locus-tag	class	description
BBI15_RS00025	COG0569	domain protein
BBI15_RS00050	COG0583	DNA-binding transcription factor activity
BBI15_RS00055	COG2610	gluconate transmembrane transporter activity
BBI15_RS00060	COG1028	Short-chain dehydrogenase reductase Sdr
BBI15_RS00065	COG2267	carboxylic ester hydrolase activity
BBI15_RS00070	COG0398	Pfam SNARE associated Golgi protein
BBI15_RS00075	COG3949	Membrane
BBI15_RS00080	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BBI15_RS00085	COG1268	BioY protein
BBI15_RS00090	COG0366	Alpha amylase catalytic
BBI15_RS00095	COG1940	carbohydrate kinase activity
BBI15_RS00115	COG1609	Transcriptional regulator
BBI15_RS00120	COG0366	Alpha amylase catalytic
BBI15_RS00125	COG0166	Belongs to the GPI family
BBI15_RS00130	COG0768	penicillin binding
BBI15_RS00135	COG0366	Alpha amylase catalytic
BBI15_RS00150	COG0456	acetyltransferase
BBI15_RS00155	COG2508	Transcriptional regulator
BBI15_RS00160	COG0006	proline dipeptidase activity
BBI15_RS00170	COG1473	amidohydrolase
BBI15_RS00175	COG0460	homoserine dehydrogenase
BBI15_RS00180	COG1012	belongs to the aldehyde dehydrogenase family
BBI15_RS00185	COG0129	dihydroxy-acid dehydratase activity
BBI15_RS00190	COG0277	FAD linked oxidase domain protein
BBI15_RS00195	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BBI15_RS00200	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BBI15_RS00200	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BBI15_RS00205	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BBI15_RS00205	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BBI15_RS00210	COG0473	3-isopropylmalate dehydrogenase activity
BBI15_RS00215	COG1028	Short-chain dehydrogenase reductase Sdr
BBI15_RS00220	COG1012	belongs to the aldehyde dehydrogenase family
BBI15_RS00225	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
BBI15_RS00235	COG0714	Associated with various cellular activities
BBI15_RS00240	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
BBI15_RS00245	COG1305	Transglutaminase-like
BBI15_RS00250	COG0519	Catalyzes the synthesis of GMP from XMP
BBI15_RS00250	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BBI15_RS00255	COG2252	PERMEase
BBI15_RS00275	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
BBI15_RS00285	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BBI15_RS00290	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BBI15_RS00295	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BBI15_RS00305	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BBI15_RS00320	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
BBI15_RS00330	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BBI15_RS00340	COG0151	Belongs to the GarS family
BBI15_RS00345	COG0456	acetyltransferase
BBI15_RS00350	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
BBI15_RS00355	COG1470	cell adhesion involved in biofilm formation
BBI15_RS00360	COG4496	protein, YerC YecD
BBI15_RS00370	COG0210	DNA helicase
BBI15_RS00380	COG4851	CamS sex pheromone cAM373 precursor
BBI15_RS00405	COG1597	lipid kinase activity
BBI15_RS00410	COG0494	nUDIX hydrolase
BBI15_RS00415	COG1271	oxidase subunit
BBI15_RS00420	COG1294	oxidase, subunit
BBI15_RS00425	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BBI15_RS00445	COG1309	transcriptional regulator
BBI15_RS00450	COG2814	Major facilitator Superfamily
BBI15_RS00460	COG2309	aminopeptidase activity
BBI15_RS00475	COG3859	Proton-coupled thiamine transporter YuaJ
BBI15_RS00480	COG0024	Methionine aminopeptidase
BBI15_RS00495	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BBI15_RS00500	COG2318	DinB family
BBI15_RS00505	COG0288	reversible hydration of carbon dioxide
BBI15_RS00510	COG1077	Cell shape determining protein MreB Mrl
BBI15_RS00515	COG2309	aminopeptidase activity
BBI15_RS00530	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BBI15_RS00540	COG4840	Belongs to the UPF0435 family
BBI15_RS00555	COG1295	ribonuclease BN
BBI15_RS00560	COG2217	Heavy metal translocating P-type atpase
BBI15_RS00575	COG0477	Major facilitator Superfamily
BBI15_RS00580	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BBI15_RS00585	COG1090	epimerase
BBI15_RS00605	COG1988	membrane-bound metal-dependent
BBI15_RS00610	COG1194	a g-specific adenine glycosylase
BBI15_RS00615	COG1028	Short-chain dehydrogenase reductase Sdr
BBI15_RS00620	COG3557	Belongs to the UPF0374 family
BBI15_RS00625	COG1132	(ABC) transporter
BBI15_RS00630	COG0444	Belongs to the ABC transporter superfamily
BBI15_RS00635	COG4608	Belongs to the ABC transporter superfamily
BBI15_RS00640	COG0747	negative chemotaxis
BBI15_RS00645	COG0601	transmembrane transport
BBI15_RS00650	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BBI15_RS00655	COG4129	membrane
BBI15_RS00665	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BBI15_RS00670	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BBI15_RS00680	COG0735	belongs to the Fur family
BBI15_RS00805	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BBI15_RS00820	COG3382	B3 4 domain protein
BBI15_RS00825	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BBI15_RS00830	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BBI15_RS00840	COG2252	PERMEase
BBI15_RS00845	COG0656	L-ascorbic acid biosynthetic process
BBI15_RS00850	COG0564	pseudouridine synthase activity
BBI15_RS00860	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
BBI15_RS00865	COG3153	acetyltransferase
BBI15_RS00865	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BBI15_RS00870	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BBI15_RS00875	COG4585	Histidine kinase
BBI15_RS00875	COG2203	Gaf domain
BBI15_RS00880	COG2197	response regulator
BBI15_RS00895	COG3264	Mechanosensitive ion channel
BBI15_RS00895	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
BBI15_RS00905	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BBI15_RS00910	COG1253	flavin adenine dinucleotide binding
BBI15_RS00920	COG3844	kynureninase activity
BBI15_RS00925	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
BBI15_RS00945	COG1132	(ABC) transporter
BBI15_RS00950	COG1132	(ABC) transporter
BBI15_RS00970	COG1024	Enoyl-CoA hydratase
BBI15_RS00980	COG4152	abc transporter atp-binding protein
BBI15_RS00985	COG1668	transmembrane transport
BBI15_RS00990	COG0420	3'-5' exonuclease activity
BBI15_RS01000	COG3481	metal-dependent phosphohydrolase, HD sub domain
BBI15_RS01005	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BBI15_RS01035	COG0537	adenosine 5'-monophosphoramidase activity
BBI15_RS01040	COG1131	(ABC) transporter
BBI15_RS01045	COG4473	ABC transporter
BBI15_RS01050	COG1473	amidohydrolase
BBI15_RS01055	COG0530	calcium, potassium:sodium antiporter activity
BBI15_RS01060	COG2329	Antibiotic biosynthesis monooxygenase
BBI15_RS01065	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BBI15_RS01070	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BBI15_RS01075	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
BBI15_RS01090	COG0095	Lipoate-protein ligase
BBI15_RS01095	COG0745	RESPONSE REGULATOR receiver
BBI15_RS01100	COG2205	protein histidine kinase activity
BBI15_RS01105	COG1136	(ABC) transporter
BBI15_RS01115	COG0318	PFAM AMP-dependent synthetase and ligase
BBI15_RS01120	COG1506	peptidase
BBI15_RS01120	COG0823	Involved in the tonB-independent uptake of proteins
BBI15_RS01120	COG4946	Tricorn protease homolog
BBI15_RS01125	COG1024	Enoyl-CoA hydratase
BBI15_RS01130	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BBI15_RS01150	COG0556	nucleotide-excision repair
BBI15_RS01155	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BBI15_RS01160	COG3595	metallopeptidase activity
BBI15_RS01170	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
BBI15_RS01180	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
BBI15_RS01190	COG0110	maltose O-acetyltransferase activity
BBI15_RS01205	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BBI15_RS01210	COG0131	Imidazoleglycerol-phosphate dehydratase
BBI15_RS01215	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BBI15_RS01220	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BBI15_RS01230	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BBI15_RS01230	COG0140	phosphoribosyl-ATP diphosphatase activity
BBI15_RS01235	COG0457	Tetratricopeptide repeat
BBI15_RS01240	COG0492	ferredoxin-NADP+ reductase activity
BBI15_RS01245	COG1051	belongs to the nudix hydrolase family
BBI15_RS01255	COG0391	Required for morphogenesis under gluconeogenic growth conditions
BBI15_RS01265	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BBI15_RS01270	COG0740	serine-type endopeptidase activity
BBI15_RS01280	COG1704	LemA family
BBI15_RS01295	COG2390	Transcriptional regulator
BBI15_RS01325	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BBI15_RS01330	COG1647	Serine aminopeptidase, S33
BBI15_RS01335	COG0557	exoribonuclease II activity
BBI15_RS01350	COG4974	Belongs to the 'phage' integrase family
BBI15_RS01380	COG1012	belongs to the aldehyde dehydrogenase family
BBI15_RS01385	COG4221	oxidoreductase activity
BBI15_RS01395	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BBI15_RS01400	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BBI15_RS01415	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BBI15_RS01420	COG1024	Enoyl-CoA hydratase
BBI15_RS01420	COG1250	3-hydroxyacyl-CoA dehydrogenase
BBI15_RS01425	COG0183	Belongs to the thiolase family
BBI15_RS01430	COG1960	acyl-CoA dehydrogenase activity
BBI15_RS01435	COG1393	Belongs to the ArsC family
BBI15_RS01445	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
BBI15_RS01450	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BBI15_RS01455	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BBI15_RS01465	COG1464	Belongs to the NlpA lipoprotein family
BBI15_RS01470	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
BBI15_RS01480	COG0396	ATPase activity
BBI15_RS01485	COG0719	Fe-S assembly protein
BBI15_RS01490	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BBI15_RS01495	COG0822	iron-sulfur transferase activity
BBI15_RS01500	COG0719	Fe-S assembly protein
BBI15_RS01515	COG0730	response to heat
BBI15_RS01530	COG0733	neurotransmitter:sodium symporter activity
BBI15_RS01535	COG4470	Protein conserved in bacteria
BBI15_RS01540	COG2445	Protein of unknown function DUF86
BBI15_RS01545	COG0647	UMP catabolic process
BBI15_RS01550	COG4844	belongs to the
BBI15_RS01555	COG1252	NADH dehydrogenase
BBI15_RS01560	COG4837	Protein of unknown function (DUF1462)
BBI15_RS01565	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
BBI15_RS01570	COG0316	Belongs to the HesB IscA family
BBI15_RS01575	COG1252	NADH dehydrogenase
BBI15_RS01590	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
BBI15_RS01595	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BBI15_RS01600	COG1320	monovalent cation:proton antiporter activity
BBI15_RS01605	COG2212	antiporter activity
BBI15_RS01610	COG1863	multisubunit Na H antiporter MnhE subunit
BBI15_RS01615	COG0651	ATP synthesis coupled electron transport
BBI15_RS01620	COG1006	Multisubunit Na H antiporter MnhC subunit
BBI15_RS01625	COG2111	Na H antiporter
BBI15_RS01635	COG2814	Major facilitator Superfamily
BBI15_RS01640	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BBI15_RS01645	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BBI15_RS01655	COG1396	sequence-specific DNA binding
BBI15_RS01660	COG0733	neurotransmitter:sodium symporter activity
BBI15_RS01670	COG1098	S1 RNA binding domain
BBI15_RS01675	COG3829	transcription factor binding
BBI15_RS01680	COG1012	belongs to the aldehyde dehydrogenase family
BBI15_RS01685	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BBI15_RS01695	COG1979	alcohol dehydrogenase
BBI15_RS01705	COG1285	pathogenesis
BBI15_RS01825	COG0697	spore germination
BBI15_RS01830	COG1575	Belongs to the MenA family. Type 1 subfamily
BBI15_RS01835	COG1169	isochorismate synthase
BBI15_RS01845	COG0596	Alpha beta hydrolase
BBI15_RS01850	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
BBI15_RS01855	COG0318	PFAM AMP-dependent synthetase and ligase
BBI15_RS01860	COG4948	Mandelate Racemase Muconate Lactonizing
BBI15_RS01865	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
BBI15_RS01870	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BBI15_RS01875	COG0783	Belongs to the Dps family
BBI15_RS01880	COG0494	nUDIX hydrolase
BBI15_RS01885	COG1506	peptidase
BBI15_RS01900	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BBI15_RS01905	COG2267	carboxylic ester hydrolase activity
