locus-tag	class	description
Spb1_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Spb1_RS00010	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
Spb1_RS00020	COG0131	Imidazoleglycerol-phosphate dehydratase
Spb1_RS00025	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Spb1_RS00040	COG1556	Lactate utilization protein
Spb1_RS00045	COG0483	inositol monophosphate 1-phosphatase activity
Spb1_RS00050	COG3119	arylsulfatase activity
Spb1_RS00055	COG1070	Carbohydrate kinase
Spb1_RS00060	COG0367	asparagine synthase
Spb1_RS00070	COG0579	oxidoreductase
Spb1_RS00095	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
Spb1_RS00115	COG1136	(ABC) transporter
Spb1_RS00120	COG0640	Transcriptional regulator
Spb1_RS00130	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Spb1_RS00135	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Spb1_RS00150	COG0673	inositol 2-dehydrogenase activity
Spb1_RS00170	COG0515	serine threonine protein kinase
Spb1_RS00170	COG2815	serine threonine protein kinase
Spb1_RS00180	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Spb1_RS00190	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Spb1_RS00200	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Spb1_RS00225	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Spb1_RS00225	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Spb1_RS00235	COG0017	Asparaginyl-tRNA synthetase
Spb1_RS00240	COG0481	GTPase activity
Spb1_RS00250	COG3119	arylsulfatase activity
Spb1_RS00265	COG3409	Peptidoglycan-binding domain 1 protein
Spb1_RS00265	COG0793	Belongs to the peptidase S41A family
Spb1_RS00275	COG5487	UPF0391 membrane protein
Spb1_RS00285	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Spb1_RS00330	COG2189	Belongs to the N(4) N(6)-methyltransferase family
Spb1_RS00335	COG0539	negative regulation of cytoplasmic translation
Spb1_RS00395	COG2442	InterPro IPR007367
Spb1_RS00400	COG0673	inositol 2-dehydrogenase activity
Spb1_RS00405	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Spb1_RS00410	COG0516	GMP reductase activity
Spb1_RS00410	COG0517	IMP dehydrogenase activity
Spb1_RS00425	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
Spb1_RS00430	COG0463	Glycosyl transferase, family 2
Spb1_RS00465	COG0508	dehydrogenase complex catalyzes the overall conversion of
Spb1_RS00480	COG0436	Aminotransferase
Spb1_RS00545	COG4178	(ABC) transporter
Spb1_RS00570	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Spb1_RS00575	COG1058	Belongs to the CinA family
Spb1_RS00575	COG1546	Belongs to the CinA family
Spb1_RS00585	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Spb1_RS00590	COG0247	lactate metabolic process
Spb1_RS00595	COG1139	Iron-sulfur cluster binding protein
Spb1_RS00605	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Spb1_RS00630	COG0084	hydrolase, TatD family'
Spb1_RS00635	COG2022	thiamine diphosphate biosynthetic process
Spb1_RS00640	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Spb1_RS00655	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Spb1_RS00760	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Spb1_RS00770	COG0515	serine threonine protein kinase
Spb1_RS00770	COG2815	serine threonine protein kinase
Spb1_RS00800	COG3119	arylsulfatase activity
Spb1_RS00805	COG1136	(ABC) transporter
Spb1_RS00825	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Spb1_RS00860	COG0494	nUDIX hydrolase
Spb1_RS00870	COG0247	lactate metabolic process
Spb1_RS00880	COG0123	including yeast histone deacetylase and acetoin utilization protein
Spb1_RS00910	COG2353	YceI-like domain
Spb1_RS00935	COG0347	Belongs to the P(II) protein family
Spb1_RS00960	COG1082	Xylose isomerase domain protein TIM barrel
Spb1_RS01010	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
Spb1_RS01020	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Spb1_RS01045	COG0745	RESPONSE REGULATOR receiver
Spb1_RS01075	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Spb1_RS01085	COG0495	leucyl-tRNA aminoacylation
Spb1_RS01120	COG0517	IMP dehydrogenase activity
Spb1_RS01120	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
Spb1_RS01150	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
Spb1_RS01155	COG0545	Peptidyl-prolyl cis-trans isomerase
Spb1_RS01160	COG0339	signal peptide processing
Spb1_RS01165	COG1450	Type ii and iii secretion system protein
Spb1_RS01175	COG1253	flavin adenine dinucleotide binding
Spb1_RS01195	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Spb1_RS01200	COG2706	6-phosphogluconolactonase activity
Spb1_RS01210	COG1012	belongs to the aldehyde dehydrogenase family
Spb1_RS01225	COG1234	tRNA 3'-trailer cleavage
Spb1_RS01245	COG0714	Associated with various cellular activities
Spb1_RS01270	COG0584	glycerophosphoryl diester phosphodiesterase
Spb1_RS01290	COG3119	arylsulfatase activity
Spb1_RS01300	COG0577	efflux transmembrane transporter activity
Spb1_RS01305	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Spb1_RS01310	COG2258	MOSC domain
Spb1_RS01325	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Spb1_RS01330	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Spb1_RS01350	COG0473	3-isopropylmalate dehydrogenase activity
Spb1_RS01355	COG2234	aminopeptidase activity
Spb1_RS01360	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Spb1_RS01365	COG0515	serine threonine protein kinase
Spb1_RS01365	COG2815	serine threonine protein kinase
Spb1_RS01380	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
Spb1_RS01420	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Spb1_RS01425	COG4191	Histidine kinase
Spb1_RS01450	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Spb1_RS01455	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
Spb1_RS01460	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Spb1_RS01465	COG0237	dephospho-CoA kinase activity
Spb1_RS01470	COG0318	PFAM AMP-dependent synthetase and ligase
Spb1_RS01490	COG4964	Belongs to the GSP D family
Spb1_RS01515	COG1956	GAF domain-containing protein
Spb1_RS01530	COG0165	Argininosuccinate lyase
Spb1_RS01550	COG2205	protein histidine kinase activity
Spb1_RS01555	COG0745	RESPONSE REGULATOR receiver
Spb1_RS01565	COG0673	inositol 2-dehydrogenase activity
Spb1_RS01570	COG0673	inositol 2-dehydrogenase activity
Spb1_RS01595	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Spb1_RS01595	COG1017	nitric oxide dioxygenase activity
Spb1_RS01600	COG1959	2 iron, 2 sulfur cluster binding
Spb1_RS01625	COG0811	peptide transport
Spb1_RS01640	COG0686	Belongs to the AlaDH PNT family
Spb1_RS01655	COG3118	belongs to the thioredoxin family
Spb1_RS01655	COG0492	ferredoxin-NADP+ reductase activity
Spb1_RS01660	COG2195	Cleaves the N-terminal amino acid of tripeptides
Spb1_RS01665	COG2721	sulfolactate sulfo-lyase activity
Spb1_RS01690	COG1104	cysteine desulfurase activity
Spb1_RS01705	COG3253	May function as heme-dependent peroxidase
Spb1_RS01710	COG1166	arginine decarboxylase activity
Spb1_RS01715	COG4864	UPF0365 protein
Spb1_RS01730	COG1595	DNA-templated transcription, initiation
Spb1_RS01750	COG3119	arylsulfatase activity
Spb1_RS01790	COG1216	Glycosyl transferase, family 2
Spb1_RS01800	COG1858	cytochrome C peroxidase
Spb1_RS01805	COG0129	dihydroxy-acid dehydratase activity
Spb1_RS01810	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
Spb1_RS01815	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
Spb1_RS01835	COG0673	inositol 2-dehydrogenase activity
Spb1_RS01840	COG2197	response regulator
Spb1_RS01885	COG3046	protein related to deoxyribodipyrimidine photolyase
Spb1_RS01890	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Spb1_RS01915	COG1131	(ABC) transporter
Spb1_RS01920	COG0659	secondary active sulfate transmembrane transporter activity
Spb1_RS01925	COG2096	Adenosyltransferase
Spb1_RS01930	COG2207	Transcriptional regulator
Spb1_RS01930	COG1609	Transcriptional regulator
Spb1_RS01975	COG0726	polysaccharide deacetylase
Spb1_RS01980	COG0297	glycogen (starch) synthase activity
Spb1_RS01980	COG0438	transferase activity, transferring glycosyl groups
Spb1_RS01990	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
Spb1_RS02010	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Spb1_RS02055	COG0443	Heat shock 70 kDa protein
Spb1_RS02080	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
Spb1_RS02085	COG0047	phosphoribosylformylglycinamidine synthase activity
Spb1_RS02090	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Spb1_RS02095	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Spb1_RS02100	COG0649	NAD binding
Spb1_RS02100	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Spb1_RS02105	COG0649	NAD binding
Spb1_RS02125	COG1034	ATP synthesis coupled electron transport
Spb1_RS02130	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Spb1_RS02135	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Spb1_RS02140	COG0839	Belongs to the complex I subunit 6 family
Spb1_RS02145	COG0713	ATP synthesis coupled electron transport
Spb1_RS02185	COG1506	peptidase
Spb1_RS02185	COG0823	Involved in the tonB-independent uptake of proteins
Spb1_RS02190	COG3119	arylsulfatase activity
Spb1_RS02230	COG0673	inositol 2-dehydrogenase activity
Spb1_RS02245	COG3386	PFAM SMP-30 Gluconolaconase
Spb1_RS02255	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Spb1_RS02260	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
Spb1_RS02325	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Spb1_RS02330	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Spb1_RS02350	COG3119	arylsulfatase activity
Spb1_RS02380	COG1558	bacterial-type flagellum-dependent cell motility
Spb1_RS02385	COG1677	Flagellar hook-basal body complex protein FliE
Spb1_RS02440	COG1028	Short-chain dehydrogenase reductase Sdr
Spb1_RS02475	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
Spb1_RS02480	COG2890	protein-(glutamine-N5) methyltransferase activity
Spb1_RS02485	COG1385	rRNA (uridine-N3-)-methyltransferase activity
Spb1_RS02525	COG0437	4 iron, 4 sulfur cluster binding
Spb1_RS02560	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Spb1_RS02560	COG1845	cytochrome c oxidase, subunit III
