locus-tag	class	description
SL003B_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SL003B_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SL003B_RS00025	COG5002	protein histidine kinase activity
SL003B_RS00025	COG5001	Diguanylate cyclase
SL003B_RS00035	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SL003B_RS00045	COG0284	orotidine-5'-phosphate decarboxylase activity
SL003B_RS00050	COG0131	Imidazoleglycerol-phosphate dehydratase
SL003B_RS00060	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SL003B_RS00070	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SL003B_RS00080	COG0140	phosphoribosyl-ATP diphosphatase activity
SL003B_RS00085	COG1072	(Pantothenic acid kinase))
SL003B_RS00100	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
SL003B_RS00110	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
SL003B_RS00120	COG1420	regulation of RNA biosynthetic process
SL003B_RS00125	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
SL003B_RS00130	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SL003B_RS00135	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SL003B_RS00140	COG0052	Belongs to the universal ribosomal protein uS2 family
SL003B_RS00155	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
SL003B_RS00180	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
SL003B_RS00190	COG0189	ligase activity
SL003B_RS00195	COG0792	nuclease activity
SL003B_RS00200	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
SL003B_RS00210	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SL003B_RS00225	COG3384	dioxygenase
SL003B_RS00230	COG0756	dUTP diphosphatase activity
SL003B_RS00235	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SL003B_RS00250	COG0285	dihydrofolate synthase activity
SL003B_RS00255	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SL003B_RS00270	COG0133	tryptophan synthase activity
SL003B_RS00275	COG0135	phosphoribosylanthranilate isomerase activity
SL003B_RS00280	COG0281	malic enzyme
SL003B_RS00280	COG0280	phosphate acetyltransferase
SL003B_RS00285	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SL003B_RS00310	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SL003B_RS00320	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SL003B_RS00330	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
SL003B_RS00345	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SL003B_RS00350	COG0237	dephospho-CoA kinase activity
SL003B_RS00355	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SL003B_RS00360	COG0424	maF-like protein
SL003B_RS00365	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
SL003B_RS00370	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
SL003B_RS00375	COG1981	membrane
SL003B_RS00380	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
SL003B_RS00385	COG1331	Highly conserved protein containing a thioredoxin domain
SL003B_RS00390	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SL003B_RS00395	COG0445	tRNA wobble uridine modification
SL003B_RS00400	COG0357	Ribosomal RNA small subunit methyltransferase G
SL003B_RS00425	COG0495	leucyl-tRNA aminoacylation
SL003B_RS00430	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SL003B_RS00445	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SL003B_RS00460	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SL003B_RS00465	COG0335	large ribosomal subunit rRNA binding
SL003B_RS00470	COG0336	Belongs to the RNA methyltransferase TrmD family
SL003B_RS00480	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SL003B_RS00485	COG0228	four-way junction DNA binding
SL003B_RS00490	COG0287	Prephenate dehydrogenase
SL003B_RS00490	COG1605	Chorismate mutase
SL003B_RS00495	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SL003B_RS00500	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SL003B_RS00505	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
SL003B_RS00510	COG0830	nickel cation binding
SL003B_RS00520	COG0625	glutathione transferase activity
SL003B_RS00530	COG0804	urea catabolic process
SL003B_RS00535	COG3755	Protein conserved in bacteria
SL003B_RS00545	COG0831	urea catabolic process
SL003B_RS00550	COG0829	nickel cation binding
SL003B_RS00555	COG1686	Belongs to the peptidase S11 family
SL003B_RS00560	COG0523	cobalamin synthesis protein
SL003B_RS00565	COG1946	Acyl-CoA thioesterase
SL003B_RS00570	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SL003B_RS00575	COG0300	oxidoreductase activity
SL003B_RS00595	COG2086	electron transfer activity
SL003B_RS00600	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
SL003B_RS00605	COG1250	3-hydroxyacyl-CoA dehydrogenase
SL003B_RS00610	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SL003B_RS00630	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SL003B_RS00635	COG0165	Argininosuccinate lyase
SL003B_RS00640	COG0019	diaminopimelate decarboxylase activity
SL003B_RS00650	COG0745	RESPONSE REGULATOR receiver
SL003B_RS00665	COG2884	Cell division ATP-binding protein ftsE
SL003B_RS00740	COG0501	Belongs to the peptidase M48B family
SL003B_RS00755	COG0138	bifunctional purine biosynthesis protein purh
SL003B_RS00770	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SL003B_RS00775	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SL003B_RS00795	COG0745	RESPONSE REGULATOR receiver
SL003B_RS00805	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SL003B_RS00810	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SL003B_RS00815	COG0552	protein localization to endoplasmic reticulum
SL003B_RS00840	COG3012	SEC-C Motif Domain Protein
SL003B_RS00860	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SL003B_RS00865	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SL003B_RS00895	COG1595	DNA-templated transcription, initiation
SL003B_RS00905	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SL003B_RS00955	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SL003B_RS00960	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SL003B_RS00965	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SL003B_RS00975	COG0438	transferase activity, transferring glycosyl groups
SL003B_RS00980	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SL003B_RS00985	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SL003B_RS00990	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SL003B_RS01005	COG0405	Gamma-glutamyltransferase
SL003B_RS01020	COG0183	Belongs to the thiolase family
SL003B_RS01030	COG2917	probably involved in intracellular septation
SL003B_RS01040	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SL003B_RS01050	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SL003B_RS01060	COG3300	MHYT domain
SL003B_RS01060	COG5001	Diguanylate cyclase
SL003B_RS01065	COG0287	Prephenate dehydrogenase
SL003B_RS01070	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SL003B_RS01075	COG0077	Prephenate dehydratase
SL003B_RS01075	COG1605	Chorismate mutase
SL003B_RS01080	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SL003B_RS01095	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SL003B_RS01105	COG1217	gtp-binding protein TYPA
SL003B_RS01115	COG2814	Major facilitator Superfamily
SL003B_RS01120	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SL003B_RS01125	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SL003B_RS01145	COG0137	argininosuccinate synthase activity
SL003B_RS01150	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
SL003B_RS01160	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SL003B_RS01180	COG0671	phosphoesterase, PA-phosphatase related
SL003B_RS01190	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SL003B_RS01195	COG2154	pterin-4-alpha-carbinolamine dehydratase
SL003B_RS01210	COG0347	Belongs to the P(II) protein family
SL003B_RS01215	COG0004	ammonium transporteR
SL003B_RS01225	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SL003B_RS01235	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SL003B_RS01245	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SL003B_RS01250	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SL003B_RS01255	COG4133	protoheme IX ABC transporter activity
SL003B_RS01265	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
SL003B_RS01280	COG1872	DUF167
SL003B_RS01285	COG2835	tetraacyldisaccharide 4'-kinase activity
SL003B_RS01295	COG3118	belongs to the thioredoxin family
SL003B_RS01380	COG2948	multi-organism process
SL003B_RS01390	COG3701	Conjugal transfer protein
SL003B_RS01395	COG3846	protein secretion by the type IV secretion system
SL003B_RS01410	COG3451	type IV secretory pathway VirB4
SL003B_RS01425	COG4962	Type ii secretion system protein e
SL003B_RS01455	COG0741	lytic transglycosylase activity
SL003B_RS01485	COG1192	Involved in chromosome partitioning
SL003B_RS01575	COG4227	nucleotidyltransferase activity
SL003B_RS01640	COG1028	Short-chain dehydrogenase reductase Sdr
SL003B_RS01665	COG3034	peptidoglycan biosynthetic process
SL003B_RS01670	COG0825	malonyl-CoA metabolic process
SL003B_RS01685	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
SL003B_RS01715	COG4536	flavin adenine dinucleotide binding
SL003B_RS01720	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SL003B_RS01725	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SL003B_RS01730	COG4974	Belongs to the 'phage' integrase family
SL003B_RS01735	COG2030	dehydratase
SL003B_RS01750	COG0288	reversible hydration of carbon dioxide
SL003B_RS01760	COG2201	protein-glutamate methylesterase activity
SL003B_RS01765	COG0604	alcohol dehydrogenase
SL003B_RS01770	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SL003B_RS01770	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SL003B_RS01775	COG0535	radical SAM domain protein
SL003B_RS01780	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
SL003B_RS01785	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
SL003B_RS01790	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SL003B_RS01805	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SL003B_RS01825	COG2199	diguanylate cyclase activity
SL003B_RS01825	COG2200	EAL domain
SL003B_RS01825	COG2203	Gaf domain
SL003B_RS01830	COG1473	amidohydrolase
SL003B_RS01835	COG2264	protein methyltransferase activity
SL003B_RS01850	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SL003B_RS01860	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SL003B_RS01895	COG0471	metal ion transport
SL003B_RS01895	COG3273	potassium ion transport
SL003B_RS01900	COG1024	Enoyl-CoA hydratase
SL003B_RS01910	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SL003B_RS01915	COG4770	biotin carboxylase activity
SL003B_RS01920	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SL003B_RS01925	COG1309	transcriptional regulator
SL003B_RS01930	COG2326	polyphosphate kinase activity
SL003B_RS01940	COG0604	alcohol dehydrogenase
SL003B_RS01970	COG4783	chaperone-mediated protein folding
SL003B_RS01985	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
SL003B_RS02000	COG2197	response regulator
SL003B_RS02005	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
SL003B_RS02050	COG2205	protein histidine kinase activity
SL003B_RS02050	COG0784	Response regulator, receiver
SL003B_RS02050	COG2198	Histidine kinase
SL003B_RS02070	COG0411	ABC transporter
SL003B_RS02100	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
SL003B_RS02105	COG3454	Phosphonate metabolism
SL003B_RS02110	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
SL003B_RS02115	COG4778	phosphonate C-P lyase system protein PhnL
SL003B_RS02120	COG4107	phosphonate C-P lyase system protein PhnK
SL003B_RS02125	COG3627	carbon phosphorus lyase activity
SL003B_RS02130	COG3626	phosphonate metabolism
SL003B_RS02135	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
SL003B_RS02140	COG3624	Phosphonate C-P lyase system protein PhnG
SL003B_RS02145	COG2188	Transcriptional regulator
SL003B_RS02150	COG3025	triphosphatase activity
SL003B_RS02165	COG1238	metal cluster binding
SL003B_RS02185	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SL003B_RS02205	COG0670	Belongs to the BI1 family
SL003B_RS02210	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
SL003B_RS02215	COG4181	ATPase activity
SL003B_RS02225	COG0667	Aldo Keto reductase
SL003B_RS02230	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
SL003B_RS02240	COG3339	Conserved Protein
SL003B_RS02250	COG1295	ribonuclease BN
SL003B_RS02255	COG0697	spore germination
SL003B_RS02260	COG0840	transmembrane signaling receptor activity
SL003B_RS02275	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SL003B_RS02280	COG1376	ErfK ybiS ycfS ynhG family protein
SL003B_RS02295	COG0463	Glycosyl transferase, family 2
SL003B_RS02300	COG0653	protein targeting
SL003B_RS02305	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SL003B_RS02310	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SL003B_RS02315	COG0494	nUDIX hydrolase
SL003B_RS02330	COG1040	competence protein
SL003B_RS02365	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SL003B_RS02370	COG0527	aspartate kinase activity
SL003B_RS02380	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SL003B_RS02385	COG2890	protein-(glutamine-N5) methyltransferase activity
SL003B_RS02395	COG0542	response to heat
SL003B_RS02400	COG0739	heme binding
SL003B_RS02465	COG4227	nucleotidyltransferase activity
SL003B_RS02475	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
SL003B_RS02500	COG3293	Transposase
SL003B_RS02535	COG1475	DNA binding
SL003B_RS02545	COG5489	Protein of unknown function (DUF736)
SL003B_RS02615	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SL003B_RS02635	COG1160	GTP binding
SL003B_RS02650	COG0582	viral genome integration into host DNA
SL003B_RS02665	COG2801	Transposase and inactivated derivatives
SL003B_RS02670	COG2963	transposase activity
