locus-tag	class	description
PNUC_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
PNUC_RS00010	COG0592	DNA-directed DNA polymerase activity
PNUC_RS00045	COG0559	Belongs to the binding-protein-dependent transport system permease family
PNUC_RS00060	COG1028	Short-chain dehydrogenase reductase Sdr
PNUC_RS00070	COG0730	response to heat
PNUC_RS00075	COG0445	tRNA wobble uridine modification
PNUC_RS00080	COG0357	Ribosomal RNA small subunit methyltransferase G
PNUC_RS00085	COG1192	Involved in chromosome partitioning
PNUC_RS00100	COG0356	it plays a direct role in the translocation of protons across the membrane
PNUC_RS00110	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
PNUC_RS00115	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
PNUC_RS00120	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
PNUC_RS00125	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
PNUC_RS00130	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
PNUC_RS00135	COG0355	proton-transporting ATP synthase activity, rotational mechanism
PNUC_RS00140	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
PNUC_RS00145	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
PNUC_RS00150	COG0509	glycine decarboxylation via glycine cleavage system
PNUC_RS00155	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PNUC_RS00170	COG3245	cytochrome
PNUC_RS00175	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
PNUC_RS00185	COG2823	Periplasmic or secreted lipoprotein
PNUC_RS00240	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
PNUC_RS00250	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
PNUC_RS00260	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
PNUC_RS00265	COG0081	regulation of translation
PNUC_RS00270	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
PNUC_RS00275	COG0222	ribosome binding
PNUC_RS00280	COG0085	RNA polymerase activity
PNUC_RS00285	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
PNUC_RS00290	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
PNUC_RS00295	COG0049	tRNA binding
PNUC_RS00300	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
PNUC_RS00305	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
PNUC_RS00310	COG0051	transcription antitermination factor activity, RNA binding
PNUC_RS00315	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
PNUC_RS00320	COG0088	Forms part of the polypeptide exit tunnel
PNUC_RS00325	COG0089	rRNA binding
PNUC_RS00330	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
PNUC_RS00335	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
PNUC_RS00340	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
PNUC_RS00345	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
PNUC_RS00350	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
PNUC_RS00355	COG0255	Belongs to the universal ribosomal protein uL29 family
PNUC_RS00360	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
PNUC_RS00365	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
PNUC_RS00370	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
PNUC_RS00375	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
PNUC_RS00380	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
PNUC_RS00385	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
PNUC_RS00390	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
PNUC_RS00395	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
PNUC_RS00400	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
PNUC_RS00405	COG1841	ribosomal large subunit assembly
PNUC_RS00410	COG0200	Binds to the 23S rRNA
PNUC_RS00415	COG0201	protein transport
PNUC_RS00420	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
PNUC_RS00425	COG0257	Belongs to the bacterial ribosomal protein bL36 family
PNUC_RS00430	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
PNUC_RS00435	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
PNUC_RS00440	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
PNUC_RS00445	COG0202	RNA polymerase activity
PNUC_RS00450	COG0203	ribosomal protein L17
PNUC_RS00460	COG4232	protein-disulfide reductase activity
PNUC_RS00475	COG0218	Necessary for normal cell division and for the maintenance of normal septation
PNUC_RS00485	COG0019	diaminopimelate decarboxylase activity
PNUC_RS00490	COG1965	Belongs to the frataxin family
PNUC_RS00495	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
PNUC_RS00525	COG0070	glutamate synthase
PNUC_RS00525	COG0069	glutamate synthase activity
PNUC_RS00525	COG0067	glutamate synthase
PNUC_RS00535	COG1127	ABC transporter
PNUC_RS00540	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
PNUC_RS00545	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
PNUC_RS00550	COG2853	Lipoprotein
PNUC_RS00565	COG1131	(ABC) transporter
PNUC_RS00570	COG0842	Transport permease protein
PNUC_RS00580	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
PNUC_RS00585	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
PNUC_RS00590	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
PNUC_RS00595	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
PNUC_RS00600	COG0131	Imidazoleglycerol-phosphate dehydratase
PNUC_RS00605	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
PNUC_RS00610	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
PNUC_RS00615	COG0107	imidazoleglycerol-phosphate synthase activity
PNUC_RS00620	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
PNUC_RS00625	COG0140	phosphoribosyl-ATP diphosphatase activity
PNUC_RS00635	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
PNUC_RS00640	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
PNUC_RS00645	COG0805	protein transport
PNUC_RS00655	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
PNUC_RS00675	COG1970	mechanosensitive ion channel activity
PNUC_RS00680	COG0723	plastoquinol--plastocyanin reductase activity
PNUC_RS00685	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
PNUC_RS00690	COG2857	Cytochrome c1
PNUC_RS00695	COG0625	glutathione transferase activity
PNUC_RS00715	COG0477	Major facilitator Superfamily
PNUC_RS00730	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
PNUC_RS00735	COG2890	protein-(glutamine-N5) methyltransferase activity
PNUC_RS00740	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
PNUC_RS00745	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
PNUC_RS00755	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
PNUC_RS00765	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
PNUC_RS00770	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PNUC_RS00775	COG0012	GTP binding
PNUC_RS00790	COG0134	indole-3-glycerol-phosphate synthase activity
PNUC_RS00795	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
PNUC_RS00800	COG0512	Glutamine amidotransferase of anthranilate synthase
PNUC_RS00810	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
PNUC_RS00815	COG2967	ApaG domain
PNUC_RS00830	COG1473	amidohydrolase
PNUC_RS00835	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
PNUC_RS00840	COG0156	8-amino-7-oxononanoate synthase activity
PNUC_RS00850	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
PNUC_RS00855	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
PNUC_RS00860	COG2001	Belongs to the MraZ family
PNUC_RS00865	COG0275	rRNA processing
PNUC_RS00880	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
PNUC_RS00885	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
PNUC_RS00890	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
PNUC_RS00895	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
PNUC_RS00900	COG0772	Belongs to the SEDS family
PNUC_RS00905	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
PNUC_RS00910	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
PNUC_RS00915	COG1181	Belongs to the D-alanine--D-alanine ligase family
PNUC_RS00920	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
PNUC_RS00935	COG0678	peroxiredoxin activity
PNUC_RS00940	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
PNUC_RS00950	COG0653	protein targeting
PNUC_RS00965	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
PNUC_RS00975	COG0494	nUDIX hydrolase
PNUC_RS00980	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
PNUC_RS00985	COG0237	dephospho-CoA kinase activity
PNUC_RS00995	COG1459	type II secretion system
PNUC_RS01005	COG4536	flavin adenine dinucleotide binding
