locus-tag	class	description
PBC10988_RS00050	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
PBC10988_RS00055	COG0133	tryptophan synthase activity
PBC10988_RS00060	COG0159	tryptophan synthase activity
PBC10988_RS00105	COG2363	Small membrane protein
PBC10988_RS00110	COG1595	DNA-templated transcription, initiation
PBC10988_RS00140	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
PBC10988_RS00145	COG0204	Acyl-transferase
PBC10988_RS00145	COG0318	PFAM AMP-dependent synthetase and ligase
PBC10988_RS00195	COG0406	alpha-ribazole phosphatase activity
PBC10988_RS00205	COG0799	negative regulation of ribosome biogenesis
PBC10988_RS00215	COG1136	(ABC) transporter
PBC10988_RS00215	COG0577	efflux transmembrane transporter activity
PBC10988_RS00245	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
PBC10988_RS00255	COG0515	serine threonine protein kinase
PBC10988_RS00255	COG2815	serine threonine protein kinase
PBC10988_RS00265	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PBC10988_RS00275	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
PBC10988_RS00285	COG2226	methyltransferase
PBC10988_RS00290	COG3386	PFAM SMP-30 Gluconolaconase
PBC10988_RS00310	COG1338	Plays a role in the flagellum-specific transport system
PBC10988_RS00315	COG1987	bacterial-type flagellum assembly
PBC10988_RS00330	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PBC10988_RS00345	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
PBC10988_RS00350	COG3119	arylsulfatase activity
PBC10988_RS00365	COG2721	sulfolactate sulfo-lyase activity
PBC10988_RS00375	COG3386	PFAM SMP-30 Gluconolaconase
PBC10988_RS00380	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
PBC10988_RS00385	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
PBC10988_RS00400	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
PBC10988_RS00420	COG2046	Belongs to the sulfate adenylyltransferase family
PBC10988_RS00435	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
PBC10988_RS00440	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
PBC10988_RS00470	COG3119	arylsulfatase activity
PBC10988_RS00480	COG2815	serine threonine protein kinase
PBC10988_RS00480	COG0515	serine threonine protein kinase
PBC10988_RS00535	COG3842	ATPase activity
PBC10988_RS00540	COG1694	Mazg nucleotide pyrophosphohydrolase
PBC10988_RS00550	COG0277	FAD linked oxidase domain protein
PBC10988_RS00555	COG0277	FAD linked oxidase domain protein
PBC10988_RS00560	COG0247	lactate metabolic process
PBC10988_RS00565	COG0039	L-malate dehydrogenase activity
PBC10988_RS00570	COG0235	Class ii aldolase
PBC10988_RS00600	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
PBC10988_RS00605	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
PBC10988_RS00610	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
PBC10988_RS00615	COG4869	propanediol catabolic process
PBC10988_RS00630	COG0812	UDP-N-acetylmuramate dehydrogenase activity
PBC10988_RS00635	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
PBC10988_RS00655	COG0189	ligase activity
PBC10988_RS00665	COG1657	PFAM Prenyltransferase squalene oxidase
PBC10988_RS00670	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PBC10988_RS00675	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
PBC10988_RS00690	COG0318	PFAM AMP-dependent synthetase and ligase
PBC10988_RS00700	COG3118	belongs to the thioredoxin family
PBC10988_RS00725	COG0719	Fe-S assembly protein
PBC10988_RS00730	COG0719	Fe-S assembly protein
PBC10988_RS00735	COG0396	ATPase activity
PBC10988_RS00740	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PBC10988_RS00750	COG1115	amino acid carrier protein
PBC10988_RS00770	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
PBC10988_RS00785	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
PBC10988_RS00790	COG0557	exoribonuclease II activity
PBC10988_RS00795	COG3481	metal-dependent phosphohydrolase, HD sub domain
PBC10988_RS00825	COG0556	nucleotide-excision repair
PBC10988_RS00830	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
PBC10988_RS00835	COG2088	sporulation resulting in formation of a cellular spore
PBC10988_RS00840	COG0047	phosphoribosylformylglycinamidine synthase activity
PBC10988_RS00845	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
PBC10988_RS00850	COG0287	Prephenate dehydrogenase
PBC10988_RS00855	COG1459	type II secretion system
PBC10988_RS00895	COG0009	L-threonylcarbamoyladenylate synthase
PBC10988_RS00930	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PBC10988_RS00945	COG1196	nuclear chromosome segregation
PBC10988_RS00970	COG3119	arylsulfatase activity
PBC10988_RS00985	COG3119	arylsulfatase activity
PBC10988_RS01035	COG1309	transcriptional regulator
PBC10988_RS01045	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PBC10988_RS01060	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PBC10988_RS01070	COG3485	protocatechuate 3,4-dioxygenase
PBC10988_RS01075	COG3119	arylsulfatase activity
PBC10988_RS01130	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
PBC10988_RS01135	COG0518	GMP synthase (glutamine-hydrolyzing) activity
PBC10988_RS01135	COG0519	Catalyzes the synthesis of GMP from XMP
PBC10988_RS01145	COG0742	ribosomal rna small subunit methyltransferase
PBC10988_RS01160	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
PBC10988_RS01170	COG0673	inositol 2-dehydrogenase activity
PBC10988_RS01220	COG1477	protein flavinylation
PBC10988_RS01230	COG1160	GTP binding
PBC10988_RS01245	COG1331	Highly conserved protein containing a thioredoxin domain
PBC10988_RS01250	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
PBC10988_RS01260	COG2154	pterin-4-alpha-carbinolamine dehydratase
PBC10988_RS01265	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
PBC10988_RS01280	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
PBC10988_RS01330	COG3209	COG3209 Rhs family protein
PBC10988_RS01360	COG3209	COG3209 Rhs family protein
PBC10988_RS01410	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
PBC10988_RS01455	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
PBC10988_RS01665	COG1518	maintenance of DNA repeat elements
PBC10988_RS01705	COG1215	transferase activity, transferring glycosyl groups
PBC10988_RS01755	COG1674	ftsk spoiiie
PBC10988_RS01785	COG2207	Transcriptional regulator
PBC10988_RS01990	COG2255	four-way junction helicase activity
PBC10988_RS02190	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
PBC10988_RS02245	COG2801	Transposase and inactivated derivatives
PBC10988_RS02250	COG2963	transposase activity
PBC10988_RS02460	COG5285	phytanoyl-CoA dioxygenase
PBC10988_RS02465	COG1917	Cupin 2, conserved barrel domain protein
PBC10988_RS02470	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
PBC10988_RS02515	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PBC10988_RS02535	COG1566	PFAM secretion protein HlyD family protein
PBC10988_RS02575	COG5002	protein histidine kinase activity
PBC10988_RS02580	COG0028	Belongs to the TPP enzyme family
PBC10988_RS02675	COG5444	nuclease activity
PBC10988_RS02715	COG0022	dehydrogenase e1 component
PBC10988_RS02740	COG1335	isochorismatase
PBC10988_RS02745	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PBC10988_RS02745	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
PBC10988_RS02755	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
PBC10988_RS02760	COG0066	3-isopropylmalate dehydratase activity
PBC10988_RS02770	COG0516	GMP reductase activity
PBC10988_RS02770	COG0517	IMP dehydrogenase activity
PBC10988_RS02780	COG0463	Glycosyl transferase, family 2
PBC10988_RS02795	COG1132	(ABC) transporter
PBC10988_RS02800	COG2239	Acts as a magnesium transporter
PBC10988_RS02805	COG0456	acetyltransferase
PBC10988_RS02830	COG3119	arylsulfatase activity
PBC10988_RS02835	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
PBC10988_RS02845	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
PBC10988_RS02855	COG3408	Glycogen debranching enzyme
PBC10988_RS02855	COG3119	arylsulfatase activity
PBC10988_RS02860	COG2326	polyphosphate kinase activity
PBC10988_RS02865	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
PBC10988_RS02890	COG0515	serine threonine protein kinase
PBC10988_RS02890	COG0457	Tetratricopeptide repeat
PBC10988_RS02915	COG0463	Glycosyl transferase, family 2
PBC10988_RS02920	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
PBC10988_RS02935	COG2815	serine threonine protein kinase
PBC10988_RS02935	COG0515	serine threonine protein kinase
PBC10988_RS02975	COG2755	lipolytic protein G-D-S-L family
PBC10988_RS02975	COG0657	acetylesterase activity
PBC10988_RS02995	COG0667	Aldo Keto reductase
PBC10988_RS03015	COG1477	protein flavinylation
PBC10988_RS03025	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
PBC10988_RS03035	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PBC10988_RS03055	COG3119	arylsulfatase activity
PBC10988_RS03065	COG3119	arylsulfatase activity
PBC10988_RS03075	COG0673	inositol 2-dehydrogenase activity
PBC10988_RS03080	COG3119	arylsulfatase activity
PBC10988_RS03095	COG2304	oxidoreductase activity
PBC10988_RS03115	COG0714	Associated with various cellular activities
PBC10988_RS03120	COG3119	arylsulfatase activity
PBC10988_RS03125	COG3119	arylsulfatase activity
PBC10988_RS03130	COG3119	arylsulfatase activity
PBC10988_RS03130	COG3408	Glycogen debranching enzyme
PBC10988_RS03140	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
PBC10988_RS03150	COG1595	DNA-templated transcription, initiation
PBC10988_RS03220	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
PBC10988_RS03220	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
PBC10988_RS03225	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
PBC10988_RS03230	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
PBC10988_RS03240	COG1192	Involved in chromosome partitioning
PBC10988_RS03245	COG1475	DNA binding
PBC10988_RS03255	COG4974	Belongs to the 'phage' integrase family
PBC10988_RS03275	COG0017	Asparaginyl-tRNA synthetase
PBC10988_RS03305	COG4974	Belongs to the 'phage' integrase family
PBC10988_RS03330	COG1595	DNA-templated transcription, initiation
PBC10988_RS03340	COG1733	regulation of RNA biosynthetic process
PBC10988_RS03345	COG1335	isochorismatase
PBC10988_RS03405	COG1431	PFAM Stem cell self-renewal protein Piwi
PBC10988_RS03445	COG2815	serine threonine protein kinase
PBC10988_RS03445	COG0515	serine threonine protein kinase
PBC10988_RS03460	COG1090	epimerase
PBC10988_RS03480	COG3106	COG3106 Predicted ATPase
PBC10988_RS03485	COG3768	UPF0283 membrane protein
PBC10988_RS03550	COG3119	arylsulfatase activity
PBC10988_RS03590	COG0811	peptide transport
PBC10988_RS03595	COG0848	biopolymer transport protein
PBC10988_RS03600	COG1562	ergosterol biosynthetic process
PBC10988_RS03605	COG1562	ergosterol biosynthetic process
PBC10988_RS03610	COG1233	COG1233 Phytoene dehydrogenase and related
PBC10988_RS03615	COG0673	inositol 2-dehydrogenase activity
PBC10988_RS03620	COG0793	Belongs to the peptidase S41A family
PBC10988_RS03630	COG3119	arylsulfatase activity
PBC10988_RS03645	COG3119	arylsulfatase activity
PBC10988_RS03660	COG3119	arylsulfatase activity
PBC10988_RS03745	COG3795	YCII-related domain
PBC10988_RS03755	COG4941	Belongs to the sigma-70 factor family
PBC10988_RS03770	COG3119	arylsulfatase activity
PBC10988_RS03775	COG3119	arylsulfatase activity
PBC10988_RS03780	COG0657	acetylesterase activity
PBC10988_RS03790	COG3119	arylsulfatase activity
PBC10988_RS03795	COG2124	cytochrome p450
PBC10988_RS03830	COG3119	arylsulfatase activity
PBC10988_RS03840	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
PBC10988_RS03845	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
PBC10988_RS03855	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
PBC10988_RS03860	COG0358	DNA primase activity
PBC10988_RS03865	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
PBC10988_RS03880	COG3119	arylsulfatase activity
PBC10988_RS03885	COG3119	arylsulfatase activity
PBC10988_RS03890	COG3119	arylsulfatase activity
PBC10988_RS03925	COG0602	queuosine metabolic process
PBC10988_RS03930	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
PBC10988_RS03935	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
PBC10988_RS03940	COG2183	response to ionizing radiation
PBC10988_RS03955	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
PBC10988_RS03970	COG2205	protein histidine kinase activity
PBC10988_RS03970	COG4999	Histidine kinase
PBC10988_RS03970	COG3437	response regulator, receiver
PBC10988_RS03970	COG3850	Histidine kinase
PBC10988_RS03980	COG4589	Belongs to the CDS family
PBC10988_RS03985	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
