locus-tag	class	description
PNEC_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
PNEC_RS00010	COG0592	DNA-directed DNA polymerase activity
PNEC_RS00030	COG0411	ABC transporter
PNEC_RS00060	COG0445	tRNA wobble uridine modification
PNEC_RS00065	COG0357	Ribosomal RNA small subunit methyltransferase G
PNEC_RS00070	COG1192	Involved in chromosome partitioning
PNEC_RS00085	COG0356	it plays a direct role in the translocation of protons across the membrane
PNEC_RS00095	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
PNEC_RS00100	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
PNEC_RS00105	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
PNEC_RS00110	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
PNEC_RS00115	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
PNEC_RS00120	COG0355	proton-transporting ATP synthase activity, rotational mechanism
PNEC_RS00125	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
PNEC_RS00130	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
PNEC_RS00135	COG0509	glycine decarboxylation via glycine cleavage system
PNEC_RS00170	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
PNEC_RS00175	COG2823	Periplasmic or secreted lipoprotein
PNEC_RS00230	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
PNEC_RS00240	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
PNEC_RS00250	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
PNEC_RS00255	COG0081	regulation of translation
PNEC_RS00260	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
PNEC_RS00265	COG0222	ribosome binding
PNEC_RS00270	COG0085	RNA polymerase activity
PNEC_RS00275	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
PNEC_RS00280	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
PNEC_RS00285	COG0049	tRNA binding
PNEC_RS00290	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
PNEC_RS00295	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
PNEC_RS00300	COG0051	transcription antitermination factor activity, RNA binding
PNEC_RS00305	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
PNEC_RS00310	COG0088	Forms part of the polypeptide exit tunnel
PNEC_RS00315	COG0089	rRNA binding
PNEC_RS00320	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
PNEC_RS00325	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
PNEC_RS00330	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
PNEC_RS00335	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
PNEC_RS00340	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
PNEC_RS00345	COG0255	Belongs to the universal ribosomal protein uL29 family
PNEC_RS00350	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
PNEC_RS00355	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
PNEC_RS00360	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
PNEC_RS00365	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
PNEC_RS00370	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
PNEC_RS00375	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
PNEC_RS00380	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
PNEC_RS00385	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
PNEC_RS00390	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
PNEC_RS00395	COG1841	ribosomal large subunit assembly
PNEC_RS00400	COG0200	Binds to the 23S rRNA
PNEC_RS00405	COG0201	protein transport
PNEC_RS00410	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
PNEC_RS00415	COG0257	Belongs to the bacterial ribosomal protein bL36 family
PNEC_RS00420	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
PNEC_RS00425	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
PNEC_RS00430	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
PNEC_RS00435	COG0202	RNA polymerase activity
PNEC_RS00440	COG0203	ribosomal protein L17
PNEC_RS00445	COG1324	tolerance protein
PNEC_RS00450	COG4232	protein-disulfide reductase activity
PNEC_RS00455	COG0113	porphobilinogen synthase activity
PNEC_RS00460	COG0218	Necessary for normal cell division and for the maintenance of normal septation
PNEC_RS00470	COG0019	diaminopimelate decarboxylase activity
PNEC_RS00475	COG1965	Belongs to the frataxin family
PNEC_RS00480	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
PNEC_RS00530	COG1127	ABC transporter
PNEC_RS00535	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
PNEC_RS00540	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
PNEC_RS00545	COG2853	Lipoprotein
PNEC_RS00570	COG5007	Belongs to the BolA IbaG family
PNEC_RS00575	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
PNEC_RS00585	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
PNEC_RS00595	COG0131	Imidazoleglycerol-phosphate dehydratase
PNEC_RS00600	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
PNEC_RS00605	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
PNEC_RS00610	COG0107	imidazoleglycerol-phosphate synthase activity
PNEC_RS00615	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
PNEC_RS00620	COG0140	phosphoribosyl-ATP diphosphatase activity
PNEC_RS00630	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
PNEC_RS00635	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
PNEC_RS00640	COG0805	protein transport
PNEC_RS00650	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
PNEC_RS00695	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PNEC_RS00700	COG1970	mechanosensitive ion channel activity
PNEC_RS00705	COG0723	plastoquinol--plastocyanin reductase activity
PNEC_RS00710	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
PNEC_RS00715	COG2857	Cytochrome c1
PNEC_RS00720	COG0625	glutathione transferase activity
PNEC_RS00765	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
PNEC_RS00775	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