BBI15_RS01915	COG0028	Belongs to the TPP enzyme family
BBI15_RS01920	COG0604	alcohol dehydrogenase
BBI15_RS01925	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
BBI15_RS01930	COG1242	4 iron, 4 sulfur cluster binding
BBI15_RS01935	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
BBI15_RS01940	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
BBI15_RS01950	COG2081	HI0933 family
BBI15_RS01955	COG2244	polysaccharide biosynthetic process
BBI15_RS01960	COG1187	pseudouridine synthase activity
BBI15_RS01965	COG1349	DNA-binding transcription factor activity
BBI15_RS01970	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BBI15_RS01995	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BBI15_RS02005	COG1363	Peptidase, m42
BBI15_RS02010	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
BBI15_RS02020	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BBI15_RS02025	COG4848	Belongs to the UPF0354 family
BBI15_RS02030	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BBI15_RS02035	COG1674	ftsk spoiiie
BBI15_RS02045	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
BBI15_RS02060	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
BBI15_RS02060	COG1605	Chorismate mutase
BBI15_RS02070	COG0123	including yeast histone deacetylase and acetoin utilization protein
BBI15_RS02075	COG0517	IMP dehydrogenase activity
BBI15_RS02080	COG0454	-acetyltransferase
BBI15_RS02085	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BBI15_RS02125	COG1956	GAF domain-containing protein
BBI15_RS02130	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BBI15_RS02135	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
BBI15_RS02140	COG1104	cysteine desulfurase activity
BBI15_RS02150	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BBI15_RS02155	COG2962	Rard protein
BBI15_RS02160	COG0616	signal peptide processing
BBI15_RS02165	COG1714	RDD family
BBI15_RS02170	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
BBI15_RS02175	COG0827	DNA restriction-modification system
BBI15_RS02180	COG0589	response to stress
BBI15_RS02185	COG2824	Alkylphosphonate utilization operon protein PhnA
BBI15_RS02195	COG0720	synthase
BBI15_RS02200	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BBI15_RS02205	COG0604	alcohol dehydrogenase
BBI15_RS02205	COG3321	synthase
BBI15_RS02205	COG4221	oxidoreductase activity
BBI15_RS02205	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BBI15_RS02210	COG0589	response to stress
BBI15_RS02220	COG0006	proline dipeptidase activity
BBI15_RS02225	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BBI15_RS02230	COG4109	DRTGG domain
BBI15_RS02240	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
BBI15_RS02245	COG0587	DNA-directed DNA polymerase activity
BBI15_RS02250	COG2186	Transcriptional regulator
BBI15_RS02260	COG0825	malonyl-CoA metabolic process
BBI15_RS02280	COG0372	Belongs to the citrate synthase family
BBI15_RS02285	COG0538	isocitrate dehydrogenase activity
BBI15_RS02290	COG0039	L-malate dehydrogenase activity
BBI15_RS02300	COG0745	RESPONSE REGULATOR receiver
BBI15_RS02305	COG5002	protein histidine kinase activity
BBI15_RS02320	COG0330	HflC and HflK could
BBI15_RS02325	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BBI15_RS02325	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BBI15_RS02330	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BBI15_RS02340	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BBI15_RS02345	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
BBI15_RS02355	COG3611	Membrane attachment protein
BBI15_RS02360	COG1484	DNA-dependent DNA replication
BBI15_RS02365	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BBI15_RS02370	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BBI15_RS02375	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BBI15_RS02400	COG1363	Peptidase, m42
BBI15_RS02410	COG1476	TRANSCRIPTIONal
BBI15_RS02425	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BBI15_RS02435	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BBI15_RS02435	COG0072	phenylalanine-tRNA ligase activity
BBI15_RS02450	COG1286	toxin biosynthetic process
BBI15_RS02455	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BBI15_RS02455	COG1796	DNA polymerase
BBI15_RS02460	COG1193	negative regulation of DNA recombination
BBI15_RS02465	COG3766	membrane
BBI15_RS02470	COG0318	PFAM AMP-dependent synthetase and ligase
BBI15_RS02475	COG1309	transcriptional regulator
BBI15_RS02480	COG1024	Enoyl-CoA hydratase
BBI15_RS02485	COG2086	electron transfer activity
BBI15_RS02490	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
BBI15_RS02495	COG3118	belongs to the thioredoxin family
BBI15_RS02510	COG2009	succinate dehydrogenase
BBI15_RS02515	COG1053	succinate dehydrogenase
BBI15_RS02520	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BBI15_RS02525	COG0824	Thioesterase
BBI15_RS02530	COG1846	Transcriptional regulator
BBI15_RS02565	COG1477	protein flavinylation
BBI15_RS02565	COG0457	Tetratricopeptide repeat
BBI15_RS02570	COG0544	peptidyl-prolyl cis-trans isomerase activity
BBI15_RS02585	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BBI15_RS02595	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BBI15_RS02610	COG0113	porphobilinogen synthase activity
BBI15_RS02620	COG3180	Ammonia monooxygenase
BBI15_RS02625	COG0525	valine-tRNA ligase activity
BBI15_RS02630	COG0189	ligase activity
BBI15_RS02635	COG0189	ligase activity
BBI15_RS02645	COG2203	Gaf domain
BBI15_RS02645	COG2199	diguanylate cyclase activity
BBI15_RS02675	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BBI15_RS02685	COG1459	type II secretion system
BBI15_RS02710	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BBI15_RS02715	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
BBI15_RS02720	COG0424	maF-like protein
BBI15_RS02725	COG2003	Belongs to the UPF0758 family
BBI15_RS02730	COG1077	Cell shape determining protein MreB Mrl
BBI15_RS02735	COG1792	Involved in formation and maintenance of cell shape
BBI15_RS02745	COG0850	regulation of cytokinetic process
BBI15_RS02750	COG2894	cell division
BBI15_RS02760	COG2868	ribosomal protein
BBI15_RS02765	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BBI15_RS02785	COG0077	Prephenate dehydratase
BBI15_RS02790	COG1827	regulation of RNA biosynthetic process
BBI15_RS02815	COG1862	Preprotein translocase
BBI15_RS02825	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BBI15_RS02825	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BBI15_RS02830	COG5416	Lipopolysaccharide assembly protein A domain
BBI15_RS02835	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BBI15_RS02835	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
BBI15_RS02840	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BBI15_RS02845	COG5434	Belongs to the glycosyl hydrolase 28 family
BBI15_RS02850	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BBI15_RS02860	COG4991	sh3 domain protein
BBI15_RS02860	COG0860	N-Acetylmuramoyl-L-alanine amidase
BBI15_RS02860	COG3103	Sh3 type 3 domain protein
BBI15_RS02870	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BBI15_RS02880	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BBI15_RS02885	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BBI15_RS02890	COG1959	2 iron, 2 sulfur cluster binding
BBI15_RS02895	COG1104	cysteine desulfurase activity
BBI15_RS02900	COG0482	sulfurtransferase activity
BBI15_RS02910	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BBI15_RS02920	COG4472	Bacterial protein of unknown function (DUF965)
BBI15_RS02930	COG3906	Belongs to the UPF0473 family
BBI15_RS02935	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BBI15_RS02940	COG4122	O-methyltransferase activity
BBI15_RS02945	COG0572	uridine kinase
BBI15_RS02950	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BBI15_RS02965	COG1183	phosphatidylcholine synthase activity
BBI15_RS02970	COG0688	phosphatidylethanolamine metabolic process
BBI15_RS02975	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
BBI15_RS02980	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
BBI15_RS02990	COG1534	Rna-binding protein
BBI15_RS02995	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BBI15_RS03000	COG1713	HD superfamily hydrolase involved in NAD metabolism
BBI15_RS03005	COG0799	negative regulation of ribosome biogenesis
BBI15_RS03010	COG2226	methyltransferase
BBI15_RS03015	COG1596	polysaccharide export
BBI15_RS03015	COG1555	photosystem II stabilization
BBI15_RS03020	COG2131	deaminase
BBI15_RS03025	COG0658	competence protein
BBI15_RS03025	COG2333	competence protein COMEC
BBI15_RS03030	COG1466	dna polymerase III delta subunit
BBI15_RS03040	COG0481	GTPase activity
BBI15_RS03045	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BBI15_RS03055	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BBI15_RS03060	COG0443	Heat shock 70 kDa protein
BBI15_RS03070	COG2264	protein methyltransferase activity
BBI15_RS03075	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BBI15_RS03080	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BBI15_RS03085	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
BBI15_RS03090	COG0828	Belongs to the bacterial ribosomal protein bS21 family
BBI15_RS03095	COG1030	water channel activity
BBI15_RS03100	COG4864	UPF0365 protein
BBI15_RS03110	COG1702	phosphate starvation-inducible protein PhoH
BBI15_RS03115	COG1480	7TM receptor with intracellular HD hydrolase
BBI15_RS03125	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BBI15_RS03140	COG1381	Involved in DNA repair and RecF pathway recombination
BBI15_RS03150	COG0517	IMP dehydrogenase activity
BBI15_RS03160	COG0358	DNA primase activity
BBI15_RS03165	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BBI15_RS03170	COG1960	acyl-CoA dehydrogenase activity
BBI15_RS03180	COG2384	SAM-dependent methyltransferase
BBI15_RS03185	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BBI15_RS03195	COG0513	Belongs to the DEAD box helicase family
BBI15_RS03205	COG1121	(ABC) transporter
BBI15_RS03210	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BBI15_RS03215	COG0735	belongs to the Fur family
BBI15_RS03220	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
BBI15_RS03225	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BBI15_RS03235	COG1283	sodium-dependent phosphate transmembrane transporter activity
BBI15_RS03250	COG0768	penicillin binding
BBI15_RS03255	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BBI15_RS03260	COG0573	inorganic phosphate transmembrane transporter activity
BBI15_RS03265	COG0581	inorganic phosphate transmembrane transporter activity
BBI15_RS03270	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BBI15_RS03275	COG0704	Plays a role in the regulation of phosphate uptake
BBI15_RS03280	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BBI15_RS03285	COG4483	Protein conserved in bacteria
BBI15_RS03290	COG1368	sulfuric ester hydrolase activity
BBI15_RS03300	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BBI15_RS03310	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BBI15_RS03315	COG1459	type II secretion system
BBI15_RS03345	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BBI15_RS03350	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BBI15_RS03365	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BBI15_RS03370	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BBI15_RS03375	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BBI15_RS03380	COG0006	proline dipeptidase activity
BBI15_RS03385	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BBI15_RS03390	COG0511	ligase activity, forming carbon-carbon bonds
BBI15_RS03395	COG0439	Biotin carboxylase
BBI15_RS03400	COG1302	Protein conserved in bacteria
BBI15_RS03410	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BBI15_RS03425	COG0142	geranyltranstransferase activity
BBI15_RS03430	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BBI15_RS03435	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
BBI15_RS03440	COG1438	arginine binding
BBI15_RS03445	COG0497	DNA recombination
BBI15_RS03455	COG0584	glycerophosphoryl diester phosphodiesterase
BBI15_RS03465	COG3829	transcription factor binding
BBI15_RS03465	COG3290	protein histidine kinase activity
BBI15_RS03470	COG0280	phosphate acetyltransferase
BBI15_RS03480	COG3426	butyrate kinase activity
BBI15_RS03485	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BBI15_RS03490	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BBI15_RS03495	COG0022	dehydrogenase e1 component
BBI15_RS03500	COG0508	dehydrogenase complex catalyzes the overall conversion of
