysteine deaminase activity
STSP1_RS01620	COG1595	DNA-templated transcription, initiation
STSP1_RS01645	COG2165	general secretion pathway protein
STSP1_RS01650	COG1940	carbohydrate kinase activity
STSP1_RS01670	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
STSP1_RS01680	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
STSP1_RS01690	COG0205	6-phosphofructokinase activity
STSP1_RS01695	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
STSP1_RS01705	COG1482	cell wall glycoprotein biosynthetic process
STSP1_RS01715	COG0321	lipoyl(octanoyl) transferase activity
STSP1_RS01720	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
STSP1_RS01730	COG0284	orotidine-5'-phosphate decarboxylase activity
STSP1_RS01735	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
STSP1_RS01740	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
STSP1_RS01745	COG1722	exodeoxyribonuclease VII activity
STSP1_RS01760	COG2963	transposase activity
STSP1_RS01780	COG1160	GTP binding
STSP1_RS01790	COG0372	Belongs to the citrate synthase family
STSP1_RS01800	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
STSP1_RS01805	COG1404	Belongs to the peptidase S8 family
STSP1_RS01815	COG0019	diaminopimelate decarboxylase activity
STSP1_RS01820	COG0724	RNA recognition motif
STSP1_RS01825	COG0481	GTPase activity
STSP1_RS01830	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
STSP1_RS01840	COG0504	CTP synthase activity
STSP1_RS01845	COG0698	ribose 5-phosphate isomerase
STSP1_RS01880	COG0330	HflC and HflK could
STSP1_RS01905	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
STSP1_RS01915	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
STSP1_RS01920	COG4251	negative regulation of phosphorylation
STSP1_RS01935	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
STSP1_RS01940	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
STSP1_RS01960	COG1904	glucuronate isomerase
STSP1_RS01965	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
STSP1_RS01970	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
STSP1_RS01980	COG1028	Short-chain dehydrogenase reductase Sdr
STSP1_RS01985	COG1940	carbohydrate kinase activity
STSP1_RS01995	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
STSP1_RS02015	COG1501	Belongs to the glycosyl hydrolase 31 family
STSP1_RS02030	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
STSP1_RS02030	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
STSP1_RS02035	COG1691	(AIR) carboxylase
STSP1_RS02045	COG0148	phosphopyruvate hydratase activity
STSP1_RS02050	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
STSP1_RS02060	COG0131	Imidazoleglycerol-phosphate dehydratase
STSP1_RS02060	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
STSP1_RS02070	COG0126	phosphoglycerate kinase activity
STSP1_RS02090	COG0287	Prephenate dehydrogenase
STSP1_RS02100	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
STSP1_RS02110	COG1595	DNA-templated transcription, initiation
STSP1_RS02120	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
STSP1_RS02120	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
STSP1_RS02130	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
STSP1_RS02150	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
STSP1_RS02155	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
STSP1_RS02175	COG0210	DNA helicase
STSP1_RS02190	COG1131	(ABC) transporter
STSP1_RS02200	COG0330	HflC and HflK could
STSP1_RS02205	COG0330	HflC and HflK could
STSP1_RS02220	COG0202	RNA polymerase activity
STSP1_RS02225	COG2385	sporulation resulting in formation of a cellular spore
STSP1_RS02230	COG0343	queuine tRNA-ribosyltransferase activity
STSP1_RS02235	COG0047	phosphoribosylformylglycinamidine synthase activity
STSP1_RS02240	COG0668	transmembrane transport
STSP1_RS02255	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
STSP1_RS02270	COG0544	peptidyl-prolyl cis-trans isomerase activity
STSP1_RS02275	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
STSP1_RS02280	COG0166	Belongs to the GPI family
STSP1_RS02290	COG4284	Utp--glucose-1-phosphate uridylyltransferase
STSP1_RS02300	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
STSP1_RS02305	COG1454	alcohol dehydrogenase
STSP1_RS02305	COG1012	belongs to the aldehyde dehydrogenase family
STSP1_RS02315	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
STSP1_RS02325	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
STSP1_RS02335	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
STSP1_RS02370	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
STSP1_RS02385	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
STSP1_RS02400	COG1045	serine acetyltransferase
STSP1_RS02410	COG1959	2 iron, 2 sulfur cluster binding
STSP1_RS02415	COG0731	radical SAM domain protein
STSP1_RS02415	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
STSP1_RS02420	COG2877	3-deoxy-8-phosphooctulonate synthase activity
STSP1_RS02430	COG1394	ATPase activity, coupled to movement of substances
STSP1_RS02435	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
STSP1_RS02440	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
STSP1_RS02465	COG1269	ATP hydrolysis coupled proton transport
STSP1_RS02490	COG0784	Response regulator, receiver
STSP1_RS02500	COG0727	PFAM Uncharacterised protein family (UPF0153)
STSP1_RS02515	COG0356	it plays a direct role in the translocation of protons across the membrane
STSP1_RS02520	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
STSP1_RS02530	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
STSP1_RS02535	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
STSP1_RS02545	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
STSP1_RS02550	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
STSP1_RS02555	COG0355	proton-transporting ATP synthase activity, rotational mechanism
STSP1_RS02580	COG2826	transposase and inactivated derivatives, IS30 family
STSP1_RS02585	COG1621	beta-fructofuranosidase activity
STSP1_RS02635	COG0395	ABC-type sugar transport system, permease component
STSP1_RS02640	COG1175	transmembrane transport
STSP1_RS02650	COG3842	ATPase activity
STSP1_RS02670	COG3119	arylsulfatase activity
STSP1_RS02675	COG3119	arylsulfatase activity
STSP1_RS02690	COG2165	general secretion pathway protein
STSP1_RS02720	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