Spb1_RS02565	COG1845	cytochrome c oxidase, subunit III
Spb1_RS02575	COG1845	cytochrome c oxidase, subunit III
Spb1_RS02580	COG0166	Belongs to the GPI family
Spb1_RS02585	COG0436	Aminotransferase
Spb1_RS02590	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
Spb1_RS02595	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Spb1_RS02605	COG3119	arylsulfatase activity
Spb1_RS02610	COG0515	serine threonine protein kinase
Spb1_RS02610	COG2815	serine threonine protein kinase
Spb1_RS02620	COG2226	methyltransferase
Spb1_RS02630	COG3842	ATPase activity
Spb1_RS02655	COG0673	inositol 2-dehydrogenase activity
Spb1_RS02660	COG0714	Associated with various cellular activities
Spb1_RS02670	COG1063	alcohol dehydrogenase
Spb1_RS02690	COG0275	rRNA processing
Spb1_RS02725	COG0482	sulfurtransferase activity
Spb1_RS02735	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Spb1_RS02745	COG0135	phosphoribosylanthranilate isomerase activity
Spb1_RS02770	COG1132	(ABC) transporter
Spb1_RS02795	COG2815	serine threonine protein kinase
Spb1_RS02795	COG0515	serine threonine protein kinase
Spb1_RS02850	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Spb1_RS02870	COG1987	bacterial-type flagellum assembly
Spb1_RS02875	COG1338	Plays a role in the flagellum-specific transport system
Spb1_RS02885	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Spb1_RS02885	COG1776	CheC inhibitor of MCP methylation
Spb1_RS02915	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Spb1_RS02945	COG1253	flavin adenine dinucleotide binding
Spb1_RS02950	COG2226	methyltransferase
Spb1_RS02955	COG0655	NAD(P)H dehydrogenase (quinone) activity
Spb1_RS02960	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Spb1_RS02965	COG1595	DNA-templated transcription, initiation
Spb1_RS03005	COG0277	FAD linked oxidase domain protein
Spb1_RS03030	COG2738	Putative neutral zinc metallopeptidase
Spb1_RS03035	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
Spb1_RS03070	COG0322	excinuclease ABC activity
Spb1_RS03095	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Spb1_RS03155	COG1160	GTP binding
Spb1_RS03160	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Spb1_RS03165	COG0328	RNA-DNA hybrid ribonuclease activity
Spb1_RS03190	COG1187	pseudouridine synthase activity
Spb1_RS03195	COG0543	2 iron, 2 sulfur cluster binding
Spb1_RS03200	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Spb1_RS03205	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Spb1_RS03230	COG0116	Belongs to the methyltransferase superfamily
Spb1_RS03260	COG5609	conserved protein (DUF2294)
Spb1_RS03265	COG0438	transferase activity, transferring glycosyl groups
Spb1_RS03270	COG0137	argininosuccinate synthase activity
Spb1_RS03300	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Spb1_RS03305	COG0552	protein localization to endoplasmic reticulum
Spb1_RS03370	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
Spb1_RS03375	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
Spb1_RS03380	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Spb1_RS03390	COG0598	Magnesium transport protein CorA
Spb1_RS03395	COG1597	lipid kinase activity
Spb1_RS03400	COG2877	3-deoxy-8-phosphooctulonate synthase activity
Spb1_RS03410	COG1012	belongs to the aldehyde dehydrogenase family
Spb1_RS03440	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Spb1_RS03465	COG0758	DNA mediated transformation
Spb1_RS03475	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Spb1_RS03515	COG3011	Protein conserved in bacteria
Spb1_RS03525	COG0673	inositol 2-dehydrogenase activity
Spb1_RS03540	COG4285	Biotin-protein ligase, N terminal
Spb1_RS03560	COG0124	histidyl-tRNA synthetase
Spb1_RS03570	COG1333	cytochrome c biogenesis protein
Spb1_RS03570	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Spb1_RS03600	COG4191	Histidine kinase
Spb1_RS03605	COG1078	dGTPase activity
Spb1_RS03610	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
Spb1_RS03620	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Spb1_RS03625	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Spb1_RS03635	COG1181	Belongs to the D-alanine--D-alanine ligase family
Spb1_RS03640	COG0673	inositol 2-dehydrogenase activity
Spb1_RS03655	COG2205	protein histidine kinase activity
Spb1_RS03660	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Spb1_RS03700	COG2154	pterin-4-alpha-carbinolamine dehydratase
Spb1_RS03715	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Spb1_RS03790	COG2022	thiamine diphosphate biosynthetic process
Spb1_RS03790	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Spb1_RS03810	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Spb1_RS03840	COG0742	ribosomal rna small subunit methyltransferase
Spb1_RS03860	COG1691	(AIR) carboxylase
Spb1_RS03870	COG0439	Biotin carboxylase
Spb1_RS03875	COG0511	ligase activity, forming carbon-carbon bonds
Spb1_RS03880	COG0006	proline dipeptidase activity
Spb1_RS03885	COG2409	Drug exporters of the RND superfamily
Spb1_RS03890	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Spb1_RS03900	COG0471	metal ion transport
Spb1_RS03905	COG1131	(ABC) transporter
Spb1_RS03945	COG0538	isocitrate dehydrogenase activity
Spb1_RS03950	COG1774	PSP1 C-terminal conserved region
Spb1_RS03955	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Spb1_RS03960	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Spb1_RS04005	COG1538	Outer membrane efflux protein
Spb1_RS04010	COG4251	negative regulation of phosphorylation
Spb1_RS04010	COG5001	Diguanylate cyclase
Spb1_RS04010	COG3706	GGDEF domain
Spb1_RS04010	COG2203	Gaf domain
Spb1_RS04015	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Spb1_RS04035	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
Spb1_RS04050	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
Spb1_RS04055	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
Spb1_RS04070	COG0187	DNA topoisomerase II activity
Spb1_RS04075	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Spb1_RS04115	COG1760	l-serine dehydratase
Spb1_RS04145	COG1376	ErfK ybiS ycfS ynhG family protein
Spb1_RS04165	COG1136	(ABC) transporter
Spb1_RS04165	COG0577	efflux transmembrane transporter activity
Spb1_RS04190	COG0315	cyclic pyranopterin monophosphate synthase activity
Spb1_RS04200	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
Spb1_RS04220	COG2204	response regulator
Spb1_RS04225	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Spb1_RS04235	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Spb1_RS04255	COG1966	Carbon starvation protein
Spb1_RS04260	COG0142	geranyltranstransferase activity
Spb1_RS04265	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Spb1_RS04265	COG1793	dna ligase
Spb1_RS04285	COG1459	type II secretion system
Spb1_RS04290	COG1011	Hydrolase
Spb1_RS04295	COG1663	tetraacyldisaccharide 4'-kinase activity
Spb1_RS04315	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Spb1_RS04315	COG0519	Catalyzes the synthesis of GMP from XMP
Spb1_RS04325	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Spb1_RS04345	COG0356	it plays a direct role in the translocation of protons across the membrane
Spb1_RS04350	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Spb1_RS04360	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Spb1_RS04365	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Spb1_RS04370	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Spb1_RS04375	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Spb1_RS04380	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Spb1_RS04385	COG0335	large ribosomal subunit rRNA binding
Spb1_RS04390	COG0336	Belongs to the RNA methyltransferase TrmD family
Spb1_RS04395	COG0228	four-way junction DNA binding
Spb1_RS04400	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Spb1_RS04430	COG1199	ATP-dependent helicase activity
Spb1_RS04445	COG0788	formyltetrahydrofolate deformylase activity
Spb1_RS04465	COG0728	peptidoglycan biosynthetic process
Spb1_RS04475	COG2204	response regulator
Spb1_RS04480	COG0424	maF-like protein
Spb1_RS04495	COG1573	uracil-dna glycosylase
Spb1_RS04510	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Spb1_RS04515	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Spb1_RS04545	COG0358	DNA primase activity
Spb1_RS04545	COG0305	Participates in initiation and elongation during chromosome replication
Spb1_RS04550	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Spb1_RS04560	COG2322	membrane
Spb1_RS04600	COG0515	serine threonine protein kinase
Spb1_RS04620	COG0571	ribonuclease III activity
Spb1_RS04650	COG3852	Histidine kinase
Spb1_RS04655	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Spb1_RS04665	COG0612	Peptidase, M16
Spb1_RS04675	COG3118	belongs to the thioredoxin family
Spb1_RS04690	COG0242	peptide deformylase activity
Spb1_RS04720	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Spb1_RS04760	COG1846	Transcriptional regulator
Spb1_RS04775	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Spb1_RS04780	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Spb1_RS04785	COG0839	Belongs to the complex I subunit 6 family
Spb1_RS04790	COG0713	ATP synthesis coupled electron transport
Spb1_RS04800	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Spb1_RS04805	COG1007	ATP synthesis coupled electron transport
Spb1_RS04830	COG0628	permease
Spb1_RS04840	COG2848	UPF0210 protein
Spb1_RS04875	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
Spb1_RS04885	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Spb1_RS04955	COG0330	HflC and HflK could
Spb1_RS05040	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Spb1_RS05055	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
Spb1_RS05070	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
Spb1_RS05075	COG0529	Catalyzes the synthesis of activated sulfate
Spb1_RS05085	COG1595	DNA-templated transcription, initiation
Spb1_RS05100	COG2814	Major facilitator Superfamily
Spb1_RS05105	COG0066	3-isopropylmalate dehydratase activity
Spb1_RS05115	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Spb1_RS05135	COG2363	Small membrane protein