BBI15_RS03505	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BBI15_RS03510	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BBI15_RS03510	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BBI15_RS03525	COG4129	membrane
BBI15_RS03530	COG0346	lactoylglutathione lyase activity
BBI15_RS03535	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BBI15_RS03540	COG2195	Cleaves the N-terminal amino acid of tripeptides
BBI15_RS03545	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BBI15_RS03550	COG1234	tRNA 3'-trailer cleavage
BBI15_RS03565	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BBI15_RS03625	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BBI15_RS03635	COG0789	Transcriptional regulator
BBI15_RS03640	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BBI15_RS03650	COG2133	pyrroloquinoline quinone binding
BBI15_RS03680	COG0778	Nitroreductase
BBI15_RS03685	COG1846	Transcriptional regulator
BBI15_RS03690	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
BBI15_RS03695	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BBI15_RS03700	COG0011	TIGRFAM Protein of
BBI15_RS03705	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BBI15_RS03720	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BBI15_RS03725	COG1737	Transcriptional regulator
BBI15_RS03730	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
BBI15_RS03735	COG2610	gluconate transmembrane transporter activity
BBI15_RS03740	COG1070	Carbohydrate kinase
BBI15_RS03750	COG0494	nUDIX hydrolase
BBI15_RS03760	COG2304	oxidoreductase activity
BBI15_RS03790	COG0398	Pfam SNARE associated Golgi protein
BBI15_RS03810	COG3842	ATPase activity
BBI15_RS03815	COG1902	pentaerythritol trinitrate reductase activity
BBI15_RS03820	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BBI15_RS03825	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BBI15_RS03835	COG0137	argininosuccinate synthase activity
BBI15_RS03840	COG0165	Argininosuccinate lyase
BBI15_RS03845	COG0785	Cytochrome C biogenesis protein
BBI15_RS03850	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BBI15_RS03855	COG4846	Membrane protein involved in cytochrome C biogenesis
BBI15_RS03875	COG1999	signal sequence binding
BBI15_RS03895	COG1335	isochorismatase
BBI15_RS03910	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BBI15_RS03915	COG0824	Thioesterase
BBI15_RS03925	COG4841	protein insertion into membrane
BBI15_RS03930	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BBI15_RS03935	COG1832	CoA-binding protein
BBI15_RS03940	COG0187	DNA topoisomerase II activity
BBI15_RS03945	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BBI15_RS03950	COG0318	PFAM AMP-dependent synthetase and ligase
BBI15_RS03965	COG2391	methyltransferase activity
BBI15_RS03975	COG0697	spore germination
BBI15_RS03980	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BBI15_RS04005	COG0406	alpha-ribazole phosphatase activity
BBI15_RS04030	COG1105	Belongs to the carbohydrate kinase PfkB family
BBI15_RS04035	COG1349	DNA-binding transcription factor activity
BBI15_RS04045	COG0300	oxidoreductase activity
BBI15_RS04060	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BBI15_RS04065	COG3258	Cytochrome c
BBI15_RS04080	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BBI15_RS04135	COG0071	Belongs to the small heat shock protein (HSP20) family
BBI15_RS04145	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
BBI15_RS04165	COG1473	amidohydrolase
BBI15_RS04175	COG0372	Belongs to the citrate synthase family
BBI15_RS04180	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
BBI15_RS04195	COG0628	permease
BBI15_RS04205	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BBI15_RS04215	COG2807	transmembrane transport
BBI15_RS04225	COG0488	(ABC) transporter
BBI15_RS04235	COG1278	Cold shock
BBI15_RS04240	COG1278	Cold shock
BBI15_RS04250	COG3853	Toxic anion resistance protein (TelA)
BBI15_RS04255	COG4548	von Willebrand factor, type A
BBI15_RS04260	COG0714	Associated with various cellular activities
BBI15_RS04280	COG0567	Dehydrogenase, E1 component
BBI15_RS04285	COG3447	MASE1 domain protein
BBI15_RS04285	COG5002	protein histidine kinase activity
BBI15_RS04285	COG5001	Diguanylate cyclase
BBI15_RS04290	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BBI15_RS04310	COG0523	cobalamin synthesis protein
BBI15_RS04315	COG3409	Peptidoglycan-binding domain 1 protein
BBI15_RS04315	COG0793	Belongs to the peptidase S41A family
BBI15_RS04320	COG0813	purine-nucleoside phosphorylase activity
BBI15_RS04325	COG4479	Belongs to the UPF0346 family
BBI15_RS04345	COG2755	lipolytic protein G-D-S-L family
BBI15_RS04350	COG1307	EDD domain protein, DegV family
BBI15_RS04360	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BBI15_RS04375	COG2521	methyltransferase
BBI15_RS04375	COG2136	Putative SAM-dependent methyltransferase
BBI15_RS04400	COG1413	lyase activity
BBI15_RS04405	COG0488	(ABC) transporter
BBI15_RS04410	COG1418	mRNA catabolic process
BBI15_RS04425	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BBI15_RS04445	COG2133	pyrroloquinoline quinone binding
BBI15_RS04465	COG0702	epimerase
BBI15_RS04480	COG1028	Short-chain dehydrogenase reductase Sdr
BBI15_RS04485	COG1574	metal-dependent hydrolase with the TIM-barrel fold
BBI15_RS04490	COG1253	flavin adenine dinucleotide binding
BBI15_RS04500	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
BBI15_RS04505	COG1028	Short-chain dehydrogenase reductase Sdr
BBI15_RS04510	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
BBI15_RS04515	COG1199	ATP-dependent helicase activity
BBI15_RS04520	COG0116	Belongs to the methyltransferase superfamily
BBI15_RS04535	COG3599	regulation of cell shape
BBI15_RS04540	COG3359	exonuclease
BBI15_RS04545	COG1111	helicase
BBI15_RS04545	COG1205	dead DEAH box helicase
BBI15_RS04560	COG4499	WXG100 protein secretion system (Wss), protein YukC
BBI15_RS04560	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BBI15_RS04570	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BBI15_RS04575	COG3935	DnaD domain protein
BBI15_RS04600	COG1199	ATP-dependent helicase activity
BBI15_RS04600	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BBI15_RS04605	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
BBI15_RS04625	COG0438	transferase activity, transferring glycosyl groups
BBI15_RS04640	COG1694	Mazg nucleotide pyrophosphohydrolase
BBI15_RS04645	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BBI15_RS04650	COG2738	Putative neutral zinc metallopeptidase
BBI15_RS04655	COG4347	Protein of unknown function (DUF1405)
BBI15_RS04670	COG0723	plastoquinol--plastocyanin reductase activity
BBI15_RS04685	COG0457	Tetratricopeptide repeat
BBI15_RS04695	COG0287	Prephenate dehydrogenase
BBI15_RS04700	COG4401	Chorismate mutase type I
BBI15_RS04715	COG0105	UTP biosynthetic process
BBI15_RS04720	COG0142	geranyltranstransferase activity
BBI15_RS04730	COG0142	geranyltranstransferase activity
BBI15_RS04770	COG1304	FMN binding
BBI15_RS04775	COG0539	negative regulation of cytoplasmic translation
BBI15_RS04780	COG0204	Acyl-transferase
BBI15_RS04790	COG2339	peptidase activity
BBI15_RS04800	COG0492	ferredoxin-NADP+ reductase activity
BBI15_RS04805	COG1408	metallophosphoesterase
BBI15_RS04815	COG1388	LysM domain
BBI15_RS04820	COG0514	ATP-dependent DNA helicase (RecQ)
BBI15_RS04825	COG4955	Helix-turn-helix domain
BBI15_RS04830	COG1141	Ferredoxin
BBI15_RS04835	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
BBI15_RS04845	COG1595	DNA-templated transcription, initiation
BBI15_RS04850	COG5002	protein histidine kinase activity
BBI15_RS04855	COG0745	RESPONSE REGULATOR receiver
BBI15_RS04860	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BBI15_RS04865	COG1333	cytochrome c biogenesis protein
BBI15_RS04870	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BBI15_RS04875	COG1187	pseudouridine synthase activity
BBI15_RS04880	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BBI15_RS04890	COG1547	Domain of unknown function (DUF309)
BBI15_RS04900	COG0019	diaminopimelate decarboxylase activity
BBI15_RS04915	COG4974	Belongs to the 'phage' integrase family
BBI15_RS04920	COG0735	belongs to the Fur family
BBI15_RS04925	COG0494	nUDIX hydrolase
BBI15_RS04930	COG0667	Aldo Keto reductase
BBI15_RS04940	COG2268	Band 7 protein
BBI15_RS04955	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BBI15_RS04960	COG1073	alpha beta
BBI15_RS04965	COG3763	UPF0154 protein
BBI15_RS04980	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BBI15_RS04985	COG1388	LysM domain
BBI15_RS05005	COG0174	glutamine synthetase
BBI15_RS05010	COG0789	Transcriptional regulator
BBI15_RS05015	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
BBI15_RS05020	COG2860	membrane
BBI15_RS05025	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BBI15_RS05030	COG1923	regulation of RNA biosynthetic process
BBI15_RS05055	COG4550	Control of competence regulator ComK, YlbF/YmcA
BBI15_RS05060	COG1692	metallophosphoesterase
BBI15_RS05070	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BBI15_RS05080	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BBI15_RS05085	COG1426	Protein conserved in bacteria
BBI15_RS05100	COG0612	Peptidase, M16
BBI15_RS05105	COG0612	Peptidase, M16
BBI15_RS05110	COG1079	Belongs to the binding-protein-dependent transport system permease family
BBI15_RS05115	COG4603	Belongs to the binding-protein-dependent transport system permease family
BBI15_RS05120	COG3845	ABC transporter
BBI15_RS05125	COG1744	ABC transporter substrate-binding protein PnrA-like
BBI15_RS05130	COG2188	Transcriptional regulator
BBI15_RS05135	COG1674	ftsk spoiiie
BBI15_RS05140	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BBI15_RS05145	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BBI15_RS05150	COG0612	Peptidase, M16
BBI15_RS05160	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BBI15_RS05165	COG0196	riboflavin kinase activity
BBI15_RS05175	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BBI15_RS05180	COG1550	Protein conserved in bacteria
BBI15_RS05190	COG1358	cellular component organization or biogenesis
BBI15_RS05195	COG2740	Nucleic-acid-binding protein implicated in transcription termination
BBI15_RS05200	COG0195	Participates in both transcription termination and antitermination
BBI15_RS05210	COG2176	DNA-directed DNA polymerase activity
BBI15_RS05220	COG0750	zinc metalloprotease
BBI15_RS05230	COG4589	Belongs to the CDS family
BBI15_RS05235	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BBI15_RS05240	COG0233	cytoplasmic translational termination
BBI15_RS05245	COG0528	UMP kinase activity
BBI15_RS05260	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
BBI15_RS05265	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
BBI15_RS05270	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
BBI15_RS05275	COG4974	Belongs to the 'phage' integrase family
BBI15_RS05285	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BBI15_RS05290	COG0758	DNA mediated transformation
BBI15_RS05300	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BBI15_RS05310	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BBI15_RS05315	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
BBI15_RS05330	COG0336	Belongs to the RNA methyltransferase TrmD family
BBI15_RS05335	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BBI15_RS05340	COG1837	Belongs to the UPF0109 family
BBI15_RS05350	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BBI15_RS05355	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
BBI15_RS05360	COG0552	protein localization to endoplasmic reticulum
BBI15_RS05370	COG0571	ribonuclease III activity
BBI15_RS05375	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BBI15_RS05380	COG1028	Short-chain dehydrogenase reductase Sdr
BBI15_RS05385	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BBI15_RS05395	COG1349	DNA-binding transcription factor activity
BBI15_RS05395	COG2050	protein possibly involved in aromatic compounds catabolism
BBI15_RS05400	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BBI15_RS05405	COG1760	l-serine dehydratase
BBI15_RS05410	COG1760	l-serine dehydratase
BBI15_RS05415	COG1461	Dihydroxyacetone kinase
BBI15_RS05420	COG1302	Protein conserved in bacteria
BBI15_RS05425	COG1564	THIamine pyrophosphokinase
BBI15_RS05430	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BBI15_RS05435	COG1162	GTPase activity
BBI15_RS05440	COG2815	serine threonine protein kinase
BBI15_RS05440	COG0515	serine threonine protein kinase
