locus-tag	class	description
C3B54_RS00005	COG4948	Mandelate Racemase Muconate Lactonizing
C3B54_RS00010	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C3B54_RS00020	COG0785	Cytochrome C biogenesis protein
C3B54_RS00025	COG3118	belongs to the thioredoxin family
C3B54_RS00035	COG0730	response to heat
C3B54_RS00040	COG0175	sulfate reduction
C3B54_RS00045	COG0529	Catalyzes the synthesis of activated sulfate
C3B54_RS00045	COG2895	sulfate adenylyltransferase (ATP) activity
C3B54_RS00060	COG2030	dehydratase
C3B54_RS00070	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C3B54_RS00075	COG0436	Aminotransferase
C3B54_RS00080	COG0017	Asparaginyl-tRNA synthetase
C3B54_RS00140	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
C3B54_RS00155	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C3B54_RS00180	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C3B54_RS00180	COG2755	lipolytic protein G-D-S-L family
C3B54_RS00185	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C3B54_RS00190	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C3B54_RS00215	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C3B54_RS00235	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C3B54_RS00240	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
C3B54_RS00245	COG0037	tRNA processing
C3B54_RS00250	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C3B54_RS00255	COG1196	nuclear chromosome segregation
C3B54_RS00255	COG0741	lytic transglycosylase activity
C3B54_RS00255	COG0739	heme binding
C3B54_RS00310	COG2197	response regulator
C3B54_RS00355	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C3B54_RS00360	COG0204	Acyl-transferase
C3B54_RS00360	COG0318	PFAM AMP-dependent synthetase and ligase
C3B54_RS00365	COG1045	serine acetyltransferase
C3B54_RS00380	COG2364	Membrane
C3B54_RS00390	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C3B54_RS00405	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C3B54_RS00430	COG0151	Belongs to the GarS family
C3B54_RS00435	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C3B54_RS00450	COG0047	phosphoribosylformylglycinamidine synthase activity
C3B54_RS00460	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C3B54_RS00470	COG1605	Chorismate mutase
C3B54_RS00470	COG0287	Prephenate dehydrogenase
C3B54_RS00475	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C3B54_RS00490	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C3B54_RS00515	COG0542	response to heat
C3B54_RS00520	COG0789	Transcriptional regulator
C3B54_RS00525	COG0484	heat shock protein binding
C3B54_RS00530	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C3B54_RS00535	COG0443	Heat shock 70 kDa protein
C3B54_RS00570	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
C3B54_RS00575	COG0717	Belongs to the dCTP deaminase family
C3B54_RS00585	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C3B54_RS00605	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
C3B54_RS00630	COG0456	acetyltransferase
C3B54_RS00655	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C3B54_RS00660	COG0187	DNA topoisomerase II activity
C3B54_RS00665	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
C3B54_RS00670	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C3B54_RS00675	COG0592	DNA-directed DNA polymerase activity
C3B54_RS00680	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C3B54_RS00685	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C3B54_RS00690	COG0594	ribonuclease P activity
C3B54_RS00695	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C3B54_RS00700	COG0706	membrane insertase activity
C3B54_RS00710	COG0357	Ribosomal RNA small subunit methyltransferase G
C3B54_RS00715	COG1192	Involved in chromosome partitioning
C3B54_RS00725	COG1181	Belongs to the D-alanine--D-alanine ligase family
C3B54_RS00730	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C3B54_RS00735	COG3118	belongs to the thioredoxin family
C3B54_RS00740	COG0492	ferredoxin-NADP+ reductase activity
C3B54_RS00755	COG0617	tRNA 3'-terminal CCA addition
C3B54_RS00760	COG0360	Binds together with S18 to 16S ribosomal RNA
C3B54_RS00765	COG0629	single-stranded DNA binding
C3B54_RS00770	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C3B54_RS00775	COG0359	binds to the 23S rRNA
C3B54_RS00780	COG0305	Participates in initiation and elongation during chromosome replication
C3B54_RS00795	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
C3B54_RS00805	COG2877	3-deoxy-8-phosphooctulonate synthase activity
C3B54_RS00810	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
C3B54_RS00845	COG0745	RESPONSE REGULATOR receiver
C3B54_RS00850	COG2205	protein histidine kinase activity
C3B54_RS00875	COG0022	dehydrogenase e1 component
C3B54_RS00880	COG0508	dehydrogenase complex catalyzes the overall conversion of
C3B54_RS00885	COG0803	Belongs to the bacterial solute-binding protein 9 family
C3B54_RS00895	COG1121	(ABC) transporter
C3B54_RS00905	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C3B54_RS00910	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C3B54_RS00915	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C3B54_RS00920	COG0776	regulation of translation
C3B54_RS00940	COG0705	Rhomboid family
C3B54_RS00960	COG0515	serine threonine protein kinase
C3B54_RS00960	COG2815	serine threonine protein kinase
C3B54_RS00965	COG0515	serine threonine protein kinase
C3B54_RS00970	COG0768	penicillin binding
C3B54_RS01000	COG3177	Filamentation induced by cAMP protein fic
C3B54_RS01005	COG1012	belongs to the aldehyde dehydrogenase family
C3B54_RS01010	COG2608	mercury ion transmembrane transporter activity
C3B54_RS01025	COG0546	phosphoglycolate phosphatase activity
C3B54_RS01030	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
C3B54_RS01035	COG0738	Major facilitator superfamily
C3B54_RS01040	COG0534	Mate efflux family protein
C3B54_RS01045	COG3590	peptidase
C3B54_RS01090	COG1834	amidinotransferase
C3B54_RS01095	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C3B54_RS01110	COG3842	ATPase activity
