locus-tag	class	description
C5523_RS00010	COG0592	DNA-directed DNA polymerase activity
C5523_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C5523_RS00025	COG0583	DNA-binding transcription factor activity
C5523_RS00030	COG0604	alcohol dehydrogenase
C5523_RS00030	COG1028	Short-chain dehydrogenase reductase Sdr
C5523_RS00030	COG3321	synthase
C5523_RS00035	COG0561	phosphatase activity
C5523_RS00045	COG2186	Transcriptional regulator
C5523_RS00050	COG3734	2-keto-3-deoxy-galactonokinase
C5523_RS00055	COG0800	Aldolase
C5523_RS00060	COG4948	Mandelate Racemase Muconate Lactonizing
C5523_RS00065	COG2271	Major facilitator Superfamily
C5523_RS00070	COG0823	Involved in the tonB-independent uptake of proteins
C5523_RS00075	COG5645	(Lipo)protein
C5523_RS00095	COG2188	Transcriptional regulator
C5523_RS00110	COG2149	membrane
C5523_RS00130	COG2814	Major facilitator Superfamily
C5523_RS00145	COG3177	Filamentation induced by cAMP protein fic
C5523_RS00155	COG0028	Belongs to the TPP enzyme family
C5523_RS00160	COG0440	acetolactate synthase activity
C5523_RS00165	COG1349	DNA-binding transcription factor activity
C5523_RS00175	COG0738	Major facilitator superfamily
C5523_RS00200	COG4580	involved in the transport of maltose and maltodextrins
C5523_RS00205	COG1447	Phosphotransferase system cellobiose-specific component IIA
C5523_RS00210	COG2723	6-phospho-beta-galactosidase activity
C5523_RS00215	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C5523_RS00230	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
C5523_RS00245	COG0179	Fumarylacetoacetate (FAA) hydrolase
C5523_RS00250	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
C5523_RS00265	COG0778	Nitroreductase
C5523_RS00300	COG0583	DNA-binding transcription factor activity
C5523_RS00305	COG1028	Short-chain dehydrogenase reductase Sdr
C5523_RS00310	COG0765	amino acid transport
C5523_RS00315	COG1126	abc transporter atp-binding protein
C5523_RS00320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5523_RS00340	COG2610	gluconate transmembrane transporter activity
C5523_RS00345	COG0129	dihydroxy-acid dehydratase activity
C5523_RS00350	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C5523_RS00355	COG1414	Transcriptional regulator
C5523_RS00415	COG3711	transcriptional antiterminator
C5523_RS00420	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C5523_RS00420	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C5523_RS00420	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C5523_RS00425	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C5523_RS00430	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C5523_RS00430	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C5523_RS00440	COG0191	fructose-bisphosphate aldolase activity
C5523_RS00445	COG1940	carbohydrate kinase activity
C5523_RS00455	COG2982	Protein involved in outer membrane biogenesis
C5523_RS00460	COG2233	PERMEase
C5523_RS00470	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C5523_RS00475	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C5523_RS00480	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C5523_RS00500	COG5434	Belongs to the glycosyl hydrolase 28 family
C5523_RS00505	COG1561	YicC-like family, N-terminal region
C5523_RS00535	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C5523_RS00545	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C5523_RS00550	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C5523_RS00555	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C5523_RS00560	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C5523_RS00570	COG1519	Transferase
C5523_RS00575	COG1216	Glycosyl transferase, family 2
C5523_RS00580	COG0438	transferase activity, transferring glycosyl groups
C5523_RS00590	COG0859	PFAM glycosyl transferase family 9
C5523_RS00610	COG0859	PFAM glycosyl transferase family 9
C5523_RS00620	COG0859	PFAM glycosyl transferase family 9
C5523_RS00630	COG0156	8-amino-7-oxononanoate synthase activity
C5523_RS00645	COG2861	carbohydrate metabolic process
C5523_RS00650	COG4942	peptidase
C5523_RS00655	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C5523_RS00660	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C5523_RS00665	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C5523_RS00685	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C5523_RS00695	COG2186	Transcriptional regulator
C5523_RS00710	COG3722	fumarate hydratase activity
C5523_RS00725	COG0625	glutathione transferase activity
C5523_RS00735	COG3276	selenocysteine insertion sequence binding
C5523_RS00740	COG0513	Belongs to the DEAD box helicase family
C5523_RS00750	COG2211	Major facilitator Superfamily
C5523_RS00760	COG0235	Class ii aldolase
C5523_RS00765	COG3623	hexulose-6-phosphate isomerase
C5523_RS00770	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
C5523_RS00775	COG1070	Carbohydrate kinase
C5523_RS00790	COG2731	YhcH YjgK YiaL family protein
C5523_RS00810	COG1172	Belongs to the binding-protein-dependent transport system permease family
C5523_RS00815	COG1129	ABC transporter
C5523_RS00820	COG1414	Transcriptional regulator
C5523_RS00825	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C5523_RS00830	COG3977	Valine--pyruvate aminotransferase
C5523_RS00835	COG0366	Alpha amylase catalytic
C5523_RS00845	COG2992	FlgJ-related protein
C5523_RS00850	COG2207	Transcriptional regulator
C5523_RS00850	COG1609	Transcriptional regulator
C5523_RS00855	COG4214	carbohydrate transport
C5523_RS00865	COG4213	ABC transporter substrate-binding protein
C5523_RS00870	COG2115	Belongs to the xylose isomerase family
C5523_RS00875	COG1070	Carbohydrate kinase
C5523_RS00890	COG4682	membrane
C5523_RS00895	COG3274	enterobacterial common antigen metabolic process
C5523_RS00930	COG0488	(ABC) transporter
C5523_RS00935	COG2944	sequence-specific DNA binding
C5523_RS00955	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C5523_RS00965	COG1609	Transcriptional regulator
C5523_RS00970	COG0243	molybdopterin cofactor binding
C5523_RS00975	COG0456	acetyltransferase
C5523_RS00980	COG2818	Glycosylase
C5523_RS00985	COG5571	outer membrane autotransporter
C5523_RS00990	COG2223	nitrite transmembrane transporter activity
C5523_RS00995	COG1764	response to oxidative stress
C5523_RS01000	COG2194	sulfuric ester hydrolase activity
C5523_RS01025	COG0747	negative chemotaxis
C5523_RS01030	COG0601	transmembrane transport
C5523_RS01035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C5523_RS01040	COG0444	Belongs to the ABC transporter superfamily
C5523_RS01045	COG4608	Belongs to the ABC transporter superfamily
C5523_RS01060	COG1304	FMN binding
C5523_RS01065	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C5523_RS01070	COG1335	isochorismatase
C5523_RS01080	COG0583	DNA-binding transcription factor activity
C5523_RS01090	COG1192	Involved in chromosome partitioning
C5523_RS01105	COG0457	Tetratricopeptide repeat
C5523_RS01120	COG2194	sulfuric ester hydrolase activity
C5523_RS01140	COG1192	Involved in chromosome partitioning
C5523_RS01155	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
C5523_RS01160	COG0457	Tetratricopeptide repeat
C5523_RS01160	COG3118	belongs to the thioredoxin family
C5523_RS01165	COG2199	diguanylate cyclase activity
C5523_RS01165	COG2200	EAL domain
C5523_RS01175	COG1301	dicarboxylic acid transport
C5523_RS01190	COG2200	EAL domain
C5523_RS01195	COG2982	Protein involved in outer membrane biogenesis
C5523_RS01200	COG0477	Major facilitator Superfamily
C5523_RS01205	COG1295	ribonuclease BN
C5523_RS01210	COG0583	DNA-binding transcription factor activity
C5523_RS01215	COG1028	Short-chain dehydrogenase reductase Sdr
C5523_RS01220	COG3111	PFAM Bacterial OB fold (BOF) protein
C5523_RS01225	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C5523_RS01240	COG0583	DNA-binding transcription factor activity
C5523_RS01255	COG2957	Belongs to the agmatine deiminase family
C5523_RS01285	COG0519	Catalyzes the synthesis of GMP from XMP
C5523_RS01285	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C5523_RS01290	COG0456	acetyltransferase
C5523_RS01290	COG1846	Transcriptional regulator
C5523_RS01295	COG0840	transmembrane signaling receptor activity
C5523_RS01305	COG1438	arginine binding
C5523_RS01315	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C5523_RS01325	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
C5523_RS01330	COG0671	phosphoesterase, PA-phosphatase related
C5523_RS01350	COG0589	response to stress
C5523_RS01360	COG0306	phosphate transporter
C5523_RS01365	COG2081	HI0933 family
C5523_RS01385	COG2200	EAL domain
C5523_RS01390	COG0789	Transcriptional regulator
C5523_RS01430	COG0024	Methionine aminopeptidase
C5523_RS01445	COG1538	Outer membrane efflux protein
C5523_RS01450	COG1566	PFAM secretion protein HlyD family protein
C5523_RS01455	COG2814	Major facilitator Superfamily
C5523_RS01465	COG3265	gluconokinase activity
C5523_RS01470	COG1063	alcohol dehydrogenase
C5523_RS01475	COG1028	Short-chain dehydrogenase reductase Sdr
C5523_RS01480	COG2610	gluconate transmembrane transporter activity
C5523_RS01485	COG1609	Transcriptional regulator
C5523_RS01490	COG0840	transmembrane signaling receptor activity
C5523_RS01500	COG3964	amidohydrolase
C5523_RS01505	COG0471	metal ion transport
C5523_RS01510	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C5523_RS01515	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C5523_RS01520	COG0583	DNA-binding transcription factor activity
C5523_RS01530	COG1028	Short-chain dehydrogenase reductase Sdr
C5523_RS01535	COG0371	Dehydrogenase
C5523_RS01555	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C5523_RS01560	COG0601	transmembrane transport
C5523_RS01565	COG0747	negative chemotaxis
C5523_RS01575	COG3479	Phenolic acid decarboxylase
C5523_RS01580	COG0628	permease
C5523_RS01585	COG0477	Major facilitator Superfamily
C5523_RS01595	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
C5523_RS01605	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C5523_RS01620	COG2217	Heavy metal translocating P-type atpase
C5523_RS01625	COG3714	YhhN family
C5523_RS01630	COG3776	membrane
C5523_RS01635	COG0742	ribosomal rna small subunit methyltransferase
C5523_RS01640	COG0552	protein localization to endoplasmic reticulum
C5523_RS01645	COG2884	Cell division ATP-binding protein ftsE
C5523_RS01650	COG2177	Part of the ABC transporter FtsEX involved in
C5523_RS01655	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C5523_RS01665	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C5523_RS01680	COG0683	leucine binding
C5523_RS01695	COG0411	ABC transporter
C5523_RS01700	COG0410	ABC transporter
C5523_RS01725	COG0584	glycerophosphoryl diester phosphodiesterase
C5523_RS01735	COG0405	Gamma-glutamyltransferase
C5523_RS01740	COG1247	-acetyltransferase
C5523_RS01750	COG0673	inositol 2-dehydrogenase activity
C5523_RS01755	COG1741	Belongs to the pirin family
C5523_RS01760	COG1609	Transcriptional regulator
C5523_RS01765	COG3265	gluconokinase activity
C5523_RS01770	COG2610	gluconate transmembrane transporter activity
C5523_RS01775	COG2095	MarC family integral membrane protein
C5523_RS01780	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C5523_RS01790	COG1523	belongs to the glycosyl hydrolase 13 family
C5523_RS01805	COG0058	SHG alpha-glucan phosphorylase activity
C5523_RS01815	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C5523_RS01820	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C5523_RS01830	COG1349	DNA-binding transcription factor activity
C5523_RS01835	COG2909	trisaccharide binding
C5523_RS01840	COG0058	SHG alpha-glucan phosphorylase activity
C5523_RS01845	COG1640	4-alpha-glucanotransferase
C5523_RS01850	COG2610	gluconate transmembrane transporter activity
C5523_RS01885	COG1918	ferrous iron import across plasma membrane
C5523_RS01890	COG2183	response to ionizing radiation
C5523_RS01895	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C5523_RS01920	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C5523_RS01925	COG1011	Hydrolase
C5523_RS01935	COG0494	nUDIX hydrolase
C5523_RS01940	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
C5523_RS01945	COG4972	Pilus assembly protein
C5523_RS01950	COG3166	PFAM Fimbrial assembly family protein
C5523_RS01965	COG4796	Type ii and iii secretion system protein
C5523_RS01975	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C5523_RS01985	COG3266	domain, Protein
C5523_RS01990	COG0338	D12 class N6 adenine-specific DNA methyltransferase
C5523_RS01995	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C5523_RS02005	COG0180	Tryptophanyl-tRNA synthetase
C5523_RS02010	COG2188	Transcriptional regulator
C5523_RS02020	COG1082	Xylose isomerase domain protein TIM barrel
C5523_RS02025	COG2222	sugar isomerase
C5523_RS02030	COG0531	amino acid
C5523_RS02050	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C5523_RS02055	COG0402	S-adenosylhomocysteine deaminase activity
C5523_RS02075	COG0512	Glutamine amidotransferase of anthranilate synthase
C5523_RS02080	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C5523_RS02085	COG1289	transmembrane transporter activity
C5523_RS02095	COG1765	OsmC-like protein
C5523_RS02100	COG3954	Phosphoribulokinase
C5523_RS02105	COG3089	Belongs to the UPF0270 family
C5523_RS02110	COG0429	hydrolase of the alpha beta-hydrolase fold
C5523_RS02120	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C5523_RS02155	COG0679	Auxin Efflux Carrier
C5523_RS02165	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C5523_RS02175	COG0488	(ABC) transporter
C5523_RS02180	COG2249	NAD(P)H dehydrogenase (quinone) activity
C5523_RS02185	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C5523_RS02185	COG0475	glutathione-regulated potassium exporter activity
C5523_RS02190	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
C5523_RS02195	COG1047	Peptidyl-prolyl cis-trans
C5523_RS02205	COG0545	Peptidyl-prolyl cis-trans isomerase
C5523_RS02210	COG2964	Protein conserved in bacteria
C5523_RS02225	COG2168	tRNA wobble position uridine thiolation
C5523_RS02275	COG0051	transcription antitermination factor activity, RNA binding
C5523_RS02285	COG0088	Forms part of the polypeptide exit tunnel
C5523_RS02300	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C5523_RS02315	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C5523_RS02320	COG0255	Belongs to the universal ribosomal protein uL29 family
C5523_RS02330	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C5523_RS02365	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C5523_RS02375	COG0200	Binds to the 23S rRNA
C5523_RS02380	COG0201	protein transport
C5523_RS02410	COG0203	ribosomal protein L17
C5523_RS02420	COG0789	Transcriptional regulator
C5523_RS02425	COG3036	rescue of stalled ribosome
C5523_RS02455	COG0758	DNA mediated transformation
C5523_RS02465	COG0551	DNA topoisomerase type I activity
C5523_RS02485	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C5523_RS02525	COG1126	abc transporter atp-binding protein
C5523_RS02530	COG0765	amino acid transport
C5523_RS02535	COG4597	amino acid ABC transporter
C5523_RS02540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5523_RS02650	COG1802	Transcriptional regulator
C5523_RS02650	COG4626	Terminase
C5523_RS02680	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C5523_RS02690	COG4145	pantothenate transmembrane transporter activity
C5523_RS02695	COG3924	membrane
C5523_RS02700	COG0439	Biotin carboxylase
C5523_RS02705	COG0511	ligase activity, forming carbon-carbon bonds
C5523_RS02720	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
C5523_RS02730	COG2199	diguanylate cyclase activity
C5523_RS02730	COG2200	EAL domain
C5523_RS02740	COG1077	Cell shape determining protein MreB Mrl
C5523_RS02745	COG1792	Involved in formation and maintenance of cell shape
C5523_RS02750	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
C5523_RS02765	COG3164	Protein of unknown function
C5523_RS02770	COG0312	modulator of DNA gyrase
C5523_RS02775	COG0583	DNA-binding transcription factor activity
C5523_RS02800	COG2732	(Barnase) inhibitor
C5523_RS02825	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C5523_RS02830	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C5523_RS02835	COG3105	Protein conserved in bacteria
C5523_RS02840	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C5523_RS02855	COG0625	glutathione transferase activity
C5523_RS02860	COG2969	positive regulation of protein catabolic process
C5523_RS02870	COG1028	Short-chain dehydrogenase reductase Sdr
C5523_RS02875	COG0673	inositol 2-dehydrogenase activity
C5523_RS02885	COG2271	Major facilitator Superfamily
C5523_RS02890	COG1053	succinate dehydrogenase
C5523_RS02920	COG2731	YhcH YjgK YiaL family protein
C5523_RS02925	COG0493	'glutamate synthase
C5523_RS02930	COG0067	glutamate synthase
C5523_RS02930	COG0070	glutamate synthase
C5523_RS02930	COG0069	glutamate synthase activity
C5523_RS02940	COG1242	4 iron, 4 sulfur cluster binding
C5523_RS02945	COG2198	Histidine kinase
C5523_RS02945	COG0784	Response regulator, receiver
C5523_RS02945	COG5002	protein histidine kinase activity
C5523_RS02950	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
C5523_RS02960	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C5523_RS02965	COG1660	Displays ATPase and GTPase activities
C5523_RS02985	COG1137	ATPase activity
C5523_RS02990	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
C5523_RS02995	COG3117	lipopolysaccharide transmembrane transporter activity