SL003B_RS02680	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SL003B_RS02685	COG1960	acyl-CoA dehydrogenase activity
SL003B_RS02690	COG2301	Belongs to the HpcH HpaI aldolase family
SL003B_RS02695	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
SL003B_RS02705	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
SL003B_RS02720	COG1250	3-hydroxyacyl-CoA dehydrogenase
SL003B_RS02725	COG0318	PFAM AMP-dependent synthetase and ligase
SL003B_RS02750	COG0473	3-isopropylmalate dehydrogenase activity
SL003B_RS02755	COG2828	Protein conserved in bacteria
SL003B_RS02765	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SL003B_RS02785	COG1176	ABC-type spermidine putrescine transport system, permease component I
SL003B_RS02790	COG1176	ABC-type spermidine putrescine transport system, permease component I
SL003B_RS02795	COG3842	ATPase activity
SL003B_RS02815	COG0826	peptidase U32
SL003B_RS02885	COG0535	radical SAM domain protein
SL003B_RS02900	COG1522	sequence-specific DNA binding
SL003B_RS02905	COG3391	amine dehydrogenase activity
SL003B_RS02910	COG2010	Cytochrome c
SL003B_RS02915	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SL003B_RS02920	COG2010	Cytochrome c
SL003B_RS02925	COG0348	domain, Protein
SL003B_RS02925	COG3901	Regulator of nitric oxide reductase transcription
SL003B_RS02945	COG0714	Associated with various cellular activities
SL003B_RS02955	COG1845	cytochrome c oxidase, subunit III
SL003B_RS02970	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SL003B_RS02980	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
SL003B_RS02995	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
SL003B_RS03010	COG0154	amidase activity
SL003B_RS03015	COG1122	ATPase activity
SL003B_RS03020	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SL003B_RS03030	COG1268	BioY protein
SL003B_RS03080	COG4227	nucleotidyltransferase activity
SL003B_RS03095	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SL003B_RS03105	COG0589	response to stress
SL003B_RS03115	COG1566	PFAM secretion protein HlyD family protein
SL003B_RS03120	COG2814	Major facilitator Superfamily
SL003B_RS03125	COG1733	regulation of RNA biosynthetic process
SL003B_RS03150	COG1475	DNA binding
SL003B_RS03155	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SL003B_RS03195	COG5489	Protein of unknown function (DUF736)
SL003B_RS03220	COG2801	Transposase and inactivated derivatives
SL003B_RS03285	COG2771	luxR family
SL003B_RS03290	COG3916	Acyl-homoserine-lactone synthase
SL003B_RS03305	COG0501	Belongs to the peptidase M48B family
SL003B_RS03320	COG0071	Belongs to the small heat shock protein (HSP20) family
SL003B_RS03325	COG0071	Belongs to the small heat shock protein (HSP20) family
SL003B_RS03335	COG1846	Transcriptional regulator
SL003B_RS03345	COG0542	response to heat
SL003B_RS03370	COG3118	belongs to the thioredoxin family
SL003B_RS03385	COG0582	viral genome integration into host DNA
SL003B_RS03405	COG4227	nucleotidyltransferase activity
SL003B_RS03410	COG0464	growth
SL003B_RS03415	COG1404	Belongs to the peptidase S8 family
SL003B_RS03450	COG3293	Transposase
SL003B_RS03470	COG1475	DNA binding
SL003B_RS03480	COG5489	Protein of unknown function (DUF736)
SL003B_RS03590	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
SL003B_RS03660	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
SL003B_RS03670	COG0583	DNA-binding transcription factor activity
SL003B_RS03675	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
SL003B_RS03680	COG0511	ligase activity, forming carbon-carbon bonds
SL003B_RS03685	COG0439	Biotin carboxylase
SL003B_RS03695	COG1984	allophanate hydrolase subunit 2
SL003B_RS03725	COG0559	Belongs to the binding-protein-dependent transport system permease family
SL003B_RS03750	COG0395	ABC-type sugar transport system, permease component
SL003B_RS03770	COG1349	DNA-binding transcription factor activity
SL003B_RS03805	COG4213	ABC transporter substrate-binding protein
SL003B_RS03810	COG4214	carbohydrate transport
SL003B_RS03815	COG1129	ABC transporter
SL003B_RS03820	COG1070	Carbohydrate kinase
SL003B_RS03825	COG2115	Belongs to the xylose isomerase family
SL003B_RS03840	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
SL003B_RS03850	COG1522	sequence-specific DNA binding
SL003B_RS03865	COG4191	Histidine kinase
SL003B_RS03875	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
SL003B_RS03885	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
SL003B_RS03890	COG3791	Glutathione-dependent formaldehyde-activating
SL003B_RS03900	COG0129	dihydroxy-acid dehydratase activity
SL003B_RS03910	COG2217	Heavy metal translocating P-type atpase
SL003B_RS03920	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SL003B_RS03925	COG0601	transmembrane transport
SL003B_RS03950	COG1393	Belongs to the ArsC family
SL003B_RS03970	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SL003B_RS03990	COG0738	Major facilitator superfamily
SL003B_RS04015	COG0251	oxidation-reduction process
SL003B_RS04030	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SL003B_RS04035	COG0402	S-adenosylhomocysteine deaminase activity
SL003B_RS04045	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
SL003B_RS04050	COG2249	NAD(P)H dehydrogenase (quinone) activity
SL003B_RS04065	COG3293	Transposase
SL003B_RS04075	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SL003B_RS04090	COG2885	chlorophyll binding
SL003B_RS04095	COG1609	Transcriptional regulator
SL003B_RS04100	COG0471	metal ion transport
SL003B_RS04110	COG0523	cobalamin synthesis protein
SL003B_RS04140	COG0583	DNA-binding transcription factor activity
SL003B_RS04165	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SL003B_RS04180	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
SL003B_RS04190	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
SL003B_RS04200	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
SL003B_RS04215	COG0784	Response regulator, receiver
SL003B_RS04215	COG4191	Histidine kinase
SL003B_RS04250	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
SL003B_RS04255	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SL003B_RS04260	COG0330	HflC and HflK could
SL003B_RS04275	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
SL003B_RS04290	COG2951	lytic endotransglycosylase activity
SL003B_RS04305	COG0067	glutamate synthase
SL003B_RS04305	COG0069	glutamate synthase activity
SL003B_RS04305	COG0070	glutamate synthase
SL003B_RS04315	COG3220	belongs to the UPF0276 family
SL003B_RS04335	COG0071	Belongs to the small heat shock protein (HSP20) family
SL003B_RS04370	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SL003B_RS04375	COG0457	Tetratricopeptide repeat
SL003B_RS04385	COG0469	pyruvate kinase activity
SL003B_RS04410	COG3750	Belongs to the UPF0335 family
SL003B_RS04420	COG2204	response regulator
SL003B_RS04445	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SL003B_RS04455	COG0564	pseudouridine synthase activity
SL003B_RS04465	COG0828	Belongs to the bacterial ribosomal protein bS21 family
SL003B_RS04470	COG0534	Mate efflux family protein
SL003B_RS04475	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
SL003B_RS04480	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SL003B_RS04490	COG0318	PFAM AMP-dependent synthetase and ligase
SL003B_RS04505	COG1028	Short-chain dehydrogenase reductase Sdr
SL003B_RS04510	COG1132	(ABC) transporter
SL003B_RS04515	COG0254	rRNA binding
SL003B_RS04530	COG0604	alcohol dehydrogenase
SL003B_RS04540	COG3263	regulation of cellular component size
SL003B_RS04555	COG0483	inositol monophosphate 1-phosphatase activity
SL003B_RS04560	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SL003B_RS04570	COG0352	thiamine-phosphate diphosphorylase activity
SL003B_RS04580	COG0126	phosphoglycerate kinase activity
SL003B_RS04615	COG1692	metallophosphoesterase
SL003B_RS04620	COG0217	transcriptional regulatory protein
SL003B_RS04635	COG0632	four-way junction helicase activity
SL003B_RS04640	COG2255	four-way junction helicase activity
SL003B_RS04650	COG0824	Thioesterase
SL003B_RS04655	COG0811	peptide transport
SL003B_RS04660	COG0848	biopolymer transport protein
SL003B_RS04670	COG0823	Involved in the tonB-independent uptake of proteins
SL003B_RS04675	COG2885	chlorophyll binding
SL003B_RS04685	COG0037	tRNA processing
SL003B_RS04690	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SL003B_RS04695	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SL003B_RS04710	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SL003B_RS04720	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SL003B_RS04730	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SL003B_RS04735	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SL003B_RS04740	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SL003B_RS04745	COG0564	pseudouridine synthase activity
SL003B_RS04760	COG0640	Transcriptional regulator
SL003B_RS04765	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SL003B_RS04770	COG0798	PFAM Bile acid sodium symporter
SL003B_RS04795	COG2198	Histidine kinase
SL003B_RS04795	COG0643	Histidine kinase
SL003B_RS04795	COG0784	Response regulator, receiver
SL003B_RS04805	COG0745	RESPONSE REGULATOR receiver
SL003B_RS04810	COG2201	protein-glutamate methylesterase activity
SL003B_RS04815	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
SL003B_RS04820	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
SL003B_RS04850	COG0668	transmembrane transport
SL003B_RS04855	COG0747	negative chemotaxis
SL003B_RS04860	COG0601	transmembrane transport
SL003B_RS04865	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SL003B_RS04870	COG0444	Belongs to the ABC transporter superfamily
SL003B_RS04875	COG4608	Belongs to the ABC transporter superfamily
SL003B_RS04880	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SL003B_RS04885	COG2183	response to ionizing radiation
SL003B_RS04895	COG1396	sequence-specific DNA binding
SL003B_RS04930	COG4176	ABC-type proline glycine betaine transport system permease component
SL003B_RS04935	COG0517	IMP dehydrogenase activity
SL003B_RS04935	COG4175	Glycine betaine
SL003B_RS04945	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SL003B_RS04950	COG1321	iron dependent repressor
SL003B_RS04950	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SL003B_RS04955	COG1121	(ABC) transporter
SL003B_RS04960	COG0803	Belongs to the bacterial solute-binding protein 9 family
SL003B_RS04965	COG0114	fumarate hydratase activity
SL003B_RS04990	COG4451	ribulose bisphosphate carboxylase, small
SL003B_RS05015	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
SL003B_RS05045	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SL003B_RS05055	COG1116	anion transmembrane transporter activity
SL003B_RS05080	COG2198	Histidine kinase
SL003B_RS05080	COG2205	protein histidine kinase activity
SL003B_RS05080	COG0784	Response regulator, receiver
SL003B_RS05085	COG2205	protein histidine kinase activity
SL003B_RS05090	COG0745	RESPONSE REGULATOR receiver
SL003B_RS05120	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
SL003B_RS05130	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
SL003B_RS05190	COG1131	(ABC) transporter
SL003B_RS05200	COG1136	(ABC) transporter
SL003B_RS05220	COG0024	Methionine aminopeptidase
SL003B_RS05225	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SL003B_RS05230	COG0022	dehydrogenase e1 component
SL003B_RS05240	COG0508	dehydrogenase complex catalyzes the overall conversion of
SL003B_RS05275	COG2084	Dehydrogenase
SL003B_RS05310	COG2358	TRAP transporter, solute receptor (TAXI family
SL003B_RS05315	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
SL003B_RS05345	COG0784	Response regulator, receiver
SL003B_RS05390	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SL003B_RS05400	COG2301	Belongs to the HpcH HpaI aldolase family
SL003B_RS05410	COG4770	biotin carboxylase activity
SL003B_RS05415	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SL003B_RS05425	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SL003B_RS05445	COG1172	Belongs to the binding-protein-dependent transport system permease family
SL003B_RS05450	COG0559	Belongs to the binding-protein-dependent transport system permease family
SL003B_RS05455	COG0318	PFAM AMP-dependent synthetase and ligase
SL003B_RS05465	COG1960	acyl-CoA dehydrogenase activity
SL003B_RS05480	COG0022	dehydrogenase e1 component
SL003B_RS05490	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SL003B_RS05510	COG2358	TRAP transporter, solute receptor (TAXI family
SL003B_RS05520	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SL003B_RS05530	COG0508	dehydrogenase complex catalyzes the overall conversion of
SL003B_RS05540	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SL003B_RS05555	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SL003B_RS05570	COG2358	TRAP transporter, solute receptor (TAXI family
SL003B_RS05580	COG0583	DNA-binding transcription factor activity
SL003B_RS05585	COG1454	alcohol dehydrogenase
SL003B_RS05590	COG3485	protocatechuate 3,4-dioxygenase
SL003B_RS05600	COG0583	DNA-binding transcription factor activity
SL003B_RS05615	COG3384	dioxygenase
SL003B_RS05620	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SL003B_RS05620	COG1116	anion transmembrane transporter activity
SL003B_RS05635	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SL003B_RS05640	COG3180	Ammonia monooxygenase
SL003B_RS05645	COG1012	belongs to the aldehyde dehydrogenase family
SL003B_RS05670	COG0583	DNA-binding transcription factor activity
SL003B_RS05675	COG0235	Class ii aldolase
SL003B_RS05690	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SL003B_RS05695	COG2186	Transcriptional regulator
SL003B_RS05700	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