BBI15_RS05445	COG0631	protein serine/threonine phosphatase activity
BBI15_RS05450	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BBI15_RS05450	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BBI15_RS05465	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BBI15_RS05470	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BBI15_RS05480	COG0194	GDP metabolic process
BBI15_RS05485	COG2052	Domain of unknown function (DUF370)
BBI15_RS05490	COG1293	RNA-binding protein homologous to eukaryotic snRNP
BBI15_RS05495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BBI15_RS05500	COG0765	amino acid transport
BBI15_RS05515	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BBI15_RS05525	COG0167	dihydroorotate dehydrogenase activity
BBI15_RS05540	COG0505	Belongs to the CarA family
BBI15_RS05545	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BBI15_RS05560	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
BBI15_RS05565	COG0564	pseudouridine synthase activity
BBI15_RS05570	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BBI15_RS05575	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BBI15_RS05580	COG3599	regulation of cell shape
BBI15_RS05585	COG2302	S4 RNA-binding domain
BBI15_RS05590	COG0762	integral membrane protein
BBI15_RS05595	COG1799	cell septum assembly
BBI15_RS05600	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BBI15_RS05605	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BBI15_RS05610	COG0849	cell division
BBI15_RS05615	COG3856	small basic protein
BBI15_RS05620	COG3879	Bacterial protein of unknown function (DUF881)
BBI15_RS05625	COG3879	Bacterial protein of unknown function (DUF881)
BBI15_RS05630	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BBI15_RS05635	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BBI15_RS05645	COG0768	penicillin binding
BBI15_RS05660	COG2001	Belongs to the MraZ family
BBI15_RS05675	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BBI15_RS05680	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BBI15_RS05685	COG0511	ligase activity, forming carbon-carbon bonds
BBI15_RS05690	COG0439	Biotin carboxylase
BBI15_RS05695	COG1024	Enoyl-CoA hydratase
BBI15_RS05700	COG1399	metal-binding, possibly nucleic acid-binding protein
BBI15_RS05710	COG3480	Lon protease (S16) C-terminal proteolytic domain
BBI15_RS05715	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BBI15_RS05720	COG0742	ribosomal rna small subunit methyltransferase
BBI15_RS05730	COG4471	UPF0298 protein
BBI15_RS05735	COG0584	glycerophosphoryl diester phosphodiesterase
BBI15_RS05740	COG3679	Belongs to the UPF0342 family
BBI15_RS05745	COG2340	Cysteine-rich secretory protein family
BBI15_RS05765	COG3336	cytochrome c oxidase
BBI15_RS05770	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BBI15_RS05800	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
BBI15_RS05805	COG0772	Belongs to the SEDS family
BBI15_RS05815	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BBI15_RS05820	COG4896	Protein conserved in bacteria
BBI15_RS05835	COG1217	gtp-binding protein TYPA
BBI15_RS05845	COG0483	inositol monophosphate 1-phosphatase activity
BBI15_RS05870	COG1982	Orn Lys Arg decarboxylase major
BBI15_RS05875	COG0726	polysaccharide deacetylase
BBI15_RS05885	COG0508	dehydrogenase complex catalyzes the overall conversion of
BBI15_RS05890	COG0022	dehydrogenase e1 component
BBI15_RS05910	COG0561	phosphatase activity
BBI15_RS05920	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BBI15_RS05925	COG0569	domain protein
BBI15_RS05940	COG3842	ATPase activity
BBI15_RS05945	COG1176	ABC-type spermidine putrescine transport system, permease component I
BBI15_RS05950	COG1177	transmembrane transport
BBI15_RS05955	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
BBI15_RS05960	COG2814	Major facilitator Superfamily
BBI15_RS05965	COG1473	amidohydrolase
BBI15_RS05970	COG2171	N-acyltransferase activity
BBI15_RS05975	COG0583	DNA-binding transcription factor activity
BBI15_RS05980	COG0477	Major facilitator Superfamily
BBI15_RS05985	COG0517	IMP dehydrogenase activity
BBI15_RS05990	COG1028	Short-chain dehydrogenase reductase Sdr
BBI15_RS06000	COG2084	Dehydrogenase
BBI15_RS06025	COG1846	Transcriptional regulator
BBI15_RS06030	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BBI15_RS06040	COG1191	sigma factor activity
BBI15_RS06045	COG0861	Integral membrane protein TerC family
BBI15_RS06060	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
BBI15_RS06065	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BBI15_RS06070	COG1363	Peptidase, m42
BBI15_RS06075	COG4191	Histidine kinase
BBI15_RS06090	COG5002	protein histidine kinase activity
BBI15_RS06090	COG3850	Histidine kinase
BBI15_RS06095	COG0745	RESPONSE REGULATOR receiver
BBI15_RS06105	COG0673	inositol 2-dehydrogenase activity
BBI15_RS06110	COG1525	nuclease
BBI15_RS06135	COG2358	TRAP transporter, solute receptor (TAXI family
BBI15_RS06140	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BBI15_RS06145	COG2382	esterase
BBI15_RS06150	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
BBI15_RS06160	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BBI15_RS06165	COG2239	Acts as a magnesium transporter
BBI15_RS06170	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BBI15_RS06175	COG0564	pseudouridine synthase activity
BBI15_RS06185	COG2357	RelA SpoT domain protein
BBI15_RS06190	COG4116	CYTH
BBI15_RS06195	COG2346	COG2346, Truncated hemoglobins
BBI15_RS06200	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BBI15_RS06205	COG1164	Oligoendopeptidase f
BBI15_RS06215	COG4862	establishment of competence for transformation
BBI15_RS06220	COG1393	Belongs to the ArsC family
BBI15_RS06230	COG4608	Belongs to the ABC transporter superfamily
BBI15_RS06235	COG0444	Belongs to the ABC transporter superfamily
BBI15_RS06240	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BBI15_RS06245	COG0601	transmembrane transport
BBI15_RS06260	COG0180	Tryptophanyl-tRNA synthetase
BBI15_RS06265	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BBI15_RS06270	COG0601	transmembrane transport
BBI15_RS06280	COG4608	Belongs to the ABC transporter superfamily
BBI15_RS06290	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BBI15_RS06310	COG2151	metal-sulfur cluster biosynthetic enzyme
BBI15_RS06315	COG1073	alpha beta
BBI15_RS06320	COG0561	phosphatase activity
BBI15_RS06325	COG1307	EDD domain protein, DegV family
BBI15_RS06345	COG0179	Fumarylacetoacetate (FAA) hydrolase
BBI15_RS06350	COG2311	Membrane
BBI15_RS06365	COG0398	Pfam SNARE associated Golgi protein
BBI15_RS06370	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
BBI15_RS06380	COG4897	Protein conserved in bacteria
BBI15_RS06385	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BBI15_RS06390	COG0626	cystathionine gamma-synthase activity
BBI15_RS06395	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BBI15_RS06400	COG0739	heme binding
BBI15_RS06405	COG2177	Part of the ABC transporter FtsEX involved in
BBI15_RS06410	COG2884	Cell division ATP-binding protein ftsE
BBI15_RS06420	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BBI15_RS06430	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BBI15_RS06435	COG0653	protein targeting
BBI15_RS06440	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BBI15_RS06445	COG1028	Short-chain dehydrogenase reductase Sdr
BBI15_RS06450	COG1040	competence protein
BBI15_RS06455	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
BBI15_RS06460	COG1307	EDD domain protein, DegV family
BBI15_RS06470	COG2176	DNA-directed DNA polymerase activity
BBI15_RS06475	COG2197	response regulator
BBI15_RS06480	COG4585	Histidine kinase
BBI15_RS06485	COG1739	Uncharacterized protein family UPF0029
BBI15_RS06490	COG1316	TRANSCRIPTIONal
BBI15_RS06495	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BBI15_RS06510	COG1114	Component of the transport system for branched-chain amino acids
BBI15_RS06535	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
BBI15_RS06570	COG1473	amidohydrolase
BBI15_RS06580	COG1012	belongs to the aldehyde dehydrogenase family
BBI15_RS06585	COG0083	homoserine kinase activity
BBI15_RS06590	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BBI15_RS06595	COG0460	homoserine dehydrogenase
BBI15_RS06600	COG0527	aspartate kinase activity
BBI15_RS06605	COG4297	protein containing double-stranded beta helix domain
BBI15_RS06610	COG4187	Peptidase family M20/M25/M40
BBI15_RS06615	COG0436	Aminotransferase
BBI15_RS06620	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BBI15_RS06620	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BBI15_RS06630	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BBI15_RS06635	COG1802	Transcriptional regulator
BBI15_RS06640	COG0277	FAD linked oxidase domain protein
BBI15_RS06645	COG1388	LysM domain
BBI15_RS06645	COG0791	NLP P60 protein
BBI15_RS06665	COG2224	Isocitrate lyase
BBI15_RS06670	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
BBI15_RS06700	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
BBI15_RS06705	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BBI15_RS06710	COG0765	amino acid transport
BBI15_RS06715	COG1126	abc transporter atp-binding protein
BBI15_RS06735	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BBI15_RS06765	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
BBI15_RS06770	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BBI15_RS06775	COG0640	Transcriptional regulator
BBI15_RS06805	COG0626	cystathionine gamma-synthase activity
BBI15_RS06810	COG0626	cystathionine gamma-synthase activity
BBI15_RS06815	COG0281	malic enzyme
BBI15_RS06820	COG1250	3-hydroxyacyl-CoA dehydrogenase
BBI15_RS06850	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BBI15_RS06865	COG0489	protein tyrosine kinase activity
BBI15_RS06870	COG3944	biosynthesis protein
BBI15_RS06880	COG0745	RESPONSE REGULATOR receiver
BBI15_RS06885	COG5002	protein histidine kinase activity
BBI15_RS06890	COG5001	Diguanylate cyclase
BBI15_RS06935	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
BBI15_RS06945	COG5298	Protein conserved in bacteria
BBI15_RS06950	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
BBI15_RS06970	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BBI15_RS06980	COG3764	Sortase (surface protein transpeptidase)
BBI15_RS06985	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BBI15_RS06995	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
BBI15_RS07005	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BBI15_RS07010	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BBI15_RS07015	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BBI15_RS07020	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
BBI15_RS07025	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BBI15_RS07035	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BBI15_RS07070	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BBI15_RS07085	COG0728	peptidoglycan biosynthetic process
BBI15_RS07105	COG2329	Antibiotic biosynthesis monooxygenase
BBI15_RS07165	COG1522	sequence-specific DNA binding
BBI15_RS07170	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BBI15_RS07185	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BBI15_RS07190	COG1368	sulfuric ester hydrolase activity
BBI15_RS07200	COG3706	GGDEF domain
BBI15_RS07235	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BBI15_RS07260	COG0686	Belongs to the AlaDH PNT family
BBI15_RS07270	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
BBI15_RS07275	COG0363	glucosamine-6-phosphate deaminase activity
BBI15_RS07280	COG1393	Belongs to the ArsC family
BBI15_RS07300	COG0246	Mannitol dehydrogenase
BBI15_RS07305	COG3711	transcriptional antiterminator
BBI15_RS07310	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
BBI15_RS07310	COG2213	PTS system mannitol-specific
BBI15_RS07315	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BBI15_RS07355	COG1115	amino acid carrier protein
BBI15_RS07435	COG1131	(ABC) transporter
BBI15_RS07445	COG1131	(ABC) transporter
BBI15_RS07470	COG0765	amino acid transport
BBI15_RS07475	COG0765	amino acid transport
BBI15_RS07480	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BBI15_RS07485	COG1126	abc transporter atp-binding protein
BBI15_RS07505	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BBI15_RS07510	COG0110	maltose O-acetyltransferase activity
BBI15_RS07515	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BBI15_RS07520	COG0438	transferase activity, transferring glycosyl groups
BBI15_RS07565	COG0489	protein tyrosine kinase activity