PNUC_RS01015	COG1562	ergosterol biosynthetic process
PNUC_RS01025	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
PNUC_RS01030	COG0179	Fumarylacetoacetate (FAA) hydrolase
PNUC_RS01035	COG0142	geranyltranstransferase activity
PNUC_RS01040	COG0261	This protein binds to 23S rRNA in the presence of protein L20
PNUC_RS01045	COG0211	Belongs to the bacterial ribosomal protein bL27 family
PNUC_RS01050	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
PNUC_RS01055	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
PNUC_RS01065	COG0494	nUDIX hydrolase
PNUC_RS01070	COG0442	prolyl-tRNA aminoacylation
PNUC_RS01075	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
PNUC_RS01085	COG3023	N-Acetylmuramoyl-L-alanine amidase
PNUC_RS01095	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
PNUC_RS01115	COG2264	protein methyltransferase activity
PNUC_RS01120	COG0439	Biotin carboxylase
PNUC_RS01125	COG0511	ligase activity, forming carbon-carbon bonds
PNUC_RS01130	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
PNUC_RS01135	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PNUC_RS01140	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
PNUC_RS01145	COG1028	Short-chain dehydrogenase reductase Sdr
PNUC_RS01150	COG0557	exoribonuclease II activity
PNUC_RS01160	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
PNUC_RS01165	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
PNUC_RS01170	COG0284	orotidine-5'-phosphate decarboxylase activity
PNUC_RS01180	COG1058	Belongs to the CinA family
PNUC_RS01180	COG1546	Belongs to the CinA family
PNUC_RS01185	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
PNUC_RS01195	COG0280	phosphate acetyltransferase
PNUC_RS01195	COG0281	malic enzyme
PNUC_RS01205	COG1385	rRNA (uridine-N3-)-methyltransferase activity
PNUC_RS01210	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
PNUC_RS01215	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
PNUC_RS01220	COG0735	belongs to the Fur family
PNUC_RS01225	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
PNUC_RS01230	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
PNUC_RS01235	COG0495	leucyl-tRNA aminoacylation
PNUC_RS01250	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
PNUC_RS01255	COG1981	membrane
PNUC_RS01265	COG1773	rubredoxin
PNUC_RS01270	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
PNUC_RS01275	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
PNUC_RS01280	COG0415	Belongs to the DNA photolyase family
PNUC_RS01290	COG1678	Uncharacterized ACR, COG1678
PNUC_RS01295	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
PNUC_RS01300	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
PNUC_RS01305	COG0540	Belongs to the ATCase OTCase family
PNUC_RS01365	COG1538	Outer membrane efflux protein
PNUC_RS01370	COG1968	undecaprenyl-diphosphatase activity
PNUC_RS01385	COG0220	tRNA (guanine-N7-)-methyltransferase activity
PNUC_RS01395	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
PNUC_RS01400	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
PNUC_RS01425	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PNUC_RS01425	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PNUC_RS01435	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
PNUC_RS01450	COG0823	Involved in the tonB-independent uptake of proteins
PNUC_RS01465	COG0811	peptide transport
PNUC_RS01470	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
PNUC_RS01475	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
PNUC_RS01480	COG0563	adenylate kinase activity
PNUC_RS01485	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
PNUC_RS01490	COG2835	tetraacyldisaccharide 4'-kinase activity
PNUC_RS01495	COG1663	tetraacyldisaccharide 4'-kinase activity
PNUC_RS01500	COG0848	biopolymer transport protein
PNUC_RS01505	COG0811	peptide transport
PNUC_RS01510	COG1570	exodeoxyribonuclease VII activity
PNUC_RS01520	COG0812	UDP-N-acetylmuramate dehydrogenase activity
PNUC_RS01525	COG1666	GTP binding
PNUC_RS01535	COG4974	Belongs to the 'phage' integrase family
PNUC_RS01540	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
PNUC_RS01550	COG0302	gtp cyclohydrolase
PNUC_RS01570	COG2801	Transposase and inactivated derivatives
PNUC_RS01595	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PNUC_RS01620	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
PNUC_RS01630	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
PNUC_RS01640	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
PNUC_RS01660	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
PNUC_RS01705	COG0493	'glutamate synthase
PNUC_RS01720	COG0277	FAD linked oxidase domain protein
PNUC_RS01725	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
PNUC_RS01765	COG2755	lipolytic protein G-D-S-L family
PNUC_RS01765	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
PNUC_RS01775	COG0387	Pfam Sodium calcium exchanger
PNUC_RS01870	COG0559	Belongs to the binding-protein-dependent transport system permease family
PNUC_RS01875	COG0411	ABC transporter
PNUC_RS01910	COG0741	lytic transglycosylase activity
PNUC_RS01930	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
PNUC_RS01935	COG3040	lipid binding
PNUC_RS01940	COG2368	4-hydroxyphenylacetate
PNUC_RS01955	COG4221	oxidoreductase activity
PNUC_RS01965	COG1187	pseudouridine synthase activity
PNUC_RS01970	COG2154	pterin-4-alpha-carbinolamine dehydratase
PNUC_RS01985	COG2135	peptidase activity
PNUC_RS01990	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PNUC_RS02000	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
PNUC_RS02005	COG0492	ferredoxin-NADP+ reductase activity
PNUC_RS02010	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
PNUC_RS02015	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PNUC_RS02025	COG0303	'Molybdopterin
PNUC_RS02030	COG0746	molybdenum cofactor guanylyltransferase activity
PNUC_RS02035	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
PNUC_RS02040	COG1530	ribonuclease E activity
PNUC_RS02045	COG0564	pseudouridine synthase activity
PNUC_RS02050	COG0546	phosphoglycolate phosphatase activity
PNUC_RS02060	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
PNUC_RS02065	COG0424	maF-like protein
PNUC_RS02070	COG1399	metal-binding, possibly nucleic acid-binding protein
PNUC_RS02075	COG0333	Belongs to the bacterial ribosomal protein bL32 family
PNUC_RS02080	COG0416	fatty acid biosynthetic process
PNUC_RS02085	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
PNUC_RS02095	COG1028	Short-chain dehydrogenase reductase Sdr
PNUC_RS02100	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PNUC_RS02105	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PNUC_RS02110	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PNUC_RS02115	COG0481	GTPase activity
PNUC_RS02120	COG0681	Belongs to the peptidase S26 family
PNUC_RS02125	COG0571	ribonuclease III activity
PNUC_RS02130	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
PNUC_RS02135	COG1381	Involved in DNA repair and RecF pathway recombination
PNUC_RS02140	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
PNUC_RS02145	COG0736	holo-[acyl-carrier-protein] synthase activity
PNUC_RS02150	COG1472	Belongs to the glycosyl hydrolase 3 family
PNUC_RS02160	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
PNUC_RS02170	COG0322	excinuclease ABC activity
PNUC_RS02195	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
PNUC_RS02200	COG0252	asparaginase activity
PNUC_RS02205	COG0360	Binds together with S18 to 16S ribosomal RNA
PNUC_RS02215	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
PNUC_RS02220	COG0359	binds to the 23S rRNA
PNUC_RS02235	COG0668	transmembrane transport
PNUC_RS02240	COG0791	NLP P60 protein
PNUC_RS02245	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
PNUC_RS02255	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
PNUC_RS02260	COG0726	polysaccharide deacetylase
PNUC_RS02270	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PNUC_RS02270	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
PNUC_RS02280	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
PNUC_RS02285	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
PNUC_RS02295	COG0436	Aminotransferase
PNUC_RS02310	COG0303	'Molybdopterin
PNUC_RS02320	COG0314	molybdopterin synthase activity
PNUC_RS02325	COG2272	Belongs to the type-B carboxylesterase lipase family