STSP1_RS02735	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
STSP1_RS02785	COG3119	arylsulfatase activity
STSP1_RS02790	COG3940	Belongs to the glycosyl hydrolase 43 family
STSP1_RS02795	COG3507	Belongs to the glycosyl hydrolase 43 family
STSP1_RS02805	COG3119	arylsulfatase activity
STSP1_RS02810	COG3119	arylsulfatase activity
STSP1_RS02815	COG3537	Alpha-1,2-mannosidase
STSP1_RS02865	COG0473	3-isopropylmalate dehydrogenase activity
STSP1_RS02875	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
STSP1_RS02890	COG0784	Response regulator, receiver
STSP1_RS02890	COG5002	protein histidine kinase activity
STSP1_RS02890	COG2198	Histidine kinase
STSP1_RS02895	COG3507	Belongs to the glycosyl hydrolase 43 family
STSP1_RS02915	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
STSP1_RS02920	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
STSP1_RS02930	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
STSP1_RS02935	COG0140	phosphoribosyl-ATP diphosphatase activity
STSP1_RS02950	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
STSP1_RS02950	COG1918	ferrous iron import across plasma membrane
STSP1_RS02975	COG1609	Transcriptional regulator
STSP1_RS02975	COG2207	Transcriptional regulator
STSP1_RS02980	COG3534	alpha-L-arabinofuranosidase
STSP1_RS02985	COG0812	UDP-N-acetylmuramate dehydrogenase activity
STSP1_RS02990	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
STSP1_RS02995	COG1360	Flagellar Motor Protein
STSP1_RS03030	COG0601	transmembrane transport
STSP1_RS03035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
STSP1_RS03050	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
STSP1_RS03070	COG2207	Transcriptional regulator
STSP1_RS03070	COG1609	Transcriptional regulator
STSP1_RS03075	COG3250	beta-galactosidase activity
STSP1_RS03090	COG2165	general secretion pathway protein
STSP1_RS03095	COG1131	(ABC) transporter
STSP1_RS03115	COG1940	carbohydrate kinase activity
STSP1_RS03180	COG2814	Major facilitator Superfamily
STSP1_RS03190	COG3507	Belongs to the glycosyl hydrolase 43 family
STSP1_RS03200	COG1472	Belongs to the glycosyl hydrolase 3 family
STSP1_RS03205	COG2115	Belongs to the xylose isomerase family
STSP1_RS03210	COG1070	Carbohydrate kinase
STSP1_RS03215	COG1609	Transcriptional regulator
STSP1_RS03215	COG2207	Transcriptional regulator
STSP1_RS03310	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
STSP1_RS03355	COG0438	transferase activity, transferring glycosyl groups
STSP1_RS03370	COG2843	Capsule synthesis protein
STSP1_RS03410	COG0463	Glycosyl transferase, family 2
STSP1_RS03450	COG0052	Belongs to the universal ribosomal protein uS2 family
STSP1_RS03455	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
STSP1_RS03460	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
STSP1_RS03470	COG3119	arylsulfatase activity
STSP1_RS03475	COG1472	Belongs to the glycosyl hydrolase 3 family
STSP1_RS03480	COG3344	reverse transcriptase
STSP1_RS03495	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
STSP1_RS03535	COG3119	arylsulfatase activity
STSP1_RS03540	COG3119	arylsulfatase activity
STSP1_RS03560	COG0740	serine-type endopeptidase activity
STSP1_RS03565	COG0740	serine-type endopeptidase activity
STSP1_RS03570	COG0543	2 iron, 2 sulfur cluster binding
STSP1_RS03575	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
STSP1_RS03575	COG0493	'glutamate synthase
STSP1_RS03580	COG0443	Heat shock 70 kDa protein
STSP1_RS03595	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
STSP1_RS03610	COG1069	ribulokinase activity
STSP1_RS03620	COG3119	arylsulfatase activity
STSP1_RS03630	COG1238	metal cluster binding
STSP1_RS03650	COG2197	response regulator
STSP1_RS03655	COG4585	Histidine kinase
STSP1_RS03665	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
STSP1_RS03665	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
STSP1_RS03675	COG0330	HflC and HflK could
STSP1_RS03685	COG2873	o-acetylhomoserine
STSP1_RS03700	COG4106	trans-aconitate 2-methyltransferase activity
STSP1_RS03705	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
STSP1_RS03715	COG2895	sulfate adenylyltransferase (ATP) activity
STSP1_RS03735	COG0175	sulfate reduction
STSP1_RS03740	COG0232	Belongs to the dGTPase family. Type 2 subfamily
STSP1_RS03765	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
STSP1_RS03765	COG2813	Specifically methylates the guanine in position
STSP1_RS03780	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
STSP1_RS03780	COG0512	Glutamine amidotransferase of anthranilate synthase
STSP1_RS03785	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
STSP1_RS03790	COG0134	indole-3-glycerol-phosphate synthase activity
STSP1_RS03795	COG0135	phosphoribosylanthranilate isomerase activity
STSP1_RS03805	COG0159	tryptophan synthase activity
STSP1_RS03810	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
STSP1_RS03815	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
STSP1_RS03820	COG1028	Short-chain dehydrogenase reductase Sdr
STSP1_RS03825	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
STSP1_RS03830	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
STSP1_RS03835	COG0416	fatty acid biosynthetic process
STSP1_RS03840	COG0333	Belongs to the bacterial ribosomal protein bL32 family
STSP1_RS03845	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
STSP1_RS03850	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
STSP1_RS03855	COG0131	Imidazoleglycerol-phosphate dehydratase
STSP1_RS03860	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
STSP1_RS03880	COG1215	transferase activity, transferring glycosyl groups
STSP1_RS03885	COG1216	Glycosyl transferase, family 2
STSP1_RS03885	COG0463	Glycosyl transferase, family 2
STSP1_RS03890	COG1216	Glycosyl transferase, family 2
STSP1_RS03895	COG1442	glycosyl transferase family 8
STSP1_RS03895	COG1216	Glycosyl transferase, family 2
STSP1_RS03900	COG1216	Glycosyl transferase, family 2
STSP1_RS03905	COG0750	zinc metalloprotease
STSP1_RS03910	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
STSP1_RS03925	COG4796	Type ii and iii secretion system protein
STSP1_RS03930	COG1214	PFAM Peptidase M22, glycoprotease
STSP1_RS03940	COG3119	arylsulfatase activity
STSP1_RS03955	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
STSP1_RS03965	COG1872	DUF167
STSP1_RS04000	COG3119	arylsulfatase activity
