locus-tag	class	description
DPM16_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DPM16_RS00010	COG0592	DNA-directed DNA polymerase activity
DPM16_RS00030	COG0411	ABC transporter
DPM16_RS00050	COG4214	carbohydrate transport
DPM16_RS00055	COG0445	tRNA wobble uridine modification
DPM16_RS00060	COG0357	Ribosomal RNA small subunit methyltransferase G
DPM16_RS00065	COG1192	Involved in chromosome partitioning
DPM16_RS00080	COG0356	it plays a direct role in the translocation of protons across the membrane
DPM16_RS00090	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DPM16_RS00095	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DPM16_RS00100	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DPM16_RS00105	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DPM16_RS00110	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DPM16_RS00115	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DPM16_RS00120	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
DPM16_RS00125	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DPM16_RS00130	COG0509	glycine decarboxylation via glycine cleavage system
DPM16_RS00135	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DPM16_RS00165	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
DPM16_RS00170	COG2823	Periplasmic or secreted lipoprotein
DPM16_RS00175	COG4654	Cytochrome c, class I
DPM16_RS00225	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DPM16_RS00235	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DPM16_RS00245	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DPM16_RS00250	COG0081	regulation of translation
DPM16_RS00255	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DPM16_RS00260	COG0222	ribosome binding
DPM16_RS00265	COG0085	RNA polymerase activity
DPM16_RS00270	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DPM16_RS00275	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DPM16_RS00280	COG0049	tRNA binding
DPM16_RS00285	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DPM16_RS00290	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DPM16_RS00295	COG0051	transcription antitermination factor activity, RNA binding
DPM16_RS00300	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DPM16_RS00305	COG0088	Forms part of the polypeptide exit tunnel
DPM16_RS00310	COG0089	rRNA binding
DPM16_RS00315	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DPM16_RS00320	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DPM16_RS00325	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DPM16_RS00330	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DPM16_RS00335	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DPM16_RS00340	COG0255	Belongs to the universal ribosomal protein uL29 family
DPM16_RS00345	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DPM16_RS00350	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DPM16_RS00355	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DPM16_RS00360	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DPM16_RS00365	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DPM16_RS00370	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DPM16_RS00375	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DPM16_RS00380	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DPM16_RS00385	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DPM16_RS00390	COG1841	ribosomal large subunit assembly
DPM16_RS00395	COG0200	Binds to the 23S rRNA
DPM16_RS00400	COG0201	protein transport
DPM16_RS00405	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DPM16_RS00410	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DPM16_RS00415	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DPM16_RS00420	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DPM16_RS00425	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DPM16_RS00430	COG0202	RNA polymerase activity
DPM16_RS00435	COG0203	ribosomal protein L17
DPM16_RS00440	COG1324	tolerance protein
DPM16_RS00445	COG4232	protein-disulfide reductase activity
DPM16_RS00450	COG0113	porphobilinogen synthase activity
DPM16_RS00455	COG0218	Necessary for normal cell division and for the maintenance of normal septation
DPM16_RS00465	COG0019	diaminopimelate decarboxylase activity
DPM16_RS00475	COG1965	Belongs to the frataxin family
DPM16_RS00510	COG0070	glutamate synthase
DPM16_RS00510	COG0069	glutamate synthase activity
DPM16_RS00510	COG0067	glutamate synthase
DPM16_RS00520	COG1127	ABC transporter
DPM16_RS00525	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DPM16_RS00530	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DPM16_RS00535	COG2853	Lipoprotein
DPM16_RS00550	COG1131	(ABC) transporter
DPM16_RS00555	COG0842	Transport permease protein
DPM16_RS00565	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DPM16_RS00570	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DPM16_RS00575	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DPM16_RS00580	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DPM16_RS00585	COG0131	Imidazoleglycerol-phosphate dehydratase
DPM16_RS00590	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DPM16_RS00595	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DPM16_RS00600	COG0107	imidazoleglycerol-phosphate synthase activity
DPM16_RS00605	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DPM16_RS00620	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DPM16_RS00625	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DPM16_RS00630	COG0805	protein transport
DPM16_RS00640	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
DPM16_RS00650	COG0765	amino acid transport
DPM16_RS00655	COG0765	amino acid transport
DPM16_RS00660	COG1126	abc transporter atp-binding protein
DPM16_RS00665	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DPM16_RS00670	COG1970	mechanosensitive ion channel activity
DPM16_RS00675	COG0723	plastoquinol--plastocyanin reductase activity
DPM16_RS00680	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DPM16_RS00685	COG2857	Cytochrome c1
DPM16_RS00690	COG0625	glutathione transferase activity
DPM16_RS00705	COG0457	Tetratricopeptide repeat
DPM16_RS00705	COG0859	PFAM glycosyl transferase family 9
DPM16_RS00730	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
DPM16_RS00735	COG2890	protein-(glutamine-N5) methyltransferase activity
DPM16_RS00740	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DPM16_RS00745	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DPM16_RS00765	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DPM16_RS00775	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DPM16_RS00780	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DPM16_RS00785	COG0012	GTP binding
DPM16_RS00795	COG0134	indole-3-glycerol-phosphate synthase activity
DPM16_RS00800	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DPM16_RS00815	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DPM16_RS00820	COG2967	ApaG domain