PNUC_RS02340	COG2827	Endonuclease containing a URI domain
PNUC_RS02345	COG0542	response to heat
PNUC_RS02365	COG2217	Heavy metal translocating P-type atpase
PNUC_RS02375	COG3278	Belongs to the heme-copper respiratory oxidase family
PNUC_RS02395	COG0348	domain, Protein
PNUC_RS02410	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PNUC_RS02430	COG0739	heme binding
PNUC_RS02435	COG1250	3-hydroxyacyl-CoA dehydrogenase
PNUC_RS02440	COG4948	Mandelate Racemase Muconate Lactonizing
PNUC_RS02450	COG2358	TRAP transporter, solute receptor (TAXI family
PNUC_RS02455	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PNUC_RS02460	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PNUC_RS02465	COG1250	3-hydroxyacyl-CoA dehydrogenase
PNUC_RS02480	COG3909	cytochrome
PNUC_RS02485	COG1994	Peptidase M50
PNUC_RS02490	COG3384	dioxygenase
PNUC_RS02495	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
PNUC_RS02515	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PNUC_RS02530	COG1054	Belongs to the UPF0176 family
PNUC_RS02535	COG3181	Tripartite tricarboxylate transporter family receptor
PNUC_RS02550	COG2264	protein methyltransferase activity
PNUC_RS02565	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
PNUC_RS02580	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
PNUC_RS02590	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
PNUC_RS02595	COG0287	Prephenate dehydrogenase
PNUC_RS02600	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
PNUC_RS02605	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
PNUC_RS02615	COG0776	regulation of translation
PNUC_RS02620	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
PNUC_RS02630	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
PNUC_RS02635	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PNUC_RS02655	COG2951	lytic endotransglycosylase activity
PNUC_RS02660	COG0123	including yeast histone deacetylase and acetoin utilization protein
PNUC_RS02665	COG0318	PFAM AMP-dependent synthetase and ligase
PNUC_RS02680	COG1960	acyl-CoA dehydrogenase activity
PNUC_RS02695	COG0228	four-way junction DNA binding
PNUC_RS02700	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
PNUC_RS02705	COG0336	Belongs to the RNA methyltransferase TrmD family
PNUC_RS02710	COG0335	large ribosomal subunit rRNA binding
PNUC_RS02720	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
PNUC_RS02725	COG1162	GTPase activity
PNUC_RS02730	COG0501	Belongs to the peptidase M48B family
PNUC_RS02735	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
PNUC_RS02740	COG0521	Mo-molybdopterin cofactor biosynthetic process
PNUC_RS02745	COG0312	modulator of DNA gyrase
PNUC_RS02750	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
PNUC_RS02785	COG3162	membrane
PNUC_RS02810	COG2301	Belongs to the HpcH HpaI aldolase family
PNUC_RS02815	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
PNUC_RS02815	COG1042	CoA-binding domain protein
PNUC_RS02815	COG0045	succinate-CoA ligase (ADP-forming) activity
PNUC_RS02830	COG2365	Tyrosine phosphatase family
PNUC_RS02875	COG0038	chloride channel
PNUC_RS02880	COG0028	Belongs to the TPP enzyme family
PNUC_RS02890	COG1529	Aldehyde oxidase and xanthine dehydrogenase
PNUC_RS02890	COG2010	Cytochrome c
PNUC_RS02945	COG0784	Response regulator, receiver
PNUC_RS02945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PNUC_RS02945	COG2205	protein histidine kinase activity
PNUC_RS02945	COG2198	Histidine kinase
PNUC_RS02980	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
PNUC_RS03005	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
PNUC_RS03045	COG1595	DNA-templated transcription, initiation
PNUC_RS03055	COG1278	Cold shock
PNUC_RS03060	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
PNUC_RS03090	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PNUC_RS03100	COG2084	Dehydrogenase
PNUC_RS03110	COG0860	N-Acetylmuramoyl-L-alanine amidase
PNUC_RS03115	COG0802	atpase or kinase
PNUC_RS03120	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
PNUC_RS03135	COG0277	FAD linked oxidase domain protein
PNUC_RS03135	COG0247	lactate metabolic process
PNUC_RS03145	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
PNUC_RS03150	COG3193	protein, possibly involved in utilization of glycolate and propanediol
PNUC_RS03155	COG0513	Belongs to the DEAD box helicase family
PNUC_RS03160	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PNUC_RS03170	COG0859	PFAM glycosyl transferase family 9
PNUC_RS03175	COG1215	transferase activity, transferring glycosyl groups
PNUC_RS03180	COG0463	Glycosyl transferase, family 2
PNUC_RS03185	COG1132	(ABC) transporter
PNUC_RS03190	COG1530	ribonuclease E activity
PNUC_RS03200	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
PNUC_RS03205	COG0799	negative regulation of ribosome biogenesis
PNUC_RS03210	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
PNUC_RS03215	COG0408	coproporphyrinogen oxidase activity
PNUC_RS03220	COG0151	Belongs to the GarS family
PNUC_RS03225	COG0217	transcriptional regulatory protein
PNUC_RS03240	COG0583	DNA-binding transcription factor activity
PNUC_RS03255	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
PNUC_RS03265	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
PNUC_RS03280	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
PNUC_RS03295	COG0318	PFAM AMP-dependent synthetase and ligase
PNUC_RS03300	COG0730	response to heat
PNUC_RS03315	COG4771	TonB-dependent receptor
PNUC_RS03335	COG4191	Histidine kinase
PNUC_RS03340	COG1804	L-carnitine dehydratase bile acid-inducible protein F
PNUC_RS03345	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
PNUC_RS03355	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
PNUC_RS03360	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
PNUC_RS03375	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PNUC_RS03375	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PNUC_RS03380	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
PNUC_RS03385	COG0717	Belongs to the dCTP deaminase family
PNUC_RS03400	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
PNUC_RS03415	COG0165	Argininosuccinate lyase
PNUC_RS03420	COG0181	hydroxymethylbilane synthase activity
PNUC_RS03430	COG3161	chorismate lyase activity
PNUC_RS03435	COG0513	Belongs to the DEAD box helicase family
PNUC_RS03450	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
PNUC_RS03455	COG0259	pyridoxamine-phosphate oxidase activity
PNUC_RS03460	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
PNUC_RS03465	COG1113	amino acid transport
PNUC_RS03470	COG0686	Belongs to the AlaDH PNT family
PNUC_RS03475	COG2119	membrane
PNUC_RS03480	COG0308	aminopeptidase N
PNUC_RS03485	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
PNUC_RS03495	COG0189	ligase activity
PNUC_RS03495	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
PNUC_RS03500	COG1132	(ABC) transporter
PNUC_RS03530	COG4772	TonB-dependent receptor
PNUC_RS03550	COG0129	dihydroxy-acid dehydratase activity
PNUC_RS03575	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
PNUC_RS03590	COG1487	ribonuclease activity
PNUC_RS03595	COG0492	ferredoxin-NADP+ reductase activity
PNUC_RS03600	COG1674	ftsk spoiiie
PNUC_RS03605	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
PNUC_RS03610	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
PNUC_RS03630	COG0514	ATP-dependent DNA helicase (RecQ)
PNUC_RS03650	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
PNUC_RS03660	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
PNUC_RS03665	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
PNUC_RS03670	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
PNUC_RS03680	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
PNUC_RS03690	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
PNUC_RS03705	COG2841	Protein conserved in bacteria
PNUC_RS03710	COG2824	Alkylphosphonate utilization operon protein PhnA
PNUC_RS03720	COG1950	PFAM Membrane protein of
PNUC_RS03725	COG2900	Belongs to the SlyX family
PNUC_RS03735	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PNUC_RS03745	COG4681	YaeQ
PNUC_RS03750	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
PNUC_RS03755	COG0635	Involved in the biosynthesis of porphyrin-containing compound
PNUC_RS03760	COG3047	cAMP biosynthetic process
PNUC_RS03770	COG0488	(ABC) transporter