PNEC_RS00780	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
PNEC_RS00790	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
PNEC_RS00800	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
PNEC_RS00805	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PNEC_RS00810	COG0012	GTP binding
PNEC_RS00825	COG0134	indole-3-glycerol-phosphate synthase activity
PNEC_RS00830	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
PNEC_RS00835	COG0512	Glutamine amidotransferase of anthranilate synthase
PNEC_RS00850	COG2967	ApaG domain
PNEC_RS00875	COG0156	8-amino-7-oxononanoate synthase activity
PNEC_RS00890	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
PNEC_RS00900	COG0275	rRNA processing
PNEC_RS00915	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
PNEC_RS00920	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
PNEC_RS00925	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
PNEC_RS00930	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
PNEC_RS00935	COG0772	Belongs to the SEDS family
PNEC_RS00940	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
PNEC_RS00945	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
PNEC_RS00950	COG1181	Belongs to the D-alanine--D-alanine ligase family
PNEC_RS00955	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
PNEC_RS00965	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
PNEC_RS00970	COG0678	peroxiredoxin activity
PNEC_RS00975	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
PNEC_RS00985	COG0653	protein targeting
PNEC_RS01005	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
PNEC_RS01020	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
PNEC_RS01035	COG1459	type II secretion system
PNEC_RS01045	COG4536	flavin adenine dinucleotide binding
PNEC_RS01080	COG0142	geranyltranstransferase activity
PNEC_RS01085	COG0261	This protein binds to 23S rRNA in the presence of protein L20
PNEC_RS01090	COG0211	Belongs to the bacterial ribosomal protein bL27 family
PNEC_RS01095	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
PNEC_RS01100	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
PNEC_RS01110	COG0494	nUDIX hydrolase
PNEC_RS01115	COG0442	prolyl-tRNA aminoacylation
PNEC_RS01120	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
PNEC_RS01140	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
PNEC_RS01165	COG2264	protein methyltransferase activity
PNEC_RS01170	COG0439	Biotin carboxylase
PNEC_RS01175	COG0511	ligase activity, forming carbon-carbon bonds
PNEC_RS01180	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
PNEC_RS01185	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PNEC_RS01190	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
PNEC_RS01195	COG1028	Short-chain dehydrogenase reductase Sdr
PNEC_RS01200	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
PNEC_RS01210	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
PNEC_RS01215	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
PNEC_RS01220	COG0284	orotidine-5'-phosphate decarboxylase activity
PNEC_RS01235	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
PNEC_RS01255	COG1385	rRNA (uridine-N3-)-methyltransferase activity
PNEC_RS01260	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
PNEC_RS01265	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
PNEC_RS01270	COG0735	belongs to the Fur family
PNEC_RS01275	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
PNEC_RS01280	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
PNEC_RS01285	COG0495	leucyl-tRNA aminoacylation
PNEC_RS01300	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
PNEC_RS01305	COG1981	membrane
PNEC_RS01315	COG1773	rubredoxin
PNEC_RS01320	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
PNEC_RS01325	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
PNEC_RS01330	COG0415	Belongs to the DNA photolyase family
PNEC_RS01335	COG1678	Uncharacterized ACR, COG1678
PNEC_RS01340	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
PNEC_RS01345	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
PNEC_RS01350	COG0540	Belongs to the ATCase OTCase family
PNEC_RS01425	COG1968	undecaprenyl-diphosphatase activity
PNEC_RS01440	COG0220	tRNA (guanine-N7-)-methyltransferase activity
PNEC_RS01450	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
PNEC_RS01455	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
PNEC_RS01490	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PNEC_RS01490	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PNEC_RS01515	COG0823	Involved in the tonB-independent uptake of proteins
PNEC_RS01535	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
PNEC_RS01540	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
PNEC_RS01545	COG0563	adenylate kinase activity
PNEC_RS01550	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
PNEC_RS01555	COG2835	tetraacyldisaccharide 4'-kinase activity
PNEC_RS01560	COG1663	tetraacyldisaccharide 4'-kinase activity
PNEC_RS01565	COG0848	biopolymer transport protein
PNEC_RS01570	COG0811	peptide transport
PNEC_RS01575	COG1570	exodeoxyribonuclease VII activity
PNEC_RS01585	COG0812	UDP-N-acetylmuramate dehydrogenase activity
PNEC_RS01590	COG1666	GTP binding
PNEC_RS01595	COG4974	Belongs to the 'phage' integrase family
PNEC_RS01600	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
PNEC_RS01660	COG1028	Short-chain dehydrogenase reductase Sdr
PNEC_RS01665	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
PNEC_RS01675	COG0028	Belongs to the TPP enzyme family
PNEC_RS01690	COG0463	Glycosyl transferase, family 2
PNEC_RS01735	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
PNEC_RS01765	COG0640	Transcriptional regulator
PNEC_RS01790	COG3530	Putative quorum-sensing-regulated virulence factor
PNEC_RS01800	COG0741	lytic transglycosylase activity