STSP1_RS04005	COG3119	arylsulfatase activity
STSP1_RS04020	COG2207	Transcriptional regulator
STSP1_RS04020	COG1609	Transcriptional regulator
STSP1_RS04035	COG4537	Required for transformation and DNA binding
STSP1_RS04045	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
STSP1_RS04055	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
STSP1_RS04060	COG3119	arylsulfatase activity
STSP1_RS04065	COG3119	arylsulfatase activity
STSP1_RS04080	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
STSP1_RS04085	COG0805	protein transport
STSP1_RS04110	COG1321	iron dependent repressor
STSP1_RS04120	COG0450	alkyl hydroperoxide reductase
STSP1_RS04140	COG0542	response to heat
STSP1_RS04150	COG1994	Peptidase M50
STSP1_RS04160	COG1105	Belongs to the carbohydrate kinase PfkB family
STSP1_RS04165	COG1674	ftsk spoiiie
STSP1_RS04175	COG0187	DNA topoisomerase II activity
STSP1_RS04190	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
STSP1_RS04225	COG2198	Histidine kinase
STSP1_RS04225	COG5002	protein histidine kinase activity
STSP1_RS04225	COG0784	Response regulator, receiver
STSP1_RS04235	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
STSP1_RS04235	COG0758	DNA mediated transformation
STSP1_RS04240	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
STSP1_RS04245	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
STSP1_RS04255	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
STSP1_RS04260	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
STSP1_RS04260	COG0517	IMP dehydrogenase activity
STSP1_RS04265	COG1530	ribonuclease E activity
STSP1_RS04275	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
STSP1_RS04310	COG3250	beta-galactosidase activity
STSP1_RS04340	COG0215	cysteine-tRNA ligase activity
STSP1_RS04350	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
STSP1_RS04360	COG1401	restriction endodeoxyribonuclease activity
STSP1_RS04365	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
STSP1_RS04375	COG0820	rRNA (adenine-C2-)-methyltransferase activity
STSP1_RS04380	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
STSP1_RS04390	COG4251	negative regulation of phosphorylation
STSP1_RS04395	COG4251	negative regulation of phosphorylation
STSP1_RS04400	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
STSP1_RS04410	COG1199	ATP-dependent helicase activity
STSP1_RS04415	COG0606	chelatase, subunit chli
STSP1_RS04425	COG0864	Transcriptional regulator
STSP1_RS04440	COG2165	general secretion pathway protein
STSP1_RS04470	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
STSP1_RS04485	COG0655	NAD(P)H dehydrogenase (quinone) activity
STSP1_RS04555	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
STSP1_RS04585	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
STSP1_RS04585	COG0646	methionine synthase
STSP1_RS04590	COG1410	methionine synthase
STSP1_RS04590	COG0646	methionine synthase
STSP1_RS04595	COG3119	arylsulfatase activity
STSP1_RS04605	COG0220	tRNA (guanine-N7-)-methyltransferase activity
STSP1_RS04610	COG3119	arylsulfatase activity
STSP1_RS04615	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
STSP1_RS04640	COG1609	Transcriptional regulator
STSP1_RS04710	COG0573	inorganic phosphate transmembrane transporter activity
STSP1_RS04720	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
STSP1_RS04740	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
STSP1_RS04750	COG0495	leucyl-tRNA aminoacylation
STSP1_RS04785	COG2208	phosphoserine phosphatase activity
STSP1_RS04790	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
STSP1_RS04795	COG4251	negative regulation of phosphorylation
STSP1_RS04805	COG1028	Short-chain dehydrogenase reductase Sdr
STSP1_RS04810	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
STSP1_RS04820	COG0515	serine threonine protein kinase
STSP1_RS04820	COG1262	PFAM Formylglycine-generating sulfatase enzyme
STSP1_RS04835	COG1151	hydroxylamine reductase activity
STSP1_RS04845	COG1959	2 iron, 2 sulfur cluster binding
STSP1_RS04850	COG3250	beta-galactosidase activity
STSP1_RS04855	COG3119	arylsulfatase activity
STSP1_RS04860	COG0191	fructose-bisphosphate aldolase activity
STSP1_RS04870	COG0508	dehydrogenase complex catalyzes the overall conversion of
STSP1_RS04875	COG0667	Aldo Keto reductase
STSP1_RS04880	COG2202	Pas domain
STSP1_RS04880	COG2205	protein histidine kinase activity
STSP1_RS04905	COG0049	tRNA binding
STSP1_RS04910	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
STSP1_RS04915	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
STSP1_RS04920	COG0085	RNA polymerase activity
STSP1_RS04925	COG0222	ribosome binding
STSP1_RS04930	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
STSP1_RS04935	COG0081	regulation of translation
STSP1_RS04940	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
STSP1_RS04945	COG0250	Participates in transcription elongation, termination and antitermination
STSP1_RS04950	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
STSP1_RS04960	COG0267	Belongs to the bacterial ribosomal protein bL33 family
STSP1_RS04990	COG3250	beta-galactosidase activity
STSP1_RS05005	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
STSP1_RS05010	COG1160	GTP binding
STSP1_RS05015	COG0166	Belongs to the GPI family
STSP1_RS05045	COG0543	2 iron, 2 sulfur cluster binding
STSP1_RS05050	COG0167	dihydroorotate dehydrogenase activity
STSP1_RS05060	COG0628	permease
STSP1_RS05070	COG0445	tRNA wobble uridine modification
STSP1_RS05075	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
STSP1_RS05090	COG0477	Major facilitator Superfamily
STSP1_RS05090	COG2814	Major facilitator Superfamily
STSP1_RS05095	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
STSP1_RS05095	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
STSP1_RS05105	COG1621	beta-fructofuranosidase activity
STSP1_RS05110	COG1621	beta-fructofuranosidase activity
STSP1_RS05125	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
STSP1_RS05135	COG1051	belongs to the nudix hydrolase family
STSP1_RS05180	COG0736	holo-[acyl-carrier-protein] synthase activity
STSP1_RS05195	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
STSP1_RS05205	COG0745	RESPONSE REGULATOR receiver
STSP1_RS05210	COG5002	protein histidine kinase activity
STSP1_RS05215	COG3345	alpha-galactosidase
STSP1_RS05225	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