DPM16_RS00835	COG1473	amidohydrolase
DPM16_RS00840	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
DPM16_RS00845	COG0156	8-amino-7-oxononanoate synthase activity
DPM16_RS00855	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DPM16_RS00860	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
DPM16_RS00865	COG2001	Belongs to the MraZ family
DPM16_RS00870	COG0275	rRNA processing
DPM16_RS00885	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DPM16_RS00890	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DPM16_RS00895	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DPM16_RS00900	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DPM16_RS00905	COG0772	Belongs to the SEDS family
DPM16_RS00910	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DPM16_RS00915	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DPM16_RS00920	COG1181	Belongs to the D-alanine--D-alanine ligase family
DPM16_RS00925	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DPM16_RS00940	COG0678	peroxiredoxin activity
DPM16_RS00945	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
DPM16_RS00955	COG0653	protein targeting
DPM16_RS00970	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DPM16_RS00985	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
DPM16_RS00995	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
DPM16_RS01005	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DPM16_RS01010	COG4536	flavin adenine dinucleotide binding
DPM16_RS01020	COG1562	ergosterol biosynthetic process
DPM16_RS01030	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DPM16_RS01045	COG0142	geranyltranstransferase activity
DPM16_RS01050	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DPM16_RS01055	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DPM16_RS01060	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DPM16_RS01075	COG0494	nUDIX hydrolase
DPM16_RS01080	COG0442	prolyl-tRNA aminoacylation
DPM16_RS01085	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DPM16_RS01105	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DPM16_RS01125	COG2264	protein methyltransferase activity
DPM16_RS01130	COG0439	Biotin carboxylase
DPM16_RS01135	COG0511	ligase activity, forming carbon-carbon bonds
DPM16_RS01140	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
DPM16_RS01145	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DPM16_RS01150	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DPM16_RS01155	COG1028	Short-chain dehydrogenase reductase Sdr
DPM16_RS01160	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
DPM16_RS01170	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DPM16_RS01175	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DPM16_RS01180	COG0284	orotidine-5'-phosphate decarboxylase activity
DPM16_RS01195	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
DPM16_RS01215	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DPM16_RS01220	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DPM16_RS01225	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DPM16_RS01230	COG0735	belongs to the Fur family
DPM16_RS01235	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DPM16_RS01240	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DPM16_RS01245	COG0495	leucyl-tRNA aminoacylation
DPM16_RS01260	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DPM16_RS01265	COG1981	membrane
DPM16_RS01275	COG1773	rubredoxin
DPM16_RS01280	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DPM16_RS01285	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DPM16_RS01290	COG0415	Belongs to the DNA photolyase family
DPM16_RS01300	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DPM16_RS01305	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
DPM16_RS01310	COG0540	Belongs to the ATCase OTCase family
DPM16_RS01335	COG1215	transferase activity, transferring glycosyl groups
DPM16_RS01355	COG1091	dTDP-4-dehydrorhamnose reductase activity
DPM16_RS01370	COG0859	PFAM glycosyl transferase family 9
DPM16_RS01380	COG1968	undecaprenyl-diphosphatase activity
DPM16_RS01395	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DPM16_RS01405	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DPM16_RS01410	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DPM16_RS01440	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DPM16_RS01440	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DPM16_RS01450	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DPM16_RS01465	COG0823	Involved in the tonB-independent uptake of proteins
DPM16_RS01475	COG0848	biopolymer transport protein
DPM16_RS01485	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DPM16_RS01490	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DPM16_RS01495	COG0563	adenylate kinase activity
DPM16_RS01500	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
DPM16_RS01505	COG2835	tetraacyldisaccharide 4'-kinase activity
DPM16_RS01510	COG1663	tetraacyldisaccharide 4'-kinase activity
DPM16_RS01515	COG0848	biopolymer transport protein
DPM16_RS01520	COG0811	peptide transport
DPM16_RS01525	COG1570	exodeoxyribonuclease VII activity
DPM16_RS01535	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DPM16_RS01540	COG1666	GTP binding
DPM16_RS01550	COG4974	Belongs to the 'phage' integrase family
DPM16_RS01555	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
DPM16_RS01565	COG0302	gtp cyclohydrolase
DPM16_RS01595	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DPM16_RS01605	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DPM16_RS01625	COG1216	Glycosyl transferase, family 2
DPM16_RS01660	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DPM16_RS01705	COG1215	transferase activity, transferring glycosyl groups
DPM16_RS01730	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DPM16_RS01735	COG0387	Pfam Sodium calcium exchanger
DPM16_RS01745	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DPM16_RS01745	COG1648	precorrin-2 dehydrogenase activity
DPM16_RS01755	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DPM16_RS01795	COG3028	Belongs to the UPF0307 family
DPM16_RS01820	COG0683	leucine binding
DPM16_RS01830	COG0411	ABC transporter
DPM16_RS01845	COG1477	protein flavinylation
DPM16_RS01860	COG3530	Putative quorum-sensing-regulated virulence factor
DPM16_RS01885	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DPM16_RS01890	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
DPM16_RS01900	COG4221	oxidoreductase activity
DPM16_RS01910	COG2154	pterin-4-alpha-carbinolamine dehydratase
DPM16_RS01930	COG0709	Synthesizes selenophosphate from selenide and ATP
DPM16_RS01940	COG2831	hemolysin activation secretion protein
DPM16_RS01965	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DPM16_RS01985	COG1252	NADH dehydrogenase
DPM16_RS02005	COG1403	HNH endonuclease
DPM16_RS02020	COG3046	protein related to deoxyribodipyrimidine photolyase