C5523_RS03000	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
C5523_RS03010	COG0530	calcium, potassium:sodium antiporter activity
C5523_RS03015	COG1127	ABC transporter
C5523_RS03020	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C5523_RS03025	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C5523_RS03030	COG2854	intermembrane phospholipid transfer
C5523_RS03035	COG3113	response to antibiotic
C5523_RS03040	COG5007	Belongs to the BolA IbaG family
C5523_RS03050	COG3423	Transcriptional regulator
C5523_RS03055	COG0142	geranyltranstransferase activity
C5523_RS03060	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C5523_RS03070	COG0697	spore germination
C5523_RS03080	COG2027	D-alanyl-D-alanine carboxypeptidase
C5523_RS03090	COG1534	Rna-binding protein
C5523_RS03105	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C5523_RS03110	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C5523_RS03115	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C5523_RS03140	COG0195	Participates in both transcription termination and antitermination
C5523_RS03185	COG0513	Belongs to the DEAD box helicase family
C5523_RS03190	COG0814	amino acid
C5523_RS03195	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C5523_RS03200	COG0826	peptidase U32
C5523_RS03205	COG0826	peptidase U32
C5523_RS03210	COG3154	lipid carrier protein
C5523_RS03215	COG3153	acetyltransferase
C5523_RS03220	COG2827	Endonuclease containing a URI domain
C5523_RS03230	COG0693	protein deglycase activity
C5523_RS03235	COG0702	epimerase
C5523_RS03240	COG0701	Predicted permease
C5523_RS03245	COG2823	Periplasmic or secreted lipoprotein
C5523_RS03260	COG3107	peptidoglycan biosynthetic process
C5523_RS03265	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C5523_RS03275	COG1063	alcohol dehydrogenase
C5523_RS03280	COG3775	system Galactitol-specific IIC component
C5523_RS03285	COG3414	Phosphotransferase system galactitol-specific IIB component
C5523_RS03290	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C5523_RS03305	COG2721	sulfolactate sulfo-lyase activity
C5523_RS03310	COG2271	Major facilitator Superfamily
C5523_RS03320	COG2084	Dehydrogenase
C5523_RS03325	COG1929	Belongs to the glycerate kinase type-1 family
C5523_RS03335	COG4319	ketosteroid isomerase
C5523_RS03340	COG1741	Belongs to the pirin family
C5523_RS03345	COG0583	DNA-binding transcription factor activity
C5523_RS03350	COG3152	Membrane
C5523_RS03355	COG0435	Glutathione S-transferase
C5523_RS03360	COG2259	Doxx family
C5523_RS03370	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
C5523_RS03375	COG4575	ribosome binding
C5523_RS03380	COG1422	Protein of unknown function (DUF1090)
C5523_RS03390	COG0586	Pfam SNARE associated Golgi protein
C5523_RS03395	COG2186	Transcriptional regulator
C5523_RS03400	COG2271	Major facilitator Superfamily
C5523_RS03410	COG2721	sulfolactate sulfo-lyase activity
C5523_RS03425	COG0861	Integral membrane protein TerC family
C5523_RS03435	COG0673	inositol 2-dehydrogenase activity
C5523_RS03440	COG0436	Aminotransferase
C5523_RS03445	COG1464	Belongs to the NlpA lipoprotein family
C5523_RS03455	COG2011	ABC-type metal ion transport system permease component
C5523_RS03460	COG1854	S-ribosylhomocysteine lyase activity
C5523_RS03480	COG1448	Aminotransferase
C5523_RS03490	COG1522	sequence-specific DNA binding
C5523_RS03505	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C5523_RS03510	COG1451	nucleotide metabolic process
C5523_RS03520	COG0446	pyridine nucleotide-disulphide oxidoreductase
C5523_RS03520	COG1902	pentaerythritol trinitrate reductase activity
C5523_RS03525	COG1070	Carbohydrate kinase
C5523_RS03530	COG2390	Transcriptional regulator
C5523_RS03535	COG1129	ABC transporter
C5523_RS03540	COG1172	Belongs to the binding-protein-dependent transport system permease family
C5523_RS03550	COG1879	ABC-type sugar transport system periplasmic component
C5523_RS03555	COG1830	Aldolase
C5523_RS03560	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
C5523_RS03570	COG0840	transmembrane signaling receptor activity
C5523_RS03575	COG0840	transmembrane signaling receptor activity
C5523_RS03580	COG1695	Transcriptional regulator
C5523_RS03585	COG2375	cellular response to nickel ion
C5523_RS03600	COG1609	Transcriptional regulator
C5523_RS03705	COG0740	serine-type endopeptidase activity
C5523_RS03765	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C5523_RS03765	COG0517	IMP dehydrogenase activity
C5523_RS03775	COG0358	DNA primase activity
C5523_RS03780	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C5523_RS03795	COG0028	Belongs to the TPP enzyme family
C5523_RS03805	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C5523_RS03815	COG0617	tRNA 3'-terminal CCA addition
C5523_RS03820	COG4991	sh3 domain protein
C5523_RS03825	COG3025	triphosphatase activity
C5523_RS03845	COG2268	Band 7 protein
C5523_RS03850	COG1585	Membrane protein implicated in regulation of membrane protease activity
C5523_RS03875	COG3384	dioxygenase
C5523_RS03880	COG0754	glutathionylspermidine amidase activity
C5523_RS03890	COG1538	Outer membrane efflux protein
C5523_RS03895	COG0494	nUDIX hydrolase
C5523_RS03900	COG3151	Protein conserved in bacteria
C5523_RS03905	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C5523_RS03910	COG3150	esterase
C5523_RS03915	COG0187	DNA topoisomerase II activity
C5523_RS03925	COG1904	glucuronate isomerase
C5523_RS03930	COG1312	Catalyzes the dehydration of D-mannonate
C5523_RS03935	COG3615	Tellurite resistance protein tehB
C5523_RS03945	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
C5523_RS03950	COG2249	NAD(P)H dehydrogenase (quinone) activity
C5523_RS03955	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
C5523_RS03965	COG0204	Acyl-transferase
C5523_RS03990	COG0471	metal ion transport
C5523_RS04000	COG1979	alcohol dehydrogenase
C5523_RS04005	COG2207	Transcriptional regulator
C5523_RS04030	COG0848	biopolymer transport protein
C5523_RS04050	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C5523_RS04060	COG0667	Aldo Keto reductase
C5523_RS04065	COG0840	transmembrane signaling receptor activity
C5523_RS04075	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
C5523_RS04080	COG0437	4 iron, 4 sulfur cluster binding
C5523_RS04085	COG5557	Pfam Polysulphide reductase, NrfD
C5523_RS04090	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
C5523_RS04095	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
C5523_RS04100	COG1773	rubredoxin
C5523_RS04110	COG0298	carbon dioxide binding
C5523_RS04115	COG1349	DNA-binding transcription factor activity
C5523_RS04120	COG5001	Diguanylate cyclase
C5523_RS04125	COG0625	glutathione transferase activity
C5523_RS04165	COG2249	NAD(P)H dehydrogenase (quinone) activity
C5523_RS04245	COG1811	Na channel or pump
C5523_RS04250	COG1982	Orn Lys Arg decarboxylase major
C5523_RS04265	COG3493	citrate carrier protein
C5523_RS04270	COG0179	Fumarylacetoacetate (FAA) hydrolase
C5523_RS04280	COG3052	prosthetic group binding
C5523_RS04300	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
C5523_RS04305	COG2211	Major facilitator Superfamily
C5523_RS04320	COG1194	a g-specific adenine glycosylase
C5523_RS04330	COG3171	Protein conserved in bacteria
C5523_RS04340	COG2852	Protein conserved in bacteria
C5523_RS04355	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
C5523_RS04360	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C5523_RS04365	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C5523_RS04380	COG0762	integral membrane protein
C5523_RS04385	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C5523_RS04390	COG2805	Type II/IV secretion system protein
C5523_RS04405	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C5523_RS04420	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C5523_RS04425	COG2356	endonuclease I
C5523_RS04470	COG2204	response regulator
C5523_RS04475	COG4191	Histidine kinase
C5523_RS04485	COG2814	Major facilitator Superfamily
C5523_RS04505	COG1166	arginine decarboxylase activity
C5523_RS04510	COG0501	Belongs to the peptidase M48B family
C5523_RS04515	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C5523_RS04530	COG0191	fructose-bisphosphate aldolase activity
C5523_RS04535	COG0668	transmembrane transport
C5523_RS04540	COG1279	arginine transmembrane transporter activity
C5523_RS04545	COG2968	Membrane
C5523_RS04550	COG0583	DNA-binding transcription factor activity
C5523_RS04565	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C5523_RS04570	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C5523_RS04595	COG0006	proline dipeptidase activity
C5523_RS04600	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C5523_RS04605	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C5523_RS04630	COG1028	Short-chain dehydrogenase reductase Sdr
C5523_RS04635	COG2723	6-phospho-beta-galactosidase activity
C5523_RS04640	COG1737	Transcriptional regulator
C5523_RS04650	COG1272	protein, Hemolysin III
C5523_RS04685	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C5523_RS04700	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
C5523_RS04705	COG4942	peptidase
C5523_RS04730	COG5564	TIM-barrel signal transduction protein
C5523_RS04735	COG5441	Belongs to the UPF0261 family
C5523_RS04745	COG0840	transmembrane signaling receptor activity
C5523_RS04750	COG2091	lysine biosynthetic process via aminoadipic acid
C5523_RS04755	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C5523_RS04760	COG1028	Short-chain dehydrogenase reductase Sdr
C5523_RS04770	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C5523_RS04815	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C5523_RS04825	COG0204	Acyl-transferase
C5523_RS04825	COG0318	PFAM AMP-dependent synthetase and ligase
C5523_RS04845	COG1971	Probably functions as a manganese efflux pump
C5523_RS04850	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C5523_RS04855	COG4948	Mandelate Racemase Muconate Lactonizing
C5523_RS04865	COG2186	Transcriptional regulator
C5523_RS04870	COG2814	Major facilitator Superfamily
C5523_RS04875	COG1028	Short-chain dehydrogenase reductase Sdr
C5523_RS04890	COG0583	DNA-binding transcription factor activity
C5523_RS04895	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
C5523_RS04900	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C5523_RS04905	COG3300	MHYT domain
C5523_RS04905	COG5001	Diguanylate cyclase
C5523_RS04915	COG0457	Tetratricopeptide repeat
C5523_RS04920	COG1215	transferase activity, transferring glycosyl groups
C5523_RS04925	COG1215	transferase activity, transferring glycosyl groups
C5523_RS04935	COG2199	diguanylate cyclase activity
C5523_RS04935	COG2202	Pas domain
C5523_RS04935	COG2200	EAL domain
C5523_RS04940	COG3706	GGDEF domain
C5523_RS04945	COG0667	Aldo Keto reductase
C5523_RS04950	COG0626	cystathionine gamma-synthase activity
C5523_RS04965	COG2011	ABC-type metal ion transport system permease component
C5523_RS04970	COG1464	Belongs to the NlpA lipoprotein family
C5523_RS04975	COG0183	Belongs to the thiolase family
C5523_RS04985	COG1028	Short-chain dehydrogenase reductase Sdr
C5523_RS05005	COG1794	racemase activity, acting on amino acids and derivatives
C5523_RS05010	COG0583	DNA-binding transcription factor activity
C5523_RS05020	COG1609	Transcriptional regulator
C5523_RS05025	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C5523_RS05030	COG2723	6-phospho-beta-galactosidase activity
C5523_RS05040	COG2186	Transcriptional regulator
C5523_RS05050	COG1609	Transcriptional regulator
C5523_RS05065	COG0477	Major facilitator Superfamily
C5523_RS05070	COG0667	Aldo Keto reductase
C5523_RS05080	COG0861	Integral membrane protein TerC family
C5523_RS05090	COG0494	nUDIX hydrolase
C5523_RS05105	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C5523_RS05110	COG2165	general secretion pathway protein
C5523_RS05115	COG4795	General secretion pathway protein
C5523_RS05125	COG4967	type IV pilus modification protein PilV
C5523_RS05130	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
C5523_RS05140	COG1074	ATP-dependent DNA helicase activity
C5523_RS05145	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C5523_RS05150	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C5523_RS05150	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C5523_RS05155	COG0860	N-Acetylmuramoyl-L-alanine amidase
C5523_RS05180	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
C5523_RS05185	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C5523_RS05190	COG2166	iron-sulfur cluster assembly
C5523_RS05195	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C5523_RS05205	COG0583	DNA-binding transcription factor activity
C5523_RS05210	COG2363	Small membrane protein
C5523_RS05215	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
C5523_RS05225	COG1760	l-serine dehydratase
C5523_RS05230	COG0814	amino acid
C5523_RS05235	COG1611	Belongs to the LOG family
C5523_RS05255	COG3098	single-species biofilm formation
C5523_RS05260	COG0564	pseudouridine synthase activity
C5523_RS05265	COG0716	FMN binding
C5523_RS05270	COG2271	Major facilitator Superfamily
C5523_RS05275	COG4948	Mandelate Racemase Muconate Lactonizing
C5523_RS05280	COG4948	Mandelate Racemase Muconate Lactonizing
C5523_RS05285	COG1929	Belongs to the glycerate kinase type-1 family
C5523_RS05290	COG4999	Histidine kinase
C5523_RS05290	COG3850	Histidine kinase
C5523_RS05290	COG3437	response regulator, receiver
C5523_RS05290	COG2205	protein histidine kinase activity
C5523_RS05300	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C5523_RS05305	COG3956	TIGRFAM MazG family protein
C5523_RS05325	COG0602	queuosine metabolic process
C5523_RS05330	COG0720	synthase
C5523_RS05340	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C5523_RS05360	COG2234	aminopeptidase activity
C5523_RS05380	COG0529	Catalyzes the synthesis of activated sulfate
C5523_RS05390	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
C5523_RS05420	COG4942	peptidase
C5523_RS05420	COG1388	LysM domain
C5523_RS05435	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C5523_RS05440	COG0163	prenyltransferase activity
C5523_RS05450	COG1764	response to oxidative stress
C5523_RS05500	COG3423	Transcriptional regulator
C5523_RS05520	COG2003	Belongs to the UPF0758 family
C5523_RS05525	COG4974	Belongs to the 'phage' integrase family
C5523_RS05580	COG0640	Transcriptional regulator
C5523_RS05585	COG0431	NADPH-dependent FMN reductase
C5523_RS05590	COG3547	Transposase (IS116 IS110 IS902 family)
C5523_RS05595	COG0583	DNA-binding transcription factor activity
C5523_RS05605	COG1560	Kdo2-lipid A biosynthetic process
C5523_RS05615	COG3459	Glycosyltransferase 36 associated
C5523_RS05625	COG1278	Cold shock
C5523_RS05655	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C5523_RS05660	COG0625	glutathione transferase activity
C5523_RS05715	COG2211	Major facilitator Superfamily
C5523_RS05720	COG3507	Belongs to the glycosyl hydrolase 43 family
C5523_RS05740	COG3781	membrane
C5523_RS05745	COG0745	RESPONSE REGULATOR receiver
C5523_RS05775	COG2308	Evidence 4 Homologs of previously reported genes of
C5523_RS05790	COG0309	Hydrogenase expression formation protein (HypE)
C5523_RS05795	COG0409	Hydrogenase expression formation protein
C5523_RS05800	COG0298	carbon dioxide binding
C5523_RS05805	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C5523_RS05820	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
C5523_RS05830	COG2723	6-phospho-beta-galactosidase activity
C5523_RS05835	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C5523_RS05835	COG1263	PTS System
C5523_RS05840	COG1609	Transcriptional regulator
C5523_RS05845	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C5523_RS05850	COG3383	formate dehydrogenase (NAD+) activity
C5523_RS05855	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
C5523_RS05865	COG0426	domain, Protein
C5523_RS05865	COG1773	rubredoxin
C5523_RS05880	COG1349	DNA-binding transcription factor activity
C5523_RS05885	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
C5523_RS05890	COG1028	Short-chain dehydrogenase reductase Sdr
C5523_RS05900	COG3732	PTS system glucitol sorbitol-specific
C5523_RS05905	COG3730	PTS system glucitol sorbitol-specific
C5523_RS05910	COG2951	lytic endotransglycosylase activity
C5523_RS05915	COG1121	(ABC) transporter
C5523_RS05920	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C5523_RS05925	COG0803	Belongs to the bacterial solute-binding protein 9 family
C5523_RS05930	COG1546	Belongs to the CinA family
C5523_RS05950	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C5523_RS05980	COG2823	Periplasmic or secreted lipoprotein
C5523_RS05985	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C5523_RS05990	COG1238	metal cluster binding
C5523_RS06010	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C5523_RS06020	COG0545	Peptidyl-prolyl cis-trans isomerase
C5523_RS06035	COG2814	Major facilitator Superfamily
C5523_RS06040	COG1566	PFAM secretion protein HlyD family protein
C5523_RS06045	COG1846	Transcriptional regulator
C5523_RS06050	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
C5523_RS06055	COG2814	Major facilitator Superfamily
C5523_RS06065	COG4176	ABC-type proline glycine betaine transport system permease component
C5523_RS06075	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C5523_RS06095	COG4575	ribosome binding
C5523_RS06115	COG0401	homolog of Blt101
C5523_RS06130	COG0583	DNA-binding transcription factor activity
C5523_RS06150	COG4232	protein-disulfide reductase activity
C5523_RS06170	COG3179	chitinase
C5523_RS06200	COG0582	viral genome integration into host DNA
C5523_RS06215	COG2867	negative regulation of translational initiation
C5523_RS06235	COG0497	DNA recombination
C5523_RS06250	COG4536	flavin adenine dinucleotide binding
C5523_RS06255	COG4137	Cytochrome C assembly protein
C5523_RS06260	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C5523_RS06415	COG4695	Portal protein
C5523_RS06470	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C5523_RS06505	COG4974	Belongs to the 'phage' integrase family
C5523_RS06520	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C5523_RS06525	COG1605	Chorismate mutase
C5523_RS06525	COG0287	Prephenate dehydrogenase
C5523_RS06535	COG1605	Chorismate mutase
C5523_RS06535	COG0077	Prephenate dehydratase
C5523_RS06545	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C5523_RS06550	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C5523_RS06565	COG0542	response to heat
C5523_RS06600	COG0477	Major facilitator Superfamily
C5523_RS06605	COG5544	Lipoprotein
C5523_RS06610	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C5523_RS06615	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C5523_RS06615	COG0045	succinate-CoA ligase (ADP-forming) activity
C5523_RS06615	COG1042	CoA-binding domain protein
C5523_RS06620	COG3148	PFAM DTW domain containing protein
C5523_RS06625	COG3118	belongs to the thioredoxin family
C5523_RS06630	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C5523_RS06635	COG2033	superoxide reductase activity
C5523_RS06640	COG0318	PFAM AMP-dependent synthetase and ligase
C5523_RS06650	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
C5523_RS06655	COG0644	oxidoreductase
C5523_RS06660	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C5523_RS06665	COG2086	electron transfer activity
C5523_RS06670	COG1960	acyl-CoA dehydrogenase activity
C5523_RS06680	COG2271	Major facilitator Superfamily
C5523_RS06705	COG0513	Belongs to the DEAD box helicase family
C5523_RS06715	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C5523_RS06725	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
C5523_RS06735	COG3086	response to oxidative stress
C5523_RS06745	COG0681	Belongs to the peptidase S26 family
C5523_RS06755	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C5523_RS06765	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C5523_RS06775	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C5523_RS06780	COG1737	Transcriptional regulator
C5523_RS06785	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
C5523_RS06790	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C5523_RS06790	COG1263	PTS System
C5523_RS06795	COG0560	Phosphoserine phosphatase
C5523_RS06830	COG2205	protein histidine kinase activity
C5523_RS06835	COG3170	Tfp pilus assembly protein FimV
C5523_RS06840	COG2204	response regulator
C5523_RS06845	COG0347	Belongs to the P(II) protein family
C5523_RS06850	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C5523_RS06850	COG1017	nitric oxide dioxygenase activity
C5523_RS06870	COG2814	Major facilitator Superfamily
C5523_RS06875	COG3711	transcriptional antiterminator
C5523_RS06880	COG3683	transport system, periplasmic component
C5523_RS06885	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
C5523_RS06910	COG0822	iron-sulfur transferase activity
C5523_RS06930	COG0633	Ferredoxin
C5523_RS06935	COG2975	iron-sulfur cluster assembly
C5523_RS06950	COG1737	Transcriptional regulator
C5523_RS06955	COG2897	thiosulfate sulfurtransferase activity
C5523_RS06965	COG1263	PTS System
C5523_RS06965	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C5523_RS06965	COG2190	(PTS) system
C5523_RS06970	COG2373	Large extracellular alpha-helical protein
C5523_RS06975	COG4953	penicillin-binding protein 1C
C5523_RS07005	COG2976	Protein conserved in bacteria
C5523_RS07020	COG1645	bacterial-type flagellum-dependent swarming motility
C5523_RS07040	COG1570	exodeoxyribonuclease VII activity
C5523_RS07045	COG0516	GMP reductase activity
C5523_RS07045	COG0517	IMP dehydrogenase activity
C5523_RS07050	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C5523_RS07050	COG0519	Catalyzes the synthesis of GMP from XMP
C5523_RS07090	COG2200	EAL domain
C5523_RS07100	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C5523_RS07105	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C5523_RS07120	COG2233	PERMEase
C5523_RS07130	COG1393	Belongs to the ArsC family
C5523_RS07135	COG4783	chaperone-mediated protein folding
C5523_RS07140	COG0628	permease
C5523_RS07145	COG2116	formate transmembrane transporter activity
C5523_RS07150	COG3604	Transcriptional regulator
C5523_RS07160	COG3260	NADH ubiquinone oxidoreductase 20
C5523_RS07165	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C5523_RS07170	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
C5523_RS07170	COG3261	NADH dehydrogenase
C5523_RS07175	COG0651	ATP synthesis coupled electron transport
C5523_RS07180	COG4237	Hydrogenase 4 membrane
C5523_RS07185	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C5523_RS07190	COG0650	Formate hydrogenlyase subunit 4
C5523_RS07195	COG0651	ATP synthesis coupled electron transport
C5523_RS07200	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C5523_RS07205	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C5523_RS07210	COG2716	regulation of RNA biosynthetic process
C5523_RS07220	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
C5523_RS07230	COG2321	neutral zinc metallopeptidase
C5523_RS07240	COG0400	carboxylic ester hydrolase activity
C5523_RS07255	COG1393	Belongs to the ArsC family
C5523_RS07265	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C5523_RS07270	COG3850	Histidine kinase
C5523_RS07280	COG0493	'glutamate synthase
C5523_RS07280	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C5523_RS07285	COG0494	nUDIX hydrolase
C5523_RS07290	COG5342	invasion associated locus B
C5523_RS07295	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C5523_RS07300	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C5523_RS07315	COG0860	N-Acetylmuramoyl-L-alanine amidase
C5523_RS07340	COG2837	iron assimilation
C5523_RS07345	COG4150	thiosulfate binding
C5523_RS07350	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
C5523_RS07355	COG4208	sulfate ABC transporter
C5523_RS07360	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C5523_RS07415	COG3530	Putative quorum-sensing-regulated virulence factor
C5523_RS07420	COG0385	Bile acid
C5523_RS07425	COG0583	DNA-binding transcription factor activity
C5523_RS07460	COG3415	Transposase
C5523_RS07465	COG3415	Transposase
C5523_RS07480	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C5523_RS07495	COG0667	Aldo Keto reductase
C5523_RS07505	COG0837	glucose binding
C5523_RS07510	COG3279	Response regulator of the LytR AlgR family
C5523_RS07515	COG3275	phosphorelay sensor kinase activity
C5523_RS07520	COG0436	Aminotransferase
C5523_RS07530	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
C5523_RS07535	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
C5523_RS07550	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C5523_RS07595	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C5523_RS07635	COG0457	Tetratricopeptide repeat
C5523_RS07640	COG1609	Transcriptional regulator
C5523_RS07650	COG1447	Phosphotransferase system cellobiose-specific component IIA
C5523_RS07655	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C5523_RS07660	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C5523_RS07665	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C5523_RS07680	COG2723	6-phospho-beta-galactosidase activity
C5523_RS07690	COG0840	transmembrane signaling receptor activity
C5523_RS07725	COG1028	Short-chain dehydrogenase reductase Sdr
C5523_RS07735	COG2814	Major facilitator Superfamily
C5523_RS07740	COG0583	DNA-binding transcription factor activity
C5523_RS07750	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C5523_RS07770	COG0583	DNA-binding transcription factor activity
C5523_RS07775	COG0814	amino acid
C5523_RS07780	COG0626	cystathionine gamma-synthase activity
C5523_RS07785	COG0251	oxidation-reduction process
C5523_RS07915	COG0582	viral genome integration into host DNA
C5523_RS07940	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C5523_RS07950	COG2116	formate transmembrane transporter activity
C5523_RS07960	COG2067	long-chain fatty acid transport protein
C5523_RS07970	COG3691	Protein conserved in bacteria
C5523_RS07985	COG2062	phosphohistidine phosphatase, SixA
C5523_RS08010	COG0730	response to heat
C5523_RS08015	COG3101	peptidyl-lysine hydroxylation
C5523_RS08030	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C5523_RS08040	COG2723	6-phospho-beta-galactosidase activity
C5523_RS08055	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C5523_RS08065	COG0586	Pfam SNARE associated Golgi protein
C5523_RS08075	COG0285	dihydrofolate synthase activity
C5523_RS08080	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
C5523_RS08085	COG1286	toxin biosynthetic process
C5523_RS08090	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C5523_RS08095	COG0163	prenyltransferase activity
C5523_RS08115	COG4160	amino acid transport
C5523_RS08120	COG4598	ABC transporter
C5523_RS08130	COG0246	Mannitol dehydrogenase
C5523_RS08135	COG1070	Carbohydrate kinase
C5523_RS08145	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C5523_RS08150	COG1090	epimerase
C5523_RS08155	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C5523_RS08165	COG0625	glutathione transferase activity
C5523_RS08170	COG0622	Phosphoesterase
C5523_RS08210	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C5523_RS08215	COG0471	metal ion transport
C5523_RS08215	COG0490	domain, Protein
C5523_RS08225	COG0436	Aminotransferase
C5523_RS08230	COG0583	DNA-binding transcription factor activity
C5523_RS08265	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C5523_RS08275	COG0839	Belongs to the complex I subunit 6 family
C5523_RS08285	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C5523_RS08290	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C5523_RS08300	COG0784	Response regulator, receiver
C5523_RS08300	COG0835	chemotaxis
C5523_RS08310	COG2153	protein acetylation
C5523_RS08315	COG4575	ribosome binding
C5523_RS08320	COG1169	isochorismate synthase
C5523_RS08340	COG1441	menaquinone biosynthetic process
C5523_RS08350	COG5464	transposase or invertase
C5523_RS08370	COG1414	Transcriptional regulator
C5523_RS08380	COG2271	Major facilitator Superfamily
C5523_RS08390	COG0247	lactate metabolic process
C5523_RS08395	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
C5523_RS08400	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C5523_RS08405	COG2271	Major facilitator Superfamily
C5523_RS08410	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C5523_RS08420	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C5523_RS08450	COG2198	Histidine kinase
C5523_RS08450	COG0642	Histidine kinase
C5523_RS08465	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C5523_RS08465	COG2169	Transcriptional regulator
C5523_RS08470	COG3145	DNA-N1-methyladenine dioxygenase activity
C5523_RS08475	COG4615	Cyclic peptide transporter
C5523_RS08480	COG2239	Acts as a magnesium transporter
C5523_RS08485	COG0659	secondary active sulfate transmembrane transporter activity
C5523_RS08495	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C5523_RS08540	COG1061	Type III restriction enzyme res subunit
C5523_RS08545	COG1187	pseudouridine synthase activity
C5523_RS08550	COG2814	Major facilitator Superfamily
C5523_RS08560	COG4172	Belongs to the ABC transporter superfamily
C5523_RS08565	COG4239	(ABC) transporter, permease
C5523_RS08570	COG4174	ABC transporter (Permease)
C5523_RS08575	COG4166	transmembrane transport
C5523_RS08580	COG2200	EAL domain
C5523_RS08585	COG0791	NLP P60 protein
C5523_RS08595	COG0671	phosphoesterase, PA-phosphatase related
C5523_RS08600	COG0523	cobalamin synthesis protein
C5523_RS08605	COG0246	Mannitol dehydrogenase
C5523_RS08640	COG1105	Belongs to the carbohydrate kinase PfkB family
C5523_RS08645	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C5523_RS08645	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C5523_RS08645	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
C5523_RS08650	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C5523_RS08655	COG2313	pseudouridylate synthase activity
C5523_RS08660	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C5523_RS08665	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C5523_RS08665	COG1522	sequence-specific DNA binding
C5523_RS08675	COG2855	membrane
C5523_RS08680	COG0583	DNA-binding transcription factor activity
C5523_RS08695	COG0765	amino acid transport
C5523_RS08705	COG0833	amino acid
C5523_RS08710	COG4771	TonB-dependent receptor
C5523_RS08720	COG0477	Major facilitator Superfamily
C5523_RS08730	COG2311	Membrane
C5523_RS08745	COG1129	ABC transporter
C5523_RS08755	COG3387	PFAM Glycoside hydrolase 15-related
C5523_RS08765	COG1028	Short-chain dehydrogenase reductase Sdr
C5523_RS08780	COG2949	membrane
C5523_RS08785	COG0295	cytidine deaminase activity
C5523_RS08790	COG1346	cytolysis
C5523_RS08800	COG0583	DNA-binding transcription factor activity
C5523_RS08810	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C5523_RS08825	COG2723	6-phospho-beta-galactosidase activity
C5523_RS08830	COG1028	Short-chain dehydrogenase reductase Sdr
C5523_RS08835	COG0586	Pfam SNARE associated Golgi protein
C5523_RS08845	COG1686	Belongs to the peptidase S11 family
C5523_RS08855	COG0277	FAD linked oxidase domain protein
C5523_RS08860	COG1472	Belongs to the glycosyl hydrolase 3 family
C5523_RS08865	COG1732	Glycine betaine
C5523_RS08870	COG1174	glycine betaine transport
C5523_RS08875	COG1125	glycine betaine transport
C5523_RS08880	COG1174	glycine betaine transport
C5523_RS08890	COG0789	Transcriptional regulator
C5523_RS08895	COG3275	phosphorelay sensor kinase activity
C5523_RS08915	COG4807	Protein conserved in bacteria
C5523_RS08930	COG0489	protein tyrosine kinase activity
C5523_RS08940	COG5455	response to cobalt ion
C5523_RS08945	COG0604	alcohol dehydrogenase
C5523_RS08970	COG0351	phosphomethylpyrimidine kinase
C5523_RS08975	COG1830	Aldolase
C5523_RS08990	COG0826	peptidase U32
C5523_RS09000	COG0745	RESPONSE REGULATOR receiver
C5523_RS09005	COG2205	protein histidine kinase activity
C5523_RS09015	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C5523_RS09025	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C5523_RS09035	COG0443	Heat shock 70 kDa protein
C5523_RS09040	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
C5523_RS09045	COG5002	protein histidine kinase activity
C5523_RS09045	COG3447	MASE1 domain protein
C5523_RS09045	COG5001	Diguanylate cyclase
C5523_RS09060	COG2982	Protein involved in outer membrane biogenesis
C5523_RS09065	COG1253	flavin adenine dinucleotide binding
C5523_RS09090	COG0463	Glycosyl transferase, family 2
C5523_RS09095	COG1045	serine acetyltransferase
C5523_RS09100	COG0438	transferase activity, transferring glycosyl groups
C5523_RS09110	COG1216	Glycosyl transferase, family 2
C5523_RS09115	COG0110	maltose O-acetyltransferase activity
C5523_RS09120	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
C5523_RS09125	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C5523_RS09130	COG1051	belongs to the nudix hydrolase family
C5523_RS09135	COG0297	glycogen (starch) synthase activity
C5523_RS09145	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C5523_RS09150	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C5523_RS09160	COG2244	polysaccharide biosynthetic process
C5523_RS09165	COG2327	Polysaccharide pyruvyl transferase
C5523_RS09255	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C5523_RS09270	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C5523_RS09275	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C5523_RS09285	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C5523_RS09295	COG0531	amino acid
C5523_RS09300	COG2925	Exonuclease
C5523_RS09315	COG1289	transmembrane transporter activity
C5523_RS09330	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C5523_RS09330	COG1648	precorrin-2 dehydrogenase activity
C5523_RS09335	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C5523_RS09355	COG4656	Part of a membrane complex involved in electron transport
C5523_RS09375	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
C5523_RS09385	COG4869	propanediol catabolic process
C5523_RS09550	COG0640	Transcriptional regulator
C5523_RS09555	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C5523_RS09585	COG0583	DNA-binding transcription factor activity
C5523_RS09590	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C5523_RS09615	COG1902	pentaerythritol trinitrate reductase activity
C5523_RS09620	COG0583	DNA-binding transcription factor activity
C5523_RS09640	COG0534	Mate efflux family protein
C5523_RS09650	COG1175	transmembrane transport
C5523_RS09660	COG3833	ABC-type maltose transport systems, permease component
C5523_RS09670	COG1028	Short-chain dehydrogenase reductase Sdr
C5523_RS09675	COG1349	DNA-binding transcription factor activity
C5523_RS09680	COG0434	BtpA family
C5523_RS09685	COG1070	Carbohydrate kinase
C5523_RS09695	COG1349	DNA-binding transcription factor activity
C5523_RS09700	COG2202	Pas domain
C5523_RS09700	COG2200	EAL domain
C5523_RS09700	COG2199	diguanylate cyclase activity
C5523_RS09710	COG0006	proline dipeptidase activity
C5523_RS09715	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C5523_RS09720	COG0604	alcohol dehydrogenase
C5523_RS09725	COG1309	transcriptional regulator
C5523_RS09760	COG0583	DNA-binding transcription factor activity
C5523_RS09770	COG0583	DNA-binding transcription factor activity
C5523_RS09780	COG3228	Belongs to the MtfA family
C5523_RS09790	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C5523_RS09795	COG1418	mRNA catabolic process
C5523_RS09800	COG3727	T/G mismatch-specific endonuclease activity
C5523_RS09805	COG0697	spore germination
C5523_RS09810	COG2354	Protein conserved in bacteria
C5523_RS09815	COG5475	Uncharacterized small protein (DUF2158)
C5523_RS09840	COG2197	response regulator
C5523_RS09885	COG2882	bacterial-type flagellum organization
C5523_RS09895	COG1317	bacterial-type flagellum organization
C5523_RS09910	COG1677	Flagellar hook-basal body complex protein FliE
C5523_RS09915	COG0425	Belongs to the sulfur carrier protein TusA family
C5523_RS09920	COG2391	methyltransferase activity
C5523_RS09930	COG0366	Alpha amylase catalytic
C5523_RS09945	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
C5523_RS09950	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C5523_RS09980	COG0318	PFAM AMP-dependent synthetase and ligase
C5523_RS09985	COG3958	Transketolase
C5523_RS09990	COG3959	Transketolase, thiamine diphosphate binding domain
C5523_RS09995	COG1028	Short-chain dehydrogenase reductase Sdr
C5523_RS10000	COG1028	Short-chain dehydrogenase reductase Sdr
C5523_RS10025	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5523_RS10035	COG0765	amino acid transport
C5523_RS10040	COG1126	abc transporter atp-binding protein
C5523_RS10045	COG2197	response regulator
C5523_RS10055	COG2197	response regulator
C5523_RS10115	COG3381	protein complex oligomerization
C5523_RS10165	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
C5523_RS10170	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C5523_RS10195	COG5645	(Lipo)protein
C5523_RS10210	COG1560	Kdo2-lipid A biosynthetic process
C5523_RS10225	COG3038	cytochrome b561
C5523_RS10260	COG2999	glutathione oxidoreductase activity
C5523_RS10270	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C5523_RS10275	COG3132	Protein of unknown function, DUF480
C5523_RS10280	COG0673	inositol 2-dehydrogenase activity
C5523_RS10320	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
C5523_RS10325	COG1749	Flagellar hook protein flgE
C5523_RS10330	COG4787	bacterial-type flagellum-dependent cell motility
C5523_RS10355	COG1256	bacterial-type flagellum assembly
C5523_RS10365	COG2814	Major facilitator Superfamily
C5523_RS10370	COG0583	DNA-binding transcription factor activity
C5523_RS10375	COG1530	ribonuclease E activity
C5523_RS10430	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C5523_RS10435	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C5523_RS10440	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C5523_RS10450	COG0470	DNA polymerase III
C5523_RS10455	COG0084	hydrolase, TatD family'
C5523_RS10465	COG4773	Receptor
C5523_RS10470	COG0537	adenosine 5'-monophosphoramidase activity
C5523_RS10475	COG5633	Lipoprotein
C5523_RS10480	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
C5523_RS10500	COG1252	NADH dehydrogenase
C5523_RS10505	COG3134	Outer membrane lipoprotein
C5523_RS10510	COG1309	transcriptional regulator
C5523_RS10520	COG1376	ErfK ybiS ycfS ynhG family protein
C5523_RS10520	COG1388	LysM domain
C5523_RS10525	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C5523_RS10530	COG4763	Acyl-transferase
C5523_RS10535	COG4591	ABC-type transport system involved in lipoprotein release permease component
C5523_RS10540	COG1136	(ABC) transporter
C5523_RS10545	COG4591	ABC-type transport system involved in lipoprotein release permease component
C5523_RS10560	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
C5523_RS10575	COG1177	transmembrane transport
C5523_RS10595	COG2850	peptidyl-arginine hydroxylation
C5523_RS10600	COG2205	protein histidine kinase activity
C5523_RS10605	COG0745	RESPONSE REGULATOR receiver
C5523_RS10610	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C5523_RS10625	COG0840	transmembrane signaling receptor activity
C5523_RS10645	COG0538	isocitrate dehydrogenase activity
C5523_RS10675	COG2203	Gaf domain
C5523_RS10675	COG2199	diguanylate cyclase activity
C5523_RS10680	COG3042	response to heat
C5523_RS10690	COG3189	MarR family transcriptional regulator
C5523_RS10700	COG0504	CTP synthase activity
C5523_RS10705	COG2807	transmembrane transport
C5523_RS10710	COG2207	Transcriptional regulator
C5523_RS10715	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5523_RS10725	COG0765	amino acid transport
C5523_RS10730	COG0765	amino acid transport
C5523_RS10745	COG2211	Major facilitator Superfamily
C5523_RS10755	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C5523_RS10760	COG2718	Belongs to the UPF0229 family
C5523_RS10765	COG2766	serine protein kinase
C5523_RS10770	COG3713	MltA-interacting MipA family protein
C5523_RS10775	COG0656	L-ascorbic acid biosynthetic process
C5523_RS10795	COG3139	Protein of unknown function (DUF1315)
C5523_RS10800	COG1335	isochorismatase
C5523_RS10805	COG0252	asparaginase activity
C5523_RS10810	COG0616	signal peptide processing
C5523_RS10815	COG0778	Nitroreductase
C5523_RS10820	COG0709	Synthesizes selenophosphate from selenide and ATP
C5523_RS10825	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C5523_RS10840	COG0494	nUDIX hydrolase
C5523_RS10845	COG2897	thiosulfate sulfurtransferase activity
C5523_RS10860	COG1228	amidohydrolase
C5523_RS10870	COG0402	S-adenosylhomocysteine deaminase activity
C5523_RS10880	COG2358	TRAP transporter, solute receptor (TAXI family
C5523_RS10885	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C5523_RS10895	COG2986	histidine ammonia-lyase
C5523_RS10900	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C5523_RS10905	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C5523_RS10935	COG1012	belongs to the aldehyde dehydrogenase family
C5523_RS10940	COG3724	N-succinylarginine dihydrolase activity
C5523_RS10955	COG3678	ATP-independent chaperone mediated protein folding
C5523_RS10965	COG0322	excinuclease ABC activity
C5523_RS10975	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C5523_RS10980	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C5523_RS10985	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C5523_RS10990	COG1447	Phosphotransferase system cellobiose-specific component IIA
C5523_RS10995	COG1917	Cupin 2, conserved barrel domain protein
C5523_RS10995	COG2169	Transcriptional regulator
C5523_RS11000	COG1486	melibiose metabolic process
C5523_RS11010	COG0753	catalase activity
C5523_RS11020	COG1823	symporter activity
C5523_RS11025	COG1988	membrane-bound metal-dependent
C5523_RS11030	COG1028	Short-chain dehydrogenase reductase Sdr
C5523_RS11035	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C5523_RS11045	COG3001	Fructosamine kinase
C5523_RS11055	COG1105	Belongs to the carbohydrate kinase PfkB family
C5523_RS11060	COG3137	Salt-induced outer membrane protein
C5523_RS11105	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C5523_RS11105	COG0072	phenylalanine-tRNA ligase activity
C5523_RS11110	COG0776	regulation of translation
C5523_RS11120	COG0386	Belongs to the glutathione peroxidase family
C5523_RS11130	COG0791	NLP P60 protein
C5523_RS11145	COG4256	Hemin uptake protein
C5523_RS11160	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C5523_RS11160	COG0574	Belongs to the PEP-utilizing enzyme family
C5523_RS11185	COG0628	permease
C5523_RS11190	COG0247	lactate metabolic process
C5523_RS11190	COG0277	FAD linked oxidase domain protein
C5523_RS11195	COG2050	protein possibly involved in aromatic compounds catabolism
C5523_RS11200	COG1560	Kdo2-lipid A biosynthetic process
C5523_RS11210	COG3443	Belongs to the bacterial solute-binding protein 9 family
C5523_RS11225	COG0316	Belongs to the HesB IscA family
C5523_RS11230	COG0719	Fe-S assembly protein
C5523_RS11235	COG0396	ATPase activity
C5523_RS11240	COG0719	Fe-S assembly protein
C5523_RS11245	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C5523_RS11250	COG2166	iron-sulfur cluster assembly
C5523_RS11255	COG1376	ErfK ybiS ycfS ynhG family protein
C5523_RS11275	COG0483	inositol monophosphate 1-phosphatase activity
C5523_RS11280	COG1064	alcohol dehydrogenase
C5523_RS11310	COG4106	trans-aconitate 2-methyltransferase activity
C5523_RS11315	COG0307	riboflavin synthase, alpha
C5523_RS11320	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C5523_RS11325	COG2814	Major facilitator Superfamily
C5523_RS11330	COG0583	DNA-binding transcription factor activity
C5523_RS11350	COG2814	Major facilitator Superfamily
C5523_RS11360	COG0791	NLP P60 protein
C5523_RS11365	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C5523_RS11375	COG0346	lactoylglutathione lyase activity
C5523_RS11380	COG1902	pentaerythritol trinitrate reductase activity
C5523_RS11385	COG1309	transcriptional regulator
C5523_RS11390	COG3313	Fe-S protein
C5523_RS11395	COG4989	oxidoreductase activity
C5523_RS11400	COG2032	superoxide dismutase activity
C5523_RS11410	COG1566	PFAM secretion protein HlyD family protein
C5523_RS11430	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
C5523_RS11435	COG3895	Periplasmic Protein
C5523_RS11450	COG0625	glutathione transferase activity
C5523_RS11465	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C5523_RS11475	COG4659	FMN binding
C5523_RS11515	COG0673	inositol 2-dehydrogenase activity
C5523_RS11530	COG5339	Protein conserved in bacteria
C5523_RS11535	COG1482	cell wall glycoprotein biosynthetic process
C5523_RS11540	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
C5523_RS11540	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
C5523_RS11545	COG0114	fumarate hydratase activity
C5523_RS11555	COG2205	protein histidine kinase activity
C5523_RS11560	COG0745	RESPONSE REGULATOR receiver
C5523_RS11565	COG3136	membrane protein required for alginate biosynthesis
C5523_RS11570	COG1028	Short-chain dehydrogenase reductase Sdr
C5523_RS11575	COG0531	amino acid
C5523_RS11590	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
C5523_RS11595	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
C5523_RS11600	COG0668	transmembrane transport
C5523_RS11620	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C5523_RS11625	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C5523_RS11630	COG2840	Smr protein MutS2
C5523_RS11635	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C5523_RS11645	COG0583	DNA-binding transcription factor activity
C5523_RS11650	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C5523_RS11665	COG0840	transmembrane signaling receptor activity
C5523_RS11675	COG1028	Short-chain dehydrogenase reductase Sdr
C5523_RS11695	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C5523_RS11700	COG2233	PERMEase
C5523_RS11705	COG3648	Uricase
C5523_RS11705	COG3195	allantoin biosynthetic process
C5523_RS11710	COG2351	hydroxyisourate hydrolase activity
C5523_RS11715	COG0402	S-adenosylhomocysteine deaminase activity
C5523_RS11725	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C5523_RS11730	COG1733	regulation of RNA biosynthetic process
C5523_RS11755	COG1309	transcriptional regulator
C5523_RS11760	COG0243	molybdopterin cofactor binding
C5523_RS11760	COG3383	formate dehydrogenase (NAD+) activity
C5523_RS11765	COG0437	4 iron, 4 sulfur cluster binding
C5523_RS11770	COG2864	formate dehydrogenase
C5523_RS11780	COG5002	protein histidine kinase activity
C5523_RS11785	COG0745	RESPONSE REGULATOR receiver
C5523_RS11795	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C5523_RS11810	COG0583	DNA-binding transcription factor activity
C5523_RS11825	COG3122	Protein conserved in bacteria
C5523_RS11840	COG0840	transmembrane signaling receptor activity
C5523_RS11845	COG5001	Diguanylate cyclase
C5523_RS11845	COG1716	ATPase activity
C5523_RS11850	COG0384	phenazine biosynthesis protein PhzF
C5523_RS11900	COG1538	Outer membrane efflux protein
C5523_RS11905	COG1289	transmembrane transporter activity
C5523_RS11970	COG1085	galactose-1-phosphate uridylyltransferase
C5523_RS11980	COG2182	Extracellular solute-binding protein
C5523_RS11985	COG1175	transmembrane transport
C5523_RS11990	COG3833	ABC-type maltose transport systems, permease component
C5523_RS11995	COG3867	Arabinogalactan endo-beta-1,4-galactanase
C5523_RS12000	COG1874	Beta-galactosidase
C5523_RS12005	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C5523_RS12005	COG1263	PTS System
C5523_RS12020	COG4221	oxidoreductase activity
C5523_RS12030	COG2814	Major facilitator Superfamily
C5523_RS12045	COG2207	Transcriptional regulator
C5523_RS12055	COG2205	protein histidine kinase activity
C5523_RS12060	COG0745	RESPONSE REGULATOR receiver
C5523_RS12070	COG0402	S-adenosylhomocysteine deaminase activity
C5523_RS12080	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C5523_RS12085	COG0583	DNA-binding transcription factor activity
C5523_RS12105	COG2207	Transcriptional regulator
C5523_RS12110	COG1028	Short-chain dehydrogenase reductase Sdr
C5523_RS12135	COG0386	Belongs to the glutathione peroxidase family
C5523_RS12155	COG2963	transposase activity
C5523_RS12205	COG3157	Type VI secretion system effector, Hcp
C5523_RS12285	COG0463	Glycosyl transferase, family 2
C5523_RS12295	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C5523_RS12300	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C5523_RS12305	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C5523_RS12310	COG1120	ATPase activity
C5523_RS12320	COG4943	cyclic-guanylate-specific phosphodiesterase activity
C5523_RS12345	COG1175	transmembrane transport
C5523_RS12355	COG3842	ATPase activity
C5523_RS12370	COG0628	permease
C5523_RS12375	COG2076	Multidrug Resistance protein
C5523_RS12390	COG3591	Belongs to the peptidase S1B family
C5523_RS12400	COG0456	acetyltransferase
C5523_RS12405	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
C5523_RS12410	COG2814	Major facilitator Superfamily
C5523_RS12415	COG0583	DNA-binding transcription factor activity
C5523_RS12420	COG1940	carbohydrate kinase activity
C5523_RS12425	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C5523_RS12455	COG3302	dmso reductase anchor subunit
C5523_RS12460	COG0437	4 iron, 4 sulfur cluster binding
C5523_RS12465	COG0243	molybdopterin cofactor binding
C5523_RS12475	COG0583	DNA-binding transcription factor activity
C5523_RS12490	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C5523_RS12505	COG1063	alcohol dehydrogenase
C5523_RS12510	COG0477	Major facilitator Superfamily
C5523_RS12515	COG4948	Mandelate Racemase Muconate Lactonizing
C5523_RS12525	COG0246	Mannitol dehydrogenase
C5523_RS12535	COG1802	Transcriptional regulator
C5523_RS12540	COG4221	oxidoreductase activity
C5523_RS12545	COG0339	signal peptide processing
C5523_RS12600	COG1566	PFAM secretion protein HlyD family protein
C5523_RS12615	COG2207	Transcriptional regulator
C5523_RS12640	COG1278	Cold shock
C5523_RS12645	COG2223	nitrite transmembrane transporter activity
C5523_RS12675	COG2814	Major facilitator Superfamily
C5523_RS12680	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
C5523_RS12685	COG4221	oxidoreductase activity
C5523_RS12695	COG1028	Short-chain dehydrogenase reductase Sdr
C5523_RS12725	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C5523_RS12735	COG2814	Major facilitator Superfamily
C5523_RS12740	COG0697	spore germination
C5523_RS12755	COG1846	Transcriptional regulator
C5523_RS12765	COG2814	Major facilitator Superfamily
C5523_RS12795	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C5523_RS12800	COG1454	alcohol dehydrogenase
C5523_RS12805	COG3395	kinase activity
C5523_RS12810	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C5523_RS12815	COG1349	DNA-binding transcription factor activity
C5523_RS12820	COG0039	L-malate dehydrogenase activity
C5523_RS12830	COG0583	DNA-binding transcription factor activity
C5523_RS12835	COG1012	belongs to the aldehyde dehydrogenase family
C5523_RS12840	COG0840	transmembrane signaling receptor activity
C5523_RS12855	COG2199	diguanylate cyclase activity
C5523_RS12865	COG3706	GGDEF domain
C5523_RS12875	COG0246	Mannitol dehydrogenase
C5523_RS12885	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C5523_RS12890	COG0583	DNA-binding transcription factor activity
C5523_RS12895	COG1012	belongs to the aldehyde dehydrogenase family
C5523_RS12920	COG0840	transmembrane signaling receptor activity
C5523_RS12925	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
C5523_RS12940	COG3604	Transcriptional regulator
C5523_RS12945	COG2205	protein histidine kinase activity
C5523_RS13135	COG0697	spore germination
C5523_RS13140	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C5523_RS13150	COG1275	C4-dicarboxylate transporter malic acid transport protein
C5523_RS13165	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C5523_RS13170	COG2188	Transcriptional regulator
C5523_RS13185	COG0494	nUDIX hydrolase
C5523_RS13195	COG3038	cytochrome b561
C5523_RS13200	COG0640	Transcriptional regulator
C5523_RS13215	COG1028	Short-chain dehydrogenase reductase Sdr
C5523_RS13220	COG2610	gluconate transmembrane transporter activity
C5523_RS13225	COG1250	3-hydroxyacyl-CoA dehydrogenase
C5523_RS13240	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C5523_RS13265	COG1649	PFAM Uncharacterised BCR, COG1649
C5523_RS13270	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C5523_RS13275	COG0527	aspartate kinase activity
C5523_RS13280	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C5523_RS13285	COG0076	glutamate decarboxylase activity
C5523_RS13295	COG2271	Major facilitator Superfamily
C5523_RS13305	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C5523_RS13310	COG1028	Short-chain dehydrogenase reductase Sdr
C5523_RS13350	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C5523_RS13355	COG1120	ATPase activity
C5523_RS13375	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C5523_RS13385	COG4977	sequence-specific DNA binding
C5523_RS13390	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C5523_RS13410	COG1126	abc transporter atp-binding protein
C5523_RS13415	COG0765	amino acid transport
C5523_RS13420	COG0765	amino acid transport
C5523_RS13425	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5523_RS13430	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
C5523_RS13430	COG0456	acetyltransferase
C5523_RS13450	COG2207	Transcriptional regulator
C5523_RS13475	COG2814	Major facilitator Superfamily
C5523_RS13500	COG5001	Diguanylate cyclase
C5523_RS13500	COG3706	GGDEF domain
C5523_RS13500	COG4251	negative regulation of phosphorylation
C5523_RS13500	COG2203	Gaf domain
C5523_RS13505	COG2200	EAL domain
C5523_RS13510	COG0840	transmembrane signaling receptor activity
C5523_RS13530	COG0174	glutamine synthetase
C5523_RS13535	COG0488	(ABC) transporter
C5523_RS13545	COG2814	Major facilitator Superfamily
C5523_RS13565	COG2864	formate dehydrogenase
C5523_RS13570	COG0437	4 iron, 4 sulfur cluster binding
C5523_RS13580	COG0697	spore germination
C5523_RS13590	COG5654	RES domain protein
C5523_RS13605	COG2162	N-hydroxyarylamine O-acetyltransferase activity
C5523_RS13610	COG1178	ABC-type Fe3 transport system permease component
C5523_RS13615	COG1840	ABC-type Fe3 transport system, periplasmic component
C5523_RS13620	COG3842	ATPase activity
C5523_RS13630	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
C5523_RS13635	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C5523_RS13650	COG2211	Major facilitator Superfamily
C5523_RS13660	COG1942	4-Oxalocrotonate Tautomerase
C5523_RS13665	COG0625	glutathione transferase activity
C5523_RS13670	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C5523_RS13670	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C5523_RS13675	COG1609	Transcriptional regulator
C5523_RS13685	COG2271	Major facilitator Superfamily
C5523_RS13690	COG1126	abc transporter atp-binding protein
C5523_RS13705	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C5523_RS13710	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C5523_RS13715	COG1473	amidohydrolase
C5523_RS13720	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C5523_RS13735	COG4772	TonB-dependent receptor
C5523_RS13745	COG1802	Transcriptional regulator
C5523_RS13750	COG2130	NADP-dependent
C5523_RS13760	COG1247	-acetyltransferase
C5523_RS13765	COG3238	Protein conserved in bacteria
C5523_RS13775	COG0747	negative chemotaxis
C5523_RS13835	COG1177	transmembrane transport
C5523_RS13840	COG1176	ABC-type spermidine putrescine transport system, permease component I
C5523_RS13845	COG3842	ATPase activity
C5523_RS13850	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C5523_RS13855	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C5523_RS13860	COG1271	oxidase subunit
C5523_RS13865	COG1294	oxidase, subunit
C5523_RS13875	COG0840	transmembrane signaling receptor activity
C5523_RS13885	COG0826	peptidase U32
C5523_RS13890	COG1396	sequence-specific DNA binding
C5523_RS13895	COG3135	benzoate transporter
C5523_RS13900	COG1917	Cupin 2, conserved barrel domain protein
C5523_RS13900	COG2207	Transcriptional regulator
C5523_RS13915	COG0747	negative chemotaxis
C5523_RS13920	COG2195	Cleaves the N-terminal amino acid of tripeptides
C5523_RS13925	COG0500	methyltransferase
C5523_RS13930	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C5523_RS13935	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C5523_RS13940	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
C5523_RS13950	COG0436	Aminotransferase
C5523_RS13960	COG2272	Belongs to the type-B carboxylesterase lipase family
C5523_RS13965	COG5383	Protein conserved in bacteria
C5523_RS13970	COG0583	DNA-binding transcription factor activity
C5523_RS13990	COG0840	transmembrane signaling receptor activity
C5523_RS14010	COG1285	pathogenesis
C5523_RS14020	COG3813	Protein conserved in bacteria
C5523_RS14025	COG0477	Major facilitator Superfamily
C5523_RS14030	COG3038	cytochrome b561
C5523_RS14035	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C5523_RS14040	COG0657	acetylesterase activity
C5523_RS14040	COG2755	lipolytic protein G-D-S-L family
C5523_RS14045	COG1012	belongs to the aldehyde dehydrogenase family
C5523_RS14050	COG1434	Gram-negative-bacterium-type cell wall biogenesis
C5523_RS14075	COG4122	O-methyltransferase activity
C5523_RS14080	COG1643	Atp-dependent helicase
C5523_RS14095	COG2911	Protein conserved in bacteria
C5523_RS14100	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C5523_RS14105	COG3187	Heat shock protein
C5523_RS14110	COG3042	response to heat
C5523_RS14120	COG0071	Belongs to the small heat shock protein (HSP20) family
C5523_RS14125	COG1013	pyruvate-flavodoxin oxidoreductase activity
C5523_RS14125	COG0674	pyruvate-flavodoxin oxidoreductase activity
C5523_RS14125	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C5523_RS14125	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C5523_RS14145	COG0840	transmembrane signaling receptor activity
C5523_RS14155	COG3706	GGDEF domain
C5523_RS14165	COG4166	transmembrane transport
C5523_RS14170	COG2866	Carboxypeptidase
C5523_RS14175	COG4948	Mandelate Racemase Muconate Lactonizing
C5523_RS14180	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
C5523_RS14205	COG3106	COG3106 Predicted ATPase
C5523_RS14210	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C5523_RS14220	COG1983	PspC domain protein
C5523_RS14230	COG1842	Phage shock protein A
C5523_RS14235	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C5523_RS14250	COG4171	peptide transport system, permease
C5523_RS14255	COG4172	Belongs to the ABC transporter superfamily
C5523_RS14275	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C5523_RS14275	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C5523_RS14285	COG5001	Diguanylate cyclase
C5523_RS14290	COG1024	Enoyl-CoA hydratase
C5523_RS14300	COG1349	DNA-binding transcription factor activity
C5523_RS14310	COG0023	Translation Initiation Factor
C5523_RS14320	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
C5523_RS14325	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
C5523_RS14330	COG0671	phosphoesterase, PA-phosphatase related
C5523_RS14365	COG0616	signal peptide processing
C5523_RS14370	COG1028	Short-chain dehydrogenase reductase Sdr
C5523_RS14375	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
C5523_RS14380	COG1187	pseudouridine synthase activity
C5523_RS14385	COG0009	L-threonylcarbamoyladenylate synthase
C5523_RS14400	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C5523_RS14400	COG0512	Glutamine amidotransferase of anthranilate synthase
C5523_RS14405	COG0135	phosphoribosylanthranilate isomerase activity
C5523_RS14405	COG0134	indole-3-glycerol-phosphate synthase activity
C5523_RS14425	COG3047	cAMP biosynthetic process
C5523_RS14430	COG0727	PFAM Uncharacterised protein family (UPF0153)
C5523_RS14455	COG2350	Protein conserved in bacteria
C5523_RS14510	COG0444	Belongs to the ABC transporter superfamily
C5523_RS14530	COG2095	MarC family integral membrane protein
C5523_RS14535	COG1012	belongs to the aldehyde dehydrogenase family
C5523_RS14535	COG1454	alcohol dehydrogenase
C5523_RS14540	COG1435	thymidine kinase activity
C5523_RS14550	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C5523_RS14555	COG0745	RESPONSE REGULATOR receiver
C5523_RS14560	COG1752	Esterase of the alpha-beta hydrolase superfamily
C5523_RS14570	COG0788	formyltetrahydrofolate deformylase activity
C5523_RS14610	COG1522	sequence-specific DNA binding
C5523_RS14615	COG0697	spore germination
C5523_RS14620	COG2181	nitrate reductase activity
C5523_RS14625	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
C5523_RS14630	COG1140	nitrate reductase beta subunit
C5523_RS14635	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
C5523_RS14640	COG2223	nitrite transmembrane transporter activity
C5523_RS14645	COG3850	Histidine kinase
C5523_RS14650	COG2197	response regulator
C5523_RS14655	COG4932	domain protein
C5523_RS14665	COG0243	molybdopterin cofactor binding
C5523_RS14670	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C5523_RS14670	COG2146	nitrite reductase [NAD(P)H] activity
C5523_RS14675	COG1116	anion transmembrane transporter activity
C5523_RS14685	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C5523_RS14690	COG3707	response regulator
C5523_RS14695	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
C5523_RS14700	COG0840	transmembrane signaling receptor activity
C5523_RS14710	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
C5523_RS14715	COG4572	Cation transport regulator
C5523_RS14720	COG0387	Pfam Sodium calcium exchanger
C5523_RS14725	COG0596	Alpha beta hydrolase
C5523_RS14755	COG2890	protein-(glutamine-N5) methyltransferase activity
C5523_RS14760	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C5523_RS14790	COG0659	secondary active sulfate transmembrane transporter activity
C5523_RS14810	COG0012	GTP binding
C5523_RS14885	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C5523_RS14890	COG0247	lactate metabolic process
C5523_RS14895	COG1139	Iron-sulfur cluster binding protein
C5523_RS14900	COG1556	Lactate utilization protein
C5523_RS14910	COG4251	negative regulation of phosphorylation
C5523_RS14910	COG3706	GGDEF domain
C5523_RS14910	COG5001	Diguanylate cyclase
C5523_RS14910	COG2203	Gaf domain
C5523_RS14915	COG2271	Major facilitator Superfamily
C5523_RS14935	COG3842	ATPase activity
C5523_RS14940	COG3321	synthase
C5523_RS14940	COG1028	Short-chain dehydrogenase reductase Sdr
C5523_RS14940	COG0604	alcohol dehydrogenase
C5523_RS14950	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C5523_RS14955	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C5523_RS14960	COG0583	DNA-binding transcription factor activity
C5523_RS14975	COG1176	ABC-type spermidine putrescine transport system, permease component I
C5523_RS14980	COG1177	transmembrane transport
C5523_RS14990	COG5001	Diguanylate cyclase
C5523_RS14990	COG3300	MHYT domain
C5523_RS14995	COG1454	alcohol dehydrogenase
C5523_RS15005	COG1215	transferase activity, transferring glycosyl groups
C5523_RS15010	COG1649	PFAM Uncharacterised BCR, COG1649
C5523_RS15010	COG0726	polysaccharide deacetylase
C5523_RS15015	COG0457	Tetratricopeptide repeat
C5523_RS15030	COG0583	DNA-binding transcription factor activity
C5523_RS15055	COG3842	ATPase activity
C5523_RS15065	COG1609	Transcriptional regulator
C5523_RS15070	COG0483	inositol monophosphate 1-phosphatase activity
C5523_RS15085	COG1201	RNA secondary structure unwinding
C5523_RS15105	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
C5523_RS15115	COG3729	General stress protein
C5523_RS15120	COG3729	General stress protein
C5523_RS15125	COG3685	Protein conserved in bacteria
C5523_RS15130	COG3685	Protein conserved in bacteria
C5523_RS15135	COG3546	catalase activity
C5523_RS15140	COG1271	oxidase subunit
C5523_RS15145	COG1294	oxidase, subunit
C5523_RS15155	COG1546	Belongs to the CinA family
C5523_RS15160	COG1063	alcohol dehydrogenase
C5523_RS15165	COG1294	oxidase, subunit
C5523_RS15170	COG1271	oxidase subunit
C5523_RS15180	COG3383	formate dehydrogenase (NAD+) activity
C5523_RS15220	COG0583	DNA-binding transcription factor activity
C5523_RS15235	COG0583	DNA-binding transcription factor activity
C5523_RS15240	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C5523_RS15250	COG1028	Short-chain dehydrogenase reductase Sdr
C5523_RS15255	COG2814	Major facilitator Superfamily
C5523_RS15265	COG0604	alcohol dehydrogenase
C5523_RS15320	COG0745	RESPONSE REGULATOR receiver
C5523_RS15335	COG1733	regulation of RNA biosynthetic process
C5523_RS15365	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C5523_RS15370	COG0583	DNA-binding transcription factor activity
C5523_RS15375	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C5523_RS15405	COG3290	protein histidine kinase activity
C5523_RS15410	COG4565	transcriptional regulatory protein
C5523_RS15455	COG2376	Dihydroxyacetone kinase
C5523_RS15460	COG1461	Dihydroxyacetone kinase
C5523_RS15500	COG0583	DNA-binding transcription factor activity
C5523_RS15505	COG0583	DNA-binding transcription factor activity
C5523_RS15515	COG0435	Glutathione S-transferase
C5523_RS15555	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C5523_RS15625	COG1309	transcriptional regulator
C5523_RS15630	COG0251	oxidation-reduction process
C5523_RS15650	COG0583	DNA-binding transcription factor activity
C5523_RS15655	COG0667	Aldo Keto reductase
C5523_RS15660	COG2814	Major facilitator Superfamily
C5523_RS15665	COG2207	Transcriptional regulator
C5523_RS15680	COG2814	Major facilitator Superfamily
C5523_RS15685	COG1566	PFAM secretion protein HlyD family protein
C5523_RS15690	COG1846	Transcriptional regulator
C5523_RS15715	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
C5523_RS15725	COG3639	organic phosphonate transmembrane transporter activity
C5523_RS15740	COG3507	Belongs to the glycosyl hydrolase 43 family
C5523_RS15745	COG3507	Belongs to the glycosyl hydrolase 43 family
C5523_RS15750	COG2211	Major facilitator Superfamily
C5523_RS15760	COG2211	Major facilitator Superfamily
C5523_RS15765	COG2207	Transcriptional regulator
C5523_RS15765	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C5523_RS15775	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C5523_RS15780	COG4558	Periplasmic binding protein
C5523_RS15785	COG3720	iron ion transport
C5523_RS15800	COG2964	Protein conserved in bacteria
C5523_RS15815	COG2203	Gaf domain
C5523_RS15815	COG4251	negative regulation of phosphorylation
C5523_RS15815	COG5001	Diguanylate cyclase
C5523_RS15815	COG3706	GGDEF domain
C5523_RS15820	COG1776	CheC inhibitor of MCP methylation
C5523_RS15825	COG2197	response regulator
C5523_RS15835	COG3284	Transcriptional regulator
C5523_RS16075	COG1397	ADP-ribosylglycohydrolase
C5523_RS16080	COG4104	PAAR repeat-containing protein
C5523_RS16095	COG1397	ADP-ribosylglycohydrolase
C5523_RS16165	COG0515	serine threonine protein kinase
C5523_RS16305	COG1619	proteins homologs of microcin C7 resistance protein MccF
C5523_RS16310	COG3263	regulation of cellular component size
C5523_RS16315	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C5523_RS16325	COG2719	SpoVR family
C5523_RS16350	COG0179	Fumarylacetoacetate (FAA) hydrolase
C5523_RS16360	COG0850	regulation of cytokinetic process
C5523_RS16365	COG2894	cell division
C5523_RS16375	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
C5523_RS16385	COG3065	identical protein binding
C5523_RS16395	COG1199	ATP-dependent helicase activity
C5523_RS16400	COG0251	oxidation-reduction process
C5523_RS16425	COG1760	l-serine dehydratase
C5523_RS16430	COG2200	EAL domain
C5523_RS16435	COG1253	flavin adenine dinucleotide binding
C5523_RS16445	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C5523_RS16445	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C5523_RS16450	COG3715	PTS system
C5523_RS16455	COG3716	PTS system mannose fructose sorbose family IID component
C5523_RS16475	COG2226	methyltransferase
C5523_RS16515	COG1414	Transcriptional regulator
C5523_RS16520	COG2814	Major facilitator Superfamily
C5523_RS16540	COG1956	GAF domain-containing protein
C5523_RS16545	COG2995	paraquat-inducible protein a
C5523_RS16550	COG3008	intermembrane lipid transfer
C5523_RS16570	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C5523_RS16575	COG2990	Protein conserved in bacteria
C5523_RS16590	COG2135	peptidase activity
C5523_RS16595	COG2755	lipolytic protein G-D-S-L family
C5523_RS16595	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C5523_RS16640	COG1196	nuclear chromosome segregation
C5523_RS16710	COG4220	transposase activity
C5523_RS16760	COG1403	HNH endonuclease
C5523_RS16805	COG0863	Belongs to the N(4) N(6)-methyltransferase family
C5523_RS16890	COG1276	copper resistance
C5523_RS16895	COG2372	response to copper ion
C5523_RS16905	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C5523_RS16910	COG1770	oligopeptidase
C5523_RS16915	COG2979	Protein of unknown function (DUF533)
C5523_RS16925	COG3141	response to X-ray
C5523_RS16940	COG3121	Chaperone
C5523_RS16945	COG0800	Aldolase
C5523_RS16950	COG0129	dihydroxy-acid dehydratase activity
C5523_RS16955	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C5523_RS16960	COG1737	Transcriptional regulator
C5523_RS16965	COG0469	pyruvate kinase activity
C5523_RS16970	COG1560	Kdo2-lipid A biosynthetic process
C5523_RS16975	COG0739	heme binding
C5523_RS16980	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
C5523_RS16990	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C5523_RS17025	COG0494	nUDIX hydrolase
C5523_RS17035	COG1335	isochorismatase
C5523_RS17040	COG1801	Protein of unknown function DUF72
C5523_RS17045	COG3788	relative of glutathione S-transferase, MAPEG superfamily
C5523_RS17065	COG3142	Participates in the control of copper homeostasis
C5523_RS17070	COG3102	Protein conserved in bacteria
C5523_RS17075	COG3272	Protein of unknown function (DUF1722)
C5523_RS17095	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C5523_RS17110	COG0300	oxidoreductase activity
C5523_RS17120	COG0789	Transcriptional regulator
C5523_RS17130	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
C5523_RS17135	COG2211	Major facilitator Superfamily
C5523_RS17150	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C5523_RS17165	COG0745	RESPONSE REGULATOR receiver
C5523_RS17180	COG0840	transmembrane signaling receptor activity
C5523_RS17270	COG1172	Belongs to the binding-protein-dependent transport system permease family
C5523_RS17280	COG1879	ABC-type sugar transport system periplasmic component
C5523_RS17300	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
C5523_RS17320	COG1528	Iron-storage protein
C5523_RS17330	COG0814	amino acid
C5523_RS17335	COG3318	Belongs to the UPF0149 family
C5523_RS17335	COG3012	SEC-C Motif Domain Protein
C5523_RS17345	COG1702	phosphate starvation-inducible protein PhoH
C5523_RS17355	COG2822	iron ion transport
C5523_RS17365	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C5523_RS17375	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C5523_RS17385	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C5523_RS17385	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C5523_RS17385	COG0506	proline dehydrogenase activity
C5523_RS17395	COG1309	transcriptional regulator
C5523_RS17415	COG2267	carboxylic ester hydrolase activity
C5523_RS17425	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C5523_RS17435	COG3729	General stress protein
C5523_RS17475	COG4221	oxidoreductase activity
C5523_RS17500	COG3772	lysozyme
C5523_RS17530	COG1301	dicarboxylic acid transport
C5523_RS17605	COG1396	sequence-specific DNA binding
C5523_RS17670	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5523_RS17675	COG0765	amino acid transport
C5523_RS17680	COG0765	amino acid transport
C5523_RS17685	COG1126	abc transporter atp-binding protein
C5523_RS17705	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C5523_RS17715	COG0747	negative chemotaxis
C5523_RS17720	COG2072	flavoprotein involved in K transport
C5523_RS17725	COG4251	negative regulation of phosphorylation
C5523_RS17725	COG3706	GGDEF domain
C5523_RS17725	COG2203	Gaf domain
C5523_RS17725	COG5001	Diguanylate cyclase
C5523_RS17745	COG0670	Belongs to the BI1 family
C5523_RS17755	COG1254	Belongs to the acylphosphatase family
C5523_RS17765	COG1881	PFAM PEBP family protein
C5523_RS17770	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C5523_RS17780	COG1832	CoA-binding protein
C5523_RS17785	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
C5523_RS17795	COG0210	DNA helicase
C5523_RS17800	COG3304	Inner membrane component domain
C5523_RS17805	COG1289	transmembrane transporter activity
C5523_RS17810	COG3070	regulator of competence-specific genes
C5523_RS17835	COG1067	ATP-dependent peptidase activity
C5523_RS17845	COG3130	regulation of translation
C5523_RS17850	COG3009	Protein conserved in bacteria
C5523_RS17855	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C5523_RS17855	COG3008	intermembrane lipid transfer
C5523_RS17860	COG2995	paraquat-inducible protein a
C5523_RS17865	COG0488	(ABC) transporter
C5523_RS17875	COG3217	Mosc domain protein beta barrel domain protein
C5523_RS17875	COG0633	Ferredoxin
C5523_RS17890	COG0431	NADPH-dependent FMN reductase
C5523_RS17895	COG0308	aminopeptidase N
C5523_RS18020	COG4626	Terminase
C5523_RS18020	COG1802	Transcriptional regulator
C5523_RS18050	COG3772	lysozyme
C5523_RS18080	COG0484	heat shock protein binding
C5523_RS18085	COG1403	HNH endonuclease
C5523_RS18095	COG4725	Belongs to the MT-A70-like family
C5523_RS18140	COG5532	Uncharacterized conserved protein (DUF2303)
C5523_RS18160	COG0582	viral genome integration into host DNA
C5523_RS18165	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C5523_RS18185	COG1448	Aminotransferase
C5523_RS18190	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C5523_RS18195	COG3108	Peptidase M15
C5523_RS18205	COG2989	Protein conserved in bacteria
C5523_RS18215	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
C5523_RS18225	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C5523_RS18230	COG1434	Gram-negative-bacterium-type cell wall biogenesis
C5523_RS18235	COG3173	Aminoglycoside phosphotransferase
C5523_RS18245	COG2835	tetraacyldisaccharide 4'-kinase activity
C5523_RS18250	COG3214	Protein conserved in bacteria
C5523_RS18265	COG2333	competence protein COMEC
C5523_RS18265	COG0658	competence protein
C5523_RS18275	COG0539	negative regulation of cytoplasmic translation
C5523_RS18280	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C5523_RS18285	COG0501	Belongs to the peptidase M48B family
C5523_RS18305	COG2323	membrane
C5523_RS18310	COG1944	ATP diphosphatase activity
C5523_RS18315	COG2116	formate transmembrane transporter activity
C5523_RS18320	COG1882	Formate acetyltransferase
C5523_RS18325	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C5523_RS18335	COG0477	Major facilitator Superfamily
C5523_RS18340	COG3302	dmso reductase anchor subunit
C5523_RS18345	COG0437	4 iron, 4 sulfur cluster binding
C5523_RS18350	COG0243	molybdopterin cofactor binding
C5523_RS18360	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C5523_RS18385	COG0492	ferredoxin-NADP+ reductase activity
C5523_RS18390	COG4988	ABC transporter
C5523_RS18395	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C5523_RS18410	COG0542	response to heat
C5523_RS18420	COG1278	Cold shock
C5523_RS18430	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C5523_RS18435	COG2990	Protein conserved in bacteria
C5523_RS18440	COG3593	DNA synthesis involved in DNA repair
C5523_RS18450	COG1151	hydroxylamine reductase activity
C5523_RS18455	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C5523_RS18465	COG0028	Belongs to the TPP enzyme family
C5523_RS18470	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
C5523_RS18475	COG0702	epimerase
C5523_RS18480	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C5523_RS18485	COG3023	N-Acetylmuramoyl-L-alanine amidase
C5523_RS18490	COG0393	Putative heavy-metal-binding
C5523_RS18500	COG1126	abc transporter atp-binding protein
C5523_RS18505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5523_RS18510	COG4215	(ABC) transporter
C5523_RS18515	COG4160	amino acid transport
C5523_RS18520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5523_RS18525	COG5002	protein histidine kinase activity
C5523_RS18530	COG0745	RESPONSE REGULATOR receiver
C5523_RS18555	COG1177	transmembrane transport
C5523_RS18560	COG1176	ABC-type spermidine putrescine transport system, permease component I
C5523_RS18565	COG3842	ATPase activity
C5523_RS18570	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C5523_RS18585	COG0778	Nitroreductase
C5523_RS18610	COG3226	Transcriptional regulator
C5523_RS18615	COG0738	Major facilitator superfamily
C5523_RS18625	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C5523_RS18635	COG3850	Histidine kinase
C5523_RS18635	COG5002	protein histidine kinase activity
C5523_RS18640	COG0745	RESPONSE REGULATOR receiver
C5523_RS18645	COG3713	MltA-interacting MipA family protein
C5523_RS18660	COG2814	Major facilitator Superfamily
C5523_RS18665	COG0671	phosphoesterase, PA-phosphatase related
C5523_RS18670	COG1349	DNA-binding transcription factor activity
C5523_RS18675	COG1686	Belongs to the peptidase S11 family
C5523_RS18680	COG0625	glutathione transferase activity
C5523_RS18685	COG2133	pyrroloquinoline quinone binding
C5523_RS18700	COG0439	Biotin carboxylase
C5523_RS18705	COG3665	Urea carboxylase-associated protein
C5523_RS18715	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C5523_RS18745	COG2271	Major facilitator Superfamily
C5523_RS18750	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C5523_RS18755	COG0583	DNA-binding transcription factor activity
C5523_RS18770	COG0747	negative chemotaxis
C5523_RS18775	COG4172	Belongs to the ABC transporter superfamily
C5523_RS18780	COG1446	asparaginase
C5523_RS18785	COG0303	'Molybdopterin
C5523_RS18790	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C5523_RS18795	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C5523_RS18800	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C5523_RS18805	COG1882	Formate acetyltransferase
C5523_RS18810	COG0561	phosphatase activity
C5523_RS18820	COG1609	Transcriptional regulator
C5523_RS18825	COG2271	Major facilitator Superfamily
C5523_RS18840	COG0488	(ABC) transporter
C5523_RS18845	COG1376	ErfK ybiS ycfS ynhG family protein
C5523_RS18850	COG2188	Transcriptional regulator
C5523_RS18855	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C5523_RS18860	COG2723	6-phospho-beta-galactosidase activity
C5523_RS18865	COG0667	Aldo Keto reductase
C5523_RS18875	COG2814	Major facilitator Superfamily
C5523_RS18880	COG1566	PFAM secretion protein HlyD family protein
C5523_RS18885	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
C5523_RS18890	COG1321	iron dependent repressor
C5523_RS18905	COG2194	sulfuric ester hydrolase activity
C5523_RS18910	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
C5523_RS18925	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5523_RS18930	COG0765	amino acid transport
C5523_RS18935	COG1126	abc transporter atp-binding protein
C5523_RS18940	COG0668	transmembrane transport
C5523_RS18950	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C5523_RS18955	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C5523_RS18970	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C5523_RS18975	COG1199	ATP-dependent helicase activity
C5523_RS18985	COG3711	transcriptional antiterminator
C5523_RS18990	COG1263	PTS System
C5523_RS18990	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C5523_RS18990	COG2190	(PTS) system
C5523_RS18995	COG2723	6-phospho-beta-galactosidase activity
C5523_RS19000	COG2723	6-phospho-beta-galactosidase activity
C5523_RS19005	COG0657	acetylesterase activity
C5523_RS19015	COG0513	Belongs to the DEAD box helicase family
C5523_RS19020	COG1309	transcriptional regulator
C5523_RS19025	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C5523_RS19030	COG1131	(ABC) transporter
C5523_RS19035	COG0842	Transport permease protein
C5523_RS19040	COG0842	Transport permease protein
C5523_RS19050	COG3568	Endonuclease Exonuclease Phosphatase
C5523_RS19055	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C5523_RS19060	COG0392	lysyltransferase activity
C5523_RS19070	COG0670	Belongs to the BI1 family
C5523_RS19075	COG0314	molybdopterin synthase activity
C5523_RS19080	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
C5523_RS19090	COG0521	Mo-molybdopterin cofactor biosynthetic process
C5523_RS19100	COG0391	Required for morphogenesis under gluconeogenic growth conditions
C5523_RS19105	COG2194	sulfuric ester hydrolase activity
C5523_RS19155	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C5523_RS19165	COG1881	PFAM PEBP family protein
C5523_RS19170	COG4677	pectinesterase activity
C5523_RS19180	COG0561	phosphatase activity
C5523_RS19185	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
C5523_RS19190	COG4149	molybdate abc transporter
C5523_RS19195	COG0725	ABC transporter, periplasmic molybdate-binding protein
C5523_RS19210	COG2005	Transcriptional regulator
C5523_RS19210	COG3585	molybdate ion transport
C5523_RS19215	COG1119	ATPase activity
C5523_RS19220	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C5523_RS19225	COG1085	galactose-1-phosphate uridylyltransferase
C5523_RS19235	COG2017	converts alpha-aldose to the beta-anomer
C5523_RS19250	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C5523_RS19270	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C5523_RS19305	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
C5523_RS19310	COG2885	chlorophyll binding
C5523_RS19320	COG3064	Membrane
C5523_RS19325	COG0848	biopolymer transport protein
C5523_RS19330	COG0811	peptide transport
C5523_RS19335	COG0824	Thioesterase
C5523_RS19340	COG3790	cyd operon protein YbgE
C5523_RS19345	COG4890	Cyd operon protein YbgT
C5523_RS19350	COG1294	oxidase, subunit
C5523_RS19355	COG1271	oxidase subunit
C5523_RS19360	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C5523_RS19365	COG2814	Major facilitator Superfamily
C5523_RS19375	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C5523_RS19385	COG0508	dehydrogenase complex catalyzes the overall conversion of
C5523_RS19390	COG0567	Dehydrogenase, E1 component
C5523_RS19405	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
C5523_RS19410	COG2009	succinate dehydrogenase
C5523_RS19435	COG1984	allophanate hydrolase subunit 2
C5523_RS19440	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C5523_RS19445	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C5523_RS19450	COG0415	Belongs to the DNA photolyase family
C5523_RS19465	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
C5523_RS19470	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
C5523_RS19480	COG2205	protein histidine kinase activity
C5523_RS19485	COG0745	RESPONSE REGULATOR receiver
C5523_RS19490	COG0033	Phosphoglucomutase
C5523_RS19495	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
C5523_RS19500	COG0596	Alpha beta hydrolase
C5523_RS19520	COG0735	belongs to the Fur family
C5523_RS19540	COG2190	(PTS) system
C5523_RS19540	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C5523_RS19540	COG1263	PTS System
C5523_RS19550	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C5523_RS19555	COG1846	Transcriptional regulator
C5523_RS19555	COG1940	carbohydrate kinase activity
C5523_RS19565	COG0647	UMP catabolic process
C5523_RS19570	COG0367	asparagine synthase
C5523_RS19615	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C5523_RS19625	COG1702	phosphate starvation-inducible protein PhoH
C5523_RS19630	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C5523_RS19635	COG4535	Mg2 and Co2 transporter CorC
C5523_RS19650	COG0765	amino acid transport
C5523_RS19655	COG0765	amino acid transport
C5523_RS19660	COG1126	abc transporter atp-binding protein
C5523_RS19670	COG2888	peptidyl-tyrosine sulfation
C5523_RS19685	COG1466	dna polymerase III delta subunit
C5523_RS19705	COG0799	negative regulation of ribosome biogenesis
C5523_RS19715	COG0768	penicillin binding
C5523_RS19720	COG0772	Belongs to the SEDS family
C5523_RS19725	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C5523_RS19735	COG1686	Belongs to the peptidase S11 family
C5523_RS19740	COG2921	Belongs to the UPF0250 family
C5523_RS19750	COG0583	DNA-binding transcription factor activity
C5523_RS19760	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C5523_RS19765	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C5523_RS19780	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C5523_RS19785	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C5523_RS19805	COG3069	C4-dicarboxylate transmembrane transporter activity
C5523_RS19810	COG3719	Belongs to the RNase T2 family
C5523_RS19815	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C5523_RS19840	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C5523_RS19845	COG3969	phosphoadenosine phosphosulfate
C5523_RS19850	COG1475	DNA binding
C5523_RS19855	COG0436	Aminotransferase
C5523_RS19860	COG0235	Class ii aldolase
C5523_RS19865	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
C5523_RS19925	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
C5523_RS19945	COG1172	Belongs to the binding-protein-dependent transport system permease family
C5523_RS19950	COG1129	ABC transporter
C5523_RS19955	COG0371	Dehydrogenase
C5523_RS19960	COG1309	transcriptional regulator
C5523_RS19970	COG2879	small protein
C5523_RS19975	COG1966	Carbon starvation protein
C5523_RS19985	COG1028	Short-chain dehydrogenase reductase Sdr
C5523_RS19990	COG1535	isochorismatase
C5523_RS19990	COG3433	isochorismatase activity
C5523_RS19995	COG1021	2,3-dihydroxybenzoate-AMP ligase
C5523_RS20000	COG1169	isochorismate synthase
C5523_RS20005	COG4592	Periplasmic binding protein
C5523_RS20010	COG0477	Major facilitator Superfamily
C5523_RS20015	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C5523_RS20020	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C5523_RS20025	COG1120	ATPase activity
C5523_RS20030	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
C5523_RS20030	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C5523_RS20035	COG3251	PFAM MbtH domain protein
C5523_RS20040	COG2382	esterase
C5523_RS20050	COG4771	TonB-dependent receptor
C5523_RS20055	COG2977	Belongs to the P-Pant transferase superfamily
C5523_RS20060	COG1879	ABC-type sugar transport system periplasmic component
C5523_RS20070	COG1129	ABC transporter
C5523_RS20075	COG1172	Belongs to the binding-protein-dependent transport system permease family
C5523_RS20080	COG2390	Transcriptional regulator
C5523_RS20085	COG3959	Transketolase, thiamine diphosphate binding domain
C5523_RS20090	COG3958	Transketolase
C5523_RS20100	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C5523_RS20115	COG0601	transmembrane transport
C5523_RS20120	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C5523_RS20125	COG0444	Belongs to the ABC transporter superfamily
C5523_RS20130	COG4608	Belongs to the ABC transporter superfamily
C5523_RS20140	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C5523_RS20145	COG4221	oxidoreductase activity
C5523_RS20155	COG4215	(ABC) transporter
C5523_RS20160	COG0765	amino acid transport
C5523_RS20170	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C5523_RS20200	COG2315	Protein conserved in bacteria
C5523_RS20205	COG0384	phenazine biosynthesis protein PhzF
C5523_RS20215	COG0477	Major facilitator Superfamily
C5523_RS20225	COG1609	Transcriptional regulator
C5523_RS20240	COG2211	Major facilitator Superfamily
C5523_RS20245	COG1113	amino acid transport
C5523_RS20275	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
C5523_RS20300	COG0511	ligase activity, forming carbon-carbon bonds
C5523_RS20305	COG4297	protein containing double-stranded beta helix domain
C5523_RS20320	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
C5523_RS20325	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C5523_RS20330	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C5523_RS20335	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C5523_RS20345	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C5523_RS20345	COG0493	'glutamate synthase
C5523_RS20365	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
C5523_RS20420	COG1401	restriction endodeoxyribonuclease activity
C5523_RS20430	COG0477	Major facilitator Superfamily
C5523_RS20440	COG5002	protein histidine kinase activity
C5523_RS20455	COG0840	transmembrane signaling receptor activity
C5523_RS20465	COG3182	Iron-regulated membrane protein
C5523_RS20475	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C5523_RS20480	COG3300	MHYT domain
C5523_RS20480	COG5001	Diguanylate cyclase
C5523_RS20485	COG0840	transmembrane signaling receptor activity
C5523_RS20490	COG3416	Protein conserved in bacteria
C5523_RS20570	COG1312	Catalyzes the dehydration of D-mannonate
C5523_RS20610	COG0840	transmembrane signaling receptor activity
C5523_RS20615	COG2200	EAL domain
C5523_RS20635	COG0583	DNA-binding transcription factor activity
C5523_RS20665	COG0583	DNA-binding transcription factor activity
C5523_RS20680	COG0583	DNA-binding transcription factor activity
C5523_RS20685	COG2814	Major facilitator Superfamily
C5523_RS20700	COG0583	DNA-binding transcription factor activity
C5523_RS20705	COG2828	Protein conserved in bacteria
C5523_RS20710	COG2814	Major facilitator Superfamily
C5523_RS20715	COG0179	Fumarylacetoacetate (FAA) hydrolase
C5523_RS20720	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
C5523_RS20725	COG3052	prosthetic group binding
C5523_RS20745	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
C5523_RS20755	COG1049	propionate catabolic process, 2-methylcitrate cycle
C5523_RS20760	COG0471	metal ion transport
C5523_RS20765	COG0471	metal ion transport
C5523_RS20775	COG1696	Membrane protein involved in D-alanine export
C5523_RS20780	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C5523_RS20790	COG0840	transmembrane signaling receptor activity
C5523_RS20800	COG5002	protein histidine kinase activity
C5523_RS20890	COG0582	viral genome integration into host DNA
C5523_RS20905	COG2501	S4 domain
C5523_RS20910	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C5523_RS20910	COG2190	(PTS) system
C5523_RS20910	COG1263	PTS System
C5523_RS20915	COG1609	Transcriptional regulator
C5523_RS20920	COG1988	membrane-bound metal-dependent
C5523_RS20930	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C5523_RS20945	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C5523_RS20950	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C5523_RS20965	COG1464	Belongs to the NlpA lipoprotein family
C5523_RS20975	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
C5523_RS20980	COG4181	ATPase activity
C5523_RS20985	COG2755	lipolytic protein G-D-S-L family
C5523_RS20990	COG0300	oxidoreductase activity
C5523_RS20995	COG3118	belongs to the thioredoxin family
C5523_RS21000	COG0330	HflC and HflK could
C5523_RS21005	COG1585	Membrane protein implicated in regulation of membrane protease activity
C5523_RS21030	COG3735	TraB family
C5523_RS21040	COG0737	Belongs to the 5'-nucleotidase family
C5523_RS21045	COG2223	nitrite transmembrane transporter activity
C5523_RS21050	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C5523_RS21050	COG4651	solute:proton antiporter activity
C5523_RS21055	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C5523_RS21065	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C5523_RS21110	COG2832	Protein of unknown function (DUF454)
C5523_RS21115	COG3923	Primosomal replication protein n
C5523_RS21125	COG1196	nuclear chromosome segregation
C5523_RS21125	COG3264	Mechanosensitive ion channel
C5523_RS21130	COG1309	transcriptional regulator
C5523_RS21135	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C5523_RS21140	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C5523_RS21155	COG0110	maltose O-acetyltransferase activity
C5523_RS21175	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C5523_RS21190	COG1464	Belongs to the NlpA lipoprotein family
C5523_RS21200	COG2011	ABC-type metal ion transport system permease component
C5523_RS21205	COG1263	PTS System
C5523_RS21205	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C5523_RS21205	COG2190	(PTS) system
C5523_RS21210	COG4948	Mandelate Racemase Muconate Lactonizing
C5523_RS21215	COG2188	Transcriptional regulator
C5523_RS21220	COG4943	cyclic-guanylate-specific phosphodiesterase activity
C5523_RS21225	COG5507	3-demethylubiquinone-9 3-methyltransferase
C5523_RS21230	COG3250	beta-galactosidase activity
C5523_RS21235	COG1609	Transcriptional regulator
C5523_RS21260	COG3695	enzyme binding
C5523_RS21265	COG3126	Type III secretion system lipoprotein chaperone (YscW)
C5523_RS21270	COG1946	Acyl-CoA thioesterase
C5523_RS21275	COG0004	ammonium transporteR
C5523_RS21280	COG0347	Belongs to the P(II) protein family
C5523_RS21285	COG1132	(ABC) transporter
C5523_RS21290	COG1132	(ABC) transporter
C5523_RS21295	COG1522	sequence-specific DNA binding
C5523_RS21305	COG0561	phosphatase activity
C5523_RS21310	COG4533	DNA binding
C5523_RS21320	COG0824	Thioesterase
C5523_RS21325	COG1555	photosystem II stabilization
C5523_RS21330	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C5523_RS21335	COG0776	regulation of translation
C5523_RS21340	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C5523_RS21365	COG0271	Belongs to the BolA IbaG family
C5523_RS21370	COG3056	Lipoprotein
C5523_RS21375	COG2223	nitrite transmembrane transporter activity
C5523_RS21385	COG0443	Heat shock 70 kDa protein
C5523_RS21390	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C5523_RS21395	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C5523_RS21400	COG1845	cytochrome c oxidase, subunit III
C5523_RS21405	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
C5523_RS21415	COG2814	Major facilitator Superfamily
C5523_RS21425	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C5523_RS21450	COG0142	geranyltranstransferase activity
C5523_RS21460	COG0667	Aldo Keto reductase
C5523_RS21465	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C5523_RS21475	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C5523_RS21485	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C5523_RS21485	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C5523_RS21495	COG4238	major outer membrane lipoprotein
C5523_RS21500	COG3248	Nucleoside-binding outer membrane protein
C5523_RS21515	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C5523_RS21520	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C5523_RS21525	COG1862	Preprotein translocase
C5523_RS21535	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C5523_RS21540	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
C5523_RS21555	COG0366	Alpha amylase catalytic
C5523_RS21580	COG5002	protein histidine kinase activity
C5523_RS21590	COG0420	3'-5' exonuclease activity
C5523_RS21595	COG0419	ATPase involved in DNA repair
C5523_RS21600	COG1940	carbohydrate kinase activity
C5523_RS21615	COG4126	flavin adenine dinucleotide binding
C5523_RS21625	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C5523_RS21635	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C5523_RS21645	COG3706	GGDEF domain
C5523_RS21655	COG1785	Belongs to the alkaline phosphatase family
C5523_RS21695	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
C5523_RS21705	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C5523_RS21720	COG0113	porphobilinogen synthase activity
C5523_RS21740	COG2271	Major facilitator Superfamily
C5523_RS21745	COG1840	ABC-type Fe3 transport system, periplasmic component
C5523_RS21755	COG3842	ATPase activity
C5523_RS21760	COG0531	amino acid
C5523_RS21765	COG4303	Ethanolamine ammonia lyase large subunit
C5523_RS21770	COG4302	ethanolamine ammonia-lyase activity
C5523_RS21780	COG2323	membrane
C5523_RS21790	COG0148	phosphopyruvate hydratase activity
C5523_RS21800	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C5523_RS21805	COG3971	2-oxopent-4-enoate hydratase activity
C5523_RS21815	COG1609	Transcriptional regulator
C5523_RS21830	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C5523_RS21835	COG4948	Mandelate Racemase Muconate Lactonizing
C5523_RS21845	COG0683	leucine binding
C5523_RS21895	COG5001	Diguanylate cyclase
C5523_RS21935	COG2807	transmembrane transport
C5523_RS21940	COG1846	Transcriptional regulator
C5523_RS21980	COG0582	viral genome integration into host DNA
C5523_RS21990	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C5523_RS21995	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C5523_RS22000	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C5523_RS22015	COG0765	amino acid transport
C5523_RS22020	COG0765	amino acid transport
C5523_RS22025	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5523_RS22060	COG2195	Cleaves the N-terminal amino acid of tripeptides
C5523_RS22070	COG3034	peptidoglycan biosynthetic process
C5523_RS22075	COG0121	glutamine amidotransferase
C5523_RS22090	COG1960	acyl-CoA dehydrogenase activity
C5523_RS22095	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C5523_RS22105	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C5523_RS22150	COG1953	Uracil, thiamine, allantoin
C5523_RS22290	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C5523_RS22300	COG2226	methyltransferase
C5523_RS22310	COG1388	LysM domain
C5523_RS22310	COG0741	lytic transglycosylase activity
C5523_RS22315	COG2226	methyltransferase
C5523_RS22320	COG3021	interspecies interaction between organisms
C5523_RS22325	COG0583	DNA-binding transcription factor activity
C5523_RS22345	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C5523_RS22385	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C5523_RS22395	COG2011	ABC-type metal ion transport system permease component
C5523_RS22400	COG1464	Belongs to the NlpA lipoprotein family
C5523_RS22410	COG1720	tRNA m6t6A37 methyltransferase activity
C5523_RS22420	COG3015	lipoprotein NlpE involved in copper resistance
C5523_RS22425	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
C5523_RS22430	COG4681	YaeQ
C5523_RS22440	COG4568	rho-dependent transcription termination
C5523_RS22445	COG0037	tRNA processing
C5523_RS22450	COG0346	lactoylglutathione lyase activity
C5523_RS22455	COG1982	Orn Lys Arg decarboxylase major
C5523_RS22490	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C5523_RS22500	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C5523_RS22510	COG0575	Belongs to the CDS family
C5523_RS22520	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C5523_RS22535	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C5523_RS22565	COG3835	regulator
C5523_RS22595	COG2860	membrane
C5523_RS22605	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C5523_RS22610	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C5523_RS22615	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C5523_RS22620	COG1120	ATPase activity
C5523_RS22625	COG4774	siderophore transport
C5523_RS22630	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C5523_RS22635	COG1643	Atp-dependent helicase
C5523_RS22640	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
C5523_RS22645	COG1489	DNA binding
C5523_RS22655	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C5523_RS22665	COG0617	tRNA 3'-terminal CCA addition
C5523_RS22670	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C5523_RS22675	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C5523_RS22680	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C5523_RS22695	COG0726	polysaccharide deacetylase
C5523_RS22700	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C5523_RS22705	COG0842	Transport permease protein
C5523_RS22710	COG1131	(ABC) transporter
C5523_RS22715	COG0288	reversible hydration of carbon dioxide
C5523_RS22725	COG4993	Dehydrogenase
C5523_RS22730	COG2132	Multicopper oxidase
C5523_RS22755	COG1049	propionate catabolic process, 2-methylcitrate cycle
C5523_RS22770	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C5523_RS22775	COG0508	dehydrogenase complex catalyzes the overall conversion of
C5523_RS22780	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C5523_RS22790	COG2186	Transcriptional regulator
C5523_RS22795	COG1113	amino acid transport
C5523_RS22800	COG2211	Major facilitator Superfamily
C5523_RS22805	COG3940	Belongs to the glycosyl hydrolase 43 family
C5523_RS22810	COG3725	Membrane protein required for beta-lactamase induction
C5523_RS22825	COG4969	Belongs to the N-Me-Phe pilin family
C5523_RS22830	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C5523_RS22835	COG1459	type II secretion system
C5523_RS22860	COG0494	nUDIX hydrolase
C5523_RS22880	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C5523_RS22885	COG0849	cell division
C5523_RS22910	COG0772	Belongs to the SEDS family
C5523_RS22925	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C5523_RS22930	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C5523_RS22935	COG0768	penicillin binding
C5523_RS22950	COG2001	Belongs to the MraZ family
C5523_RS22970	COG0028	Belongs to the TPP enzyme family
C5523_RS22985	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C5523_RS23010	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C5523_RS23015	COG0738	Major facilitator superfamily
C5523_RS23025	COG0583	DNA-binding transcription factor activity
C5523_RS23030	COG2271	Major facilitator Superfamily
C5523_RS23035	COG2814	Major facilitator Superfamily
C5523_RS23055	COG1178	ABC-type Fe3 transport system permease component
C5523_RS23060	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
C5523_RS23065	COG0586	Pfam SNARE associated Golgi protein
C5523_RS23075	COG1069	ribulokinase activity
C5523_RS23080	COG2160	L-arabinose isomerase activity
C5523_RS23085	COG0235	Class ii aldolase
C5523_RS23095	COG0417	DNA replication proofreading
C5523_RS23100	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C5523_RS23105	COG0564	pseudouridine synthase activity
C5523_RS23115	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C5523_RS23120	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
C5523_RS23125	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C5523_RS23130	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C5523_RS23145	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C5523_RS23180	COG2271	Major facilitator Superfamily
C5523_RS23185	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
C5523_RS23190	COG0644	oxidoreductase
C5523_RS23245	COG0505	Belongs to the CarA family
C5523_RS23275	COG1047	Peptidyl-prolyl cis-trans
C5523_RS23280	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C5523_RS23290	COG0196	riboflavin kinase activity
C5523_RS23310	COG0640	Transcriptional regulator
C5523_RS23325	COG0583	DNA-binding transcription factor activity
C5523_RS23340	COG0641	radical SAM
C5523_RS23345	COG3119	arylsulfatase activity
C5523_RS23365	COG1584	GPR1 FUN34 yaaH family protein
C5523_RS23375	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C5523_RS23380	COG1120	ATPase activity
C5523_RS23390	COG0477	Major facilitator Superfamily
C5523_RS23395	COG0521	Mo-molybdopterin cofactor biosynthetic process
C5523_RS23405	COG1115	amino acid carrier protein
C5523_RS23420	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C5523_RS23430	COG0527	aspartate kinase activity
C5523_RS23430	COG0460	homoserine dehydrogenase
C5523_RS23440	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
C5523_RS23455	COG0745	RESPONSE REGULATOR receiver
C5523_RS23460	COG4452	Inner membrane protein CreD
C5523_RS23465	COG2205	protein histidine kinase activity
C5523_RS23470	COG0745	RESPONSE REGULATOR receiver
C5523_RS23475	COG3045	CreA protein
C5523_RS23480	COG2207	Transcriptional regulator
C5523_RS23480	COG3708	Transcriptional regulator
C5523_RS23500	COG0741	lytic transglycosylase activity
C5523_RS23505	COG0488	(ABC) transporter
C5523_RS23520	COG0560	Phosphoserine phosphatase
C5523_RS23525	COG3726	membrane protein affecting hemolysin expression
C5523_RS23540	COG0813	purine-nucleoside phosphorylase activity
C5523_RS23560	COG1328	CTP reductase activity
C5523_RS23565	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C5523_RS23570	COG0084	hydrolase, TatD family'
C5523_RS23575	COG4667	esterase of the alpha-beta hydrolase superfamily
C5523_RS23585	COG2823	Periplasmic or secreted lipoprotein