SL003B_RS05720	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SL003B_RS05725	COG2084	Dehydrogenase
SL003B_RS05730	COG3395	kinase activity
SL003B_RS05735	COG3622	Belongs to the hyi family
SL003B_RS05755	COG0482	sulfurtransferase activity
SL003B_RS05785	COG1766	The M ring may be actively involved in energy transduction
SL003B_RS05790	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SL003B_RS05800	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SL003B_RS05805	COG2204	response regulator
SL003B_RS05810	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
SL003B_RS05825	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SL003B_RS05845	COG0435	Glutathione S-transferase
SL003B_RS05870	COG0714	Associated with various cellular activities
SL003B_RS05900	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
SL003B_RS05905	COG1132	(ABC) transporter
SL003B_RS05920	COG1132	(ABC) transporter
SL003B_RS05930	COG2857	Cytochrome c1
SL003B_RS05930	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SL003B_RS05935	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SL003B_RS05935	COG2857	Cytochrome c1
SL003B_RS05940	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SL003B_RS05950	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SL003B_RS05955	COG0778	Nitroreductase
SL003B_RS05960	COG0456	acetyltransferase
SL003B_RS05965	COG2030	dehydratase
SL003B_RS05970	COG2030	dehydratase
SL003B_RS05990	COG3273	potassium ion transport
SL003B_RS05990	COG0471	metal ion transport
SL003B_RS05995	COG0012	GTP binding
SL003B_RS06000	COG0193	aminoacyl-tRNA hydrolase activity
SL003B_RS06015	COG0583	DNA-binding transcription factor activity
SL003B_RS06020	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
SL003B_RS06030	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SL003B_RS06055	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SL003B_RS06080	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SL003B_RS06090	COG0745	RESPONSE REGULATOR receiver
SL003B_RS06095	COG1846	Transcriptional regulator
SL003B_RS06100	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SL003B_RS06105	COG2814	Major facilitator Superfamily
SL003B_RS06110	COG0314	molybdopterin synthase activity
SL003B_RS06120	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SL003B_RS06135	COG1435	thymidine kinase activity
SL003B_RS06145	COG0322	excinuclease ABC activity
SL003B_RS06150	COG1028	Short-chain dehydrogenase reductase Sdr
SL003B_RS06175	COG0625	glutathione transferase activity
SL003B_RS06195	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
SL003B_RS06205	COG1278	Cold shock
SL003B_RS06220	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SL003B_RS06245	COG0556	nucleotide-excision repair
SL003B_RS06335	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SL003B_RS06340	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SL003B_RS06345	COG0583	DNA-binding transcription factor activity
SL003B_RS06350	COG0492	ferredoxin-NADP+ reductase activity
SL003B_RS06360	COG1522	sequence-specific DNA binding
SL003B_RS06365	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SL003B_RS06370	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SL003B_RS06390	COG0505	Belongs to the CarA family
SL003B_RS06400	COG0358	DNA primase activity
SL003B_RS06405	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SL003B_RS06420	COG3038	cytochrome b561
SL003B_RS06425	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SL003B_RS06430	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
SL003B_RS06440	COG2968	Membrane
SL003B_RS06445	COG0628	permease
SL003B_RS06455	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
SL003B_RS06460	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
SL003B_RS06465	COG3639	organic phosphonate transmembrane transporter activity
SL003B_RS06470	COG3383	formate dehydrogenase (NAD+) activity
SL003B_RS06470	COG0243	molybdopterin cofactor binding
SL003B_RS06475	COG3383	formate dehydrogenase (NAD+) activity
SL003B_RS06475	COG0243	molybdopterin cofactor binding
SL003B_RS06480	COG0437	4 iron, 4 sulfur cluster binding
SL003B_RS06485	COG2864	formate dehydrogenase
SL003B_RS06495	COG1921	L-seryl-tRNASec selenium transferase activity
SL003B_RS06525	COG0709	Synthesizes selenophosphate from selenide and ATP
SL003B_RS06530	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SL003B_RS06535	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SL003B_RS06590	COG0583	DNA-binding transcription factor activity
SL003B_RS06595	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
SL003B_RS06625	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
SL003B_RS06635	COG1280	lysine exporter protein (LysE YggA)
SL003B_RS06735	COG0431	NADPH-dependent FMN reductase
SL003B_RS06740	COG5001	Diguanylate cyclase
SL003B_RS06745	COG0484	heat shock protein binding
SL003B_RS06750	COG3023	N-Acetylmuramoyl-L-alanine amidase
SL003B_RS06770	COG1283	sodium-dependent phosphate transmembrane transporter activity
SL003B_RS06775	COG2001	Belongs to the MraZ family
SL003B_RS06780	COG0275	rRNA processing
SL003B_RS06795	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SL003B_RS06805	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SL003B_RS06810	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SL003B_RS06820	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SL003B_RS06825	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SL003B_RS06830	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SL003B_RS06835	COG1181	Belongs to the D-alanine--D-alanine ligase family
SL003B_RS06840	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
SL003B_RS06845	COG0849	cell division
SL003B_RS06850	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SL003B_RS06860	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SL003B_RS06865	COG0497	DNA recombination
SL003B_RS06875	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SL003B_RS06880	COG0210	DNA helicase
SL003B_RS06885	COG2264	protein methyltransferase activity
SL003B_RS06895	COG0006	proline dipeptidase activity
SL003B_RS06895	COG0006	proline dipeptidase activity
SL003B_RS06905	COG0038	chloride channel
SL003B_RS06915	COG0277	FAD linked oxidase domain protein
SL003B_RS06940	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
SL003B_RS06945	COG3609	addiction module antidote protein, CC2985 family
SL003B_RS06960	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
SL003B_RS06965	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
SL003B_RS06980	COG2153	protein acetylation
SL003B_RS06985	COG0330	HflC and HflK could
SL003B_RS06990	COG0330	HflC and HflK could
SL003B_RS07000	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SL003B_RS07010	COG0560	Phosphoserine phosphatase
SL003B_RS07010	COG3830	Belongs to the UPF0237 family
SL003B_RS07015	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SL003B_RS07030	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SL003B_RS07035	COG0384	phenazine biosynthesis protein PhzF
SL003B_RS07040	COG2153	protein acetylation
SL003B_RS07055	COG1131	(ABC) transporter
SL003B_RS07060	COG0842	Transport permease protein
SL003B_RS07065	COG1686	Belongs to the peptidase S11 family
SL003B_RS07070	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SL003B_RS07080	COG2375	cellular response to nickel ion
SL003B_RS07095	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
SL003B_RS07100	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SL003B_RS07105	COG0440	acetolactate synthase activity
SL003B_RS07110	COG0028	Belongs to the TPP enzyme family
SL003B_RS07120	COG1959	2 iron, 2 sulfur cluster binding
SL003B_RS07125	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
SL003B_RS07135	COG4208	sulfate ABC transporter
SL003B_RS07140	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
SL003B_RS07145	COG1522	sequence-specific DNA binding
SL003B_RS07150	COG0450	alkyl hydroperoxide reductase
SL003B_RS07160	COG0431	NADPH-dependent FMN reductase
SL003B_RS07170	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SL003B_RS07185	COG1116	anion transmembrane transporter activity
SL003B_RS07235	COG1054	Belongs to the UPF0176 family
SL003B_RS07250	COG1522	sequence-specific DNA binding
SL003B_RS07255	COG0686	Belongs to the AlaDH PNT family
SL003B_RS07275	COG0166	Belongs to the GPI family
SL003B_RS07310	COG0310	cobalt ion transport
SL003B_RS07320	COG0864	Transcriptional regulator
SL003B_RS07330	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SL003B_RS07335	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SL003B_RS07340	COG1238	metal cluster binding
SL003B_RS07345	COG2824	Alkylphosphonate utilization operon protein PhnA
SL003B_RS07370	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SL003B_RS07375	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
SL003B_RS07380	COG0318	PFAM AMP-dependent synthetase and ligase
SL003B_RS07385	COG0697	spore germination
SL003B_RS07400	COG0346	lactoylglutathione lyase activity
SL003B_RS07420	COG2863	cytochrome
SL003B_RS07425	COG1136	(ABC) transporter
SL003B_RS07425	COG0577	efflux transmembrane transporter activity
SL003B_RS07450	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
SL003B_RS07470	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
SL003B_RS07475	COG0351	phosphomethylpyrimidine kinase
SL003B_RS07480	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
SL003B_RS07485	COG0179	Fumarylacetoacetate (FAA) hydrolase
SL003B_RS07490	COG2067	long-chain fatty acid transport protein
SL003B_RS07495	COG1028	Short-chain dehydrogenase reductase Sdr
SL003B_RS07505	COG0438	transferase activity, transferring glycosyl groups
SL003B_RS07525	COG2814	Major facilitator Superfamily
SL003B_RS07530	COG4948	Mandelate Racemase Muconate Lactonizing
SL003B_RS07540	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SL003B_RS07545	COG1127	ABC transporter
SL003B_RS07555	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
SL003B_RS07555	COG3218	ABC-type transport auxiliary lipoprotein component
SL003B_RS07570	COG0633	Ferredoxin
SL003B_RS07580	COG1136	(ABC) transporter
SL003B_RS07580	COG0577	efflux transmembrane transporter activity
SL003B_RS07585	COG0577	efflux transmembrane transporter activity
SL003B_RS07585	COG1136	(ABC) transporter
SL003B_RS07610	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
SL003B_RS07625	COG2326	polyphosphate kinase activity
SL003B_RS07630	COG3768	UPF0283 membrane protein
SL003B_RS07635	COG3106	COG3106 Predicted ATPase
SL003B_RS07640	COG2062	phosphohistidine phosphatase, SixA
SL003B_RS07645	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SL003B_RS07660	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SL003B_RS07665	COG1749	Flagellar hook protein flgE
SL003B_RS07685	COG5443	negative regulation of bacterial-type flagellum assembly
SL003B_RS07705	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
SL003B_RS07720	COG3951	Flagellar rod assembly protein muramidase FlgJ
SL003B_RS07725	COG1706	bacterial-type flagellum-dependent cell motility
SL003B_RS07740	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
SL003B_RS07750	COG4786	Flagellar basal body rod
SL003B_RS07755	COG4786	Flagellar basal body rod
SL003B_RS07785	COG1338	Plays a role in the flagellum-specific transport system
SL003B_RS07800	COG1558	bacterial-type flagellum-dependent cell motility
SL003B_RS07805	COG1677	Flagellar hook-basal body complex protein FliE
SL003B_RS07810	COG1987	bacterial-type flagellum assembly
SL003B_RS07815	COG1684	flagellar biosynthetic protein fliR
SL003B_RS07820	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
SL003B_RS07855	COG2313	pseudouridylate synthase activity
SL003B_RS07860	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SL003B_RS07870	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SL003B_RS07875	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SL003B_RS07880	COG0538	isocitrate dehydrogenase activity
SL003B_RS07910	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SL003B_RS07915	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SL003B_RS07925	COG0037	tRNA processing
SL003B_RS07935	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
SL003B_RS07945	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SL003B_RS07975	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SL003B_RS07980	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SL003B_RS08010	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SL003B_RS08035	COG1522	sequence-specific DNA binding
SL003B_RS08045	COG3191	aminopeptidase activity
SL003B_RS08050	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SL003B_RS08060	COG1376	ErfK ybiS ycfS ynhG family protein
SL003B_RS08065	COG2391	methyltransferase activity
SL003B_RS08075	COG1380	Effector of murein hydrolase LrgA
SL003B_RS08080	COG1346	cytolysis
SL003B_RS08100	COG5425	PFAM Usg family protein
SL003B_RS08115	COG0142	geranyltranstransferase activity
SL003B_RS08120	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SL003B_RS08130	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SL003B_RS08130	COG0574	Belongs to the PEP-utilizing enzyme family
SL003B_RS08145	COG5001	Diguanylate cyclase
SL003B_RS08145	COG3300	MHYT domain
SL003B_RS08150	COG2003	Belongs to the UPF0758 family
SL003B_RS08155	COG0024	Methionine aminopeptidase
SL003B_RS08165	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SL003B_RS08170	COG1489	DNA binding
SL003B_RS08185	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
SL003B_RS08190	COG1546	Belongs to the CinA family
SL003B_RS08190	COG1058	Belongs to the CinA family
SL003B_RS08195	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SL003B_RS08205	COG2267	carboxylic ester hydrolase activity
SL003B_RS08215	COG1024	Enoyl-CoA hydratase
SL003B_RS08270	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SL003B_RS08275	COG0302	gtp cyclohydrolase
SL003B_RS08285	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SL003B_RS08290	COG1032	radical SAM domain protein
SL003B_RS08300	COG0189	ligase activity
SL003B_RS08305	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SL003B_RS08320	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SL003B_RS08340	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SL003B_RS08670	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SL003B_RS08690	COG0523	cobalamin synthesis protein
SL003B_RS08720	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SL003B_RS08740	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SL003B_RS08745	COG0081	regulation of translation
SL003B_RS08750	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SL003B_RS08755	COG0222	ribosome binding
SL003B_RS08760	COG0085	RNA polymerase activity
SL003B_RS08775	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SL003B_RS08780	COG0049	tRNA binding
SL003B_RS08785	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SL003B_RS08790	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SL003B_RS08795	COG0051	transcription antitermination factor activity, RNA binding
SL003B_RS08800	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SL003B_RS08805	COG0088	Forms part of the polypeptide exit tunnel
SL003B_RS08810	COG0089	rRNA binding
SL003B_RS08815	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SL003B_RS08825	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SL003B_RS08830	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SL003B_RS08835	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SL003B_RS08845	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SL003B_RS08850	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SL003B_RS08855	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SL003B_RS08860	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SL003B_RS08865	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SL003B_RS08870	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SL003B_RS08880	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SL003B_RS08885	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SL003B_RS08895	COG0200	Binds to the 23S rRNA
SL003B_RS08900	COG0201	protein transport
SL003B_RS08905	COG0563	adenylate kinase activity
SL003B_RS08910	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SL003B_RS08915	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SL003B_RS08920	COG0202	RNA polymerase activity
SL003B_RS08925	COG0203	ribosomal protein L17
SL003B_RS08935	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SL003B_RS08940	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SL003B_RS08950	COG1752	Esterase of the alpha-beta hydrolase superfamily
SL003B_RS08970	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SL003B_RS08975	COG0564	pseudouridine synthase activity
SL003B_RS08985	COG0546	phosphoglycolate phosphatase activity
SL003B_RS09000	COG1305	Transglutaminase-like
SL003B_RS09010	COG2308	Evidence 4 Homologs of previously reported genes of
SL003B_RS09015	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SL003B_RS09040	COG4770	biotin carboxylase activity
SL003B_RS09050	COG3706	GGDEF domain
SL003B_RS09055	COG1254	Belongs to the acylphosphatase family
SL003B_RS09070	COG1090	epimerase
SL003B_RS09075	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SL003B_RS09095	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SL003B_RS09110	COG2239	Acts as a magnesium transporter
SL003B_RS09135	COG1960	acyl-CoA dehydrogenase activity
SL003B_RS09165	COG0740	serine-type endopeptidase activity
SL003B_RS09175	COG0656	L-ascorbic acid biosynthetic process
SL003B_RS09190	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
SL003B_RS09220	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SL003B_RS09230	COG0484	heat shock protein binding
SL003B_RS09235	COG1686	Belongs to the peptidase S11 family
SL003B_RS09245	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SL003B_RS09270	COG0537	adenosine 5'-monophosphoramidase activity
SL003B_RS09305	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SL003B_RS09320	COG0784	Response regulator, receiver
SL003B_RS09325	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SL003B_RS09340	COG0557	exoribonuclease II activity
SL003B_RS09345	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SL003B_RS09350	COG0758	DNA mediated transformation
SL003B_RS09355	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SL003B_RS09360	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SL003B_RS09365	COG0540	Belongs to the ATCase OTCase family
SL003B_RS09370	COG1960	acyl-CoA dehydrogenase activity
SL003B_RS09380	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SL003B_RS09385	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SL003B_RS09395	COG1028	Short-chain dehydrogenase reductase Sdr
SL003B_RS09405	COG1250	3-hydroxyacyl-CoA dehydrogenase
SL003B_RS09405	COG1024	Enoyl-CoA hydratase
SL003B_RS09425	COG0583	DNA-binding transcription factor activity
SL003B_RS09435	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SL003B_RS09440	COG1917	Cupin 2, conserved barrel domain protein
SL003B_RS09470	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
SL003B_RS09485	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
SL003B_RS09490	COG3639	organic phosphonate transmembrane transporter activity
SL003B_RS09505	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
SL003B_RS09510	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
SL003B_RS09515	COG3639	organic phosphonate transmembrane transporter activity
SL003B_RS09520	COG3639	organic phosphonate transmembrane transporter activity
SL003B_RS09525	COG2951	lytic endotransglycosylase activity
SL003B_RS09535	COG2373	Large extracellular alpha-helical protein
SL003B_RS09540	COG4953	penicillin-binding protein 1C
SL003B_RS09560	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SL003B_RS09570	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SL003B_RS09575	COG1381	Involved in DNA repair and RecF pathway recombination
SL003B_RS09580	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SL003B_RS09585	COG0571	ribonuclease III activity
SL003B_RS09590	COG0681	Belongs to the peptidase S26 family
SL003B_RS09595	COG0736	holo-[acyl-carrier-protein] synthase activity
SL003B_RS09615	COG1758	RNA polymerase activity
SL003B_RS09625	COG1573	uracil-dna glycosylase
SL003B_RS09635	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
SL003B_RS09640	COG3273	potassium ion transport
SL003B_RS09640	COG0471	metal ion transport
SL003B_RS09650	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SL003B_RS09655	COG0113	porphobilinogen synthase activity
SL003B_RS09660	COG1960	acyl-CoA dehydrogenase activity
SL003B_RS09685	COG2989	Protein conserved in bacteria
SL003B_RS09695	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SL003B_RS09700	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SL003B_RS09705	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SL003B_RS09705	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SL003B_RS09715	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SL003B_RS09725	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
SL003B_RS09730	COG2814	Major facilitator Superfamily
SL003B_RS09735	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
SL003B_RS09755	COG0416	fatty acid biosynthetic process
SL003B_RS09760	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SL003B_RS09765	COG0776	regulation of translation
SL003B_RS09790	COG0297	glycogen (starch) synthase activity
SL003B_RS09795	COG1596	polysaccharide export
SL003B_RS09820	COG1612	heme a metabolic process
SL003B_RS09845	COG0306	phosphate transporter
SL003B_RS09870	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SL003B_RS09870	COG0446	pyridine nucleotide-disulphide oxidoreductase
SL003B_RS09880	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SL003B_RS09890	COG2124	cytochrome p450
SL003B_RS09900	COG0339	signal peptide processing
SL003B_RS09905	COG1802	Transcriptional regulator
SL003B_RS09930	COG1335	isochorismatase
SL003B_RS09935	COG3845	ABC transporter
SL003B_RS09945	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SL003B_RS09950	COG1079	Belongs to the binding-protein-dependent transport system permease family
SL003B_RS09995	COG3971	2-oxopent-4-enoate hydratase activity
SL003B_RS10000	COG0179	Fumarylacetoacetate (FAA) hydrolase
SL003B_RS10010	COG3384	dioxygenase
SL003B_RS10025	COG1846	Transcriptional regulator
SL003B_RS10040	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
SL003B_RS10045	COG1278	Cold shock
SL003B_RS10055	COG1253	flavin adenine dinucleotide binding
SL003B_RS10120	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
SL003B_RS10130	COG0671	phosphoesterase, PA-phosphatase related
SL003B_RS10135	COG0463	Glycosyl transferase, family 2
SL003B_RS10145	COG0626	cystathionine gamma-synthase activity
SL003B_RS10150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SL003B_RS10155	COG4597	amino acid ABC transporter
SL003B_RS10160	COG0765	amino acid transport
SL003B_RS10165	COG1126	abc transporter atp-binding protein
SL003B_RS10175	COG2897	thiosulfate sulfurtransferase activity
SL003B_RS10180	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SL003B_RS10190	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SL003B_RS10200	COG3806	Anti-sigma factor
SL003B_RS10205	COG4221	oxidoreductase activity
SL003B_RS10210	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SL003B_RS10230	COG0156	8-amino-7-oxononanoate synthase activity
SL003B_RS10235	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
SL003B_RS10245	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SL003B_RS10245	COG1116	anion transmembrane transporter activity
SL003B_RS10290	COG1492	cobalamin metabolic process
SL003B_RS10295	COG2226	methyltransferase
SL003B_RS10300	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
SL003B_RS10315	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SL003B_RS10330	COG0525	valine-tRNA ligase activity
SL003B_RS10350	COG0511	ligase activity, forming carbon-carbon bonds
SL003B_RS10355	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SL003B_RS10365	COG0501	Belongs to the peptidase M48B family
SL003B_RS10370	COG0436	Aminotransferase
SL003B_RS10375	COG1530	ribonuclease E activity
SL003B_RS10380	COG0860	N-Acetylmuramoyl-L-alanine amidase
SL003B_RS10395	COG0739	heme binding
SL003B_RS10400	COG2833	Protein of unknown function (DUF455)
SL003B_RS10405	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SL003B_RS10415	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SL003B_RS10420	COG0174	glutamine synthetase
SL003B_RS10425	COG0347	Belongs to the P(II) protein family
SL003B_RS10430	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SL003B_RS10430	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
SL003B_RS10440	COG0544	peptidyl-prolyl cis-trans isomerase activity
SL003B_RS10445	COG0740	serine-type endopeptidase activity
SL003B_RS10450	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SL003B_RS10455	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SL003B_RS10460	COG0776	regulation of translation
SL003B_RS10480	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SL003B_RS10485	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SL003B_RS10490	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SL003B_RS10495	COG0649	NAD binding
SL003B_RS10510	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
SL003B_RS10520	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SL003B_RS10530	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SL003B_RS10555	COG1007	ATP synthesis coupled electron transport
SL003B_RS10570	COG0346	lactoylglutathione lyase activity
SL003B_RS10580	COG0442	prolyl-tRNA aminoacylation
SL003B_RS10590	COG1136	(ABC) transporter
SL003B_RS10600	COG0052	Belongs to the universal ribosomal protein uS2 family
SL003B_RS10605	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SL003B_RS10615	COG0233	cytoplasmic translational termination
SL003B_RS10620	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SL003B_RS10630	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SL003B_RS10635	COG0750	zinc metalloprotease
SL003B_RS10640	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SL003B_RS10645	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SL003B_RS10650	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SL003B_RS10655	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SL003B_RS10660	COG3494	Protein of unknown function (DUF1009)
SL003B_RS10665	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SL003B_RS10670	COG0372	Belongs to the citrate synthase family
SL003B_RS10685	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SL003B_RS10690	COG0535	radical SAM domain protein
SL003B_RS10755	COG2197	response regulator
SL003B_RS10785	COG3383	formate dehydrogenase (NAD+) activity
SL003B_RS10800	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
SL003B_RS10805	COG1473	amidohydrolase
SL003B_RS10810	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
SL003B_RS10835	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SL003B_RS10845	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SL003B_RS10845	COG1116	anion transmembrane transporter activity
SL003B_RS10860	COG3396	Phenylacetate-CoA oxygenase
SL003B_RS10865	COG3460	Phenylacetate-CoA oxygenase
SL003B_RS10870	COG3396	Phenylacetate-CoA oxygenase
SL003B_RS10875	COG2151	metal-sulfur cluster biosynthetic enzyme
SL003B_RS10880	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SL003B_RS10890	COG2030	dehydratase
SL003B_RS10890	COG1012	belongs to the aldehyde dehydrogenase family
SL003B_RS10905	COG2050	protein possibly involved in aromatic compounds catabolism