Spb1_RS05150	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
Spb1_RS05150	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
Spb1_RS05155	COG0006	proline dipeptidase activity
Spb1_RS05165	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Spb1_RS05180	COG0454	-acetyltransferase
Spb1_RS05180	COG0456	acetyltransferase
Spb1_RS05185	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Spb1_RS05190	COG3959	Transketolase, thiamine diphosphate binding domain
Spb1_RS05200	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
Spb1_RS05220	COG1943	Transposase
Spb1_RS05230	COG3119	arylsulfatase activity
Spb1_RS05240	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Spb1_RS05245	COG1530	ribonuclease E activity
Spb1_RS05255	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Spb1_RS05260	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Spb1_RS05270	COG2133	pyrroloquinoline quinone binding
Spb1_RS05295	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Spb1_RS05300	COG0175	sulfate reduction
Spb1_RS05325	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Spb1_RS05335	COG1185	polyribonucleotide nucleotidyltransferase activity
Spb1_RS05340	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Spb1_RS05345	COG0165	Argininosuccinate lyase
Spb1_RS05345	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
Spb1_RS05350	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
Spb1_RS05385	COG0489	protein tyrosine kinase activity
Spb1_RS05450	COG1459	type II secretion system
Spb1_RS05455	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Spb1_RS05465	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Spb1_RS05525	COG1459	type II secretion system
Spb1_RS05530	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Spb1_RS05545	COG5002	protein histidine kinase activity
Spb1_RS05550	COG1570	exodeoxyribonuclease VII activity
Spb1_RS05565	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
Spb1_RS05600	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Spb1_RS05630	COG0081	regulation of translation
Spb1_RS05640	COG0222	ribosome binding
Spb1_RS05645	COG0085	RNA polymerase activity
Spb1_RS05655	COG0463	Glycosyl transferase, family 2
Spb1_RS05660	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Spb1_RS05675	COG0187	DNA topoisomerase II activity
Spb1_RS05680	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Spb1_RS05690	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
Spb1_RS05720	COG0784	Response regulator, receiver
Spb1_RS05735	COG0604	alcohol dehydrogenase
Spb1_RS05735	COG3321	synthase
Spb1_RS05740	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Spb1_RS05740	COG2070	2-Nitropropane dioxygenase
Spb1_RS05775	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Spb1_RS05780	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Spb1_RS05785	COG0049	tRNA binding
Spb1_RS05790	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Spb1_RS05795	COG0051	transcription antitermination factor activity, RNA binding
Spb1_RS05800	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Spb1_RS05805	COG0088	Forms part of the polypeptide exit tunnel
Spb1_RS05810	COG0089	rRNA binding
Spb1_RS05815	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Spb1_RS05820	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Spb1_RS05825	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Spb1_RS05830	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Spb1_RS05835	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Spb1_RS05840	COG0255	Belongs to the universal ribosomal protein uL29 family
Spb1_RS05845	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Spb1_RS05850	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Spb1_RS05855	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Spb1_RS05860	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Spb1_RS05865	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Spb1_RS05870	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Spb1_RS05875	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Spb1_RS05880	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Spb1_RS05885	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Spb1_RS05890	COG0200	Binds to the 23S rRNA
Spb1_RS05905	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Spb1_RS05910	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Spb1_RS05915	COG0202	RNA polymerase activity
Spb1_RS05920	COG0203	ribosomal protein L17
Spb1_RS06005	COG1917	Cupin 2, conserved barrel domain protein
Spb1_RS06005	COG4977	sequence-specific DNA binding
Spb1_RS06020	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Spb1_RS06125	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
Spb1_RS06130	COG0667	Aldo Keto reductase
Spb1_RS06145	COG1162	GTPase activity
Spb1_RS06160	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
Spb1_RS06160	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
Spb1_RS06205	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Spb1_RS06225	COG4221	oxidoreductase activity
Spb1_RS06225	COG0604	alcohol dehydrogenase
Spb1_RS06225	COG3321	synthase
Spb1_RS06225	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
Spb1_RS06250	COG3119	arylsulfatase activity
Spb1_RS06280	COG1063	alcohol dehydrogenase
Spb1_RS06310	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Spb1_RS06325	COG1505	serine-type exopeptidase activity
Spb1_RS06350	COG3706	GGDEF domain
Spb1_RS06380	COG1454	alcohol dehydrogenase
Spb1_RS06390	COG0202	RNA polymerase activity
Spb1_RS06400	COG0542	response to heat
Spb1_RS06405	COG0352	thiamine-phosphate diphosphorylase activity
Spb1_RS06445	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Spb1_RS06450	COG0626	cystathionine gamma-synthase activity
Spb1_RS06460	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Spb1_RS06470	COG0714	Associated with various cellular activities
Spb1_RS06500	COG0508	dehydrogenase complex catalyzes the overall conversion of
Spb1_RS06520	COG0443	Heat shock 70 kDa protein
Spb1_RS06535	COG1741	Belongs to the pirin family
Spb1_RS06540	COG2259	Doxx family
Spb1_RS06545	COG0564	pseudouridine synthase activity
Spb1_RS06555	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Spb1_RS06575	COG0438	transferase activity, transferring glycosyl groups
Spb1_RS06595	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Spb1_RS06630	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Spb1_RS06640	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
Spb1_RS06645	COG3119	arylsulfatase activity
Spb1_RS06675	COG0463	Glycosyl transferase, family 2
Spb1_RS06685	COG0793	Belongs to the peptidase S41A family
Spb1_RS06690	COG0484	heat shock protein binding
Spb1_RS06735	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
Spb1_RS06740	COG5285	phytanoyl-CoA dioxygenase
Spb1_RS06745	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
Spb1_RS06745	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Spb1_RS06765	COG0004	ammonium transporteR
Spb1_RS06770	COG0004	ammonium transporteR
Spb1_RS06775	COG0004	ammonium transporteR
Spb1_RS06780	COG0004	ammonium transporteR
Spb1_RS06795	COG3437	response regulator, receiver
Spb1_RS06800	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Spb1_RS06805	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Spb1_RS06815	COG0174	glutamine synthetase
Spb1_RS06835	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
Spb1_RS06840	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Spb1_RS06850	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Spb1_RS06860	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Spb1_RS06865	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
Spb1_RS06885	COG1404	Belongs to the peptidase S8 family
Spb1_RS06930	COG3507	Belongs to the glycosyl hydrolase 43 family
Spb1_RS06930	COG2382	esterase
Spb1_RS06930	COG3693	PFAM glycoside hydrolase, family 10
Spb1_RS06945	COG3132	Protein of unknown function, DUF480
Spb1_RS06955	COG3119	arylsulfatase activity
Spb1_RS06985	COG1070	Carbohydrate kinase
Spb1_RS07000	COG1381	Involved in DNA repair and RecF pathway recombination
Spb1_RS07040	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
Spb1_RS07050	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Spb1_RS07055	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Spb1_RS07055	COG0515	serine threonine protein kinase
Spb1_RS07085	COG0438	transferase activity, transferring glycosyl groups
Spb1_RS07095	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
Spb1_RS07095	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
Spb1_RS07110	COG0372	Belongs to the citrate synthase family
Spb1_RS07115	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Spb1_RS07120	COG2943	transferase activity, transferring hexosyl groups
Spb1_RS07135	COG3961	Belongs to the TPP enzyme family
Spb1_RS07155	COG1028	Short-chain dehydrogenase reductase Sdr
Spb1_RS07180	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Spb1_RS07185	COG0546	phosphoglycolate phosphatase activity
Spb1_RS07195	COG2267	carboxylic ester hydrolase activity
Spb1_RS07205	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
Spb1_RS07220	COG0314	molybdopterin synthase activity
Spb1_RS07225	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Spb1_RS07230	COG2234	aminopeptidase activity
Spb1_RS07245	COG4864	UPF0365 protein
Spb1_RS07255	COG0268	Binds directly to 16S ribosomal RNA
Spb1_RS07270	COG0114	fumarate hydratase activity
Spb1_RS07280	COG0828	Belongs to the bacterial ribosomal protein bS21 family
Spb1_RS07300	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Spb1_RS07310	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Spb1_RS07315	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Spb1_RS07320	COG0101	tRNA pseudouridine synthase activity
Spb1_RS07340	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Spb1_RS07405	COG2815	serine threonine protein kinase
Spb1_RS07405	COG0515	serine threonine protein kinase
Spb1_RS07420	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
Spb1_RS07425	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
Spb1_RS07435	COG0802	atpase or kinase