DPM16_RS02030	COG3634	alkyl hydroperoxide reductase activity
DPM16_RS02040	COG0783	Belongs to the Dps family
DPM16_RS02075	COG0235	Class ii aldolase
DPM16_RS02080	COG1942	4-Oxalocrotonate Tautomerase
DPM16_RS02115	COG2755	lipolytic protein G-D-S-L family
DPM16_RS02115	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DPM16_RS02140	COG0860	N-Acetylmuramoyl-L-alanine amidase
DPM16_RS02145	COG0802	atpase or kinase
DPM16_RS02150	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DPM16_RS02175	COG0247	lactate metabolic process
DPM16_RS02175	COG0277	FAD linked oxidase domain protein
DPM16_RS02180	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DPM16_RS02185	COG3193	protein, possibly involved in utilization of glycolate and propanediol
DPM16_RS02190	COG0513	Belongs to the DEAD box helicase family
DPM16_RS02195	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DPM16_RS02215	COG0463	Glycosyl transferase, family 2
DPM16_RS02220	COG1132	(ABC) transporter
DPM16_RS02225	COG1530	ribonuclease E activity
DPM16_RS02230	COG0424	maF-like protein
DPM16_RS02235	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
DPM16_RS02240	COG0799	negative regulation of ribosome biogenesis
DPM16_RS02245	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DPM16_RS02250	COG0408	coproporphyrinogen oxidase activity
DPM16_RS02255	COG0151	Belongs to the GarS family
DPM16_RS02260	COG0217	transcriptional regulatory protein
DPM16_RS02270	COG2161	toxin-antitoxin pair type II binding
DPM16_RS02275	COG4115	mRNA cleavage
DPM16_RS02280	COG0583	DNA-binding transcription factor activity
DPM16_RS02295	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DPM16_RS02305	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DPM16_RS02315	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DPM16_RS02330	COG0318	PFAM AMP-dependent synthetase and ligase
DPM16_RS02335	COG0730	response to heat
DPM16_RS02355	COG4771	TonB-dependent receptor
DPM16_RS02375	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DPM16_RS02380	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DPM16_RS02385	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DPM16_RS02390	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DPM16_RS02405	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DPM16_RS02410	COG0717	Belongs to the dCTP deaminase family
DPM16_RS02420	COG0165	Argininosuccinate lyase
DPM16_RS02425	COG0181	hydroxymethylbilane synthase activity
DPM16_RS02435	COG3161	chorismate lyase activity
DPM16_RS02440	COG0513	Belongs to the DEAD box helicase family
DPM16_RS02450	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DPM16_RS02455	COG0259	pyridoxamine-phosphate oxidase activity
DPM16_RS02460	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DPM16_RS02465	COG1113	amino acid transport
DPM16_RS02470	COG0686	Belongs to the AlaDH PNT family
DPM16_RS02475	COG2119	membrane
DPM16_RS02480	COG0308	aminopeptidase N
DPM16_RS02485	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
DPM16_RS02495	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DPM16_RS02495	COG0189	ligase activity
DPM16_RS02500	COG1132	(ABC) transporter
DPM16_RS02530	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DPM16_RS02535	COG2847	Copper chaperone PCu(A)C
DPM16_RS02540	COG0129	dihydroxy-acid dehydratase activity
DPM16_RS02550	COG0347	Belongs to the P(II) protein family
DPM16_RS02555	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DPM16_RS02555	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DPM16_RS02560	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
DPM16_RS02575	COG1598	PFAM Uncharacterised protein family UPF0150
DPM16_RS02580	COG0492	ferredoxin-NADP+ reductase activity
DPM16_RS02585	COG1674	ftsk spoiiie
DPM16_RS02590	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
DPM16_RS02595	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DPM16_RS02620	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
DPM16_RS02630	COG0347	Belongs to the P(II) protein family
DPM16_RS02655	COG1950	PFAM Membrane protein of
DPM16_RS02660	COG2900	Belongs to the SlyX family
DPM16_RS02680	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
DPM16_RS02685	COG2827	Endonuclease containing a URI domain
DPM16_RS02690	COG0542	response to heat
DPM16_RS02710	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DPM16_RS02715	COG2878	Part of a membrane complex involved in electron transport
DPM16_RS02730	COG0556	nucleotide-excision repair
DPM16_RS02740	COG1104	cysteine desulfurase activity
DPM16_RS02745	COG0822	iron-sulfur transferase activity
DPM16_RS02755	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
DPM16_RS02760	COG0443	Heat shock 70 kDa protein
DPM16_RS02770	COG2895	sulfate adenylyltransferase (ATP) activity
DPM16_RS02780	COG0175	sulfate reduction
DPM16_RS02785	COG0730	response to heat
DPM16_RS02795	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
DPM16_RS02800	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DPM16_RS02810	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DPM16_RS02825	COG1136	(ABC) transporter
DPM16_RS02830	COG0084	hydrolase, TatD family'
DPM16_RS02850	COG3158	transport of potassium into the cell
DPM16_RS02865	COG2890	protein-(glutamine-N5) methyltransferase activity
DPM16_RS02870	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DPM16_RS02875	COG2171	N-acyltransferase activity
DPM16_RS02890	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DPM16_RS02895	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
DPM16_RS02900	COG0024	Methionine aminopeptidase
DPM16_RS02905	COG0052	Belongs to the universal ribosomal protein uS2 family
DPM16_RS02910	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DPM16_RS02915	COG0528	UMP kinase activity
DPM16_RS02920	COG0233	cytoplasmic translational termination
DPM16_RS02925	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DPM16_RS02940	COG0750	zinc metalloprotease
DPM16_RS02955	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DPM16_RS02960	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DPM16_RS02965	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DPM16_RS02975	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DPM16_RS02980	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DPM16_RS02985	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
DPM16_RS03010	COG2308	Evidence 4 Homologs of previously reported genes of
DPM16_RS03015	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DPM16_RS03020	COG2867	negative regulation of translational initiation
DPM16_RS03025	COG2914	Belongs to the UPF0125 (RnfH) family
DPM16_RS03035	COG0519	Catalyzes the synthesis of GMP from XMP
DPM16_RS03035	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DPM16_RS03050	COG0602	queuosine metabolic process
DPM16_RS03065	COG1619	proteins homologs of microcin C7 resistance protein MccF