BBI15_RS07570	COG3944	biosynthesis protein
BBI15_RS07580	COG1316	TRANSCRIPTIONal
BBI15_RS07600	COG1088	dTDP-glucose 4,6-dehydratase activity
BBI15_RS07610	COG0737	Belongs to the 5'-nucleotidase family
BBI15_RS07630	COG3621	Patatin-like phospholipase
BBI15_RS07635	COG0791	NLP P60 protein
BBI15_RS07635	COG1388	LysM domain
BBI15_RS07680	COG0596	Alpha beta hydrolase
BBI15_RS07700	COG0745	RESPONSE REGULATOR receiver
BBI15_RS07705	COG5002	protein histidine kinase activity
BBI15_RS07710	COG1388	LysM domain
BBI15_RS07750	COG2364	Membrane
BBI15_RS07755	COG1846	Transcriptional regulator
BBI15_RS07760	COG0456	acetyltransferase
BBI15_RS07770	COG2076	Multidrug Resistance protein
BBI15_RS07775	COG2076	Multidrug Resistance protein
BBI15_RS07780	COG1250	3-hydroxyacyl-CoA dehydrogenase
BBI15_RS07795	COG1621	beta-fructofuranosidase activity
BBI15_RS07825	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BBI15_RS07860	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BBI15_RS07870	COG1366	Belongs to the anti-sigma-factor antagonist family
BBI15_RS07880	COG2226	methyltransferase
BBI15_RS07905	COG0352	thiamine-phosphate diphosphorylase activity
BBI15_RS07910	COG0351	phosphomethylpyrimidine kinase
BBI15_RS07915	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
BBI15_RS07920	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
BBI15_RS07940	COG0728	peptidoglycan biosynthetic process
BBI15_RS07945	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BBI15_RS07965	COG0737	Belongs to the 5'-nucleotidase family
BBI15_RS07980	COG0860	N-Acetylmuramoyl-L-alanine amidase
BBI15_RS07985	COG1368	sulfuric ester hydrolase activity
BBI15_RS07995	COG2385	sporulation resulting in formation of a cellular spore
BBI15_RS08000	COG0791	NLP P60 protein
BBI15_RS08000	COG1388	LysM domain
BBI15_RS08005	COG0438	transferase activity, transferring glycosyl groups
BBI15_RS08010	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
BBI15_RS08015	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BBI15_RS08020	COG1115	amino acid carrier protein
BBI15_RS08025	COG1473	amidohydrolase
BBI15_RS08030	COG4187	Peptidase family M20/M25/M40
BBI15_RS08065	COG4608	Belongs to the ABC transporter superfamily
BBI15_RS08070	COG0791	NLP P60 protein
BBI15_RS08075	COG4948	Mandelate Racemase Muconate Lactonizing
BBI15_RS08080	COG1619	proteins homologs of microcin C7 resistance protein MccF
BBI15_RS08085	COG4166	transmembrane transport
BBI15_RS08090	COG0444	Belongs to the ABC transporter superfamily
BBI15_RS08100	COG0601	transmembrane transport
BBI15_RS08105	COG2362	D-Aminopeptidase
BBI15_RS08115	COG4715	Zinc finger, swim domain protein
BBI15_RS08120	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BBI15_RS08125	COG0629	single-stranded DNA binding
BBI15_RS08145	COG1077	Cell shape determining protein MreB Mrl
BBI15_RS08155	COG4836	Membrane
BBI15_RS08190	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BBI15_RS08215	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
BBI15_RS08220	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BBI15_RS08235	COG4475	Protein of unknown function (DUF436)
BBI15_RS08240	COG0698	ribose 5-phosphate isomerase
BBI15_RS08245	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BBI15_RS08250	COG0009	L-threonylcarbamoyladenylate synthase
BBI15_RS08260	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BBI15_RS08265	COG1435	thymidine kinase activity
BBI15_RS08270	COG0254	rRNA binding
BBI15_RS08275	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BBI15_RS08280	COG1494	fructose-1,6-bisphosphatase
BBI15_RS08285	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BBI15_RS08300	COG2204	response regulator
BBI15_RS08305	COG4821	SIS domain
BBI15_RS08320	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BBI15_RS08320	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BBI15_RS08320	COG1703	isobutyryl-CoA mutase activity
BBI15_RS08330	COG1960	acyl-CoA dehydrogenase activity
BBI15_RS08335	COG1960	acyl-CoA dehydrogenase activity
BBI15_RS08340	COG1250	3-hydroxyacyl-CoA dehydrogenase
BBI15_RS08345	COG0183	Belongs to the thiolase family
BBI15_RS08350	COG0247	lactate metabolic process
BBI15_RS08350	COG2181	nitrate reductase activity
BBI15_RS08380	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
BBI15_RS08395	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
BBI15_RS08400	COG1120	ATPase activity
BBI15_RS08405	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BBI15_RS08410	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BBI15_RS08415	COG0018	arginyl-trna synthetase
BBI15_RS08425	COG0010	Belongs to the arginase family
BBI15_RS08430	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BBI15_RS08445	COG3465	dGTPase activity
BBI15_RS08450	COG1078	dGTPase activity
BBI15_RS08460	COG3253	May function as heme-dependent peroxidase
BBI15_RS08475	COG2363	Small membrane protein
BBI15_RS08510	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BBI15_RS08515	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BBI15_RS08520	COG3314	Sporulation integral membrane protein YlbJ
BBI15_RS08525	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BBI15_RS08530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BBI15_RS08535	COG0765	amino acid transport
BBI15_RS08540	COG1126	abc transporter atp-binding protein
BBI15_RS08545	COG1288	antiporter activity
BBI15_RS08555	COG1473	amidohydrolase
BBI15_RS08560	COG0156	8-amino-7-oxononanoate synthase activity
BBI15_RS08565	COG1511	domain protein
BBI15_RS08565	COG1511	domain protein
BBI15_RS08570	COG1846	Transcriptional regulator
BBI15_RS08580	COG0626	cystathionine gamma-synthase activity
BBI15_RS08585	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BBI15_RS08590	COG1854	S-ribosylhomocysteine lyase activity
BBI15_RS08595	COG2226	methyltransferase
BBI15_RS08605	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BBI15_RS08610	COG0551	DNA topoisomerase type I activity
BBI15_RS08610	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BBI15_RS08615	COG0431	NADPH-dependent FMN reductase
BBI15_RS08630	COG0488	(ABC) transporter
BBI15_RS08640	COG1595	DNA-templated transcription, initiation
BBI15_RS08645	COG4536	flavin adenine dinucleotide binding
BBI15_RS08650	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BBI15_RS08655	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BBI15_RS08670	COG0584	glycerophosphoryl diester phosphodiesterase
BBI15_RS08690	COG1132	(ABC) transporter
BBI15_RS08695	COG1132	(ABC) transporter
BBI15_RS08700	COG0697	spore germination
BBI15_RS08710	COG3610	response to peptide
BBI15_RS08715	COG2966	Psort location CytoplasmicMembrane, score
BBI15_RS08720	COG1063	alcohol dehydrogenase
BBI15_RS08730	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BBI15_RS08740	COG1960	acyl-CoA dehydrogenase activity
BBI15_RS08750	COG1012	belongs to the aldehyde dehydrogenase family
BBI15_RS08755	COG0789	Transcriptional regulator
BBI15_RS08765	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BBI15_RS08770	COG0586	Pfam SNARE associated Golgi protein
BBI15_RS08775	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BBI15_RS08785	COG4145	pantothenate transmembrane transporter activity
BBI15_RS08800	COG5002	protein histidine kinase activity
BBI15_RS08805	COG0745	RESPONSE REGULATOR receiver
BBI15_RS08810	COG0697	spore germination
BBI15_RS08815	COG0166	Belongs to the GPI family
BBI15_RS08830	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BBI15_RS08835	COG2011	ABC-type metal ion transport system permease component
BBI15_RS08840	COG1464	Belongs to the NlpA lipoprotein family
BBI15_RS08860	COG0095	Lipoate-protein ligase
BBI15_RS08865	COG1366	Belongs to the anti-sigma-factor antagonist family
BBI15_RS08875	COG3871	stress protein (general stress protein 26)
BBI15_RS08880	COG1959	2 iron, 2 sulfur cluster binding
BBI15_RS08915	COG4895	conserved protein (DUF2196)
BBI15_RS08920	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
BBI15_RS08925	COG0753	catalase activity
BBI15_RS08930	COG2066	Belongs to the glutaminase family
BBI15_RS08935	COG0400	carboxylic ester hydrolase activity
BBI15_RS08940	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BBI15_RS08955	COG4667	esterase of the alpha-beta hydrolase superfamily
BBI15_RS08960	COG2135	peptidase activity
BBI15_RS08970	COG2814	Major facilitator Superfamily
BBI15_RS08975	COG0471	metal ion transport
BBI15_RS08985	COG1988	membrane-bound metal-dependent
BBI15_RS08995	COG1253	flavin adenine dinucleotide binding
BBI15_RS09005	COG1295	ribonuclease BN
BBI15_RS09015	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
BBI15_RS09020	COG2027	D-alanyl-D-alanine carboxypeptidase
BBI15_RS09025	COG1879	ABC-type sugar transport system periplasmic component
BBI15_RS09030	COG1172	Belongs to the binding-protein-dependent transport system permease family
BBI15_RS09035	COG1129	ABC transporter
BBI15_RS09040	COG1869	D-ribose catabolic process
BBI15_RS09045	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BBI15_RS09050	COG1609	Transcriptional regulator
BBI15_RS09060	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BBI15_RS09065	COG1024	Enoyl-CoA hydratase
BBI15_RS09075	COG0183	Belongs to the thiolase family
BBI15_RS09085	COG2031	fatty acid transporter
BBI15_RS09090	COG1028	Short-chain dehydrogenase reductase Sdr
BBI15_RS09110	COG1250	3-hydroxyacyl-CoA dehydrogenase
BBI15_RS09115	COG1024	Enoyl-CoA hydratase
BBI15_RS09120	COG2045	Belongs to the ComB family
BBI15_RS09125	COG1309	transcriptional regulator
BBI15_RS09145	COG1024	Enoyl-CoA hydratase
BBI15_RS09160	COG0318	PFAM AMP-dependent synthetase and ligase
BBI15_RS09165	COG0217	transcriptional regulatory protein
BBI15_RS09170	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
BBI15_RS09175	COG1011	Hydrolase
BBI15_RS09180	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BBI15_RS09185	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BBI15_RS09195	COG0463	Glycosyl transferase, family 2
BBI15_RS09205	COG4485	Bacterial membrane protein, YfhO
BBI15_RS09210	COG2032	superoxide dismutase activity
BBI15_RS09215	COG1028	Short-chain dehydrogenase reductase Sdr
BBI15_RS09225	COG3546	catalase activity
BBI15_RS09235	COG1366	Belongs to the anti-sigma-factor antagonist family
BBI15_RS09235	COG2202	Pas domain
BBI15_RS09250	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BBI15_RS09260	COG0745	RESPONSE REGULATOR receiver
BBI15_RS09265	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BBI15_RS09280	COG1408	metallophosphoesterase
BBI15_RS09285	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
BBI15_RS09290	COG1131	(ABC) transporter
BBI15_RS09300	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BBI15_RS09305	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BBI15_RS09330	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BBI15_RS09335	COG0730	response to heat
BBI15_RS09350	COG0425	Belongs to the sulfur carrier protein TusA family
BBI15_RS09355	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BBI15_RS09355	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BBI15_RS09360	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BBI15_RS09360	COG0425	Belongs to the sulfur carrier protein TusA family
BBI15_RS09365	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BBI15_RS09370	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BBI15_RS09375	COG2210	Belongs to the sulfur carrier protein TusA family
BBI15_RS09380	COG1937	Protein conserved in bacteria
BBI15_RS09385	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BBI15_RS09385	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BBI15_RS09420	COG4565	transcriptional regulatory protein
BBI15_RS09425	COG3290	protein histidine kinase activity
BBI15_RS09430	COG1764	response to oxidative stress
BBI15_RS09440	COG1464	Belongs to the NlpA lipoprotein family
BBI15_RS09445	COG2011	ABC-type metal ion transport system permease component
BBI15_RS09450	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BBI15_RS09455	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BBI15_RS09460	COG0436	Aminotransferase
BBI15_RS09480	COG1405	negative regulation of cell septum assembly
BBI15_RS09480	COG3012	SEC-C Motif Domain Protein
BBI15_RS09490	COG2323	membrane
BBI15_RS09495	COG1607	acyl-coa hydrolase
BBI15_RS09500	COG2746	aminoglycoside 3-N-acetyltransferase activity
BBI15_RS09520	COG1012	belongs to the aldehyde dehydrogenase family
BBI15_RS09525	COG1187	pseudouridine synthase activity
BBI15_RS09540	COG0517	IMP dehydrogenase activity