STSP1_RS05255	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
STSP1_RS05295	COG1518	maintenance of DNA repeat elements
STSP1_RS05305	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
STSP1_RS05310	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
STSP1_RS05325	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
STSP1_RS05335	COG0784	Response regulator, receiver
STSP1_RS05335	COG5002	protein histidine kinase activity
STSP1_RS05340	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
STSP1_RS05360	COG0714	Associated with various cellular activities
STSP1_RS05445	COG2723	6-phospho-beta-galactosidase activity
STSP1_RS05460	COG2207	Transcriptional regulator
STSP1_RS05485	COG1187	pseudouridine synthase activity
STSP1_RS05495	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
STSP1_RS05505	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
STSP1_RS05510	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
STSP1_RS05515	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
STSP1_RS05520	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
STSP1_RS05525	COG3387	PFAM Glycoside hydrolase 15-related
STSP1_RS05530	COG0438	transferase activity, transferring glycosyl groups
STSP1_RS05560	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
STSP1_RS05570	COG3119	arylsulfatase activity
STSP1_RS05595	COG0515	serine threonine protein kinase
STSP1_RS05595	COG1262	PFAM Formylglycine-generating sulfatase enzyme
STSP1_RS05615	COG3250	beta-galactosidase activity
STSP1_RS05620	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
STSP1_RS05625	COG3395	kinase activity
STSP1_RS05630	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
STSP1_RS05635	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
STSP1_RS05640	COG1454	alcohol dehydrogenase
STSP1_RS05645	COG1262	PFAM Formylglycine-generating sulfatase enzyme
STSP1_RS05680	COG1940	carbohydrate kinase activity
STSP1_RS05685	COG3119	arylsulfatase activity
STSP1_RS05695	COG2204	response regulator
STSP1_RS05700	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
STSP1_RS05730	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
STSP1_RS05735	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
STSP1_RS05750	COG1595	DNA-templated transcription, initiation
STSP1_RS05800	COG0616	signal peptide processing
STSP1_RS05810	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
STSP1_RS05820	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
STSP1_RS05825	COG0440	acetolactate synthase activity
STSP1_RS05830	COG0028	Belongs to the TPP enzyme family
STSP1_RS05835	COG1830	Aldolase
STSP1_RS05840	COG2165	general secretion pathway protein
STSP1_RS05850	COG0066	3-isopropylmalate dehydratase activity
STSP1_RS05870	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
STSP1_RS05875	COG0575	Belongs to the CDS family
STSP1_RS05880	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
STSP1_RS05890	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
STSP1_RS05895	COG0291	Belongs to the bacterial ribosomal protein bL35 family
STSP1_RS05900	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
STSP1_RS05905	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
STSP1_RS05915	COG1418	mRNA catabolic process
STSP1_RS05950	COG2022	thiamine diphosphate biosynthetic process
STSP1_RS05955	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
STSP1_RS05960	COG1959	2 iron, 2 sulfur cluster binding
STSP1_RS05985	COG0023	Translation Initiation Factor
STSP1_RS06005	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
STSP1_RS06005	COG0674	pyruvate-flavodoxin oxidoreductase activity
STSP1_RS06025	COG1234	tRNA 3'-trailer cleavage
STSP1_RS06035	COG2078	PFAM AMMECR1 domain protein
STSP1_RS06045	COG1882	Formate acetyltransferase
STSP1_RS06070	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
STSP1_RS06085	COG3869	Catalyzes the specific phosphorylation of arginine residues in
STSP1_RS06115	COG2113	Glycine betaine
STSP1_RS06155	COG2165	general secretion pathway protein
STSP1_RS06165	COG1560	Kdo2-lipid A biosynthetic process
STSP1_RS06170	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
STSP1_RS06200	COG2264	protein methyltransferase activity
STSP1_RS06215	COG3940	Belongs to the glycosyl hydrolase 43 family
STSP1_RS06220	COG3119	arylsulfatase activity
STSP1_RS06230	COG3119	arylsulfatase activity
STSP1_RS06235	COG3119	arylsulfatase activity
STSP1_RS06240	COG3119	arylsulfatase activity
STSP1_RS06250	COG5016	pyruvate
STSP1_RS06250	COG0511	ligase activity, forming carbon-carbon bonds
STSP1_RS06255	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
STSP1_RS06275	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
STSP1_RS06280	COG0248	Ppx GppA phosphatase
STSP1_RS06285	COG1692	metallophosphoesterase
STSP1_RS06290	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
STSP1_RS06325	COG0728	peptidoglycan biosynthetic process
STSP1_RS06355	COG0546	phosphoglycolate phosphatase activity
STSP1_RS06360	COG0012	GTP binding
STSP1_RS06365	COG0357	Ribosomal RNA small subunit methyltransferase G
STSP1_RS06370	COG4974	Belongs to the 'phage' integrase family
STSP1_RS06375	COG4452	Inner membrane protein CreD
STSP1_RS06380	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
STSP1_RS06385	COG0463	Glycosyl transferase, family 2
STSP1_RS06410	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
STSP1_RS06425	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
STSP1_RS06440	COG1120	ATPase activity
STSP1_RS06445	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
STSP1_RS06450	COG3494	Protein of unknown function (DUF1009)
STSP1_RS06455	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
STSP1_RS06460	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
STSP1_RS06465	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
STSP1_RS06475	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
STSP1_RS06495	COG1528	Iron-storage protein
STSP1_RS06500	COG2033	superoxide reductase activity
STSP1_RS06505	COG0426	domain, Protein
STSP1_RS06510	COG1592	Rubrerythrin
STSP1_RS06515	COG0735	belongs to the Fur family
STSP1_RS06540	COG0535	radical SAM domain protein
STSP1_RS06545	COG0612	Peptidase, M16
STSP1_RS06550	COG0612	Peptidase, M16
STSP1_RS06555	COG1196	nuclear chromosome segregation
STSP1_RS06690	COG3250	beta-galactosidase activity