PNUC_RS03785	COG2721	sulfolactate sulfo-lyase activity
PNUC_RS03790	COG1741	Belongs to the pirin family
PNUC_RS03805	COG0446	pyridine nucleotide-disulphide oxidoreductase
PNUC_RS03815	COG0339	signal peptide processing
PNUC_RS03820	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
PNUC_RS03825	COG4566	intracellular signal transduction
PNUC_RS03835	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
PNUC_RS03840	COG0508	dehydrogenase complex catalyzes the overall conversion of
PNUC_RS03845	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PNUC_RS03870	COG0167	dihydroorotate dehydrogenase activity
PNUC_RS03875	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
PNUC_RS03880	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
PNUC_RS03905	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
PNUC_RS03915	COG1250	3-hydroxyacyl-CoA dehydrogenase
PNUC_RS03920	COG0625	glutathione transferase activity
PNUC_RS03925	COG0436	Aminotransferase
PNUC_RS03930	COG3022	response to hydroperoxide
PNUC_RS03945	COG0039	L-malate dehydrogenase activity
PNUC_RS03950	COG2188	Transcriptional regulator
PNUC_RS03960	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
PNUC_RS03965	COG1053	succinate dehydrogenase
PNUC_RS03970	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
PNUC_RS03975	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
PNUC_RS03980	COG0372	Belongs to the citrate synthase family
PNUC_RS03985	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
PNUC_RS03995	COG0066	3-isopropylmalate dehydratase activity
PNUC_RS04000	COG0473	3-isopropylmalate dehydrogenase activity
PNUC_RS04015	COG0101	tRNA pseudouridine synthase activity
PNUC_RS04020	COG0135	phosphoribosylanthranilate isomerase activity
PNUC_RS04025	COG0133	tryptophan synthase activity
PNUC_RS04030	COG0159	tryptophan synthase activity
PNUC_RS04035	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
PNUC_RS04040	COG0285	dihydrofolate synthase activity
PNUC_RS04095	COG3258	Cytochrome c
PNUC_RS04100	COG2863	cytochrome
PNUC_RS04105	COG2391	methyltransferase activity
PNUC_RS04130	COG0640	Transcriptional regulator
PNUC_RS04140	COG1575	Belongs to the MenA family. Type 1 subfamily
PNUC_RS04155	COG0730	response to heat
PNUC_RS04170	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
PNUC_RS04235	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PNUC_RS04235	COG3453	Protein conserved in bacteria
PNUC_RS04245	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
PNUC_RS04255	COG1960	acyl-CoA dehydrogenase activity
PNUC_RS04265	COG0488	(ABC) transporter
PNUC_RS04280	COG0346	lactoylglutathione lyase activity
PNUC_RS04305	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
PNUC_RS04315	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
PNUC_RS04320	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
PNUC_RS04325	COG0291	Belongs to the bacterial ribosomal protein bL35 family
PNUC_RS04330	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
PNUC_RS04335	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
PNUC_RS04340	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PNUC_RS04340	COG0072	phenylalanine-tRNA ligase activity
PNUC_RS04345	COG0776	regulation of translation
PNUC_RS04350	COG0789	Transcriptional regulator
PNUC_RS04365	COG2916	Histone family protein nucleoid-structuring protein H-NS
PNUC_RS04375	COG0567	Dehydrogenase, E1 component
PNUC_RS04380	COG0508	dehydrogenase complex catalyzes the overall conversion of
PNUC_RS04385	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PNUC_RS04390	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
PNUC_RS04395	COG0613	PHP domain protein
PNUC_RS04400	COG0180	Tryptophanyl-tRNA synthetase
PNUC_RS04410	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PNUC_RS04415	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
PNUC_RS04420	COG2850	peptidyl-arginine hydroxylation
PNUC_RS04425	COG1047	Peptidyl-prolyl cis-trans
PNUC_RS04430	COG1045	serine acetyltransferase
PNUC_RS04440	COG0483	inositol monophosphate 1-phosphatase activity
PNUC_RS04445	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PNUC_RS04460	COG0215	cysteine-tRNA ligase activity
PNUC_RS04470	COG0825	malonyl-CoA metabolic process
PNUC_RS04475	COG0037	tRNA processing
PNUC_RS04480	COG0527	aspartate kinase activity
PNUC_RS04535	COG1804	L-carnitine dehydratase bile acid-inducible protein F
PNUC_RS04540	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
PNUC_RS04585	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
PNUC_RS04595	COG0318	PFAM AMP-dependent synthetase and ligase
PNUC_RS04600	COG0129	dihydroxy-acid dehydratase activity
PNUC_RS04615	COG0826	peptidase U32
PNUC_RS04630	COG0352	thiamine-phosphate diphosphorylase activity
PNUC_RS04630	COG0351	phosphomethylpyrimidine kinase
PNUC_RS04650	COG2022	thiamine diphosphate biosynthetic process
PNUC_RS04665	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
PNUC_RS04670	COG1051	belongs to the nudix hydrolase family
PNUC_RS04685	COG1804	L-carnitine dehydratase bile acid-inducible protein F
PNUC_RS04700	COG3608	succinylglutamate desuccinylase aspartoacylase
PNUC_RS04700	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
PNUC_RS04705	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
PNUC_RS04720	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PNUC_RS04735	COG1802	Transcriptional regulator
PNUC_RS04740	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
PNUC_RS04740	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
PNUC_RS04745	COG1703	isobutyryl-CoA mutase activity
PNUC_RS04750	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
PNUC_RS04755	COG4770	biotin carboxylase activity
PNUC_RS04765	COG1214	PFAM Peptidase M22, glycoprotease
PNUC_RS04770	COG0456	acetyltransferase
PNUC_RS04795	COG0564	pseudouridine synthase activity
PNUC_RS04800	COG1496	oxidoreductase activity
PNUC_RS04805	COG3243	poly(R)-hydroxyalkanoic acid synthase
PNUC_RS04810	COG1028	Short-chain dehydrogenase reductase Sdr
PNUC_RS04820	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
PNUC_RS04825	COG0183	Belongs to the thiolase family
PNUC_RS04830	COG0560	Phosphoserine phosphatase
PNUC_RS04835	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
PNUC_RS04840	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
PNUC_RS04845	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
PNUC_RS04850	COG0778	Nitroreductase
PNUC_RS04860	COG0544	peptidyl-prolyl cis-trans isomerase activity
PNUC_RS04865	COG0740	serine-type endopeptidase activity
PNUC_RS04870	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
PNUC_RS04875	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
PNUC_RS04895	COG4181	ATPase activity
PNUC_RS04900	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
PNUC_RS04900	COG0047	phosphoribosylformylglycinamidine synthase activity
PNUC_RS04925	COG0504	CTP synthase activity
PNUC_RS04930	COG2877	3-deoxy-8-phosphooctulonate synthase activity
PNUC_RS04935	COG0148	phosphopyruvate hydratase activity
PNUC_RS04940	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
PNUC_RS04945	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
PNUC_RS04950	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PNUC_RS04990	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PNUC_RS05005	COG2084	Dehydrogenase
PNUC_RS05030	COG0666	response to abiotic stimulus
PNUC_RS05035	COG0084	hydrolase, TatD family'
PNUC_RS05040	COG0470	DNA polymerase III
PNUC_RS05045	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
PNUC_RS05050	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
PNUC_RS05055	COG0354	folic acid binding
PNUC_RS05070	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
PNUC_RS05075	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
PNUC_RS05080	COG2917	probably involved in intracellular septation
PNUC_RS05090	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PNUC_RS05100	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
PNUC_RS05110	COG1295	ribonuclease BN
PNUC_RS05125	COG0277	FAD linked oxidase domain protein
PNUC_RS05135	COG0596	Alpha beta hydrolase
PNUC_RS05155	COG1126	abc transporter atp-binding protein
PNUC_RS05160	COG0765	amino acid transport
PNUC_RS05165	COG0765	amino acid transport
PNUC_RS05170	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PNUC_RS05175	COG1252	NADH dehydrogenase