Spb1_RS07440	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
Spb1_RS07455	COG1858	cytochrome C peroxidase
Spb1_RS07495	COG0667	Aldo Keto reductase
Spb1_RS07535	COG0745	RESPONSE REGULATOR receiver
Spb1_RS07540	COG3030	protein affecting phage T7 exclusion by the F plasmid
Spb1_RS07565	COG3119	arylsulfatase activity
Spb1_RS07580	COG2866	Carboxypeptidase
Spb1_RS07590	COG1172	Belongs to the binding-protein-dependent transport system permease family
Spb1_RS07595	COG1129	ABC transporter
Spb1_RS07600	COG1879	ABC-type sugar transport system periplasmic component
Spb1_RS07625	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
Spb1_RS07630	COG0167	dihydroorotate dehydrogenase activity
Spb1_RS07635	COG0180	Tryptophanyl-tRNA synthetase
Spb1_RS07650	COG4555	ABC transporter
Spb1_RS07655	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
Spb1_RS07670	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Spb1_RS07675	COG3869	Catalyzes the specific phosphorylation of arginine residues in
Spb1_RS07680	COG3880	PFAM UvrB UvrC protein
Spb1_RS07695	COG1940	carbohydrate kinase activity
Spb1_RS07720	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Spb1_RS07740	COG0302	gtp cyclohydrolase
Spb1_RS07750	COG0811	peptide transport
Spb1_RS07765	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Spb1_RS07770	COG1132	(ABC) transporter
Spb1_RS07775	COG1132	(ABC) transporter
Spb1_RS07785	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Spb1_RS07790	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Spb1_RS07790	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Spb1_RS07795	COG0475	glutathione-regulated potassium exporter activity
Spb1_RS07800	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Spb1_RS07810	COG0563	adenylate kinase activity
Spb1_RS07815	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Spb1_RS07825	COG1030	water channel activity
Spb1_RS07835	COG0673	inositol 2-dehydrogenase activity
Spb1_RS07840	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Spb1_RS07845	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
Spb1_RS07855	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Spb1_RS07860	COG0254	rRNA binding
Spb1_RS07865	COG1252	NADH dehydrogenase
Spb1_RS07910	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Spb1_RS07915	COG2217	Heavy metal translocating P-type atpase
Spb1_RS07925	COG1132	(ABC) transporter
Spb1_RS07930	COG3119	arylsulfatase activity
Spb1_RS07950	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Spb1_RS07955	COG0463	Glycosyl transferase, family 2
Spb1_RS07975	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Spb1_RS08010	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Spb1_RS08010	COG2169	Transcriptional regulator
Spb1_RS08030	COG0733	neurotransmitter:sodium symporter activity
Spb1_RS08030	COG0733	neurotransmitter:sodium symporter activity
Spb1_RS08035	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Spb1_RS08045	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Spb1_RS08050	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Spb1_RS08050	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Spb1_RS08065	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
Spb1_RS08080	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Spb1_RS08110	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
Spb1_RS08115	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
Spb1_RS08145	COG1090	epimerase
Spb1_RS08170	COG0556	nucleotide-excision repair
Spb1_RS08190	COG0515	serine threonine protein kinase
Spb1_RS08235	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
Spb1_RS08285	COG0681	Belongs to the peptidase S26 family
Spb1_RS08290	COG1137	ATPase activity
Spb1_RS08295	COG0772	Belongs to the SEDS family
Spb1_RS08325	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
Spb1_RS08330	COG0463	Glycosyl transferase, family 2
Spb1_RS08335	COG2373	Large extracellular alpha-helical protein
Spb1_RS08355	COG0793	Belongs to the peptidase S41A family
Spb1_RS08360	COG2319	Wd-40 repeat
Spb1_RS08370	COG0596	Alpha beta hydrolase
Spb1_RS08395	COG1028	Short-chain dehydrogenase reductase Sdr
Spb1_RS08405	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
Spb1_RS08410	COG1191	sigma factor activity
Spb1_RS08425	COG1419	protein localization to endoplasmic reticulum
Spb1_RS08430	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Spb1_RS08450	COG0297	glycogen (starch) synthase activity
Spb1_RS08460	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Spb1_RS08460	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Spb1_RS08465	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Spb1_RS08470	COG0772	Belongs to the SEDS family
Spb1_RS08495	COG1196	nuclear chromosome segregation
Spb1_RS08500	COG1706	bacterial-type flagellum-dependent cell motility
Spb1_RS08520	COG0071	Belongs to the small heat shock protein (HSP20) family
Spb1_RS08545	COG1331	Highly conserved protein containing a thioredoxin domain
Spb1_RS08550	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Spb1_RS08555	COG4974	Belongs to the 'phage' integrase family
Spb1_RS08565	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Spb1_RS08570	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
Spb1_RS08575	COG4948	Mandelate Racemase Muconate Lactonizing
Spb1_RS08590	COG0440	acetolactate synthase activity
Spb1_RS08595	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Spb1_RS08600	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Spb1_RS08605	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Spb1_RS08625	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
Spb1_RS08640	COG0039	L-malate dehydrogenase activity
Spb1_RS08695	COG3119	arylsulfatase activity
Spb1_RS08715	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Spb1_RS08720	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Spb1_RS08730	COG0514	ATP-dependent DNA helicase (RecQ)
Spb1_RS08755	COG0515	serine threonine protein kinase
Spb1_RS08755	COG2815	serine threonine protein kinase
Spb1_RS08765	COG1214	PFAM Peptidase M22, glycoprotease
Spb1_RS08775	COG1217	gtp-binding protein TYPA
Spb1_RS08800	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Spb1_RS08805	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
Spb1_RS08810	COG4581	dead DEAH box helicase
Spb1_RS08815	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
Spb1_RS08820	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Spb1_RS08825	COG3104	oligopeptide transport
Spb1_RS08840	COG1082	Xylose isomerase domain protein TIM barrel
Spb1_RS08845	COG0126	phosphoglycerate kinase activity
Spb1_RS08890	COG0484	heat shock protein binding
Spb1_RS08900	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Spb1_RS08925	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
Spb1_RS08975	COG0438	transferase activity, transferring glycosyl groups
Spb1_RS08985	COG0673	inositol 2-dehydrogenase activity
Spb1_RS08995	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
Spb1_RS09000	COG2115	Belongs to the xylose isomerase family
Spb1_RS09015	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Spb1_RS09045	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Spb1_RS09050	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Spb1_RS09055	COG4956	integral membrane protein (PIN domain superfamily)
Spb1_RS09070	COG0778	Nitroreductase
Spb1_RS09080	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
Spb1_RS09100	COG1045	serine acetyltransferase
Spb1_RS09120	COG0463	Glycosyl transferase, family 2
Spb1_RS09145	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Spb1_RS09160	COG2066	Belongs to the glutaminase family
Spb1_RS09165	COG2045	Belongs to the ComB family
Spb1_RS09170	COG0822	iron-sulfur transferase activity
Spb1_RS09175	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Spb1_RS09180	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Spb1_RS09185	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
Spb1_RS09190	COG0587	DNA-directed DNA polymerase activity
Spb1_RS09205	COG2135	peptidase activity
Spb1_RS09210	COG0649	NAD binding
Spb1_RS09215	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Spb1_RS09220	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Spb1_RS09235	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
Spb1_RS09255	COG0018	arginyl-trna synthetase
Spb1_RS09260	COG0799	negative regulation of ribosome biogenesis
Spb1_RS09265	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Spb1_RS09270	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Spb1_RS09275	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Spb1_RS09285	COG2205	protein histidine kinase activity
Spb1_RS09285	COG3437	response regulator, receiver
Spb1_RS09285	COG3850	Histidine kinase
Spb1_RS09285	COG4999	Histidine kinase
Spb1_RS09290	COG0343	queuine tRNA-ribosyltransferase activity
Spb1_RS09300	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Spb1_RS09310	COG0470	DNA polymerase III
Spb1_RS09315	COG0300	oxidoreductase activity
Spb1_RS09320	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Spb1_RS09340	COG3956	TIGRFAM MazG family protein
Spb1_RS09400	COG0515	serine threonine protein kinase
Spb1_RS09400	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Spb1_RS09420	COG2135	peptidase activity
Spb1_RS09580	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Spb1_RS09590	COG0243	molybdopterin cofactor binding
Spb1_RS09600	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Spb1_RS09610	COG2084	Dehydrogenase
Spb1_RS09620	COG1850	ribulose-bisphosphate carboxylase activity
Spb1_RS09625	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Spb1_RS09635	COG1363	Peptidase, m42
Spb1_RS09640	COG1074	ATP-dependent DNA helicase activity
Spb1_RS09660	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
Spb1_RS09670	COG2264	protein methyltransferase activity
Spb1_RS09675	COG1643	Atp-dependent helicase
Spb1_RS09685	COG1573	uracil-dna glycosylase
Spb1_RS09695	COG1940	carbohydrate kinase activity
Spb1_RS09710	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Spb1_RS09715	COG0569	domain protein
Spb1_RS09735	COG4555	ABC transporter