STSP1_RS06695	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
STSP1_RS06700	COG1408	metallophosphoesterase
STSP1_RS06710	COG0531	amino acid
STSP1_RS06745	COG2361	Protein of unknown function DUF86
STSP1_RS06760	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
STSP1_RS06765	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
STSP1_RS06770	COG3250	beta-galactosidase activity
STSP1_RS06780	COG1609	Transcriptional regulator
STSP1_RS06780	COG2207	Transcriptional regulator
STSP1_RS06785	COG0800	Aldolase
STSP1_RS06800	COG3119	arylsulfatase activity
STSP1_RS06835	COG0733	neurotransmitter:sodium symporter activity
STSP1_RS06840	COG1181	Belongs to the D-alanine--D-alanine ligase family
STSP1_RS06855	COG0632	four-way junction helicase activity
STSP1_RS06860	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
STSP1_RS06865	COG0358	DNA primase activity
STSP1_RS07050	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
STSP1_RS07065	COG0653	protein targeting
STSP1_RS07070	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
STSP1_RS07110	COG1013	pyruvate-flavodoxin oxidoreductase activity
STSP1_RS07130	COG0860	N-Acetylmuramoyl-L-alanine amidase
STSP1_RS07160	COG0542	response to heat
STSP1_RS07170	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
STSP1_RS07215	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
STSP1_RS07235	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
STSP1_RS07240	COG1475	DNA binding
STSP1_RS07245	COG0116	Belongs to the methyltransferase superfamily
STSP1_RS07255	COG0492	ferredoxin-NADP+ reductase activity
STSP1_RS07270	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
STSP1_RS07280	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
STSP1_RS07285	COG3386	PFAM SMP-30 Gluconolaconase
STSP1_RS07290	COG0386	Belongs to the glutathione peroxidase family
STSP1_RS07300	COG1074	ATP-dependent DNA helicase activity
STSP1_RS07305	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
STSP1_RS07310	COG0307	riboflavin synthase, alpha
STSP1_RS07315	COG0105	UTP biosynthetic process
STSP1_RS07345	COG4956	integral membrane protein (PIN domain superfamily)
STSP1_RS07350	COG2088	sporulation resulting in formation of a cellular spore
STSP1_RS07355	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
STSP1_RS07415	COG0489	protein tyrosine kinase activity
STSP1_RS07450	COG1028	Short-chain dehydrogenase reductase Sdr
STSP1_RS07455	COG1088	dTDP-glucose 4,6-dehydratase activity
STSP1_RS07460	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
STSP1_RS07465	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
STSP1_RS07470	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
STSP1_RS07490	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
STSP1_RS07510	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
STSP1_RS07515	COG0823	Involved in the tonB-independent uptake of proteins
STSP1_RS07525	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
STSP1_RS07530	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
STSP1_RS07555	COG3119	arylsulfatase activity
STSP1_RS07560	COG3119	arylsulfatase activity
STSP1_RS07570	COG2207	Transcriptional regulator
STSP1_RS07570	COG1609	Transcriptional regulator
STSP1_RS07590	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
STSP1_RS07590	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
STSP1_RS07620	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
STSP1_RS07660	COG0564	pseudouridine synthase activity
STSP1_RS07680	COG2165	general secretion pathway protein
STSP1_RS07685	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
STSP1_RS07690	COG1132	(ABC) transporter
STSP1_RS07695	COG0101	tRNA pseudouridine synthase activity
STSP1_RS07700	COG0436	Aminotransferase
STSP1_RS07710	COG0515	serine threonine protein kinase
STSP1_RS07710	COG2815	serine threonine protein kinase
STSP1_RS07715	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
STSP1_RS07745	COG4974	Belongs to the 'phage' integrase family
STSP1_RS07750	COG0261	This protein binds to 23S rRNA in the presence of protein L20
STSP1_RS07755	COG0285	dihydrofolate synthase activity
STSP1_RS07765	COG1381	Involved in DNA repair and RecF pathway recombination
STSP1_RS07775	COG0352	thiamine-phosphate diphosphorylase activity
STSP1_RS07790	COG0828	Belongs to the bacterial ribosomal protein bS21 family
STSP1_RS07800	COG0069	glutamate synthase activity
STSP1_RS07800	COG0070	glutamate synthase
STSP1_RS07800	COG0067	glutamate synthase
STSP1_RS07815	COG0488	(ABC) transporter
STSP1_RS07835	COG0347	Belongs to the P(II) protein family
STSP1_RS07840	COG0004	ammonium transporteR
STSP1_RS07850	COG1136	(ABC) transporter
STSP1_RS07865	COG0698	ribose 5-phosphate isomerase
STSP1_RS07875	COG3119	arylsulfatase activity
STSP1_RS07900	COG3119	arylsulfatase activity
STSP1_RS07915	COG3119	arylsulfatase activity
STSP1_RS07920	COG0428	transporter
STSP1_RS07925	COG2195	Cleaves the N-terminal amino acid of tripeptides
STSP1_RS07935	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
STSP1_RS07985	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
STSP1_RS07995	COG0519	Catalyzes the synthesis of GMP from XMP
STSP1_RS07995	COG0518	GMP synthase (glutamine-hydrolyzing) activity
STSP1_RS08000	COG0516	GMP reductase activity
STSP1_RS08000	COG0517	IMP dehydrogenase activity
STSP1_RS08010	COG3177	Filamentation induced by cAMP protein fic
STSP1_RS08030	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
STSP1_RS08040	COG1086	Polysaccharide biosynthesis protein
STSP1_RS08065	COG0489	protein tyrosine kinase activity
STSP1_RS08070	COG1702	phosphate starvation-inducible protein PhoH
STSP1_RS08110	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
STSP1_RS08115	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
STSP1_RS08120	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
STSP1_RS08125	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
STSP1_RS08125	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
STSP1_RS08135	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
STSP1_RS08235	COG0154	amidase activity
STSP1_RS08270	COG0811	peptide transport
STSP1_RS08275	COG0811	peptide transport
STSP1_RS08280	COG0848	biopolymer transport protein
STSP1_RS08295	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
STSP1_RS08300	COG0531	amino acid
STSP1_RS08305	COG1715	Restriction endonuclease