DPM16_RS03075	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
DPM16_RS03105	COG0489	protein tyrosine kinase activity
DPM16_RS03110	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DPM16_RS03115	COG4662	Binding-protein-dependent transport system inner membrane component
DPM16_RS03125	COG3568	Endonuclease Exonuclease Phosphatase
DPM16_RS03135	COG1238	metal cluster binding
DPM16_RS03140	COG1028	Short-chain dehydrogenase reductase Sdr
DPM16_RS03150	COG1902	pentaerythritol trinitrate reductase activity
DPM16_RS03160	COG3038	cytochrome b561
DPM16_RS03175	COG1304	FMN binding
DPM16_RS03195	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DPM16_RS03195	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DPM16_RS03200	COG1611	Belongs to the LOG family
DPM16_RS03210	COG2081	HI0933 family
DPM16_RS03215	COG0861	Integral membrane protein TerC family
DPM16_RS03235	COG0179	Fumarylacetoacetate (FAA) hydrolase
DPM16_RS03265	COG2223	nitrite transmembrane transporter activity
DPM16_RS03280	COG1918	ferrous iron import across plasma membrane
DPM16_RS03280	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
DPM16_RS03300	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
DPM16_RS03320	COG0534	Mate efflux family protein
DPM16_RS03330	COG0254	rRNA binding
DPM16_RS03335	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DPM16_RS03350	COG1074	ATP-dependent DNA helicase activity
DPM16_RS03375	COG3077	Addiction module antitoxin, RelB DinJ family
DPM16_RS03380	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DPM16_RS03410	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DPM16_RS03415	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DPM16_RS03420	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DPM16_RS03435	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DPM16_RS03445	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
DPM16_RS03450	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DPM16_RS03465	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DPM16_RS03475	COG0105	UTP biosynthetic process
DPM16_RS03480	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DPM16_RS03485	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DPM16_RS03490	COG0124	histidyl-tRNA synthetase
DPM16_RS03505	COG1160	GTP binding
DPM16_RS03510	COG1923	regulation of RNA biosynthetic process
DPM16_RS03515	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DPM16_RS03525	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
DPM16_RS03530	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DPM16_RS03535	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
DPM16_RS03565	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DPM16_RS03580	COG0557	exoribonuclease II activity
DPM16_RS03585	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DPM16_RS03590	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DPM16_RS03595	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
DPM16_RS03600	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
DPM16_RS03605	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DPM16_RS03605	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
DPM16_RS03610	COG1643	Atp-dependent helicase
DPM16_RS03635	COG1546	Belongs to the CinA family
DPM16_RS03635	COG1058	Belongs to the CinA family
DPM16_RS03640	COG0174	glutamine synthetase
DPM16_RS03645	COG3852	Histidine kinase
DPM16_RS03660	COG0339	signal peptide processing
DPM16_RS03665	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DPM16_RS03670	COG4566	intracellular signal transduction
DPM16_RS03680	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
DPM16_RS03685	COG0508	dehydrogenase complex catalyzes the overall conversion of
DPM16_RS03690	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DPM16_RS03715	COG0167	dihydroorotate dehydrogenase activity
DPM16_RS03720	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
DPM16_RS03725	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
DPM16_RS03735	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DPM16_RS03740	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DPM16_RS03745	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DPM16_RS03755	COG1250	3-hydroxyacyl-CoA dehydrogenase
DPM16_RS03760	COG0625	glutathione transferase activity
DPM16_RS03765	COG3022	response to hydroperoxide
DPM16_RS03780	COG0039	L-malate dehydrogenase activity
DPM16_RS03785	COG2188	Transcriptional regulator
DPM16_RS03795	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
DPM16_RS03800	COG1053	succinate dehydrogenase
DPM16_RS03805	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DPM16_RS03810	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
DPM16_RS03815	COG0372	Belongs to the citrate synthase family
DPM16_RS03820	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DPM16_RS03830	COG0066	3-isopropylmalate dehydratase activity
DPM16_RS03835	COG0473	3-isopropylmalate dehydrogenase activity
DPM16_RS03850	COG0101	tRNA pseudouridine synthase activity
DPM16_RS03855	COG0135	phosphoribosylanthranilate isomerase activity
DPM16_RS03860	COG0133	tryptophan synthase activity
DPM16_RS03865	COG0159	tryptophan synthase activity
DPM16_RS03870	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
DPM16_RS03875	COG0285	dihydrofolate synthase activity
DPM16_RS03900	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
DPM16_RS03950	COG3453	Protein conserved in bacteria
DPM16_RS03950	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DPM16_RS03960	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
DPM16_RS03970	COG0488	(ABC) transporter
DPM16_RS03985	COG0346	lactoylglutathione lyase activity
DPM16_RS03995	COG2917	probably involved in intracellular septation
DPM16_RS04000	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DPM16_RS04020	COG0354	folic acid binding
DPM16_RS04025	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DPM16_RS04035	COG0470	DNA polymerase III
DPM16_RS04040	COG0084	hydrolase, TatD family'
DPM16_RS04065	COG2084	Dehydrogenase
DPM16_RS04075	COG3622	Belongs to the hyi family
DPM16_RS04085	COG0501	Belongs to the peptidase M48B family
DPM16_RS04100	COG1647	Serine aminopeptidase, S33
DPM16_RS04130	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DPM16_RS04135	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
DPM16_RS04140	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
DPM16_RS04145	COG0148	phosphopyruvate hydratase activity
DPM16_RS04150	COG2877	3-deoxy-8-phosphooctulonate synthase activity
DPM16_RS04155	COG0504	CTP synthase activity
DPM16_RS04170	COG1049	propionate catabolic process, 2-methylcitrate cycle
DPM16_RS04175	COG4106	trans-aconitate 2-methyltransferase activity
DPM16_RS04180	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DPM16_RS04180	COG0047	phosphoribosylformylglycinamidine synthase activity
DPM16_RS04195	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DPM16_RS04200	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DPM16_RS04205	COG0740	serine-type endopeptidase activity
DPM16_RS04210	COG0544	peptidyl-prolyl cis-trans isomerase activity
DPM16_RS04220	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DPM16_RS04225	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DPM16_RS04230	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DPM16_RS04235	COG0560	Phosphoserine phosphatase
DPM16_RS04240	COG0183	Belongs to the thiolase family
DPM16_RS04245	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DPM16_RS04250	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
DPM16_RS04255	COG1028	Short-chain dehydrogenase reductase Sdr
DPM16_RS04260	COG3243	poly(R)-hydroxyalkanoic acid synthase
DPM16_RS04265	COG1496	oxidoreductase activity
DPM16_RS04270	COG0564	pseudouridine synthase activity
DPM16_RS04280	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DPM16_RS04295	COG0456	acetyltransferase
DPM16_RS04300	COG1214	PFAM Peptidase M22, glycoprotease
DPM16_RS04310	COG4770	biotin carboxylase activity
DPM16_RS04315	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DPM16_RS04320	COG1703	isobutyryl-CoA mutase activity
DPM16_RS04325	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DPM16_RS04325	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DPM16_RS04330	COG1802	Transcriptional regulator
DPM16_RS04360	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DPM16_RS04375	COG1051	belongs to the nudix hydrolase family
DPM16_RS04380	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
DPM16_RS04395	COG2022	thiamine diphosphate biosynthetic process
DPM16_RS04405	COG0351	phosphomethylpyrimidine kinase
DPM16_RS04425	COG0318	PFAM AMP-dependent synthetase and ligase
DPM16_RS04440	COG4575	ribosome binding
DPM16_RS04455	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DPM16_RS04460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DPM16_RS04475	COG0527	aspartate kinase activity
DPM16_RS04480	COG0037	tRNA processing
DPM16_RS04485	COG0825	malonyl-CoA metabolic process
DPM16_RS04495	COG0215	cysteine-tRNA ligase activity
DPM16_RS04505	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DPM16_RS04510	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DPM16_RS04515	COG0483	inositol monophosphate 1-phosphatase activity
DPM16_RS04525	COG1045	serine acetyltransferase
DPM16_RS04535	COG2850	peptidyl-arginine hydroxylation
DPM16_RS04540	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
DPM16_RS04545	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DPM16_RS04555	COG0180	Tryptophanyl-tRNA synthetase
DPM16_RS04560	COG0613	PHP domain protein
DPM16_RS04565	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
DPM16_RS04570	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DPM16_RS04575	COG0508	dehydrogenase complex catalyzes the overall conversion of
DPM16_RS04580	COG0567	Dehydrogenase, E1 component
DPM16_RS04590	COG2916	Histone family protein nucleoid-structuring protein H-NS
DPM16_RS04605	COG0789	Transcriptional regulator
DPM16_RS04610	COG0776	regulation of translation
DPM16_RS04615	COG0072	phenylalanine-tRNA ligase activity
DPM16_RS04615	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DPM16_RS04620	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DPM16_RS04625	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DPM16_RS04630	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DPM16_RS04635	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DPM16_RS04640	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DPM16_RS04650	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DPM16_RS04680	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DPM16_RS04685	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DPM16_RS04685	COG3620	sequence-specific DNA binding
DPM16_RS04685	COG0617	tRNA 3'-terminal CCA addition
DPM16_RS04690	COG1295	ribonuclease BN
DPM16_RS04810	COG0438	transferase activity, transferring glycosyl groups
DPM16_RS04815	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
DPM16_RS04825	COG0248	Ppx GppA phosphatase
DPM16_RS04860	COG1285	pathogenesis
DPM16_RS04875	COG0745	RESPONSE REGULATOR receiver
DPM16_RS04885	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DPM16_RS04890	COG0581	inorganic phosphate transmembrane transporter activity
DPM16_RS04895	COG0573	inorganic phosphate transmembrane transporter activity
DPM16_RS04900	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DPM16_RS04905	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DPM16_RS04920	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
DPM16_RS04935	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DPM16_RS04940	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DPM16_RS04945	COG0505	Belongs to the CarA family
DPM16_RS04950	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DPM16_RS04955	COG1388	LysM domain
DPM16_RS04955	COG0741	lytic transglycosylase activity
DPM16_RS04960	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DPM16_RS04965	COG2226	methyltransferase
DPM16_RS04970	COG0328	RNA-DNA hybrid ribonuclease activity
DPM16_RS04975	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DPM16_RS04990	COG0473	3-isopropylmalate dehydrogenase activity
DPM16_RS05000	COG1902	pentaerythritol trinitrate reductase activity
DPM16_RS05020	COG1007	ATP synthesis coupled electron transport
DPM16_RS05035	COG0713	ATP synthesis coupled electron transport
DPM16_RS05045	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DPM16_RS05050	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DPM16_RS05055	COG1034	ATP synthesis coupled electron transport
DPM16_RS05070	COG0649	NAD binding
DPM16_RS05075	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DPM16_RS05080	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DPM16_RS05085	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DPM16_RS05095	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DPM16_RS05100	COG0149	triose-phosphate isomerase activity
DPM16_RS05110	COG1185	polyribonucleotide nucleotidyltransferase activity
DPM16_RS05115	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DPM16_RS05125	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DPM16_RS05130	COG1183	phosphatidylcholine synthase activity
DPM16_RS05135	COG0688	phosphatidylethanolamine metabolic process
DPM16_RS05140	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DPM16_RS05145	COG0440	acetolactate synthase activity
DPM16_RS05150	COG0028	Belongs to the TPP enzyme family
DPM16_RS05180	COG3008	intermembrane lipid transfer
DPM16_RS05180	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DPM16_RS05185	COG1127	ABC transporter
DPM16_RS05190	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DPM16_RS05205	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DPM16_RS05210	COG1758	RNA polymerase activity
DPM16_RS05215	COG0194	GDP metabolic process
DPM16_RS05220	COG1561	YicC-like family, N-terminal region
DPM16_RS05225	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DPM16_RS05230	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DPM16_RS05235	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DPM16_RS05240	COG1024	Enoyl-CoA hydratase
DPM16_RS05240	COG1250	3-hydroxyacyl-CoA dehydrogenase
DPM16_RS05245	COG3181	Tripartite tricarboxylate transporter family receptor
DPM16_RS05250	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DPM16_RS05260	COG3622	Belongs to the hyi family
DPM16_RS05265	COG3960	tartronate-semialdehyde synthase activity
DPM16_RS05270	COG0583	DNA-binding transcription factor activity
DPM16_RS05280	COG0166	Belongs to the GPI family
DPM16_RS05310	COG4566	intracellular signal transduction
DPM16_RS05325	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DPM16_RS05335	COG3657	addiction module killer protein
DPM16_RS05340	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DPM16_RS05350	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DPM16_RS05365	COG3383	formate dehydrogenase (NAD+) activity
DPM16_RS05380	COG3608	succinylglutamate desuccinylase aspartoacylase
DPM16_RS05380	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
DPM16_RS05385	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DPM16_RS05390	COG0450	alkyl hydroperoxide reductase
DPM16_RS05405	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DPM16_RS05415	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DPM16_RS05465	COG3258	Cytochrome c
DPM16_RS05485	COG2010	Cytochrome c
DPM16_RS05485	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DPM16_RS05505	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DPM16_RS05515	COG0730	response to heat
DPM16_RS05520	COG2814	Major facilitator Superfamily
DPM16_RS05535	COG1217	gtp-binding protein TYPA
DPM16_RS05545	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DPM16_RS05550	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DPM16_RS05555	COG0195	Participates in both transcription termination and antitermination
DPM16_RS05555	COG2251	uridine kinase activity
DPM16_RS05560	COG0779	Required for maturation of 30S ribosomal subunits
DPM16_RS05565	COG1187	pseudouridine synthase activity
DPM16_RS05570	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DPM16_RS05575	COG1752	Esterase of the alpha-beta hydrolase superfamily
DPM16_RS05580	COG0791	NLP P60 protein
DPM16_RS05585	COG4172	Belongs to the ABC transporter superfamily
DPM16_RS05590	COG4239	(ABC) transporter, permease
DPM16_RS05595	COG4174	ABC transporter (Permease)
DPM16_RS05600	COG4166	transmembrane transport
DPM16_RS05640	COG0446	pyridine nucleotide-disulphide oxidoreductase
DPM16_RS05650	COG0789	Transcriptional regulator
DPM16_RS05655	COG0488	(ABC) transporter
DPM16_RS05660	COG0314	molybdopterin synthase activity
DPM16_RS05670	COG0303	'Molybdopterin
DPM16_RS05685	COG0436	Aminotransferase
DPM16_RS05700	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DPM16_RS05710	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DPM16_RS05710	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DPM16_RS05720	COG0726	polysaccharide deacetylase
DPM16_RS05725	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DPM16_RS05730	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
DPM16_RS05735	COG0791	NLP P60 protein
DPM16_RS05745	COG0359	binds to the 23S rRNA
DPM16_RS05750	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DPM16_RS05760	COG0360	Binds together with S18 to 16S ribosomal RNA
DPM16_RS05765	COG0252	asparaginase activity
DPM16_RS05770	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DPM16_RS05805	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DPM16_RS05815	COG0736	holo-[acyl-carrier-protein] synthase activity
DPM16_RS05820	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
DPM16_RS05825	COG1381	Involved in DNA repair and RecF pathway recombination
DPM16_RS05830	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DPM16_RS05835	COG0571	ribonuclease III activity
DPM16_RS05840	COG0681	Belongs to the peptidase S26 family
DPM16_RS05845	COG0481	GTPase activity
DPM16_RS05850	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DPM16_RS05855	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DPM16_RS05860	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DPM16_RS05870	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DPM16_RS05875	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DPM16_RS05880	COG0416	fatty acid biosynthetic process
DPM16_RS05885	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DPM16_RS05895	COG0424	maF-like protein
DPM16_RS05900	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DPM16_RS05910	COG0546	phosphoglycolate phosphatase activity
DPM16_RS05915	COG0564	pseudouridine synthase activity
DPM16_RS05920	COG1530	ribonuclease E activity
DPM16_RS05925	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DPM16_RS05930	COG0746	molybdenum cofactor guanylyltransferase activity
DPM16_RS05935	COG0303	'Molybdopterin
DPM16_RS05945	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DPM16_RS05950	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
DPM16_RS05955	COG0492	ferredoxin-NADP+ reductase activity
DPM16_RS05960	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
DPM16_RS05970	COG0312	modulator of DNA gyrase
DPM16_RS05975	COG0521	Mo-molybdopterin cofactor biosynthetic process
DPM16_RS05980	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
DPM16_RS05985	COG0501	Belongs to the peptidase M48B family
DPM16_RS05990	COG1162	GTPase activity
DPM16_RS05995	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
DPM16_RS06005	COG0335	large ribosomal subunit rRNA binding
DPM16_RS06010	COG0336	Belongs to the RNA methyltransferase TrmD family
DPM16_RS06015	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DPM16_RS06020	COG0228	four-way junction DNA binding
DPM16_RS06045	COG0123	including yeast histone deacetylase and acetoin utilization protein
DPM16_RS06050	COG2951	lytic endotransglycosylase activity
DPM16_RS06065	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DPM16_RS06070	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
DPM16_RS06080	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
DPM16_RS06085	COG0776	regulation of translation
DPM16_RS06095	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DPM16_RS06100	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DPM16_RS06105	COG0287	Prephenate dehydrogenase
DPM16_RS06110	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DPM16_RS06120	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
DPM16_RS06135	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DPM16_RS06140	COG0546	phosphoglycolate phosphatase activity
DPM16_RS06155	COG2264	protein methyltransferase activity
DPM16_RS06165	COG3181	Tripartite tricarboxylate transporter family receptor
DPM16_RS06170	COG1054	Belongs to the UPF0176 family
DPM16_RS06190	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DPM16_RS06210	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DPM16_RS06215	COG3384	dioxygenase
DPM16_RS06220	COG1994	Peptidase M50
DPM16_RS06230	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DPM16_RS06235	COG0739	heme binding
DPM16_RS06265	COG1028	Short-chain dehydrogenase reductase Sdr
DPM16_RS06270	COG4235	cytochrome complex assembly
DPM16_RS06275	COG3088	subunit of a heme lyase
DPM16_RS06280	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DPM16_RS06290	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
DPM16_RS06310	COG4133	protoheme IX ABC transporter activity
DPM16_RS06345	COG1741	Belongs to the pirin family
DPM16_RS06355	COG0069	glutamate synthase activity
DPM16_RS06375	COG0477	Major facilitator Superfamily
DPM16_RS06385	COG1294	oxidase, subunit
DPM16_RS06390	COG1271	oxidase subunit
DPM16_RS06395	COG1113	amino acid transport
DPM16_RS06400	COG0181	hydroxymethylbilane synthase activity
DPM16_RS06410	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DPM16_RS06430	COG0828	Belongs to the bacterial ribosomal protein bS21 family
DPM16_RS06435	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DPM16_RS06440	COG1469	GTP cyclohydrolase I activity
DPM16_RS06445	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DPM16_RS06450	COG0142	geranyltranstransferase activity
DPM16_RS06455	COG1722	exodeoxyribonuclease VII activity
DPM16_RS06490	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DPM16_RS06500	COG0210	DNA helicase
DPM16_RS06505	COG0525	valine-tRNA ligase activity
DPM16_RS06510	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DPM16_RS06515	COG0425	Belongs to the sulfur carrier protein TusA family
DPM16_RS06520	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DPM16_RS06535	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DPM16_RS06550	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DPM16_RS06555	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DPM16_RS06565	COG2003	Belongs to the UPF0758 family
DPM16_RS06570	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DPM16_RS06575	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DPM16_RS06585	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DPM16_RS06585	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DPM16_RS06590	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DPM16_RS06595	COG0196	riboflavin kinase activity
DPM16_RS06600	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DPM16_RS06605	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DPM16_RS06615	COG0756	dUTP diphosphatase activity
DPM16_RS06625	COG0542	response to heat
DPM16_RS06630	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
DPM16_RS06635	COG1278	Cold shock
DPM16_RS06645	COG3123	guanosine phosphorylase activity
DPM16_RS06650	COG0137	argininosuccinate synthase activity
DPM16_RS06655	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DPM16_RS06665	COG0268	Binds directly to 16S ribosomal RNA
DPM16_RS06670	COG0728	peptidoglycan biosynthetic process
DPM16_RS06680	COG0586	Pfam SNARE associated Golgi protein
DPM16_RS06685	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DPM16_RS06690	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DPM16_RS06695	COG0628	permease
DPM16_RS06710	COG0617	tRNA 3'-terminal CCA addition
DPM16_RS06715	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DPM16_RS06720	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DPM16_RS06730	COG0443	Heat shock 70 kDa protein
DPM16_RS06735	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DPM16_RS06740	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
DPM16_RS06745	COG1420	regulation of RNA biosynthetic process
DPM16_RS06750	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DPM16_RS06755	COG0497	DNA recombination
DPM16_RS06760	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
DPM16_RS06775	COG0312	modulator of DNA gyrase
DPM16_RS06780	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DPM16_RS06785	COG2096	Adenosyltransferase
DPM16_RS06790	COG0277	FAD linked oxidase domain protein
DPM16_RS06795	COG0277	FAD linked oxidase domain protein
DPM16_RS06800	COG0247	lactate metabolic process
DPM16_RS06815	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
DPM16_RS06825	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DPM16_RS06830	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DPM16_RS06835	COG0343	queuine tRNA-ribosyltransferase activity
DPM16_RS06840	COG1862	Preprotein translocase
DPM16_RS06845	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DPM16_RS06850	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DPM16_RS06865	COG0625	glutathione transferase activity
DPM16_RS06870	COG0482	sulfurtransferase activity
DPM16_RS06880	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
DPM16_RS06895	COG0459	protein refolding
DPM16_RS06900	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DPM16_RS06910	COG2197	response regulator
DPM16_RS06915	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DPM16_RS06915	COG2205	protein histidine kinase activity
DPM16_RS06925	COG0009	L-threonylcarbamoyladenylate synthase
DPM16_RS06930	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
DPM16_RS06935	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DPM16_RS06940	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DPM16_RS06950	COG0469	pyruvate kinase activity
DPM16_RS06955	COG0126	phosphoglycerate kinase activity
DPM16_RS06970	COG0859	PFAM glycosyl transferase family 9
DPM16_RS06985	COG0315	cyclic pyranopterin monophosphate synthase activity
DPM16_RS06995	COG0861	Integral membrane protein TerC family
DPM16_RS07000	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
DPM16_RS07005	COG0045	succinate-CoA ligase (ADP-forming) activity
DPM16_RS07010	COG2137	regulation of response to DNA damage stimulus
DPM16_RS07015	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DPM16_RS07030	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DPM16_RS07040	COG2258	MOSC domain
DPM16_RS07045	COG0477	Major facilitator Superfamily
DPM16_RS07045	COG0477	Major facilitator Superfamily
DPM16_RS07085	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DPM16_RS07090	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DPM16_RS07100	COG0815	Transfers the fatty acyl group on membrane lipoproteins
DPM16_RS07105	COG0752	glycyl-tRNA synthetase alpha subunit
DPM16_RS07110	COG0751	glycine-tRNA ligase activity
DPM16_RS07115	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
DPM16_RS07120	COG0204	Acyl-transferase
DPM16_RS07130	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
DPM16_RS07135	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DPM16_RS07140	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
DPM16_RS07150	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DPM16_RS07155	COG0006	proline dipeptidase activity