C3B54_RS01120	COG2267	carboxylic ester hydrolase activity
C3B54_RS01130	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C3B54_RS01135	COG1120	ATPase activity
C3B54_RS01150	COG0077	Prephenate dehydratase
C3B54_RS01155	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C3B54_RS01160	COG0561	phosphatase activity
C3B54_RS01170	COG1316	TRANSCRIPTIONal
C3B54_RS01210	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C3B54_RS01215	COG2133	pyrroloquinoline quinone binding
C3B54_RS01275	COG0659	secondary active sulfate transmembrane transporter activity
C3B54_RS01285	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
C3B54_RS01305	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
C3B54_RS01325	COG1174	glycine betaine transport
C3B54_RS01355	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C3B54_RS01370	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C3B54_RS01375	COG0573	inorganic phosphate transmembrane transporter activity
C3B54_RS01380	COG0573	inorganic phosphate transmembrane transporter activity
C3B54_RS01385	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C3B54_RS01400	COG2313	pseudouridylate synthase activity
C3B54_RS01410	COG0415	Belongs to the DNA photolyase family
C3B54_RS01415	COG0745	RESPONSE REGULATOR receiver
C3B54_RS01420	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C3B54_RS01445	COG0569	domain protein
C3B54_RS01450	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C3B54_RS01455	COG0640	Transcriptional regulator
C3B54_RS01500	COG0085	RNA polymerase activity
C3B54_RS01505	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C3B54_RS01515	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C3B54_RS01520	COG0049	tRNA binding
C3B54_RS01525	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C3B54_RS01530	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C3B54_RS01535	COG1476	TRANSCRIPTIONal
C3B54_RS01555	COG0051	transcription antitermination factor activity, RNA binding
C3B54_RS01560	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C3B54_RS01565	COG0088	Forms part of the polypeptide exit tunnel
C3B54_RS01570	COG0089	rRNA binding
C3B54_RS01575	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C3B54_RS01580	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C3B54_RS01585	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C3B54_RS01590	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C3B54_RS01595	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C3B54_RS01600	COG0255	Belongs to the universal ribosomal protein uL29 family
C3B54_RS01605	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C3B54_RS01610	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C3B54_RS01615	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C3B54_RS01620	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C3B54_RS01625	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C3B54_RS01630	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C3B54_RS01635	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C3B54_RS01640	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C3B54_RS01645	COG1841	ribosomal large subunit assembly
C3B54_RS01650	COG0200	Binds to the 23S rRNA
C3B54_RS01660	COG0563	adenylate kinase activity
C3B54_RS01665	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C3B54_RS01670	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C3B54_RS01675	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C3B54_RS01680	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C3B54_RS01685	COG0202	RNA polymerase activity
C3B54_RS01690	COG0203	ribosomal protein L17
C3B54_RS01695	COG0101	tRNA pseudouridine synthase activity
C3B54_RS01700	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C3B54_RS01705	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C3B54_RS01710	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C3B54_RS01715	COG1072	(Pantothenic acid kinase))
C3B54_RS01720	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C3B54_RS01725	COG0736	holo-[acyl-carrier-protein] synthase activity
C3B54_RS01730	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C3B54_RS01735	COG0802	atpase or kinase
C3B54_RS01745	COG0456	acetyltransferase
C3B54_RS01750	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C3B54_RS01760	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C3B54_RS01800	COG0516	GMP reductase activity
C3B54_RS01815	COG0519	Catalyzes the synthesis of GMP from XMP
C3B54_RS01815	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C3B54_RS01835	COG0045	succinate-CoA ligase (ADP-forming) activity
C3B54_RS01850	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C3B54_RS01855	COG0138	bifunctional purine biosynthesis protein purh
C3B54_RS01865	COG0538	isocitrate dehydrogenase activity
C3B54_RS01900	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C3B54_RS01905	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C3B54_RS01920	COG1408	metallophosphoesterase
C3B54_RS01925	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C3B54_RS01935	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C3B54_RS01965	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C3B54_RS01965	COG1754	DNA topoisomerase type I activity
C3B54_RS01970	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C3B54_RS02020	COG2111	Na H antiporter
C3B54_RS02020	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C3B54_RS02025	COG1006	Multisubunit Na H antiporter MnhC subunit
C3B54_RS02030	COG0651	ATP synthesis coupled electron transport
C3B54_RS02045	COG1320	monovalent cation:proton antiporter activity
C3B54_RS02050	COG2217	Heavy metal translocating P-type atpase
C3B54_RS02070	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C3B54_RS02105	COG0459	protein refolding
C3B54_RS02110	COG2205	protein histidine kinase activity
C3B54_RS02115	COG0745	RESPONSE REGULATOR receiver
C3B54_RS02140	COG1477	protein flavinylation
C3B54_RS02155	COG2205	protein histidine kinase activity
C3B54_RS02160	COG0745	RESPONSE REGULATOR receiver
C3B54_RS02190	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C3B54_RS02205	COG1819	glycosyl