PNUC_RS05180	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
PNUC_RS05185	COG4191	Histidine kinase
PNUC_RS05190	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
PNUC_RS05195	COG1116	anion transmembrane transporter activity
PNUC_RS05200	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PNUC_RS05205	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PNUC_RS05205	COG1116	anion transmembrane transporter activity
PNUC_RS05215	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PNUC_RS05220	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PNUC_RS05230	COG0243	molybdopterin cofactor binding
PNUC_RS05235	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
PNUC_RS05285	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PNUC_RS05295	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PNUC_RS05300	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
PNUC_RS05315	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
PNUC_RS05320	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
PNUC_RS05325	COG0505	Belongs to the CarA family
PNUC_RS05330	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PNUC_RS05335	COG1388	LysM domain
PNUC_RS05335	COG0741	lytic transglycosylase activity
PNUC_RS05340	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PNUC_RS05345	COG2226	methyltransferase
PNUC_RS05350	COG0328	RNA-DNA hybrid ribonuclease activity
PNUC_RS05355	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PNUC_RS05365	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
PNUC_RS05370	COG0473	3-isopropylmalate dehydrogenase activity
PNUC_RS05390	COG0154	amidase activity
PNUC_RS05395	COG3181	Tripartite tricarboxylate transporter family receptor
PNUC_RS05400	COG1902	pentaerythritol trinitrate reductase activity
PNUC_RS05415	COG0494	nUDIX hydrolase
PNUC_RS05420	COG1007	ATP synthesis coupled electron transport
PNUC_RS05435	COG0713	ATP synthesis coupled electron transport
PNUC_RS05445	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PNUC_RS05450	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
PNUC_RS05455	COG1034	ATP synthesis coupled electron transport
PNUC_RS05470	COG0649	NAD binding
PNUC_RS05475	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PNUC_RS05480	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PNUC_RS05485	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PNUC_RS05495	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
PNUC_RS05500	COG0149	triose-phosphate isomerase activity
PNUC_RS05510	COG1185	polyribonucleotide nucleotidyltransferase activity
PNUC_RS05515	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
PNUC_RS05525	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
PNUC_RS05530	COG1183	phosphatidylcholine synthase activity
PNUC_RS05535	COG0688	phosphatidylethanolamine metabolic process
PNUC_RS05540	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
PNUC_RS05545	COG0440	acetolactate synthase activity
PNUC_RS05550	COG0028	Belongs to the TPP enzyme family
PNUC_RS05575	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
PNUC_RS05580	COG1028	Short-chain dehydrogenase reductase Sdr
PNUC_RS05595	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
PNUC_RS05595	COG3008	intermembrane lipid transfer
PNUC_RS05600	COG1127	ABC transporter
PNUC_RS05605	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
PNUC_RS05620	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
PNUC_RS05625	COG1758	RNA polymerase activity
PNUC_RS05630	COG0194	GDP metabolic process
PNUC_RS05635	COG1561	YicC-like family, N-terminal region
PNUC_RS05640	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
PNUC_RS05645	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
PNUC_RS05650	COG0635	Involved in the biosynthesis of porphyrin-containing compound
PNUC_RS05660	COG2015	COG2015, Alkyl sulfatase and related hydrolases
PNUC_RS05665	COG4191	Histidine kinase
PNUC_RS05665	COG2205	protein histidine kinase activity
PNUC_RS05665	COG0745	RESPONSE REGULATOR receiver
PNUC_RS05700	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
PNUC_RS05705	COG0166	Belongs to the GPI family
PNUC_RS05720	COG2831	hemolysin activation secretion protein
PNUC_RS05730	COG0457	Tetratricopeptide repeat
PNUC_RS05745	COG0529	Catalyzes the synthesis of activated sulfate
PNUC_RS05765	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
PNUC_RS05780	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
PNUC_RS05790	COG2337	Toxic component of a toxin-antitoxin (TA) module
PNUC_RS05795	COG2336	PFAM SpoVT AbrB
PNUC_RS05800	COG3383	formate dehydrogenase (NAD+) activity
PNUC_RS05945	COG0732	type I restriction modification DNA specificity domain
PNUC_RS05985	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PNUC_RS05995	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
PNUC_RS06030	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
PNUC_RS06070	COG3258	Cytochrome c
PNUC_RS06100	COG1380	Effector of murein hydrolase LrgA
PNUC_RS06105	COG1346	cytolysis
PNUC_RS06120	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
PNUC_RS06135	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
PNUC_RS06140	COG2194	sulfuric ester hydrolase activity
PNUC_RS06150	COG0457	Tetratricopeptide repeat
PNUC_RS06155	COG1215	transferase activity, transferring glycosyl groups
PNUC_RS06175	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
PNUC_RS06190	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
PNUC_RS06195	COG0730	response to heat
PNUC_RS06200	COG0154	amidase activity
PNUC_RS06210	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PNUC_RS06215	COG1116	anion transmembrane transporter activity
PNUC_RS06225	COG0154	amidase activity
PNUC_RS06235	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PNUC_RS06240	COG1116	anion transmembrane transporter activity
PNUC_RS06255	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
PNUC_RS06260	COG0830	nickel cation binding
PNUC_RS06265	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
PNUC_RS06270	COG0804	urea catabolic process
PNUC_RS06285	COG0831	urea catabolic process
PNUC_RS06290	COG0829	nickel cation binding
PNUC_RS06355	COG0069	glutamate synthase activity
PNUC_RS06360	COG2203	Gaf domain
PNUC_RS06360	COG2199	diguanylate cyclase activity
PNUC_RS06370	COG0564	pseudouridine synthase activity
PNUC_RS06405	COG2307	Protein conserved in bacteria
PNUC_RS06405	COG2308	Evidence 4 Homologs of previously reported genes of
PNUC_RS06420	COG2183	response to ionizing radiation
PNUC_RS06425	COG2814	Major facilitator Superfamily
PNUC_RS06430	COG1217	gtp-binding protein TYPA
PNUC_RS06435	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
PNUC_RS06440	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
PNUC_RS06445	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
PNUC_RS06450	COG2251	uridine kinase activity
PNUC_RS06450	COG0195	Participates in both transcription termination and antitermination
PNUC_RS06455	COG0779	Required for maturation of 30S ribosomal subunits
PNUC_RS06460	COG1187	pseudouridine synthase activity
PNUC_RS06465	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
PNUC_RS06470	COG1752	Esterase of the alpha-beta hydrolase superfamily
PNUC_RS06475	COG0791	NLP P60 protein
PNUC_RS06480	COG4172	Belongs to the ABC transporter superfamily
PNUC_RS06485	COG4239	(ABC) transporter, permease
PNUC_RS06490	COG4174	ABC transporter (Permease)
PNUC_RS06495	COG4166	transmembrane transport
PNUC_RS06515	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
PNUC_RS06525	COG2301	Belongs to the HpcH HpaI aldolase family
PNUC_RS06555	COG2826	transposase and inactivated derivatives, IS30 family
PNUC_RS06575	COG2204	response regulator
PNUC_RS06580	COG3852	Histidine kinase
PNUC_RS06585	COG0174	glutamine synthetase
PNUC_RS06615	COG1643	Atp-dependent helicase
PNUC_RS06620	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
PNUC_RS06620	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
PNUC_RS06625	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
PNUC_RS06630	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
PNUC_RS06635	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
PNUC_RS06650	COG2610	gluconate transmembrane transporter activity
PNUC_RS06660	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PNUC_RS06665	COG0557	exoribonuclease II activity
PNUC_RS06675	COG0531	amino acid
PNUC_RS06715	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
PNUC_RS06720	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
PNUC_RS06725	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
PNUC_RS06730	COG0330	HflC and HflK could
PNUC_RS06735	COG0330	HflC and HflK could
PNUC_RS06740	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
PNUC_RS06745	COG1923	regulation of RNA biosynthetic process
PNUC_RS06750	COG1160	GTP binding
PNUC_RS06765	COG0124	histidyl-tRNA synthetase
PNUC_RS06770	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
PNUC_RS06775	COG0820	rRNA (adenine-C2-)-methyltransferase activity
PNUC_RS06780	COG0105	UTP biosynthetic process
PNUC_RS06790	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
PNUC_RS06805	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
PNUC_RS06810	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
PNUC_RS06845	COG1074	ATP-dependent DNA helicase activity
PNUC_RS06860	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
PNUC_RS06865	COG0254	rRNA binding
PNUC_RS06875	COG0534	Mate efflux family protein
PNUC_RS06905	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
PNUC_RS06915	COG1024	Enoyl-CoA hydratase
PNUC_RS06920	COG0741	lytic transglycosylase activity
PNUC_RS06925	COG1073	alpha beta
PNUC_RS06960	COG0235	Class ii aldolase
PNUC_RS06995	COG2223	nitrite transmembrane transporter activity
PNUC_RS07000	COG1910	domain protein
PNUC_RS07010	COG3585	molybdate ion transport
PNUC_RS07035	COG0513	Belongs to the DEAD box helicase family
PNUC_RS07040	COG1305	Transglutaminase-like
PNUC_RS07045	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PNUC_RS07070	COG3181	Tripartite tricarboxylate transporter family receptor
PNUC_RS07080	COG0179	Fumarylacetoacetate (FAA) hydrolase
PNUC_RS07105	COG0861	Integral membrane protein TerC family
PNUC_RS07110	COG2081	HI0933 family
PNUC_RS07120	COG1611	Belongs to the LOG family
PNUC_RS07135	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
PNUC_RS07140	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
PNUC_RS07140	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
PNUC_RS07145	COG0697	spore germination
PNUC_RS07160	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
PNUC_RS07195	COG3038	cytochrome b561
PNUC_RS07200	COG1902	pentaerythritol trinitrate reductase activity
PNUC_RS07205	COG0583	DNA-binding transcription factor activity
PNUC_RS07210	COG1592	Rubrerythrin
PNUC_RS07215	COG1773	rubredoxin
PNUC_RS07220	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PNUC_RS07240	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
PNUC_RS07240	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
PNUC_RS07255	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
PNUC_RS07260	COG1028	Short-chain dehydrogenase reductase Sdr
PNUC_RS07265	COG1238	metal cluster binding
PNUC_RS07270	COG1960	acyl-CoA dehydrogenase activity
PNUC_RS07285	COG3568	Endonuclease Exonuclease Phosphatase
PNUC_RS07290	COG4662	Binding-protein-dependent transport system inner membrane component
PNUC_RS07295	COG1131	(ABC) transporter
PNUC_RS07315	COG0437	4 iron, 4 sulfur cluster binding
PNUC_RS07350	COG0489	protein tyrosine kinase activity
PNUC_RS07355	COG0306	phosphate transporter
PNUC_RS07360	COG1392	Phosphate transport regulator
PNUC_RS07370	COG2217	Heavy metal translocating P-type atpase
PNUC_RS07400	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
PNUC_RS07410	COG1619	proteins homologs of microcin C7 resistance protein MccF
PNUC_RS07425	COG0602	queuosine metabolic process
PNUC_RS07440	COG2833	Protein of unknown function (DUF455)
PNUC_RS07445	COG0518	GMP synthase (glutamine-hydrolyzing) activity
PNUC_RS07445	COG0519	Catalyzes the synthesis of GMP from XMP
PNUC_RS07460	COG2867	negative regulation of translational initiation
PNUC_RS07465	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
PNUC_RS07470	COG2308	Evidence 4 Homologs of previously reported genes of
PNUC_RS07495	COG2801	Transposase and inactivated derivatives
PNUC_RS07505	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
PNUC_RS07515	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PNUC_RS07520	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
PNUC_RS07525	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PNUC_RS07530	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PNUC_RS07535	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
PNUC_RS07540	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PNUC_RS07555	COG0750	zinc metalloprotease
PNUC_RS07560	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
PNUC_RS07565	COG0575	Belongs to the CDS family
PNUC_RS07570	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
PNUC_RS07575	COG0233	cytoplasmic translational termination
PNUC_RS07580	COG0528	UMP kinase activity
PNUC_RS07585	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
PNUC_RS07590	COG0052	Belongs to the universal ribosomal protein uS2 family
PNUC_RS07595	COG0024	Methionine aminopeptidase
PNUC_RS07600	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
PNUC_RS07605	COG2259	Doxx family
PNUC_RS07610	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
PNUC_RS07625	COG2171	N-acyltransferase activity
PNUC_RS07630	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
PNUC_RS07635	COG2890	protein-(glutamine-N5) methyltransferase activity
PNUC_RS07650	COG3158	transport of potassium into the cell
PNUC_RS07670	COG0084	hydrolase, TatD family'
PNUC_RS07675	COG1136	(ABC) transporter
PNUC_RS07690	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
PNUC_RS07695	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
PNUC_RS07700	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
PNUC_RS07720	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
PNUC_RS07725	COG0242	peptide deformylase activity
PNUC_RS07730	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
PNUC_RS07740	COG0730	response to heat
PNUC_RS07745	COG0175	sulfate reduction
PNUC_RS07750	COG0175	sulfate reduction
PNUC_RS07755	COG2895	sulfate adenylyltransferase (ATP) activity
PNUC_RS07760	COG3064	Membrane
PNUC_RS07785	COG0443	Heat shock 70 kDa protein
PNUC_RS07790	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
PNUC_RS07800	COG0822	iron-sulfur transferase activity
PNUC_RS07805	COG1104	cysteine desulfurase activity
PNUC_RS07815	COG0556	nucleotide-excision repair
PNUC_RS07830	COG2878	Part of a membrane complex involved in electron transport
PNUC_RS07835	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
PNUC_RS07855	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
PNUC_RS07875	COG2814	Major facilitator Superfamily
PNUC_RS07880	COG3181	Tripartite tricarboxylate transporter family receptor
PNUC_RS07890	COG4235	cytochrome complex assembly
PNUC_RS07895	COG3088	subunit of a heme lyase
PNUC_RS07900	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PNUC_RS07910	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
PNUC_RS07925	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
PNUC_RS07930	COG4133	protoheme IX ABC transporter activity
PNUC_RS07945	COG3038	cytochrome b561
PNUC_RS07960	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
PNUC_RS07985	COG0123	including yeast histone deacetylase and acetoin utilization protein
PNUC_RS08015	COG3634	alkyl hydroperoxide reductase activity
PNUC_RS08035	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
PNUC_RS08045	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
PNUC_RS08050	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
PNUC_RS08060	COG2186	Transcriptional regulator
PNUC_RS08070	COG0583	DNA-binding transcription factor activity
PNUC_RS08080	COG0596	Alpha beta hydrolase
PNUC_RS08100	COG0508	dehydrogenase complex catalyzes the overall conversion of
PNUC_RS08105	COG1522	sequence-specific DNA binding
PNUC_RS08110	COG1028	Short-chain dehydrogenase reductase Sdr
PNUC_RS08115	COG1960	acyl-CoA dehydrogenase activity
PNUC_RS08120	COG1024	Enoyl-CoA hydratase
PNUC_RS08130	COG1024	Enoyl-CoA hydratase
PNUC_RS08140	COG0583	DNA-binding transcription factor activity
PNUC_RS08145	COG0477	Major facilitator Superfamily
PNUC_RS08145	COG0477	Major facilitator Superfamily
PNUC_RS08150	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PNUC_RS08160	COG4659	FMN binding
PNUC_RS08175	COG3622	Belongs to the hyi family