DPM16_RS07160	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DPM16_RS07170	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
DPM16_RS07175	COG0138	bifunctional purine biosynthesis protein purh
DPM16_RS07180	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
DPM16_RS07185	COG0632	four-way junction helicase activity
DPM16_RS07190	COG2255	four-way junction helicase activity
DPM16_RS07195	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DPM16_RS07200	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
DPM16_RS07205	COG0316	Belongs to the HesB IscA family
DPM16_RS07210	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DPM16_RS07215	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DPM16_RS07220	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DPM16_RS07225	COG1765	OsmC-like protein
DPM16_RS07235	COG0418	dihydroorotase activity
DPM16_RS07245	COG5265	(ABC) transporter
DPM16_RS07265	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DPM16_RS07280	COG2226	methyltransferase
DPM16_RS07295	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DPM16_RS07305	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DPM16_RS07305	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DPM16_RS07310	COG0629	single-stranded DNA binding
DPM16_RS07315	COG2814	Major facilitator Superfamily
DPM16_RS07335	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
DPM16_RS07350	COG1137	ATPase activity
DPM16_RS07355	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DPM16_RS07365	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
DPM16_RS07370	COG1660	Displays ATPase and GTPase activities
DPM16_RS07375	COG1194	a g-specific adenine glycosylase
DPM16_RS07380	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DPM16_RS07390	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DPM16_RS07400	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DPM16_RS07405	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DPM16_RS07410	COG0193	aminoacyl-tRNA hydrolase activity
DPM16_RS07415	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
DPM16_RS07420	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DPM16_RS07425	COG0742	ribosomal rna small subunit methyltransferase
DPM16_RS07430	COG0612	Peptidase, M16
DPM16_RS07435	COG0612	Peptidase, M16
DPM16_RS07445	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DPM16_RS07450	COG1999	signal sequence binding
DPM16_RS07455	COG0109	protoheme IX farnesyltransferase activity
DPM16_RS07460	COG1612	heme a metabolic process
DPM16_RS07490	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
DPM16_RS07495	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DPM16_RS07505	COG2226	methyltransferase
DPM16_RS07510	COG1040	competence protein
DPM16_RS07515	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DPM16_RS07520	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DPM16_RS07525	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
DPM16_RS07540	COG0588	phosphoglycerate mutase activity
DPM16_RS07545	COG0793	Belongs to the peptidase S41A family
DPM16_RS07555	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DPM16_RS07560	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DPM16_RS07570	COG0189	ligase activity
DPM16_RS07580	COG0004	ammonium transporteR
DPM16_RS07595	COG2960	long-chain fatty acid transporting porin activity
DPM16_RS07605	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DPM16_RS07610	COG0321	lipoyl(octanoyl) transferase activity
DPM16_RS07635	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
DPM16_RS07635	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
DPM16_RS07640	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
DPM16_RS07645	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DPM16_RS07650	COG0386	Belongs to the glutathione peroxidase family
DPM16_RS07670	COG0300	oxidoreductase activity
DPM16_RS07675	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DPM16_RS07685	COG0018	arginyl-trna synthetase
DPM16_RS07695	COG1410	methionine synthase
DPM16_RS07695	COG0646	methionine synthase
DPM16_RS07700	COG1410	methionine synthase
DPM16_RS07700	COG0646	methionine synthase
DPM16_RS07710	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DPM16_RS07720	COG0604	alcohol dehydrogenase
DPM16_RS07730	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DPM16_RS07735	COG0625	glutathione transferase activity
DPM16_RS07740	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DPM16_RS07745	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DPM16_RS07750	COG0037	tRNA processing
DPM16_RS07760	COG1028	Short-chain dehydrogenase reductase Sdr
DPM16_RS07795	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
DPM16_RS07800	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DPM16_RS07815	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DPM16_RS07820	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DPM16_RS07825	COG0708	Exodeoxyribonuclease III
DPM16_RS07830	COG2814	Major facilitator Superfamily
DPM16_RS07840	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DPM16_RS07850	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DPM16_RS07860	COG0523	cobalamin synthesis protein
DPM16_RS07865	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
DPM16_RS07875	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DPM16_RS07880	COG0154	amidase activity
DPM16_RS07885	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DPM16_RS07890	COG1077	Cell shape determining protein MreB Mrl
DPM16_RS07905	COG0768	penicillin binding
DPM16_RS07910	COG0772	Belongs to the SEDS family
DPM16_RS07930	COG1872	DUF167
DPM16_RS07935	COG0288	reversible hydration of carbon dioxide
DPM16_RS07955	COG1301	dicarboxylic acid transport
DPM16_RS07960	COG1187	pseudouridine synthase activity
DPM16_RS07965	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
DPM16_RS07980	COG3713	MltA-interacting MipA family protein
DPM16_RS08010	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DPM16_RS08015	COG1305	Transglutaminase-like
DPM16_RS08020	COG1942	4-Oxalocrotonate Tautomerase
DPM16_RS08115	COG1944	ATP diphosphatase activity
DPM16_RS08120	COG2204	response regulator
DPM16_RS08125	COG5000	phosphorelay sensor kinase activity
DPM16_RS08135	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DPM16_RS08135	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DPM16_RS08140	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DPM16_RS08145	COG0242	peptide deformylase activity
DPM16_RS08150	COG0758	DNA mediated transformation
DPM16_RS08165	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
DPM16_RS08170	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DPM16_RS08175	COG0706	membrane insertase activity
DPM16_RS08180	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DPM16_RS08185	COG0594	ribonuclease P activity
DPM16_RS08190	COG0230	Belongs to the bacterial ribosomal protein bL34 family