BBI15_RS09550	COG1126	abc transporter atp-binding protein
BBI15_RS09555	COG0765	amino acid transport
BBI15_RS09560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BBI15_RS09580	COG0463	Glycosyl transferase, family 2
BBI15_RS09585	COG1233	COG1233 Phytoene dehydrogenase and related
BBI15_RS09590	COG1562	ergosterol biosynthetic process
BBI15_RS09605	COG3584	3D domain protein
BBI15_RS09605	COG1388	LysM domain
BBI15_RS09620	COG2308	Evidence 4 Homologs of previously reported genes of
BBI15_RS09640	COG0493	'glutamate synthase
BBI15_RS09645	COG0070	glutamate synthase
BBI15_RS09645	COG0067	glutamate synthase
BBI15_RS09645	COG0069	glutamate synthase activity
BBI15_RS09655	COG0514	ATP-dependent DNA helicase (RecQ)
BBI15_RS09665	COG1028	Short-chain dehydrogenase reductase Sdr
BBI15_RS09675	COG1396	sequence-specific DNA binding
BBI15_RS09700	COG0753	catalase activity
BBI15_RS09705	COG1215	transferase activity, transferring glycosyl groups
BBI15_RS09705	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BBI15_RS09710	COG0708	Exodeoxyribonuclease III
BBI15_RS09715	COG2270	Major facilitator Superfamily
BBI15_RS09725	COG3842	ATPase activity
BBI15_RS09730	COG1653	transport
BBI15_RS09735	COG1175	transmembrane transport
BBI15_RS09740	COG0395	ABC-type sugar transport system, permease component
BBI15_RS09745	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BBI15_RS09755	COG0427	acetyl-CoA hydrolase
BBI15_RS09760	COG3279	Response regulator of the LytR AlgR family
BBI15_RS09765	COG0427	acetyl-CoA hydrolase
BBI15_RS09770	COG2814	Major facilitator Superfamily
BBI15_RS09790	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BBI15_RS09795	COG2814	Major facilitator Superfamily
BBI15_RS09800	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BBI15_RS09815	COG2321	neutral zinc metallopeptidase
BBI15_RS09825	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BBI15_RS09830	COG1366	Belongs to the anti-sigma-factor antagonist family
BBI15_RS09835	COG2247	cell wall binding repeat
BBI15_RS09835	COG0860	N-Acetylmuramoyl-L-alanine amidase
BBI15_RS09850	COG0300	oxidoreductase activity
BBI15_RS09855	COG4221	oxidoreductase activity
BBI15_RS09865	COG1595	DNA-templated transcription, initiation
BBI15_RS09895	COG5001	Diguanylate cyclase
BBI15_RS09895	COG3300	MHYT domain
BBI15_RS09920	COG3279	Response regulator of the LytR AlgR family
BBI15_RS09935	COG0488	(ABC) transporter
BBI15_RS09945	COG0667	Aldo Keto reductase
BBI15_RS09980	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BBI15_RS10000	COG1061	Type III restriction enzyme res subunit
BBI15_RS10030	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BBI15_RS10035	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
BBI15_RS10040	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BBI15_RS10065	COG0739	heme binding
BBI15_RS10065	COG0741	lytic transglycosylase activity
BBI15_RS10065	COG1196	nuclear chromosome segregation
BBI15_RS10070	COG0366	Alpha amylase catalytic
BBI15_RS10090	COG2226	methyltransferase
BBI15_RS10110	COG0385	Bile acid
BBI15_RS10240	COG1028	Short-chain dehydrogenase reductase Sdr
BBI15_RS10275	COG2202	Pas domain
BBI15_RS10275	COG1366	Belongs to the anti-sigma-factor antagonist family
BBI15_RS10280	COG0789	Transcriptional regulator
BBI15_RS10290	COG0519	Catalyzes the synthesis of GMP from XMP
BBI15_RS10300	COG1404	Belongs to the peptidase S8 family
BBI15_RS10310	COG2234	aminopeptidase activity
BBI15_RS10315	COG2234	aminopeptidase activity
BBI15_RS10345	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BBI15_RS10350	COG1289	transmembrane transporter activity
BBI15_RS10360	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BBI15_RS10375	COG1959	2 iron, 2 sulfur cluster binding
BBI15_RS10390	COG0471	metal ion transport
BBI15_RS10395	COG2828	Protein conserved in bacteria
BBI15_RS10410	COG1794	racemase activity, acting on amino acids and derivatives
BBI15_RS10430	COG0656	L-ascorbic acid biosynthetic process
BBI15_RS10435	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BBI15_RS10440	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BBI15_RS10445	COG0569	domain protein
BBI15_RS10455	COG0668	transmembrane transport
BBI15_RS10460	COG1028	Short-chain dehydrogenase reductase Sdr
BBI15_RS10480	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
BBI15_RS10500	COG1215	transferase activity, transferring glycosyl groups
BBI15_RS10505	COG0745	RESPONSE REGULATOR receiver
BBI15_RS10510	COG5002	protein histidine kinase activity
BBI15_RS10515	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BBI15_RS10520	COG1366	Belongs to the anti-sigma-factor antagonist family
BBI15_RS10535	COG1028	Short-chain dehydrogenase reductase Sdr
BBI15_RS10555	COG1757	Na H antiporter
BBI15_RS10600	COG2132	Multicopper oxidase
BBI15_RS10620	COG0367	asparagine synthase
BBI15_RS10625	COG5002	protein histidine kinase activity
BBI15_RS10630	COG0745	RESPONSE REGULATOR receiver
BBI15_RS10645	COG2608	mercury ion transmembrane transporter activity
BBI15_RS10650	COG0745	RESPONSE REGULATOR receiver
BBI15_RS10655	COG5002	protein histidine kinase activity
BBI15_RS10665	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BBI15_RS10670	COG0785	Cytochrome C biogenesis protein
BBI15_RS10675	COG1388	LysM domain
BBI15_RS10680	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BBI15_RS10685	COG1686	Belongs to the peptidase S11 family
BBI15_RS10715	COG0534	Mate efflux family protein
BBI15_RS10755	COG2226	methyltransferase
BBI15_RS10775	COG2409	Drug exporters of the RND superfamily
BBI15_RS10790	COG0604	alcohol dehydrogenase
BBI15_RS10800	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BBI15_RS10800	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BBI15_RS10815	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BBI15_RS10820	COG1012	belongs to the aldehyde dehydrogenase family
BBI15_RS10825	COG3340	Belongs to the peptidase S51 family
BBI15_RS10855	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BBI15_RS10860	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BBI15_RS10870	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BBI15_RS10880	COG0179	Fumarylacetoacetate (FAA) hydrolase
BBI15_RS10905	COG3181	Tripartite tricarboxylate transporter family receptor
BBI15_RS10910	COG2059	Chromate
BBI15_RS10915	COG2059	Chromate
BBI15_RS10930	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BBI15_RS10935	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BBI15_RS10955	COG0066	3-isopropylmalate dehydratase activity
BBI15_RS10960	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BBI15_RS10965	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BBI15_RS10970	COG1802	Transcriptional regulator
BBI15_RS10975	COG2223	nitrite transmembrane transporter activity
BBI15_RS10980	COG0154	amidase activity
BBI15_RS11005	COG0716	FMN binding
BBI15_RS11010	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BBI15_RS11015	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BBI15_RS11030	COG0386	Belongs to the glutathione peroxidase family
BBI15_RS11035	COG1846	Transcriptional regulator
BBI15_RS11040	COG1764	response to oxidative stress
BBI15_RS11050	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BBI15_RS11055	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BBI15_RS11065	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BBI15_RS11070	COG0589	response to stress
BBI15_RS11080	COG0739	heme binding
BBI15_RS11100	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BBI15_RS11120	COG1301	dicarboxylic acid transport
BBI15_RS11125	COG2329	Antibiotic biosynthesis monooxygenase
BBI15_RS11135	COG2814	Major facilitator Superfamily
BBI15_RS11140	COG0662	Cupin 2, conserved barrel domain protein
BBI15_RS11145	COG0492	ferredoxin-NADP+ reductase activity
BBI15_RS11150	COG1120	ATPase activity
BBI15_RS11155	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BBI15_RS11160	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BBI15_RS11165	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BBI15_RS11170	COG1757	Na H antiporter
BBI15_RS11180	COG2239	Acts as a magnesium transporter
BBI15_RS11215	COG1785	Belongs to the alkaline phosphatase family
BBI15_RS11220	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BBI15_RS11225	COG1309	transcriptional regulator
BBI15_RS11230	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BBI15_RS11240	COG1496	oxidoreductase activity
BBI15_RS11245	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BBI15_RS11255	COG1028	Short-chain dehydrogenase reductase Sdr
BBI15_RS11270	COG0579	oxidoreductase
BBI15_RS11275	COG0519	Catalyzes the synthesis of GMP from XMP
BBI15_RS11300	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BBI15_RS11320	COG0747	negative chemotaxis
BBI15_RS11325	COG4894	glucomannan catabolic process
BBI15_RS11345	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
BBI15_RS11360	COG4608	Belongs to the ABC transporter superfamily
BBI15_RS11365	COG0444	Belongs to the ABC transporter superfamily
BBI15_RS11370	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BBI15_RS11380	COG0747	negative chemotaxis
BBI15_RS11390	COG2040	homocysteine
BBI15_RS11395	COG1126	abc transporter atp-binding protein
BBI15_RS11400	COG0765	amino acid transport
BBI15_RS11405	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BBI15_RS11415	COG0450	alkyl hydroperoxide reductase
BBI15_RS11440	COG3493	citrate carrier protein
BBI15_RS11445	COG4565	transcriptional regulatory protein
BBI15_RS11450	COG3290	protein histidine kinase activity
BBI15_RS11500	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BBI15_RS11510	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BBI15_RS11515	COG4853	Protein conserved in bacteria
BBI15_RS11525	COG5002	protein histidine kinase activity
BBI15_RS11530	COG0745	RESPONSE REGULATOR receiver
BBI15_RS11540	COG0739	heme binding
BBI15_RS11540	COG1196	nuclear chromosome segregation
BBI15_RS11540	COG0741	lytic transglycosylase activity
BBI15_RS11545	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BBI15_RS11550	COG0305	Participates in initiation and elongation during chromosome replication
BBI15_RS11555	COG0359	binds to the 23S rRNA
BBI15_RS11560	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
BBI15_RS11575	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BBI15_RS11585	COG0360	Binds together with S18 to 16S ribosomal RNA
BBI15_RS11600	COG0012	GTP binding
BBI15_RS11605	COG4481	Protein conserved in bacteria
BBI15_RS11610	COG0668	transmembrane transport
BBI15_RS11615	COG1811	Na channel or pump
BBI15_RS11620	COG1475	DNA binding
BBI15_RS11625	COG1192	Involved in chromosome partitioning
BBI15_RS11650	COG1847	R3H domain protein
BBI15_RS11660	COG0594	ribonuclease P activity
BBI15_RS11665	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BBI15_RS11670	COG0592	DNA-directed DNA polymerase activity
BBI15_RS11675	COG2501	S4 domain
BBI15_RS11690	COG0187	DNA topoisomerase II activity
BBI15_RS11695	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BBI15_RS11715	COG0516	GMP reductase activity
BBI15_RS11715	COG0517	IMP dehydrogenase activity
BBI15_RS11725	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BBI15_RS11735	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
BBI15_RS11745	COG0596	Alpha beta hydrolase
BBI15_RS11750	COG0590	tRNA wobble adenosine to inosine editing
BBI15_RS11755	COG1428	Deoxynucleoside kinase
BBI15_RS11760	COG1428	Deoxynucleoside kinase
BBI15_RS11775	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BBI15_RS11780	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BBI15_RS11785	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BBI15_RS11805	COG1982	Orn Lys Arg decarboxylase major
BBI15_RS11815	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BBI15_RS11820	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BBI15_RS11825	COG3870	Protein conserved in bacteria
BBI15_RS11830	COG0470	DNA polymerase III
BBI15_RS11835	COG1774	PSP1 C-terminal conserved region
BBI15_RS11840	COG4467	Involved in initiation control of chromosome replication
BBI15_RS11845	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
BBI15_RS11855	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BBI15_RS11860	COG2002	toxin-antitoxin pair type II binding
BBI15_RS11870	COG0084	hydrolase, TatD family'
BBI15_RS11875	COG3584	3D domain protein
BBI15_RS11875	COG3583	domain protein
BBI15_RS11890	COG4466	Protein conserved in bacteria
BBI15_RS11895	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BBI15_RS11900	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BBI15_RS11905	COG0251	oxidation-reduction process