C3B54_RS02230	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C3B54_RS02250	COG1755	Isoprenylcysteine carboxyl methyltransferase
C3B54_RS02255	COG0644	oxidoreductase
C3B54_RS02295	COG2801	Transposase and inactivated derivatives
C3B54_RS02295	COG3415	Transposase
C3B54_RS02305	COG0640	Transcriptional regulator
C3B54_RS02340	COG2188	Transcriptional regulator
C3B54_RS02360	COG4821	SIS domain
C3B54_RS02365	COG1070	Carbohydrate kinase
C3B54_RS02375	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C3B54_RS02390	COG3549	Plasmid maintenance system killer
C3B54_RS02400	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
C3B54_RS02410	COG3152	Membrane
C3B54_RS02415	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
C3B54_RS02440	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C3B54_RS02440	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C3B54_RS02465	COG1331	Highly conserved protein containing a thioredoxin domain
C3B54_RS02470	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C3B54_RS02475	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C3B54_RS02480	COG0084	hydrolase, TatD family'
C3B54_RS02485	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C3B54_RS02495	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C3B54_RS02500	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C3B54_RS02505	COG0488	(ABC) transporter
C3B54_RS02510	COG1846	Transcriptional regulator
C3B54_RS02520	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C3B54_RS02525	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C3B54_RS02540	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
C3B54_RS02545	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C3B54_RS02550	COG0193	aminoacyl-tRNA hydrolase activity
C3B54_RS02565	COG0124	histidyl-tRNA synthetase
C3B54_RS02570	COG0148	phosphopyruvate hydratase activity
C3B54_RS02600	COG1704	LemA family
C3B54_RS02605	COG0501	Belongs to the peptidase M48B family
C3B54_RS02615	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C3B54_RS02620	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C3B54_RS02635	COG1272	protein, Hemolysin III
C3B54_RS02640	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C3B54_RS02645	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C3B54_RS02650	COG0114	fumarate hydratase activity
C3B54_RS02660	COG1722	exodeoxyribonuclease VII activity
C3B54_RS02665	COG1570	exodeoxyribonuclease VII activity
C3B54_RS02670	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C3B54_RS02680	COG1494	fructose-1,6-bisphosphatase
C3B54_RS02685	COG1322	Protein conserved in bacteria
C3B54_RS02690	COG0012	GTP binding
C3B54_RS02730	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C3B54_RS02735	COG0509	glycine decarboxylation via glycine cleavage system
C3B54_RS02740	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C3B54_RS02740	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C3B54_RS02790	COG0179	Fumarylacetoacetate (FAA) hydrolase
C3B54_RS02795	COG0477	Major facilitator Superfamily
C3B54_RS02800	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C3B54_RS02810	COG1929	Belongs to the glycerate kinase type-1 family
C3B54_RS02825	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C3B54_RS02830	COG0066	3-isopropylmalate dehydratase activity
C3B54_RS02835	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C3B54_RS02845	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C3B54_RS02850	COG0596	Alpha beta hydrolase
C3B54_RS02855	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C3B54_RS02860	COG1181	Belongs to the D-alanine--D-alanine ligase family
C3B54_RS02875	COG0742	ribosomal rna small subunit methyltransferase
C3B54_RS02880	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C3B54_RS02885	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C3B54_RS02895	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C3B54_RS02900	COG0571	ribonuclease III activity
C3B54_RS02905	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C3B54_RS02910	COG1196	nuclear chromosome segregation
C3B54_RS02930	COG0228	four-way junction DNA binding
C3B54_RS02935	COG1837	Belongs to the UPF0109 family
C3B54_RS02940	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C3B54_RS02945	COG0336	Belongs to the RNA methyltransferase TrmD family
C3B54_RS02950	COG0024	Methionine aminopeptidase
C3B54_RS02960	COG0335	large ribosomal subunit rRNA binding
C3B54_RS02965	COG0681	Belongs to the peptidase S26 family
C3B54_RS02970	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C3B54_RS02990	COG4974	Belongs to the 'phage' integrase family
C3B54_RS03000	COG0052	Belongs to the universal ribosomal protein uS2 family
C3B54_RS03005	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C3B54_RS03010	COG0528	UMP kinase activity
C3B54_RS03015	COG0233	cytoplasmic translational termination
C3B54_RS03020	COG0575	Belongs to the CDS family
C3B54_RS03065	COG0482	sulfurtransferase activity
C3B54_RS03070	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C3B54_RS03075	COG0750	zinc metalloprotease
C3B54_RS03080	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C3B54_RS03085	COG0442	prolyl-tRNA aminoacylation
C3B54_RS03090	COG0195	Participates in both transcription termination and antitermination
C3B54_RS03100	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C3B54_RS03105	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C3B54_RS03110	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
C3B54_RS03115	COG1194	a g-specific adenine glycosylase
C3B54_RS03120	COG0702	epimerase
C3B54_RS03125	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C3B54_RS03160	COG1027	Aspartate ammonia-lyase
C3B54_RS03175	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C3B54_RS03180	COG1185	polyribonucleotide nucleotidyltransferase activity
C3B54_RS03190	COG0612	Peptidase, M16
C3B54_RS03200	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C3B54_RS03205	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C3B54_RS03210	COG0154	amidase activity