STSP1_RS08315	COG4948	Mandelate Racemase Muconate Lactonizing
STSP1_RS08325	COG3119	arylsulfatase activity
STSP1_RS08330	COG3119	arylsulfatase activity
STSP1_RS08335	COG1501	Belongs to the glycosyl hydrolase 31 family
STSP1_RS08365	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
STSP1_RS08405	COG3119	arylsulfatase activity
STSP1_RS08430	COG3119	arylsulfatase activity
STSP1_RS08450	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
STSP1_RS08455	COG1774	PSP1 C-terminal conserved region
STSP1_RS08470	COG0037	tRNA processing
STSP1_RS08475	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
STSP1_RS08480	COG3119	arylsulfatase activity
STSP1_RS08485	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
STSP1_RS08490	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
STSP1_RS08495	COG0488	(ABC) transporter
STSP1_RS08510	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
STSP1_RS08515	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
STSP1_RS08525	COG2165	general secretion pathway protein
STSP1_RS08550	COG0297	glycogen (starch) synthase activity
STSP1_RS08560	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
STSP1_RS08575	COG0110	maltose O-acetyltransferase activity
STSP1_RS08585	COG0484	heat shock protein binding
STSP1_RS08590	COG0640	Transcriptional regulator
STSP1_RS08595	COG3119	arylsulfatase activity
STSP1_RS08610	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
STSP1_RS08615	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
STSP1_RS08695	COG0424	maF-like protein
STSP1_RS08710	COG0390	transport system, permease component
STSP1_RS08725	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
STSP1_RS08735	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
STSP1_RS08740	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
STSP1_RS08745	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
STSP1_RS08760	COG0275	rRNA processing
STSP1_RS08765	COG1652	LysM domain
STSP1_RS08805	COG5012	cobalamin binding
STSP1_RS08810	COG2848	UPF0210 protein
STSP1_RS08855	COG3119	arylsulfatase activity
STSP1_RS08885	COG1862	Preprotein translocase
STSP1_RS08890	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
STSP1_RS08905	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
STSP1_RS08910	COG5002	protein histidine kinase activity
STSP1_RS08910	COG0784	Response regulator, receiver
STSP1_RS08910	COG2198	Histidine kinase
STSP1_RS08920	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
STSP1_RS08925	COG0129	dihydroxy-acid dehydratase activity
STSP1_RS08940	COG1040	competence protein
STSP1_RS08955	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
STSP1_RS08960	COG1960	acyl-CoA dehydrogenase activity
STSP1_RS08965	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
STSP1_RS08970	COG2086	electron transfer activity
STSP1_RS08995	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
STSP1_RS09005	COG0557	exoribonuclease II activity
STSP1_RS09015	COG0768	penicillin binding
STSP1_RS09030	COG0195	Participates in both transcription termination and antitermination
STSP1_RS09035	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
STSP1_RS09040	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
STSP1_RS09055	COG2382	esterase
STSP1_RS09075	COG1538	Outer membrane efflux protein
STSP1_RS09085	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
STSP1_RS09100	COG1217	gtp-binding protein TYPA
STSP1_RS09115	COG0574	Belongs to the PEP-utilizing enzyme family
STSP1_RS09115	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
STSP1_RS09145	COG3250	beta-galactosidase activity
STSP1_RS09155	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
STSP1_RS09160	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
STSP1_RS09165	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
STSP1_RS09215	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
STSP1_RS09220	COG0018	arginyl-trna synthetase
STSP1_RS09230	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
STSP1_RS09235	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
STSP1_RS09240	COG0142	geranyltranstransferase activity
STSP1_RS09245	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
STSP1_RS09255	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
STSP1_RS09260	COG0658	competence protein
STSP1_RS09260	COG2333	competence protein COMEC
STSP1_RS09265	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
STSP1_RS09275	COG0322	excinuclease ABC activity
STSP1_RS09290	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
STSP1_RS09315	COG1605	Chorismate mutase
STSP1_RS09315	COG0077	Prephenate dehydratase
STSP1_RS09330	COG1561	YicC-like family, N-terminal region
STSP1_RS09340	COG1758	RNA polymerase activity
STSP1_RS09345	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
STSP1_RS09350	COG0793	Belongs to the peptidase S41A family
STSP1_RS09360	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
STSP1_RS09365	COG3119	arylsulfatase activity
STSP1_RS09370	COG3119	arylsulfatase activity
STSP1_RS09375	COG3119	arylsulfatase activity
STSP1_RS09385	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
STSP1_RS09395	COG2183	response to ionizing radiation
STSP1_RS09410	COG0165	Argininosuccinate lyase
STSP1_RS09430	COG0483	inositol monophosphate 1-phosphatase activity
STSP1_RS09450	COG1966	Carbon starvation protein
STSP1_RS09520	COG1322	Protein conserved in bacteria
STSP1_RS09525	COG3119	arylsulfatase activity
STSP1_RS09555	COG1509	lysine 2,3-aminomutase activity
STSP1_RS09565	COG0525	valine-tRNA ligase activity
STSP1_RS09585	COG1137	ATPase activity
STSP1_RS09590	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
STSP1_RS09600	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
STSP1_RS09610	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
STSP1_RS09615	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
STSP1_RS09640	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
STSP1_RS09670	COG0667	Aldo Keto reductase
STSP1_RS09680	COG1056	cytidyltransferase-related domain
STSP1_RS09680	COG1051	belongs to the nudix hydrolase family
STSP1_RS09685	COG3706	GGDEF domain
STSP1_RS09695	COG0446	pyridine nucleotide-disulphide oxidoreductase
STSP1_RS09705	COG2204	response regulator
STSP1_RS09730	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
STSP1_RS09745	COG0811	peptide transport
STSP1_RS09755	COG0459	protein refolding