BBI15_RS11915	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BBI15_RS11930	COG0193	aminoacyl-tRNA hydrolase activity
BBI15_RS11935	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BBI15_RS11940	COG2244	polysaccharide biosynthetic process
BBI15_RS11945	COG3956	TIGRFAM MazG family protein
BBI15_RS11950	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
BBI15_RS11955	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BBI15_RS11960	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BBI15_RS11965	COG0505	Belongs to the CarA family
BBI15_RS11970	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
BBI15_RS11975	COG1098	S1 RNA binding domain
BBI15_RS11995	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
BBI15_RS12000	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BBI15_RS12005	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BBI15_RS12010	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BBI15_RS12015	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BBI15_RS12020	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BBI15_RS12025	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BBI15_RS12030	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BBI15_RS12035	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BBI15_RS12040	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BBI15_RS12145	COG3869	Catalyzes the specific phosphorylation of arginine residues in
BBI15_RS12150	COG0542	response to heat
BBI15_RS12155	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
BBI15_RS12160	COG4956	integral membrane protein (PIN domain superfamily)
BBI15_RS12170	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BBI15_RS12180	COG1045	serine acetyltransferase
BBI15_RS12195	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BBI15_RS12200	COG3688	RNA-binding protein containing a PIN domain
BBI15_RS12210	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BBI15_RS12235	COG0222	ribosome binding
BBI15_RS12240	COG2813	Specifically methylates the guanine in position
BBI15_RS12255	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BBI15_RS12260	COG0049	tRNA binding
BBI15_RS12280	COG0028	Belongs to the TPP enzyme family
BBI15_RS12285	COG0440	acetolactate synthase activity
BBI15_RS12310	COG0066	3-isopropylmalate dehydratase activity
BBI15_RS12315	COG2056	Na+-H+ antiporter family
BBI15_RS12340	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BBI15_RS12365	COG0255	Belongs to the universal ribosomal protein uL29 family
BBI15_RS12370	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BBI15_RS12375	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BBI15_RS12420	COG0201	protein transport
BBI15_RS12430	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BBI15_RS12445	COG0202	RNA polymerase activity
BBI15_RS12455	COG1122	ATPase activity
BBI15_RS12465	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
BBI15_RS12470	COG0101	tRNA pseudouridine synthase activity
BBI15_RS12475	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BBI15_RS12490	COG0489	protein tyrosine kinase activity
BBI15_RS12495	COG2194	sulfuric ester hydrolase activity
BBI15_RS12550	COG0372	Belongs to the citrate synthase family
BBI15_RS12570	COG1595	DNA-templated transcription, initiation
BBI15_RS12575	COG5662	AntiSigma factor
BBI15_RS12580	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
BBI15_RS12595	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BBI15_RS12600	COG3708	Transcriptional regulator
BBI15_RS12600	COG2207	Transcriptional regulator
BBI15_RS12605	COG0431	NADPH-dependent FMN reductase
BBI15_RS12610	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BBI15_RS12625	COG1695	Transcriptional regulator
BBI15_RS12635	COG1253	flavin adenine dinucleotide binding
BBI15_RS12640	COG1253	flavin adenine dinucleotide binding
BBI15_RS12645	COG1253	flavin adenine dinucleotide binding
BBI15_RS12650	COG0861	Integral membrane protein TerC family
BBI15_RS12655	COG0488	(ABC) transporter
BBI15_RS12660	COG1136	(ABC) transporter
BBI15_RS12665	COG0577	efflux transmembrane transporter activity
BBI15_RS12675	COG5002	protein histidine kinase activity
BBI15_RS12675	COG3850	Histidine kinase
BBI15_RS12690	COG2050	protein possibly involved in aromatic compounds catabolism
BBI15_RS12695	COG5646	InterPro IPR014922
BBI15_RS12700	COG5001	Diguanylate cyclase
BBI15_RS12700	COG3300	MHYT domain
BBI15_RS12710	COG1366	Belongs to the anti-sigma-factor antagonist family
BBI15_RS12715	COG3437	response regulator, receiver
BBI15_RS12730	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
BBI15_RS12735	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
BBI15_RS12740	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BBI15_RS12755	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
BBI15_RS12765	COG1516	flagellar protein fliS
BBI15_RS12770	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BBI15_RS12775	COG1360	Flagellar Motor Protein
BBI15_RS12800	COG1256	bacterial-type flagellum assembly
BBI15_RS12800	COG4786	Flagellar basal body rod
BBI15_RS12805	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BBI15_RS12810	COG4786	Flagellar basal body rod
BBI15_RS12815	COG4786	Flagellar basal body rod
BBI15_RS12820	COG1815	bacterial-type flagellum-dependent cell motility
BBI15_RS12825	COG1558	bacterial-type flagellum-dependent cell motility
BBI15_RS12830	COG1677	Flagellar hook-basal body complex protein FliE
BBI15_RS12835	COG1766	The M ring may be actively involved in energy transduction
BBI15_RS12840	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BBI15_RS12850	COG1157	protein secretion by the type III secretion system
BBI15_RS12855	COG2882	bacterial-type flagellum organization
BBI15_RS12865	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
BBI15_RS12870	COG4786	Flagellar basal body rod
BBI15_RS12880	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BBI15_RS12885	COG1776	CheC inhibitor of MCP methylation
BBI15_RS12885	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BBI15_RS12890	COG3190	flagellar
BBI15_RS12895	COG1338	Plays a role in the flagellum-specific transport system
BBI15_RS12900	COG1987	bacterial-type flagellum assembly
BBI15_RS12905	COG1684	flagellar biosynthetic protein fliR
BBI15_RS12910	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BBI15_RS12915	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BBI15_RS12920	COG1419	protein localization to endoplasmic reticulum
BBI15_RS12925	COG0455	bacterial-type flagellum organization
BBI15_RS12930	COG1191	sigma factor activity
BBI15_RS12940	COG1728	Protein conserved in bacteria
BBI15_RS12950	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
BBI15_RS12955	COG0235	Class ii aldolase
BBI15_RS12965	COG1850	ribulose-bisphosphate carboxylase activity
BBI15_RS12970	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
BBI15_RS12975	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
BBI15_RS12985	COG1129	ABC transporter
BBI15_RS12990	COG1172	Belongs to the binding-protein-dependent transport system permease family
BBI15_RS13005	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
BBI15_RS13010	COG4336	lyase activity
BBI15_RS13015	COG1914	H( )-stimulated, divalent metal cation uptake system
BBI15_RS13020	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
BBI15_RS13025	COG1984	allophanate hydrolase subunit 2
BBI15_RS13030	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
BBI15_RS13035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BBI15_RS13045	COG1131	(ABC) transporter
BBI15_RS13060	COG1346	cytolysis
BBI15_RS13065	COG1380	Effector of murein hydrolase LrgA
BBI15_RS13070	COG1114	Component of the transport system for branched-chain amino acids
BBI15_RS13075	COG1802	Transcriptional regulator
BBI15_RS13095	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BBI15_RS13100	COG2223	nitrite transmembrane transporter activity
BBI15_RS13105	COG1132	(ABC) transporter
BBI15_RS13110	COG0789	Transcriptional regulator
BBI15_RS13130	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BBI15_RS13140	COG2124	cytochrome p450
BBI15_RS13150	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BBI15_RS13170	COG1366	Belongs to the anti-sigma-factor antagonist family
BBI15_RS13170	COG2202	Pas domain
BBI15_RS13185	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BBI15_RS13190	COG3409	Peptidoglycan-binding domain 1 protein
BBI15_RS13190	COG3773	Cell wall hydrolase
BBI15_RS13195	COG0395	ABC-type sugar transport system, permease component
BBI15_RS13200	COG1175	transmembrane transport
BBI15_RS13210	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BBI15_RS13215	COG0512	Glutamine amidotransferase of anthranilate synthase
BBI15_RS13215	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BBI15_RS13220	COG1834	amidinotransferase
BBI15_RS13225	COG0322	excinuclease ABC activity
BBI15_RS13245	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BBI15_RS13250	COG0492	ferredoxin-NADP+ reductase activity
BBI15_RS13270	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BBI15_RS13275	COG0390	transport system, permease component
BBI15_RS13285	COG1404	Belongs to the peptidase S8 family
BBI15_RS13295	COG5146	pantothenate kinase activity
BBI15_RS13300	COG0778	Nitroreductase
BBI15_RS13305	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
BBI15_RS13310	COG0791	NLP P60 protein
BBI15_RS13310	COG1388	LysM domain
BBI15_RS13320	COG2050	protein possibly involved in aromatic compounds catabolism
BBI15_RS13325	COG1309	transcriptional regulator
BBI15_RS13335	COG2759	Belongs to the formate--tetrahydrofolate ligase family
BBI15_RS13365	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BBI15_RS13370	COG2233	PERMEase
BBI15_RS13385	COG0346	lactoylglutathione lyase activity
BBI15_RS13390	COG0506	proline dehydrogenase activity
BBI15_RS13405	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BBI15_RS13410	COG2706	6-phosphogluconolactonase activity
BBI15_RS13420	COG1999	signal sequence binding
BBI15_RS13430	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BBI15_RS13435	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BBI15_RS13445	COG0058	SHG alpha-glucan phosphorylase activity
BBI15_RS13450	COG1028	Short-chain dehydrogenase reductase Sdr
BBI15_RS13470	COG3949	Membrane
BBI15_RS13480	COG1234	tRNA 3'-trailer cleavage
BBI15_RS13485	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BBI15_RS13495	COG2233	PERMEase
BBI15_RS13500	COG1164	Oligoendopeptidase f
BBI15_RS13540	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BBI15_RS13545	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BBI15_RS13560	COG1028	Short-chain dehydrogenase reductase Sdr
BBI15_RS13565	COG1960	acyl-CoA dehydrogenase activity
BBI15_RS13575	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BBI15_RS13580	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BBI15_RS13585	COG1966	Carbon starvation protein
BBI15_RS13595	COG0003	Pfam Anion-transporting ATPase
BBI15_RS13600	COG0604	alcohol dehydrogenase
BBI15_RS13645	COG0427	acetyl-CoA hydrolase
BBI15_RS13655	COG1366	Belongs to the anti-sigma-factor antagonist family
BBI15_RS13670	COG1671	Belongs to the UPF0178 family
BBI15_RS13685	COG0628	permease
BBI15_RS13690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BBI15_RS13695	COG0765	amino acid transport
BBI15_RS13700	COG1126	abc transporter atp-binding protein
BBI15_RS13710	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BBI15_RS13715	COG1028	Short-chain dehydrogenase reductase Sdr
BBI15_RS13720	COG0492	ferredoxin-NADP+ reductase activity
BBI15_RS13730	COG3584	3D domain protein
BBI15_RS13730	COG1388	LysM domain
BBI15_RS13745	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BBI15_RS13750	COG0805	protein transport
BBI15_RS13760	COG0456	acetyltransferase
BBI15_RS13760	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
BBI15_RS13770	COG0598	Magnesium transport protein CorA
BBI15_RS13780	COG1733	regulation of RNA biosynthetic process
BBI15_RS13785	COG2514	catechol 2,3-dioxygenase activity
BBI15_RS13795	COG2070	2-Nitropropane dioxygenase
BBI15_RS13815	COG0628	permease
BBI15_RS13820	COG1846	Transcriptional regulator
BBI15_RS13825	COG1033	growth of symbiont in host cell
BBI15_RS13825	COG2409	Drug exporters of the RND superfamily
BBI15_RS13835	COG0456	acetyltransferase
BBI15_RS13845	COG1278	Cold shock
BBI15_RS13860	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BBI15_RS13885	COG0589	response to stress
BBI15_RS13900	COG0659	secondary active sulfate transmembrane transporter activity
BBI15_RS13910	COG4607	ABC-type enterochelin transport system periplasmic component
BBI15_RS13930	COG1846	Transcriptional regulator
BBI15_RS13935	COG0346	lactoylglutathione lyase activity
BBI15_RS13945	COG0307	riboflavin synthase, alpha
BBI15_RS13955	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BBI15_RS13970	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BBI15_RS13980	COG1876	peptidase activity
BBI15_RS13990	COG0702	epimerase
BBI15_RS13995	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
BBI15_RS14000	COG1131	(ABC) transporter
BBI15_RS14020	COG0318	PFAM AMP-dependent synthetase and ligase
BBI15_RS14025	COG0655	NAD(P)H dehydrogenase (quinone) activity
BBI15_RS14035	COG4988	ABC transporter
BBI15_RS14040	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BBI15_RS14050	COG3239	Fatty acid desaturase
BBI15_RS14055	COG4585	Histidine kinase
BBI15_RS14060	COG2197	response regulator
BBI15_RS14065	COG4876	unkown
BBI15_RS14070	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BBI15_RS14075	COG2764	glyoxalase bleomycin resistance protein dioxygenase
BBI15_RS14090	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BBI15_RS14105	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BBI15_RS14110	COG4605	iron ion homeostasis
BBI15_RS14115	COG4604	ABC transporter, ATP-binding protein
BBI15_RS14120	COG0671	phosphoesterase, PA-phosphatase related
BBI15_RS14125	COG0004	ammonium transporteR
BBI15_RS14130	COG0347	Belongs to the P(II) protein family
BBI15_RS14150	COG0477	Major facilitator Superfamily
BBI15_RS14165	COG1174	glycine betaine transport
BBI15_RS14170	COG1732	Glycine betaine
BBI15_RS14175	COG0183	Belongs to the thiolase family
BBI15_RS14195	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BBI15_RS14200	COG0134	indole-3-glycerol-phosphate synthase activity
BBI15_RS14205	COG0133	tryptophan synthase activity
BBI15_RS14215	COG2094	Belongs to the DNA glycosylase MPG family
BBI15_RS14220	COG0693	protein deglycase activity
BBI15_RS14225	COG0640	Transcriptional regulator
BBI15_RS14230	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BBI15_RS14240	COG1227	inorganic diphosphatase activity
BBI15_RS14245	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BBI15_RS14255	COG0723	plastoquinol--plastocyanin reductase activity
BBI15_RS14255	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BBI15_RS14260	COG2353	YceI-like domain
BBI15_RS14265	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BBI15_RS14280	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BBI15_RS14285	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BBI15_RS14325	COG2996	Protein conserved in bacteria
BBI15_RS14335	COG0346	lactoylglutathione lyase activity
BBI15_RS14355	COG2153	protein acetylation
BBI15_RS14370	COG1597	lipid kinase activity
BBI15_RS14390	COG2814	Major facilitator Superfamily
BBI15_RS14395	COG1876	peptidase activity
BBI15_RS14400	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BBI15_RS14415	COG0438	transferase activity, transferring glycosyl groups
BBI15_RS14420	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BBI15_RS14425	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BBI15_RS14440	COG1028	Short-chain dehydrogenase reductase Sdr
BBI15_RS14455	COG2217	Heavy metal translocating P-type atpase
BBI15_RS14460	COG2608	mercury ion transmembrane transporter activity
BBI15_RS14465	COG1937	Protein conserved in bacteria
BBI15_RS14470	COG0772	Belongs to the SEDS family
BBI15_RS14480	COG1181	Belongs to the D-alanine--D-alanine ligase family
BBI15_RS14485	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BBI15_RS14495	COG0513	Belongs to the DEAD box helicase family
BBI15_RS14500	COG3402	PFAM membrane-flanked domain
BBI15_RS14505	COG3428	Bacterial PH domain
BBI15_RS14510	COG0705	Rhomboid family
BBI15_RS14515	COG0736	holo-[acyl-carrier-protein] synthase activity
BBI15_RS14520	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BBI15_RS14530	COG2337	Toxic component of a toxin-antitoxin (TA) module
BBI15_RS14535	COG1366	Belongs to the anti-sigma-factor antagonist family
BBI15_RS14540	COG1366	Belongs to the anti-sigma-factor antagonist family
BBI15_RS14545	COG2172	sigma factor antagonist activity
BBI15_RS14550	COG2208	phosphoserine phosphatase activity
BBI15_RS14555	COG1366	Belongs to the anti-sigma-factor antagonist family
BBI15_RS14560	COG2172	sigma factor antagonist activity
BBI15_RS14565	COG1191	sigma factor activity
BBI15_RS14570	COG2208	phosphoserine phosphatase activity
BBI15_RS14575	COG2183	response to ionizing radiation
BBI15_RS14580	COG3091	SprT-like family
BBI15_RS14645	COG0802	atpase or kinase
BBI15_RS14650	COG1214	PFAM Peptidase M22, glycoprotease
BBI15_RS14655	COG0456	acetyltransferase
BBI15_RS14660	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BBI15_RS14665	COG0488	(ABC) transporter
BBI15_RS14675	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BBI15_RS14680	COG0805	protein transport
BBI15_RS14685	COG1266	CAAX protease self-immunity
BBI15_RS14690	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BBI15_RS14695	COG0459	protein refolding
BBI15_RS14700	COG1028	Short-chain dehydrogenase reductase Sdr
BBI15_RS14705	COG1464	Belongs to the NlpA lipoprotein family
BBI15_RS14710	COG1960	acyl-CoA dehydrogenase activity
BBI15_RS14715	COG1307	EDD domain protein, DegV family
BBI15_RS14720	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BBI15_RS14735	COG1309	transcriptional regulator
BBI15_RS14775	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BBI15_RS14775	COG0646	methionine synthase
BBI15_RS14780	COG1410	methionine synthase
BBI15_RS14780	COG0646	methionine synthase
BBI15_RS14785	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BBI15_RS14815	COG1388	LysM domain
BBI15_RS14840	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BBI15_RS14870	COG1396	sequence-specific DNA binding
BBI15_RS14875	COG0477	Major facilitator Superfamily
BBI15_RS14885	COG0300	oxidoreductase activity
BBI15_RS14890	COG1268	BioY protein
BBI15_RS14895	COG2169	Transcriptional regulator
BBI15_RS14900	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
BBI15_RS14905	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BBI15_RS14910	COG0110	maltose O-acetyltransferase activity
BBI15_RS14940	COG1609	Transcriptional regulator
BBI15_RS14945	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BBI15_RS14950	COG2610	gluconate transmembrane transporter activity
BBI15_RS14955	COG1250	3-hydroxyacyl-CoA dehydrogenase
BBI15_RS14960	COG1028	Short-chain dehydrogenase reductase Sdr
BBI15_RS14970	COG1301	dicarboxylic acid transport
BBI15_RS14975	COG1090	epimerase
BBI15_RS15020	COG2814	Major facilitator Superfamily
BBI15_RS15025	COG0745	RESPONSE REGULATOR receiver
BBI15_RS15030	COG5002	protein histidine kinase activity
BBI15_RS15030	COG3850	Histidine kinase
BBI15_RS15040	COG1136	(ABC) transporter
BBI15_RS15090	COG1396	sequence-specific DNA binding
BBI15_RS15100	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
BBI15_RS15110	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
BBI15_RS15180	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BBI15_RS15190	COG1902	pentaerythritol trinitrate reductase activity
BBI15_RS15205	COG1737	Transcriptional regulator
BBI15_RS15210	COG2133	pyrroloquinoline quinone binding
BBI15_RS15220	COG0535	radical SAM domain protein
BBI15_RS15250	COG2271	Major facilitator Superfamily
BBI15_RS15255	COG0277	FAD linked oxidase domain protein
BBI15_RS15300	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BBI15_RS15310	COG2318	DinB family
BBI15_RS15315	COG5505	Protein of unknown function (DUF819)
BBI15_RS15320	COG4129	membrane
BBI15_RS15325	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BBI15_RS15340	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BBI15_RS15345	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
BBI15_RS15350	COG1126	abc transporter atp-binding protein
BBI15_RS15355	COG0765	amino acid transport
BBI15_RS15360	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BBI15_RS15380	COG1966	Carbon starvation protein
BBI15_RS15385	COG0673	inositol 2-dehydrogenase activity
BBI15_RS15395	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BBI15_RS15395	COG1263	PTS System
BBI15_RS15395	COG2190	(PTS) system
BBI15_RS15400	COG3711	transcriptional antiterminator
BBI15_RS15415	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
BBI15_RS15420	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BBI15_RS15430	COG1233	COG1233 Phytoene dehydrogenase and related
BBI15_RS15435	COG2124	cytochrome p450
BBI15_RS15455	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BBI15_RS15495	COG0596	Alpha beta hydrolase
BBI15_RS15505	COG2112	serine threonine protein kinase
BBI15_RS15515	COG5002	protein histidine kinase activity
BBI15_RS15535	COG3402	PFAM membrane-flanked domain
BBI15_RS15550	COG1695	Transcriptional regulator
BBI15_RS15555	COG0747	negative chemotaxis
BBI15_RS15565	COG1285	pathogenesis
BBI15_RS15575	COG3764	Sortase (surface protein transpeptidase)
BBI15_RS15605	COG0628	permease
BBI15_RS15610	COG2897	thiosulfate sulfurtransferase activity
BBI15_RS15620	COG1028	Short-chain dehydrogenase reductase Sdr
BBI15_RS15640	COG1368	sulfuric ester hydrolase activity
BBI15_RS15650	COG1473	amidohydrolase
BBI15_RS15660	COG4948	Mandelate Racemase Muconate Lactonizing
BBI15_RS15665	COG3949	Membrane
BBI15_RS15685	COG2851	Citrate transporter
BBI15_RS15695	COG3290	protein histidine kinase activity
BBI15_RS15705	COG1131	(ABC) transporter
BBI15_RS15710	COG2188	Transcriptional regulator
BBI15_RS15715	COG1104	cysteine desulfurase activity
BBI15_RS15720	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
BBI15_RS15725	COG0157	Belongs to the NadC ModD family
BBI15_RS15735	COG1454	alcohol dehydrogenase
BBI15_RS15740	COG2130	NADP-dependent
BBI15_RS15745	COG1902	pentaerythritol trinitrate reductase activity
BBI15_RS15760	COG0583	DNA-binding transcription factor activity
BBI15_RS15780	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BBI15_RS15785	COG0805	protein transport
BBI15_RS15790	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BBI15_RS15795	COG1757	Na H antiporter
BBI15_RS15805	COG3655	Transcriptional regulator
BBI15_RS15815	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BBI15_RS15820	COG0022	dehydrogenase e1 component
BBI15_RS15825	COG0508	dehydrogenase complex catalyzes the overall conversion of
BBI15_RS15830	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BBI15_RS15900	COG0305	Participates in initiation and elongation during chromosome replication
BBI15_RS15910	COG1528	Iron-storage protein
BBI15_RS15935	COG2356	endonuclease I
BBI15_RS15955	COG0300	oxidoreductase activity
BBI15_RS15970	COG1288	antiporter activity
BBI15_RS15975	COG1842	Phage shock protein A
BBI15_RS15980	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BBI15_RS15990	COG4260	virion core protein, lumpy skin disease virus
BBI15_RS15995	COG1309	transcriptional regulator
BBI15_RS16010	COG1028	Short-chain dehydrogenase reductase Sdr
BBI15_RS16030	COG0318	PFAM AMP-dependent synthetase and ligase
BBI15_RS16035	COG4807	Protein conserved in bacteria
BBI15_RS16040	COG3588	fructose-bisphosphate aldolase
BBI15_RS16045	COG1028	Short-chain dehydrogenase reductase Sdr
BBI15_RS16050	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BBI15_RS16075	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BBI15_RS16080	COG0671	phosphoesterase, PA-phosphatase related
BBI15_RS16090	COG1366	Belongs to the anti-sigma-factor antagonist family
BBI15_RS16100	COG1028	Short-chain dehydrogenase reductase Sdr
BBI15_RS16110	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BBI15_RS16140	COG2326	polyphosphate kinase activity
BBI15_RS16145	COG2200	EAL domain
BBI15_RS16150	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BBI15_RS16160	COG2843	Capsule synthesis protein
BBI15_RS16185	COG1929	Belongs to the glycerate kinase type-1 family
BBI15_RS16195	COG0477	Major facilitator Superfamily
BBI15_RS16215	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BBI15_RS16220	COG1116	anion transmembrane transporter activity
BBI15_RS16225	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BBI15_RS16230	COG0569	domain protein
BBI15_RS16255	COG0583	DNA-binding transcription factor activity
BBI15_RS16260	COG2610	gluconate transmembrane transporter activity
BBI15_RS16265	COG1028	Short-chain dehydrogenase reductase Sdr
BBI15_RS16270	COG2267	carboxylic ester hydrolase activity
BBI15_RS16275	COG0398	Pfam SNARE associated Golgi protein