C3B54_RS03215	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C3B54_RS03230	COG1278	Cold shock
C3B54_RS03245	COG0463	Glycosyl transferase, family 2
C3B54_RS03275	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
C3B54_RS03290	COG1136	(ABC) transporter
C3B54_RS03290	COG0577	efflux transmembrane transporter activity
C3B54_RS03295	COG0577	efflux transmembrane transporter activity
C3B54_RS03300	COG3654	unkown
C3B54_RS03315	COG4948	Mandelate Racemase Muconate Lactonizing
C3B54_RS03350	COG1349	DNA-binding transcription factor activity
C3B54_RS03355	COG4213	ABC transporter substrate-binding protein
C3B54_RS03365	COG4214	carbohydrate transport
C3B54_RS03370	COG1253	flavin adenine dinucleotide binding
C3B54_RS03385	COG0385	Bile acid
C3B54_RS03400	COG0697	spore germination
C3B54_RS03415	COG0659	secondary active sulfate transmembrane transporter activity
C3B54_RS03450	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C3B54_RS03455	COG0483	inositol monophosphate 1-phosphatase activity
C3B54_RS03460	COG0438	transferase activity, transferring glycosyl groups
C3B54_RS03510	COG1733	regulation of RNA biosynthetic process
C3B54_RS03575	COG2837	iron assimilation
C3B54_RS03580	COG0667	Aldo Keto reductase
C3B54_RS03595	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C3B54_RS03600	COG0629	single-stranded DNA binding
C3B54_RS03625	COG0668	transmembrane transport
C3B54_RS03640	COG0698	ribose 5-phosphate isomerase
C3B54_RS03675	COG0544	peptidyl-prolyl cis-trans isomerase activity
C3B54_RS03680	COG0740	serine-type endopeptidase activity
C3B54_RS03685	COG0740	serine-type endopeptidase activity
C3B54_RS03695	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C3B54_RS03710	COG0525	valine-tRNA ligase activity
C3B54_RS03720	COG0747	negative chemotaxis
C3B54_RS03730	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C3B54_RS03740	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C3B54_RS03745	COG0285	dihydrofolate synthase activity
C3B54_RS03765	COG1530	ribonuclease E activity
C3B54_RS03770	COG0701	Predicted permease
C3B54_RS03785	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C3B54_RS03790	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C3B54_RS03795	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C3B54_RS03800	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C3B54_RS03805	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C3B54_RS03815	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C3B54_RS03825	COG0799	negative regulation of ribosome biogenesis
C3B54_RS03835	COG0259	pyridoxamine-phosphate oxidase activity
C3B54_RS03840	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C3B54_RS03850	COG4651	solute:proton antiporter activity
C3B54_RS03850	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C3B54_RS03855	COG1472	Belongs to the glycosyl hydrolase 3 family
C3B54_RS03870	COG1125	glycine betaine transport
C3B54_RS03870	COG0517	IMP dehydrogenase activity
C3B54_RS03880	COG1174	glycine betaine transport
C3B54_RS03885	COG1732	Glycine betaine
C3B54_RS03890	COG0586	Pfam SNARE associated Golgi protein
C3B54_RS03895	COG1271	oxidase subunit
C3B54_RS03900	COG1294	oxidase, subunit
C3B54_RS03905	COG4988	ABC transporter
C3B54_RS03910	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C3B54_RS03920	COG0512	Glutamine amidotransferase of anthranilate synthase
C3B54_RS03920	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C3B54_RS03925	COG0495	leucyl-tRNA aminoacylation
C3B54_RS03930	COG1596	polysaccharide export
C3B54_RS03930	COG1555	photosystem II stabilization
C3B54_RS03945	COG0268	Binds directly to 16S ribosomal RNA
C3B54_RS03950	COG0481	GTPase activity
C3B54_RS03960	COG0196	riboflavin kinase activity
C3B54_RS03970	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C3B54_RS03975	COG1012	belongs to the aldehyde dehydrogenase family
C3B54_RS03980	COG1012	belongs to the aldehyde dehydrogenase family
C3B54_RS03985	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C3B54_RS04000	COG1420	regulation of RNA biosynthetic process
C3B54_RS04005	COG0484	heat shock protein binding
C3B54_RS04015	COG0537	adenosine 5'-monophosphoramidase activity
C3B54_RS04025	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C3B54_RS04035	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C3B54_RS04040	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C3B54_RS04045	COG1381	Involved in DNA repair and RecF pathway recombination
C3B54_RS04050	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C3B54_RS04055	COG0423	glycine-tRNA ligase activity
C3B54_RS04105	COG1064	alcohol dehydrogenase
C3B54_RS04130	COG1609	Transcriptional regulator
C3B54_RS04135	COG2084	Dehydrogenase
C3B54_RS04145	COG0601	transmembrane transport
C3B54_RS04150	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C3B54_RS04155	COG0444	Belongs to the ABC transporter superfamily
C3B54_RS04160	COG4608	Belongs to the ABC transporter superfamily
C3B54_RS04170	COG1217	gtp-binding protein TYPA
C3B54_RS04175	COG1028	Short-chain dehydrogenase reductase Sdr
C3B54_RS04180	COG1126	abc transporter atp-binding protein
C3B54_RS04185	COG0765	amino acid transport
C3B54_RS04190	COG4597	amino acid ABC transporter
C3B54_RS04195	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C3B54_RS04220	COG2197	response regulator
C3B54_RS04265	COG1309	transcriptional regulator
C3B54_RS04270	COG0387	Pfam Sodium calcium exchanger
C3B54_RS04290	COG1132	(ABC) transporter
C3B54_RS04295	COG1132	(ABC) transporter
C3B54_RS04300	COG0513	Belongs to the DEAD box helicase family
C3B54_RS04315	COG1309	transcriptional regulator
C3B54_RS04330	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C3B54_RS04345	COG0181	hydroxymethylbilane synthase activity
C3B54_RS04350	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C3B54_RS04355	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C3B54_RS04365	COG3253	May function as heme-dependent peroxidase
C3B54_RS04370	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C3B54_RS04425	COG2409	Drug exporters of the RND superfamily