PBC10988_RS03990	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
PBC10988_RS04000	COG2373	Large extracellular alpha-helical protein
PBC10988_RS04040	COG3852	Histidine kinase
PBC10988_RS04045	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
PBC10988_RS04060	COG0402	S-adenosylhomocysteine deaminase activity
PBC10988_RS04070	COG0443	Heat shock 70 kDa protein
PBC10988_RS04075	COG0443	Heat shock 70 kDa protein
PBC10988_RS04080	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
PBC10988_RS04095	COG0489	protein tyrosine kinase activity
PBC10988_RS04105	COG1136	(ABC) transporter
PBC10988_RS04105	COG0577	efflux transmembrane transporter activity
PBC10988_RS04110	COG0577	efflux transmembrane transporter activity
PBC10988_RS04110	COG1136	(ABC) transporter
PBC10988_RS04125	COG4122	O-methyltransferase activity
PBC10988_RS04140	COG0833	amino acid
PBC10988_RS04185	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
PBC10988_RS04185	COG2207	Transcriptional regulator
PBC10988_RS04190	COG4251	negative regulation of phosphorylation
PBC10988_RS04200	COG2205	protein histidine kinase activity
PBC10988_RS04200	COG2202	Pas domain
PBC10988_RS04235	COG2165	general secretion pathway protein
PBC10988_RS04265	COG1459	type II secretion system
PBC10988_RS04290	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PBC10988_RS04295	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
PBC10988_RS04310	COG0815	Transfers the fatty acyl group on membrane lipoproteins
PBC10988_RS04325	COG0477	Major facilitator Superfamily
PBC10988_RS04335	COG0515	serine threonine protein kinase
PBC10988_RS04335	COG2815	serine threonine protein kinase
PBC10988_RS04340	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
PBC10988_RS04345	COG0235	Class ii aldolase
PBC10988_RS04350	COG1166	arginine decarboxylase activity
PBC10988_RS04360	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
PBC10988_RS04365	COG0730	response to heat
PBC10988_RS04385	COG0539	negative regulation of cytoplasmic translation
PBC10988_RS04395	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
PBC10988_RS04405	COG0438	transferase activity, transferring glycosyl groups
PBC10988_RS04410	COG3119	arylsulfatase activity
PBC10988_RS04430	COG0346	lactoylglutathione lyase activity
PBC10988_RS04435	COG0640	Transcriptional regulator
PBC10988_RS04450	COG0367	asparagine synthase
PBC10988_RS04455	COG1473	amidohydrolase
PBC10988_RS04460	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
PBC10988_RS04510	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
PBC10988_RS04535	COG1774	PSP1 C-terminal conserved region
PBC10988_RS04545	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
PBC10988_RS04565	COG0540	Belongs to the ATCase OTCase family
PBC10988_RS04570	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
PBC10988_RS04595	COG2234	aminopeptidase activity
PBC10988_RS04605	COG3119	arylsulfatase activity
PBC10988_RS04615	COG0583	DNA-binding transcription factor activity
PBC10988_RS04620	COG0067	glutamate synthase
PBC10988_RS04620	COG0069	glutamate synthase activity
PBC10988_RS04620	COG0070	glutamate synthase
PBC10988_RS04625	COG0493	'glutamate synthase
PBC10988_RS04655	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
PBC10988_RS04660	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
PBC10988_RS04665	COG0581	inorganic phosphate transmembrane transporter activity
PBC10988_RS04670	COG0573	inorganic phosphate transmembrane transporter activity
PBC10988_RS04675	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
PBC10988_RS04690	COG4864	UPF0365 protein
PBC10988_RS04705	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
PBC10988_RS04710	COG4555	ABC transporter
PBC10988_RS04720	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
PBC10988_RS04725	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
PBC10988_RS04730	COG1028	Short-chain dehydrogenase reductase Sdr
PBC10988_RS04740	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
PBC10988_RS04760	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
PBC10988_RS04765	COG0802	atpase or kinase
PBC10988_RS04775	COG2815	serine threonine protein kinase
PBC10988_RS04775	COG0515	serine threonine protein kinase
PBC10988_RS04780	COG0515	serine threonine protein kinase
PBC10988_RS04780	COG2815	serine threonine protein kinase
PBC10988_RS04790	COG4284	Utp--glucose-1-phosphate uridylyltransferase
PBC10988_RS04800	COG0463	Glycosyl transferase, family 2
PBC10988_RS04810	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PBC10988_RS04815	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PBC10988_RS04820	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
PBC10988_RS04865	COG4191	Histidine kinase
PBC10988_RS04875	COG0542	response to heat
PBC10988_RS04890	COG3852	Histidine kinase
PBC10988_RS04895	COG1757	Na H antiporter
PBC10988_RS04905	COG1131	(ABC) transporter
PBC10988_RS04940	COG1229	Formylmethanofuran dehydrogenase subunit A
PBC10988_RS04985	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
PBC10988_RS04990	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
PBC10988_RS05005	COG1570	exodeoxyribonuclease VII activity
PBC10988_RS05015	COG0668	transmembrane transport
PBC10988_RS05020	COG2197	response regulator
PBC10988_RS05030	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
PBC10988_RS05035	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
PBC10988_RS05045	COG0174	glutamine synthetase
PBC10988_RS05075	COG0267	Belongs to the bacterial ribosomal protein bL33 family
PBC10988_RS05080	COG1515	deoxyribonuclease V activity
PBC10988_RS05095	COG0673	inositol 2-dehydrogenase activity
PBC10988_RS05110	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
PBC10988_RS05125	COG2084	Dehydrogenase
PBC10988_RS05130	COG0488	(ABC) transporter
PBC10988_RS05135	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
PBC10988_RS05155	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
PBC10988_RS05165	COG3119	arylsulfatase activity
PBC10988_RS05170	COG3119	arylsulfatase activity
PBC10988_RS05195	COG0537	adenosine 5'-monophosphoramidase activity
PBC10988_RS05220	COG0583	DNA-binding transcription factor activity
PBC10988_RS05255	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PBC10988_RS05260	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PBC10988_RS05315	COG3119	arylsulfatase activity
PBC10988_RS05320	COG3119	arylsulfatase activity
PBC10988_RS05325	COG3119	arylsulfatase activity
PBC10988_RS05365	COG1136	(ABC) transporter
PBC10988_RS05370	COG1595	DNA-templated transcription, initiation
PBC10988_RS05380	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
PBC10988_RS05385	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
PBC10988_RS05390	COG0076	glutamate decarboxylase activity
PBC10988_RS05405	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
PBC10988_RS05425	COG2814	Major facilitator Superfamily
PBC10988_RS05435	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
PBC10988_RS05440	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
PBC10988_RS05465	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
PBC10988_RS05470	COG0793	Belongs to the peptidase S41A family
PBC10988_RS05525	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
PBC10988_RS05540	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
PBC10988_RS05565	COG1234	tRNA 3'-trailer cleavage
PBC10988_RS05570	COG1846	Transcriptional regulator
PBC10988_RS05585	COG0318	PFAM AMP-dependent synthetase and ligase
PBC10988_RS05590	COG3875	lactate racemase activity
PBC10988_RS05610	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
PBC10988_RS05615	COG1215	transferase activity, transferring glycosyl groups
PBC10988_RS05645	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
PBC10988_RS05650	COG2009	succinate dehydrogenase
PBC10988_RS05655	COG1053	succinate dehydrogenase
PBC10988_RS05660	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
PBC10988_RS05690	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
PBC10988_RS05710	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
PBC10988_RS05730	COG0784	Response regulator, receiver
PBC10988_RS05735	COG4251	negative regulation of phosphorylation
PBC10988_RS05740	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PBC10988_RS05745	COG0612	Peptidase, M16
PBC10988_RS05750	COG0612	Peptidase, M16
PBC10988_RS05770	COG2133	pyrroloquinoline quinone binding
PBC10988_RS05775	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
PBC10988_RS05780	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
PBC10988_RS05790	COG0247	lactate metabolic process
PBC10988_RS05790	COG0277	FAD linked oxidase domain protein
PBC10988_RS05800	COG0314	molybdopterin synthase activity
PBC10988_RS05805	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
PBC10988_RS05810	COG0640	Transcriptional regulator
PBC10988_RS05820	COG5285	phytanoyl-CoA dioxygenase
PBC10988_RS05835	COG1850	ribulose-bisphosphate carboxylase activity
PBC10988_RS05840	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
PBC10988_RS05845	COG0460	homoserine dehydrogenase
PBC10988_RS05850	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
PBC10988_RS05875	COG1129	ABC transporter
PBC10988_RS05880	COG1172	Belongs to the binding-protein-dependent transport system permease family
PBC10988_RS05885	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
PBC10988_RS05890	COG0423	glycine-tRNA ligase activity
PBC10988_RS05895	COG2045	Belongs to the ComB family
PBC10988_RS05900	COG0564	pseudouridine synthase activity
PBC10988_RS05905	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
PBC10988_RS05935	COG0511	ligase activity, forming carbon-carbon bonds
PBC10988_RS05940	COG0439	Biotin carboxylase
PBC10988_RS05950	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
PBC10988_RS05965	COG4796	Type ii and iii secretion system protein
PBC10988_RS05975	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
PBC10988_RS05980	COG1030	water channel activity
PBC10988_RS05985	COG1234	tRNA 3'-trailer cleavage
PBC10988_RS05990	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
PBC10988_RS06050	COG2382	esterase
PBC10988_RS06055	COG0657	acetylesterase activity
PBC10988_RS06100	COG4651	solute:proton antiporter activity
PBC10988_RS06100	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
PBC10988_RS06130	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
PBC10988_RS06180	COG3869	Catalyzes the specific phosphorylation of arginine residues in
PBC10988_RS06185	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
PBC10988_RS06210	COG0268	Binds directly to 16S ribosomal RNA
PBC10988_RS06215	COG0543	2 iron, 2 sulfur cluster binding
PBC10988_RS06220	COG1187	pseudouridine synthase activity
PBC10988_RS06230	COG2096	Adenosyltransferase
PBC10988_RS06240	COG0189	ligase activity
PBC10988_RS06240	COG4067	protein conserved in archaea
PBC10988_RS06245	COG0189	ligase activity
PBC10988_RS06250	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
PBC10988_RS06255	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
PBC10988_RS06260	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
PBC10988_RS06285	COG1716	ATPase activity
PBC10988_RS06295	COG1045	serine acetyltransferase
PBC10988_RS06300	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
PBC10988_RS06305	COG0594	ribonuclease P activity
PBC10988_RS06320	COG1028	Short-chain dehydrogenase reductase Sdr
PBC10988_RS06480	COG3119	arylsulfatase activity
PBC10988_RS06485	COG3119	arylsulfatase activity
PBC10988_RS06485	COG3408	Glycogen debranching enzyme
PBC10988_RS06490	COG3119	arylsulfatase activity
PBC10988_RS06495	COG3119	arylsulfatase activity
PBC10988_RS06545	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PBC10988_RS06565	COG0205	6-phosphofructokinase activity
PBC10988_RS06585	COG2378	regulation of single-species biofilm formation
PBC10988_RS06595	COG0746	molybdenum cofactor guanylyltransferase activity
PBC10988_RS06630	COG1609	Transcriptional regulator
PBC10988_RS06630	COG2207	Transcriptional regulator
PBC10988_RS06635	COG1063	alcohol dehydrogenase
PBC10988_RS06645	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PBC10988_RS06660	COG3119	arylsulfatase activity
PBC10988_RS06660	COG3119	arylsulfatase activity
PBC10988_RS06755	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PBC10988_RS06780	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
PBC10988_RS06785	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
PBC10988_RS06790	COG1758	RNA polymerase activity
PBC10988_RS06795	COG0194	GDP metabolic process
PBC10988_RS06800	COG1561	YicC-like family, N-terminal region
PBC10988_RS06810	COG0149	triose-phosphate isomerase activity
PBC10988_RS06815	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
PBC10988_RS06820	COG0077	Prephenate dehydratase
PBC10988_RS06820	COG1605	Chorismate mutase
PBC10988_RS06825	COG0443	Heat shock 70 kDa protein
PBC10988_RS06830	COG0542	response to heat
PBC10988_RS06845	COG0859	PFAM glycosyl transferase family 9
PBC10988_RS06865	COG1131	(ABC) transporter
PBC10988_RS06880	COG2124	cytochrome p450
PBC10988_RS06890	COG0469	pyruvate kinase activity
PBC10988_RS06900	COG4974	Belongs to the 'phage' integrase family
PBC10988_RS06905	COG1597	lipid kinase activity
PBC10988_RS06920	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
PBC10988_RS06950	COG1136	(ABC) transporter
PBC10988_RS06955	COG1136	(ABC) transporter
PBC10988_RS06955	COG0577	efflux transmembrane transporter activity
PBC10988_RS06975	COG4536	flavin adenine dinucleotide binding
PBC10988_RS06980	COG4536	flavin adenine dinucleotide binding
PBC10988_RS07000	COG0736	holo-[acyl-carrier-protein] synthase activity
PBC10988_RS07010	COG0180	Tryptophanyl-tRNA synthetase
PBC10988_RS07015	COG0167	dihydroorotate dehydrogenase activity
PBC10988_RS07025	COG0776	regulation of translation
PBC10988_RS07035	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
PBC10988_RS07040	COG1217	gtp-binding protein TYPA
PBC10988_RS07065	COG1595	DNA-templated transcription, initiation
PBC10988_RS07075	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
PBC10988_RS07080	COG0509	glycine decarboxylation via glycine cleavage system
PBC10988_RS07085	COG0404	The glycine cleavage system catalyzes the degradation of glycine
PBC10988_RS07090	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
PBC10988_RS07105	COG0148	phosphopyruvate hydratase activity
PBC10988_RS07115	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
PBC10988_RS07120	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
PBC10988_RS07130	COG0442	prolyl-tRNA aminoacylation
PBC10988_RS07145	COG0525	valine-tRNA ligase activity
PBC10988_RS07150	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
PBC10988_RS07160	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
PBC10988_RS07185	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PBC10988_RS07200	COG4251	negative regulation of phosphorylation
PBC10988_RS07205	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
PBC10988_RS07210	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
PBC10988_RS07215	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
PBC10988_RS07220	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
PBC10988_RS07225	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
PBC10988_RS07245	COG0686	Belongs to the AlaDH PNT family
PBC10988_RS07250	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
PBC10988_RS07270	COG0735	belongs to the Fur family
PBC10988_RS07325	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
PBC10988_RS07335	COG0220	tRNA (guanine-N7-)-methyltransferase activity
PBC10988_RS07355	COG0432	Pfam Uncharacterised protein family UPF0047
PBC10988_RS07365	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PBC10988_RS07375	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
PBC10988_RS07380	COG2252	PERMEase
PBC10988_RS07395	COG1454	alcohol dehydrogenase
PBC10988_RS07400	COG0745	RESPONSE REGULATOR receiver
PBC10988_RS07405	COG5002	protein histidine kinase activity
PBC10988_RS07455	COG2815	serine threonine protein kinase
PBC10988_RS07455	COG0515	serine threonine protein kinase
PBC10988_RS07465	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
PBC10988_RS07470	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PBC10988_RS07475	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
PBC10988_RS07480	COG2255	four-way junction helicase activity
PBC10988_RS07495	COG0632	four-way junction helicase activity
PBC10988_RS07500	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
PBC10988_RS07510	COG1131	(ABC) transporter
PBC10988_RS07530	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
PBC10988_RS07530	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
PBC10988_RS07535	COG0237	dephospho-CoA kinase activity
PBC10988_RS07540	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
PBC10988_RS07550	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
PBC10988_RS07555	COG0552	protein localization to endoplasmic reticulum
PBC10988_RS07570	COG0805	protein transport
PBC10988_RS07575	COG1482	cell wall glycoprotein biosynthetic process
PBC10988_RS07580	COG0004	ammonium transporteR
PBC10988_RS07585	COG0347	Belongs to the P(II) protein family
PBC10988_RS07595	COG1597	lipid kinase activity
PBC10988_RS07600	COG2877	3-deoxy-8-phosphooctulonate synthase activity
PBC10988_RS07610	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
PBC10988_RS07625	COG0673	inositol 2-dehydrogenase activity
PBC10988_RS07630	COG1609	Transcriptional regulator
PBC10988_RS07630	COG2207	Transcriptional regulator
PBC10988_RS07655	COG0561	phosphatase activity
PBC10988_RS07670	COG1108	ABC-type Mn2 Zn2 transport systems permease components
PBC10988_RS07675	COG1121	(ABC) transporter
PBC10988_RS07715	COG2957	Belongs to the agmatine deiminase family
PBC10988_RS07720	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PBC10988_RS07725	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
PBC10988_RS07730	COG1449	Belongs to the glycosyl hydrolase 57 family
PBC10988_RS07750	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PBC10988_RS07755	COG0436	Aminotransferase
PBC10988_RS07765	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
PBC10988_RS07775	COG0101	tRNA pseudouridine synthase activity
PBC10988_RS07785	COG0825	malonyl-CoA metabolic process
PBC10988_RS07805	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
PBC10988_RS07815	COG0227	Belongs to the bacterial ribosomal protein bL28 family
PBC10988_RS07820	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
PBC10988_RS07825	COG0154	amidase activity
PBC10988_RS07830	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
PBC10988_RS07845	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
PBC10988_RS07850	COG0518	GMP synthase (glutamine-hydrolyzing) activity
PBC10988_RS07850	COG0519	Catalyzes the synthesis of GMP from XMP
PBC10988_RS07865	COG4948	Mandelate Racemase Muconate Lactonizing
PBC10988_RS07880	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
PBC10988_RS07885	COG0515	serine threonine protein kinase
PBC10988_RS07885	COG2815	serine threonine protein kinase
PBC10988_RS07895	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
PBC10988_RS07985	COG1164	Oligoendopeptidase f
PBC10988_RS07990	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
PBC10988_RS08000	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
PBC10988_RS08005	COG1376	ErfK ybiS ycfS ynhG family protein
PBC10988_RS08015	COG2268	Band 7 protein
PBC10988_RS08040	COG2815	serine threonine protein kinase
PBC10988_RS08040	COG0515	serine threonine protein kinase
PBC10988_RS08050	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
PBC10988_RS08050	COG0457	Tetratricopeptide repeat
PBC10988_RS08060	COG0038	chloride channel
PBC10988_RS08105	COG1959	2 iron, 2 sulfur cluster binding
PBC10988_RS08110	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
PBC10988_RS08115	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
PBC10988_RS08130	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
PBC10988_RS08135	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
PBC10988_RS08140	COG1858	cytochrome C peroxidase
PBC10988_RS08145	COG0151	Belongs to the GarS family
PBC10988_RS08155	COG0285	dihydrofolate synthase activity
PBC10988_RS08160	COG0166	Belongs to the GPI family
PBC10988_RS08165	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
PBC10988_RS08205	COG0714	Associated with various cellular activities
PBC10988_RS08220	COG2322	membrane
PBC10988_RS08245	COG1845	cytochrome c oxidase, subunit III
PBC10988_RS08250	COG0109	protoheme IX farnesyltransferase activity
PBC10988_RS08260	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
PBC10988_RS08285	COG0257	Belongs to the bacterial ribosomal protein bL36 family
PBC10988_RS08335	COG4974	Belongs to the 'phage' integrase family
PBC10988_RS08340	COG3481	metal-dependent phosphohydrolase, HD sub domain
PBC10988_RS08345	COG2890	protein-(glutamine-N5) methyltransferase activity
PBC10988_RS08350	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
PBC10988_RS08355	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
PBC10988_RS08370	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
PBC10988_RS08380	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
PBC10988_RS08400	COG1254	Belongs to the acylphosphatase family
PBC10988_RS08410	COG0673	inositol 2-dehydrogenase activity
PBC10988_RS08415	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
PBC10988_RS08430	COG3852	Histidine kinase
PBC10988_RS08435	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PBC10988_RS08460	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PBC10988_RS08465	COG4980	gas vesicle protein
PBC10988_RS08465	COG1674	ftsk spoiiie
PBC10988_RS08485	COG2815	serine threonine protein kinase
PBC10988_RS08485	COG0515	serine threonine protein kinase
PBC10988_RS08500	COG1063	alcohol dehydrogenase
PBC10988_RS08515	COG1082	Xylose isomerase domain protein TIM barrel
PBC10988_RS08525	COG1069	ribulokinase activity
PBC10988_RS08530	COG1028	Short-chain dehydrogenase reductase Sdr
PBC10988_RS08535	COG0124	histidyl-tRNA synthetase
PBC10988_RS08555	COG0004	ammonium transporteR
PBC10988_RS08560	COG0515	serine threonine protein kinase
PBC10988_RS08570	COG0347	Belongs to the P(II) protein family
PBC10988_RS08575	COG3119	arylsulfatase activity
PBC10988_RS08595	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
PBC10988_RS08605	COG1595	DNA-templated transcription, initiation
PBC10988_RS08620	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
PBC10988_RS08625	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
PBC10988_RS08640	COG0515	serine threonine protein kinase
PBC10988_RS08640	COG2815	serine threonine protein kinase
PBC10988_RS08655	COG0275	rRNA processing
PBC10988_RS08700	COG0673	inositol 2-dehydrogenase activity
PBC10988_RS08710	COG2815	serine threonine protein kinase
PBC10988_RS08710	COG0515	serine threonine protein kinase
PBC10988_RS08715	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PBC10988_RS08740	COG0445	tRNA wobble uridine modification
PBC10988_RS08745	COG0626	cystathionine gamma-synthase activity
PBC10988_RS08760	COG0626	cystathionine gamma-synthase activity
PBC10988_RS08775	COG0037	tRNA processing
PBC10988_RS08785	COG1418	mRNA catabolic process
PBC10988_RS08790	COG1692	metallophosphoesterase
PBC10988_RS08825	COG0569	domain protein
PBC10988_RS08825	COG2985	domain, Protein
PBC10988_RS08830	COG0355	proton-transporting ATP synthase activity, rotational mechanism
PBC10988_RS08835	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
PBC10988_RS08840	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
PBC10988_RS08845	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
PBC10988_RS08850	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
PBC10988_RS08860	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
PBC10988_RS08865	COG0356	it plays a direct role in the translocation of protons across the membrane
PBC10988_RS08885	COG3386	PFAM SMP-30 Gluconolaconase
PBC10988_RS08890	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
PBC10988_RS08895	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
PBC10988_RS08900	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
PBC10988_RS08915	COG3119	arylsulfatase activity
PBC10988_RS08925	COG1691	(AIR) carboxylase
PBC10988_RS08930	COG2186	Transcriptional regulator
PBC10988_RS08935	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PBC10988_RS08940	COG2738	Putative neutral zinc metallopeptidase
PBC10988_RS08945	COG0443	Heat shock 70 kDa protein
PBC10988_RS08965	COG0443	Heat shock 70 kDa protein
PBC10988_RS08975	COG0443	Heat shock 70 kDa protein
PBC10988_RS08995	COG0517	IMP dehydrogenase activity
PBC10988_RS08995	COG1125	glycine betaine transport
PBC10988_RS09000	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
PBC10988_RS09020	COG2204	response regulator
PBC10988_RS09030	COG0793	Belongs to the peptidase S41A family
PBC10988_RS09065	COG1595	DNA-templated transcription, initiation
PBC10988_RS09120	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
PBC10988_RS09155	COG1678	Uncharacterized ACR, COG1678
PBC10988_RS09205	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
PBC10988_RS09225	COG1556	Lactate utilization protein
PBC10988_RS09235	COG1192	Involved in chromosome partitioning
PBC10988_RS09255	COG2815	serine threonine protein kinase
PBC10988_RS09255	COG0515	serine threonine protein kinase
PBC10988_RS09260	COG0484	heat shock protein binding
PBC10988_RS09265	COG0443	Heat shock 70 kDa protein
PBC10988_RS09275	COG3118	belongs to the thioredoxin family
PBC10988_RS09280	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
PBC10988_RS09290	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
PBC10988_RS09310	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PBC10988_RS09320	COG1294	oxidase, subunit
PBC10988_RS09325	COG1271	oxidase subunit
PBC10988_RS09350	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
PBC10988_RS09360	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
PBC10988_RS09410	COG1215	transferase activity, transferring glycosyl groups
PBC10988_RS09430	COG1012	belongs to the aldehyde dehydrogenase family
PBC10988_RS09435	COG1233	COG1233 Phytoene dehydrogenase and related
PBC10988_RS09445	COG0463	Glycosyl transferase, family 2
PBC10988_RS09455	COG2813	Specifically methylates the guanine in position
PBC10988_RS09455	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
PBC10988_RS09465	COG2204	response regulator
PBC10988_RS09480	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
PBC10988_RS09490	COG1131	(ABC) transporter
PBC10988_RS09540	COG0657	acetylesterase activity
PBC10988_RS09555	COG0436	Aminotransferase
PBC10988_RS09565	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
PBC10988_RS09580	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
PBC10988_RS09590	COG0095	Lipoate-protein ligase
PBC10988_RS09595	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
PBC10988_RS09615	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
PBC10988_RS09620	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PBC10988_RS09625	COG0604	alcohol dehydrogenase
PBC10988_RS09645	COG0515	serine threonine protein kinase
PBC10988_RS09645	COG2815	serine threonine protein kinase
PBC10988_RS09670	COG3119	arylsulfatase activity
PBC10988_RS09700	COG1309	transcriptional regulator
PBC10988_RS09715	COG1136	(ABC) transporter
PBC10988_RS09730	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PBC10988_RS09735	COG3938	Belongs to the proline racemase family
PBC10988_RS09740	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PBC10988_RS09745	COG3119	arylsulfatase activity
PBC10988_RS09800	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
PBC10988_RS09805	COG0446	pyridine nucleotide-disulphide oxidoreductase
PBC10988_RS09835	COG3119	arylsulfatase activity
PBC10988_RS09840	COG3119	arylsulfatase activity
PBC10988_RS09850	COG2814	Major facilitator Superfamily
PBC10988_RS09860	COG0656	L-ascorbic acid biosynthetic process
PBC10988_RS09865	COG1940	carbohydrate kinase activity
PBC10988_RS09925	COG3119	arylsulfatase activity
PBC10988_RS09930	COG0515	serine threonine protein kinase
PBC10988_RS09930	COG2815	serine threonine protein kinase
PBC10988_RS09965	COG2308	Evidence 4 Homologs of previously reported genes of
PBC10988_RS09970	COG0438	transferase activity, transferring glycosyl groups
PBC10988_RS09975	COG0720	synthase
PBC10988_RS09980	COG1469	GTP cyclohydrolase I activity
PBC10988_RS09995	COG0384	phenazine biosynthesis protein PhzF
PBC10988_RS10005	COG3119	arylsulfatase activity
PBC10988_RS10005	COG3408	Glycogen debranching enzyme
PBC10988_RS10020	COG0673	inositol 2-dehydrogenase activity
PBC10988_RS10025	COG2207	Transcriptional regulator
PBC10988_RS10025	COG1609	Transcriptional regulator
PBC10988_RS10045	COG1940	carbohydrate kinase activity
PBC10988_RS10050	COG1278	Cold shock
PBC10988_RS10060	COG0006	proline dipeptidase activity
PBC10988_RS10065	COG0745	RESPONSE REGULATOR receiver
PBC10988_RS10070	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
PBC10988_RS10075	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
PBC10988_RS10075	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
PBC10988_RS10080	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PBC10988_RS10085	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PBC10988_RS10090	COG0254	rRNA binding
PBC10988_RS10095	COG2166	iron-sulfur cluster assembly
PBC10988_RS10105	COG0129	dihydroxy-acid dehydratase activity
PBC10988_RS10110	COG1136	(ABC) transporter
PBC10988_RS10135	COG1262	PFAM Formylglycine-generating sulfatase enzyme
PBC10988_RS10135	COG0515	serine threonine protein kinase
PBC10988_RS10170	COG2197	response regulator
PBC10988_RS10180	COG3408	Glycogen debranching enzyme
PBC10988_RS10180	COG3119	arylsulfatase activity
PBC10988_RS10185	COG0673	inositol 2-dehydrogenase activity
PBC10988_RS10200	COG1231	oxidoreductase activity
PBC10988_RS10205	COG1028	Short-chain dehydrogenase reductase Sdr
PBC10988_RS10225	COG4585	Histidine kinase
PBC10988_RS10240	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
PBC10988_RS10270	COG1801	Protein of unknown function DUF72
PBC10988_RS10290	COG0347	Belongs to the P(II) protein family
PBC10988_RS10300	COG0004	ammonium transporteR
PBC10988_RS10305	COG1361	Conserved repeat domain
PBC10988_RS10330	COG2261	transglycosylase associated protein
PBC10988_RS10335	COG1028	Short-chain dehydrogenase reductase Sdr
PBC10988_RS10340	COG3046	protein related to deoxyribodipyrimidine photolyase
PBC10988_RS10345	COG1305	Transglutaminase-like
PBC10988_RS10350	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
PBC10988_RS10360	COG0714	Associated with various cellular activities
PBC10988_RS10385	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
PBC10988_RS10390	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PBC10988_RS10415	COG4537	Required for transformation and DNA binding
PBC10988_RS10440	COG1959	2 iron, 2 sulfur cluster binding
PBC10988_RS10445	COG0006	proline dipeptidase activity
PBC10988_RS10470	COG0714	Associated with various cellular activities
PBC10988_RS10485	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
PBC10988_RS10495	COG0494	nUDIX hydrolase
PBC10988_RS10510	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PBC10988_RS10535	COG1858	cytochrome C peroxidase
PBC10988_RS10570	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PBC10988_RS10575	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
PBC10988_RS10580	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PBC10988_RS10585	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
PBC10988_RS10680	COG0463	Glycosyl transferase, family 2
PBC10988_RS10685	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
PBC10988_RS10700	COG3119	arylsulfatase activity
PBC10988_RS10730	COG3119	arylsulfatase activity
PBC10988_RS10745	COG3119	arylsulfatase activity
PBC10988_RS10765	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
PBC10988_RS10875	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
PBC10988_RS10895	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
PBC10988_RS10900	COG0081	regulation of translation
PBC10988_RS10910	COG0222	ribosome binding
PBC10988_RS10915	COG0085	RNA polymerase activity
PBC10988_RS10920	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
PBC10988_RS10925	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
PBC10988_RS10930	COG0049	tRNA binding
PBC10988_RS10940	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PBC10988_RS10950	COG0123	including yeast histone deacetylase and acetoin utilization protein
PBC10988_RS10965	COG0539	negative regulation of cytoplasmic translation
PBC10988_RS10985	COG3119	arylsulfatase activity
PBC10988_RS11010	COG0095	Lipoate-protein ligase
PBC10988_RS11030	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
PBC10988_RS11030	COG0116	Belongs to the methyltransferase superfamily
PBC10988_RS11035	COG0673	inositol 2-dehydrogenase activity
PBC10988_RS11055	COG1090	epimerase
PBC10988_RS11070	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
PBC10988_RS11075	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PBC10988_RS11095	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PBC10988_RS11105	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PBC10988_RS11115	COG3119	arylsulfatase activity
PBC10988_RS11130	COG0640	Transcriptional regulator
PBC10988_RS11140	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
PBC10988_RS11145	COG0346	lactoylglutathione lyase activity
PBC10988_RS11150	COG4676	Protein conserved in bacteria
PBC10988_RS11155	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
PBC10988_RS11170	COG4336	lyase activity
PBC10988_RS11185	COG3119	arylsulfatase activity
PBC10988_RS11260	COG2183	response to ionizing radiation
PBC10988_RS11270	COG1611	Belongs to the LOG family
PBC10988_RS11280	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
PBC10988_RS11285	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
PBC10988_RS11290	COG1160	GTP binding
PBC10988_RS11295	COG1573	uracil-dna glycosylase
PBC10988_RS11310	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PBC10988_RS11370	COG0588	phosphoglycerate mutase activity
PBC10988_RS11390	COG0367	asparagine synthase
PBC10988_RS11395	COG1716	ATPase activity
PBC10988_RS11445	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
PBC10988_RS11450	COG1028	Short-chain dehydrogenase reductase Sdr
PBC10988_RS11455	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
PBC10988_RS11470	COG0657	acetylesterase activity
PBC10988_RS11490	COG1262	PFAM Formylglycine-generating sulfatase enzyme
PBC10988_RS11500	COG1070	Carbohydrate kinase
PBC10988_RS11515	COG3119	arylsulfatase activity
PBC10988_RS11520	COG3119	arylsulfatase activity
PBC10988_RS11525	COG0069	glutamate synthase activity
PBC10988_RS11525	COG0067	glutamate synthase
PBC10988_RS11525	COG0070	glutamate synthase
PBC10988_RS11530	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
PBC10988_RS11535	COG0737	Belongs to the 5'-nucleotidase family
PBC10988_RS11550	COG1477	protein flavinylation
PBC10988_RS11560	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
PBC10988_RS11565	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
PBC10988_RS11575	COG1805	sodium ion transport
PBC10988_RS11580	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
PBC10988_RS11620	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
PBC10988_RS11640	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
PBC10988_RS11645	COG0113	porphobilinogen synthase activity
PBC10988_RS11650	COG3119	arylsulfatase activity
PBC10988_RS11670	COG0247	lactate metabolic process
PBC10988_RS11675	COG1139	Iron-sulfur cluster binding protein
PBC10988_RS11685	COG2823	Periplasmic or secreted lipoprotein
PBC10988_RS11715	COG4948	Mandelate Racemase Muconate Lactonizing
PBC10988_RS11720	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
PBC10988_RS11760	COG0405	Gamma-glutamyltransferase
PBC10988_RS11775	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
PBC10988_RS11780	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
PBC10988_RS11785	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PBC10988_RS11790	COG0243	molybdopterin cofactor binding
PBC10988_RS11795	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
PBC10988_RS11800	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PBC10988_RS11805	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PBC10988_RS11805	COG1116	anion transmembrane transporter activity
PBC10988_RS11810	COG1116	anion transmembrane transporter activity
PBC10988_RS11815	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PBC10988_RS11820	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PBC10988_RS11820	COG1116	anion transmembrane transporter activity
PBC10988_RS11830	COG2204	response regulator
PBC10988_RS11835	COG2198	Histidine kinase
PBC10988_RS11835	COG2205	protein histidine kinase activity
PBC10988_RS11835	COG0784	Response regulator, receiver
PBC10988_RS11880	COG1921	L-seryl-tRNASec selenium transferase activity
PBC10988_RS11885	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
PBC10988_RS11895	COG0347	Belongs to the P(II) protein family
PBC10988_RS11920	COG1131	(ABC) transporter
PBC10988_RS11955	COG3119	arylsulfatase activity
PBC10988_RS11965	COG3119	arylsulfatase activity
PBC10988_RS11975	COG1253	flavin adenine dinucleotide binding
PBC10988_RS11990	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
PBC10988_RS12005	COG0508	dehydrogenase complex catalyzes the overall conversion of
PBC10988_RS12015	COG1082	Xylose isomerase domain protein TIM barrel
PBC10988_RS12040	COG0438	transferase activity, transferring glycosyl groups
PBC10988_RS12045	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