SL003B_RS10910	COG1024	Enoyl-CoA hydratase
SL003B_RS10960	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SL003B_RS10965	COG1120	ATPase activity
SL003B_RS10975	COG0811	peptide transport
SL003B_RS11015	COG0747	negative chemotaxis
SL003B_RS11040	COG0303	'Molybdopterin
SL003B_RS11045	COG0315	cyclic pyranopterin monophosphate synthase activity
SL003B_RS11050	COG0134	indole-3-glycerol-phosphate synthase activity
SL003B_RS11055	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SL003B_RS11065	COG0149	triose-phosphate isomerase activity
SL003B_RS11075	COG0504	CTP synthase activity
SL003B_RS11090	COG1472	Belongs to the glycosyl hydrolase 3 family
SL003B_RS11095	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
SL003B_RS11100	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
SL003B_RS11105	COG3842	ATPase activity
SL003B_RS11110	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SL003B_RS11115	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SL003B_RS11120	COG0805	protein transport
SL003B_RS11125	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SL003B_RS11135	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SL003B_RS11150	COG1862	Preprotein translocase
SL003B_RS11155	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SL003B_RS11175	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
SL003B_RS11185	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SL003B_RS11190	COG0629	single-stranded DNA binding
SL003B_RS11205	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SL003B_RS11210	COG2095	MarC family integral membrane protein
SL003B_RS11215	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SL003B_RS11230	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SL003B_RS11250	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SL003B_RS11270	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SL003B_RS11280	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SL003B_RS11285	COG0148	phosphopyruvate hydratase activity
SL003B_RS11320	COG2301	Belongs to the HpcH HpaI aldolase family
SL003B_RS11330	COG0679	Auxin Efflux Carrier
SL003B_RS11335	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SL003B_RS11345	COG1183	phosphatidylcholine synthase activity
SL003B_RS11355	COG0583	DNA-binding transcription factor activity
SL003B_RS11360	COG2351	hydroxyisourate hydrolase activity
SL003B_RS11370	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SL003B_RS11375	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
SL003B_RS11375	COG3608	succinylglutamate desuccinylase aspartoacylase
SL003B_RS11380	COG3845	ABC transporter
SL003B_RS11390	COG1079	Belongs to the binding-protein-dependent transport system permease family
SL003B_RS11415	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SL003B_RS11445	COG0811	peptide transport
SL003B_RS11455	COG1629	transport
SL003B_RS11465	COG4558	Periplasmic binding protein
SL003B_RS11470	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SL003B_RS11475	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
SL003B_RS11480	COG2133	pyrroloquinoline quinone binding
SL003B_RS11485	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SL003B_RS11500	COG2963	transposase activity
SL003B_RS11505	COG2801	Transposase and inactivated derivatives
SL003B_RS11525	COG1686	Belongs to the peptidase S11 family
SL003B_RS11530	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SL003B_RS11545	COG0084	hydrolase, TatD family'
SL003B_RS11550	COG1234	tRNA 3'-trailer cleavage
SL003B_RS11560	COG2137	regulation of response to DNA damage stimulus
SL003B_RS11570	COG1309	transcriptional regulator
SL003B_RS11575	COG1309	transcriptional regulator
SL003B_RS11580	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SL003B_RS11600	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
SL003B_RS11605	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SL003B_RS11610	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SL003B_RS11615	COG3956	TIGRFAM MazG family protein
SL003B_RS11620	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SL003B_RS11625	COG1923	regulation of RNA biosynthetic process
SL003B_RS11630	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SL003B_RS11635	COG0569	domain protein
SL003B_RS11640	COG2204	response regulator
SL003B_RS11645	COG5000	phosphorelay sensor kinase activity
SL003B_RS11650	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SL003B_RS11655	COG1129	ABC transporter
SL003B_RS11655	COG0842	Transport permease protein
SL003B_RS11660	COG0842	Transport permease protein
SL003B_RS11665	COG2204	response regulator
SL003B_RS11680	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SL003B_RS11680	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
SL003B_RS11685	COG1546	Belongs to the CinA family
SL003B_RS11700	COG2867	negative regulation of translational initiation
SL003B_RS11705	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SL003B_RS11720	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SL003B_RS11730	COG0022	dehydrogenase e1 component
SL003B_RS11730	COG0508	dehydrogenase complex catalyzes the overall conversion of
SL003B_RS11735	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SL003B_RS11745	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SL003B_RS11750	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
SL003B_RS11755	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SL003B_RS11770	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SL003B_RS11775	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SL003B_RS11785	COG0785	Cytochrome C biogenesis protein
SL003B_RS11800	COG0243	molybdopterin cofactor binding
SL003B_RS11820	COG0640	Transcriptional regulator
SL003B_RS11825	COG0701	Predicted permease
SL003B_RS11840	COG1028	Short-chain dehydrogenase reductase Sdr
SL003B_RS11865	COG0018	arginyl-trna synthetase
SL003B_RS11870	COG0232	Belongs to the dGTPase family. Type 2 subfamily
SL003B_RS11875	COG0316	Belongs to the HesB IscA family
SL003B_RS11890	COG0187	DNA topoisomerase II activity
SL003B_RS11905	COG0513	Belongs to the DEAD box helicase family
SL003B_RS11915	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
SL003B_RS11920	COG0316	Belongs to the HesB IscA family
SL003B_RS11925	COG2151	metal-sulfur cluster biosynthetic enzyme
SL003B_RS11930	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SL003B_RS11935	COG0719	Fe-S assembly protein
SL003B_RS11940	COG0396	ATPase activity
SL003B_RS11945	COG0719	Fe-S assembly protein
SL003B_RS11950	COG1104	cysteine desulfurase activity
SL003B_RS11955	COG2945	thiolester hydrolase activity
SL003B_RS11965	COG5002	protein histidine kinase activity
SL003B_RS11965	COG2205	protein histidine kinase activity
SL003B_RS11965	COG0784	Response regulator, receiver
SL003B_RS11970	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SL003B_RS11975	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SL003B_RS11980	COG2200	EAL domain
SL003B_RS11985	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SL003B_RS12000	COG1132	(ABC) transporter
SL003B_RS12005	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SL003B_RS12010	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
SL003B_RS12020	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
SL003B_RS12030	COG0628	permease
SL003B_RS12035	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SL003B_RS12040	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SL003B_RS12045	COG0243	molybdopterin cofactor binding
SL003B_RS12050	COG0105	UTP biosynthetic process
SL003B_RS12060	COG0488	(ABC) transporter
SL003B_RS12065	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SL003B_RS12075	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SL003B_RS12105	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SL003B_RS12110	COG0194	GDP metabolic process
SL003B_RS12115	COG1561	YicC-like family, N-terminal region
SL003B_RS12120	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SL003B_RS12125	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SL003B_RS12130	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SL003B_RS12140	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SL003B_RS12145	COG0360	Binds together with S18 to 16S ribosomal RNA
SL003B_RS12150	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SL003B_RS12160	COG0305	Participates in initiation and elongation during chromosome replication
SL003B_RS12165	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SL003B_RS12175	COG1286	toxin biosynthetic process
SL003B_RS12180	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SL003B_RS12185	COG4221	oxidoreductase activity
SL003B_RS12190	COG1160	GTP binding
SL003B_RS12195	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SL003B_RS12225	COG1175	transmembrane transport
SL003B_RS12230	COG1653	transport
SL003B_RS12240	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
SL003B_RS12250	COG3842	ATPase activity
SL003B_RS12265	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SL003B_RS12265	COG0519	Catalyzes the synthesis of GMP from XMP
SL003B_RS12280	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SL003B_RS12280	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SL003B_RS12290	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
SL003B_RS12325	COG1904	glucuronate isomerase
SL003B_RS12330	COG4608	Belongs to the ABC transporter superfamily
SL003B_RS12335	COG0444	Belongs to the ABC transporter superfamily
SL003B_RS12340	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SL003B_RS12345	COG0601	transmembrane transport
SL003B_RS12360	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SL003B_RS12365	COG3959	Transketolase, thiamine diphosphate binding domain
SL003B_RS12370	COG3958	Transketolase
SL003B_RS12375	COG2084	Dehydrogenase
SL003B_RS12380	COG1024	Enoyl-CoA hydratase
SL003B_RS12395	COG0402	S-adenosylhomocysteine deaminase activity
SL003B_RS12405	COG3845	ABC transporter
SL003B_RS12410	COG4603	Belongs to the binding-protein-dependent transport system permease family
SL003B_RS12415	COG1079	Belongs to the binding-protein-dependent transport system permease family
SL003B_RS12420	COG0402	S-adenosylhomocysteine deaminase activity
SL003B_RS12425	COG0095	Lipoate-protein ligase
SL003B_RS12435	COG0022	dehydrogenase e1 component
SL003B_RS12440	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SL003B_RS12455	COG0402	S-adenosylhomocysteine deaminase activity
SL003B_RS12475	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SL003B_RS12515	COG1414	Transcriptional regulator
SL003B_RS12525	COG0431	NADPH-dependent FMN reductase
SL003B_RS12540	COG1132	(ABC) transporter
SL003B_RS12555	COG0641	radical SAM
SL003B_RS12575	COG1802	Transcriptional regulator
SL003B_RS12580	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
SL003B_RS12585	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
SL003B_RS12590	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
SL003B_RS12590	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
SL003B_RS12595	COG1312	Catalyzes the dehydration of D-mannonate
SL003B_RS12635	COG1082	Xylose isomerase domain protein TIM barrel
SL003B_RS12635	COG3185	4-Hydroxyphenylpyruvate dioxygenase
SL003B_RS12640	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
SL003B_RS12650	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SL003B_RS12675	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SL003B_RS12680	COG1024	Enoyl-CoA hydratase
SL003B_RS12690	COG0183	Belongs to the thiolase family
SL003B_RS12700	COG1022	Amp-dependent synthetase and ligase
SL003B_RS12730	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SL003B_RS12735	COG1053	succinate dehydrogenase
SL003B_RS12740	COG0028	Belongs to the TPP enzyme family
SL003B_RS12770	COG1012	belongs to the aldehyde dehydrogenase family
SL003B_RS12820	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SL003B_RS12820	COG0512	Glutamine amidotransferase of anthranilate synthase
SL003B_RS12855	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SL003B_RS12890	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SL003B_RS12920	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SL003B_RS12920	COG4651	solute:proton antiporter activity
SL003B_RS12935	COG1017	nitric oxide dioxygenase activity
SL003B_RS12935	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SL003B_RS12975	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
SL003B_RS13055	COG2801	Transposase and inactivated derivatives
SL003B_RS13060	COG2963	transposase activity
SL003B_RS13120	COG0625	glutathione transferase activity
SL003B_RS13125	COG0456	acetyltransferase
SL003B_RS13145	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SL003B_RS13175	COG2943	transferase activity, transferring hexosyl groups
SL003B_RS13185	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
SL003B_RS13195	COG0154	amidase activity
SL003B_RS13200	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SL003B_RS13220	COG1067	ATP-dependent peptidase activity
SL003B_RS13260	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SL003B_RS13270	COG0446	pyridine nucleotide-disulphide oxidoreductase
SL003B_RS13275	COG1294	oxidase, subunit
SL003B_RS13280	COG1271	oxidase subunit
SL003B_RS13285	COG1959	2 iron, 2 sulfur cluster binding
SL003B_RS13290	COG1363	Peptidase, m42
SL003B_RS13295	COG0189	ligase activity
SL003B_RS13295	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SL003B_RS13300	COG0367	asparagine synthase
SL003B_RS13325	COG1176	ABC-type spermidine putrescine transport system, permease component I
SL003B_RS13335	COG3842	ATPase activity
SL003B_RS13340	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SL003B_RS13345	COG0006	proline dipeptidase activity
SL003B_RS13355	COG1802	Transcriptional regulator