Spb1_RS09770	COG0616	signal peptide processing
Spb1_RS09780	COG0601	transmembrane transport
Spb1_RS09785	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Spb1_RS09810	COG1640	4-alpha-glucanotransferase
Spb1_RS09825	COG2814	Major facilitator Superfamily
Spb1_RS09855	COG0714	Associated with various cellular activities
Spb1_RS09875	COG0138	bifunctional purine biosynthesis protein purh
Spb1_RS09885	COG0527	aspartate kinase activity
Spb1_RS09890	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Spb1_RS09890	COG2813	Specifically methylates the guanine in position
Spb1_RS09895	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Spb1_RS09920	COG1678	Uncharacterized ACR, COG1678
Spb1_RS09960	COG0702	epimerase
Spb1_RS09965	COG4762	Protein conserved in bacteria
Spb1_RS10000	COG3119	arylsulfatase activity
Spb1_RS10005	COG3119	arylsulfatase activity
Spb1_RS10015	COG3119	arylsulfatase activity
Spb1_RS10045	COG3119	arylsulfatase activity
Spb1_RS10050	COG3119	arylsulfatase activity
Spb1_RS10070	COG0657	acetylesterase activity
Spb1_RS10075	COG3119	arylsulfatase activity
Spb1_RS10130	COG0673	inositol 2-dehydrogenase activity
Spb1_RS10170	COG2197	response regulator
Spb1_RS10180	COG0446	pyridine nucleotide-disulphide oxidoreductase
Spb1_RS10185	COG1063	alcohol dehydrogenase
Spb1_RS10250	COG2226	methyltransferase
Spb1_RS10265	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Spb1_RS10290	COG0848	biopolymer transport protein
Spb1_RS10310	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
Spb1_RS10315	COG4191	Histidine kinase
Spb1_RS10320	COG2204	response regulator
Spb1_RS10365	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
Spb1_RS10375	COG2226	methyltransferase
Spb1_RS10390	COG1335	isochorismatase
Spb1_RS10410	COG4762	Protein conserved in bacteria
Spb1_RS10415	COG0702	epimerase
Spb1_RS10435	COG3256	nitric oxide reductase
Spb1_RS10465	COG0640	Transcriptional regulator
Spb1_RS10470	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Spb1_RS10485	COG4974	Belongs to the 'phage' integrase family
Spb1_RS10500	COG2255	four-way junction helicase activity
Spb1_RS10545	COG1396	sequence-specific DNA binding
Spb1_RS10550	COG0210	DNA helicase
Spb1_RS10570	COG1196	nuclear chromosome segregation
Spb1_RS10655	COG0156	8-amino-7-oxononanoate synthase activity
Spb1_RS10665	COG0724	RNA recognition motif
Spb1_RS10690	COG0523	cobalamin synthesis protein
Spb1_RS10700	COG1215	transferase activity, transferring glycosyl groups
Spb1_RS10735	COG0745	RESPONSE REGULATOR receiver
Spb1_RS10745	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Spb1_RS10750	COG0581	inorganic phosphate transmembrane transporter activity
Spb1_RS10755	COG0573	inorganic phosphate transmembrane transporter activity
Spb1_RS10760	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Spb1_RS10765	COG5002	protein histidine kinase activity
Spb1_RS10780	COG2308	Evidence 4 Homologs of previously reported genes of
Spb1_RS10790	COG2307	Protein conserved in bacteria
Spb1_RS10790	COG2308	Evidence 4 Homologs of previously reported genes of
Spb1_RS10800	COG3119	arylsulfatase activity
Spb1_RS10805	COG0280	phosphate acetyltransferase
Spb1_RS10810	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
Spb1_RS10825	COG2066	Belongs to the glutaminase family
Spb1_RS10845	COG2195	Cleaves the N-terminal amino acid of tripeptides
Spb1_RS10850	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
Spb1_RS10855	COG0490	domain, Protein
Spb1_RS10855	COG0471	metal ion transport
Spb1_RS10910	COG3119	arylsulfatase activity
Spb1_RS10920	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Spb1_RS10935	COG0693	protein deglycase activity
Spb1_RS10955	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
Spb1_RS10970	COG0673	inositol 2-dehydrogenase activity
Spb1_RS10995	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Spb1_RS11000	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Spb1_RS11010	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
Spb1_RS11015	COG0594	ribonuclease P activity
Spb1_RS11020	COG0710	3-dehydroquinate dehydratase activity
Spb1_RS11045	COG0113	porphobilinogen synthase activity
Spb1_RS11075	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Spb1_RS11105	COG0140	phosphoribosyl-ATP diphosphatase activity
Spb1_RS11115	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Spb1_RS11140	COG3119	arylsulfatase activity
Spb1_RS11140	COG3408	Glycogen debranching enzyme
Spb1_RS11145	COG3119	arylsulfatase activity
Spb1_RS11150	COG3119	arylsulfatase activity
Spb1_RS11165	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Spb1_RS11170	COG0736	holo-[acyl-carrier-protein] synthase activity
Spb1_RS11180	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
Spb1_RS11200	COG0371	Dehydrogenase
Spb1_RS11205	COG0726	polysaccharide deacetylase
Spb1_RS11245	COG0724	RNA recognition motif
Spb1_RS11355	COG0235	Class ii aldolase
Spb1_RS11360	COG3119	arylsulfatase activity
Spb1_RS11365	COG0673	inositol 2-dehydrogenase activity
Spb1_RS11385	COG1410	methionine synthase
Spb1_RS11385	COG0646	methionine synthase
Spb1_RS11425	COG0673	inositol 2-dehydrogenase activity
Spb1_RS11450	COG3293	Transposase
Spb1_RS11500	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Spb1_RS11555	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Spb1_RS11595	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Spb1_RS11605	COG0539	negative regulation of cytoplasmic translation
Spb1_RS11605	COG2183	response to ionizing radiation
Spb1_RS11615	COG0463	Glycosyl transferase, family 2
Spb1_RS11620	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Spb1_RS11655	COG1216	Glycosyl transferase, family 2
Spb1_RS11660	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Spb1_RS11665	COG0492	ferredoxin-NADP+ reductase activity
Spb1_RS11670	COG0006	proline dipeptidase activity
Spb1_RS11675	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Spb1_RS11710	COG3622	Belongs to the hyi family
Spb1_RS11730	COG1671	Belongs to the UPF0178 family
Spb1_RS11735	COG3119	arylsulfatase activity
Spb1_RS11740	COG0488	(ABC) transporter
Spb1_RS11745	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
Spb1_RS11750	COG0488	(ABC) transporter
Spb1_RS11770	COG0423	glycine-tRNA ligase activity
Spb1_RS11790	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Spb1_RS11810	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
Spb1_RS11835	COG3708	Transcriptional regulator
Spb1_RS11835	COG2207	Transcriptional regulator
Spb1_RS11840	COG1012	belongs to the aldehyde dehydrogenase family
Spb1_RS11855	COG1028	Short-chain dehydrogenase reductase Sdr
Spb1_RS11865	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Spb1_RS11875	COG3977	Valine--pyruvate aminotransferase
Spb1_RS11880	COG2204	response regulator
Spb1_RS11920	COG1229	Formylmethanofuran dehydrogenase subunit A
Spb1_RS11930	COG0714	Associated with various cellular activities
Spb1_RS11940	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Spb1_RS11950	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
Spb1_RS11955	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Spb1_RS11960	COG3540	Alkaline phosphatase
Spb1_RS11965	COG0811	peptide transport
Spb1_RS11975	COG0848	biopolymer transport protein
Spb1_RS11995	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Spb1_RS12000	COG0432	Pfam Uncharacterised protein family UPF0047
Spb1_RS12025	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Spb1_RS12030	COG0706	membrane insertase activity
Spb1_RS12030	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Spb1_RS12040	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Spb1_RS12050	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Spb1_RS12055	COG0504	CTP synthase activity
Spb1_RS12060	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
Spb1_RS12065	COG4191	Histidine kinase
Spb1_RS12070	COG4566	intracellular signal transduction
Spb1_RS12085	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Spb1_RS12125	COG1796	DNA polymerase
Spb1_RS12125	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Spb1_RS12135	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Spb1_RS12170	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Spb1_RS12175	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
Spb1_RS12180	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
Spb1_RS12190	COG0039	L-malate dehydrogenase activity
Spb1_RS12195	COG0235	Class ii aldolase
Spb1_RS12245	COG4869	propanediol catabolic process
Spb1_RS12255	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Spb1_RS12280	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Spb1_RS12285	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Spb1_RS12290	COG0024	Methionine aminopeptidase
Spb1_RS12310	COG0179	Fumarylacetoacetate (FAA) hydrolase
Spb1_RS12320	COG2046	Belongs to the sulfate adenylyltransferase family
Spb1_RS12335	COG0019	diaminopimelate decarboxylase activity
Spb1_RS12340	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Spb1_RS12345	COG0151	Belongs to the GarS family
Spb1_RS12360	COG0281	malic enzyme
Spb1_RS12375	COG0768	penicillin binding
Spb1_RS12390	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
Spb1_RS12395	COG0438	transferase activity, transferring glycosyl groups
Spb1_RS12430	COG0326	Molecular chaperone. Has ATPase activity
Spb1_RS12435	COG0714	Associated with various cellular activities
Spb1_RS12475	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Spb1_RS12485	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Spb1_RS12490	COG0673	inositol 2-dehydrogenase activity
Spb1_RS12530	COG0483	inositol monophosphate 1-phosphatase activity
Spb1_RS12545	COG1968	undecaprenyl-diphosphatase activity
Spb1_RS12570	COG0287	Prephenate dehydrogenase
Spb1_RS12575	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Spb1_RS12585	COG2379	hydroxypyruvate reductase
Spb1_RS12615	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Spb1_RS12620	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Spb1_RS12625	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Spb1_RS12645	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Spb1_RS12695	COG2165	general secretion pathway protein
Spb1_RS12700	COG0009	L-threonylcarbamoyladenylate synthase
Spb1_RS12710	COG1222	aaa ATPase
Spb1_RS12725	COG1560	Kdo2-lipid A biosynthetic process
Spb1_RS12740	COG0673	inositol 2-dehydrogenase activity
Spb1_RS12750	COG1012	belongs to the aldehyde dehydrogenase family
Spb1_RS12780	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Spb1_RS12785	COG0640	Transcriptional regulator
Spb1_RS12790	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
Spb1_RS12795	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Spb1_RS12805	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Spb1_RS12810	COG1054	Belongs to the UPF0176 family
Spb1_RS12820	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
Spb1_RS12830	COG1063	alcohol dehydrogenase
Spb1_RS12835	COG1657	PFAM Prenyltransferase squalene oxidase
Spb1_RS12840	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
Spb1_RS12845	COG0784	Response regulator, receiver
Spb1_RS12845	COG0643	Histidine kinase
Spb1_RS12845	COG2198	Histidine kinase
Spb1_RS12850	COG0835	chemotaxis
Spb1_RS12855	COG0840	transmembrane signaling receptor activity
Spb1_RS12860	COG0745	RESPONSE REGULATOR receiver
Spb1_RS12885	COG2204	response regulator
Spb1_RS12905	COG1449	Belongs to the glycosyl hydrolase 57 family
Spb1_RS12910	COG0746	molybdenum cofactor guanylyltransferase activity
Spb1_RS12935	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Spb1_RS12950	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Spb1_RS12995	COG0165	Argininosuccinate lyase
Spb1_RS13005	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
Spb1_RS13010	COG0602	queuosine metabolic process
Spb1_RS13105	COG0424	maF-like protein
Spb1_RS13130	COG0667	Aldo Keto reductase
Spb1_RS13155	COG0577	efflux transmembrane transporter activity
Spb1_RS13155	COG1136	(ABC) transporter
Spb1_RS13160	COG0577	efflux transmembrane transporter activity
Spb1_RS13160	COG1136	(ABC) transporter
Spb1_RS13165	COG0534	Mate efflux family protein
Spb1_RS13195	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
Spb1_RS13200	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Spb1_RS13235	COG0521	Mo-molybdopterin cofactor biosynthetic process
Spb1_RS13265	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
Spb1_RS13275	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Spb1_RS13280	COG1722	exodeoxyribonuclease VII activity
Spb1_RS13285	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Spb1_RS13290	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Spb1_RS13295	COG1121	(ABC) transporter
Spb1_RS13300	COG0803	Belongs to the bacterial solute-binding protein 9 family
Spb1_RS13305	COG3781	membrane
Spb1_RS13310	COG0778	Nitroreductase
Spb1_RS13315	COG1105	Belongs to the carbohydrate kinase PfkB family
Spb1_RS13335	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
Spb1_RS13355	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Spb1_RS13365	COG1418	mRNA catabolic process
Spb1_RS13370	COG0037	tRNA processing
Spb1_RS13400	COG0640	Transcriptional regulator
Spb1_RS13430	COG0105	UTP biosynthetic process
Spb1_RS13435	COG0505	Belongs to the CarA family
Spb1_RS13440	COG0640	Transcriptional regulator
Spb1_RS13455	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Spb1_RS13470	COG1228	amidohydrolase
Spb1_RS13475	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Spb1_RS13505	COG0542	response to heat
Spb1_RS13510	COG0443	Heat shock 70 kDa protein
Spb1_RS13520	COG0149	triose-phosphate isomerase activity
Spb1_RS13530	COG1561	YicC-like family, N-terminal region
Spb1_RS13535	COG0194	GDP metabolic process
Spb1_RS13540	COG1758	RNA polymerase activity
Spb1_RS13545	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Spb1_RS13550	COG2912	Transglutaminase-like superfamily
Spb1_RS13570	COG0800	Aldolase
Spb1_RS13580	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Spb1_RS13590	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Spb1_RS13595	COG1127	ABC transporter
Spb1_RS13610	COG0525	valine-tRNA ligase activity
Spb1_RS13615	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Spb1_RS13625	COG0586	Pfam SNARE associated Golgi protein
Spb1_RS13635	COG1396	sequence-specific DNA binding
Spb1_RS13640	COG1063	alcohol dehydrogenase
Spb1_RS13645	COG0156	8-amino-7-oxononanoate synthase activity
Spb1_RS13655	COG2860	membrane
Spb1_RS13660	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Spb1_RS13665	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Spb1_RS13730	COG1234	tRNA 3'-trailer cleavage
Spb1_RS13735	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Spb1_RS13750	COG1028	Short-chain dehydrogenase reductase Sdr
Spb1_RS13760	COG0275	rRNA processing
Spb1_RS13790	COG0488	(ABC) transporter
Spb1_RS13795	COG0163	prenyltransferase activity
Spb1_RS13800	COG2226	methyltransferase
Spb1_RS13805	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
Spb1_RS13850	COG3386	PFAM SMP-30 Gluconolaconase
Spb1_RS13870	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Spb1_RS13885	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Spb1_RS13900	COG1490	D-aminoacyl-tRNA deacylase activity
Spb1_RS13905	COG0825	malonyl-CoA metabolic process
Spb1_RS13910	COG0515	serine threonine protein kinase
Spb1_RS13910	COG2815	serine threonine protein kinase
Spb1_RS13920	COG2890	protein-(glutamine-N5) methyltransferase activity
Spb1_RS13925	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Spb1_RS13960	COG0515	serine threonine protein kinase
Spb1_RS13960	COG2815	serine threonine protein kinase
Spb1_RS13965	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Spb1_RS13970	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Spb1_RS13980	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Spb1_RS14000	COG0134	indole-3-glycerol-phosphate synthase activity
Spb1_RS14010	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Spb1_RS14025	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Spb1_RS14035	COG1131	(ABC) transporter
Spb1_RS14060	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Spb1_RS14070	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Spb1_RS14095	COG2832	Protein of unknown function (DUF454)
Spb1_RS14105	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
Spb1_RS14110	COG1028	Short-chain dehydrogenase reductase Sdr
Spb1_RS14145	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Spb1_RS14165	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Spb1_RS14175	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
Spb1_RS14190	COG1702	phosphate starvation-inducible protein PhoH
Spb1_RS14195	COG1480	7TM receptor with intracellular HD hydrolase
Spb1_RS14200	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Spb1_RS14215	COG0714	Associated with various cellular activities
Spb1_RS14235	COG1321	iron dependent repressor
Spb1_RS14240	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Spb1_RS14245	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Spb1_RS14250	COG1562	ergosterol biosynthetic process
Spb1_RS14260	COG1160	GTP binding
Spb1_RS14290	COG1595	DNA-templated transcription, initiation
Spb1_RS14295	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Spb1_RS14300	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
Spb1_RS14325	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
Spb1_RS14330	COG2124	cytochrome p450
Spb1_RS14335	COG1301	dicarboxylic acid transport
Spb1_RS14340	COG0072	phenylalanine-tRNA ligase activity
Spb1_RS14350	COG0745	RESPONSE REGULATOR receiver
Spb1_RS14365	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Spb1_RS14370	COG0540	Belongs to the ATCase OTCase family
Spb1_RS14375	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Spb1_RS14385	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
Spb1_RS14390	COG0004	ammonium transporteR
Spb1_RS14395	COG0347	Belongs to the P(II) protein family
Spb1_RS14400	COG0347	Belongs to the P(II) protein family
Spb1_RS14405	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
Spb1_RS14430	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Spb1_RS14440	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Spb1_RS14450	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
Spb1_RS14455	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
Spb1_RS14460	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
Spb1_RS14475	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
Spb1_RS14475	COG0321	lipoyl(octanoyl) transferase activity
Spb1_RS14485	COG3119	arylsulfatase activity
Spb1_RS14500	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
Spb1_RS14515	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Spb1_RS14520	COG0475	glutathione-regulated potassium exporter activity
Spb1_RS14525	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Spb1_RS14545	COG0559	Belongs to the binding-protein-dependent transport system permease family
Spb1_RS14555	COG0411	ABC transporter
Spb1_RS14600	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
Spb1_RS14605	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Spb1_RS14620	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Spb1_RS14625	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
Spb1_RS14645	COG1136	(ABC) transporter
Spb1_RS14655	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Spb1_RS14660	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Spb1_RS14670	COG0443	Heat shock 70 kDa protein
Spb1_RS14705	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Spb1_RS14760	COG4974	Belongs to the 'phage' integrase family
Spb1_RS14765	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Spb1_RS14770	COG0673	inositol 2-dehydrogenase activity
Spb1_RS14790	COG0515	serine threonine protein kinase
Spb1_RS14810	COG3494	Protein of unknown function (DUF1009)
Spb1_RS14815	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Spb1_RS14820	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
Spb1_RS14840	COG1519	Transferase
Spb1_RS14845	COG0038	chloride channel
Spb1_RS14850	COG0653	protein targeting
Spb1_RS14855	COG0204	Acyl-transferase
Spb1_RS14855	COG0318	PFAM AMP-dependent synthetase and ligase