PNEC_RS01830	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
PNEC_RS01900	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
PNEC_RS01910	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
PNEC_RS01925	COG0303	'Molybdopterin
PNEC_RS01930	COG0746	molybdenum cofactor guanylyltransferase activity
PNEC_RS01940	COG1530	ribonuclease E activity
PNEC_RS01950	COG0546	phosphoglycolate phosphatase activity
PNEC_RS01960	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
PNEC_RS01965	COG0424	maF-like protein
PNEC_RS01975	COG0333	Belongs to the bacterial ribosomal protein bL32 family
PNEC_RS01980	COG0416	fatty acid biosynthetic process
PNEC_RS01985	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
PNEC_RS01995	COG1028	Short-chain dehydrogenase reductase Sdr
PNEC_RS02000	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PNEC_RS02005	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PNEC_RS02010	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PNEC_RS02015	COG0481	GTPase activity
PNEC_RS02020	COG0681	Belongs to the peptidase S26 family
PNEC_RS02025	COG0571	ribonuclease III activity
PNEC_RS02030	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
PNEC_RS02035	COG1381	Involved in DNA repair and RecF pathway recombination
PNEC_RS02045	COG0736	holo-[acyl-carrier-protein] synthase activity
PNEC_RS02050	COG1472	Belongs to the glycosyl hydrolase 3 family
PNEC_RS02065	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
PNEC_RS02075	COG0322	excinuclease ABC activity
PNEC_RS02100	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
PNEC_RS02110	COG0360	Binds together with S18 to 16S ribosomal RNA
PNEC_RS02120	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
PNEC_RS02125	COG0359	binds to the 23S rRNA
PNEC_RS02140	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
PNEC_RS02145	COG0726	polysaccharide deacetylase
PNEC_RS02150	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PNEC_RS02150	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
PNEC_RS02155	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
PNEC_RS02155	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PNEC_RS02165	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
PNEC_RS02170	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
PNEC_RS02205	COG0314	molybdopterin synthase activity
PNEC_RS02215	COG2272	Belongs to the type-B carboxylesterase lipase family
PNEC_RS02220	COG2827	Endonuclease containing a URI domain
PNEC_RS02225	COG0542	response to heat
PNEC_RS02270	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
PNEC_RS02275	COG2878	Part of a membrane complex involved in electron transport
PNEC_RS02290	COG0556	nucleotide-excision repair
PNEC_RS02300	COG1104	cysteine desulfurase activity
PNEC_RS02305	COG0822	iron-sulfur transferase activity
PNEC_RS02315	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
PNEC_RS02320	COG0443	Heat shock 70 kDa protein
PNEC_RS02335	COG0175	sulfate reduction
PNEC_RS02355	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
PNEC_RS02360	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
PNEC_RS02365	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
PNEC_RS02370	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
PNEC_RS02390	COG1136	(ABC) transporter
PNEC_RS02395	COG0084	hydrolase, TatD family'
PNEC_RS02430	COG2890	protein-(glutamine-N5) methyltransferase activity
PNEC_RS02435	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
PNEC_RS02440	COG2171	N-acyltransferase activity
PNEC_RS02455	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
PNEC_RS02470	COG0024	Methionine aminopeptidase
PNEC_RS02475	COG0052	Belongs to the universal ribosomal protein uS2 family
PNEC_RS02480	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
PNEC_RS02485	COG0528	UMP kinase activity
PNEC_RS02490	COG0233	cytoplasmic translational termination
PNEC_RS02495	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
PNEC_RS02500	COG0575	Belongs to the CDS family
PNEC_RS02505	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
PNEC_RS02510	COG0750	zinc metalloprotease
PNEC_RS02525	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PNEC_RS02530	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
PNEC_RS02535	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PNEC_RS02540	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PNEC_RS02545	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
PNEC_RS02550	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PNEC_RS02560	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
PNEC_RS02565	COG2867	negative regulation of translational initiation
PNEC_RS02580	COG0518	GMP synthase (glutamine-hydrolyzing) activity
PNEC_RS02580	COG0519	Catalyzes the synthesis of GMP from XMP
PNEC_RS02585	COG2833	Protein of unknown function (DUF455)
PNEC_RS02610	COG0602	queuosine metabolic process
PNEC_RS02625	COG1619	proteins homologs of microcin C7 resistance protein MccF
PNEC_RS02680	COG1392	Phosphate transport regulator
PNEC_RS02685	COG0306	phosphate transporter
PNEC_RS02690	COG0489	protein tyrosine kinase activity
PNEC_RS02700	COG0437	4 iron, 4 sulfur cluster binding
PNEC_RS02725	COG3568	Endonuclease Exonuclease Phosphatase
PNEC_RS02745	COG1238	metal cluster binding
PNEC_RS02750	COG1028	Short-chain dehydrogenase reductase Sdr
PNEC_RS02760	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PNEC_RS02765	COG1902	pentaerythritol trinitrate reductase activity
PNEC_RS02775	COG3038	cytochrome b561
PNEC_RS02785	COG0697	spore germination
PNEC_RS02790	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
PNEC_RS02790	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
PNEC_RS02820	COG2081	HI0933 family
PNEC_RS02895	COG0824	Thioesterase