C5523_RS23595	COG1011	Hydrolase
C5523_RS23600	COG0456	acetyltransferase
C5523_RS23605	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
C5523_RS23640	COG4114	ferric iron reductase
C5523_RS23645	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C5523_RS23650	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C5523_RS23655	COG2197	response regulator
C5523_RS23660	COG2197	response regulator
C5523_RS23670	COG2966	Psort location CytoplasmicMembrane, score
C5523_RS23680	COG1309	transcriptional regulator
C5523_RS23685	COG1846	Transcriptional regulator
C5523_RS23690	COG1764	response to oxidative stress
C5523_RS23700	COG1484	DNA-dependent DNA replication
C5523_RS23715	COG1063	alcohol dehydrogenase
C5523_RS23720	COG1802	Transcriptional regulator
C5523_RS23725	COG2271	Major facilitator Superfamily
C5523_RS23735	COG0840	transmembrane signaling receptor activity
C5523_RS23745	COG1966	Carbon starvation protein
C5523_RS23750	COG2879	small protein
C5523_RS23755	COG0523	cobalamin synthesis protein
C5523_RS23775	COG1322	Protein conserved in bacteria
C5523_RS23780	COG2733	membrane
C5523_RS23785	COG0859	PFAM glycosyl transferase family 9
C5523_RS23790	COG2814	Major facilitator Superfamily
C5523_RS23795	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
C5523_RS23800	COG1924	4 iron, 4 sulfur cluster binding
C5523_RS23820	COG1566	PFAM secretion protein HlyD family protein
C5523_RS23860	COG1309	transcriptional regulator
C5523_RS23875	COG0583	DNA-binding transcription factor activity
C5523_RS23880	COG2249	NAD(P)H dehydrogenase (quinone) activity
C5523_RS23890	COG0740	serine-type endopeptidase activity
C5523_RS23895	COG5457	Domain of unknown function (DUF1127)
C5523_RS23900	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C5523_RS23910	COG1917	Cupin 2, conserved barrel domain protein
C5523_RS23910	COG4977	sequence-specific DNA binding
C5523_RS23930	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C5523_RS23950	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C5523_RS23955	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C5523_RS23960	COG1120	ATPase activity
C5523_RS23965	COG4774	siderophore transport
C5523_RS23990	COG0814	amino acid
C5523_RS23995	COG2850	peptidyl-arginine hydroxylation
C5523_RS24020	COG1414	Transcriptional regulator
C5523_RS24025	COG3507	Belongs to the glycosyl hydrolase 43 family
C5523_RS24030	COG2211	Major facilitator Superfamily
C5523_RS24035	COG0129	dihydroxy-acid dehydratase activity
C5523_RS24085	COG2801	Transposase and inactivated derivatives
C5523_RS24135	COG1215	transferase activity, transferring glycosyl groups
C5523_RS24160	COG2003	Belongs to the UPF0758 family
C5523_RS24200	COG4735	regulation of single-species biofilm formation
C5523_RS24230	COG1061	Type III restriction enzyme res subunit
C5523_RS24245	COG1074	ATP-dependent DNA helicase activity
C5523_RS24255	COG0582	viral genome integration into host DNA
C5523_RS24275	COG1064	alcohol dehydrogenase
C5523_RS24285	COG0795	lipopolysaccharide-transporting ATPase activity
C5523_RS24290	COG0795	lipopolysaccharide-transporting ATPase activity
C5523_RS24295	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C5523_RS24300	COG2927	DNA polymerase III (CHI subunit)
C5523_RS24310	COG4269	membrane
C5523_RS24345	COG2188	Transcriptional regulator
C5523_RS24350	COG1288	antiporter activity
C5523_RS24355	COG1228	amidohydrolase
C5523_RS24360	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C5523_RS24365	COG2222	sugar isomerase
C5523_RS24370	COG2731	YhcH YjgK YiaL family protein
C5523_RS24405	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C5523_RS24415	COG1263	PTS System
C5523_RS24415	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C5523_RS24420	COG0366	Alpha amylase catalytic
C5523_RS24430	COG0602	queuosine metabolic process
C5523_RS24445	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C5523_RS24445	COG3711	transcriptional antiterminator
C5523_RS24460	COG3964	amidohydrolase
C5523_RS24500	COG3783	Cytochrome b(562)
C5523_RS24505	COG0312	modulator of DNA gyrase
C5523_RS24520	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C5523_RS24540	COG1172	Belongs to the binding-protein-dependent transport system permease family
C5523_RS24545	COG1172	Belongs to the binding-protein-dependent transport system permease family
C5523_RS24550	COG1129	ABC transporter
C5523_RS24555	COG1879	ABC-type sugar transport system periplasmic component
C5523_RS24565	COG0840	transmembrane signaling receptor activity
C5523_RS24575	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
C5523_RS24575	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
C5523_RS24580	COG2105	PFAM AIG2 family protein
C5523_RS24585	COG2911	Protein conserved in bacteria
C5523_RS24590	COG0729	surface antigen
C5523_RS24610	COG1253	flavin adenine dinucleotide binding
C5523_RS24620	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
C5523_RS24635	COG1733	regulation of RNA biosynthetic process
C5523_RS24640	COG0702	epimerase
C5523_RS24650	COG0697	spore germination
C5523_RS24660	COG1113	amino acid transport
C5523_RS24665	COG0545	Peptidyl-prolyl cis-trans isomerase
C5523_RS24670	COG3061	Opacity-associated protein A
C5523_RS24680	COG0359	binds to the 23S rRNA
C5523_RS24685	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C5523_RS24690	COG2965	DNA replication, synthesis of RNA primer
C5523_RS24750	COG1073	alpha beta
C5523_RS24755	COG3650	response to hydrogen peroxide
C5523_RS24770	COG1960	acyl-CoA dehydrogenase activity
C5523_RS24775	COG0477	Major facilitator Superfamily
C5523_RS24780	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C5523_RS24790	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C5523_RS24805	COG2515	1-aminocyclopropane-1-carboxylate deaminase
C5523_RS24810	COG0557	exoribonuclease II activity
C5523_RS24825	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
C5523_RS24830	COG0330	HflC and HflK could
C5523_RS24835	COG0330	HflC and HflK could
C5523_RS24840	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C5523_RS24845	COG1923	regulation of RNA biosynthetic process
C5523_RS24850	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C5523_RS24860	COG0860	N-Acetylmuramoyl-L-alanine amidase
C5523_RS24865	COG0802	atpase or kinase
C5523_RS24870	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C5523_RS24870	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C5523_RS24910	COG1511	domain protein
C5523_RS24910	COG3264	Mechanosensitive ion channel
C5523_RS24920	COG1053	succinate dehydrogenase
C5523_RS24925	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C5523_RS24940	COG3040	lipid binding
C5523_RS24970	COG1509	lysine 2,3-aminomutase activity
C5523_RS24980	COG0840	transmembrane signaling receptor activity
C5523_RS25000	COG0531	amino acid
C5523_RS25005	COG3030	protein affecting phage T7 exclusion by the F plasmid
C5523_RS25010	COG1027	Aspartate ammonia-lyase
C5523_RS25015	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
C5523_RS25030	COG1309	transcriptional regulator
C5523_RS25055	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
C5523_RS25080	COG2824	Alkylphosphonate utilization operon protein PhnA
C5523_RS25095	COG0326	Molecular chaperone. Has ATPase activity
C5523_RS25115	COG1129	ABC transporter
C5523_RS25120	COG1172	Belongs to the binding-protein-dependent transport system permease family
C5523_RS25135	COG0191	fructose-bisphosphate aldolase activity
C5523_RS25140	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C5523_RS25165	COG0346	lactoylglutathione lyase activity
C5523_RS25170	COG1349	DNA-binding transcription factor activity
C5523_RS25175	COG1301	dicarboxylic acid transport
C5523_RS25190	COG3162	membrane
C5523_RS25195	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C5523_RS25205	COG0673	inositol 2-dehydrogenase activity
C5523_RS25210	COG1346	cytolysis
C5523_RS25215	COG1380	Effector of murein hydrolase LrgA
C5523_RS25220	COG0583	DNA-binding transcription factor activity
C5523_RS25225	COG0025	NhaP-type Na H and K H
C5523_RS25230	COG2252	PERMEase
C5523_RS25235	COG0625	glutathione transferase activity
C5523_RS25250	COG4943	cyclic-guanylate-specific phosphodiesterase activity
C5523_RS25255	COG2199	diguanylate cyclase activity
C5523_RS25265	COG0629	single-stranded DNA binding
C5523_RS25275	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C5523_RS25280	COG2315	Protein conserved in bacteria
C5523_RS25285	COG0432	Pfam Uncharacterised protein family UPF0047
C5523_RS25290	COG3700	Belongs to the class B bacterial acid phosphatase family
C5523_RS25295	COG1448	Aminotransferase
C5523_RS25305	COG0305	Participates in initiation and elongation during chromosome replication
C5523_RS25340	COG0735	belongs to the Fur family
C5523_RS25345	COG3237	CsbD-like
C5523_RS25360	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C5523_RS25375	COG3161	chorismate lyase activity
C5523_RS25385	COG4580	involved in the transport of maltose and maltodextrins
C5523_RS25395	COG2182	Extracellular solute-binding protein
C5523_RS25415	COG3223	Belongs to the PsiE family
C5523_RS25425	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C5523_RS25430	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C5523_RS25455	COG0527	aspartate kinase activity
C5523_RS25460	COG3541	Predicted nucleotidyltransferase
C5523_RS25465	COG1690	Belongs to the RtcB family
C5523_RS25475	COG4650	regulator
C5523_RS25490	COG1187	pseudouridine synthase activity
C5523_RS25495	COG1283	sodium-dependent phosphate transmembrane transporter activity
C5523_RS25510	COG1760	l-serine dehydratase
C5523_RS25515	COG0814	amino acid
C5523_RS25560	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C5523_RS25570	COG0456	acetyltransferase
C5523_RS25610	COG0151	Belongs to the GarS family
C5523_RS25620	COG4191	Histidine kinase
C5523_RS25660	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
C5523_RS25670	COG0352	thiamine-phosphate diphosphorylase activity
C5523_RS25675	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C5523_RS25680	COG2104	thiamine diphosphate biosynthetic process
C5523_RS25695	COG3706	GGDEF domain
C5523_RS25705	COG1447	Phosphotransferase system cellobiose-specific component IIA
C5523_RS25745	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C5523_RS25765	COG0250	Participates in transcription elongation, termination and antitermination
C5523_RS25810	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C5523_RS25845	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
C5523_RS25855	COG1739	Uncharacterized protein family UPF0029
C5523_RS25900	COG0805	protein transport
C5523_RS25945	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
C5523_RS25955	COG4149	molybdate abc transporter
C5523_RS25960	COG1840	ABC-type Fe3 transport system, periplasmic component
C5523_RS25965	COG1349	DNA-binding transcription factor activity
C5523_RS25975	COG0583	DNA-binding transcription factor activity
C5523_RS25980	COG0697	spore germination
C5523_RS25985	COG0561	phosphatase activity
C5523_RS25990	COG2267	carboxylic ester hydrolase activity
C5523_RS25995	COG1280	lysine exporter protein (LysE YggA)
C5523_RS26000	COG1280	lysine exporter protein (LysE YggA)
C5523_RS26010	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
C5523_RS26030	COG0210	DNA helicase
C5523_RS26035	COG1011	Hydrolase
C5523_RS26085	COG2959	enzyme of heme biosynthesis
C5523_RS26090	COG3071	HemY protein
C5523_RS26140	COG2244	polysaccharide biosynthetic process
C5523_RS26145	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C5523_RS26150	COG0456	acetyltransferase
C5523_RS26155	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
C5523_RS26160	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
C5523_RS26170	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C5523_RS26175	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C5523_RS26180	COG3118	belongs to the thioredoxin family
C5523_RS26200	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C5523_RS26240	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C5523_RS26250	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C5523_RS26255	COG3978	acetolactate synthase activity
C5523_RS26275	COG3085	chromosome segregation
C5523_RS26360	COG0583	DNA-binding transcription factor activity
C5523_RS26380	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C5523_RS26390	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
C5523_RS26395	COG2207	Transcriptional regulator
C5523_RS26400	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C5523_RS26405	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C5523_RS26410	COG1882	Formate acetyltransferase
C5523_RS26415	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C5523_RS26420	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C5523_RS26425	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C5523_RS26425	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C5523_RS26425	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C5523_RS26435	COG0371	Dehydrogenase
C5523_RS26440	COG1349	DNA-binding transcription factor activity
C5523_RS26445	COG1882	Formate acetyltransferase
C5523_RS26455	COG0363	glucosamine-6-phosphate deaminase activity
C5523_RS26460	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C5523_RS26465	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C5523_RS26475	COG0460	homoserine dehydrogenase
C5523_RS26475	COG0527	aspartate kinase activity
C5523_RS26480	COG0626	cystathionine gamma-synthase activity
C5523_RS26490	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
C5523_RS26510	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C5523_RS26515	COG1609	Transcriptional regulator
C5523_RS26520	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C5523_RS26535	COG1575	Belongs to the MenA family. Type 1 subfamily
C5523_RS26540	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C5523_RS26545	COG3074	FtsZ-dependent cytokinesis
C5523_RS26550	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C5523_RS26555	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C5523_RS26560	COG1494	fructose-1,6-bisphosphatase
C5523_RS26570	COG3152	Membrane
C5523_RS26580	COG0149	triose-phosphate isomerase activity
C5523_RS26620	COG3678	ATP-independent chaperone mediated protein folding
C5523_RS26625	COG0745	RESPONSE REGULATOR receiver
C5523_RS26630	COG2205	protein histidine kinase activity
C5523_RS26635	COG2258	MOSC domain
C5523_RS26640	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C5523_RS26655	COG1917	Cupin 2, conserved barrel domain protein
C5523_RS26655	COG4977	sequence-specific DNA binding
C5523_RS26665	COG1070	Carbohydrate kinase
C5523_RS26675	COG0235	Class ii aldolase
C5523_RS26685	COG1129	ABC transporter
C5523_RS26690	COG1172	Belongs to the binding-protein-dependent transport system permease family
C5523_RS26700	COG1454	alcohol dehydrogenase
C5523_RS26710	COG2271	Major facilitator Superfamily
C5523_RS26715	COG2731	YhcH YjgK YiaL family protein
C5523_RS26720	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C5523_RS26725	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C5523_RS26735	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
C5523_RS26775	COG0205	6-phosphofructokinase activity
C5523_RS26805	COG3383	formate dehydrogenase (NAD+) activity
C5523_RS26805	COG0243	molybdopterin cofactor binding
C5523_RS26810	COG3383	formate dehydrogenase (NAD+) activity
C5523_RS26810	COG0243	molybdopterin cofactor binding
C5523_RS26815	COG0437	4 iron, 4 sulfur cluster binding
C5523_RS26820	COG2864	formate dehydrogenase
C5523_RS26835	COG0657	acetylesterase activity
C5523_RS26845	COG0456	acetyltransferase
C5523_RS26850	COG1490	D-aminoacyl-tRNA deacylase activity
C5523_RS26860	COG1011	Hydrolase
C5523_RS26880	COG3852	Histidine kinase
C5523_RS26890	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C5523_RS26910	COG0204	Acyl-transferase
C5523_RS26920	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C5523_RS26925	COG3084	Protein conserved in bacteria
C5523_RS26935	COG1763	Mo-molybdopterin cofactor biosynthetic process
C5523_RS26965	COG2186	Transcriptional regulator
C5523_RS26970	COG0477	Major facilitator Superfamily
C5523_RS26975	COG1609	Transcriptional regulator
C5523_RS26980	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C5523_RS26985	COG1879	ABC-type sugar transport system periplasmic component
C5523_RS26990	COG1172	Belongs to the binding-protein-dependent transport system permease family
C5523_RS26995	COG1129	ABC transporter
C5523_RS27000	COG1869	D-ribose catabolic process
C5523_RS27025	COG1522	sequence-specific DNA binding
C5523_RS27030	COG0716	FMN binding
C5523_RS27045	COG3312	ion transport
C5523_RS27105	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C5523_RS27110	COG0573	inorganic phosphate transmembrane transporter activity
C5523_RS27115	COG0581	inorganic phosphate transmembrane transporter activity
C5523_RS27125	COG0704	Plays a role in the regulation of phosphate uptake
C5523_RS27135	COG2382	esterase
C5523_RS27140	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C5523_RS27145	COG2252	PERMEase
C5523_RS27150	COG0431	NADPH-dependent FMN reductase
C5523_RS27155	COG2091	lysine biosynthetic process via aminoadipic acid
C5523_RS27165	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C5523_RS27170	COG0706	membrane insertase activity
C5523_RS27175	COG0759	Could be involved in insertion of integral membrane proteins into the membrane