Spb1_RS14905	COG3119	arylsulfatase activity
Spb1_RS14930	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Spb1_RS14935	COG0396	ATPase activity
Spb1_RS14940	COG0719	Fe-S assembly protein
Spb1_RS14960	COG1082	Xylose isomerase domain protein TIM barrel
Spb1_RS14970	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
Spb1_RS14990	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
Spb1_RS15000	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
Spb1_RS15005	COG0248	Ppx GppA phosphatase
Spb1_RS15015	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Spb1_RS15020	COG0045	succinate-CoA ligase (ADP-forming) activity
Spb1_RS15030	COG0720	synthase
Spb1_RS15045	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Spb1_RS15055	COG2183	response to ionizing radiation
Spb1_RS15065	COG0784	Response regulator, receiver
Spb1_RS15065	COG2198	Histidine kinase
Spb1_RS15065	COG5002	protein histidine kinase activity
Spb1_RS15090	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Spb1_RS15090	COG0574	Belongs to the PEP-utilizing enzyme family
Spb1_RS15095	COG1073	alpha beta
Spb1_RS15120	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Spb1_RS15135	COG2255	four-way junction helicase activity
Spb1_RS15170	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Spb1_RS15185	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Spb1_RS15190	COG0142	geranyltranstransferase activity
Spb1_RS15195	COG0215	cysteine-tRNA ligase activity
Spb1_RS15205	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Spb1_RS15210	COG0515	serine threonine protein kinase
Spb1_RS15210	COG2815	serine threonine protein kinase
Spb1_RS15215	COG0632	four-way junction helicase activity
Spb1_RS15220	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Spb1_RS15220	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Spb1_RS15230	COG0557	exoribonuclease II activity
Spb1_RS15240	COG1053	succinate dehydrogenase
Spb1_RS15245	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
Spb1_RS15255	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Spb1_RS15275	COG3119	arylsulfatase activity
Spb1_RS15295	COG1410	methionine synthase
Spb1_RS15295	COG0646	methionine synthase
Spb1_RS15315	COG0658	competence protein
Spb1_RS15325	COG0783	Belongs to the Dps family
Spb1_RS15345	COG1774	PSP1 C-terminal conserved region
Spb1_RS15350	COG0612	Peptidase, M16
Spb1_RS15355	COG0612	Peptidase, M16
Spb1_RS15370	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Spb1_RS15385	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Spb1_RS15390	COG0673	inositol 2-dehydrogenase activity
Spb1_RS15420	COG0442	prolyl-tRNA aminoacylation
Spb1_RS15425	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Spb1_RS15430	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Spb1_RS15435	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Spb1_RS15440	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Spb1_RS15445	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Spb1_RS15450	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Spb1_RS15490	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Spb1_RS15495	COG0793	Belongs to the peptidase S41A family
Spb1_RS15505	COG1136	(ABC) transporter
Spb1_RS15510	COG4591	ABC-type transport system involved in lipoprotein release permease component
Spb1_RS15515	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Spb1_RS15530	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Spb1_RS15535	COG0459	protein refolding
Spb1_RS15555	COG3119	arylsulfatase activity
Spb1_RS15570	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
Spb1_RS15580	COG0445	tRNA wobble uridine modification
Spb1_RS15590	COG4948	Mandelate Racemase Muconate Lactonizing
Spb1_RS15620	COG3852	Histidine kinase
Spb1_RS15640	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Spb1_RS15650	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Spb1_RS15670	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Spb1_RS15675	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Spb1_RS15680	COG0195	Participates in both transcription termination and antitermination
Spb1_RS15680	COG2251	uridine kinase activity
Spb1_RS15695	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Spb1_RS15705	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Spb1_RS15710	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Spb1_RS15715	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Spb1_RS15720	COG0416	fatty acid biosynthetic process
Spb1_RS15725	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Spb1_RS15740	COG0288	reversible hydration of carbon dioxide
Spb1_RS15755	COG0220	tRNA (guanine-N7-)-methyltransferase activity
Spb1_RS15790	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
Spb1_RS15800	COG0189	ligase activity
Spb1_RS15805	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
Spb1_RS15815	COG0564	pseudouridine synthase activity
Spb1_RS15820	COG0657	acetylesterase activity
Spb1_RS15835	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Spb1_RS15840	COG0698	ribose 5-phosphate isomerase
Spb1_RS15845	COG0509	glycine decarboxylation via glycine cleavage system
Spb1_RS15850	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Spb1_RS15855	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Spb1_RS15860	COG0095	Lipoate-protein ligase
Spb1_RS15875	COG1595	DNA-templated transcription, initiation
Spb1_RS15890	COG0148	phosphopyruvate hydratase activity
Spb1_RS15895	COG1230	cation diffusion facilitator family transporter
Spb1_RS15915	COG0205	6-phosphofructokinase activity
Spb1_RS15925	COG0367	asparagine synthase
Spb1_RS15950	COG1077	Cell shape determining protein MreB Mrl
Spb1_RS15965	COG0657	acetylesterase activity
Spb1_RS15970	COG0305	Participates in initiation and elongation during chromosome replication
Spb1_RS15975	COG0359	binds to the 23S rRNA
Spb1_RS15980	COG0629	single-stranded DNA binding
Spb1_RS15990	COG0193	aminoacyl-tRNA hydrolase activity
Spb1_RS15995	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Spb1_RS16005	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
Spb1_RS16015	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Spb1_RS16025	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Spb1_RS16035	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
Spb1_RS16040	COG0596	Alpha beta hydrolase
Spb1_RS16045	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Spb1_RS16080	COG4106	trans-aconitate 2-methyltransferase activity
Spb1_RS16120	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Spb1_RS16140	COG3604	Transcriptional regulator
Spb1_RS16150	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Spb1_RS16150	COG0189	ligase activity
Spb1_RS16155	COG0189	ligase activity
Spb1_RS16155	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Spb1_RS16160	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
Spb1_RS16185	COG0805	protein transport
Spb1_RS16190	COG0205	6-phosphofructokinase activity
Spb1_RS16205	COG0277	FAD linked oxidase domain protein
Spb1_RS16215	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Spb1_RS16220	COG1566	PFAM secretion protein HlyD family protein
Spb1_RS16230	COG1294	oxidase, subunit
Spb1_RS16235	COG1271	oxidase subunit
Spb1_RS16260	COG0698	ribose 5-phosphate isomerase
Spb1_RS16265	COG0493	'glutamate synthase
Spb1_RS16270	COG0069	glutamate synthase activity
Spb1_RS16270	COG0067	glutamate synthase
Spb1_RS16270	COG0070	glutamate synthase
Spb1_RS16295	COG1918	ferrous iron import across plasma membrane
Spb1_RS16295	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Spb1_RS16300	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
Spb1_RS16315	COG4786	Flagellar basal body rod
Spb1_RS16330	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
Spb1_RS16365	COG3938	Belongs to the proline racemase family
Spb1_RS16370	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Spb1_RS16375	COG4948	Mandelate Racemase Muconate Lactonizing
Spb1_RS16385	COG3781	membrane
Spb1_RS16390	COG1028	Short-chain dehydrogenase reductase Sdr
Spb1_RS16415	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Spb1_RS16420	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Spb1_RS16425	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Spb1_RS16435	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Spb1_RS16450	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Spb1_RS16470	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Spb1_RS16480	COG3119	arylsulfatase activity
Spb1_RS16520	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Spb1_RS16530	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Spb1_RS16555	COG0515	serine threonine protein kinase
Spb1_RS16555	COG2815	serine threonine protein kinase
Spb1_RS16570	COG5002	protein histidine kinase activity
Spb1_RS16575	COG0745	RESPONSE REGULATOR receiver
Spb1_RS16580	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Spb1_RS16595	COG2204	response regulator
Spb1_RS16600	COG0784	Response regulator, receiver
Spb1_RS16600	COG2205	protein histidine kinase activity
Spb1_RS16600	COG5002	protein histidine kinase activity
Spb1_RS16615	COG1132	(ABC) transporter
Spb1_RS16620	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Spb1_RS16625	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Spb1_RS16630	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Spb1_RS16635	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Spb1_RS16640	COG2088	sporulation resulting in formation of a cellular spore
Spb1_RS16660	COG0714	Associated with various cellular activities
Spb1_RS16680	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Spb1_RS16710	COG4115	mRNA cleavage
Spb1_RS16715	COG2161	toxin-antitoxin pair type II binding
Spb1_RS16755	COG2001	Belongs to the MraZ family
Spb1_RS16765	COG2207	Transcriptional regulator
Spb1_RS16765	COG1609	Transcriptional regulator
Spb1_RS16825	COG0251	oxidation-reduction process
Spb1_RS16830	COG0564	pseudouridine synthase activity
Spb1_RS16840	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Spb1_RS16860	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Spb1_RS16870	COG0107	imidazoleglycerol-phosphate synthase activity
Spb1_RS16885	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
Spb1_RS16900	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Spb1_RS16945	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Spb1_RS16965	COG0515	serine threonine protein kinase
Spb1_RS16965	COG0457	Tetratricopeptide repeat
Spb1_RS16995	COG4120	Belongs to the binding-protein-dependent transport system permease family
Spb1_RS17000	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
Spb1_RS17010	COG2095	MarC family integral membrane protein
Spb1_RS17025	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Spb1_RS17050	COG3706	GGDEF domain
Spb1_RS17055	COG0745	RESPONSE REGULATOR receiver
Spb1_RS17065	COG2197	response regulator
Spb1_RS17075	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Spb1_RS17080	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Spb1_RS17085	COG2239	Acts as a magnesium transporter
Spb1_RS17100	COG1011	Hydrolase
Spb1_RS17105	COG2755	lipolytic protein G-D-S-L family
Spb1_RS17105	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
Spb1_RS17140	COG0436	Aminotransferase
Spb1_RS17150	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Spb1_RS17155	COG1475	DNA binding
Spb1_RS17185	COG0284	orotidine-5'-phosphate decarboxylase activity
Spb1_RS17190	COG2755	lipolytic protein G-D-S-L family
Spb1_RS17190	COG0657	acetylesterase activity
Spb1_RS17200	COG2226	methyltransferase
Spb1_RS17215	COG0386	Belongs to the glutathione peroxidase family
Spb1_RS17220	COG1408	metallophosphoesterase
Spb1_RS17225	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
Spb1_RS17290	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Spb1_RS17300	COG0459	protein refolding
Spb1_RS17305	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Spb1_RS17310	COG0459	protein refolding
Spb1_RS17335	COG2204	response regulator
Spb1_RS17340	COG0662	Cupin 2, conserved barrel domain protein
Spb1_RS17340	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
Spb1_RS17355	COG1454	alcohol dehydrogenase
Spb1_RS17365	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Spb1_RS17375	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Spb1_RS17395	COG2211	Major facilitator Superfamily
Spb1_RS17410	COG1845	cytochrome c oxidase, subunit III
Spb1_RS17415	COG0109	protoheme IX farnesyltransferase activity
Spb1_RS17425	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Spb1_RS17430	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
Spb1_RS17450	COG0372	Belongs to the citrate synthase family
Spb1_RS17455	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Spb1_RS17465	COG0563	adenylate kinase activity
Spb1_RS17470	COG0826	peptidase U32
Spb1_RS17475	COG1596	polysaccharide export
Spb1_RS17475	COG1555	photosystem II stabilization
Spb1_RS17485	COG1054	Belongs to the UPF0176 family
Spb1_RS17500	COG0537	adenosine 5'-monophosphoramidase activity
Spb1_RS17510	COG1064	alcohol dehydrogenase
Spb1_RS17520	COG0316	Belongs to the HesB IscA family
Spb1_RS17530	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
Spb1_RS17550	COG2766	serine protein kinase
Spb1_RS17555	COG2718	Belongs to the UPF0229 family
Spb1_RS17560	COG2719	SpoVR family
Spb1_RS17590	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
Spb1_RS17595	COG1201	RNA secondary structure unwinding
Spb1_RS17620	COG1418	mRNA catabolic process
Spb1_RS17630	COG1595	DNA-templated transcription, initiation
Spb1_RS17655	COG1131	(ABC) transporter
Spb1_RS17665	COG0420	3'-5' exonuclease activity
Spb1_RS17670	COG4717	serine-type aminopeptidase activity
Spb1_RS17710	COG0443	Heat shock 70 kDa protein
Spb1_RS17755	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Spb1_RS17765	COG1157	protein secretion by the type III secretion system
Spb1_RS17785	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
Spb1_RS17795	COG0446	pyridine nucleotide-disulphide oxidoreductase
Spb1_RS17800	COG3258	Cytochrome c
Spb1_RS17815	COG0446	pyridine nucleotide-disulphide oxidoreductase
Spb1_RS17820	COG0730	response to heat
Spb1_RS17860	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Spb1_RS17865	COG0604	alcohol dehydrogenase
Spb1_RS17865	COG3321	synthase
Spb1_RS17870	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Spb1_RS17875	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Spb1_RS17885	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Spb1_RS17890	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Spb1_RS17895	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Spb1_RS17900	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Spb1_RS17915	COG0577	efflux transmembrane transporter activity
Spb1_RS17915	COG1136	(ABC) transporter
Spb1_RS17920	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Spb1_RS17925	COG1136	(ABC) transporter
Spb1_RS17925	COG0577	efflux transmembrane transporter activity
Spb1_RS17945	COG1012	belongs to the aldehyde dehydrogenase family
Spb1_RS17945	COG2030	dehydratase
Spb1_RS17955	COG1819	glycosyl
Spb1_RS17975	COG2226	methyltransferase
Spb1_RS17985	COG0604	alcohol dehydrogenase
Spb1_RS18035	COG2226	methyltransferase
Spb1_RS18060	COG2815	serine threonine protein kinase
Spb1_RS18060	COG0515	serine threonine protein kinase
Spb1_RS18115	COG0585	pseudouridine synthase activity
Spb1_RS18120	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Spb1_RS18125	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Spb1_RS18130	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Spb1_RS18135	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Spb1_RS18140	COG1028	Short-chain dehydrogenase reductase Sdr
Spb1_RS18145	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Spb1_RS18200	COG1793	dna ligase
Spb1_RS18205	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Spb1_RS18235	COG4555	ABC transporter
Spb1_RS18240	COG1668	transmembrane transport
Spb1_RS18285	COG1785	Belongs to the alkaline phosphatase family
Spb1_RS18310	COG0577	efflux transmembrane transporter activity
Spb1_RS18310	COG1136	(ABC) transporter
Spb1_RS18320	COG1136	(ABC) transporter
Spb1_RS18355	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Spb1_RS18380	COG1028	Short-chain dehydrogenase reductase Sdr
Spb1_RS18395	COG4208	sulfate ABC transporter
Spb1_RS18400	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
Spb1_RS18405	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
Spb1_RS18425	COG0159	tryptophan synthase activity
Spb1_RS18430	COG0133	tryptophan synthase activity
Spb1_RS18435	COG0528	UMP kinase activity
Spb1_RS18440	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Spb1_RS18445	COG0052	Belongs to the universal ribosomal protein uS2 family
Spb1_RS18470	COG0181	hydroxymethylbilane synthase activity
Spb1_RS18475	COG1040	competence protein
Spb1_RS18480	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
Spb1_RS18485	COG3119	arylsulfatase activity
Spb1_RS18495	COG0405	Gamma-glutamyltransferase
Spb1_RS18530	COG0222	ribosome binding
Spb1_RS18535	COG2205	protein histidine kinase activity
Spb1_RS18540	COG2208	phosphoserine phosphatase activity
Spb1_RS18540	COG2770	Histidine kinase
Spb1_RS18545	COG0671	phosphoesterase, PA-phosphatase related
Spb1_RS18630	COG0129	dihydroxy-acid dehydratase activity
Spb1_RS18645	COG1943	Transposase
Spb1_RS18720	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Spb1_RS18720	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Spb1_RS18730	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Spb1_RS18735	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
Spb1_RS18765	COG0233	cytoplasmic translational termination
Spb1_RS18770	COG0469	pyruvate kinase activity
Spb1_RS18775	COG2205	protein histidine kinase activity
Spb1_RS18775	COG0784	Response regulator, receiver
Spb1_RS18775	COG2198	Histidine kinase
Spb1_RS18775	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Spb1_RS18785	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Spb1_RS18785	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Spb1_RS18790	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Spb1_RS18850	COG1132	(ABC) transporter
Spb1_RS18855	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
Spb1_RS18875	COG0220	tRNA (guanine-N7-)-methyltransferase activity
Spb1_RS18880	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Spb1_RS18900	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Spb1_RS18905	COG3119	arylsulfatase activity
Spb1_RS18910	COG3264	Mechanosensitive ion channel
Spb1_RS18910	COG1196	nuclear chromosome segregation
Spb1_RS18920	COG0626	cystathionine gamma-synthase activity
Spb1_RS18935	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Spb1_RS18945	COG0509	glycine decarboxylation via glycine cleavage system
Spb1_RS18965	COG4589	Belongs to the CDS family
Spb1_RS18985	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Spb1_RS18990	COG0750	zinc metalloprotease
Spb1_RS19005	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Spb1_RS19010	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Spb1_RS19015	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
Spb1_RS19020	COG4335	DNA alkylation repair
Spb1_RS19055	COG2409	Drug exporters of the RND superfamily
Spb1_RS19080	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Spb1_RS19105	COG0740	serine-type endopeptidase activity
Spb1_RS19110	COG0740	serine-type endopeptidase activity
Spb1_RS19115	COG0544	peptidyl-prolyl cis-trans isomerase activity
Spb1_RS19150	COG2814	Major facilitator Superfamily
Spb1_RS19180	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Spb1_RS19185	COG1078	dGTPase activity
Spb1_RS19205	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Spb1_RS19220	COG2815	serine threonine protein kinase
Spb1_RS19220	COG0515	serine threonine protein kinase
Spb1_RS19235	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
Spb1_RS19270	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Spb1_RS19275	COG0321	lipoyl(octanoyl) transferase activity
Spb1_RS19285	COG1690	Belongs to the RtcB family
Spb1_RS19345	COG3119	arylsulfatase activity
Spb1_RS19355	COG2815	serine threonine protein kinase
Spb1_RS19355	COG0515	serine threonine protein kinase