PNUC_RS08190	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
PNUC_RS08190	COG3008	intermembrane lipid transfer
PNUC_RS08195	COG2995	paraquat-inducible protein a
PNUC_RS08200	COG2995	paraquat-inducible protein a
PNUC_RS08230	COG0798	PFAM Bile acid sodium symporter
PNUC_RS08250	COG2326	polyphosphate kinase activity
PNUC_RS08270	COG0438	transferase activity, transferring glycosyl groups
PNUC_RS08275	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
PNUC_RS08285	COG0248	Ppx GppA phosphatase
PNUC_RS08310	COG1285	pathogenesis
PNUC_RS08320	COG5002	protein histidine kinase activity
PNUC_RS08325	COG0745	RESPONSE REGULATOR receiver
PNUC_RS08335	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
PNUC_RS08340	COG0581	inorganic phosphate transmembrane transporter activity
PNUC_RS08345	COG0573	inorganic phosphate transmembrane transporter activity
PNUC_RS08350	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
PNUC_RS08375	COG3046	protein related to deoxyribodipyrimidine photolyase
PNUC_RS08385	COG1403	HNH endonuclease
PNUC_RS08390	COG1024	Enoyl-CoA hydratase
PNUC_RS08395	COG1804	L-carnitine dehydratase bile acid-inducible protein F
PNUC_RS08405	COG1294	oxidase, subunit
PNUC_RS08410	COG1271	oxidase subunit
PNUC_RS08415	COG0579	oxidoreductase
PNUC_RS08425	COG0114	fumarate hydratase activity
PNUC_RS08465	COG2032	superoxide dismutase activity
PNUC_RS08490	COG3622	Belongs to the hyi family
PNUC_RS08495	COG0235	Class ii aldolase
PNUC_RS08500	COG3395	kinase activity
PNUC_RS08505	COG2084	Dehydrogenase
PNUC_RS08510	COG2271	Major facilitator Superfamily
PNUC_RS08520	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PNUC_RS08525	COG0697	spore germination
PNUC_RS08545	COG1454	alcohol dehydrogenase
PNUC_RS08560	COG0778	Nitroreductase
PNUC_RS08565	COG0322	excinuclease ABC activity
PNUC_RS08595	COG3788	relative of glutathione S-transferase, MAPEG superfamily
PNUC_RS08605	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
PNUC_RS08605	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PNUC_RS08620	COG1131	(ABC) transporter
PNUC_RS08625	COG0842	Transport permease protein
PNUC_RS08640	COG1262	PFAM Formylglycine-generating sulfatase enzyme
PNUC_RS08645	COG0436	Aminotransferase
PNUC_RS08655	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
PNUC_RS08660	COG0477	Major facilitator Superfamily
PNUC_RS08665	COG0745	RESPONSE REGULATOR receiver
PNUC_RS08670	COG2205	protein histidine kinase activity
PNUC_RS08675	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
PNUC_RS08680	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
PNUC_RS08685	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
PNUC_RS08730	COG0789	Transcriptional regulator
PNUC_RS08850	COG0828	Belongs to the bacterial ribosomal protein bS21 family
PNUC_RS08855	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
PNUC_RS08860	COG1469	GTP cyclohydrolase I activity
PNUC_RS08865	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
PNUC_RS08870	COG0142	geranyltranstransferase activity
PNUC_RS08875	COG1722	exodeoxyribonuclease VII activity
PNUC_RS08900	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
PNUC_RS08900	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
PNUC_RS08910	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
PNUC_RS08920	COG0210	DNA helicase
PNUC_RS08925	COG0525	valine-tRNA ligase activity
PNUC_RS08930	COG1210	Utp--glucose-1-phosphate uridylyltransferase
PNUC_RS08935	COG0425	Belongs to the sulfur carrier protein TusA family
PNUC_RS08940	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
PNUC_RS08955	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PNUC_RS08970	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
PNUC_RS08980	COG0411	ABC transporter
PNUC_RS09000	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
PNUC_RS09005	COG1047	Peptidyl-prolyl cis-trans
PNUC_RS09010	COG2003	Belongs to the UPF0758 family
PNUC_RS09015	COG0227	Belongs to the bacterial ribosomal protein bL28 family
PNUC_RS09020	COG0267	Belongs to the bacterial ribosomal protein bL33 family
PNUC_RS09030	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
PNUC_RS09030	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
PNUC_RS09035	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
PNUC_RS09040	COG0196	riboflavin kinase activity
PNUC_RS09045	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
PNUC_RS09050	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
PNUC_RS09055	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
PNUC_RS09060	COG0756	dUTP diphosphatase activity
PNUC_RS09065	COG0590	tRNA wobble adenosine to inosine editing
PNUC_RS09070	COG1301	dicarboxylic acid transport
PNUC_RS09085	COG0542	response to heat
PNUC_RS09090	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
PNUC_RS09095	COG1278	Cold shock
PNUC_RS09105	COG3123	guanosine phosphorylase activity
PNUC_RS09110	COG0137	argininosuccinate synthase activity
PNUC_RS09115	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
PNUC_RS09125	COG0268	Binds directly to 16S ribosomal RNA
PNUC_RS09130	COG0728	peptidoglycan biosynthetic process
PNUC_RS09140	COG0586	Pfam SNARE associated Golgi protein
PNUC_RS09145	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
PNUC_RS09150	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
PNUC_RS09155	COG0628	permease
PNUC_RS09170	COG0617	tRNA 3'-terminal CCA addition
PNUC_RS09175	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
PNUC_RS09180	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
PNUC_RS09185	COG0484	heat shock protein binding
PNUC_RS09190	COG0443	Heat shock 70 kDa protein
PNUC_RS09195	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
PNUC_RS09200	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
PNUC_RS09205	COG1420	regulation of RNA biosynthetic process
PNUC_RS09210	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
PNUC_RS09215	COG0497	DNA recombination
PNUC_RS09220	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
PNUC_RS09230	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PNUC_RS09235	COG0312	modulator of DNA gyrase
PNUC_RS09240	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
PNUC_RS09245	COG2096	Adenosyltransferase
PNUC_RS09250	COG0277	FAD linked oxidase domain protein
PNUC_RS09255	COG0277	FAD linked oxidase domain protein
PNUC_RS09260	COG0247	lactate metabolic process
PNUC_RS09265	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
PNUC_RS09275	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
PNUC_RS09280	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
PNUC_RS09285	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
PNUC_RS09290	COG0343	queuine tRNA-ribosyltransferase activity
PNUC_RS09295	COG1862	Preprotein translocase
PNUC_RS09300	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
PNUC_RS09305	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
PNUC_RS09320	COG0625	glutathione transferase activity
PNUC_RS09325	COG0482	sulfurtransferase activity
PNUC_RS09370	COG0459	protein refolding
PNUC_RS09375	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
PNUC_RS09385	COG2197	response regulator
PNUC_RS09390	COG0784	Response regulator, receiver
PNUC_RS09390	COG2198	Histidine kinase
PNUC_RS09390	COG2205	protein histidine kinase activity
PNUC_RS09390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PNUC_RS09395	COG2027	D-alanyl-D-alanine carboxypeptidase
PNUC_RS09400	COG0009	L-threonylcarbamoyladenylate synthase
PNUC_RS09405	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
PNUC_RS09410	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
PNUC_RS09415	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
PNUC_RS09425	COG0469	pyruvate kinase activity
PNUC_RS09430	COG0126	phosphoglycerate kinase activity
PNUC_RS09445	COG0859	PFAM glycosyl transferase family 9
PNUC_RS09460	COG4783	chaperone-mediated protein folding
PNUC_RS09465	COG0315	cyclic pyranopterin monophosphate synthase activity
PNUC_RS09490	COG0861	Integral membrane protein TerC family
PNUC_RS09495	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
PNUC_RS09500	COG0045	succinate-CoA ligase (ADP-forming) activity
PNUC_RS09505	COG2137	regulation of response to DNA damage stimulus
PNUC_RS09510	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
PNUC_RS09540	COG4974	Belongs to the 'phage' integrase family
PNUC_RS09595	COG2258	MOSC domain
PNUC_RS09600	COG0477	Major facilitator Superfamily
PNUC_RS09600	COG0477	Major facilitator Superfamily
PNUC_RS09610	COG0625	glutathione transferase activity
PNUC_RS09645	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
PNUC_RS09650	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
PNUC_RS09660	COG0815	Transfers the fatty acyl group on membrane lipoproteins
PNUC_RS09665	COG0752	glycyl-tRNA synthetase alpha subunit
PNUC_RS09670	COG0751	glycine-tRNA ligase activity
PNUC_RS09675	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
PNUC_RS09680	COG0204	Acyl-transferase
PNUC_RS09685	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
PNUC_RS09690	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
PNUC_RS09695	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PNUC_RS09700	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
PNUC_RS09715	COG0006	proline dipeptidase activity
PNUC_RS09720	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PNUC_RS09730	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
PNUC_RS09735	COG0138	bifunctional purine biosynthesis protein purh
PNUC_RS09740	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
PNUC_RS09745	COG0632	four-way junction helicase activity
PNUC_RS09750	COG2255	four-way junction helicase activity
PNUC_RS09755	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
PNUC_RS09760	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
PNUC_RS09765	COG0316	Belongs to the HesB IscA family
PNUC_RS09770	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
PNUC_RS09775	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
PNUC_RS09780	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
PNUC_RS09785	COG1765	OsmC-like protein
PNUC_RS09790	COG0418	dihydroorotase activity
PNUC_RS09800	COG5265	(ABC) transporter
PNUC_RS09810	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
PNUC_RS09820	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
PNUC_RS09835	COG2226	methyltransferase
PNUC_RS09850	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
PNUC_RS09860	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
PNUC_RS09860	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
PNUC_RS09865	COG0629	single-stranded DNA binding
PNUC_RS09870	COG2814	Major facilitator Superfamily
PNUC_RS09890	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
PNUC_RS09905	COG1137	ATPase activity
PNUC_RS09910	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
PNUC_RS09920	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
PNUC_RS09925	COG1660	Displays ATPase and GTPase activities
PNUC_RS09930	COG1194	a g-specific adenine glycosylase
PNUC_RS09935	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
PNUC_RS09945	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
PNUC_RS09955	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
PNUC_RS09960	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
PNUC_RS09965	COG0193	aminoacyl-tRNA hydrolase activity
PNUC_RS09970	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
PNUC_RS09975	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
PNUC_RS09980	COG0742	ribosomal rna small subunit methyltransferase
PNUC_RS09985	COG0612	Peptidase, M16
PNUC_RS09990	COG0612	Peptidase, M16
PNUC_RS10000	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
PNUC_RS10005	COG1999	signal sequence binding
PNUC_RS10010	COG0109	protoheme IX farnesyltransferase activity
PNUC_RS10015	COG1612	heme a metabolic process
PNUC_RS10045	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
PNUC_RS10050	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
PNUC_RS10060	COG2226	methyltransferase
PNUC_RS10070	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
PNUC_RS10075	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
PNUC_RS10080	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
PNUC_RS10090	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
PNUC_RS10095	COG0588	phosphoglycerate mutase activity
PNUC_RS10100	COG0793	Belongs to the peptidase S41A family
PNUC_RS10105	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
PNUC_RS10110	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
PNUC_RS10115	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
PNUC_RS10125	COG0189	ligase activity
PNUC_RS10135	COG0004	ammonium transporteR
PNUC_RS10150	COG2960	long-chain fatty acid transporting porin activity
PNUC_RS10160	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
PNUC_RS10165	COG0321	lipoyl(octanoyl) transferase activity
PNUC_RS10170	COG2921	Belongs to the UPF0250 family
PNUC_RS10175	COG2945	thiolester hydrolase activity
PNUC_RS10190	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
PNUC_RS10190	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
PNUC_RS10195	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
PNUC_RS10200	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
PNUC_RS10205	COG0386	Belongs to the glutathione peroxidase family
PNUC_RS10220	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
PNUC_RS10225	COG0300	oxidoreductase activity
PNUC_RS10230	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
PNUC_RS10240	COG0018	arginyl-trna synthetase
PNUC_RS10250	COG1410	methionine synthase
PNUC_RS10250	COG0646	methionine synthase
PNUC_RS10255	COG0646	methionine synthase
PNUC_RS10255	COG1410	methionine synthase
PNUC_RS10270	COG0604	alcohol dehydrogenase
PNUC_RS10280	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
PNUC_RS10285	COG0625	glutathione transferase activity
PNUC_RS10290	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PNUC_RS10295	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PNUC_RS10300	COG1538	Outer membrane efflux protein
PNUC_RS10305	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
PNUC_RS10310	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
PNUC_RS10315	COG0037	tRNA processing
PNUC_RS10335	COG0617	tRNA 3'-terminal CCA addition
PNUC_RS10360	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
PNUC_RS10365	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
PNUC_RS10380	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
PNUC_RS10385	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
PNUC_RS10390	COG0708	Exodeoxyribonuclease III
PNUC_RS10395	COG2211	Major facilitator Superfamily
PNUC_RS10415	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
PNUC_RS10425	COG0523	cobalamin synthesis protein
PNUC_RS10430	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
PNUC_RS10440	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
PNUC_RS10445	COG0154	amidase activity
PNUC_RS10450	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
PNUC_RS10455	COG1077	Cell shape determining protein MreB Mrl
PNUC_RS10470	COG0768	penicillin binding
PNUC_RS10475	COG0772	Belongs to the SEDS family
PNUC_RS10500	COG0288	reversible hydration of carbon dioxide
PNUC_RS10505	COG1560	Kdo2-lipid A biosynthetic process
PNUC_RS10520	COG1301	dicarboxylic acid transport
PNUC_RS10525	COG1187	pseudouridine synthase activity
PNUC_RS10530	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
PNUC_RS10560	COG3713	MltA-interacting MipA family protein
PNUC_RS10565	COG3181	Tripartite tricarboxylate transporter family receptor
PNUC_RS10575	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
PNUC_RS10620	COG0753	catalase activity
PNUC_RS10630	COG0583	DNA-binding transcription factor activity
PNUC_RS10645	COG1573	uracil-dna glycosylase
PNUC_RS10740	COG1944	ATP diphosphatase activity
PNUC_RS10745	COG2204	response regulator
PNUC_RS10750	COG5000	phosphorelay sensor kinase activity
PNUC_RS10760	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
PNUC_RS10760	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
PNUC_RS10765	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
PNUC_RS10770	COG0242	peptide deformylase activity
PNUC_RS10775	COG0758	DNA mediated transformation
PNUC_RS10785	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
PNUC_RS10790	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
PNUC_RS10795	COG0706	membrane insertase activity
PNUC_RS10795	COG4455	Protein of avirulence locus involved in temperature-dependent protein secretion
PNUC_RS10800	COG0594	ribonuclease P activity
PNUC_RS10805	COG0230	Belongs to the bacterial ribosomal protein bL34 family
PNUC_RS10830	COG3437	response regulator, receiver