C3B54_RS04440	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C3B54_RS04445	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C3B54_RS04450	COG3321	synthase
C3B54_RS04450	COG0604	alcohol dehydrogenase
C3B54_RS04460	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C3B54_RS04525	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C3B54_RS04530	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C3B54_RS04530	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C3B54_RS04540	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C3B54_RS04545	COG0174	glutamine synthetase
C3B54_RS04560	COG0508	dehydrogenase complex catalyzes the overall conversion of
C3B54_RS04565	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C3B54_RS04570	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C3B54_RS04580	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C3B54_RS04585	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C3B54_RS04595	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C3B54_RS04600	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C3B54_RS04610	COG0187	DNA topoisomerase II activity
C3B54_RS04615	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C3B54_RS04655	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C3B54_RS04660	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C3B54_RS04690	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C3B54_RS04720	COG1716	ATPase activity
C3B54_RS04735	COG1192	Involved in chromosome partitioning
C3B54_RS04740	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
C3B54_RS04755	COG1940	carbohydrate kinase activity
C3B54_RS04765	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
C3B54_RS04770	COG0515	serine threonine protein kinase
C3B54_RS04770	COG2815	serine threonine protein kinase
C3B54_RS04775	COG3942	CHAP domain
C3B54_RS04775	COG1388	LysM domain
C3B54_RS04785	COG0142	geranyltranstransferase activity
C3B54_RS04795	COG2001	Belongs to the MraZ family
C3B54_RS04800	COG0275	rRNA processing
C3B54_RS04810	COG0768	penicillin binding
C3B54_RS04815	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C3B54_RS04825	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C3B54_RS04830	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C3B54_RS04840	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C3B54_RS04845	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C3B54_RS04855	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C3B54_RS04865	COG1799	cell septum assembly
C3B54_RS04895	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C3B54_RS04900	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C3B54_RS04905	COG0167	dihydroorotate dehydrogenase activity
C3B54_RS04915	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C3B54_RS04925	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C3B54_RS04930	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C3B54_RS04945	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
C3B54_RS04950	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C3B54_RS04955	COG0723	plastoquinol--plastocyanin reductase activity
C3B54_RS04960	COG2010	Cytochrome c
C3B54_RS04965	COG1845	cytochrome c oxidase, subunit III
C3B54_RS04970	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C3B54_RS04990	COG1051	belongs to the nudix hydrolase family
C3B54_RS05015	COG0805	protein transport
C3B54_RS05020	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C3B54_RS05030	COG2378	regulation of single-species biofilm formation
C3B54_RS05045	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C3B54_RS05055	COG1968	undecaprenyl-diphosphatase activity
C3B54_RS05075	COG0587	DNA-directed DNA polymerase activity
C3B54_RS05090	COG0588	phosphoglycerate mutase activity
C3B54_RS05095	COG0442	prolyl-tRNA aminoacylation
C3B54_RS05100	COG0366	Alpha amylase catalytic
C3B54_RS05110	COG0254	rRNA binding
C3B54_RS05115	COG1119	ATPase activity
C3B54_RS05120	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C3B54_RS05150	COG2151	metal-sulfur cluster biosynthetic enzyme
C3B54_RS05155	COG0396	ATPase activity
C3B54_RS05165	COG0719	Fe-S assembly protein
C3B54_RS05180	COG0109	protoheme IX farnesyltransferase activity
C3B54_RS05190	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C3B54_RS05195	COG0166	Belongs to the GPI family
C3B54_RS05220	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C3B54_RS05225	COG0149	triose-phosphate isomerase activity
C3B54_RS05230	COG0126	phosphoglycerate kinase activity
C3B54_RS05235	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C3B54_RS05245	COG1481	regulation of sporulation
C3B54_RS05250	COG1660	Displays ATPase and GTPase activities
C3B54_RS05255	COG0322	excinuclease ABC activity
C3B54_RS05265	COG0556	nucleotide-excision repair
C3B54_RS05270	COG0237	dephospho-CoA kinase activity
C3B54_RS05275	COG0539	negative regulation of cytoplasmic translation
C3B54_RS05285	COG2050	protein possibly involved in aromatic compounds catabolism
C3B54_RS05305	COG0469	pyruvate kinase activity
C3B54_RS05315	COG0067	glutamate synthase
C3B54_RS05315	COG0069	glutamate synthase activity
C3B54_RS05315	COG0070	glutamate synthase
C3B54_RS05320	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C3B54_RS05325	COG0159	tryptophan synthase activity
C3B54_RS05330	COG0133	tryptophan synthase activity
C3B54_RS05335	COG0134	indole-3-glycerol-phosphate synthase activity
C3B54_RS05355	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C3B54_RS05360	COG0107	imidazoleglycerol-phosphate synthase activity
C3B54_RS05365	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C3B54_RS05370	COG0140	phosphoribosyl-ATP diphosphatase activity
C3B54_RS05375	COG0545	Peptidyl-prolyl cis-trans isomerase
C3B54_RS05390	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C3B54_RS05395	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C3B54_RS05400	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C3B54_RS05410	COG1758	RNA polymerase activity
C3B54_RS05415	COG0194	GDP metabolic process
C3B54_RS05420	COG0284	orotidine-5'-phosphate decarboxylase activity