PNEC_RS02910	COG3585	molybdate ion transport
PNEC_RS02970	COG1024	Enoyl-CoA hydratase
PNEC_RS03005	COG0534	Mate efflux family protein
PNEC_RS03015	COG0254	rRNA binding
PNEC_RS03020	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
PNEC_RS03035	COG1074	ATP-dependent DNA helicase activity
PNEC_RS03045	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
PNEC_RS03050	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
PNEC_RS03055	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
PNEC_RS03085	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
PNEC_RS03100	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
PNEC_RS03110	COG0105	UTP biosynthetic process
PNEC_RS03115	COG0820	rRNA (adenine-C2-)-methyltransferase activity
PNEC_RS03120	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
PNEC_RS03125	COG0124	histidyl-tRNA synthetase
PNEC_RS03140	COG1160	GTP binding
PNEC_RS03145	COG1923	regulation of RNA biosynthetic process
PNEC_RS03155	COG0330	HflC and HflK could
PNEC_RS03160	COG0330	HflC and HflK could
PNEC_RS03165	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
PNEC_RS03170	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
PNEC_RS03175	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
PNEC_RS03205	COG0557	exoribonuclease II activity
PNEC_RS03210	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PNEC_RS03220	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
PNEC_RS03225	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
PNEC_RS03230	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
PNEC_RS03235	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
PNEC_RS03235	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
PNEC_RS03270	COG1546	Belongs to the CinA family
PNEC_RS03270	COG1058	Belongs to the CinA family
PNEC_RS03275	COG0174	glutamine synthetase
PNEC_RS03295	COG0339	signal peptide processing
PNEC_RS03300	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
PNEC_RS03340	COG0069	glutamate synthase activity
PNEC_RS03395	COG4968	Prepilin-type N-terminal cleavage methylation domain
PNEC_RS03490	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
PNEC_RS03500	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
PNEC_RS03555	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
PNEC_RS03565	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PNEC_RS03610	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
PNEC_RS03630	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
PNEC_RS03645	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PNEC_RS03705	COG0166	Belongs to the GPI family
PNEC_RS03735	COG0635	Involved in the biosynthesis of porphyrin-containing compound
PNEC_RS03755	COG0194	GDP metabolic process
PNEC_RS03760	COG1758	RNA polymerase activity
PNEC_RS03765	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
PNEC_RS03820	COG0028	Belongs to the TPP enzyme family
PNEC_RS03825	COG0440	acetolactate synthase activity
PNEC_RS03830	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
PNEC_RS03835	COG0688	phosphatidylethanolamine metabolic process
PNEC_RS03840	COG1183	phosphatidylcholine synthase activity
PNEC_RS03845	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
PNEC_RS03850	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
PNEC_RS03855	COG1185	polyribonucleotide nucleotidyltransferase activity
PNEC_RS03865	COG0149	triose-phosphate isomerase activity
PNEC_RS03870	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
PNEC_RS03880	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PNEC_RS03885	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PNEC_RS03890	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PNEC_RS03895	COG0649	NAD binding
PNEC_RS03900	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
PNEC_RS03910	COG1034	ATP synthesis coupled electron transport
PNEC_RS03915	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
PNEC_RS03920	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PNEC_RS03930	COG0713	ATP synthesis coupled electron transport
PNEC_RS03945	COG1007	ATP synthesis coupled electron transport
PNEC_RS03950	COG0494	nUDIX hydrolase
PNEC_RS03960	COG1902	pentaerythritol trinitrate reductase activity
PNEC_RS03965	COG0473	3-isopropylmalate dehydrogenase activity
PNEC_RS03975	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PNEC_RS03980	COG0328	RNA-DNA hybrid ribonuclease activity
PNEC_RS03985	COG2226	methyltransferase
PNEC_RS04000	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PNEC_RS04005	COG0505	Belongs to the CarA family
PNEC_RS04010	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
PNEC_RS04015	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
PNEC_RS04030	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
PNEC_RS04035	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PNEC_RS04045	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PNEC_RS04110	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
PNEC_RS04115	COG2814	Major facilitator Superfamily
PNEC_RS04130	COG2917	probably involved in intracellular septation
PNEC_RS04135	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
PNEC_RS04150	COG0354	folic acid binding
PNEC_RS04155	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
PNEC_RS04160	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
PNEC_RS04165	COG0470	DNA polymerase III
PNEC_RS04170	COG0084	hydrolase, TatD family'
PNEC_RS04220	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PNEC_RS04230	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
PNEC_RS04235	COG0148	phosphopyruvate hydratase activity
PNEC_RS04240	COG2877	3-deoxy-8-phosphooctulonate synthase activity
PNEC_RS04245	COG0504	CTP synthase activity
PNEC_RS04260	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
PNEC_RS04265	COG0047	phosphoribosylformylglycinamidine synthase activity
PNEC_RS04265	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
PNEC_RS04290	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
PNEC_RS04295	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
PNEC_RS04300	COG0740	serine-type endopeptidase activity
PNEC_RS04305	COG0544	peptidyl-prolyl cis-trans isomerase activity
PNEC_RS04320	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
PNEC_RS04325	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
PNEC_RS04330	COG0560	Phosphoserine phosphatase
PNEC_RS04335	COG0183	Belongs to the thiolase family
PNEC_RS04340	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
PNEC_RS04355	COG3243	poly(R)-hydroxyalkanoic acid synthase
PNEC_RS04360	COG1496	oxidoreductase activity
PNEC_RS04365	COG0564	pseudouridine synthase activity
PNEC_RS04375	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
PNEC_RS04390	COG0456	acetyltransferase
PNEC_RS04395	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
PNEC_RS04405	COG4770	biotin carboxylase activity
PNEC_RS04410	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
PNEC_RS04415	COG1703	isobutyryl-CoA mutase activity
PNEC_RS04420	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
PNEC_RS04420	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
PNEC_RS04425	COG1802	Transcriptional regulator
PNEC_RS04440	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
PNEC_RS04500	COG2022	thiamine diphosphate biosynthetic process
PNEC_RS04520	COG0826	peptidase U32
PNEC_RS04535	COG0204	Acyl-transferase
PNEC_RS04545	COG0318	PFAM AMP-dependent synthetase and ligase
PNEC_RS04555	COG1960	acyl-CoA dehydrogenase activity
PNEC_RS04560	COG1250	3-hydroxyacyl-CoA dehydrogenase
PNEC_RS04560	COG1024	Enoyl-CoA hydratase
PNEC_RS04565	COG0183	Belongs to the thiolase family
PNEC_RS04590	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
PNEC_RS04640	COG0825	malonyl-CoA metabolic process
PNEC_RS04650	COG0215	cysteine-tRNA ligase activity
PNEC_RS04665	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PNEC_RS04670	COG0483	inositol monophosphate 1-phosphatase activity
PNEC_RS04690	COG2850	peptidyl-arginine hydroxylation
PNEC_RS04695	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
PNEC_RS04700	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PNEC_RS04710	COG0180	Tryptophanyl-tRNA synthetase
PNEC_RS04715	COG0613	PHP domain protein
PNEC_RS04720	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
PNEC_RS04735	COG0567	Dehydrogenase, E1 component
PNEC_RS04765	COG0776	regulation of translation
PNEC_RS04770	COG0072	phenylalanine-tRNA ligase activity
PNEC_RS04770	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PNEC_RS04775	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
PNEC_RS04780	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
PNEC_RS04785	COG0291	Belongs to the bacterial ribosomal protein bL35 family
PNEC_RS04790	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
PNEC_RS04795	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
PNEC_RS04805	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
PNEC_RS04810	COG1230	cation diffusion facilitator family transporter
PNEC_RS04850	COG1960	acyl-CoA dehydrogenase activity
PNEC_RS04855	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
PNEC_RS04865	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PNEC_RS04865	COG3453	Protein conserved in bacteria
PNEC_RS04900	COG0737	Belongs to the 5'-nucleotidase family
PNEC_RS04940	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PNEC_RS04945	COG0500	methyltransferase
PNEC_RS04970	COG0285	dihydrofolate synthase activity
PNEC_RS04975	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
PNEC_RS04980	COG0159	tryptophan synthase activity
PNEC_RS04985	COG0133	tryptophan synthase activity
PNEC_RS04990	COG0135	phosphoribosylanthranilate isomerase activity
PNEC_RS04995	COG0101	tRNA pseudouridine synthase activity
PNEC_RS05010	COG0473	3-isopropylmalate dehydrogenase activity
PNEC_RS05015	COG0066	3-isopropylmalate dehydratase activity
PNEC_RS05025	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
PNEC_RS05030	COG0372	Belongs to the citrate synthase family
PNEC_RS05035	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
PNEC_RS05040	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
PNEC_RS05045	COG1053	succinate dehydrogenase
PNEC_RS05050	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
PNEC_RS05065	COG0039	L-malate dehydrogenase activity
PNEC_RS05080	COG3022	response to hydroperoxide
PNEC_RS05085	COG0436	Aminotransferase
PNEC_RS05090	COG1250	3-hydroxyacyl-CoA dehydrogenase
PNEC_RS05100	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
PNEC_RS05120	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
PNEC_RS05125	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
PNEC_RS05130	COG0167	dihydroorotate dehydrogenase activity
PNEC_RS05155	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PNEC_RS05160	COG0508	dehydrogenase complex catalyzes the overall conversion of
PNEC_RS05165	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
PNEC_RS05185	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
PNEC_RS05190	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
PNEC_RS05195	COG2251	uridine kinase activity
PNEC_RS05195	COG0195	Participates in both transcription termination and antitermination
PNEC_RS05200	COG0779	Required for maturation of 30S ribosomal subunits
PNEC_RS05210	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
PNEC_RS05220	COG0791	NLP P60 protein
PNEC_RS05225	COG4172	Belongs to the ABC transporter superfamily
PNEC_RS05230	COG4239	(ABC) transporter, permease
PNEC_RS05235	COG4174	ABC transporter (Permease)
PNEC_RS05240	COG4166	transmembrane transport
PNEC_RS05255	COG2301	Belongs to the HpcH HpaI aldolase family
PNEC_RS05325	COG0488	(ABC) transporter
PNEC_RS05335	COG3047	cAMP biosynthetic process
PNEC_RS05340	COG0635	Involved in the biosynthesis of porphyrin-containing compound
PNEC_RS05345	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
PNEC_RS05350	COG4681	YaeQ
PNEC_RS05365	COG2900	Belongs to the SlyX family
PNEC_RS05385	COG2824	Alkylphosphonate utilization operon protein PhnA
PNEC_RS05460	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
PNEC_RS05465	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
PNEC_RS05470	COG1674	ftsk spoiiie
PNEC_RS05475	COG0492	ferredoxin-NADP+ reductase activity
PNEC_RS05495	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
PNEC_RS05525	COG0129	dihydroxy-acid dehydratase activity
PNEC_RS05580	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
PNEC_RS05585	COG0308	aminopeptidase N
PNEC_RS05600	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
PNEC_RS05605	COG0259	pyridoxamine-phosphate oxidase activity
PNEC_RS05620	COG0513	Belongs to the DEAD box helicase family
PNEC_RS05635	COG0181	hydroxymethylbilane synthase activity
PNEC_RS05640	COG0165	Argininosuccinate lyase
PNEC_RS05665	COG0717	Belongs to the dCTP deaminase family
PNEC_RS05675	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PNEC_RS05675	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PNEC_RS05690	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
PNEC_RS05725	COG4206	TonB-dependent receptor
PNEC_RS05745	COG0730	response to heat
PNEC_RS05750	COG0318	PFAM AMP-dependent synthetase and ligase
PNEC_RS05775	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
PNEC_RS05785	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
PNEC_RS05815	COG0151	Belongs to the GarS family
PNEC_RS05825	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
PNEC_RS05830	COG0799	negative regulation of ribosome biogenesis
PNEC_RS05835	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
PNEC_RS05840	COG0424	maF-like protein
PNEC_RS05850	COG1132	(ABC) transporter
PNEC_RS05855	COG0463	Glycosyl transferase, family 2
PNEC_RS05860	COG1216	Glycosyl transferase, family 2
PNEC_RS05865	COG0859	PFAM glycosyl transferase family 9
PNEC_RS05880	COG0513	Belongs to the DEAD box helicase family
PNEC_RS05885	COG3193	protein, possibly involved in utilization of glycolate and propanediol
PNEC_RS05895	COG1802	Transcriptional regulator
PNEC_RS05915	COG0802	atpase or kinase
PNEC_RS05920	COG0860	N-Acetylmuramoyl-L-alanine amidase
PNEC_RS05930	COG0402	S-adenosylhomocysteine deaminase activity
PNEC_RS05970	COG1301	dicarboxylic acid transport
PNEC_RS05985	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
PNEC_RS05990	COG0312	modulator of DNA gyrase
PNEC_RS06000	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
PNEC_RS06005	COG0501	Belongs to the peptidase M48B family
PNEC_RS06010	COG1162	GTPase activity
PNEC_RS06015	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
PNEC_RS06025	COG0335	large ribosomal subunit rRNA binding
PNEC_RS06030	COG0336	Belongs to the RNA methyltransferase TrmD family
PNEC_RS06035	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
PNEC_RS06040	COG0228	four-way junction DNA binding
PNEC_RS06055	COG1960	acyl-CoA dehydrogenase activity
PNEC_RS06070	COG0318	PFAM AMP-dependent synthetase and ligase
PNEC_RS06080	COG2951	lytic endotransglycosylase activity
PNEC_RS06110	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PNEC_RS06115	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
PNEC_RS06125	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
PNEC_RS06130	COG0776	regulation of translation
PNEC_RS06140	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
PNEC_RS06145	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
PNEC_RS06150	COG0287	Prephenate dehydrogenase
PNEC_RS06155	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
PNEC_RS06165	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
PNEC_RS06180	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
PNEC_RS06195	COG3181	Tripartite tricarboxylate transporter family receptor
PNEC_RS06200	COG1054	Belongs to the UPF0176 family
PNEC_RS06235	COG3384	dioxygenase
PNEC_RS06240	COG1994	Peptidase M50
PNEC_RS06245	COG3909	cytochrome
PNEC_RS06275	COG2358	TRAP transporter, solute receptor (TAXI family
PNEC_RS06295	COG0739	heme binding
PNEC_RS06310	COG0659	secondary active sulfate transmembrane transporter activity
PNEC_RS06320	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PNEC_RS06335	COG0348	domain, Protein
PNEC_RS06355	COG3278	Belongs to the heme-copper respiratory oxidase family
PNEC_RS06365	COG2217	Heavy metal translocating P-type atpase
PNEC_RS06390	COG2358	TRAP transporter, solute receptor (TAXI family
PNEC_RS06400	COG4235	cytochrome complex assembly
PNEC_RS06405	COG3088	subunit of a heme lyase
PNEC_RS06410	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PNEC_RS06420	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
PNEC_RS06435	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
PNEC_RS06440	COG4133	protoheme IX ABC transporter activity
PNEC_RS06455	COG1846	Transcriptional regulator
PNEC_RS06475	COG0123	including yeast histone deacetylase and acetoin utilization protein
PNEC_RS06520	COG3634	alkyl hydroperoxide reductase activity
PNEC_RS06550	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
PNEC_RS06610	COG0828	Belongs to the bacterial ribosomal protein bS21 family
PNEC_RS06615	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
PNEC_RS06620	COG1469	GTP cyclohydrolase I activity
PNEC_RS06625	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
PNEC_RS06630	COG0142	geranyltranstransferase activity