PBC10988_RS12055	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
PBC10988_RS12060	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
PBC10988_RS12065	COG1968	undecaprenyl-diphosphatase activity
PBC10988_RS12140	COG1234	tRNA 3'-trailer cleavage
PBC10988_RS12165	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
PBC10988_RS12170	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
PBC10988_RS12180	COG0492	ferredoxin-NADP+ reductase activity
PBC10988_RS12185	COG1028	Short-chain dehydrogenase reductase Sdr
PBC10988_RS12190	COG0655	NAD(P)H dehydrogenase (quinone) activity
PBC10988_RS12200	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PBC10988_RS12205	COG1902	pentaerythritol trinitrate reductase activity
PBC10988_RS12225	COG3119	arylsulfatase activity
PBC10988_RS12235	COG0175	sulfate reduction
PBC10988_RS12240	COG1959	2 iron, 2 sulfur cluster binding
PBC10988_RS12250	COG0529	Catalyzes the synthesis of activated sulfate
PBC10988_RS12280	COG3119	arylsulfatase activity
PBC10988_RS12315	COG3119	arylsulfatase activity
PBC10988_RS12320	COG1819	glycosyl
PBC10988_RS12400	COG1609	Transcriptional regulator
PBC10988_RS12410	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PBC10988_RS12420	COG1129	ABC transporter
PBC10988_RS12425	COG1172	Belongs to the binding-protein-dependent transport system permease family
PBC10988_RS12440	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
PBC10988_RS12440	COG2010	Cytochrome c
PBC10988_RS12445	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
PBC10988_RS12470	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
PBC10988_RS12485	COG3119	arylsulfatase activity
PBC10988_RS12510	COG2815	serine threonine protein kinase
PBC10988_RS12510	COG0515	serine threonine protein kinase
PBC10988_RS12530	COG3119	arylsulfatase activity
PBC10988_RS12535	COG3119	arylsulfatase activity
PBC10988_RS12540	COG3119	arylsulfatase activity
PBC10988_RS12590	COG0123	including yeast histone deacetylase and acetoin utilization protein
PBC10988_RS12595	COG0352	thiamine-phosphate diphosphorylase activity
PBC10988_RS12600	COG0657	acetylesterase activity
PBC10988_RS12600	COG2755	lipolytic protein G-D-S-L family
PBC10988_RS12605	COG0322	excinuclease ABC activity
PBC10988_RS12635	COG0657	acetylesterase activity
PBC10988_RS12645	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
PBC10988_RS12650	COG1174	glycine betaine transport
PBC10988_RS12660	COG0398	Pfam SNARE associated Golgi protein
PBC10988_RS12675	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
PBC10988_RS12675	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
PBC10988_RS12685	COG0438	transferase activity, transferring glycosyl groups
PBC10988_RS12695	COG4106	trans-aconitate 2-methyltransferase activity
PBC10988_RS12705	COG3119	arylsulfatase activity
PBC10988_RS12710	COG3119	arylsulfatase activity
PBC10988_RS12720	COG0612	Peptidase, M16
PBC10988_RS12735	COG1741	Belongs to the pirin family
PBC10988_RS12745	COG0783	Belongs to the Dps family
PBC10988_RS12765	COG3119	arylsulfatase activity
PBC10988_RS12770	COG3119	arylsulfatase activity
PBC10988_RS12775	COG3119	arylsulfatase activity
PBC10988_RS12840	COG0443	Heat shock 70 kDa protein
PBC10988_RS12850	COG0673	inositol 2-dehydrogenase activity
PBC10988_RS12855	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
PBC10988_RS12860	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
PBC10988_RS12880	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PBC10988_RS12900	COG0071	Belongs to the small heat shock protein (HSP20) family
PBC10988_RS12915	COG0134	indole-3-glycerol-phosphate synthase activity
PBC10988_RS12970	COG3552	Protein containing von Willebrand factor type A (VWA) domain
PBC10988_RS12980	COG0714	Associated with various cellular activities
PBC10988_RS13005	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PBC10988_RS13020	COG0545	Peptidyl-prolyl cis-trans isomerase
PBC10988_RS13030	COG3011	Protein conserved in bacteria
PBC10988_RS13035	COG0673	inositol 2-dehydrogenase activity
PBC10988_RS13060	COG1215	transferase activity, transferring glycosyl groups
PBC10988_RS13075	COG0438	transferase activity, transferring glycosyl groups
PBC10988_RS13100	COG0646	methionine synthase
PBC10988_RS13100	COG1410	methionine synthase
PBC10988_RS13110	COG1970	mechanosensitive ion channel activity
PBC10988_RS13120	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
PBC10988_RS13125	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
PBC10988_RS13135	COG0163	prenyltransferase activity
PBC10988_RS13145	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
PBC10988_RS13170	COG0714	Associated with various cellular activities
PBC10988_RS13185	COG2610	gluconate transmembrane transporter activity
PBC10988_RS13205	COG1215	transferase activity, transferring glycosyl groups
PBC10988_RS13240	COG0515	serine threonine protein kinase
PBC10988_RS13240	COG2815	serine threonine protein kinase
PBC10988_RS13245	COG1192	Involved in chromosome partitioning
PBC10988_RS13265	COG0138	bifunctional purine biosynthesis protein purh
PBC10988_RS13275	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
PBC10988_RS13290	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PBC10988_RS13295	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PBC10988_RS13310	COG2815	serine threonine protein kinase
PBC10988_RS13310	COG0515	serine threonine protein kinase
PBC10988_RS13315	COG0181	hydroxymethylbilane synthase activity
PBC10988_RS13325	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
PBC10988_RS13330	COG3119	arylsulfatase activity
PBC10988_RS13335	COG0084	hydrolase, TatD family'
PBC10988_RS13345	COG1007	ATP synthesis coupled electron transport
PBC10988_RS13360	COG0713	ATP synthesis coupled electron transport
PBC10988_RS13370	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
PBC10988_RS13375	COG0649	NAD binding
PBC10988_RS13380	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PBC10988_RS13385	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PBC10988_RS13390	COG3386	PFAM SMP-30 Gluconolaconase
PBC10988_RS13395	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
PBC10988_RS13400	COG0140	phosphoribosyl-ATP diphosphatase activity
PBC10988_RS13410	COG2815	serine threonine protein kinase
PBC10988_RS13410	COG0515	serine threonine protein kinase
PBC10988_RS13415	COG0154	amidase activity
PBC10988_RS13435	COG3119	arylsulfatase activity
PBC10988_RS13440	COG3119	arylsulfatase activity
PBC10988_RS13445	COG0515	serine threonine protein kinase
PBC10988_RS13445	COG2815	serine threonine protein kinase
PBC10988_RS13455	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PBC10988_RS13485	COG2226	methyltransferase
PBC10988_RS13515	COG0515	serine threonine protein kinase
PBC10988_RS13515	COG2815	serine threonine protein kinase
PBC10988_RS13545	COG2307	Protein conserved in bacteria
PBC10988_RS13545	COG2308	Evidence 4 Homologs of previously reported genes of
PBC10988_RS13565	COG0574	Belongs to the PEP-utilizing enzyme family
PBC10988_RS13565	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
PBC10988_RS13580	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
PBC10988_RS13585	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
PBC10988_RS13595	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PBC10988_RS13610	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
PBC10988_RS13630	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PBC10988_RS14000	COG1468	defense response to virus
PBC10988_RS14000	COG1518	maintenance of DNA repeat elements
PBC10988_RS14005	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
PBC10988_RS14015	COG4956	integral membrane protein (PIN domain superfamily)
PBC10988_RS14040	COG2815	serine threonine protein kinase
PBC10988_RS14040	COG0515	serine threonine protein kinase
PBC10988_RS14065	COG0811	peptide transport
PBC10988_RS14075	COG3318	Belongs to the UPF0149 family
PBC10988_RS14075	COG3012	SEC-C Motif Domain Protein
PBC10988_RS14105	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
PBC10988_RS14135	COG0673	inositol 2-dehydrogenase activity
PBC10988_RS14140	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
PBC10988_RS14145	COG1643	Atp-dependent helicase
PBC10988_RS14165	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
PBC10988_RS14170	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
PBC10988_RS14175	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
PBC10988_RS14190	COG1132	(ABC) transporter
PBC10988_RS14310	COG1609	Transcriptional regulator
PBC10988_RS14310	COG2207	Transcriptional regulator
PBC10988_RS14330	COG0521	Mo-molybdopterin cofactor biosynthetic process
PBC10988_RS14355	COG1032	radical SAM domain protein
PBC10988_RS14390	COG2379	hydroxypyruvate reductase
PBC10988_RS14410	COG0542	response to heat
PBC10988_RS14440	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
PBC10988_RS14460	COG0288	reversible hydration of carbon dioxide
PBC10988_RS14480	COG1716	ATPase activity
PBC10988_RS14485	COG0726	polysaccharide deacetylase
PBC10988_RS14495	COG1215	transferase activity, transferring glycosyl groups
PBC10988_RS14505	COG0438	transferase activity, transferring glycosyl groups
PBC10988_RS14510	COG0473	3-isopropylmalate dehydrogenase activity
PBC10988_RS14545	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
PBC10988_RS14550	COG4717	serine-type aminopeptidase activity
PBC10988_RS14555	COG0420	3'-5' exonuclease activity
PBC10988_RS14560	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
PBC10988_RS14565	COG1702	phosphate starvation-inducible protein PhoH
PBC10988_RS14575	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
PBC10988_RS14580	COG4535	Mg2 and Co2 transporter CorC
PBC10988_RS14585	COG1381	Involved in DNA repair and RecF pathway recombination
PBC10988_RS14610	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
PBC10988_RS14620	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PBC10988_RS14640	COG3119	arylsulfatase activity
PBC10988_RS14660	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PBC10988_RS14725	COG3119	arylsulfatase activity
PBC10988_RS14750	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
PBC10988_RS14770	COG3119	arylsulfatase activity
PBC10988_RS14805	COG1131	(ABC) transporter
PBC10988_RS14810	COG4221	oxidoreductase activity
PBC10988_RS14815	COG0277	FAD linked oxidase domain protein
PBC10988_RS14820	COG1078	dGTPase activity
PBC10988_RS14845	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
PBC10988_RS14905	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
PBC10988_RS14920	COG3852	Histidine kinase
PBC10988_RS14935	COG1185	polyribonucleotide nucleotidyltransferase activity
PBC10988_RS14940	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
PBC10988_RS14960	COG0564	pseudouridine synthase activity
PBC10988_RS14970	COG2815	serine threonine protein kinase
PBC10988_RS14970	COG0515	serine threonine protein kinase
PBC10988_RS14980	COG0443	Heat shock 70 kDa protein
PBC10988_RS14990	COG0438	transferase activity, transferring glycosyl groups
PBC10988_RS15005	COG3119	arylsulfatase activity
PBC10988_RS15015	COG0438	transferase activity, transferring glycosyl groups
PBC10988_RS15020	COG0641	radical SAM
PBC10988_RS15085	COG3119	arylsulfatase activity
PBC10988_RS15090	COG0354	folic acid binding
PBC10988_RS15095	COG0758	DNA mediated transformation
PBC10988_RS15100	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
PBC10988_RS15120	COG0515	serine threonine protein kinase
PBC10988_RS15120	COG2815	serine threonine protein kinase
PBC10988_RS15150	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
PBC10988_RS15155	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
PBC10988_RS15190	COG1242	4 iron, 4 sulfur cluster binding
PBC10988_RS15195	COG1162	GTPase activity
PBC10988_RS15350	COG4974	Belongs to the 'phage' integrase family
PBC10988_RS15360	COG2255	four-way junction helicase activity
PBC10988_RS15415	COG0515	serine threonine protein kinase
PBC10988_RS15440	COG1201	RNA secondary structure unwinding
PBC10988_RS15460	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
PBC10988_RS15500	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
PBC10988_RS15505	COG0210	DNA helicase
PBC10988_RS15605	COG3119	arylsulfatase activity
PBC10988_RS15620	COG0617	tRNA 3'-terminal CCA addition
PBC10988_RS15635	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
PBC10988_RS15665	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
PBC10988_RS15680	COG0515	serine threonine protein kinase
PBC10988_RS15685	COG1024	Enoyl-CoA hydratase
PBC10988_RS15690	COG1754	DNA topoisomerase type I activity
PBC10988_RS15690	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
PBC10988_RS15705	COG1104	cysteine desulfurase activity
PBC10988_RS15710	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
PBC10988_RS15715	COG0592	DNA-directed DNA polymerase activity
PBC10988_RS15725	COG0187	DNA topoisomerase II activity
PBC10988_RS15745	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
PBC10988_RS15765	COG0473	3-isopropylmalate dehydrogenase activity
PBC10988_RS15775	COG1132	(ABC) transporter
PBC10988_RS15785	COG3459	Glycosyltransferase 36 associated
PBC10988_RS15825	COG0024	Methionine aminopeptidase
PBC10988_RS15845	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PBC10988_RS15845	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PBC10988_RS15860	COG0531	amino acid
PBC10988_RS15865	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
PBC10988_RS15875	COG0728	peptidoglycan biosynthetic process
PBC10988_RS15925	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
PBC10988_RS15935	COG3119	arylsulfatase activity
PBC10988_RS15965	COG0515	serine threonine protein kinase
PBC10988_RS15965	COG2815	serine threonine protein kinase
PBC10988_RS16005	COG0698	ribose 5-phosphate isomerase
PBC10988_RS16010	COG0640	Transcriptional regulator
PBC10988_RS16050	COG1609	Transcriptional regulator
PBC10988_RS16050	COG2207	Transcriptional regulator
PBC10988_RS16055	COG3119	arylsulfatase activity
PBC10988_RS16060	COG3119	arylsulfatase activity
PBC10988_RS16070	COG3119	arylsulfatase activity
PBC10988_RS16075	COG3119	arylsulfatase activity
PBC10988_RS16080	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PBC10988_RS16085	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PBC10988_RS16115	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PBC10988_RS16125	COG0084	hydrolase, TatD family'
PBC10988_RS16130	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
PBC10988_RS16130	COG0517	IMP dehydrogenase activity
PBC10988_RS16135	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
PBC10988_RS16150	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
PBC10988_RS16165	COG0745	RESPONSE REGULATOR receiver
PBC10988_RS16175	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
PBC10988_RS16190	COG0859	PFAM glycosyl transferase family 9
PBC10988_RS16195	COG0438	transferase activity, transferring glycosyl groups
PBC10988_RS16230	COG2089	acid synthase
PBC10988_RS16270	COG0328	RNA-DNA hybrid ribonuclease activity
PBC10988_RS16275	COG2205	protein histidine kinase activity
PBC10988_RS16285	COG3119	arylsulfatase activity
PBC10988_RS16300	COG4112	unkown
PBC10988_RS16305	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
PBC10988_RS16320	COG2226	methyltransferase
PBC10988_RS16325	COG4206	TonB-dependent receptor
PBC10988_RS16350	COG5487	UPF0391 membrane protein
PBC10988_RS16360	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PBC10988_RS16365	COG1116	anion transmembrane transporter activity
PBC10988_RS16390	COG0488	(ABC) transporter
PBC10988_RS16420	COG2333	competence protein COMEC
PBC10988_RS16420	COG0658	competence protein
PBC10988_RS16430	COG0148	phosphopyruvate hydratase activity
PBC10988_RS16435	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
PBC10988_RS16445	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
PBC10988_RS16470	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PBC10988_RS16500	COG3119	arylsulfatase activity
PBC10988_RS16500	COG3119	arylsulfatase activity
PBC10988_RS16510	COG0131	Imidazoleglycerol-phosphate dehydratase
PBC10988_RS16515	COG0598	Magnesium transport protein CorA
PBC10988_RS16535	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
PBC10988_RS16645	COG0291	Belongs to the bacterial ribosomal protein bL35 family
PBC10988_RS16650	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
PBC10988_RS16655	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
PBC10988_RS16665	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
PBC10988_RS16680	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
PBC10988_RS16685	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
PBC10988_RS16690	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
PBC10988_RS16695	COG0211	Belongs to the bacterial ribosomal protein bL27 family
PBC10988_RS16710	COG1073	alpha beta
PBC10988_RS16750	COG0471	metal ion transport
PBC10988_RS16765	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
PBC10988_RS16770	COG1459	type II secretion system
PBC10988_RS16845	COG2890	protein-(glutamine-N5) methyltransferase activity
PBC10988_RS16865	COG0579	oxidoreductase
PBC10988_RS16885	COG3119	arylsulfatase activity
PBC10988_RS16890	COG3008	intermembrane lipid transfer
PBC10988_RS16895	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PBC10988_RS16935	COG0457	Tetratricopeptide repeat
PBC10988_RS16935	COG0515	serine threonine protein kinase
PBC10988_RS16940	COG0012	GTP binding
PBC10988_RS16950	COG4864	UPF0365 protein
PBC10988_RS16955	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
PBC10988_RS16965	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
PBC10988_RS16975	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
PBC10988_RS16980	COG1459	type II secretion system
PBC10988_RS17015	COG3119	arylsulfatase activity
PBC10988_RS17045	COG1511	domain protein
PBC10988_RS17045	COG3264	Mechanosensitive ion channel
PBC10988_RS17075	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
PBC10988_RS17090	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
PBC10988_RS17100	COG1663	tetraacyldisaccharide 4'-kinase activity
PBC10988_RS17130	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
PBC10988_RS17170	COG3852	Histidine kinase
PBC10988_RS17175	COG2204	response regulator
PBC10988_RS17180	COG4585	Histidine kinase
PBC10988_RS17205	COG2239	Acts as a magnesium transporter
PBC10988_RS17220	COG0828	Belongs to the bacterial ribosomal protein bS21 family
PBC10988_RS17245	COG0004	ammonium transporteR
PBC10988_RS17275	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
PBC10988_RS17280	COG0671	phosphoesterase, PA-phosphatase related
PBC10988_RS17315	COG2304	oxidoreductase activity
PBC10988_RS17335	COG0714	Associated with various cellular activities
PBC10988_RS17350	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PBC10988_RS17360	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
PBC10988_RS17370	COG1012	belongs to the aldehyde dehydrogenase family
PBC10988_RS17380	COG1366	Belongs to the anti-sigma-factor antagonist family
PBC10988_RS17420	COG0515	serine threonine protein kinase
PBC10988_RS17420	COG0457	Tetratricopeptide repeat
PBC10988_RS17425	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
PBC10988_RS17460	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PBC10988_RS17480	COG0745	RESPONSE REGULATOR receiver
PBC10988_RS17490	COG0515	serine threonine protein kinase
PBC10988_RS17490	COG2815	serine threonine protein kinase
PBC10988_RS17505	COG0784	Response regulator, receiver
PBC10988_RS17505	COG0643	Histidine kinase
PBC10988_RS17505	COG2198	Histidine kinase
PBC10988_RS17510	COG0840	transmembrane signaling receptor activity
PBC10988_RS17515	COG0835	chemotaxis
PBC10988_RS17530	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
PBC10988_RS17535	COG2197	response regulator
PBC10988_RS17555	COG0107	imidazoleglycerol-phosphate synthase activity
PBC10988_RS17580	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
PBC10988_RS17590	COG1252	NADH dehydrogenase
PBC10988_RS17610	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
PBC10988_RS17640	COG0450	alkyl hydroperoxide reductase
PBC10988_RS17645	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
PBC10988_RS17650	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
PBC10988_RS17650	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
PBC10988_RS17675	COG0203	ribosomal protein L17
PBC10988_RS17680	COG0202	RNA polymerase activity
PBC10988_RS17685	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
PBC10988_RS17690	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
PBC10988_RS17695	COG0563	adenylate kinase activity
PBC10988_RS17705	COG0200	Binds to the 23S rRNA
PBC10988_RS17710	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
PBC10988_RS17715	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
PBC10988_RS17720	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
PBC10988_RS17725	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
PBC10988_RS17730	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
PBC10988_RS17735	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
PBC10988_RS17740	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
PBC10988_RS17745	COG0255	Belongs to the universal ribosomal protein uL29 family
PBC10988_RS17750	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
PBC10988_RS17755	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
PBC10988_RS17760	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
PBC10988_RS17765	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
PBC10988_RS17770	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
PBC10988_RS17775	COG0089	rRNA binding
PBC10988_RS17780	COG0088	Forms part of the polypeptide exit tunnel
PBC10988_RS17785	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
PBC10988_RS17790	COG0051	transcription antitermination factor activity, RNA binding
PBC10988_RS17795	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
PBC10988_RS17810	COG4191	Histidine kinase
PBC10988_RS17815	COG0820	rRNA (adenine-C2-)-methyltransferase activity
PBC10988_RS17855	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
PBC10988_RS17865	COG2309	aminopeptidase activity
PBC10988_RS17870	COG0357	Ribosomal RNA small subunit methyltransferase G
PBC10988_RS17880	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
PBC10988_RS17895	COG1011	Hydrolase
PBC10988_RS17945	COG3852	Histidine kinase
PBC10988_RS17980	COG0482	sulfurtransferase activity
PBC10988_RS17985	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
PBC10988_RS17990	COG2319	Wd-40 repeat
PBC10988_RS17990	COG4249	Peptidase C14 caspase catalytic subunit p20
PBC10988_RS18010	COG2815	serine threonine protein kinase
PBC10988_RS18010	COG0515	serine threonine protein kinase
PBC10988_RS18015	COG0440	acetolactate synthase activity
PBC10988_RS18020	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
PBC10988_RS18035	COG0459	protein refolding
PBC10988_RS18040	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
PBC10988_RS18045	COG2226	methyltransferase
PBC10988_RS18050	COG3494	Protein of unknown function (DUF1009)
PBC10988_RS18055	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PBC10988_RS18065	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
PBC10988_RS18070	COG0072	phenylalanine-tRNA ligase activity
PBC10988_RS18080	COG0322	excinuclease ABC activity
PBC10988_RS18090	COG0668	transmembrane transport
PBC10988_RS18100	COG0515	serine threonine protein kinase
PBC10988_RS18100	COG2815	serine threonine protein kinase
PBC10988_RS18120	COG0471	metal ion transport
PBC10988_RS18120	COG3273	potassium ion transport
PBC10988_RS18140	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PBC10988_RS18150	COG2271	Major facilitator Superfamily
PBC10988_RS18160	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
PBC10988_RS18165	COG0473	3-isopropylmalate dehydrogenase activity
PBC10988_RS18180	COG1028	Short-chain dehydrogenase reductase Sdr
PBC10988_RS18190	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PBC10988_RS18215	COG3119	arylsulfatase activity
PBC10988_RS18235	COG3119	arylsulfatase activity
PBC10988_RS18240	COG0673	inositol 2-dehydrogenase activity
PBC10988_RS18265	COG0215	cysteine-tRNA ligase activity
PBC10988_RS18280	COG1191	sigma factor activity
PBC10988_RS18290	COG1419	protein localization to endoplasmic reticulum
PBC10988_RS18295	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
PBC10988_RS18335	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
PBC10988_RS18340	COG0706	membrane insertase activity
PBC10988_RS18340	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PBC10988_RS18350	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
PBC10988_RS18355	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
PBC10988_RS18365	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
PBC10988_RS18370	COG1214	PFAM Peptidase M22, glycoprotease
PBC10988_RS18375	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
PBC10988_RS18400	COG0653	protein targeting
PBC10988_RS18420	COG1519	Transferase
PBC10988_RS18425	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
PBC10988_RS18435	COG2815	serine threonine protein kinase
PBC10988_RS18435	COG0515	serine threonine protein kinase
PBC10988_RS18440	COG1058	Belongs to the CinA family
PBC10988_RS18440	COG1546	Belongs to the CinA family
PBC10988_RS18455	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
PBC10988_RS18465	COG0519	Catalyzes the synthesis of GMP from XMP
PBC10988_RS18480	COG0367	asparagine synthase
PBC10988_RS18490	COG1363	Peptidase, m42
PBC10988_RS18500	COG2382	esterase
PBC10988_RS18515	COG3119	arylsulfatase activity
PBC10988_RS18520	COG1609	Transcriptional regulator
PBC10988_RS18565	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PBC10988_RS18575	COG5002	protein histidine kinase activity
PBC10988_RS18590	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
PBC10988_RS18595	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
PBC10988_RS18600	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
PBC10988_RS18610	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
PBC10988_RS18625	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
PBC10988_RS18635	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PBC10988_RS18640	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PBC10988_RS18655	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
PBC10988_RS18660	COG0793	Belongs to the peptidase S41A family
PBC10988_RS18675	COG3604	Transcriptional regulator
PBC10988_RS18725	COG1940	carbohydrate kinase activity
PBC10988_RS18730	COG0481	GTPase activity
PBC10988_RS18735	COG0681	Belongs to the peptidase S26 family
PBC10988_RS18745	COG1137	ATPase activity
PBC10988_RS18750	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
PBC10988_RS18755	COG0406	alpha-ribazole phosphatase activity
PBC10988_RS18765	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
PBC10988_RS18775	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
PBC10988_RS18805	COG2204	response regulator
PBC10988_RS18820	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
PBC10988_RS18830	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
PBC10988_RS18845	COG0698	ribose 5-phosphate isomerase
PBC10988_RS18850	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
PBC10988_RS18860	COG1028	Short-chain dehydrogenase reductase Sdr
PBC10988_RS18880	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
PBC10988_RS18905	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
PBC10988_RS18975	COG1966	Carbon starvation protein
PBC10988_RS18990	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
PBC10988_RS19005	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PBC10988_RS19055	COG0006	proline dipeptidase activity
PBC10988_RS19065	COG0463	Glycosyl transferase, family 2
PBC10988_RS19085	COG0811	peptide transport
PBC10988_RS19095	COG0848	biopolymer transport protein
PBC10988_RS19120	COG4166	transmembrane transport
PBC10988_RS19125	COG0601	transmembrane transport
PBC10988_RS19130	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PBC10988_RS19135	COG0444	Belongs to the ABC transporter superfamily
PBC10988_RS19140	COG4608	Belongs to the ABC transporter superfamily
PBC10988_RS19150	COG3119	arylsulfatase activity
PBC10988_RS19180	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
PBC10988_RS19195	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
PBC10988_RS19220	COG2080	2 iron, 2 sulfur cluster binding
PBC10988_RS19225	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
PBC10988_RS19230	COG1529	Aldehyde oxidase and xanthine dehydrogenase
PBC10988_RS19235	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
PBC10988_RS19310	COG3119	arylsulfatase activity
PBC10988_RS19320	COG0673	inositol 2-dehydrogenase activity
PBC10988_RS19325	COG0492	ferredoxin-NADP+ reductase activity
PBC10988_RS19370	COG0823	Involved in the tonB-independent uptake of proteins
PBC10988_RS19390	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
PBC10988_RS19395	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PBC10988_RS19415	COG0483	inositol monophosphate 1-phosphatase activity
PBC10988_RS19420	COG1595	DNA-templated transcription, initiation
PBC10988_RS19455	COG0714	Associated with various cellular activities
PBC10988_RS19465	COG0693	protein deglycase activity
PBC10988_RS19470	COG1262	PFAM Formylglycine-generating sulfatase enzyme
PBC10988_RS19490	COG0243	molybdopterin cofactor binding
PBC10988_RS19505	COG4166	transmembrane transport
PBC10988_RS19510	COG0601	transmembrane transport
PBC10988_RS19515	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PBC10988_RS19520	COG4172	Belongs to the ABC transporter superfamily
PBC10988_RS19540	COG1595	DNA-templated transcription, initiation
PBC10988_RS19570	COG0135	phosphoribosylanthranilate isomerase activity
PBC10988_RS19610	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
PBC10988_RS19615	COG0045	succinate-CoA ligase (ADP-forming) activity
PBC10988_RS19620	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
PBC10988_RS19665	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
PBC10988_RS19675	COG0673	inositol 2-dehydrogenase activity
PBC10988_RS19690	COG1216	Glycosyl transferase, family 2
PBC10988_RS19705	COG0495	leucyl-tRNA aminoacylation
PBC10988_RS19710	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PBC10988_RS19715	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PBC10988_RS19720	COG1233	COG1233 Phytoene dehydrogenase and related
PBC10988_RS19740	COG1028	Short-chain dehydrogenase reductase Sdr
PBC10988_RS19745	COG2815	serine threonine protein kinase
PBC10988_RS19745	COG0515	serine threonine protein kinase
PBC10988_RS19770	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
PBC10988_RS19775	COG0504	CTP synthase activity
PBC10988_RS19795	COG0179	Fumarylacetoacetate (FAA) hydrolase
PBC10988_RS19810	COG2719	SpoVR family
PBC10988_RS19815	COG2718	Belongs to the UPF0229 family
PBC10988_RS19820	COG2766	serine protein kinase
PBC10988_RS19845	COG3253	May function as heme-dependent peroxidase
PBC10988_RS19875	COG0673	inositol 2-dehydrogenase activity
PBC10988_RS19920	COG0514	ATP-dependent DNA helicase (RecQ)
PBC10988_RS19960	COG1262	PFAM Formylglycine-generating sulfatase enzyme
PBC10988_RS19985	COG4591	ABC-type transport system involved in lipoprotein release permease component
PBC10988_RS19990	COG1136	(ABC) transporter
PBC10988_RS20005	COG2815	serine threonine protein kinase
PBC10988_RS20005	COG0515	serine threonine protein kinase
PBC10988_RS20010	COG0438	transferase activity, transferring glycosyl groups
PBC10988_RS20050	COG3012	SEC-C Motif Domain Protein
PBC10988_RS20065	COG0165	Argininosuccinate lyase
PBC10988_RS20070	COG2815	serine threonine protein kinase
PBC10988_RS20070	COG0515	serine threonine protein kinase
PBC10988_RS20090	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PBC10988_RS20100	COG0114	fumarate hydratase activity
PBC10988_RS20130	COG0714	Associated with various cellular activities
PBC10988_RS20155	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PBC10988_RS20160	COG0438	transferase activity, transferring glycosyl groups
PBC10988_RS20165	COG0561	phosphatase activity
PBC10988_RS20185	COG0635	Involved in the biosynthesis of porphyrin-containing compound
PBC10988_RS20200	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
PBC10988_RS20235	COG0534	Mate efflux family protein
PBC10988_RS20250	COG3546	catalase activity
PBC10988_RS20265	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PBC10988_RS20275	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
PBC10988_RS20285	COG2267	carboxylic ester hydrolase activity
PBC10988_RS20305	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
PBC10988_RS20345	COG1082	Xylose isomerase domain protein TIM barrel
PBC10988_RS20350	COG2189	Belongs to the N(4) N(6)-methyltransferase family
PBC10988_RS20380	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
PBC10988_RS20385	COG0193	aminoacyl-tRNA hydrolase activity
PBC10988_RS20390	COG0360	Binds together with S18 to 16S ribosomal RNA
PBC10988_RS20395	COG0629	single-stranded DNA binding
PBC10988_RS20400	COG0359	binds to the 23S rRNA
PBC10988_RS20405	COG0305	Participates in initiation and elongation during chromosome replication
PBC10988_RS20410	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
PBC10988_RS20415	COG0515	serine threonine protein kinase
PBC10988_RS20415	COG2815	serine threonine protein kinase
PBC10988_RS20450	COG5444	nuclease activity
PBC10988_RS20480	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
PBC10988_RS20485	COG0363	glucosamine-6-phosphate deaminase activity
PBC10988_RS20500	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PBC10988_RS20505	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PBC10988_RS20510	COG1028	Short-chain dehydrogenase reductase Sdr
PBC10988_RS20515	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
PBC10988_RS20520	COG0416	fatty acid biosynthetic process
PBC10988_RS20525	COG0333	Belongs to the bacterial ribosomal protein bL32 family
PBC10988_RS20545	COG3119	arylsulfatase activity
PBC10988_RS20550	COG3119	arylsulfatase activity
PBC10988_RS20555	COG0477	Major facilitator Superfamily
PBC10988_RS20560	COG3541	Predicted nucleotidyltransferase
PBC10988_RS20570	COG2211	Major facilitator Superfamily
PBC10988_RS20670	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
PBC10988_RS20675	COG1518	maintenance of DNA repeat elements
PBC10988_RS20675	COG1468	defense response to virus
PBC10988_RS20710	COG2378	regulation of single-species biofilm formation
PBC10988_RS20775	COG3591	Belongs to the peptidase S1B family
PBC10988_RS20775	COG1864	DNA RNA non-specific endonuclease
PBC10988_RS20930	COG0210	DNA helicase
PBC10988_RS20950	COG2801	Transposase and inactivated derivatives
PBC10988_RS20955	COG2963	transposase activity
PBC10988_RS20990	COG1674	ftsk spoiiie
PBC10988_RS21010	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
PBC10988_RS21015	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
PBC10988_RS21055	COG0483	inositol monophosphate 1-phosphatase activity
PBC10988_RS21095	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PBC10988_RS21100	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
PBC10988_RS21125	COG0515	serine threonine protein kinase
PBC10988_RS21125	COG2815	serine threonine protein kinase
PBC10988_RS21130	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
PBC10988_RS21140	COG0750	zinc metalloprotease
PBC10988_RS21140	COG0750	zinc metalloprotease
PBC10988_RS21145	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
PBC10988_RS21150	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PBC10988_RS21160	COG0303	'Molybdopterin
PBC10988_RS21170	COG3132	Protein of unknown function, DUF480
PBC10988_RS21200	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
PBC10988_RS21205	COG0328	RNA-DNA hybrid ribonuclease activity
PBC10988_RS21230	COG1091	dTDP-4-dehydrorhamnose reductase activity
PBC10988_RS21250	COG1216	Glycosyl transferase, family 2
PBC10988_RS21250	COG0438	transferase activity, transferring glycosyl groups
PBC10988_RS21275	COG0515	serine threonine protein kinase
PBC10988_RS21275	COG2815	serine threonine protein kinase
PBC10988_RS21290	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PBC10988_RS21310	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
PBC10988_RS21335	COG1012	belongs to the aldehyde dehydrogenase family
PBC10988_RS21355	COG0792	nuclease activity
PBC10988_RS21360	COG0335	large ribosomal subunit rRNA binding
PBC10988_RS21365	COG0336	Belongs to the RNA methyltransferase TrmD family
PBC10988_RS21370	COG0228	four-way junction DNA binding
PBC10988_RS21375	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
PBC10988_RS21400	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PBC10988_RS21405	COG0505	Belongs to the CarA family
PBC10988_RS21445	COG2706	6-phosphogluconolactonase activity
PBC10988_RS21460	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
PBC10988_RS21470	COG0284	orotidine-5'-phosphate decarboxylase activity
PBC10988_RS21475	COG0105	UTP biosynthetic process
PBC10988_RS21480	COG0745	RESPONSE REGULATOR receiver
PBC10988_RS21495	COG0573	inorganic phosphate transmembrane transporter activity
PBC10988_RS21500	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
PBC10988_RS21505	COG0704	Plays a role in the regulation of phosphate uptake
PBC10988_RS21510	COG0745	RESPONSE REGULATOR receiver
PBC10988_RS21535	COG0714	Associated with various cellular activities
PBC10988_RS21575	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PBC10988_RS21580	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PBC10988_RS21585	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PBC10988_RS21605	COG0539	negative regulation of cytoplasmic translation
PBC10988_RS21610	COG0714	Associated with various cellular activities
PBC10988_RS21650	COG0018	arginyl-trna synthetase
PBC10988_RS21655	COG0515	serine threonine protein kinase
PBC10988_RS21655	COG2815	serine threonine protein kinase
PBC10988_RS21660	COG4585	Histidine kinase
PBC10988_RS21775	COG2890	protein-(glutamine-N5) methyltransferase activity
PBC10988_RS21865	COG3119	arylsulfatase activity
PBC10988_RS21870	COG3119	arylsulfatase activity
PBC10988_RS21885	COG3119	arylsulfatase activity
PBC10988_RS21890	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
PBC10988_RS21895	COG3685	Protein conserved in bacteria
PBC10988_RS21915	COG4249	Peptidase C14 caspase catalytic subunit p20
PBC10988_RS21915	COG2319	Wd-40 repeat
PBC10988_RS21920	COG4249	Peptidase C14 caspase catalytic subunit p20
PBC10988_RS21920	COG2319	Wd-40 repeat
PBC10988_RS21930	COG1477	protein flavinylation
PBC10988_RS21945	COG0137	argininosuccinate synthase activity
PBC10988_RS21950	COG0469	pyruvate kinase activity
PBC10988_RS21955	COG2115	Belongs to the xylose isomerase family
PBC10988_RS21965	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
PBC10988_RS21995	COG3852	Histidine kinase
PBC10988_RS22000	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
PBC10988_RS22005	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
PBC10988_RS22015	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
PBC10988_RS22020	COG3217	Mosc domain protein beta barrel domain protein
PBC10988_RS22020	COG0633	Ferredoxin
PBC10988_RS22045	COG2815	serine threonine protein kinase
PBC10988_RS22045	COG0515	serine threonine protein kinase
PBC10988_RS22065	COG0515	serine threonine protein kinase
PBC10988_RS22065	COG2815	serine threonine protein kinase
PBC10988_RS22085	COG2346	COG2346, Truncated hemoglobins
PBC10988_RS22090	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
PBC10988_RS22100	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
PBC10988_RS22145	COG3119	arylsulfatase activity
PBC10988_RS22165	COG0430	RNA-3'-phosphate cyclase activity
PBC10988_RS22170	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
PBC10988_RS22190	COG0436	Aminotransferase
PBC10988_RS22200	COG0261	This protein binds to 23S rRNA in the presence of protein L20
PBC10988_RS22205	COG1530	ribonuclease E activity
PBC10988_RS22215	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
PBC10988_RS22255	COG0515	serine threonine protein kinase
PBC10988_RS22255	COG0457	Tetratricopeptide repeat
PBC10988_RS22260	COG4251	negative regulation of phosphorylation
PBC10988_RS22275	COG2186	Transcriptional regulator
PBC10988_RS22325	COG1845	cytochrome c oxidase, subunit III
PBC10988_RS22330	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
PBC10988_RS22365	COG0437	4 iron, 4 sulfur cluster binding
PBC10988_RS22455	COG5002	protein histidine kinase activity
PBC10988_RS22460	COG2204	response regulator
PBC10988_RS22470	COG1131	(ABC) transporter
PBC10988_RS22485	COG0039	L-malate dehydrogenase activity
PBC10988_RS22500	COG1082	Xylose isomerase domain protein TIM barrel
PBC10988_RS22505	COG3119	arylsulfatase activity
PBC10988_RS22520	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
PBC10988_RS22530	COG2204	response regulator
PBC10988_RS22540	COG0165	Argininosuccinate lyase
PBC10988_RS22545	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
PBC10988_RS22555	COG0463	Glycosyl transferase, family 2
PBC10988_RS22575	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
PBC10988_RS22585	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PBC10988_RS22595	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
PBC10988_RS22615	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
PBC10988_RS22620	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
PBC10988_RS22625	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
PBC10988_RS22630	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
PBC10988_RS22645	COG0784	Response regulator, receiver
PBC10988_RS22660	COG0693	protein deglycase activity
PBC10988_RS22680	COG0740	serine-type endopeptidase activity
PBC10988_RS22685	COG0740	serine-type endopeptidase activity
PBC10988_RS22690	COG0544	peptidyl-prolyl cis-trans isomerase activity
PBC10988_RS22715	COG1028	Short-chain dehydrogenase reductase Sdr
PBC10988_RS22725	COG0616	signal peptide processing
PBC10988_RS22730	COG1321	iron dependent repressor
PBC10988_RS22745	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
PBC10988_RS22750	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
PBC10988_RS22760	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
PBC10988_RS22775	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
PBC10988_RS22785	COG2226	methyltransferase
PBC10988_RS22815	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
PBC10988_RS22820	COG0195	Participates in both transcription termination and antitermination
PBC10988_RS22825	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
PBC10988_RS22825	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
PBC10988_RS22830	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
PBC10988_RS22845	COG0217	transcriptional regulatory protein
PBC10988_RS22895	COG0142	geranyltranstransferase activity
PBC10988_RS22900	COG1657	PFAM Prenyltransferase squalene oxidase
PBC10988_RS22910	COG0509	glycine decarboxylation via glycine cleavage system
PBC10988_RS22915	COG0635	Involved in the biosynthesis of porphyrin-containing compound
PBC10988_RS22925	COG1454	alcohol dehydrogenase
PBC10988_RS22955	COG0519	Catalyzes the synthesis of GMP from XMP
PBC10988_RS23000	COG0653	protein targeting
PBC10988_RS23005	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
PBC10988_RS23015	COG2204	response regulator
PBC10988_RS23035	COG0716	FMN binding
PBC10988_RS23090	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
PBC10988_RS23105	COG0343	queuine tRNA-ribosyltransferase activity
PBC10988_RS23110	COG0202	RNA polymerase activity
PBC10988_RS23135	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
PBC10988_RS23140	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
PBC10988_RS23140	COG1796	DNA polymerase
PBC10988_RS23195	COG3263	regulation of cellular component size
PBC10988_RS23205	COG3622	Belongs to the hyi family
PBC10988_RS23220	COG0811	peptide transport
PBC10988_RS23225	COG0848	biopolymer transport protein
PBC10988_RS23235	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
PBC10988_RS23240	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
PBC10988_RS23290	COG3119	arylsulfatase activity
PBC10988_RS23295	COG0738	Major facilitator superfamily
PBC10988_RS23335	COG1595	DNA-templated transcription, initiation
PBC10988_RS23340	COG2815	serine threonine protein kinase
PBC10988_RS23340	COG0515	serine threonine protein kinase
PBC10988_RS23365	COG0316	Belongs to the HesB IscA family
PBC10988_RS23370	COG0052	Belongs to the universal ribosomal protein uS2 family
PBC10988_RS23375	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
PBC10988_RS23380	COG0528	UMP kinase activity
PBC10988_RS23385	COG0233	cytoplasmic translational termination
PBC10988_RS23430	COG0330	HflC and HflK could
PBC10988_RS23460	COG0424	maF-like protein
PBC10988_RS23465	COG0564	pseudouridine synthase activity
PBC10988_RS23470	COG0242	peptide deformylase activity
PBC10988_RS23475	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
PBC10988_RS23490	COG1063	alcohol dehydrogenase
PBC10988_RS23500	COG0235	Class ii aldolase
PBC10988_RS23510	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
PBC10988_RS23520	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
PBC10988_RS23525	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PBC10988_RS23575	COG0515	serine threonine protein kinase
PBC10988_RS23575	COG2815	serine threonine protein kinase
PBC10988_RS23590	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
PBC10988_RS23595	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PBC10988_RS23605	COG1215	transferase activity, transferring glycosyl groups
PBC10988_RS23615	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
PBC10988_RS23625	COG3119	arylsulfatase activity
PBC10988_RS23635	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
PBC10988_RS23650	COG0617	tRNA 3'-terminal CCA addition
PBC10988_RS23670	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
PBC10988_RS23675	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
PBC10988_RS23680	COG0577	efflux transmembrane transporter activity
PBC10988_RS23680	COG1136	(ABC) transporter
PBC10988_RS23685	COG1136	(ABC) transporter
PBC10988_RS23695	COG1657	PFAM Prenyltransferase squalene oxidase
PBC10988_RS23715	COG0714	Associated with various cellular activities
PBC10988_RS23750	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
PBC10988_RS23755	COG1127	ABC transporter
PBC10988_RS23765	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
PBC10988_RS23775	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
PBC10988_RS23780	COG3119	arylsulfatase activity
PBC10988_RS23795	COG2323	membrane
PBC10988_RS23800	COG3119	arylsulfatase activity
PBC10988_RS23805	COG0673	inositol 2-dehydrogenase activity
PBC10988_RS23815	COG1404	Belongs to the peptidase S8 family
PBC10988_RS23820	COG0571	ribonuclease III activity
PBC10988_RS23825	COG0527	aspartate kinase activity
PBC10988_RS23865	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
PBC10988_RS23875	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
PBC10988_RS23880	COG0484	heat shock protein binding
PBC10988_RS23885	COG0459	protein refolding
PBC10988_RS23890	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
PBC10988_RS23895	COG0459	protein refolding
PBC10988_RS23905	COG1363	Peptidase, m42
PBC10988_RS23945	COG0512	Glutamine amidotransferase of anthranilate synthase
PBC10988_RS23955	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
PBC10988_RS23965	COG0142	geranyltranstransferase activity
PBC10988_RS23985	COG2815	serine threonine protein kinase
PBC10988_RS23985	COG0515	serine threonine protein kinase
PBC10988_RS24005	COG0058	SHG alpha-glucan phosphorylase activity
PBC10988_RS24015	COG1385	rRNA (uridine-N3-)-methyltransferase activity
PBC10988_RS24025	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
PBC10988_RS24050	COG3119	arylsulfatase activity
PBC10988_RS24060	COG1606	tRNA processing
PBC10988_RS24070	COG2815	serine threonine protein kinase
PBC10988_RS24070	COG0515	serine threonine protein kinase
PBC10988_RS24075	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
PBC10988_RS24085	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
PBC10988_RS24160	COG3119	arylsulfatase activity
PBC10988_RS24170	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
PBC10988_RS24180	COG3695	enzyme binding
PBC10988_RS24190	COG0436	Aminotransferase
PBC10988_RS24195	COG2226	methyltransferase
PBC10988_RS24195	COG1073	alpha beta
PBC10988_RS24200	COG4106	trans-aconitate 2-methyltransferase activity
PBC10988_RS24205	COG1120	ATPase activity
PBC10988_RS24210	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PBC10988_RS24215	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
PBC10988_RS24220	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
PBC10988_RS24235	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PBC10988_RS24240	COG3119	arylsulfatase activity
PBC10988_RS24245	COG3119	arylsulfatase activity
PBC10988_RS24250	COG1959	2 iron, 2 sulfur cluster binding
PBC10988_RS24255	COG0443	Heat shock 70 kDa protein
PBC10988_RS24265	COG0156	8-amino-7-oxononanoate synthase activity
PBC10988_RS24325	COG2165	general secretion pathway protein
PBC10988_RS24330	COG1028	Short-chain dehydrogenase reductase Sdr
PBC10988_RS24340	COG1012	belongs to the aldehyde dehydrogenase family
PBC10988_RS24355	COG1994	Peptidase M50
PBC10988_RS24355	COG0517	IMP dehydrogenase activity
PBC10988_RS24365	COG0318	PFAM AMP-dependent synthetase and ligase
PBC10988_RS24365	COG0204	Acyl-transferase
PBC10988_RS24380	COG2204	response regulator
PBC10988_RS24385	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
PBC10988_RS24410	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
PBC10988_RS24420	COG3119	arylsulfatase activity
PBC10988_RS24440	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PBC10988_RS24480	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
PBC10988_RS24485	COG1872	DUF167
PBC10988_RS24500	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
PBC10988_RS24505	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PBC10988_RS24550	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PBC10988_RS24585	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)