C3B54_RS05425	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C3B54_RS05430	COG0505	Belongs to the CarA family
C3B54_RS05440	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C3B54_RS05445	COG0540	Belongs to the ATCase OTCase family
C3B54_RS05450	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C3B54_RS05455	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C3B54_RS05460	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C3B54_RS05465	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C3B54_RS05470	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C3B54_RS05480	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C3B54_RS05485	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C3B54_RS05495	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C3B54_RS05500	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C3B54_RS05505	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C3B54_RS05530	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C3B54_RS05535	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C3B54_RS05545	COG1862	Preprotein translocase
C3B54_RS05550	COG2255	four-way junction helicase activity
C3B54_RS05555	COG0632	four-way junction helicase activity
C3B54_RS05560	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C3B54_RS05565	COG0217	transcriptional regulatory protein
C3B54_RS05570	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
C3B54_RS05575	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
C3B54_RS05585	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C3B54_RS05625	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C3B54_RS05635	COG1063	alcohol dehydrogenase
C3B54_RS05645	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C3B54_RS05645	COG2213	PTS system mannitol-specific
C3B54_RS05655	COG1349	DNA-binding transcription factor activity
C3B54_RS05660	COG1105	Belongs to the carbohydrate kinase PfkB family
C3B54_RS05670	COG0277	FAD linked oxidase domain protein
C3B54_RS05695	COG0039	L-malate dehydrogenase activity
C3B54_RS05705	COG1609	Transcriptional regulator
C3B54_RS05745	COG4214	carbohydrate transport
C3B54_RS05750	COG0673	inositol 2-dehydrogenase activity
C3B54_RS05760	COG2271	Major facilitator Superfamily
C3B54_RS05770	COG1160	GTP binding
C3B54_RS05775	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C3B54_RS05785	COG1187	pseudouridine synthase activity
C3B54_RS05790	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C3B54_RS05805	COG4974	Belongs to the 'phage' integrase family
C3B54_RS05815	COG0504	CTP synthase activity
C3B54_RS05820	COG0497	DNA recombination
C3B54_RS05825	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C3B54_RS05840	COG0647	UMP catabolic process
C3B54_RS05865	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C3B54_RS05875	COG0765	amino acid transport
C3B54_RS05900	COG0165	Argininosuccinate lyase
C3B54_RS05905	COG0137	argininosuccinate synthase activity
C3B54_RS05910	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C3B54_RS05915	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C3B54_RS05920	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C3B54_RS05925	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C3B54_RS05930	COG0072	phenylalanine-tRNA ligase activity
C3B54_RS05930	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C3B54_RS05935	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C3B54_RS05940	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C3B54_RS05945	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C3B54_RS05950	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C3B54_RS05955	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C3B54_RS05980	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C3B54_RS05985	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C3B54_RS05990	COG0131	Imidazoleglycerol-phosphate dehydratase
C3B54_RS05995	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C3B54_RS06005	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C3B54_RS06015	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C3B54_RS06045	COG1848	Toxic component of a toxin-antitoxin (TA) module. An RNase
C3B54_RS06060	COG2337	Toxic component of a toxin-antitoxin (TA) module
C3B54_RS06115	COG1012	belongs to the aldehyde dehydrogenase family
C3B54_RS06120	COG3842	ATPase activity
C3B54_RS06125	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C3B54_RS06130	COG1176	ABC-type spermidine putrescine transport system, permease component I
C3B54_RS06135	COG1177	transmembrane transport
C3B54_RS06150	COG1070	Carbohydrate kinase
C3B54_RS06155	COG0434	BtpA family
C3B54_RS06160	COG2084	Dehydrogenase
C3B54_RS06165	COG1461	Dihydroxyacetone kinase
C3B54_RS06170	COG2376	Dihydroxyacetone kinase
C3B54_RS06180	COG1172	Belongs to the binding-protein-dependent transport system permease family
C3B54_RS06185	COG1129	ABC transporter
C3B54_RS06195	COG1349	DNA-binding transcription factor activity
C3B54_RS06200	COG1069	ribulokinase activity
C3B54_RS06210	COG1063	alcohol dehydrogenase
C3B54_RS06215	COG1830	Aldolase
C3B54_RS06250	COG0747	negative chemotaxis
C3B54_RS06255	COG1024	Enoyl-CoA hydratase
C3B54_RS06260	COG4608	Belongs to the ABC transporter superfamily
C3B54_RS06270	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C3B54_RS06275	COG1012	belongs to the aldehyde dehydrogenase family
C3B54_RS06280	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C3B54_RS06285	COG1028	Short-chain dehydrogenase reductase Sdr
C3B54_RS06290	COG0473	3-isopropylmalate dehydrogenase activity
C3B54_RS06310	COG1609	Transcriptional regulator
C3B54_RS06320	COG4948	Mandelate Racemase Muconate Lactonizing
C3B54_RS06325	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C3B54_RS06340	COG4948	Mandelate Racemase Muconate Lactonizing
C3B54_RS06400	COG2801	Transposase and inactivated derivatives
C3B54_RS06455	COG0732	type I restriction modification DNA specificity domain
C3B54_RS06470	COG2314	TM2 domain
C3B54_RS06485	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C3B54_RS06490	COG1957	nucleoside hydrolase