PNEC_RS06635	COG1722	exodeoxyribonuclease VII activity
PNEC_RS06660	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
PNEC_RS06660	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
PNEC_RS06670	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
PNEC_RS06680	COG0210	DNA helicase
PNEC_RS06685	COG0525	valine-tRNA ligase activity
PNEC_RS06690	COG1210	Utp--glucose-1-phosphate uridylyltransferase
PNEC_RS06695	COG0425	Belongs to the sulfur carrier protein TusA family
PNEC_RS06700	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
PNEC_RS06715	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PNEC_RS06730	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
PNEC_RS06760	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
PNEC_RS06765	COG1047	Peptidyl-prolyl cis-trans
PNEC_RS06775	COG0227	Belongs to the bacterial ribosomal protein bL28 family
PNEC_RS06780	COG0267	Belongs to the bacterial ribosomal protein bL33 family
PNEC_RS06790	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
PNEC_RS06790	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
PNEC_RS06795	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
PNEC_RS06805	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
PNEC_RS06810	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
PNEC_RS06815	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
PNEC_RS06820	COG0756	dUTP diphosphatase activity
PNEC_RS06830	COG0542	response to heat
PNEC_RS06835	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
PNEC_RS06840	COG1278	Cold shock
PNEC_RS06855	COG0137	argininosuccinate synthase activity
PNEC_RS06860	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
PNEC_RS06870	COG0268	Binds directly to 16S ribosomal RNA
PNEC_RS06875	COG0728	peptidoglycan biosynthetic process
PNEC_RS06885	COG0586	Pfam SNARE associated Golgi protein
PNEC_RS06890	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
PNEC_RS06895	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
PNEC_RS06900	COG0628	permease
PNEC_RS06905	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
PNEC_RS06925	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
PNEC_RS06935	COG0443	Heat shock 70 kDa protein
PNEC_RS06940	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
PNEC_RS06945	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
PNEC_RS06950	COG1420	regulation of RNA biosynthetic process
PNEC_RS06955	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
PNEC_RS06965	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
PNEC_RS06980	COG0312	modulator of DNA gyrase
PNEC_RS06985	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
PNEC_RS06990	COG2096	Adenosyltransferase
PNEC_RS07015	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
PNEC_RS07020	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
PNEC_RS07025	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
PNEC_RS07030	COG0343	queuine tRNA-ribosyltransferase activity
PNEC_RS07035	COG1862	Preprotein translocase
PNEC_RS07040	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
PNEC_RS07045	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
PNEC_RS07060	COG0625	glutathione transferase activity
PNEC_RS07065	COG0482	sulfurtransferase activity
PNEC_RS07090	COG0459	protein refolding
PNEC_RS07095	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
PNEC_RS07140	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
PNEC_RS07145	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
PNEC_RS07150	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
PNEC_RS07160	COG0469	pyruvate kinase activity
PNEC_RS07165	COG0126	phosphoglycerate kinase activity
PNEC_RS07195	COG4783	chaperone-mediated protein folding
PNEC_RS07230	COG0861	Integral membrane protein TerC family
PNEC_RS07235	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
PNEC_RS07240	COG0045	succinate-CoA ligase (ADP-forming) activity
PNEC_RS07245	COG2137	regulation of response to DNA damage stimulus
PNEC_RS07250	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
PNEC_RS07310	COG1054	Belongs to the UPF0176 family
PNEC_RS07320	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
PNEC_RS07325	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
PNEC_RS07335	COG0815	Transfers the fatty acyl group on membrane lipoproteins
PNEC_RS07340	COG0752	glycyl-tRNA synthetase alpha subunit
PNEC_RS07345	COG0751	glycine-tRNA ligase activity
PNEC_RS07355	COG0204	Acyl-transferase
PNEC_RS07375	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PNEC_RS07380	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
PNEC_RS07395	COG0006	proline dipeptidase activity
PNEC_RS07400	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PNEC_RS07410	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
PNEC_RS07415	COG0138	bifunctional purine biosynthesis protein purh
PNEC_RS07420	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
PNEC_RS07425	COG0632	four-way junction helicase activity
PNEC_RS07430	COG2255	four-way junction helicase activity
PNEC_RS07435	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
PNEC_RS07440	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
PNEC_RS07445	COG0316	Belongs to the HesB IscA family
PNEC_RS07450	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
PNEC_RS07455	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
PNEC_RS07460	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
PNEC_RS07470	COG0418	dihydroorotase activity
PNEC_RS07480	COG5265	(ABC) transporter
PNEC_RS07485	COG0494	nUDIX hydrolase
PNEC_RS07500	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
PNEC_RS07515	COG2226	methyltransferase
PNEC_RS07530	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
PNEC_RS07545	COG0629	single-stranded DNA binding
