locus-tag	class	description
GW538_RS00010	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GW538_RS00015	COG0706	membrane insertase activity
GW538_RS00020	COG0594	ribonuclease P activity
GW538_RS00025	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GW538_RS00040	COG1192	Involved in chromosome partitioning
GW538_RS00045	COG1475	DNA binding
GW538_RS00055	COG0356	it plays a direct role in the translocation of protons across the membrane
GW538_RS00065	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GW538_RS00070	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GW538_RS00080	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GW538_RS00085	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GW538_RS00095	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GW538_RS00100	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GW538_RS00145	COG0489	protein tyrosine kinase activity
GW538_RS00165	COG3385	transposase activity
GW538_RS00175	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS00190	COG0517	IMP dehydrogenase activity
GW538_RS00190	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GW538_RS00200	COG2226	methyltransferase
GW538_RS00200	COG2867	negative regulation of translational initiation
GW538_RS00215	COG2814	Major facilitator Superfamily
GW538_RS00235	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GW538_RS00240	COG0109	protoheme IX farnesyltransferase activity
GW538_RS00250	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GW538_RS00275	COG3385	transposase activity
GW538_RS00305	COG3385	transposase activity
GW538_RS00335	COG4221	oxidoreductase activity
GW538_RS00355	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GW538_RS00365	COG0189	ligase activity
GW538_RS00370	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GW538_RS00375	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GW538_RS00395	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GW538_RS00415	COG1678	Uncharacterized ACR, COG1678
GW538_RS00420	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GW538_RS00450	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GW538_RS00455	COG0281	malic enzyme
GW538_RS00465	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GW538_RS00475	COG4221	oxidoreductase activity
GW538_RS00515	COG0489	protein tyrosine kinase activity
GW538_RS00515	COG3206	protein involved in exopolysaccharide biosynthesis
GW538_RS00520	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GW538_RS00535	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GW538_RS00545	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GW538_RS00550	COG1215	transferase activity, transferring glycosyl groups
GW538_RS00560	COG0297	glycogen (starch) synthase activity
GW538_RS00565	COG0438	transferase activity, transferring glycosyl groups
GW538_RS00580	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GW538_RS00590	COG2885	chlorophyll binding
GW538_RS00590	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
GW538_RS00595	COG1278	Cold shock
GW538_RS00600	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GW538_RS00605	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS00610	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GW538_RS00615	COG0745	RESPONSE REGULATOR receiver
GW538_RS00635	COG0181	hydroxymethylbilane synthase activity
GW538_RS00685	COG0583	DNA-binding transcription factor activity
GW538_RS00700	COG0210	DNA helicase
GW538_RS00710	COG0531	amino acid
GW538_RS00720	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GW538_RS00730	COG0318	PFAM AMP-dependent synthetase and ligase
GW538_RS00745	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GW538_RS00750	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GW538_RS00810	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GW538_RS00815	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GW538_RS00820	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
GW538_RS00845	COG2027	D-alanyl-D-alanine carboxypeptidase
GW538_RS00850	COG2027	D-alanyl-D-alanine carboxypeptidase
GW538_RS00865	COG0210	DNA helicase
GW538_RS00880	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GW538_RS00890	COG0788	formyltetrahydrofolate deformylase activity
GW538_RS00920	COG0259	pyridoxamine-phosphate oxidase activity
GW538_RS00950	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GW538_RS00970	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GW538_RS00975	COG2119	membrane
GW538_RS00995	COG3385	transposase activity
GW538_RS01025	COG1534	Rna-binding protein
GW538_RS01035	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
GW538_RS01040	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GW538_RS01045	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GW538_RS01055	COG0508	dehydrogenase complex catalyzes the overall conversion of
GW538_RS01060	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GW538_RS01085	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GW538_RS01090	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GW538_RS01095	COG0511	ligase activity, forming carbon-carbon bonds
GW538_RS01100	COG0439	Biotin carboxylase
GW538_RS01115	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
GW538_RS01120	COG0138	bifunctional purine biosynthesis protein purh
GW538_RS01125	COG0151	Belongs to the GarS family
GW538_RS01130	COG0006	proline dipeptidase activity
GW538_RS01150	COG0745	RESPONSE REGULATOR receiver
GW538_RS01155	COG0531	amino acid
GW538_RS01175	COG2925	Exonuclease
GW538_RS01185	COG2011	ABC-type metal ion transport system permease component
GW538_RS01205	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GW538_RS01210	COG2070	2-Nitropropane dioxygenase
GW538_RS01215	COG0586	Pfam SNARE associated Golgi protein
GW538_RS01220	COG4536	flavin adenine dinucleotide binding
GW538_RS01225	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GW538_RS01230	COG2995	paraquat-inducible protein a
GW538_RS01260	COG1301	dicarboxylic acid transport
GW538_RS01270	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
GW538_RS01290	COG3385	transposase activity
GW538_RS01295	COG3104	oligopeptide transport
GW538_RS01300	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
GW538_RS01345	COG3385	transposase activity
GW538_RS01365	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS01380	COG3385	transposase activity
GW538_RS01425	COG1183	phosphatidylcholine synthase activity
GW538_RS01435	COG0456	acetyltransferase
GW538_RS01445	COG0084	hydrolase, TatD family'
GW538_RS01455	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GW538_RS01515	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GW538_RS01540	COG3385	transposase activity
GW538_RS01550	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GW538_RS01560	COG1773	rubredoxin
GW538_RS01570	COG0316	Belongs to the HesB IscA family
GW538_RS01580	COG3385	transposase activity
GW538_RS01610	COG0084	hydrolase, TatD family'
GW538_RS01625	COG1028	Short-chain dehydrogenase reductase Sdr
GW538_RS01640	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GW538_RS01645	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GW538_RS01660	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS01665	COG3385	transposase activity
GW538_RS01675	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GW538_RS01685	COG0833	amino acid
GW538_RS01695	COG3385	transposase activity
GW538_RS01705	COG3385	transposase activity
GW538_RS01715	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS01735	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GW538_RS01745	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS01770	COG3385	transposase activity
GW538_RS01785	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GW538_RS01875	COG2205	protein histidine kinase activity
GW538_RS01885	COG0500	methyltransferase
GW538_RS01915	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS01925	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS01930	COG0308	aminopeptidase N
GW538_RS01940	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GW538_RS01945	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
GW538_RS01950	COG3385	transposase activity
GW538_RS01970	COG1113	amino acid transport
GW538_RS01995	COG0837	glucose binding
GW538_RS02005	COG3852	Histidine kinase
GW538_RS02015	COG1677	Flagellar hook-basal body complex protein FliE
GW538_RS02025	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GW538_RS02070	COG2009	succinate dehydrogenase
GW538_RS02075	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
GW538_RS02080	COG1053	succinate dehydrogenase
GW538_RS02085	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GW538_RS02100	COG0045	succinate-CoA ligase (ADP-forming) activity
GW538_RS02120	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS02145	COG1918	ferrous iron import across plasma membrane
GW538_RS02150	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GW538_RS02160	COG0625	glutathione transferase activity
GW538_RS02165	COG2969	positive regulation of protein catabolic process
GW538_RS02170	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GW538_RS02175	COG0792	nuclease activity
GW538_RS02185	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GW538_RS02190	COG0142	geranyltranstransferase activity
GW538_RS02195	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GW538_RS02205	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GW538_RS02210	COG0840	transmembrane signaling receptor activity
GW538_RS02220	COG1509	lysine 2,3-aminomutase activity
GW538_RS02225	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GW538_RS02230	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
GW538_RS02255	COG0438	transferase activity, transferring glycosyl groups
GW538_RS02260	COG0436	Aminotransferase
GW538_RS02265	COG0556	nucleotide-excision repair
GW538_RS02285	COG1086	Polysaccharide biosynthesis protein
GW538_RS02290	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GW538_RS02295	COG1083	cytidylyl-transferase
GW538_RS02305	COG2089	acid synthase
GW538_RS02325	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GW538_RS02335	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GW538_RS02350	COG0072	phenylalanine-tRNA ligase activity
GW538_RS02390	COG0069	glutamate synthase activity
GW538_RS02420	COG3385	transposase activity
GW538_RS02450	COG2818	Glycosylase
GW538_RS02510	COG0728	peptidoglycan biosynthetic process
GW538_RS02515	COG0196	riboflavin kinase activity
GW538_RS02520	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS02525	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GW538_RS02530	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GW538_RS02535	COG1047	Peptidyl-prolyl cis-trans
GW538_RS02540	COG2271	Major facilitator Superfamily
GW538_RS02550	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GW538_RS02555	COG0840	transmembrane signaling receptor activity
GW538_RS02565	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS02600	COG1051	belongs to the nudix hydrolase family
GW538_RS02625	COG3385	transposase activity
GW538_RS02640	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS02670	COG0735	belongs to the Fur family
GW538_RS02675	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GW538_RS02685	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GW538_RS02690	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GW538_RS02695	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GW538_RS02725	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS02750	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
GW538_RS02830	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GW538_RS02835	COG2814	Major facilitator Superfamily
GW538_RS02840	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
GW538_RS02845	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GW538_RS02865	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS02900	COG0307	riboflavin synthase, alpha
GW538_RS02905	COG0189	ligase activity
GW538_RS02925	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS02930	COG3385	transposase activity
GW538_RS02935	COG2177	Part of the ABC transporter FtsEX involved in
GW538_RS02940	COG2884	Cell division ATP-binding protein ftsE
GW538_RS02955	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GW538_RS02960	COG3385	transposase activity
GW538_RS02980	COG0205	6-phosphofructokinase activity
GW538_RS02990	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GW538_RS03010	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS03025	COG0546	phosphoglycolate phosphatase activity
GW538_RS03040	COG2350	Protein conserved in bacteria
GW538_RS03045	COG2917	probably involved in intracellular septation
GW538_RS03050	COG0009	L-threonylcarbamoyladenylate synthase
GW538_RS03060	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GW538_RS03100	COG0739	heme binding
GW538_RS03105	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GW538_RS03115	COG0670	Belongs to the BI1 family
GW538_RS03120	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GW538_RS03135	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GW538_RS03160	COG2963	transposase activity
GW538_RS03175	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS03190	COG2801	Transposase and inactivated derivatives
GW538_RS03195	COG2801	Transposase and inactivated derivatives
GW538_RS03205	COG2963	transposase activity
GW538_RS03230	COG3240	lipase activity
GW538_RS03235	COG3385	transposase activity
GW538_RS03255	COG0742	ribosomal rna small subunit methyltransferase
GW538_RS03260	COG1760	l-serine dehydratase
GW538_RS03290	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GW538_RS03295	COG3273	potassium ion transport
GW538_RS03295	COG0471	metal ion transport
GW538_RS03320	COG3385	transposase activity
GW538_RS03345	COG0166	Belongs to the GPI family
GW538_RS03355	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GW538_RS03360	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GW538_RS03390	COG3385	transposase activity
GW538_RS03410	COG3385	transposase activity
GW538_RS03415	COG2814	Major facilitator Superfamily
GW538_RS03420	COG0156	8-amino-7-oxononanoate synthase activity
GW538_RS03435	COG0179	Fumarylacetoacetate (FAA) hydrolase
GW538_RS03440	COG0835	chemotaxis
GW538_RS03440	COG0784	Response regulator, receiver
GW538_RS03445	COG0835	chemotaxis
GW538_RS03445	COG0784	Response regulator, receiver
GW538_RS03485	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GW538_RS03495	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GW538_RS03500	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GW538_RS03510	COG2183	response to ionizing radiation
GW538_RS03530	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GW538_RS03535	COG2871	sodium ion transport
GW538_RS03540	COG1438	arginine binding
GW538_RS03610	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS03615	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GW538_RS03620	COG0154	amidase activity
GW538_RS03625	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GW538_RS03630	COG1077	Cell shape determining protein MreB Mrl
GW538_RS03635	COG1792	Involved in formation and maintenance of cell shape
GW538_RS03645	COG0424	maF-like protein
GW538_RS03650	COG1530	ribonuclease E activity
GW538_RS03660	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GW538_RS03670	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS03675	COG3385	transposase activity
GW538_RS03680	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS03690	COG2171	N-acyltransferase activity
GW538_RS03695	COG0252	asparaginase activity
GW538_RS03700	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GW538_RS03710	COG0052	Belongs to the universal ribosomal protein uS2 family
GW538_RS03715	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GW538_RS03720	COG0528	UMP kinase activity
GW538_RS03725	COG0233	cytoplasmic translational termination
GW538_RS03730	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GW538_RS03735	COG0575	Belongs to the CDS family
GW538_RS03760	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
GW538_RS03775	COG3425	synthase
GW538_RS03795	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GW538_RS03800	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GW538_RS03805	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GW538_RS03810	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GW538_RS03815	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GW538_RS03820	COG0587	DNA-directed DNA polymerase activity
GW538_RS03825	COG0825	malonyl-CoA metabolic process
GW538_RS03830	COG0037	tRNA processing
GW538_RS03835	COG0659	secondary active sulfate transmembrane transporter activity
GW538_RS03840	COG3385	transposase activity
GW538_RS03855	COG3385	transposase activity
GW538_RS03860	COG3385	transposase activity
GW538_RS03865	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS03900	COG2223	nitrite transmembrane transporter activity
GW538_RS03915	COG3385	transposase activity
GW538_RS03945	COG3385	transposase activity
GW538_RS04040	COG0351	phosphomethylpyrimidine kinase
GW538_RS04065	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
GW538_RS04075	COG1566	PFAM secretion protein HlyD family protein
GW538_RS04080	COG2814	Major facilitator Superfamily
GW538_RS04085	COG1538	Outer membrane efflux protein
GW538_RS04090	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GW538_RS04100	COG2197	response regulator
GW538_RS04135	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS04145	COG2963	transposase activity
GW538_RS04185	COG3335	DDE superfamily endonuclease
GW538_RS04205	COG2801	Transposase and inactivated derivatives
GW538_RS04225	COG3385	transposase activity
GW538_RS04245	COG0656	L-ascorbic acid biosynthetic process
GW538_RS04255	COG0477	Major facilitator Superfamily
GW538_RS04260	COG0235	Class ii aldolase
GW538_RS04270	COG0626	cystathionine gamma-synthase activity
GW538_RS04280	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GW538_RS04295	COG0544	peptidyl-prolyl cis-trans isomerase activity
GW538_RS04300	COG0740	serine-type endopeptidase activity
GW538_RS04310	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GW538_RS04325	COG1560	Kdo2-lipid A biosynthetic process
GW538_RS04330	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GW538_RS04340	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GW538_RS04345	COG2274	protein secretion by the type I secretion system
GW538_RS04350	COG2274	protein secretion by the type I secretion system
GW538_RS04355	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GW538_RS04365	COG1686	Belongs to the peptidase S11 family
GW538_RS04395	COG3385	transposase activity
GW538_RS04400	COG2801	Transposase and inactivated derivatives
GW538_RS04440	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS04445	COG0187	DNA topoisomerase II activity
GW538_RS04455	COG3385	transposase activity
GW538_RS04465	COG3385	transposase activity
GW538_RS04515	COG0776	regulation of translation
GW538_RS04525	COG3385	transposase activity
GW538_RS04535	COG0039	L-malate dehydrogenase activity
GW538_RS04540	COG1538	Outer membrane efflux protein
GW538_RS04545	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GW538_RS04550	COG3150	esterase
GW538_RS04555	COG4988	ABC transporter
GW538_RS04560	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GW538_RS04590	COG3104	oligopeptide transport
GW538_RS04595	COG3385	transposase activity
GW538_RS04600	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS04650	COG1546	Belongs to the CinA family
GW538_RS04650	COG1058	Belongs to the CinA family
GW538_RS04675	COG3385	transposase activity
GW538_RS04690	COG4948	Mandelate Racemase Muconate Lactonizing
GW538_RS04700	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GW538_RS04705	COG0450	alkyl hydroperoxide reductase
GW538_RS04715	COG0500	methyltransferase
GW538_RS04720	COG3385	transposase activity
GW538_RS04740	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS04760	COG3385	transposase activity
GW538_RS04780	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GW538_RS04795	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GW538_RS04805	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS04870	COG3385	transposase activity
GW538_RS04930	COG0358	DNA primase activity
GW538_RS04935	COG1610	YqeY-like protein
GW538_RS04940	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GW538_RS04945	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GW538_RS04950	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GW538_RS04965	COG3385	transposase activity
GW538_RS04975	COG3385	transposase activity
GW538_RS04980	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS05000	COG1621	beta-fructofuranosidase activity
GW538_RS05025	COG0259	pyridoxamine-phosphate oxidase activity
GW538_RS05030	COG0589	response to stress
GW538_RS05040	COG1228	amidohydrolase
GW538_RS05050	COG2986	histidine ammonia-lyase
GW538_RS05085	COG3385	transposase activity
GW538_RS05105	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GW538_RS05110	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GW538_RS05120	COG3956	TIGRFAM MazG family protein
GW538_RS05125	COG3956	TIGRFAM MazG family protein
GW538_RS05135	COG0563	adenylate kinase activity
GW538_RS05140	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GW538_RS05145	COG2223	nitrite transmembrane transporter activity
GW538_RS05160	COG1278	Cold shock
GW538_RS05165	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GW538_RS05170	COG0542	response to heat
GW538_RS05175	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GW538_RS05185	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS05200	COG0492	ferredoxin-NADP+ reductase activity
GW538_RS05220	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
GW538_RS05225	COG1104	cysteine desulfurase activity
GW538_RS05235	COG0105	UTP biosynthetic process
GW538_RS05240	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GW538_RS05260	COG0124	histidyl-tRNA synthetase
GW538_RS05270	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GW538_RS05275	COG1160	GTP binding
GW538_RS05300	COG1192	Involved in chromosome partitioning
GW538_RS05310	COG0835	chemotaxis
GW538_RS05325	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS05345	COG2201	protein-glutamate methylesterase activity
GW538_RS05355	COG1530	ribonuclease E activity
GW538_RS05365	COG2918	glutathione biosynthetic process
GW538_RS05370	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GW538_RS05375	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GW538_RS05380	COG0632	four-way junction helicase activity
GW538_RS05390	COG0811	peptide transport
GW538_RS05405	COG0823	Involved in the tonB-independent uptake of proteins
GW538_RS05415	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
GW538_RS05420	COG0602	queuosine metabolic process
GW538_RS05440	COG1570	exodeoxyribonuclease VII activity
GW538_RS05445	COG1131	(ABC) transporter
GW538_RS05450	COG0842	Transport permease protein
GW538_RS05460	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS05470	COG0442	prolyl-tRNA aminoacylation
GW538_RS05475	COG3385	transposase activity
GW538_RS05495	COG3385	transposase activity
GW538_RS05540	COG3385	transposase activity
GW538_RS05545	COG2204	response regulator
GW538_RS05565	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GW538_RS05570	COG0616	signal peptide processing
GW538_RS05575	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GW538_RS05625	COG3385	transposase activity
GW538_RS05650	COG3385	transposase activity
GW538_RS05655	COG1012	belongs to the aldehyde dehydrogenase family
GW538_RS05665	COG2205	protein histidine kinase activity
GW538_RS05665	COG0784	Response regulator, receiver
GW538_RS05665	COG5002	protein histidine kinase activity
GW538_RS05690	COG0183	Belongs to the thiolase family
GW538_RS05695	COG1250	3-hydroxyacyl-CoA dehydrogenase
GW538_RS05695	COG1024	Enoyl-CoA hydratase
GW538_RS05710	COG1472	Belongs to the glycosyl hydrolase 3 family
GW538_RS05715	COG0668	transmembrane transport
GW538_RS05720	COG0598	Magnesium transport protein CorA
GW538_RS05725	COG0318	PFAM AMP-dependent synthetase and ligase
GW538_RS05735	COG0527	aspartate kinase activity
GW538_RS05735	COG0460	homoserine dehydrogenase
GW538_RS05745	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GW538_RS05760	COG2801	Transposase and inactivated derivatives
GW538_RS05765	COG2801	Transposase and inactivated derivatives
GW538_RS05770	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GW538_RS05780	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GW538_RS05880	COG1181	Belongs to the D-alanine--D-alanine ligase family
GW538_RS05905	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GW538_RS05915	COG0564	pseudouridine synthase activity
GW538_RS05920	COG1335	isochorismatase
GW538_RS05925	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GW538_RS05960	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GW538_RS05975	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS05990	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS06000	COG0288	reversible hydration of carbon dioxide
GW538_RS06005	COG2814	Major facilitator Superfamily
GW538_RS06010	COG0525	valine-tRNA ligase activity
GW538_RS06020	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GW538_RS06025	COG0795	lipopolysaccharide-transporting ATPase activity
GW538_RS06035	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GW538_RS06045	COG1862	Preprotein translocase
GW538_RS06050	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GW538_RS06055	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GW538_RS06070	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GW538_RS06075	COG1876	peptidase activity
GW538_RS06080	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GW538_RS06090	COG1090	epimerase
GW538_RS06115	COG2801	Transposase and inactivated derivatives
GW538_RS06120	COG3385	transposase activity
GW538_RS06185	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
GW538_RS06190	COG2894	cell division
GW538_RS06210	COG0733	neurotransmitter:sodium symporter activity
GW538_RS06215	COG0708	Exodeoxyribonuclease III
GW538_RS06245	COG3385	transposase activity
GW538_RS06275	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GW538_RS06280	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GW538_RS06285	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GW538_RS06300	COG0326	Molecular chaperone. Has ATPase activity
GW538_RS06350	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GW538_RS06350	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GW538_RS06375	COG3385	transposase activity
GW538_RS06405	COG3385	transposase activity
GW538_RS06430	COG2801	Transposase and inactivated derivatives
GW538_RS06440	COG3385	transposase activity
GW538_RS06450	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS06485	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GW538_RS06485	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GW538_RS06495	COG3655	Transcriptional regulator
GW538_RS06510	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GW538_RS06515	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GW538_RS06525	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GW538_RS06565	COG2805	Type II/IV secretion system protein
GW538_RS06665	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
GW538_RS06670	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GW538_RS06675	COG1294	oxidase, subunit
GW538_RS06685	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
GW538_RS06685	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GW538_RS06690	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GW538_RS06690	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
GW538_RS06720	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
GW538_RS06735	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GW538_RS06765	COG0730	response to heat
GW538_RS06770	COG1671	Belongs to the UPF0178 family
GW538_RS06775	COG0688	phosphatidylethanolamine metabolic process
GW538_RS06780	COG1162	GTPase activity
GW538_RS06790	COG0802	atpase or kinase
GW538_RS06800	COG0783	Belongs to the Dps family
GW538_RS06805	COG0753	catalase activity
GW538_RS06810	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
GW538_RS06830	COG2801	Transposase and inactivated derivatives
GW538_RS06840	COG3385	transposase activity
GW538_RS06850	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS06865	COG3385	transposase activity
GW538_RS06875	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS06885	COG0488	(ABC) transporter
GW538_RS06895	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
GW538_RS06905	COG0101	tRNA pseudouridine synthase activity
GW538_RS06910	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GW538_RS06915	COG0285	dihydrofolate synthase activity
GW538_RS06920	COG1286	toxin biosynthetic process
GW538_RS06935	COG0405	Gamma-glutamyltransferase
GW538_RS06950	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GW538_RS06960	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GW538_RS06975	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GW538_RS07010	COG0531	amino acid
GW538_RS07015	COG0584	glycerophosphoryl diester phosphodiesterase
GW538_RS07020	COG2271	Major facilitator Superfamily
GW538_RS07025	COG1923	regulation of RNA biosynthetic process
GW538_RS07030	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GW538_RS07035	COG0330	HflC and HflK could
GW538_RS07040	COG0330	HflC and HflK could
GW538_RS07045	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GW538_RS07050	COG2252	PERMEase
GW538_RS07055	COG0557	exoribonuclease II activity
GW538_RS07060	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GW538_RS07095	COG2801	Transposase and inactivated derivatives
GW538_RS07120	COG1120	ATPase activity
GW538_RS07125	COG0019	diaminopimelate decarboxylase activity
GW538_RS07135	COG2814	Major facilitator Superfamily
GW538_RS07145	COG1181	Belongs to the D-alanine--D-alanine ligase family
GW538_RS07150	COG4772	TonB-dependent receptor
GW538_RS07155	COG0811	peptide transport
GW538_RS07175	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GW538_RS07190	COG3385	transposase activity
GW538_RS07205	COG1902	pentaerythritol trinitrate reductase activity
GW538_RS07205	COG0446	pyridine nucleotide-disulphide oxidoreductase
GW538_RS07215	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GW538_RS07225	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GW538_RS07230	COG0336	Belongs to the RNA methyltransferase TrmD family
GW538_RS07235	COG0335	large ribosomal subunit rRNA binding
GW538_RS07265	COG2801	Transposase and inactivated derivatives
GW538_RS07290	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS07310	COG3385	transposase activity
GW538_RS07320	COG2801	Transposase and inactivated derivatives
GW538_RS07355	COG3385	transposase activity
GW538_RS07370	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GW538_RS07375	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
GW538_RS07380	COG0504	CTP synthase activity
GW538_RS07385	COG2877	3-deoxy-8-phosphooctulonate synthase activity
GW538_RS07390	COG0148	phosphopyruvate hydratase activity
GW538_RS07395	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
GW538_RS07400	COG0585	pseudouridine synthase activity
GW538_RS07405	COG0531	amino acid
GW538_RS07410	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GW538_RS07415	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GW538_RS07420	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GW538_RS07440	COG3385	transposase activity
GW538_RS07495	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS07500	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GW538_RS07505	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GW538_RS07510	COG1845	cytochrome c oxidase, subunit III
GW538_RS07515	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GW538_RS07560	COG3104	oligopeptide transport
GW538_RS07575	COG2814	Major facilitator Superfamily
GW538_RS07585	COG0814	amino acid
GW538_RS07595	COG2840	Smr protein MutS2
GW538_RS07605	COG2890	protein-(glutamine-N5) methyltransferase activity
GW538_RS07610	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GW538_RS07615	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GW538_RS07650	COG0095	Lipoate-protein ligase
GW538_RS07655	COG0095	Lipoate-protein ligase
GW538_RS07660	COG0739	heme binding
GW538_RS07680	COG0488	(ABC) transporter
GW538_RS07690	COG0741	lytic transglycosylase activity
GW538_RS07690	COG1388	LysM domain
GW538_RS07725	COG1987	bacterial-type flagellum assembly
GW538_RS07740	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GW538_RS07765	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
GW538_RS07770	COG0784	Response regulator, receiver
GW538_RS07770	COG0643	Histidine kinase
GW538_RS07770	COG2198	Histidine kinase
GW538_RS07790	COG1959	2 iron, 2 sulfur cluster binding
GW538_RS07795	COG0719	Fe-S assembly protein
GW538_RS07800	COG0396	ATPase activity
GW538_RS07805	COG0719	Fe-S assembly protein
GW538_RS07810	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GW538_RS07815	COG0316	Belongs to the HesB IscA family
GW538_RS07830	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS07850	COG0572	uridine kinase
GW538_RS07855	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GW538_RS07915	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS07920	COG0686	Belongs to the AlaDH PNT family
GW538_RS07970	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GW538_RS07975	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
GW538_RS08000	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS08025	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GW538_RS08030	COG0477	Major facilitator Superfamily
GW538_RS08070	COG3385	transposase activity
GW538_RS08080	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GW538_RS08135	COG2801	Transposase and inactivated derivatives
GW538_RS08160	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS08175	COG0475	glutathione-regulated potassium exporter activity
GW538_RS08175	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GW538_RS08200	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS08205	COG1115	amino acid carrier protein
GW538_RS08210	COG0740	serine-type endopeptidase activity
GW538_RS08220	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GW538_RS08230	COG1663	tetraacyldisaccharide 4'-kinase activity
GW538_RS08235	COG1132	(ABC) transporter
GW538_RS08240	COG0848	biopolymer transport protein
GW538_RS08245	COG0811	peptide transport
GW538_RS08260	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS08280	COG2801	Transposase and inactivated derivatives
GW538_RS08315	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS08320	COG0658	competence protein
GW538_RS08320	COG2333	competence protein COMEC
GW538_RS08335	COG0583	DNA-binding transcription factor activity
GW538_RS08365	COG0513	Belongs to the DEAD box helicase family
GW538_RS08370	COG2866	Carboxypeptidase
GW538_RS08380	COG2095	MarC family integral membrane protein
GW538_RS08400	COG1280	lysine exporter protein (LysE YggA)
GW538_RS08415	COG0515	serine threonine protein kinase
GW538_RS08415	COG2815	serine threonine protein kinase
GW538_RS08440	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GW538_RS08445	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GW538_RS08450	COG2814	Major facilitator Superfamily
GW538_RS08470	COG2801	Transposase and inactivated derivatives
GW538_RS08500	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS08540	COG3064	Membrane
GW538_RS08540	COG4991	sh3 domain protein
GW538_RS08540	COG0515	serine threonine protein kinase
GW538_RS08550	COG0659	secondary active sulfate transmembrane transporter activity
GW538_RS08565	COG0741	lytic transglycosylase activity
GW538_RS08575	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS08590	COG0513	Belongs to the DEAD box helicase family
GW538_RS08645	COG0590	tRNA wobble adenosine to inosine editing
GW538_RS08675	COG2801	Transposase and inactivated derivatives
GW538_RS08690	COG3385	transposase activity
GW538_RS08695	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GW538_RS08695	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GW538_RS08710	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS08720	COG1294	oxidase, subunit
GW538_RS08765	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
GW538_RS08805	COG3385	transposase activity
GW538_RS08825	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GW538_RS08835	COG2801	Transposase and inactivated derivatives
GW538_RS08865	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GW538_RS08870	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GW538_RS08875	COG0784	Response regulator, receiver
GW538_RS08875	COG0835	chemotaxis
GW538_RS08880	COG0596	Alpha beta hydrolase
GW538_RS08890	COG1643	Atp-dependent helicase
GW538_RS08905	COG2070	2-Nitropropane dioxygenase
GW538_RS08950	COG2963	transposase activity
GW538_RS08955	COG0784	Response regulator, receiver
GW538_RS08955	COG0835	chemotaxis
GW538_RS08975	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
GW538_RS08975	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GW538_RS09015	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GW538_RS09015	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
GW538_RS09040	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GW538_RS09045	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GW538_RS09050	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GW538_RS09060	COG0729	surface antigen
GW538_RS09075	COG1376	ErfK ybiS ycfS ynhG family protein
GW538_RS09215	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS09225	COG3385	transposase activity
GW538_RS09260	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GW538_RS09265	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GW538_RS09270	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
GW538_RS09310	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GW538_RS09325	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GW538_RS09330	COG2081	HI0933 family
GW538_RS09335	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GW538_RS09345	COG1024	Enoyl-CoA hydratase
GW538_RS09355	COG3501	Rhs element vgr protein
GW538_RS09370	COG1960	acyl-CoA dehydrogenase activity
GW538_RS09375	COG0183	Belongs to the thiolase family
GW538_RS09380	COG1024	Enoyl-CoA hydratase
GW538_RS09380	COG1250	3-hydroxyacyl-CoA dehydrogenase
GW538_RS09440	COG2957	Belongs to the agmatine deiminase family
GW538_RS09445	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GW538_RS09455	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GW538_RS09490	COG0717	Belongs to the dCTP deaminase family
GW538_RS09515	COG3385	transposase activity
GW538_RS09555	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS09590	COG0564	pseudouridine synthase activity
GW538_RS09650	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS09690	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GW538_RS09715	COG3385	transposase activity
GW538_RS09795	COG3385	transposase activity
GW538_RS09820	COG1256	bacterial-type flagellum assembly
GW538_RS09820	COG4786	Flagellar basal body rod
GW538_RS09830	COG1706	bacterial-type flagellum-dependent cell motility
GW538_RS09840	COG4786	Flagellar basal body rod
GW538_RS09845	COG4787	bacterial-type flagellum-dependent cell motility
GW538_RS09850	COG1749	Flagellar hook protein flgE
GW538_RS09855	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GW538_RS09885	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GW538_RS09890	COG0482	sulfurtransferase activity
GW538_RS09895	COG3385	transposase activity
GW538_RS09905	COG2022	thiamine diphosphate biosynthetic process
GW538_RS09920	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GW538_RS09930	COG0531	amino acid
GW538_RS09945	COG0642	Histidine kinase
GW538_RS09980	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS09995	COG1393	Belongs to the ArsC family
GW538_RS10000	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GW538_RS10005	COG2066	Belongs to the glutaminase family
GW538_RS10010	COG0736	holo-[acyl-carrier-protein] synthase activity
GW538_RS10015	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GW538_RS10020	COG1381	Involved in DNA repair and RecF pathway recombination
GW538_RS10040	COG0681	Belongs to the peptidase S26 family
GW538_RS10050	COG1595	DNA-templated transcription, initiation
GW538_RS10065	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
GW538_RS10150	COG0583	DNA-binding transcription factor activity
GW538_RS10155	COG1199	ATP-dependent helicase activity
GW538_RS10190	COG4520	surface antigen
GW538_RS10210	COG0305	Participates in initiation and elongation during chromosome replication
GW538_RS10215	COG0359	binds to the 23S rRNA
GW538_RS10220	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GW538_RS10225	COG0360	Binds together with S18 to 16S ribosomal RNA
GW538_RS10240	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GW538_RS10245	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GW538_RS10250	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GW538_RS10255	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GW538_RS10265	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
GW538_RS10290	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS10325	COG3385	transposase activity
GW538_RS10340	COG1074	ATP-dependent DNA helicase activity
GW538_RS10350	COG2814	Major facilitator Superfamily
GW538_RS10365	COG3385	transposase activity
GW538_RS10420	COG1360	Flagellar Motor Protein
GW538_RS10425	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GW538_RS10430	COG0142	geranyltranstransferase activity
GW538_RS10435	COG1469	GTP cyclohydrolase I activity
GW538_RS10470	COG2801	Transposase and inactivated derivatives
GW538_RS10485	COG3385	transposase activity
GW538_RS10510	COG2963	transposase activity
GW538_RS10525	COG2801	Transposase and inactivated derivatives
GW538_RS10585	COG1366	Belongs to the anti-sigma-factor antagonist family
GW538_RS10600	COG2304	oxidoreductase activity
GW538_RS10605	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS10625	COG0714	Associated with various cellular activities
GW538_RS10630	COG0604	alcohol dehydrogenase
GW538_RS10680	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS10710	COG3385	transposase activity
GW538_RS10715	COG2801	Transposase and inactivated derivatives
GW538_RS10790	COG0189	ligase activity
GW538_RS10795	COG1131	(ABC) transporter
GW538_RS10860	COG0784	Response regulator, receiver
GW538_RS10860	COG0835	chemotaxis
GW538_RS10875	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS10880	COG3385	transposase activity
GW538_RS10900	COG2860	membrane
GW538_RS10915	COG2166	iron-sulfur cluster assembly
GW538_RS10955	COG2205	protein histidine kinase activity
GW538_RS10960	COG0745	RESPONSE REGULATOR receiver
GW538_RS10980	COG0424	maF-like protein
GW538_RS10995	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GW538_RS11000	COG2902	Dehydrogenase
GW538_RS11010	COG2766	serine protein kinase
GW538_RS11020	COG2719	SpoVR family
GW538_RS11030	COG1994	Peptidase M50
GW538_RS11045	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
GW538_RS11060	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GW538_RS11060	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GW538_RS11070	COG1940	carbohydrate kinase activity
GW538_RS11075	COG1011	Hydrolase
GW538_RS11085	COG4178	(ABC) transporter
GW538_RS11095	COG1194	a g-specific adenine glycosylase
GW538_RS11100	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
GW538_RS11160	COG3724	N-succinylarginine dihydrolase activity
GW538_RS11175	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GW538_RS11180	COG1607	acyl-coa hydrolase
GW538_RS11185	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GW538_RS11190	COG1561	YicC-like family, N-terminal region
GW538_RS11195	COG0194	GDP metabolic process
GW538_RS11200	COG1758	RNA polymerase activity
GW538_RS11205	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GW538_RS11220	COG3706	GGDEF domain
GW538_RS11225	COG0477	Major facilitator Superfamily
GW538_RS11230	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS11240	COG3385	transposase activity
GW538_RS11255	COG3385	transposase activity
GW538_RS11270	COG0477	Major facilitator Superfamily
GW538_RS11300	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GW538_RS11310	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GW538_RS11325	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GW538_RS11325	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GW538_RS11330	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GW538_RS11335	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GW538_RS11340	COG0488	(ABC) transporter
GW538_RS11375	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS11390	COG1555	photosystem II stabilization
GW538_RS11405	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GW538_RS11410	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GW538_RS11430	COG0402	S-adenosylhomocysteine deaminase activity
GW538_RS11465	COG3385	transposase activity
GW538_RS11490	COG0505	Belongs to the CarA family
GW538_RS11495	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GW538_RS11500	COG0540	Belongs to the ATCase OTCase family
GW538_RS11505	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GW538_RS11515	COG0542	response to heat
GW538_RS11520	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GW538_RS11560	COG2814	Major facilitator Superfamily
GW538_RS11570	COG2878	Part of a membrane complex involved in electron transport
GW538_RS11575	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GW538_RS11620	COG0670	Belongs to the BI1 family
GW538_RS11625	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
GW538_RS11640	COG2920	part of a sulfur-relay system
GW538_RS11645	COG2095	MarC family integral membrane protein
GW538_RS11680	COG0742	ribosomal rna small subunit methyltransferase
GW538_RS11735	COG2971	BadF BadG BcrA BcrD
GW538_RS11745	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GW538_RS11750	COG1959	2 iron, 2 sulfur cluster binding
GW538_RS11755	COG1017	nitric oxide dioxygenase activity
GW538_RS11755	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GW538_RS11760	COG2197	response regulator
GW538_RS11770	COG2962	Rard protein
GW538_RS11790	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GW538_RS11795	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GW538_RS11805	COG0628	permease
GW538_RS11810	COG2076	Multidrug Resistance protein
GW538_RS11830	COG1619	proteins homologs of microcin C7 resistance protein MccF
GW538_RS11845	COG3385	transposase activity
GW538_RS11855	COG2963	transposase activity
GW538_RS11885	COG3385	transposase activity
GW538_RS11915	COG2814	Major facilitator Superfamily
GW538_RS11920	COG2890	protein-(glutamine-N5) methyltransferase activity
GW538_RS11925	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GW538_RS11930	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GW538_RS11950	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GW538_RS11955	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GW538_RS11960	COG0193	aminoacyl-tRNA hydrolase activity
GW538_RS11970	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GW538_RS11975	COG2226	methyltransferase
GW538_RS11995	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS12005	COG3385	transposase activity
GW538_RS12030	COG3104	oligopeptide transport
GW538_RS12040	COG2801	Transposase and inactivated derivatives
GW538_RS12045	COG3104	oligopeptide transport
GW538_RS12055	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GW538_RS12060	COG0509	glycine decarboxylation via glycine cleavage system
GW538_RS12065	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GW538_RS12070	COG1519	Transferase
GW538_RS12075	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GW538_RS12080	COG1215	transferase activity, transferring glycosyl groups
GW538_RS12090	COG0859	PFAM glycosyl transferase family 9
GW538_RS12105	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GW538_RS12110	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GW538_RS12115	COG3161	chorismate lyase activity
GW538_RS12135	COG0247	lactate metabolic process
GW538_RS12135	COG0277	FAD linked oxidase domain protein
GW538_RS12140	COG2827	Endonuclease containing a URI domain
GW538_RS12175	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS12205	COG3385	transposase activity
GW538_RS12215	COG2801	Transposase and inactivated derivatives
GW538_RS12220	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS12240	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GW538_RS12245	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GW538_RS12250	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GW538_RS12255	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GW538_RS12260	COG1028	Short-chain dehydrogenase reductase Sdr
GW538_RS12265	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GW538_RS12270	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GW538_RS12275	COG0416	fatty acid biosynthetic process
GW538_RS12280	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GW538_RS12290	COG2823	Periplasmic or secreted lipoprotein
GW538_RS12295	COG3243	poly(R)-hydroxyalkanoic acid synthase
GW538_RS12315	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GW538_RS12350	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GW538_RS12355	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GW538_RS12360	COG1127	ABC transporter
GW538_RS12365	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GW538_RS12365	COG0517	IMP dehydrogenase activity
GW538_RS12380	COG1137	ATPase activity
GW538_RS12395	COG1660	Displays ATPase and GTPase activities
GW538_RS12410	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
GW538_RS12420	COG0784	Response regulator, receiver
GW538_RS12420	COG0835	chemotaxis
GW538_RS12510	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
GW538_RS12515	COG0512	Glutamine amidotransferase of anthranilate synthase
GW538_RS12520	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GW538_RS12535	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GW538_RS12555	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GW538_RS12565	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GW538_RS12570	COG2967	ApaG domain
GW538_RS12575	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GW538_RS12585	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS12595	COG3385	transposase activity
GW538_RS12615	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GW538_RS12620	COG4535	Mg2 and Co2 transporter CorC
GW538_RS12630	COG1702	phosphate starvation-inducible protein PhoH
GW538_RS12635	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GW538_RS12640	COG0617	tRNA 3'-terminal CCA addition
GW538_RS12645	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS12685	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GW538_RS12690	COG0724	RNA recognition motif
GW538_RS12695	COG4608	Belongs to the ABC transporter superfamily
GW538_RS12705	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GW538_RS12710	COG0601	transmembrane transport
GW538_RS12715	COG0747	negative chemotaxis
GW538_RS12720	COG0527	aspartate kinase activity
GW538_RS12725	COG0019	diaminopimelate decarboxylase activity
GW538_RS12745	COG0463	Glycosyl transferase, family 2
GW538_RS12750	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GW538_RS12755	COG2076	Multidrug Resistance protein
GW538_RS12760	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GW538_RS12765	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GW538_RS12775	COG0745	RESPONSE REGULATOR receiver
GW538_RS12835	COG3385	transposase activity
GW538_RS12845	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GW538_RS12865	COG0328	RNA-DNA hybrid ribonuclease activity
GW538_RS12890	COG3385	transposase activity
GW538_RS12905	COG4166	transmembrane transport
GW538_RS12940	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GW538_RS12945	COG0813	purine-nucleoside phosphorylase activity
GW538_RS12955	COG0167	dihydroorotate dehydrogenase activity
GW538_RS12965	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GW538_RS12965	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GW538_RS13030	COG0242	peptide deformylase activity
GW538_RS13040	COG0784	Response regulator, receiver
GW538_RS13040	COG0835	chemotaxis
GW538_RS13050	COG0425	Belongs to the sulfur carrier protein TusA family
GW538_RS13245	COG2805	Type II/IV secretion system protein
GW538_RS13290	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GW538_RS13310	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS13320	COG3385	transposase activity
GW538_RS13330	COG0071	Belongs to the small heat shock protein (HSP20) family
GW538_RS13335	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GW538_RS13350	COG3385	transposase activity
GW538_RS13360	COG1131	(ABC) transporter
GW538_RS13370	COG4206	TonB-dependent receptor
GW538_RS13390	COG1280	lysine exporter protein (LysE YggA)
GW538_RS13395	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GW538_RS13405	COG3385	transposase activity
GW538_RS13425	COG3385	transposase activity
GW538_RS13435	COG3012	SEC-C Motif Domain Protein
GW538_RS13445	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
GW538_RS13450	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
GW538_RS13460	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
GW538_RS13470	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
GW538_RS13490	COG0306	phosphate transporter
GW538_RS13495	COG1392	Phosphate transport regulator
GW538_RS13530	COG3385	transposase activity
GW538_RS13555	COG0833	amino acid
GW538_RS13560	COG0114	fumarate hydratase activity
GW538_RS13585	COG3385	transposase activity
GW538_RS13595	COG3385	transposase activity
GW538_RS13625	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS13650	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS13655	COG0724	RNA recognition motif
GW538_RS13660	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS13760	COG2805	Type II/IV secretion system protein
GW538_RS13815	COG0586	Pfam SNARE associated Golgi protein
GW538_RS13820	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GW538_RS13835	COG3385	transposase activity
GW538_RS13845	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS13850	COG1063	alcohol dehydrogenase
GW538_RS13855	COG0156	8-amino-7-oxononanoate synthase activity
GW538_RS13890	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GW538_RS13905	COG0596	Alpha beta hydrolase
GW538_RS13915	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GW538_RS13920	COG1040	competence protein
GW538_RS13945	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
GW538_RS13945	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GW538_RS13950	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GW538_RS13990	COG0561	phosphatase activity
GW538_RS14000	COG3385	transposase activity
GW538_RS14025	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GW538_RS14035	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GW538_RS14055	COG0776	regulation of translation
GW538_RS14060	COG0745	RESPONSE REGULATOR receiver
GW538_RS14075	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GW538_RS14080	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GW538_RS14085	COG3079	Belongs to the UPF0149 family
GW538_RS14105	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GW538_RS14125	COG0494	nUDIX hydrolase
GW538_RS14130	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GW538_RS14155	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS14180	COG3385	transposase activity
GW538_RS14190	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GW538_RS14195	COG0321	lipoyl(octanoyl) transferase activity
GW538_RS14205	COG1686	Belongs to the peptidase S11 family
GW538_RS14215	COG2951	lytic endotransglycosylase activity
GW538_RS14220	COG0772	Belongs to the SEDS family
GW538_RS14225	COG0768	penicillin binding
GW538_RS14230	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GW538_RS14240	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GW538_RS14245	COG1466	dna polymerase III delta subunit
GW538_RS14255	COG0495	leucyl-tRNA aminoacylation
GW538_RS14280	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GW538_RS14300	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GW538_RS14315	COG0018	arginyl-trna synthetase
GW538_RS14320	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GW538_RS14340	COG0180	Tryptophanyl-tRNA synthetase
GW538_RS14345	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GW538_RS14350	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GW538_RS14355	COG1253	flavin adenine dinucleotide binding
GW538_RS14375	COG2801	Transposase and inactivated derivatives
GW538_RS14385	COG3385	transposase activity
GW538_RS14410	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GW538_RS14415	COG2814	Major facilitator Superfamily
GW538_RS14420	COG0203	ribosomal protein L17
GW538_RS14425	COG0202	RNA polymerase activity
GW538_RS14430	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GW538_RS14435	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GW538_RS14440	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GW538_RS14455	COG0200	Binds to the 23S rRNA
GW538_RS14465	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GW538_RS14470	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GW538_RS14475	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GW538_RS14480	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GW538_RS14485	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GW538_RS14495	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GW538_RS14505	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GW538_RS14510	COG0255	Belongs to the universal ribosomal protein uL29 family
GW538_RS14515	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GW538_RS14520	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GW538_RS14525	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GW538_RS14530	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GW538_RS14535	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GW538_RS14540	COG0089	rRNA binding
GW538_RS14550	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GW538_RS14555	COG0051	transcription antitermination factor activity, RNA binding
GW538_RS14560	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GW538_RS14565	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GW538_RS14570	COG0049	tRNA binding
GW538_RS14575	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GW538_RS14585	COG0085	RNA polymerase activity
GW538_RS14590	COG0222	ribosome binding
GW538_RS14595	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GW538_RS14600	COG0081	regulation of translation
GW538_RS14605	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GW538_RS14615	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GW538_RS14650	COG1459	type II secretion system
GW538_RS14670	COG0237	dephospho-CoA kinase activity
GW538_RS14675	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
GW538_RS14680	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
GW538_RS14690	COG3130	regulation of translation
GW538_RS14695	COG0477	Major facilitator Superfamily
GW538_RS14705	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GW538_RS14710	COG0484	heat shock protein binding
GW538_RS14715	COG0443	Heat shock 70 kDa protein
GW538_RS14720	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GW538_RS14725	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GW538_RS14730	COG0497	DNA recombination
GW538_RS14740	COG0735	belongs to the Fur family
GW538_RS14760	COG2867	negative regulation of translational initiation
GW538_RS14765	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GW538_RS14770	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GW538_RS14780	COG2066	Belongs to the glutaminase family
GW538_RS14790	COG1490	D-aminoacyl-tRNA deacylase activity
GW538_RS14805	COG2853	Lipoprotein
GW538_RS14815	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS14835	COG1028	Short-chain dehydrogenase reductase Sdr
GW538_RS14840	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS14845	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GW538_RS14875	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GW538_RS14880	COG0617	tRNA 3'-terminal CCA addition
GW538_RS14885	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GW538_RS14895	COG1028	Short-chain dehydrogenase reductase Sdr
GW538_RS14915	COG3243	poly(R)-hydroxyalkanoic acid synthase
GW538_RS14925	COG1185	polyribonucleotide nucleotidyltransferase activity
GW538_RS14930	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GW538_RS14935	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GW538_RS14940	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GW538_RS14945	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GW538_RS14950	COG0195	Participates in both transcription termination and antitermination
GW538_RS14950	COG2251	uridine kinase activity
GW538_RS14965	COG1007	ATP synthesis coupled electron transport
GW538_RS14980	COG0713	ATP synthesis coupled electron transport
GW538_RS14985	COG0839	Belongs to the complex I subunit 6 family
GW538_RS14990	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GW538_RS14995	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GW538_RS15000	COG1034	ATP synthesis coupled electron transport
GW538_RS15000	COG1034	ATP synthesis coupled electron transport
GW538_RS15005	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
GW538_RS15010	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
GW538_RS15015	COG0649	NAD binding
GW538_RS15025	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GW538_RS15030	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GW538_RS15040	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GW538_RS15045	COG0149	triose-phosphate isomerase activity
GW538_RS15065	COG1435	thymidine kinase activity
GW538_RS15080	COG2363	Small membrane protein
GW538_RS15095	COG0494	nUDIX hydrolase
GW538_RS15115	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GW538_RS15125	COG0254	rRNA binding
GW538_RS15150	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS15165	COG3186	Phenylalanine-4-hydroxylase
GW538_RS15180	COG0625	glutathione transferase activity
GW538_RS15185	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GW538_RS15195	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GW538_RS15200	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GW538_RS15200	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GW538_RS15205	COG0708	Exodeoxyribonuclease III
GW538_RS15210	COG0330	HflC and HflK could
GW538_RS15215	COG1585	Membrane protein implicated in regulation of membrane protease activity
GW538_RS15240	COG3385	transposase activity
GW538_RS15260	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GW538_RS15265	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GW538_RS15270	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GW538_RS15335	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
GW538_RS15390	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GW538_RS15410	COG0248	Ppx GppA phosphatase
GW538_RS15425	COG0531	amino acid
GW538_RS15430	COG0174	glutamine synthetase
GW538_RS15435	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GW538_RS15440	COG0668	transmembrane transport
GW538_RS15475	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GW538_RS15485	COG2988	succinylglutamate desuccinylase activity
GW538_RS15510	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS15520	COG2271	Major facilitator Superfamily
GW538_RS15530	COG2814	Major facilitator Superfamily
GW538_RS15535	COG0583	DNA-binding transcription factor activity
GW538_RS15545	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GW538_RS15550	COG4796	Type ii and iii secretion system protein
GW538_RS15600	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GW538_RS15605	COG0017	Asparaginyl-tRNA synthetase
GW538_RS15610	COG4962	Type ii secretion system protein e
GW538_RS15635	COG3504	Conjugal transfer protein
GW538_RS15645	COG3451	type IV secretory pathway VirB4
GW538_RS15695	COG0606	chelatase, subunit chli
GW538_RS15705	COG0347	Belongs to the P(II) protein family
GW538_RS15710	COG1166	arginine decarboxylase activity
GW538_RS15720	COG0463	Glycosyl transferase, family 2
GW538_RS15725	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
GW538_RS15735	COG0133	tryptophan synthase activity
GW538_RS15750	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GW538_RS15755	COG0512	Glutamine amidotransferase of anthranilate synthase
GW538_RS15755	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GW538_RS15790	COG0450	alkyl hydroperoxide reductase
GW538_RS15815	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS15825	COG3385	transposase activity
GW538_RS15830	COG3385	transposase activity
GW538_RS15870	COG0752	glycyl-tRNA synthetase alpha subunit
GW538_RS15880	COG1607	acyl-coa hydrolase
GW538_RS15885	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GW538_RS15910	COG2828	Protein conserved in bacteria
GW538_RS15915	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GW538_RS15920	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GW538_RS15925	COG0569	domain protein
GW538_RS15930	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GW538_RS15935	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GW538_RS15940	COG0242	peptide deformylase activity
GW538_RS15945	COG0758	DNA mediated transformation
GW538_RS15950	COG2922	Belongs to the Smg family
GW538_RS15960	COG0009	L-threonylcarbamoyladenylate synthase
GW538_RS15965	COG0408	coproporphyrinogen oxidase activity
GW538_RS15975	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS15990	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS16010	COG3385	transposase activity
GW538_RS16035	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GW538_RS16045	COG0793	Belongs to the peptidase S41A family
GW538_RS16055	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GW538_RS16065	COG3385	transposase activity
GW538_RS16090	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GW538_RS16090	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GW538_RS16095	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GW538_RS16105	COG3227	Zinc metalloprotease (Elastase)
GW538_RS16120	COG0456	acetyltransferase
GW538_RS16120	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
GW538_RS16160	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
GW538_RS16165	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GW538_RS16175	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GW538_RS16180	COG1181	Belongs to the D-alanine--D-alanine ligase family
GW538_RS16185	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GW538_RS16190	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GW538_RS16195	COG0772	Belongs to the SEDS family
GW538_RS16200	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GW538_RS16205	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GW538_RS16210	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GW538_RS16215	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GW538_RS16230	COG0275	rRNA processing
GW538_RS16235	COG2983	Belongs to the UPF0260 family
GW538_RS16250	COG0187	DNA topoisomerase II activity
GW538_RS16260	COG0592	DNA-directed DNA polymerase activity
GW538_RS16265	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GW538_RS16300	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GW538_RS16305	COG1064	alcohol dehydrogenase
GW538_RS16330	COG4456	Virulence-associated protein
GW538_RS16360	COG1802	Transcriptional regulator
GW538_RS16360	COG4626	Terminase
GW538_RS16365	COG4626	Terminase
GW538_RS16365	COG1802	Transcriptional regulator
GW538_RS16410	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS16705	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GW538_RS16715	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS16760	COG1192	Involved in chromosome partitioning
GW538_RS16770	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS16780	COG2963	transposase activity
GW538_RS16845	COG3385	transposase activity
GW538_RS16865	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS16905	COG4946	Tricorn protease homolog
GW538_RS16905	COG0823	Involved in the tonB-independent uptake of proteins
GW538_RS16905	COG1506	peptidase
GW538_RS17025	COG0730	response to heat
GW538_RS17030	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS17075	COG3385	transposase activity
GW538_RS17090	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GW538_RS17120	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GW538_RS17180	COG0842	Transport permease protein
GW538_RS17185	COG3177	Filamentation induced by cAMP protein fic
GW538_RS17235	COG2963	transposase activity
GW538_RS17315	COG4115	mRNA cleavage
GW538_RS17370	COG3023	N-Acetylmuramoyl-L-alanine amidase
GW538_RS17425	COG3850	Histidine kinase
GW538_RS17425	COG5002	protein histidine kinase activity
GW538_RS17435	COG1196	nuclear chromosome segregation
GW538_RS17445	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GW538_RS17450	COG1064	alcohol dehydrogenase
GW538_RS17475	COG4456	Virulence-associated protein
GW538_RS17480	COG1487	ribonuclease activity
GW538_RS17515	COG1802	Transcriptional regulator
GW538_RS17515	COG4626	Terminase
GW538_RS17595	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GW538_RS17650	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS17675	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS17680	COG0724	RNA recognition motif
GW538_RS17685	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS17695	COG0477	Major facilitator Superfamily
GW538_RS17715	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS17725	COG3657	addiction module killer protein
GW538_RS17775	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS17795	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS17815	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS17915	COG1192	Involved in chromosome partitioning
GW538_RS17940	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS17965	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS17970	COG0724	RNA recognition motif
GW538_RS17975	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS17985	COG0477	Major facilitator Superfamily
GW538_RS18045	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS18060	COG4974	Belongs to the 'phage' integrase family
GW538_RS18070	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS18085	COG1475	DNA binding
GW538_RS18090	COG1192	Involved in chromosome partitioning
GW538_RS18120	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS18140	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS18160	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS18205	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS18220	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS18245	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS18270	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS18285	COG4974	Belongs to the 'phage' integrase family
GW538_RS18295	COG2826	transposase and inactivated derivatives, IS30 family
GW538_RS18310	COG1475	DNA binding
GW538_RS18315	COG1192	Involved in chromosome partitioning
GW538_RS18375	COG2826	transposase and inactivated derivatives, IS30 family