C3B54_RS06505	COG1172	Belongs to the binding-protein-dependent transport system permease family
C3B54_RS06515	COG1879	ABC-type sugar transport system periplasmic component
C3B54_RS06535	COG1414	Transcriptional regulator
C3B54_RS06540	COG0183	Belongs to the thiolase family
C3B54_RS06545	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C3B54_RS06575	COG3284	Transcriptional regulator
C3B54_RS06580	COG1172	Belongs to the binding-protein-dependent transport system permease family
C3B54_RS06585	COG1129	ABC transporter
C3B54_RS06610	COG2072	flavoprotein involved in K transport
C3B54_RS06615	COG1028	Short-chain dehydrogenase reductase Sdr
C3B54_RS06630	COG0667	Aldo Keto reductase
C3B54_RS06640	COG0129	dihydroxy-acid dehydratase activity
C3B54_RS06645	COG0179	Fumarylacetoacetate (FAA) hydrolase
C3B54_RS06680	COG4948	Mandelate Racemase Muconate Lactonizing
C3B54_RS06685	COG1028	Short-chain dehydrogenase reductase Sdr
C3B54_RS06690	COG1129	ABC transporter
C3B54_RS06700	COG4214	carbohydrate transport
C3B54_RS06705	COG4948	Mandelate Racemase Muconate Lactonizing
C3B54_RS06720	COG1802	Transcriptional regulator
C3B54_RS06725	COG2337	Toxic component of a toxin-antitoxin (TA) module
C3B54_RS06745	COG4691	Plasmid stability protein
C3B54_RS06750	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
C3B54_RS06750	COG0778	Nitroreductase
C3B54_RS06770	COG2813	Specifically methylates the guanine in position
C3B54_RS06775	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C3B54_RS06780	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C3B54_RS06785	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C3B54_RS06790	COG2137	regulation of response to DNA damage stimulus
C3B54_RS06795	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C3B54_RS06810	COG1546	Belongs to the CinA family
C3B54_RS06810	COG1058	Belongs to the CinA family
C3B54_RS06820	COG1674	ftsk spoiiie
C3B54_RS06825	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
C3B54_RS06830	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C3B54_RS06835	COG2197	response regulator
C3B54_RS06840	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
C3B54_RS06855	COG1764	response to oxidative stress
C3B54_RS06860	COG1090	epimerase
C3B54_RS06880	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C3B54_RS06895	COG1937	Protein conserved in bacteria
C3B54_RS06900	COG0446	pyridine nucleotide-disulphide oxidoreductase
C3B54_RS06910	COG0545	Peptidyl-prolyl cis-trans isomerase
C3B54_RS06960	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C3B54_RS06965	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C3B54_RS06975	COG3022	response to hydroperoxide
C3B54_RS06980	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C3B54_RS06985	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C3B54_RS06990	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C3B54_RS06995	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C3B54_RS07000	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C3B54_RS07005	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C3B54_RS07010	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C3B54_RS07015	COG0356	it plays a direct role in the translocation of protons across the membrane
C3B54_RS07030	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C3B54_RS07035	COG0009	L-threonylcarbamoyladenylate synthase
C3B54_RS07050	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C3B54_RS07060	COG0083	homoserine kinase activity
C3B54_RS07065	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C3B54_RS07070	COG0460	homoserine dehydrogenase
C3B54_RS07080	COG0018	arginyl-trna synthetase
C3B54_RS07095	COG1569	PIN domain
C3B54_RS07100	COG3311	Transcriptional regulator
C3B54_RS07110	COG2197	response regulator
C3B54_RS07115	COG1396	sequence-specific DNA binding
C3B54_RS07120	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
C3B54_RS07145	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C3B54_RS07160	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C3B54_RS07180	COG0567	Dehydrogenase, E1 component
C3B54_RS07180	COG0508	dehydrogenase complex catalyzes the overall conversion of
C3B54_RS07190	COG1595	DNA-templated transcription, initiation
C3B54_RS07195	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C3B54_RS07205	COG0483	inositol monophosphate 1-phosphatase activity
C3B54_RS07230	COG0395	ABC-type sugar transport system, permease component
C3B54_RS07235	COG1175	transmembrane transport
C3B54_RS07240	COG1653	transport
C3B54_RS07250	COG0477	Major facilitator Superfamily
C3B54_RS07255	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C3B54_RS07260	COG2177	Part of the ABC transporter FtsEX involved in
C3B54_RS07265	COG2884	Cell division ATP-binding protein ftsE
C3B54_RS07270	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
C3B54_RS07320	COG1028	Short-chain dehydrogenase reductase Sdr
C3B54_RS07325	COG0508	dehydrogenase complex catalyzes the overall conversion of
C3B54_RS07330	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C3B54_RS07340	COG1802	Transcriptional regulator
C3B54_RS07345	COG1012	belongs to the aldehyde dehydrogenase family
C3B54_RS07350	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C3B54_RS07365	COG1879	ABC-type sugar transport system periplasmic component
C3B54_RS07370	COG1172	Belongs to the binding-protein-dependent transport system permease family
C3B54_RS07375	COG1172	Belongs to the binding-protein-dependent transport system permease family
C3B54_RS07380	COG1129	ABC transporter
C3B54_RS07415	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C3B54_RS07420	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C3B54_RS07425	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C3B54_RS07430	COG1365	unkown
C3B54_RS07435	COG3046	protein related to deoxyribodipyrimidine photolyase
C3B54_RS07450	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C3B54_RS07470	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C3B54_RS07475	COG3842	ATPase activity
C3B54_RS07480	COG3842	ATPase activity