PNEC_RS07550	COG2814	Major facilitator Superfamily
PNEC_RS07570	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
PNEC_RS07585	COG1137	ATPase activity
PNEC_RS07590	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
PNEC_RS07600	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
PNEC_RS07605	COG1660	Displays ATPase and GTPase activities
PNEC_RS07615	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
PNEC_RS07625	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
PNEC_RS07635	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
PNEC_RS07640	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
PNEC_RS07645	COG0193	aminoacyl-tRNA hydrolase activity
PNEC_RS07650	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
PNEC_RS07655	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
PNEC_RS07660	COG0742	ribosomal rna small subunit methyltransferase
PNEC_RS07665	COG0612	Peptidase, M16
PNEC_RS07670	COG0612	Peptidase, M16
PNEC_RS07680	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
PNEC_RS07685	COG1999	signal sequence binding
PNEC_RS07690	COG0109	protoheme IX farnesyltransferase activity
PNEC_RS07695	COG1612	heme a metabolic process
PNEC_RS07725	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
PNEC_RS07730	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
PNEC_RS07740	COG2226	methyltransferase
PNEC_RS07750	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
PNEC_RS07755	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
PNEC_RS07760	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
PNEC_RS07770	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
PNEC_RS07775	COG0588	phosphoglycerate mutase activity
PNEC_RS07780	COG0793	Belongs to the peptidase S41A family
PNEC_RS07790	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
PNEC_RS07795	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
PNEC_RS07845	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
PNEC_RS07850	COG0321	lipoyl(octanoyl) transferase activity
PNEC_RS07855	COG2921	Belongs to the UPF0250 family
PNEC_RS07875	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
PNEC_RS07875	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
PNEC_RS07880	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
PNEC_RS07885	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
PNEC_RS07915	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
PNEC_RS07925	COG0018	arginyl-trna synthetase
PNEC_RS07935	COG1410	methionine synthase
PNEC_RS07935	COG0646	methionine synthase
PNEC_RS07940	COG0646	methionine synthase
PNEC_RS07940	COG1410	methionine synthase
PNEC_RS07965	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
PNEC_RS08000	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
PNEC_RS08005	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
PNEC_RS08010	COG0037	tRNA processing
PNEC_RS08055	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
PNEC_RS08060	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
PNEC_RS08075	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
PNEC_RS08080	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
PNEC_RS08085	COG0708	Exodeoxyribonuclease III
PNEC_RS08100	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
PNEC_RS08110	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
PNEC_RS08120	COG0523	cobalamin synthesis protein
PNEC_RS08125	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
PNEC_RS08135	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
PNEC_RS08140	COG0154	amidase activity
PNEC_RS08145	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
PNEC_RS08150	COG1077	Cell shape determining protein MreB Mrl
PNEC_RS08165	COG0768	penicillin binding
PNEC_RS08170	COG0772	Belongs to the SEDS family
PNEC_RS08190	COG0288	reversible hydration of carbon dioxide
PNEC_RS08205	COG1187	pseudouridine synthase activity
PNEC_RS08210	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
PNEC_RS08285	COG2204	response regulator
PNEC_RS08290	COG5000	phosphorelay sensor kinase activity
PNEC_RS08300	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
PNEC_RS08300	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
PNEC_RS08305	COG0501	Belongs to the peptidase M48B family
PNEC_RS08310	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
PNEC_RS08315	COG0242	peptide deformylase activity
PNEC_RS08340	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
PNEC_RS08345	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
PNEC_RS08350	COG0706	membrane insertase activity
PNEC_RS08355	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
PNEC_RS08360	COG0594	ribonuclease P activity
PNEC_RS08365	COG0230	Belongs to the bacterial ribosomal protein bL34 family
PNEC_RS08580	COG2197	response regulator
PNEC_RS08585	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
PNEC_RS08590	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
PNEC_RS08595	COG1459	type II secretion system
PNEC_RS08600	COG1459	type II secretion system
PNEC_RS08610	COG3437	response regulator, receiver
PNEC_RS08635	COG3181	Tripartite tricarboxylate transporter family receptor
PNEC_RS08675	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
PNEC_RS08745	COG5002	protein histidine kinase activity
PNEC_RS08870	COG0697	spore germination
PNEC_RS08875	COG0697	spore germination
PNEC_RS08905	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
PNEC_RS08905	COG4106	trans-aconitate 2-methyltransferase activity
PNEC_RS08955	COG2135	peptidase activity
PNEC_RS09220	COG3046	protein related to deoxyribodipyrimidine photolyase
PNEC_RS09225	COG1403	HNH endonuclease
PNEC_RS09280	COG0625	glutathione transferase activity
PNEC_RS09320	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
PNEC_RS09320	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity