locus-tag	class	description
Pan265_RS00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Pan265_RS00025	COG0745	RESPONSE REGULATOR receiver
Pan265_RS00030	COG3852	Histidine kinase
Pan265_RS00040	COG0165	Argininosuccinate lyase
Pan265_RS00045	COG5002	protein histidine kinase activity
Pan265_RS00060	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
Pan265_RS00080	COG0481	GTPase activity
Pan265_RS00140	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Pan265_RS00145	COG1459	type II secretion system
Pan265_RS00155	COG0187	DNA topoisomerase II activity
Pan265_RS00165	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Pan265_RS00170	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Pan265_RS00180	COG0693	protein deglycase activity
Pan265_RS00205	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Pan265_RS00220	COG2204	response regulator
Pan265_RS00225	COG0525	valine-tRNA ligase activity
Pan265_RS00230	COG0560	Phosphoserine phosphatase
Pan265_RS00230	COG3830	Belongs to the UPF0237 family
Pan265_RS00240	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Pan265_RS00265	COG1663	tetraacyldisaccharide 4'-kinase activity
Pan265_RS00270	COG0424	maF-like protein
Pan265_RS00275	COG1192	Involved in chromosome partitioning
Pan265_RS00295	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Pan265_RS00335	COG0423	glycine-tRNA ligase activity
Pan265_RS00350	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Pan265_RS00355	COG0585	pseudouridine synthase activity
Pan265_RS00365	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Pan265_RS00370	COG0052	Belongs to the universal ribosomal protein uS2 family
Pan265_RS00375	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Pan265_RS00380	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Pan265_RS00385	COG0489	protein tyrosine kinase activity
Pan265_RS00405	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Pan265_RS00415	COG0840	transmembrane signaling receptor activity
Pan265_RS00420	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Pan265_RS00440	COG0107	imidazoleglycerol-phosphate synthase activity
Pan265_RS00460	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Pan265_RS00465	COG0501	Belongs to the peptidase M48B family
Pan265_RS00510	COG3842	ATPase activity
Pan265_RS00530	COG1473	amidohydrolase
Pan265_RS00555	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Pan265_RS00565	COG0828	Belongs to the bacterial ribosomal protein bS21 family
Pan265_RS00570	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
Pan265_RS00585	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
Pan265_RS00620	COG0592	DNA-directed DNA polymerase activity
Pan265_RS00640	COG0463	Glycosyl transferase, family 2
Pan265_RS00650	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Pan265_RS00655	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Pan265_RS00680	COG2247	cell wall binding repeat
Pan265_RS00680	COG2385	sporulation resulting in formation of a cellular spore
Pan265_RS00685	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Pan265_RS00685	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
Pan265_RS00710	COG0028	Belongs to the TPP enzyme family
Pan265_RS00720	COG1595	DNA-templated transcription, initiation
Pan265_RS00725	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
Pan265_RS00730	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
Pan265_RS00735	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
Pan265_RS00750	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Pan265_RS00755	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Pan265_RS00770	COG2095	MarC family integral membrane protein
Pan265_RS00785	COG0405	Gamma-glutamyltransferase
Pan265_RS00790	COG1757	Na H antiporter
Pan265_RS00810	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Pan265_RS00815	COG0137	argininosuccinate synthase activity
Pan265_RS00830	COG1639	'signal transduction protein
Pan265_RS00840	COG0668	transmembrane transport
Pan265_RS00845	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Pan265_RS00890	COG0181	hydroxymethylbilane synthase activity
Pan265_RS00895	COG0149	triose-phosphate isomerase activity
Pan265_RS00905	COG1561	YicC-like family, N-terminal region
Pan265_RS00930	COG1674	ftsk spoiiie
Pan265_RS00935	COG0756	dUTP diphosphatase activity
Pan265_RS00940	COG0561	phosphatase activity
Pan265_RS00945	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Pan265_RS00955	COG0138	bifunctional purine biosynthesis protein purh
Pan265_RS00970	COG0653	protein targeting
Pan265_RS00975	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Pan265_RS00980	COG0632	four-way junction helicase activity
Pan265_RS00995	COG0492	ferredoxin-NADP+ reductase activity
Pan265_RS01015	COG4968	Prepilin-type N-terminal cleavage methylation domain
Pan265_RS01050	COG0724	RNA recognition motif
Pan265_RS01060	COG0250	Participates in transcription elongation, termination and antitermination
Pan265_RS01070	COG1322	Protein conserved in bacteria
Pan265_RS01095	COG1136	(ABC) transporter
Pan265_RS01095	COG0577	efflux transmembrane transporter activity
Pan265_RS01105	COG0778	Nitroreductase
Pan265_RS01110	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Pan265_RS01115	COG0686	Belongs to the AlaDH PNT family
Pan265_RS01130	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
Pan265_RS01135	COG1064	alcohol dehydrogenase
Pan265_RS01145	COG1523	belongs to the glycosyl hydrolase 13 family
Pan265_RS01170	COG1940	carbohydrate kinase activity
Pan265_RS01175	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
Pan265_RS01190	COG1174	glycine betaine transport
Pan265_RS01195	COG0517	IMP dehydrogenase activity
Pan265_RS01195	COG1125	glycine betaine transport
Pan265_RS01220	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Pan265_RS01225	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Pan265_RS01235	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
Pan265_RS01255	COG0783	Belongs to the Dps family
Pan265_RS01380	COG2814	Major facilitator Superfamily
Pan265_RS01390	COG2801	Transposase and inactivated derivatives
Pan265_RS01395	COG3547	Transposase (IS116 IS110 IS902 family)
Pan265_RS01430	COG1940	carbohydrate kinase activity
Pan265_RS01435	COG3525	Glycosyl hydrolase, family 20, catalytic domain
Pan265_RS01570	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Pan265_RS01650	COG0714	Associated with various cellular activities
Pan265_RS01680	COG2205	protein histidine kinase activity
Pan265_RS01685	COG0784	Response regulator, receiver
Pan265_RS01700	COG3693	PFAM glycoside hydrolase, family 10
Pan265_RS01710	COG2211	Major facilitator Superfamily
Pan265_RS01720	COG3119	arylsulfatase activity
Pan265_RS01725	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
Pan265_RS01730	COG1874	Beta-galactosidase
Pan265_RS01800	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
Pan265_RS01805	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Pan265_RS01810	COG0702	epimerase
Pan265_RS01845	COG1609	Transcriptional regulator
Pan265_RS01885	COG0395	ABC-type sugar transport system, permease component
Pan265_RS01920	COG2165	general secretion pathway protein
Pan265_RS01930	COG1288	antiporter activity
Pan265_RS01950	COG0657	acetylesterase activity
Pan265_RS01995	COG0673	inositol 2-dehydrogenase activity
Pan265_RS02020	COG0463	Glycosyl transferase, family 2
Pan265_RS02035	COG0667	Aldo Keto reductase
Pan265_RS02055	COG0840	transmembrane signaling receptor activity
Pan265_RS02075	COG1929	Belongs to the glycerate kinase type-1 family
Pan265_RS02080	COG0667	Aldo Keto reductase
Pan265_RS02115	COG0811	peptide transport
Pan265_RS02120	COG0811	peptide transport
Pan265_RS02125	COG0848	biopolymer transport protein
Pan265_RS02130	COG0848	biopolymer transport protein
Pan265_RS02155	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Pan265_RS02165	COG2165	general secretion pathway protein
Pan265_RS02210	COG1366	Belongs to the anti-sigma-factor antagonist family
Pan265_RS02220	COG3119	arylsulfatase activity
Pan265_RS02225	COG3119	arylsulfatase activity
Pan265_RS02230	COG3119	arylsulfatase activity
Pan265_RS02240	COG0383	alpha-mannosidase activity
Pan265_RS02290	COG1609	Transcriptional regulator
Pan265_RS02295	COG3119	arylsulfatase activity
Pan265_RS02300	COG4952	isomerase
Pan265_RS02305	COG1070	Carbohydrate kinase
Pan265_RS02310	COG3875	lactate racemase activity
Pan265_RS02330	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
Pan265_RS02380	COG0561	phosphatase activity
Pan265_RS02390	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Pan265_RS02400	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Pan265_RS02410	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Pan265_RS02415	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Pan265_RS02420	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
Pan265_RS02430	COG0617	tRNA 3'-terminal CCA addition
Pan265_RS02445	COG0515	serine threonine protein kinase
Pan265_RS02445	COG2815	serine threonine protein kinase
Pan265_RS02450	COG0658	competence protein
Pan265_RS02450	COG2333	competence protein COMEC
Pan265_RS02460	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Pan265_RS02465	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Pan265_RS02470	COG0321	lipoyl(octanoyl) transferase activity
Pan265_RS02490	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Pan265_RS02495	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Pan265_RS02500	COG0575	Belongs to the CDS family
Pan265_RS02515	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Pan265_RS02525	COG1217	gtp-binding protein TYPA
Pan265_RS02540	COG2165	general secretion pathway protein
Pan265_RS02555	COG3459	Glycosyltransferase 36 associated
Pan265_RS02565	COG1609	Transcriptional regulator
Pan265_RS02580	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Pan265_RS02600	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Pan265_RS02605	COG2089	acid synthase
Pan265_RS02615	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
Pan265_RS02635	COG0471	metal ion transport
Pan265_RS02635	COG3273	potassium ion transport
Pan265_RS02640	COG0529	Catalyzes the synthesis of activated sulfate
Pan265_RS02645	COG1218	3'(2'),5'-bisphosphate nucleotidase
Pan265_RS02650	COG0175	sulfate reduction
Pan265_RS02655	COG2895	sulfate adenylyltransferase (ATP) activity
Pan265_RS02655	COG0529	Catalyzes the synthesis of activated sulfate
Pan265_RS02665	COG0438	transferase activity, transferring glycosyl groups
Pan265_RS02690	COG4948	Mandelate Racemase Muconate Lactonizing
Pan265_RS02695	COG0673	inositol 2-dehydrogenase activity
Pan265_RS02705	COG0811	peptide transport
Pan265_RS02725	COG0667	Aldo Keto reductase
Pan265_RS02730	COG0494	nUDIX hydrolase
Pan265_RS02740	COG0343	queuine tRNA-ribosyltransferase activity
Pan265_RS02745	COG1862	Preprotein translocase
Pan265_RS02750	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Pan265_RS02755	COG0742	ribosomal rna small subunit methyltransferase
Pan265_RS02765	COG4566	intracellular signal transduction
Pan265_RS02770	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
Pan265_RS02775	COG0174	glutamine synthetase
Pan265_RS02780	COG3579	cysteine-type endopeptidase activity
Pan265_RS02795	COG0513	Belongs to the DEAD box helicase family
Pan265_RS02805	COG0626	cystathionine gamma-synthase activity
Pan265_RS02815	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
Pan265_RS02820	COG4948	Mandelate Racemase Muconate Lactonizing
Pan265_RS02830	COG0673	inositol 2-dehydrogenase activity
Pan265_RS02835	COG0667	Aldo Keto reductase
Pan265_RS02845	COG1609	Transcriptional regulator
Pan265_RS02860	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Pan265_RS02885	COG3250	beta-galactosidase activity
Pan265_RS02915	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
Pan265_RS02955	COG0805	protein transport
Pan265_RS02960	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Pan265_RS02990	COG0673	inositol 2-dehydrogenase activity
Pan265_RS03000	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Pan265_RS03010	COG0459	protein refolding
Pan265_RS03015	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Pan265_RS03025	COG0463	Glycosyl transferase, family 2
Pan265_RS03045	COG0544	peptidyl-prolyl cis-trans isomerase activity
Pan265_RS03075	COG4968	Prepilin-type N-terminal cleavage methylation domain
Pan265_RS03090	COG2515	1-aminocyclopropane-1-carboxylate deaminase
Pan265_RS03110	COG1215	transferase activity, transferring glycosyl groups
Pan265_RS03125	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
Pan265_RS03130	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
Pan265_RS03130	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
Pan265_RS03155	COG1012	belongs to the aldehyde dehydrogenase family
Pan265_RS03170	COG1215	transferase activity, transferring glycosyl groups
Pan265_RS03175	COG0259	pyridoxamine-phosphate oxidase activity
Pan265_RS03180	COG1187	pseudouridine synthase activity
Pan265_RS03205	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
Pan265_RS03220	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Pan265_RS03225	COG0196	riboflavin kinase activity
Pan265_RS03240	COG0717	Belongs to the dCTP deaminase family
Pan265_RS03245	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Pan265_RS03255	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Pan265_RS03260	COG1132	(ABC) transporter
Pan265_RS03270	COG1233	COG1233 Phytoene dehydrogenase and related
Pan265_RS03285	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Pan265_RS03300	COG0047	phosphoribosylformylglycinamidine synthase activity
Pan265_RS03305	COG2183	response to ionizing radiation
Pan265_RS03305	COG0539	negative regulation of cytoplasmic translation
Pan265_RS03315	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Pan265_RS03320	COG0793	Belongs to the peptidase S41A family
Pan265_RS03325	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Pan265_RS03335	COG0544	peptidyl-prolyl cis-trans isomerase activity
Pan265_RS03340	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
Pan265_RS03365	COG2205	protein histidine kinase activity
Pan265_RS03365	COG5002	protein histidine kinase activity
Pan265_RS03365	COG0784	Response regulator, receiver
Pan265_RS03385	COG1606	tRNA processing
Pan265_RS03395	COG3869	Catalyzes the specific phosphorylation of arginine residues in
Pan265_RS03405	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Pan265_RS03420	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Pan265_RS03425	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Pan265_RS03430	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Pan265_RS03435	COG0193	aminoacyl-tRNA hydrolase activity
Pan265_RS03445	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Pan265_RS03450	COG1131	(ABC) transporter
Pan265_RS03485	COG0109	protoheme IX farnesyltransferase activity
Pan265_RS03490	COG1612	heme a metabolic process
Pan265_RS03495	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Pan265_RS03500	COG0135	phosphoribosylanthranilate isomerase activity
Pan265_RS03510	COG0395	ABC-type sugar transport system, permease component
Pan265_RS03525	COG0402	S-adenosylhomocysteine deaminase activity
Pan265_RS03555	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Pan265_RS03565	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Pan265_RS03570	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Pan265_RS03595	COG0542	response to heat
Pan265_RS03610	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Pan265_RS03620	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Pan265_RS03625	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Pan265_RS03635	COG0129	dihydroxy-acid dehydratase activity
Pan265_RS03650	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Pan265_RS03665	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Pan265_RS03690	COG0163	prenyltransferase activity
Pan265_RS03710	COG0527	aspartate kinase activity
Pan265_RS03725	COG0395	ABC-type sugar transport system, permease component
Pan265_RS03730	COG1175	transmembrane transport
Pan265_RS03740	COG2165	general secretion pathway protein
Pan265_RS03745	COG2133	pyrroloquinoline quinone binding
Pan265_RS03770	COG1215	transferase activity, transferring glycosyl groups
Pan265_RS03775	COG2244	polysaccharide biosynthetic process
Pan265_RS03790	COG0641	radical SAM
Pan265_RS03820	COG1253	flavin adenine dinucleotide binding
Pan265_RS03825	COG1253	flavin adenine dinucleotide binding
Pan265_RS03830	COG0673	inositol 2-dehydrogenase activity
Pan265_RS03835	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
Pan265_RS03860	COG0202	RNA polymerase activity
Pan265_RS03900	COG1609	Transcriptional regulator
Pan265_RS03910	COG1175	transmembrane transport
Pan265_RS03915	COG0395	ABC-type sugar transport system, permease component
Pan265_RS03935	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Pan265_RS03945	COG1741	Belongs to the pirin family
Pan265_RS03970	COG0475	glutathione-regulated potassium exporter activity
Pan265_RS03990	COG0811	peptide transport
Pan265_RS04010	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Pan265_RS04015	COG0802	atpase or kinase
Pan265_RS04020	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
Pan265_RS04045	COG1045	serine acetyltransferase
Pan265_RS04075	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Pan265_RS04085	COG1090	epimerase
Pan265_RS04090	COG0415	Belongs to the DNA photolyase family
Pan265_RS04110	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Pan265_RS04115	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Pan265_RS04120	COG0706	membrane insertase activity
Pan265_RS04125	COG0750	zinc metalloprotease
Pan265_RS04130	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Pan265_RS04135	COG1530	ribonuclease E activity
Pan265_RS04145	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Pan265_RS04155	COG0114	fumarate hydratase activity
Pan265_RS04160	COG2755	lipolytic protein G-D-S-L family
Pan265_RS04160	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
Pan265_RS04165	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Pan265_RS04185	COG0275	rRNA processing
Pan265_RS04195	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Pan265_RS04195	COG1796	DNA polymerase
Pan265_RS04205	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
Pan265_RS04210	COG0444	Belongs to the ABC transporter superfamily
Pan265_RS04215	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Pan265_RS04220	COG0601	transmembrane transport
Pan265_RS04225	COG0747	negative chemotaxis
Pan265_RS04230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Pan265_RS04235	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
Pan265_RS04240	COG3119	arylsulfatase activity
Pan265_RS04245	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Pan265_RS04325	COG1609	Transcriptional regulator
Pan265_RS04335	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
Pan265_RS04480	COG3177	Filamentation induced by cAMP protein fic
Pan265_RS04485	COG1475	DNA binding
Pan265_RS04505	COG1061	Type III restriction enzyme res subunit
Pan265_RS04510	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
Pan265_RS04625	COG0674	pyruvate-flavodoxin oxidoreductase activity
Pan265_RS04625	COG1013	pyruvate-flavodoxin oxidoreductase activity
Pan265_RS04625	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Pan265_RS04630	COG0657	acetylesterase activity
Pan265_RS04640	COG2198	Histidine kinase
Pan265_RS04640	COG0784	Response regulator, receiver
Pan265_RS04640	COG5002	protein histidine kinase activity
Pan265_RS04675	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Pan265_RS04685	COG1538	Outer membrane efflux protein
Pan265_RS04695	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Pan265_RS04700	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Pan265_RS04705	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Pan265_RS04710	COG1028	Short-chain dehydrogenase reductase Sdr
Pan265_RS04715	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Pan265_RS04720	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Pan265_RS04735	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Pan265_RS04755	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Pan265_RS04760	COG1294	oxidase, subunit
Pan265_RS04765	COG1271	oxidase subunit
Pan265_RS04800	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Pan265_RS04815	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
Pan265_RS04820	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Pan265_RS04840	COG3876	Protein conserved in bacteria
Pan265_RS04850	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Pan265_RS04875	COG0488	(ABC) transporter
Pan265_RS04880	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Pan265_RS04885	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Pan265_RS04895	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Pan265_RS04910	COG1691	(AIR) carboxylase
Pan265_RS04915	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Pan265_RS04915	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Pan265_RS04930	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Pan265_RS04935	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Pan265_RS04960	COG4191	Histidine kinase
Pan265_RS04965	COG1278	Cold shock
Pan265_RS04970	COG1185	polyribonucleotide nucleotidyltransferase activity
Pan265_RS04975	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Pan265_RS04980	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Pan265_RS04985	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Pan265_RS04990	COG1959	2 iron, 2 sulfur cluster binding
Pan265_RS05000	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Pan265_RS05005	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Pan265_RS05015	COG1418	mRNA catabolic process
Pan265_RS05050	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Pan265_RS05055	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
Pan265_RS05085	COG0484	heat shock protein binding
Pan265_RS05090	COG0459	protein refolding
Pan265_RS05095	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Pan265_RS05100	COG0459	protein refolding
Pan265_RS05105	COG1643	Atp-dependent helicase
Pan265_RS05110	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Pan265_RS05120	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Pan265_RS05150	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Pan265_RS05155	COG0285	dihydrofolate synthase activity
Pan265_RS05160	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Pan265_RS05170	COG0066	3-isopropylmalate dehydratase activity
Pan265_RS05185	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Pan265_RS05190	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Pan265_RS05190	COG0519	Catalyzes the synthesis of GMP from XMP
Pan265_RS05200	COG1695	Transcriptional regulator
Pan265_RS05210	COG0442	prolyl-tRNA aminoacylation
Pan265_RS05215	COG2873	o-acetylhomoserine
Pan265_RS05220	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Pan265_RS05220	COG2813	Specifically methylates the guanine in position
Pan265_RS05225	COG0268	Binds directly to 16S ribosomal RNA
Pan265_RS05235	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Pan265_RS05240	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
Pan265_RS05245	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Pan265_RS05265	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
Pan265_RS05275	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Pan265_RS05290	COG0187	DNA topoisomerase II activity
Pan265_RS05300	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Pan265_RS05310	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Pan265_RS05320	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Pan265_RS05325	COG2251	uridine kinase activity
Pan265_RS05325	COG0195	Participates in both transcription termination and antitermination
Pan265_RS05350	COG0322	excinuclease ABC activity
Pan265_RS05360	COG1872	DUF167
Pan265_RS05365	COG0123	including yeast histone deacetylase and acetoin utilization protein
Pan265_RS05380	COG0546	phosphoglycolate phosphatase activity
Pan265_RS05385	COG0426	domain, Protein
Pan265_RS05385	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Pan265_RS05395	COG0101	tRNA pseudouridine synthase activity
Pan265_RS05405	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
Pan265_RS05410	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
Pan265_RS05440	COG0105	UTP biosynthetic process
Pan265_RS05470	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
Pan265_RS05475	COG1774	PSP1 C-terminal conserved region
Pan265_RS05485	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Pan265_RS05495	COG0443	Heat shock 70 kDa protein
Pan265_RS05540	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Pan265_RS05560	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
Pan265_RS05565	COG0159	tryptophan synthase activity
Pan265_RS05580	COG1007	ATP synthesis coupled electron transport
Pan265_RS05585	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Pan265_RS05590	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Pan265_RS05595	COG0713	ATP synthesis coupled electron transport
Pan265_RS05600	COG0839	Belongs to the complex I subunit 6 family
Pan265_RS05610	COG1034	ATP synthesis coupled electron transport
Pan265_RS05630	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
Pan265_RS05635	COG0736	holo-[acyl-carrier-protein] synthase activity
Pan265_RS05645	COG0436	Aminotransferase
Pan265_RS05660	COG3540	Alkaline phosphatase
Pan265_RS05675	COG0077	Prephenate dehydratase
Pan265_RS05675	COG1605	Chorismate mutase
Pan265_RS05680	COG0438	transferase activity, transferring glycosyl groups
Pan265_RS05680	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Pan265_RS05695	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
Pan265_RS05695	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
Pan265_RS05710	COG0505	Belongs to the CarA family
Pan265_RS05715	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Pan265_RS05720	COG1570	exodeoxyribonuclease VII activity
Pan265_RS05725	COG1722	exodeoxyribonuclease VII activity
Pan265_RS05730	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
Pan265_RS05735	COG1360	Flagellar Motor Protein
Pan265_RS05740	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Pan265_RS05770	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Pan265_RS05775	COG1546	Belongs to the CinA family
Pan265_RS05775	COG1058	Belongs to the CinA family
Pan265_RS05780	COG4464	protein tyrosine phosphatase activity
Pan265_RS05790	COG2165	general secretion pathway protein
Pan265_RS05800	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Pan265_RS05805	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Pan265_RS05825	COG1450	Type ii and iii secretion system protein
Pan265_RS05835	COG0277	FAD linked oxidase domain protein
Pan265_RS05835	COG0247	lactate metabolic process
Pan265_RS05840	COG1619	proteins homologs of microcin C7 resistance protein MccF
Pan265_RS05855	COG0700	Nucleoside recognition
Pan265_RS05860	COG2715	membrane protein required for spore maturation
Pan265_RS05880	COG1012	belongs to the aldehyde dehydrogenase family
Pan265_RS05925	COG1609	Transcriptional regulator
Pan265_RS05930	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Pan265_RS05935	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Pan265_RS05940	COG0673	inositol 2-dehydrogenase activity
Pan265_RS05955	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Pan265_RS05955	COG0574	Belongs to the PEP-utilizing enzyme family
Pan265_RS05960	COG3119	arylsulfatase activity
Pan265_RS05965	COG1595	DNA-templated transcription, initiation
Pan265_RS05980	COG1994	Peptidase M50
Pan265_RS05985	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
Pan265_RS05995	COG1966	Carbon starvation protein
Pan265_RS06005	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
Pan265_RS06015	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Pan265_RS06025	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Pan265_RS06035	COG1657	PFAM Prenyltransferase squalene oxidase
Pan265_RS06045	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Pan265_RS06050	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Pan265_RS06060	COG2208	phosphoserine phosphatase activity
Pan265_RS06060	COG2770	Histidine kinase
Pan265_RS06075	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Pan265_RS06080	COG0367	asparagine synthase
Pan265_RS06095	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Pan265_RS06105	COG0776	regulation of translation
Pan265_RS06110	COG0156	8-amino-7-oxononanoate synthase activity
Pan265_RS06135	COG0446	pyridine nucleotide-disulphide oxidoreductase
Pan265_RS06140	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Pan265_RS06145	COG0489	protein tyrosine kinase activity
Pan265_RS06170	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Pan265_RS06185	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
Pan265_RS06210	COG3152	Membrane
Pan265_RS06235	COG2226	methyltransferase
Pan265_RS06240	COG0501	Belongs to the peptidase M48B family
Pan265_RS06255	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Pan265_RS06280	COG0133	tryptophan synthase activity
Pan265_RS06285	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Pan265_RS06290	COG0254	rRNA binding
Pan265_RS06320	COG1175	transmembrane transport
Pan265_RS06325	COG0395	ABC-type sugar transport system, permease component
Pan265_RS06350	COG0383	alpha-mannosidase activity
Pan265_RS06400	COG0523	cobalamin synthesis protein
Pan265_RS06410	COG5012	cobalamin binding
Pan265_RS06455	COG1028	Short-chain dehydrogenase reductase Sdr
Pan265_RS06460	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
Pan265_RS06460	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Pan265_RS06470	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Pan265_RS06475	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
Pan265_RS06480	COG1414	Transcriptional regulator
Pan265_RS06500	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
Pan265_RS06505	COG3250	beta-galactosidase activity
Pan265_RS06535	COG0673	inositol 2-dehydrogenase activity
Pan265_RS06545	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Pan265_RS06595	COG3119	arylsulfatase activity
Pan265_RS06600	COG3119	arylsulfatase activity
Pan265_RS06615	COG1501	Belongs to the glycosyl hydrolase 31 family
Pan265_RS06625	COG1609	Transcriptional regulator
Pan265_RS06645	COG1069	ribulokinase activity
Pan265_RS06650	COG3119	arylsulfatase activity
Pan265_RS06655	COG3119	arylsulfatase activity
Pan265_RS06685	COG0395	ABC-type sugar transport system, permease component
Pan265_RS06690	COG1175	transmembrane transport
Pan265_RS06710	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
Pan265_RS06715	COG3119	arylsulfatase activity
Pan265_RS06730	COG5434	Belongs to the glycosyl hydrolase 28 family
Pan265_RS06745	COG1609	Transcriptional regulator
Pan265_RS06755	COG3119	arylsulfatase activity
Pan265_RS06765	COG3119	arylsulfatase activity
Pan265_RS06775	COG2160	L-arabinose isomerase activity
Pan265_RS06785	COG2723	6-phospho-beta-galactosidase activity
Pan265_RS06790	COG4447	cellulose binding
Pan265_RS06805	COG1609	Transcriptional regulator
Pan265_RS06815	COG1621	beta-fructofuranosidase activity
Pan265_RS06825	COG2211	Major facilitator Superfamily
Pan265_RS06885	COG2165	general secretion pathway protein
Pan265_RS06890	COG3250	beta-galactosidase activity
Pan265_RS06900	COG4172	Belongs to the ABC transporter superfamily
Pan265_RS06905	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Pan265_RS06910	COG0747	negative chemotaxis
Pan265_RS06920	COG2963	transposase activity
Pan265_RS06925	COG2188	Transcriptional regulator
Pan265_RS06965	COG1609	Transcriptional regulator
Pan265_RS06970	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
Pan265_RS06975	COG3119	arylsulfatase activity
Pan265_RS07030	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Pan265_RS07055	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Pan265_RS07055	COG2111	Na H antiporter
Pan265_RS07060	COG2111	Na H antiporter
Pan265_RS07065	COG1006	Multisubunit Na H antiporter MnhC subunit
Pan265_RS07070	COG0651	ATP synthesis coupled electron transport
Pan265_RS07085	COG1320	monovalent cation:proton antiporter activity
Pan265_RS07090	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Pan265_RS07105	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Pan265_RS07110	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Pan265_RS07150	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Pan265_RS07160	COG1482	cell wall glycoprotein biosynthetic process
Pan265_RS07180	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Pan265_RS07195	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
Pan265_RS07210	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
Pan265_RS07220	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Pan265_RS07225	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
Pan265_RS07235	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Pan265_RS07245	COG0793	Belongs to the peptidase S41A family
Pan265_RS07250	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Pan265_RS07255	COG0321	lipoyl(octanoyl) transferase activity
Pan265_RS07255	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
Pan265_RS07265	COG0134	indole-3-glycerol-phosphate synthase activity
Pan265_RS07285	COG0681	Belongs to the peptidase S26 family
Pan265_RS07290	COG0440	acetolactate synthase activity
Pan265_RS07295	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
Pan265_RS07300	COG2205	protein histidine kinase activity
Pan265_RS07300	COG2202	Pas domain
Pan265_RS07330	COG1696	Membrane protein involved in D-alanine export
Pan265_RS07340	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Pan265_RS07360	COG0745	RESPONSE REGULATOR receiver
Pan265_RS07365	COG1560	Kdo2-lipid A biosynthetic process
Pan265_RS07380	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Pan265_RS07395	COG0072	phenylalanine-tRNA ligase activity
Pan265_RS07400	COG1758	RNA polymerase activity
Pan265_RS07405	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Pan265_RS07415	COG0436	Aminotransferase
Pan265_RS07420	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Pan265_RS07435	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
Pan265_RS07465	COG0825	malonyl-CoA metabolic process
Pan265_RS07470	COG0659	secondary active sulfate transmembrane transporter activity
Pan265_RS07485	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Pan265_RS07495	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Pan265_RS07500	COG1459	type II secretion system
Pan265_RS07540	COG0537	adenosine 5'-monophosphoramidase activity
Pan265_RS07550	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Pan265_RS07555	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Pan265_RS07560	COG0357	Ribosomal RNA small subunit methyltransferase G
Pan265_RS07565	COG0772	Belongs to the SEDS family