SL003B_RS13365	COG0235	Class ii aldolase
SL003B_RS13370	COG1940	carbohydrate kinase activity
SL003B_RS13385	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SL003B_RS13400	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SL003B_RS13415	COG0436	Aminotransferase
SL003B_RS13425	COG3243	poly(R)-hydroxyalkanoic acid synthase
SL003B_RS13435	COG0010	Belongs to the arginase family
SL003B_RS13440	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SL003B_RS13445	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SL003B_RS13455	COG0129	dihydroxy-acid dehydratase activity
SL003B_RS13460	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SL003B_RS13480	COG1846	Transcriptional regulator
SL003B_RS13485	COG1764	response to oxidative stress
SL003B_RS13505	COG1234	tRNA 3'-trailer cleavage
SL003B_RS13510	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SL003B_RS13510	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SL003B_RS13515	COG1132	(ABC) transporter
SL003B_RS13535	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SL003B_RS13545	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
SL003B_RS13550	COG2391	methyltransferase activity
SL003B_RS13575	COG0785	Cytochrome C biogenesis protein
SL003B_RS13595	COG3258	Cytochrome c
SL003B_RS13610	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SL003B_RS13615	COG3258	Cytochrome c
SL003B_RS13625	COG0446	pyridine nucleotide-disulphide oxidoreductase
SL003B_RS13635	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SL003B_RS13640	COG1121	(ABC) transporter
SL003B_RS13655	COG0175	sulfate reduction
SL003B_RS13670	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
SL003B_RS13675	COG0583	DNA-binding transcription factor activity
SL003B_RS13685	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SL003B_RS13690	COG3485	protocatechuate 3,4-dioxygenase
SL003B_RS13695	COG3485	protocatechuate 3,4-dioxygenase
SL003B_RS13700	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
SL003B_RS13705	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
SL003B_RS13720	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SL003B_RS13725	COG4977	sequence-specific DNA binding
SL003B_RS13725	COG1917	Cupin 2, conserved barrel domain protein
SL003B_RS13740	COG1695	Transcriptional regulator
SL003B_RS13745	COG1566	PFAM secretion protein HlyD family protein
SL003B_RS13760	COG0688	phosphatidylethanolamine metabolic process
SL003B_RS13765	COG5265	(ABC) transporter
SL003B_RS13775	COG1652	LysM domain
SL003B_RS13785	COG2962	Rard protein
SL003B_RS13790	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SL003B_RS13800	COG0215	cysteine-tRNA ligase activity
SL003B_RS13805	COG2989	Protein conserved in bacteria
SL003B_RS13815	COG0640	Transcriptional regulator
SL003B_RS13820	COG3045	CreA protein
SL003B_RS13850	COG0745	RESPONSE REGULATOR receiver
SL003B_RS13855	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
SL003B_RS13870	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SL003B_RS13875	COG5001	Diguanylate cyclase
SL003B_RS13890	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
SL003B_RS13900	COG0546	phosphoglycolate phosphatase activity
SL003B_RS13915	COG0840	transmembrane signaling receptor activity
SL003B_RS13930	COG1028	Short-chain dehydrogenase reductase Sdr
SL003B_RS13935	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SL003B_RS13950	COG2089	acid synthase
SL003B_RS13970	COG2759	Belongs to the formate--tetrahydrofolate ligase family
SL003B_RS13975	COG5012	cobalamin binding
SL003B_RS13990	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
SL003B_RS13995	COG0646	methionine synthase
SL003B_RS13995	COG1410	methionine synthase
SL003B_RS14010	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SL003B_RS14035	COG5598	trimethylamine methyltransferase
SL003B_RS14040	COG1028	Short-chain dehydrogenase reductase Sdr
SL003B_RS14040	COG0604	alcohol dehydrogenase
SL003B_RS14040	COG3321	synthase
SL003B_RS14045	COG0156	8-amino-7-oxononanoate synthase activity
SL003B_RS14075	COG2942	2-epimerase
SL003B_RS14080	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SL003B_RS14100	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
SL003B_RS14110	COG5001	Diguanylate cyclase
SL003B_RS14110	COG3300	MHYT domain
SL003B_RS14125	COG3038	cytochrome b561
SL003B_RS14140	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
SL003B_RS14140	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
SL003B_RS14145	COG1376	ErfK ybiS ycfS ynhG family protein
SL003B_RS14155	COG0415	Belongs to the DNA photolyase family
SL003B_RS14160	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SL003B_RS14165	COG2814	Major facilitator Superfamily
SL003B_RS14190	COG0746	molybdenum cofactor guanylyltransferase activity
SL003B_RS14200	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SL003B_RS14215	COG2084	Dehydrogenase
SL003B_RS14225	COG1522	sequence-specific DNA binding
SL003B_RS14235	COG1573	uracil-dna glycosylase
SL003B_RS14240	COG2202	Pas domain
SL003B_RS14240	COG2205	protein histidine kinase activity
SL003B_RS14245	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SL003B_RS14250	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
SL003B_RS14270	COG0730	response to heat
SL003B_RS14275	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SL003B_RS14280	COG3639	organic phosphonate transmembrane transporter activity
SL003B_RS14285	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
SL003B_RS14305	COG1203	CRISPR-associated helicase, Cas3
SL003B_RS14335	COG1518	maintenance of DNA repeat elements
SL003B_RS14350	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SL003B_RS14355	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
SL003B_RS14365	COG0583	DNA-binding transcription factor activity
SL003B_RS14375	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
SL003B_RS14390	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
SL003B_RS14395	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SL003B_RS14440	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
SL003B_RS14455	COG1024	Enoyl-CoA hydratase
SL003B_RS14460	COG0318	PFAM AMP-dependent synthetase and ligase
SL003B_RS14460	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SL003B_RS14460	COG1028	Short-chain dehydrogenase reductase Sdr
SL003B_RS14460	COG3321	synthase
SL003B_RS14460	COG0300	oxidoreductase activity
SL003B_RS14470	COG1960	acyl-CoA dehydrogenase activity
SL003B_RS14480	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
SL003B_RS14485	COG4988	ABC transporter
SL003B_RS14505	COG1741	Belongs to the pirin family
SL003B_RS14515	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SL003B_RS14520	COG0747	negative chemotaxis
SL003B_RS14530	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SL003B_RS14535	COG4172	Belongs to the ABC transporter superfamily
SL003B_RS14545	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SL003B_RS14550	COG0601	transmembrane transport
SL003B_RS14555	COG0747	negative chemotaxis
SL003B_RS14565	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
SL003B_RS14570	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SL003B_RS14580	COG0308	aminopeptidase N
SL003B_RS14585	COG5642	Protein of unknown function (DUF2384)
SL003B_RS14595	COG2202	Pas domain
SL003B_RS14595	COG2205	protein histidine kinase activity
SL003B_RS14610	COG2205	protein histidine kinase activity
SL003B_RS14620	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SL003B_RS14640	COG3088	subunit of a heme lyase
SL003B_RS14645	COG1138	Cytochrome C-type biogenesis protein
SL003B_RS14650	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
SL003B_RS14655	COG4235	cytochrome complex assembly
SL003B_RS14770	COG4695	Portal protein
SL003B_RS14795	COG0069	glutamate synthase activity
SL003B_RS14800	COG0346	lactoylglutathione lyase activity
SL003B_RS14805	COG0400	carboxylic ester hydrolase activity
SL003B_RS14815	COG2983	Belongs to the UPF0260 family
SL003B_RS14820	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
SL003B_RS14860	COG2205	protein histidine kinase activity
SL003B_RS14870	COG2166	iron-sulfur cluster assembly
SL003B_RS14890	COG4957	zinc ion binding
SL003B_RS14895	COG1320	monovalent cation:proton antiporter activity
SL003B_RS14900	COG2212	antiporter activity
SL003B_RS14905	COG1863	multisubunit Na H antiporter MnhE subunit
SL003B_RS14910	COG0651	ATP synthesis coupled electron transport
SL003B_RS14915	COG1006	Multisubunit Na H antiporter MnhC subunit
SL003B_RS14920	COG2111	Na H antiporter
SL003B_RS14925	COG2111	Na H antiporter
SL003B_RS14925	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SL003B_RS14930	COG0628	permease
SL003B_RS14935	COG5001	Diguanylate cyclase
SL003B_RS14935	COG4251	negative regulation of phosphorylation
SL003B_RS14935	COG2203	Gaf domain
SL003B_RS14935	COG3706	GGDEF domain
SL003B_RS14940	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SL003B_RS14945	COG1733	regulation of RNA biosynthetic process
SL003B_RS14950	COG0702	epimerase
SL003B_RS14955	COG2271	Major facilitator Superfamily
SL003B_RS14985	COG2010	Cytochrome c
SL003B_RS14995	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SL003B_RS15005	COG0477	Major facilitator Superfamily
SL003B_RS15050	COG0433	COG0433 Predicted ATPase
SL003B_RS15075	COG1703	isobutyryl-CoA mutase activity
SL003B_RS15095	COG0436	Aminotransferase
SL003B_RS15105	COG5310	Homospermidine synthase
SL003B_RS15155	COG0659	secondary active sulfate transmembrane transporter activity
SL003B_RS15185	COG3608	succinylglutamate desuccinylase aspartoacylase
SL003B_RS15185	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
SL003B_RS15220	COG1028	Short-chain dehydrogenase reductase Sdr
SL003B_RS15235	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SL003B_RS15250	COG3206	protein involved in exopolysaccharide biosynthesis
SL003B_RS15250	COG0489	protein tyrosine kinase activity
SL003B_RS15285	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SL003B_RS15300	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SL003B_RS15300	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
SL003B_RS15330	COG0438	transferase activity, transferring glycosyl groups
SL003B_RS15355	COG0175	sulfate reduction
SL003B_RS15400	COG0840	transmembrane signaling receptor activity
SL003B_RS15405	COG5001	Diguanylate cyclase
SL003B_RS15405	COG3300	MHYT domain
SL003B_RS15410	COG0346	lactoylglutathione lyase activity
SL003B_RS15455	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
SL003B_RS15480	COG2813	Specifically methylates the guanine in position
SL003B_RS15485	COG1187	pseudouridine synthase activity
SL003B_RS15490	COG0488	(ABC) transporter
SL003B_RS15495	COG1802	Transcriptional regulator
SL003B_RS15505	COG1376	ErfK ybiS ycfS ynhG family protein
SL003B_RS15510	COG1272	protein, Hemolysin III
SL003B_RS15520	COG0318	PFAM AMP-dependent synthetase and ligase
SL003B_RS15535	COG1902	pentaerythritol trinitrate reductase activity
SL003B_RS15540	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
SL003B_RS15565	COG3842	ATPase activity
SL003B_RS15590	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SL003B_RS15605	COG1116	anion transmembrane transporter activity
SL003B_RS15610	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SL003B_RS15630	COG0737	Belongs to the 5'-nucleotidase family
SL003B_RS15635	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
SL003B_RS15640	COG0424	maF-like protein
SL003B_RS15645	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SL003B_RS15655	COG5328	Belongs to the UPF0262 family
SL003B_RS15670	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SL003B_RS15685	COG1349	DNA-binding transcription factor activity
SL003B_RS15695	COG1335	isochorismatase
SL003B_RS15705	COG1176	ABC-type spermidine putrescine transport system, permease component I
SL003B_RS15710	COG3842	ATPase activity
SL003B_RS15725	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
SL003B_RS15735	COG1414	Transcriptional regulator
SL003B_RS15740	COG0028	Belongs to the TPP enzyme family
SL003B_RS15750	COG1028	Short-chain dehydrogenase reductase Sdr
SL003B_RS15815	COG0683	leucine binding
SL003B_RS15820	COG3384	dioxygenase
SL003B_RS15835	COG0583	DNA-binding transcription factor activity
SL003B_RS15865	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SL003B_RS15900	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SL003B_RS15915	COG1012	belongs to the aldehyde dehydrogenase family
SL003B_RS15920	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SL003B_RS15925	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SL003B_RS15930	COG0765	amino acid transport
SL003B_RS15935	COG1126	abc transporter atp-binding protein
SL003B_RS15945	COG1250	3-hydroxyacyl-CoA dehydrogenase
SL003B_RS15945	COG1024	Enoyl-CoA hydratase
SL003B_RS15950	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
SL003B_RS15955	COG0583	DNA-binding transcription factor activity
SL003B_RS15960	COG2124	cytochrome p450
SL003B_RS15970	COG1028	Short-chain dehydrogenase reductase Sdr
SL003B_RS15975	COG0129	dihydroxy-acid dehydratase activity
SL003B_RS16020	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SL003B_RS16035	COG0583	DNA-binding transcription factor activity
SL003B_RS16055	COG0659	secondary active sulfate transmembrane transporter activity
SL003B_RS16060	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SL003B_RS16065	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
SL003B_RS16095	COG0483	inositol monophosphate 1-phosphatase activity
SL003B_RS16105	COG0395	ABC-type sugar transport system, permease component
SL003B_RS16110	COG1176	ABC-type spermidine putrescine transport system, permease component I
SL003B_RS16120	COG3842	ATPase activity
SL003B_RS16130	COG2186	Transcriptional regulator
SL003B_RS16135	COG3250	beta-galactosidase activity
SL003B_RS16145	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
SL003B_RS16145	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
SL003B_RS16160	COG0246	Mannitol dehydrogenase
SL003B_RS16185	COG2217	Heavy metal translocating P-type atpase
SL003B_RS16200	COG2010	Cytochrome c
SL003B_RS16215	COG3278	Belongs to the heme-copper respiratory oxidase family
SL003B_RS16225	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SL003B_RS16235	COG0784	Response regulator, receiver
SL003B_RS16235	COG2205	protein histidine kinase activity
SL003B_RS16235	COG2198	Histidine kinase
SL003B_RS16240	COG4566	intracellular signal transduction
SL003B_RS16245	COG4191	Histidine kinase
SL003B_RS16250	COG0436	Aminotransferase
SL003B_RS16255	COG1970	mechanosensitive ion channel activity
SL003B_RS16260	COG3850	Histidine kinase
SL003B_RS16260	COG5002	protein histidine kinase activity
SL003B_RS16270	COG0432	Pfam Uncharacterised protein family UPF0047
SL003B_RS16275	COG0657	acetylesterase activity
SL003B_RS16295	COG1793	dna ligase
SL003B_RS16300	COG0513	Belongs to the DEAD box helicase family
SL003B_RS16315	COG1793	dna ligase
SL003B_RS16315	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
SL003B_RS16320	COG1201	RNA secondary structure unwinding
SL003B_RS16330	COG0667	Aldo Keto reductase
SL003B_RS16340	COG0730	response to heat
SL003B_RS16345	COG3501	Rhs element vgr protein
SL003B_RS16345	COG3409	Peptidoglycan-binding domain 1 protein
SL003B_RS16355	COG1960	acyl-CoA dehydrogenase activity
SL003B_RS16370	COG0183	Belongs to the thiolase family
SL003B_RS16375	COG1250	3-hydroxyacyl-CoA dehydrogenase
SL003B_RS16375	COG1024	Enoyl-CoA hydratase
SL003B_RS16400	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
SL003B_RS16420	COG0717	Belongs to the dCTP deaminase family
SL003B_RS16430	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SL003B_RS16435	COG2967	ApaG domain
SL003B_RS16445	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
SL003B_RS16465	COG0167	dihydroorotate dehydrogenase activity
SL003B_RS16470	COG0534	Mate efflux family protein
SL003B_RS16515	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SL003B_RS16520	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SL003B_RS16530	COG0745	RESPONSE REGULATOR receiver
SL003B_RS16535	COG0704	Plays a role in the regulation of phosphate uptake
SL003B_RS16540	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SL003B_RS16550	COG0573	inorganic phosphate transmembrane transporter activity
SL003B_RS16570	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SL003B_RS16580	COG0318	PFAM AMP-dependent synthetase and ligase
SL003B_RS16585	COG0546	phosphoglycolate phosphatase activity
SL003B_RS16590	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SL003B_RS16595	COG0598	Magnesium transport protein CorA
SL003B_RS16600	COG0259	pyridoxamine-phosphate oxidase activity
SL003B_RS16610	COG0484	heat shock protein binding
SL003B_RS16620	COG1960	acyl-CoA dehydrogenase activity
SL003B_RS16625	COG0009	L-threonylcarbamoyladenylate synthase
SL003B_RS16630	COG0123	including yeast histone deacetylase and acetoin utilization protein
SL003B_RS16635	COG1722	exodeoxyribonuclease VII activity
SL003B_RS16665	COG1999	signal sequence binding
SL003B_RS16670	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
SL003B_RS16685	COG2226	methyltransferase
SL003B_RS16695	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SL003B_RS16700	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SL003B_RS16700	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SL003B_RS16735	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
SL003B_RS16740	COG0277	FAD linked oxidase domain protein
SL003B_RS16750	COG2135	peptidase activity
SL003B_RS16760	COG1051	belongs to the nudix hydrolase family
SL003B_RS16800	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SL003B_RS16810	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
SL003B_RS16835	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
SL003B_RS16840	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SL003B_RS16850	COG0751	glycine-tRNA ligase activity
SL003B_RS16860	COG1704	LemA family
SL003B_RS16865	COG0752	glycyl-tRNA synthetase alpha subunit
SL003B_RS16895	COG1573	uracil-dna glycosylase
SL003B_RS16905	COG0513	Belongs to the DEAD box helicase family
SL003B_RS16910	COG0280	phosphate acetyltransferase
SL003B_RS16910	COG0281	malic enzyme
SL003B_RS16920	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SL003B_RS16925	COG0521	Mo-molybdopterin cofactor biosynthetic process
SL003B_RS16940	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SL003B_RS16945	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SL003B_RS16950	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SL003B_RS16955	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SL003B_RS16960	COG0356	it plays a direct role in the translocation of protons across the membrane
SL003B_RS16970	COG1196	nuclear chromosome segregation
SL003B_RS16975	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
SL003B_RS16990	COG3128	pkhd-type hydroxylase
SL003B_RS17005	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SL003B_RS17015	COG2189	Belongs to the N(4) N(6)-methyltransferase family
SL003B_RS17020	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SL003B_RS17030	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SL003B_RS17035	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SL003B_RS17045	COG0509	glycine decarboxylation via glycine cleavage system
SL003B_RS17050	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SL003B_RS17060	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SL003B_RS17065	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
SL003B_RS17070	COG0328	RNA-DNA hybrid ribonuclease activity
SL003B_RS17075	COG1597	lipid kinase activity
SL003B_RS17080	COG5001	Diguanylate cyclase
SL003B_RS17090	COG0612	Peptidase, M16
SL003B_RS17100	COG1678	Uncharacterized ACR, COG1678
SL003B_RS17130	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
SL003B_RS17135	COG0109	protoheme IX farnesyltransferase activity
SL003B_RS17140	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SL003B_RS17145	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SL003B_RS17170	COG0312	modulator of DNA gyrase
SL003B_RS17195	COG1663	tetraacyldisaccharide 4'-kinase activity
SL003B_RS17200	COG1519	Transferase
SL003B_RS17215	COG0483	inositol monophosphate 1-phosphatase activity
SL003B_RS17220	COG0312	modulator of DNA gyrase
SL003B_RS17235	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SL003B_RS17255	COG0596	Alpha beta hydrolase
SL003B_RS17270	COG1752	Esterase of the alpha-beta hydrolase superfamily
SL003B_RS17285	COG0590	tRNA wobble adenosine to inosine editing
SL003B_RS17290	COG1187	pseudouridine synthase activity
SL003B_RS17295	COG0742	ribosomal rna small subunit methyltransferase
SL003B_RS17320	COG3300	MHYT domain
SL003B_RS17320	COG5001	Diguanylate cyclase
SL003B_RS17345	COG0745	RESPONSE REGULATOR receiver
SL003B_RS17350	COG2030	dehydratase
SL003B_RS17360	COG0196	riboflavin kinase activity
SL003B_RS17365	COG0697	spore germination
SL003B_RS17375	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SL003B_RS17380	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SL003B_RS17390	COG0612	Peptidase, M16
SL003B_RS17395	COG0612	Peptidase, M16
SL003B_RS17405	COG2204	response regulator
SL003B_RS17420	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SL003B_RS17425	COG0459	protein refolding
SL003B_RS17435	COG2900	Belongs to the SlyX family
SL003B_RS17470	COG2346	COG2346, Truncated hemoglobins
SL003B_RS17480	COG0124	histidyl-tRNA synthetase
SL003B_RS17490	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SL003B_RS17495	COG2818	Glycosylase
SL003B_RS17510	COG1376	ErfK ybiS ycfS ynhG family protein
SL003B_RS17520	COG0247	lactate metabolic process
SL003B_RS17530	COG0277	FAD linked oxidase domain protein
SL003B_RS17535	COG0277	FAD linked oxidase domain protein
SL003B_RS17540	COG0583	DNA-binding transcription factor activity
SL003B_RS17555	COG2186	Transcriptional regulator
SL003B_RS17560	COG0247	lactate metabolic process
SL003B_RS17565	COG1139	Iron-sulfur cluster binding protein
SL003B_RS17570	COG1556	Lactate utilization protein
SL003B_RS17585	COG0583	DNA-binding transcription factor activity
SL003B_RS17610	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SL003B_RS17615	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SL003B_RS17630	COG1570	exodeoxyribonuclease VII activity
SL003B_RS17640	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
SL003B_RS17655	COG0028	Belongs to the TPP enzyme family
SL003B_RS17660	COG1652	LysM domain
SL003B_RS17665	COG0071	Belongs to the small heat shock protein (HSP20) family
SL003B_RS17690	COG0730	response to heat
SL003B_RS17720	COG2205	protein histidine kinase activity
SL003B_RS17730	COG1840	ABC-type Fe3 transport system, periplasmic component
SL003B_RS17750	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
SL003B_RS17755	COG1177	transmembrane transport
SL003B_RS17760	COG1176	ABC-type spermidine putrescine transport system, permease component I
SL003B_RS17765	COG3842	ATPase activity
SL003B_RS17775	COG0174	glutamine synthetase
SL003B_RS17785	COG0174	glutamine synthetase
SL003B_RS17795	COG1012	belongs to the aldehyde dehydrogenase family
SL003B_RS17815	COG0175	sulfate reduction
SL003B_RS17820	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SL003B_RS17830	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SL003B_RS17830	COG1648	precorrin-2 dehydrogenase activity
SL003B_RS17835	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SL003B_RS17840	COG0463	Glycosyl transferase, family 2
SL003B_RS17855	COG1671	Belongs to the UPF0178 family
SL003B_RS17890	COG0596	Alpha beta hydrolase
SL003B_RS17895	COG1278	Cold shock
SL003B_RS17920	COG1309	transcriptional regulator
SL003B_RS17950	COG0174	glutamine synthetase
SL003B_RS17965	COG1012	belongs to the aldehyde dehydrogenase family
SL003B_RS17990	COG4175	Glycine betaine
SL003B_RS18005	COG1309	transcriptional regulator
SL003B_RS18010	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
SL003B_RS18015	COG1012	belongs to the aldehyde dehydrogenase family
SL003B_RS18020	COG2081	HI0933 family
SL003B_RS18030	COG1959	2 iron, 2 sulfur cluster binding
SL003B_RS18045	COG0683	leucine binding
SL003B_RS18055	COG0559	Belongs to the binding-protein-dependent transport system permease family
SL003B_RS18080	COG3483	tryptophan 2,3-dioxygenase activity
SL003B_RS18090	COG1802	Transcriptional regulator
SL003B_RS18095	COG1760	l-serine dehydratase
SL003B_RS18100	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
SL003B_RS18105	COG1802	Transcriptional regulator
SL003B_RS18110	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
SL003B_RS18205	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
SL003B_RS18240	COG1569	PIN domain
SL003B_RS18245	COG3311	Transcriptional regulator
SL003B_RS18255	COG4227	nucleotidyltransferase activity
SL003B_RS18285	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SL003B_RS18325	COG0230	Belongs to the bacterial ribosomal protein bL34 family
SL003B_RS18330	COG0594	ribonuclease P activity
SL003B_RS18335	COG0706	membrane insertase activity
SL003B_RS18345	COG0218	Necessary for normal cell division and for the maintenance of normal septation
SL003B_RS18350	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SL003B_RS18360	COG0583	DNA-binding transcription factor activity
SL003B_RS18370	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SL003B_RS18385	COG2171	N-acyltransferase activity
SL003B_RS18395	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SL003B_RS18410	COG0101	tRNA pseudouridine synthase activity
SL003B_RS18425	COG0242	peptide deformylase activity
SL003B_RS18435	COG0791	NLP P60 protein
SL003B_RS18445	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SL003B_RS18480	COG4964	Belongs to the GSP D family
SL003B_RS18500	COG4964	Belongs to the GSP D family
SL003B_RS18520	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SL003B_RS18545	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SL003B_RS18555	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SL003B_RS18565	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SL003B_RS18575	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SL003B_RS18585	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
SL003B_RS18590	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
SL003B_RS18595	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
SL003B_RS18605	COG0295	cytidine deaminase activity
SL003B_RS18610	COG1079	Belongs to the binding-protein-dependent transport system permease family
SL003B_RS18615	COG1079	Belongs to the binding-protein-dependent transport system permease family
SL003B_RS18620	COG3845	ABC transporter
SL003B_RS18625	COG1744	ABC transporter substrate-binding protein PnrA-like
SL003B_RS18645	COG1803	Methylglyoxal synthase
SL003B_RS18650	COG0837	glucose binding
SL003B_RS18655	COG1643	Atp-dependent helicase
SL003B_RS18660	COG0653	protein targeting
SL003B_RS18670	COG1522	sequence-specific DNA binding
SL003B_RS18675	COG4134	Bacterial extracellular solute-binding protein
SL003B_RS18680	COG4135	transport system, permease component
SL003B_RS18685	COG4136	ATPase activity
SL003B_RS18700	COG1028	Short-chain dehydrogenase reductase Sdr
SL003B_RS18740	COG0116	Belongs to the methyltransferase superfamily
SL003B_RS18740	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SL003B_RS18760	COG0840	transmembrane signaling receptor activity
SL003B_RS18765	COG1278	Cold shock
SL003B_RS18770	COG1032	radical SAM domain protein
SL003B_RS18780	COG0840	transmembrane signaling receptor activity
SL003B_RS18795	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
SL003B_RS18800	COG3621	Patatin-like phospholipase
SL003B_RS18805	COG1363	Peptidase, m42
SL003B_RS18820	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
SL003B_RS18845	COG0121	glutamine amidotransferase
SL003B_RS18850	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SL003B_RS18865	COG0501	Belongs to the peptidase M48B family
SL003B_RS18905	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
SL003B_RS18950	COG3609	addiction module antidote protein, CC2985 family
SL003B_RS18985	COG1475	DNA binding
SL003B_RS19020	COG3547	Transposase (IS116 IS110 IS902 family)
SL003B_RS19155	COG2132	Multicopper oxidase
SL003B_RS19175	COG1024	Enoyl-CoA hydratase
SL003B_RS19180	COG1960	acyl-CoA dehydrogenase activity
SL003B_RS19185	COG1846	Transcriptional regulator
SL003B_RS19195	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
SL003B_RS19215	COG0411	ABC transporter
SL003B_RS19230	COG0318	PFAM AMP-dependent synthetase and ligase
SL003B_RS19240	COG0747	negative chemotaxis
SL003B_RS19245	COG0601	transmembrane transport
SL003B_RS19250	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SL003B_RS19255	COG0444	Belongs to the ABC transporter superfamily
SL003B_RS19270	COG2204	response regulator
SL003B_RS19285	COG0179	Fumarylacetoacetate (FAA) hydrolase
SL003B_RS19330	COG0066	3-isopropylmalate dehydratase activity
SL003B_RS19335	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SL003B_RS19365	COG2188	Transcriptional regulator
SL003B_RS19380	COG1177	transmembrane transport
SL003B_RS19385	COG1176	ABC-type spermidine putrescine transport system, permease component I
SL003B_RS19390	COG3842	ATPase activity
SL003B_RS19395	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
SL003B_RS19400	COG0583	DNA-binding transcription factor activity
SL003B_RS19415	COG1157	protein secretion by the type III secretion system
SL003B_RS19425	COG4786	Flagellar basal body rod
SL003B_RS19435	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
SL003B_RS19450	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SL003B_RS19455	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SL003B_RS19460	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
SL003B_RS19490	COG1684	flagellar biosynthetic protein fliR
SL003B_RS19495	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
SL003B_RS19525	COG5443	negative regulation of bacterial-type flagellum assembly
SL003B_RS19565	COG1360	Flagellar Motor Protein
SL003B_RS19585	COG1338	Plays a role in the flagellum-specific transport system
SL003B_RS19605	COG1706	bacterial-type flagellum-dependent cell motility
SL003B_RS19610	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
SL003B_RS19615	COG4786	Flagellar basal body rod
SL003B_RS19620	COG1677	Flagellar hook-basal body complex protein FliE
SL003B_RS19625	COG1558	bacterial-type flagellum-dependent cell motility
SL003B_RS19635	COG0443	Heat shock 70 kDa protein
SL003B_RS19695	COG1797	cobyrinic acid a,c-diamide synthase activity
SL003B_RS19705	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
SL003B_RS19730	COG0438	transferase activity, transferring glycosyl groups
SL003B_RS19740	COG0438	transferase activity, transferring glycosyl groups
SL003B_RS19750	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
SL003B_RS19770	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SL003B_RS19775	COG1960	acyl-CoA dehydrogenase activity
SL003B_RS19780	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SL003B_RS19785	COG3038	cytochrome b561
SL003B_RS19790	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SL003B_RS19790	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SL003B_RS19800	COG0438	transferase activity, transferring glycosyl groups
SL003B_RS19815	COG2943	transferase activity, transferring hexosyl groups
SL003B_RS19820	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SL003B_RS19825	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
SL003B_RS19830	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
SL003B_RS19835	COG1137	ATPase activity
SL003B_RS19850	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SL003B_RS19870	COG2378	regulation of single-species biofilm formation
SL003B_RS19875	COG2197	response regulator
SL003B_RS19880	COG3800	Transcriptional regulator
SL003B_RS19880	COG1396	sequence-specific DNA binding
SL003B_RS19885	COG0251	oxidation-reduction process
SL003B_RS19895	COG2268	Band 7 protein
SL003B_RS19900	COG1012	belongs to the aldehyde dehydrogenase family
SL003B_RS19930	COG1012	belongs to the aldehyde dehydrogenase family
SL003B_RS19990	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
SL003B_RS19995	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
SL003B_RS20115	COG4397	Mu-like prophage major head subunit gpT
SL003B_RS20135	COG4383	Mu-like prophage protein gp29
SL003B_RS20140	COG4373	Mu-like prophage FluMu protein gp28
SL003B_RS20260	COG2217	Heavy metal translocating P-type atpase
SL003B_RS20275	COG2217	Heavy metal translocating P-type atpase
SL003B_RS20290	COG1477	protein flavinylation
SL003B_RS20310	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SL003B_RS20460	COG1475	DNA binding
SL003B_RS20490	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SL003B_RS20610	COG3328	transposase activity
SL003B_RS20625	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SL003B_RS20665	COG2146	nitrite reductase [NAD(P)H] activity
SL003B_RS20730	COG0625	glutathione transferase activity
SL003B_RS20740	COG2963	transposase activity
SL003B_RS20745	COG3436	PFAM IS66 Orf2 family protein
SL003B_RS20750	COG4372	Transposase
SL003B_RS20795	COG1475	DNA binding
SL003B_RS20830	COG3609	addiction module antidote protein, CC2985 family
SL003B_RS20855	COG5001	Diguanylate cyclase
SL003B_RS20875	COG1116	anion transmembrane transporter activity
SL003B_RS20900	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SL003B_RS20905	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SL003B_RS20925	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SL003B_RS20930	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SL003B_RS20935	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SL003B_RS20940	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SL003B_RS20945	COG0799	negative regulation of ribosome biogenesis
SL003B_RS20950	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
SL003B_RS20960	COG0793	Belongs to the peptidase S41A family
SL003B_RS20970	COG0494	nUDIX hydrolase
SL003B_RS20975	COG1028	Short-chain dehydrogenase reductase Sdr
SL003B_RS20985	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SL003B_RS20995	COG1968	undecaprenyl-diphosphatase activity
SL003B_RS21020	COG3685	Protein conserved in bacteria
SL003B_RS21030	COG0028	Belongs to the TPP enzyme family
SL003B_RS21035	COG2391	methyltransferase activity
SL003B_RS21055	COG0071	Belongs to the small heat shock protein (HSP20) family
SL003B_RS21075	COG3842	ATPase activity
SL003B_RS21080	COG0395	ABC-type sugar transport system, permease component
SL003B_RS21120	COG0539	negative regulation of cytoplasmic translation
SL003B_RS21125	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SL003B_RS21135	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SL003B_RS21140	COG0616	signal peptide processing
SL003B_RS21145	COG0776	regulation of translation
SL003B_RS21160	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SL003B_RS21170	COG1074	ATP-dependent DNA helicase activity
SL003B_RS21180	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SL003B_RS21185	COG3178	'Phosphotransferase
SL003B_RS21190	COG2205	protein histidine kinase activity
SL003B_RS21200	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SL003B_RS21205	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SL003B_RS21205	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
SL003B_RS21215	COG2205	protein histidine kinase activity
SL003B_RS21220	COG0745	RESPONSE REGULATOR receiver
SL003B_RS21225	COG0534	Mate efflux family protein
SL003B_RS21230	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
SL003B_RS21240	COG1280	lysine exporter protein (LysE YggA)
SL003B_RS21245	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
SL003B_RS21245	COG3608	succinylglutamate desuccinylase aspartoacylase
SL003B_RS21250	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SL003B_RS21260	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SL003B_RS21265	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SL003B_RS21270	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SL003B_RS21275	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SL003B_RS21280	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SL003B_RS21290	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SL003B_RS21295	COG4974	Belongs to the 'phage' integrase family
SL003B_RS21300	COG1278	Cold shock
SL003B_RS21310	COG0828	Belongs to the bacterial ribosomal protein bS21 family
SL003B_RS21330	COG0789	Transcriptional regulator
SL003B_RS21335	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SL003B_RS21340	COG0508	dehydrogenase complex catalyzes the overall conversion of
SL003B_RS21350	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
SL003B_RS21355	COG0045	succinate-CoA ligase (ADP-forming) activity
SL003B_RS21360	COG0039	L-malate dehydrogenase activity
SL003B_RS21365	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
SL003B_RS21415	COG0514	ATP-dependent DNA helicase (RecQ)
SL003B_RS21420	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SL003B_RS21425	COG0180	Tryptophanyl-tRNA synthetase
SL003B_RS21435	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
SL003B_RS21450	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
SL003B_RS21460	COG3030	protein affecting phage T7 exclusion by the F plasmid
SL003B_RS21470	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SL003B_RS21470	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SL003B_RS21510	COG0671	phosphoesterase, PA-phosphatase related
SL003B_RS21520	COG4122	O-methyltransferase activity
SL003B_RS21525	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
SL003B_RS21530	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SL003B_RS21540	COG0583	DNA-binding transcription factor activity
SL003B_RS21545	COG1960	acyl-CoA dehydrogenase activity
SL003B_RS21555	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SL003B_RS21565	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SL003B_RS21595	COG2020	methyltransferase activity
SL003B_RS21605	COG2816	NAD+ diphosphatase activity
SL003B_RS21615	COG4172	Belongs to the ABC transporter superfamily
SL003B_RS21620	COG4239	(ABC) transporter, permease
SL003B_RS21625	COG4174	ABC transporter (Permease)
SL003B_RS21630	COG4166	transmembrane transport
SL003B_RS21635	COG4166	transmembrane transport
SL003B_RS21645	COG3474	cytochrome
SL003B_RS21650	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
SL003B_RS21655	COG1605	Chorismate mutase
SL003B_RS21655	COG0077	Prephenate dehydratase
SL003B_RS21660	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SL003B_RS21665	COG0588	phosphoglycerate mutase activity
SL003B_RS21670	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SL003B_RS21675	COG1185	polyribonucleotide nucleotidyltransferase activity
SL003B_RS21680	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SL003B_RS21690	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SL003B_RS21695	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SL003B_RS21700	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SL003B_RS21715	COG0779	Required for maturation of 30S ribosomal subunits
SL003B_RS21720	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SL003B_RS21725	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SL003B_RS21730	COG1396	sequence-specific DNA binding
SL003B_RS21735	COG0815	Transfers the fatty acyl group on membrane lipoproteins
SL003B_RS21740	COG1253	flavin adenine dinucleotide binding
SL003B_RS21745	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SL003B_RS21755	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SL003B_RS21770	COG0456	acetyltransferase
SL003B_RS21775	COG1214	PFAM Peptidase M22, glycoprotease
SL003B_RS21790	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
SL003B_RS21795	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
SL003B_RS21805	COG3963	phosphatidate phosphatase activity
SL003B_RS21810	COG0484	heat shock protein binding
SL003B_RS21820	COG0443	Heat shock 70 kDa protein
SL003B_RS21830	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SL003B_RS21835	COG2226	methyltransferase
SL003B_RS21845	COG1024	Enoyl-CoA hydratase
SL003B_RS21850	COG0268	Binds directly to 16S ribosomal RNA
SL003B_RS21970	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SL003B_RS22125	COG0133	tryptophan synthase activity
SL003B_RS22160	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SL003B_RS22200	COG1749	Flagellar hook protein flgE
SL003B_RS22210	COG2771	luxR family
SL003B_RS22230	COG0508	dehydrogenase complex catalyzes the overall conversion of
SL003B_RS22230	COG0022	dehydrogenase e1 component
SL003B_RS22245	COG5001	Diguanylate cyclase
SL003B_RS22245	COG3300	MHYT domain
SL003B_RS22285	COG3706	GGDEF domain
SL003B_RS22300	COG2264	protein methyltransferase activity
SL003B_RS22340	COG2205	protein histidine kinase activity
SL003B_RS22345	COG2365	Tyrosine phosphatase family
SL003B_RS22350	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SL003B_RS22350	COG0248	Ppx GppA phosphatase
SL003B_RS22360	COG1250	3-hydroxyacyl-CoA dehydrogenase
SL003B_RS22360	COG1024	Enoyl-CoA hydratase
SL003B_RS22385	COG1309	transcriptional regulator
SL003B_RS22440	COG2819	hydrolase of the alpha beta superfamily
SL003B_RS22540	COG1442	glycosyl transferase family 8
SL003B_RS22540	COG1216	Glycosyl transferase, family 2