C3B54_RS07485	COG1175	transmembrane transport
C3B54_RS07505	COG0656	L-ascorbic acid biosynthetic process
C3B54_RS07510	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C3B54_RS07535	COG1615	UPF0182 protein
C3B54_RS07575	COG0210	DNA helicase
C3B54_RS07600	COG0513	Belongs to the DEAD box helicase family
C3B54_RS07605	COG0613	PHP domain protein
C3B54_RS07610	COG0006	proline dipeptidase activity
C3B54_RS07615	COG2239	Acts as a magnesium transporter
C3B54_RS07635	COG4122	O-methyltransferase activity
C3B54_RS07645	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C3B54_RS07675	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C3B54_RS07680	COG0473	3-isopropylmalate dehydrogenase activity
C3B54_RS07700	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C3B54_RS07705	COG0440	acetolactate synthase activity
C3B54_RS07715	COG0129	dihydroxy-acid dehydratase activity
C3B54_RS07725	COG0561	phosphatase activity
C3B54_RS07725	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C3B54_RS07735	COG1082	Xylose isomerase domain protein TIM barrel
C3B54_RS07755	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C3B54_RS07775	COG2186	Transcriptional regulator
C3B54_RS07785	COG1028	Short-chain dehydrogenase reductase Sdr
C3B54_RS07790	COG1082	Xylose isomerase domain protein TIM barrel
C3B54_RS07795	COG2084	Dehydrogenase
C3B54_RS07810	COG1054	Belongs to the UPF0176 family
C3B54_RS07820	COG3550	peptidyl-serine autophosphorylation
C3B54_RS07880	COG0653	protein targeting
C3B54_RS07885	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C3B54_RS07890	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C3B54_RS07895	COG5401	PFAM Sporulation and spore germination
C3B54_RS07900	COG5002	protein histidine kinase activity
C3B54_RS07900	COG5000	phosphorelay sensor kinase activity
C3B54_RS07910	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C3B54_RS07915	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C3B54_RS07945	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C3B54_RS07960	COG1083	cytidylyl-transferase
C3B54_RS07965	COG2089	acid synthase
C3B54_RS07980	COG1705	Flagellar rod assembly protein muramidase FlgJ
C3B54_RS07980	COG1388	LysM domain
C3B54_RS08055	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
C3B54_RS08055	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
C3B54_RS08060	COG1132	(ABC) transporter
C3B54_RS08075	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C3B54_RS08095	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C3B54_RS08125	COG0424	maF-like protein
C3B54_RS08130	COG4770	biotin carboxylase activity
C3B54_RS08135	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C3B54_RS08145	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C3B54_RS08155	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C3B54_RS08165	COG1079	Belongs to the binding-protein-dependent transport system permease family
C3B54_RS08170	COG4603	Belongs to the binding-protein-dependent transport system permease family
C3B54_RS08175	COG3845	ABC transporter
C3B54_RS08180	COG1744	ABC transporter substrate-binding protein PnrA-like
C3B54_RS08190	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
C3B54_RS08190	COG0662	Cupin 2, conserved barrel domain protein
C3B54_RS08195	COG0438	transferase activity, transferring glycosyl groups
C3B54_RS08200	COG2009	succinate dehydrogenase
C3B54_RS08215	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C3B54_RS08220	COG0708	Exodeoxyribonuclease III
C3B54_RS08225	COG0180	Tryptophanyl-tRNA synthetase
C3B54_RS08230	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C3B54_RS08245	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C3B54_RS08245	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C3B54_RS08250	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C3B54_RS08280	COG1132	(ABC) transporter
C3B54_RS08285	COG1335	isochorismatase
C3B54_RS08290	COG2027	D-alanyl-D-alanine carboxypeptidase
C3B54_RS08300	COG1216	Glycosyl transferase, family 2
C3B54_RS08310	COG3842	ATPase activity
C3B54_RS08320	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C3B54_RS08325	COG0215	cysteine-tRNA ligase activity
C3B54_RS08330	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C3B54_RS08330	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C3B54_RS08335	COG1329	Transcriptional regulator
C3B54_RS08345	COG0745	RESPONSE REGULATOR receiver
C3B54_RS08350	COG5002	protein histidine kinase activity
C3B54_RS08355	COG0704	Plays a role in the regulation of phosphate uptake
C3B54_RS08360	COG0588	phosphoglycerate mutase activity
C3B54_RS08370	COG0745	RESPONSE REGULATOR receiver
C3B54_RS08375	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C3B54_RS08410	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C3B54_RS08410	COG2755	lipolytic protein G-D-S-L family
C3B54_RS08415	COG0297	glycogen (starch) synthase activity
C3B54_RS08435	COG1266	CAAX protease self-immunity
C3B54_RS08445	COG0579	oxidoreductase
C3B54_RS08470	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C3B54_RS08495	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C3B54_RS08515	COG2801	Transposase and inactivated derivatives
C3B54_RS08515	COG3415	Transposase
C3B54_RS08520	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C3B54_RS08520	COG2755	lipolytic protein G-D-S-L family
C3B54_RS08565	COG0222	ribosome binding
C3B54_RS08570	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C3B54_RS08575	COG0081	regulation of translation
C3B54_RS08580	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C3B54_RS08620	COG0366	Alpha amylase catalytic
C3B54_RS08625	COG0739	heme binding
C3B54_RS08630	COG0483	inositol monophosphate 1-phosphatase activity
C3B54_RS08645	COG1666	GTP binding
C3B54_RS08650	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C3B54_RS08670	COG0142	geranyltranstransferase activity
C3B54_RS08675	COG2226	methyltransferase
C3B54_RS08685	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
C3B54_RS08700	COG1575	Belongs to the MenA family. Type 1 subfamily
C3B54_RS08715	COG1132	(ABC) transporter