Pan265_RS07570	COG0768	penicillin binding
Pan265_RS07575	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Pan265_RS07615	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Pan265_RS07630	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
Pan265_RS07640	COG0438	transferase activity, transferring glycosyl groups
Pan265_RS07655	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Pan265_RS07665	COG0436	Aminotransferase
Pan265_RS07690	COG0688	phosphatidylethanolamine metabolic process
Pan265_RS07705	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Pan265_RS07720	COG0492	ferredoxin-NADP+ reductase activity
Pan265_RS07730	COG0556	nucleotide-excision repair
Pan265_RS07735	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
Pan265_RS07770	COG1012	belongs to the aldehyde dehydrogenase family
Pan265_RS07775	COG3138	arginine N-succinyltransferase
Pan265_RS07790	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Pan265_RS07820	COG0564	pseudouridine synthase activity
Pan265_RS07830	COG2096	Adenosyltransferase
Pan265_RS07835	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Pan265_RS07845	COG1469	GTP cyclohydrolase I activity
Pan265_RS07850	COG0330	HflC and HflK could
Pan265_RS07855	COG0330	HflC and HflK could
Pan265_RS07875	COG1776	CheC inhibitor of MCP methylation
Pan265_RS07875	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Pan265_RS07900	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Pan265_RS07915	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Pan265_RS07920	COG0049	tRNA binding
Pan265_RS07925	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Pan265_RS07945	COG0859	PFAM glycosyl transferase family 9
Pan265_RS07955	COG0194	GDP metabolic process
Pan265_RS07960	COG0540	Belongs to the ATCase OTCase family
Pan265_RS07975	COG2239	Acts as a magnesium transporter
Pan265_RS07985	COG0203	ribosomal protein L17
Pan265_RS07990	COG0202	RNA polymerase activity
Pan265_RS07995	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Pan265_RS08000	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Pan265_RS08005	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Pan265_RS08010	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Pan265_RS08020	COG0201	protein transport
Pan265_RS08025	COG0200	Binds to the 23S rRNA
Pan265_RS08030	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Pan265_RS08035	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Pan265_RS08040	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Pan265_RS08045	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Pan265_RS08050	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Pan265_RS08055	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Pan265_RS08065	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Pan265_RS08070	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Pan265_RS08075	COG0255	Belongs to the universal ribosomal protein uL29 family
Pan265_RS08080	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Pan265_RS08085	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Pan265_RS08100	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Pan265_RS08105	COG0089	rRNA binding
Pan265_RS08110	COG0088	Forms part of the polypeptide exit tunnel
Pan265_RS08115	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Pan265_RS08120	COG0051	transcription antitermination factor activity, RNA binding
Pan265_RS08130	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Pan265_RS08130	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Pan265_RS08135	COG0745	RESPONSE REGULATOR receiver
Pan265_RS08140	COG0142	geranyltranstransferase activity
Pan265_RS08155	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Pan265_RS08165	COG0138	bifunctional purine biosynthesis protein purh
Pan265_RS08175	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Pan265_RS08190	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Pan265_RS08220	COG1562	ergosterol biosynthetic process
Pan265_RS08230	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Pan265_RS08240	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
Pan265_RS08250	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Pan265_RS08265	COG0504	CTP synthase activity
Pan265_RS08275	COG0668	transmembrane transport
Pan265_RS08300	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
Pan265_RS08315	COG0571	ribonuclease III activity
Pan265_RS08335	COG0148	phosphopyruvate hydratase activity
Pan265_RS08345	COG1121	(ABC) transporter
Pan265_RS08355	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Pan265_RS08375	COG1199	ATP-dependent helicase activity
Pan265_RS08390	COG0222	ribosome binding
Pan265_RS08395	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Pan265_RS08400	COG0081	regulation of translation
Pan265_RS08405	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Pan265_RS08420	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Pan265_RS08430	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Pan265_RS08440	COG4956	integral membrane protein (PIN domain superfamily)
Pan265_RS08445	COG3609	addiction module antidote protein, CC2985 family
Pan265_RS08460	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Pan265_RS08465	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Pan265_RS08470	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Pan265_RS08475	COG0154	amidase activity
Pan265_RS08480	COG1940	carbohydrate kinase activity
Pan265_RS08485	COG0432	Pfam Uncharacterised protein family UPF0047
Pan265_RS08495	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Pan265_RS08505	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Pan265_RS08515	COG0166	Belongs to the GPI family
Pan265_RS08520	COG3876	Protein conserved in bacteria
Pan265_RS08540	COG0616	signal peptide processing
Pan265_RS08545	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Pan265_RS08545	COG1793	dna ligase
Pan265_RS08575	COG0786	glutamate:sodium symporter activity
Pan265_RS08585	COG2963	transposase activity
Pan265_RS08610	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Pan265_RS08650	COG1609	Transcriptional regulator
Pan265_RS08670	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Pan265_RS08725	COG0616	signal peptide processing
Pan265_RS08730	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
Pan265_RS08735	COG0501	Belongs to the peptidase M48B family
Pan265_RS08745	COG1073	alpha beta
Pan265_RS08750	COG0439	Biotin carboxylase
Pan265_RS08755	COG0511	ligase activity, forming carbon-carbon bonds
Pan265_RS08765	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Pan265_RS08775	COG2009	succinate dehydrogenase
Pan265_RS08780	COG1053	succinate dehydrogenase
Pan265_RS08785	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
Pan265_RS08790	COG3250	beta-galactosidase activity
Pan265_RS08800	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Pan265_RS08810	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Pan265_RS08815	COG0616	signal peptide processing
Pan265_RS08840	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Pan265_RS08860	COG1968	undecaprenyl-diphosphatase activity
Pan265_RS08865	COG0646	methionine synthase
Pan265_RS08865	COG1410	methionine synthase
Pan265_RS08900	COG2201	protein-glutamate methylesterase activity
Pan265_RS08905	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Pan265_RS08920	COG4864	UPF0365 protein
Pan265_RS08925	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Pan265_RS08940	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Pan265_RS08945	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Pan265_RS08955	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Pan265_RS08990	COG0135	phosphoribosylanthranilate isomerase activity
Pan265_RS08995	COG0180	Tryptophanyl-tRNA synthetase
Pan265_RS09015	COG1573	uracil-dna glycosylase
Pan265_RS09045	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Pan265_RS09050	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Pan265_RS09075	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Pan265_RS09080	COG5001	Diguanylate cyclase
Pan265_RS09080	COG3300	MHYT domain
Pan265_RS09110	COG0698	ribose 5-phosphate isomerase
Pan265_RS09120	COG0039	L-malate dehydrogenase activity
Pan265_RS09125	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
Pan265_RS09130	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Pan265_RS09135	COG0552	protein localization to endoplasmic reticulum
Pan265_RS09140	COG1490	D-aminoacyl-tRNA deacylase activity
Pan265_RS09150	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Pan265_RS09165	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Pan265_RS09170	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
Pan265_RS09175	COG0742	ribosomal rna small subunit methyltransferase
Pan265_RS09185	COG0124	histidyl-tRNA synthetase
Pan265_RS09200	COG0473	3-isopropylmalate dehydrogenase activity
Pan265_RS09205	COG1215	transferase activity, transferring glycosyl groups
Pan265_RS09215	COG0517	IMP dehydrogenase activity
Pan265_RS09220	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Pan265_RS09225	COG1692	metallophosphoesterase
Pan265_RS09235	COG0788	formyltetrahydrofolate deformylase activity
Pan265_RS09240	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Pan265_RS09265	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Pan265_RS09270	COG1054	Belongs to the UPF0176 family
Pan265_RS09295	COG1349	DNA-binding transcription factor activity
Pan265_RS09300	COG0039	L-malate dehydrogenase activity
Pan265_RS09305	COG0235	Class ii aldolase
Pan265_RS09350	COG4869	propanediol catabolic process
Pan265_RS09365	COG0673	inositol 2-dehydrogenase activity
Pan265_RS09390	COG3119	arylsulfatase activity
Pan265_RS09415	COG1653	transport
Pan265_RS09420	COG1175	transmembrane transport
Pan265_RS09425	COG0395	ABC-type sugar transport system, permease component
Pan265_RS09430	COG1472	Belongs to the glycosyl hydrolase 3 family
Pan265_RS09435	COG1609	Transcriptional regulator
Pan265_RS09450	COG3693	PFAM glycoside hydrolase, family 10
Pan265_RS09460	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
Pan265_RS09505	COG2268	Band 7 protein
Pan265_RS09520	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Pan265_RS09525	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Pan265_RS09525	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Pan265_RS09540	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Pan265_RS09550	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Pan265_RS09560	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Pan265_RS09565	COG0085	RNA polymerase activity
Pan265_RS09590	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Pan265_RS09640	COG5002	protein histidine kinase activity
Pan265_RS09650	COG1074	ATP-dependent DNA helicase activity
Pan265_RS09675	COG0339	signal peptide processing
Pan265_RS09680	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
Pan265_RS09700	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Pan265_RS09705	COG0363	glucosamine-6-phosphate deaminase activity
Pan265_RS09710	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
Pan265_RS09715	COG0445	tRNA wobble uridine modification
Pan265_RS09720	COG1013	pyruvate-flavodoxin oxidoreductase activity
Pan265_RS09725	COG0674	pyruvate-flavodoxin oxidoreductase activity
Pan265_RS09725	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Pan265_RS09730	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Pan265_RS09740	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Pan265_RS09755	COG0539	negative regulation of cytoplasmic translation
Pan265_RS09760	COG2081	HI0933 family
Pan265_RS09770	COG1136	(ABC) transporter
Pan265_RS09775	COG0714	Associated with various cellular activities
Pan265_RS09780	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
Pan265_RS09790	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Pan265_RS09805	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Pan265_RS09810	COG0237	dephospho-CoA kinase activity
Pan265_RS09815	COG0840	transmembrane signaling receptor activity
Pan265_RS09820	COG0840	transmembrane signaling receptor activity
Pan265_RS09830	COG1086	Polysaccharide biosynthesis protein
Pan265_RS09845	COG1678	Uncharacterized ACR, COG1678
Pan265_RS09880	COG0084	hydrolase, TatD family'
Pan265_RS09885	COG1331	Highly conserved protein containing a thioredoxin domain
Pan265_RS09895	COG2226	methyltransferase
Pan265_RS09905	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Pan265_RS09910	COG3608	succinylglutamate desuccinylase aspartoacylase
Pan265_RS09925	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Pan265_RS09945	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Pan265_RS09960	COG3267	Type II secretory pathway component ExeA
Pan265_RS09960	COG3409	Peptidoglycan-binding domain 1 protein
Pan265_RS09985	COG1702	phosphate starvation-inducible protein PhoH
Pan265_RS09990	COG1480	7TM receptor with intracellular HD hydrolase
Pan265_RS09995	COG0359	binds to the 23S rRNA
Pan265_RS10000	COG0629	single-stranded DNA binding
Pan265_RS10005	COG0360	Binds together with S18 to 16S ribosomal RNA
Pan265_RS10025	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Pan265_RS10070	COG0720	synthase
Pan265_RS10075	COG0602	queuosine metabolic process
Pan265_RS10080	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Pan265_RS10100	COG0175	sulfate reduction
Pan265_RS10135	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Pan265_RS10135	COG1776	CheC inhibitor of MCP methylation
Pan265_RS10150	COG1987	bacterial-type flagellum assembly
Pan265_RS10155	COG1684	flagellar biosynthetic protein fliR
Pan265_RS10160	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Pan265_RS10165	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Pan265_RS10170	COG1419	protein localization to endoplasmic reticulum
Pan265_RS10185	COG1191	sigma factor activity
Pan265_RS10190	COG0018	arginyl-trna synthetase
Pan265_RS10200	COG4786	Flagellar basal body rod
Pan265_RS10220	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
Pan265_RS10240	COG1157	protein secretion by the type III secretion system
Pan265_RS10250	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Pan265_RS10260	COG1677	Flagellar hook-basal body complex protein FliE
Pan265_RS10265	COG1558	bacterial-type flagellum-dependent cell motility
Pan265_RS10275	COG2204	response regulator
Pan265_RS10280	COG3852	Histidine kinase
Pan265_RS10295	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
Pan265_RS10300	COG1448	Aminotransferase
Pan265_RS10305	COG2165	general secretion pathway protein
Pan265_RS10310	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
Pan265_RS10325	COG0628	permease
Pan265_RS10350	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Pan265_RS10355	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Pan265_RS10360	COG0569	domain protein
Pan265_RS10370	COG0667	Aldo Keto reductase
Pan265_RS10380	COG1127	ABC transporter
Pan265_RS10390	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
Pan265_RS10405	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Pan265_RS10415	COG0358	DNA primase activity
Pan265_RS10420	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Pan265_RS10425	COG1215	transferase activity, transferring glycosyl groups
Pan265_RS10430	COG0463	Glycosyl transferase, family 2
Pan265_RS10470	COG0189	ligase activity
Pan265_RS10470	COG4067	protein conserved in archaea
Pan265_RS10475	COG0189	ligase activity
Pan265_RS10475	COG0569	domain protein
Pan265_RS10480	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Pan265_RS10485	COG1032	radical SAM domain protein
Pan265_RS10490	COG1704	LemA family
Pan265_RS10495	COG0501	Belongs to the peptidase M48B family
Pan265_RS10500	COG1070	Carbohydrate kinase
Pan265_RS10505	COG2115	Belongs to the xylose isomerase family
Pan265_RS10510	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
Pan265_RS10535	COG4166	transmembrane transport
Pan265_RS10555	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Pan265_RS10560	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Pan265_RS10565	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Pan265_RS10570	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Pan265_RS10575	COG0356	it plays a direct role in the translocation of protons across the membrane
Pan265_RS10590	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Pan265_RS10600	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Pan265_RS10685	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Pan265_RS10690	COG0528	UMP kinase activity
Pan265_RS10695	COG0233	cytoplasmic translational termination
Pan265_RS10700	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
Pan265_RS10720	COG0840	transmembrane signaling receptor activity
Pan265_RS10725	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Pan265_RS10725	COG1648	precorrin-2 dehydrogenase activity
Pan265_RS10730	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Pan265_RS10735	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Pan265_RS10745	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
Pan265_RS10750	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
Pan265_RS10755	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Pan265_RS10790	COG0653	protein targeting
Pan265_RS10800	COG0045	succinate-CoA ligase (ADP-forming) activity
Pan265_RS10820	COG0215	cysteine-tRNA ligase activity
Pan265_RS10880	COG0363	glucosamine-6-phosphate deaminase activity
Pan265_RS10895	COG3258	Cytochrome c
Pan265_RS10915	COG0509	glycine decarboxylation via glycine cleavage system
Pan265_RS10925	COG1115	amino acid carrier protein
Pan265_RS10935	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Pan265_RS10950	COG1077	Cell shape determining protein MreB Mrl
Pan265_RS10970	COG4974	Belongs to the 'phage' integrase family
Pan265_RS10990	COG1215	transferase activity, transferring glycosyl groups
Pan265_RS10995	COG0535	radical SAM domain protein
Pan265_RS11000	COG0535	radical SAM domain protein
Pan265_RS11030	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
Pan265_RS11035	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Pan265_RS11040	COG0450	alkyl hydroperoxide reductase
Pan265_RS11070	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
Pan265_RS11080	COG1216	Glycosyl transferase, family 2
Pan265_RS11085	COG0305	Participates in initiation and elongation during chromosome replication
Pan265_RS11090	COG1619	proteins homologs of microcin C7 resistance protein MccF
Pan265_RS11100	COG0495	leucyl-tRNA aminoacylation
Pan265_RS11140	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
Pan265_RS11165	COG1706	bacterial-type flagellum-dependent cell motility
Pan265_RS11170	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
Pan265_RS11180	COG4786	Flagellar basal body rod
Pan265_RS11185	COG4786	Flagellar basal body rod
Pan265_RS11190	COG3842	ATPase activity
Pan265_RS11205	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Pan265_RS11215	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Pan265_RS11220	COG0772	Belongs to the SEDS family
Pan265_RS11235	COG0482	sulfurtransferase activity
Pan265_RS11245	COG0840	transmembrane signaling receptor activity
Pan265_RS11250	COG0151	Belongs to the GarS family
Pan265_RS11260	COG0740	serine-type endopeptidase activity
Pan265_RS11270	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Pan265_RS11290	COG0714	Associated with various cellular activities
Pan265_RS11305	COG2877	3-deoxy-8-phosphooctulonate synthase activity
Pan265_RS11320	COG0590	tRNA wobble adenosine to inosine editing
Pan265_RS11325	COG0737	Belongs to the 5'-nucleotidase family
Pan265_RS11335	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
Pan265_RS11345	COG1132	(ABC) transporter
Pan265_RS11350	COG1132	(ABC) transporter
Pan265_RS11355	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Pan265_RS11360	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Pan265_RS11365	COG4172	Belongs to the ABC transporter superfamily
Pan265_RS11380	COG0228	four-way junction DNA binding
Pan265_RS11385	COG0336	Belongs to the RNA methyltransferase TrmD family
Pan265_RS11390	COG0335	large ribosomal subunit rRNA binding
Pan265_RS11395	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Pan265_RS11405	COG1136	(ABC) transporter
Pan265_RS11415	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
Pan265_RS11430	COG3119	arylsulfatase activity
Pan265_RS11440	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
Pan265_RS11445	COG1196	nuclear chromosome segregation
Pan265_RS11455	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
Pan265_RS11465	COG0758	DNA mediated transformation
Pan265_RS11470	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Pan265_RS11490	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Pan265_RS11500	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Pan265_RS11525	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Pan265_RS11525	COG3952	Lipid A Biosynthesis
Pan265_RS11530	COG0352	thiamine-phosphate diphosphorylase activity
Pan265_RS11540	COG1121	(ABC) transporter
Pan265_RS11545	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Pan265_RS11565	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Pan265_RS11575	COG2022	thiamine diphosphate biosynthetic process
Pan265_RS11580	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Pan265_RS11585	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Pan265_RS11600	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Pan265_RS11610	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Pan265_RS11625	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Pan265_RS11625	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Pan265_RS11635	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
Pan265_RS11640	COG0594	ribonuclease P activity
Pan265_RS11645	COG0038	chloride channel
Pan265_RS11655	COG0113	porphobilinogen synthase activity
Pan265_RS11660	COG4968	Prepilin-type N-terminal cleavage methylation domain
Pan265_RS11665	COG0517	IMP dehydrogenase activity
Pan265_RS11665	COG0516	GMP reductase activity
Pan265_RS11705	COG4943	cyclic-guanylate-specific phosphodiesterase activity
Pan265_RS11710	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Pan265_RS11710	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Pan265_RS11720	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
Pan265_RS11745	COG2205	protein histidine kinase activity
Pan265_RS11745	COG3437	response regulator, receiver
Pan265_RS11745	COG4999	Histidine kinase
Pan265_RS11745	COG3850	Histidine kinase
Pan265_RS11750	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
Pan265_RS11770	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Pan265_RS11775	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Pan265_RS11795	COG0174	glutamine synthetase
Pan265_RS11800	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Pan265_RS11820	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Pan265_RS11845	COG0848	biopolymer transport protein
Pan265_RS11850	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Pan265_RS11855	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Pan265_RS11855	COG0519	Catalyzes the synthesis of GMP from XMP
Pan265_RS11865	COG1653	transport
Pan265_RS11890	COG2201	protein-glutamate methylesterase activity
Pan265_RS11940	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Pan265_RS11945	COG3876	Protein conserved in bacteria
Pan265_RS11955	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
Pan265_RS11965	COG1595	DNA-templated transcription, initiation
Pan265_RS11980	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
Pan265_RS11985	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Pan265_RS11985	COG0519	Catalyzes the synthesis of GMP from XMP
Pan265_RS11990	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
Pan265_RS11995	COG1850	ribulose-bisphosphate carboxylase activity
Pan265_RS12005	COG1132	(ABC) transporter
Pan265_RS12010	COG1132	(ABC) transporter
Pan265_RS12025	COG3118	belongs to the thioredoxin family
Pan265_RS12030	COG0612	Peptidase, M16
Pan265_RS12035	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Pan265_RS12035	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Pan265_RS12045	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
Pan265_RS12050	COG0724	RNA recognition motif
Pan265_RS12055	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Pan265_RS12065	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
Pan265_RS12070	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Pan265_RS12080	COG1785	Belongs to the alkaline phosphatase family
Pan265_RS12085	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Pan265_RS12090	COG3604	Transcriptional regulator
Pan265_RS12105	COG1335	isochorismatase
Pan265_RS12130	COG3265	gluconokinase activity
Pan265_RS12140	COG1321	iron dependent repressor
Pan265_RS12145	COG0803	Belongs to the bacterial solute-binding protein 9 family
Pan265_RS12150	COG1121	(ABC) transporter
Pan265_RS12155	COG1321	iron dependent repressor
Pan265_RS12155	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Pan265_RS12160	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Pan265_RS12180	COG4106	trans-aconitate 2-methyltransferase activity
Pan265_RS12200	COG0791	NLP P60 protein
Pan265_RS12215	COG0297	glycogen (starch) synthase activity
Pan265_RS12220	COG1846	Transcriptional regulator
Pan265_RS12290	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Pan265_RS12295	COG3494	Protein of unknown function (DUF1009)
Pan265_RS12315	COG0438	transferase activity, transferring glycosyl groups
Pan265_RS12330	COG1472	Belongs to the glycosyl hydrolase 3 family
Pan265_RS12340	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Pan265_RS12355	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Pan265_RS12360	COG1543	Belongs to the glycosyl hydrolase 57 family
Pan265_RS12365	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Pan265_RS12390	COG1649	PFAM Uncharacterised BCR, COG1649
Pan265_RS12395	COG1028	Short-chain dehydrogenase reductase Sdr
Pan265_RS12400	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Pan265_RS12420	COG1381	Involved in DNA repair and RecF pathway recombination
Pan265_RS12430	COG0004	ammonium transporteR
Pan265_RS12465	COG3012	SEC-C Motif Domain Protein
Pan265_RS12470	COG1061	Type III restriction enzyme res subunit
Pan265_RS12475	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
Pan265_RS12480	COG1518	maintenance of DNA repeat elements
Pan265_RS12550	COG2801	Transposase and inactivated derivatives
Pan265_RS12555	COG3547	Transposase (IS116 IS110 IS902 family)
Pan265_RS12565	COG2211	Major facilitator Superfamily
Pan265_RS12610	COG1069	ribulokinase activity
Pan265_RS12620	COG2160	L-arabinose isomerase activity
Pan265_RS12655	COG1028	Short-chain dehydrogenase reductase Sdr
Pan265_RS12670	COG0673	inositol 2-dehydrogenase activity
Pan265_RS12700	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Pan265_RS12705	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Pan265_RS12715	COG0126	phosphoglycerate kinase activity
Pan265_RS12720	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Pan265_RS12740	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Pan265_RS12760	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
Pan265_RS12785	COG1845	cytochrome c oxidase, subunit III
Pan265_RS12800	COG1845	cytochrome c oxidase, subunit III
Pan265_RS12800	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Pan265_RS12840	COG0437	4 iron, 4 sulfur cluster binding
Pan265_RS12855	COG0792	nuclease activity
Pan265_RS12860	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Pan265_RS12865	COG1595	DNA-templated transcription, initiation
Pan265_RS12885	COG0019	diaminopimelate decarboxylase activity
Pan265_RS12890	COG1104	cysteine desulfurase activity
Pan265_RS12905	COG4221	oxidoreductase activity
Pan265_RS12910	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Pan265_RS12920	COG2255	four-way junction helicase activity
Pan265_RS12940	COG1999	signal sequence binding
Pan265_RS12955	COG0740	serine-type endopeptidase activity
Pan265_RS12990	COG0297	glycogen (starch) synthase activity
Pan265_RS12995	COG0438	transferase activity, transferring glycosyl groups
Pan265_RS13000	COG0110	maltose O-acetyltransferase activity
Pan265_RS13010	COG0347	Belongs to the P(II) protein family
Pan265_RS13015	COG0004	ammonium transporteR
Pan265_RS13030	COG0438	transferase activity, transferring glycosyl groups
Pan265_RS13055	COG0590	tRNA wobble adenosine to inosine editing
Pan265_RS13060	COG1192	Involved in chromosome partitioning
Pan265_RS13065	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Pan265_RS13080	COG0659	secondary active sulfate transmembrane transporter activity
Pan265_RS13095	COG2001	Belongs to the MraZ family
Pan265_RS13100	COG3852	Histidine kinase
Pan265_RS13110	COG2201	protein-glutamate methylesterase activity
Pan265_RS13120	COG0745	RESPONSE REGULATOR receiver
Pan265_RS13130	COG0643	Histidine kinase
Pan265_RS13130	COG2198	Histidine kinase
Pan265_RS13130	COG0784	Response regulator, receiver
Pan265_RS13135	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Pan265_RS13140	COG0835	chemotaxis
Pan265_RS13150	COG0009	L-threonylcarbamoyladenylate synthase
Pan265_RS13180	COG1131	(ABC) transporter
Pan265_RS13210	COG0676	glucose-6-phosphate 1-epimerase activity
Pan265_RS13215	COG1301	dicarboxylic acid transport
Pan265_RS13220	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
Pan265_RS13245	COG1136	(ABC) transporter
Pan265_RS13265	COG1942	4-Oxalocrotonate Tautomerase
Pan265_RS13315	COG0668	transmembrane transport
Pan265_RS13320	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Pan265_RS13325	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Pan265_RS13330	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Pan265_RS13345	COG4166	transmembrane transport
Pan265_RS13350	COG0601	transmembrane transport
Pan265_RS13355	COG0346	lactoylglutathione lyase activity
Pan265_RS13370	COG0511	ligase activity, forming carbon-carbon bonds
Pan265_RS13375	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
Pan265_RS13380	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
Pan265_RS13380	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
Pan265_RS13385	COG0427	acetyl-CoA hydrolase
Pan265_RS13390	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Pan265_RS13400	COG0557	exoribonuclease II activity
Pan265_RS13480	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Pan265_RS13495	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Pan265_RS13505	COG1012	belongs to the aldehyde dehydrogenase family
Pan265_RS13510	COG3240	lipase activity
Pan265_RS13520	COG0840	transmembrane signaling receptor activity
Pan265_RS13540	COG0840	transmembrane signaling receptor activity
Pan265_RS13575	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
Pan265_RS13580	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Pan265_RS13605	COG0205	6-phosphofructokinase activity
Pan265_RS13610	COG1796	DNA polymerase
Pan265_RS13610	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Pan265_RS13615	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Pan265_RS13615	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Pan265_RS13625	COG2337	Toxic component of a toxin-antitoxin (TA) module
Pan265_RS13645	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Pan265_RS13665	COG1030	water channel activity
Pan265_RS13670	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Pan265_RS13670	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Pan265_RS13685	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
Pan265_RS13700	COG1703	isobutyryl-CoA mutase activity
Pan265_RS13730	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Pan265_RS13735	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Pan265_RS13740	COG0714	Associated with various cellular activities
Pan265_RS13780	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
Pan265_RS13800	COG0633	Ferredoxin
Pan265_RS13805	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
Pan265_RS13835	COG3481	metal-dependent phosphohydrolase, HD sub domain
Pan265_RS13845	COG0318	PFAM AMP-dependent synthetase and ligase
Pan265_RS13855	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Pan265_RS13860	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Pan265_RS13865	COG0022	dehydrogenase e1 component
Pan265_RS13865	COG0508	dehydrogenase complex catalyzes the overall conversion of
Pan265_RS13870	COG0508	dehydrogenase complex catalyzes the overall conversion of
Pan265_RS13880	COG0613	PHP domain protein
Pan265_RS13900	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Pan265_RS13905	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Pan265_RS13910	COG2835	tetraacyldisaccharide 4'-kinase activity
Pan265_RS13975	COG1083	cytidylyl-transferase
Pan265_RS13975	COG2755	lipolytic protein G-D-S-L family
Pan265_RS13980	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
Pan265_RS13990	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Pan265_RS14000	COG0493	'glutamate synthase
Pan265_RS14005	COG0067	glutamate synthase
Pan265_RS14005	COG0069	glutamate synthase activity
Pan265_RS14005	COG0070	glutamate synthase
Pan265_RS14015	COG0297	glycogen (starch) synthase activity
Pan265_RS14040	COG0542	response to heat
Pan265_RS14055	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Pan265_RS14070	COG0220	tRNA (guanine-N7-)-methyltransferase activity
Pan265_RS14090	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Pan265_RS14095	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
Pan265_RS14140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Pan265_RS14175	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
Pan265_RS14195	COG0523	cobalamin synthesis protein
Pan265_RS14225	COG1181	Belongs to the D-alanine--D-alanine ligase family
Pan265_RS14240	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Pan265_RS14255	COG1254	Belongs to the acylphosphatase family
Pan265_RS14260	COG0793	Belongs to the peptidase S41A family
Pan265_RS14265	COG0217	transcriptional regulatory protein
Pan265_RS14305	COG0443	Heat shock 70 kDa protein
Pan265_RS14315	COG1045	serine acetyltransferase
Pan265_RS14340	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Pan265_RS14360	COG1609	Transcriptional regulator
Pan265_RS14375	COG0860	N-Acetylmuramoyl-L-alanine amidase
Pan265_RS14375	COG2247	cell wall binding repeat
Pan265_RS14405	COG1649	PFAM Uncharacterised BCR, COG1649
Pan265_RS14430	COG0316	Belongs to the HesB IscA family
Pan265_RS14450	COG0563	adenylate kinase activity
Pan265_RS14465	COG0612	Peptidase, M16
Pan265_RS14495	COG1487	ribonuclease activity
Pan265_RS14505	COG1160	GTP binding
Pan265_RS14510	COG1214	PFAM Peptidase M22, glycoprotease
Pan265_RS14515	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Pan265_RS14540	COG1051	belongs to the nudix hydrolase family
Pan265_RS14560	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
Pan265_RS14570	COG2890	protein-(glutamine-N5) methyltransferase activity