STSP1_RS09765	COG0459	protein refolding
STSP1_RS09770	COG0484	heat shock protein binding
STSP1_RS09785	COG3119	arylsulfatase activity
STSP1_RS09790	COG1480	7TM receptor with intracellular HD hydrolase
STSP1_RS09795	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
STSP1_RS09800	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
STSP1_RS09805	COG1971	Probably functions as a manganese efflux pump
STSP1_RS09825	COG2255	four-way junction helicase activity
STSP1_RS09850	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
STSP1_RS09855	COG1459	type II secretion system
STSP1_RS09905	COG0784	Response regulator, receiver
STSP1_RS09910	COG0006	proline dipeptidase activity
STSP1_RS09945	COG3250	beta-galactosidase activity
STSP1_RS09970	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
STSP1_RS09980	COG0500	methyltransferase
STSP1_RS09995	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
STSP1_RS10010	COG0072	phenylalanine-tRNA ligase activity
STSP1_RS10020	COG0133	tryptophan synthase activity
STSP1_RS10040	COG0693	protein deglycase activity
STSP1_RS10085	COG1609	Transcriptional regulator
STSP1_RS10085	COG2207	Transcriptional regulator
STSP1_RS10095	COG1595	DNA-templated transcription, initiation
STSP1_RS10105	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
STSP1_RS10115	COG0710	3-dehydroquinate dehydratase activity
STSP1_RS10115	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
STSP1_RS10125	COG0138	bifunctional purine biosynthesis protein purh
STSP1_RS10145	COG3046	protein related to deoxyribodipyrimidine photolyase
STSP1_RS10150	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
STSP1_RS10155	COG0423	glycine-tRNA ligase activity
STSP1_RS10160	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
STSP1_RS10165	COG0227	Belongs to the bacterial ribosomal protein bL28 family
STSP1_RS10205	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
STSP1_RS10215	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
STSP1_RS10255	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
STSP1_RS10255	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
STSP1_RS10260	COG0825	malonyl-CoA metabolic process
STSP1_RS10265	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
STSP1_RS10310	COG0439	Biotin carboxylase
STSP1_RS10325	COG1058	Belongs to the CinA family
STSP1_RS10325	COG1546	Belongs to the CinA family
STSP1_RS10330	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
STSP1_RS10340	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
STSP1_RS10345	COG1459	type II secretion system
STSP1_RS10390	COG2815	serine threonine protein kinase
STSP1_RS10390	COG0515	serine threonine protein kinase
STSP1_RS10445	COG0051	transcription antitermination factor activity, RNA binding
STSP1_RS10450	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
STSP1_RS10455	COG0088	Forms part of the polypeptide exit tunnel
STSP1_RS10460	COG0089	rRNA binding
STSP1_RS10465	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
STSP1_RS10470	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
STSP1_RS10475	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
STSP1_RS10485	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
STSP1_RS10500	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
STSP1_RS10505	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
STSP1_RS10515	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
STSP1_RS10520	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
STSP1_RS10525	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
STSP1_RS10530	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
STSP1_RS10540	COG0200	Binds to the 23S rRNA
STSP1_RS10545	COG0201	protein transport
STSP1_RS10550	COG0563	adenylate kinase activity
STSP1_RS10555	COG0024	Methionine aminopeptidase
STSP1_RS10560	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
STSP1_RS10565	COG0257	Belongs to the bacterial ribosomal protein bL36 family
STSP1_RS10570	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
STSP1_RS10575	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
STSP1_RS10580	COG0202	RNA polymerase activity
STSP1_RS10585	COG0203	ribosomal protein L17
STSP1_RS10590	COG0537	adenosine 5'-monophosphoramidase activity
STSP1_RS10620	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
STSP1_RS10625	COG2165	general secretion pathway protein
STSP1_RS10630	COG3408	Glycogen debranching enzyme
STSP1_RS10630	COG3119	arylsulfatase activity
STSP1_RS10635	COG1262	PFAM Formylglycine-generating sulfatase enzyme
STSP1_RS10635	COG0515	serine threonine protein kinase
STSP1_RS10640	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
STSP1_RS10670	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
STSP1_RS10675	COG3250	beta-galactosidase activity
STSP1_RS10770	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
STSP1_RS10795	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
STSP1_RS10810	COG1136	(ABC) transporter
STSP1_RS10815	COG0577	efflux transmembrane transporter activity
STSP1_RS10815	COG1136	(ABC) transporter
STSP1_RS10830	COG1704	LemA family
STSP1_RS10835	COG3549	Plasmid maintenance system killer
STSP1_RS10845	COG0501	Belongs to the peptidase M48B family
STSP1_RS10875	COG0564	pseudouridine synthase activity
STSP1_RS10885	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
STSP1_RS10900	COG1185	polyribonucleotide nucleotidyltransferase activity
STSP1_RS10905	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
STSP1_RS10925	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
STSP1_RS10930	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
STSP1_RS10935	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
STSP1_RS10945	COG0617	tRNA 3'-terminal CCA addition
STSP1_RS10955	COG0483	inositol monophosphate 1-phosphatase activity
STSP1_RS10970	COG3250	beta-galactosidase activity
STSP1_RS10975	COG3077	Addiction module antitoxin, RelB DinJ family
STSP1_RS10980	COG3041	Addiction module toxin RelE StbE family
STSP1_RS10990	COG3481	metal-dependent phosphohydrolase, HD sub domain
STSP1_RS11005	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
STSP1_RS11010	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
STSP1_RS11015	COG0268	Binds directly to 16S ribosomal RNA
STSP1_RS11020	COG0211	Belongs to the bacterial ribosomal protein bL27 family
STSP1_RS11030	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
STSP1_RS11070	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
STSP1_RS11095	COG0328	RNA-DNA hybrid ribonuclease activity
STSP1_RS11100	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
STSP1_RS11105	COG3250	beta-galactosidase activity
STSP1_RS11130	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
STSP1_RS11135	COG3119	arylsulfatase activity
STSP1_RS11145	COG2885	chlorophyll binding
STSP1_RS11165	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
STSP1_RS11175	COG1472	Belongs to the glycosyl hydrolase 3 family
STSP1_RS11185	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
STSP1_RS11190	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
STSP1_RS11195	COG0237	dephospho-CoA kinase activity
STSP1_RS11250	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
STSP1_RS11255	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
STSP1_RS11260	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
STSP1_RS11275	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
STSP1_RS11280	COG1136	(ABC) transporter
STSP1_RS11285	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
STSP1_RS11290	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
STSP1_RS11300	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
STSP1_RS11305	COG0802	atpase or kinase
STSP1_RS11315	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
STSP1_RS11320	COG0442	prolyl-tRNA aminoacylation
STSP1_RS11330	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
STSP1_RS11335	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
STSP1_RS11385	COG1459	type II secretion system
STSP1_RS11425	COG0556	nucleotide-excision repair
STSP1_RS11440	COG3119	arylsulfatase activity
STSP1_RS11460	COG4806	L-rhamnose isomerase
STSP1_RS11465	COG0235	Class ii aldolase
STSP1_RS11485	COG3250	beta-galactosidase activity
STSP1_RS11490	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
STSP1_RS11495	COG2890	protein-(glutamine-N5) methyltransferase activity
STSP1_RS11515	COG2814	Major facilitator Superfamily
STSP1_RS11515	COG0477	Major facilitator Superfamily
STSP1_RS11535	COG3119	arylsulfatase activity
STSP1_RS11545	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
STSP1_RS11550	COG0459	protein refolding
STSP1_RS11580	COG1136	(ABC) transporter
STSP1_RS11585	COG0706	membrane insertase activity
STSP1_RS11595	COG0404	The glycine cleavage system catalyzes the degradation of glycine
STSP1_RS11600	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
STSP1_RS11620	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
STSP1_RS11655	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
STSP1_RS11670	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
STSP1_RS11670	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
STSP1_RS11680	COG0569	domain protein
STSP1_RS11710	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
STSP1_RS11725	COG0436	Aminotransferase
STSP1_RS11730	COG0534	Mate efflux family protein
STSP1_RS11740	COG1519	Transferase
STSP1_RS11745	COG0641	radical SAM
STSP1_RS11755	COG0436	Aminotransferase
STSP1_RS11775	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
STSP1_RS11780	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
STSP1_RS11785	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
STSP1_RS11795	COG0205	6-phosphofructokinase activity
STSP1_RS11800	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
STSP1_RS11805	COG2239	Acts as a magnesium transporter
STSP1_RS11810	COG1082	Xylose isomerase domain protein TIM barrel
STSP1_RS11820	COG3507	Belongs to the glycosyl hydrolase 43 family
STSP1_RS11855	COG0124	histidyl-tRNA synthetase
STSP1_RS11865	COG1192	Involved in chromosome partitioning
STSP1_RS11870	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
STSP1_RS11880	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
STSP1_RS11890	COG0505	Belongs to the CarA family
STSP1_RS11895	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
STSP1_RS11905	COG0438	transferase activity, transferring glycosyl groups
STSP1_RS11915	COG0594	ribonuclease P activity
STSP1_RS11920	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
STSP1_RS11920	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
STSP1_RS11920	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
STSP1_RS11960	COG0489	protein tyrosine kinase activity
STSP1_RS11970	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
STSP1_RS11980	COG0826	peptidase U32
STSP1_RS11995	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
STSP1_RS12005	COG1968	undecaprenyl-diphosphatase activity
STSP1_RS12015	COG3119	arylsulfatase activity
STSP1_RS12030	COG0071	Belongs to the small heat shock protein (HSP20) family
STSP1_RS12035	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
STSP1_RS12045	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
STSP1_RS12050	COG0151	Belongs to the GarS family
STSP1_RS12075	COG0463	Glycosyl transferase, family 2
STSP1_RS12090	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
STSP1_RS12095	COG0540	Belongs to the ATCase OTCase family
STSP1_RS12100	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
STSP1_RS12105	COG0571	ribonuclease III activity
STSP1_RS12110	COG1902	pentaerythritol trinitrate reductase activity
STSP1_RS12120	COG4585	Histidine kinase
STSP1_RS12140	COG4536	flavin adenine dinucleotide binding
STSP1_RS12150	COG0745	RESPONSE REGULATOR receiver
STSP1_RS12155	COG0528	UMP kinase activity
STSP1_RS12160	COG0233	cytoplasmic translational termination
STSP1_RS12170	COG1295	ribonuclease BN
STSP1_RS12175	COG0772	Belongs to the SEDS family
STSP1_RS12180	COG2155	Conserved Protein
STSP1_RS12185	COG2207	Transcriptional regulator
STSP1_RS12190	COG2207	Transcriptional regulator
STSP1_RS12190	COG1609	Transcriptional regulator
STSP1_RS12205	COG2814	Major facilitator Superfamily
STSP1_RS12210	COG2814	Major facilitator Superfamily
STSP1_RS12225	COG3345	alpha-galactosidase
STSP1_RS12250	COG3119	arylsulfatase activity
STSP1_RS12260	COG0084	hydrolase, TatD family'
STSP1_RS12265	COG0142	geranyltranstransferase activity
STSP1_RS12270	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
STSP1_RS12290	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
STSP1_RS12295	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
STSP1_RS12295	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons