locus-tag	class	description
KS4_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
KS4_RS00050	COG0714	Associated with various cellular activities
KS4_RS00090	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
KS4_RS00110	COG0438	transferase activity, transferring glycosyl groups
KS4_RS00115	COG0583	DNA-binding transcription factor activity
KS4_RS00120	COG0067	glutamate synthase
KS4_RS00120	COG0069	glutamate synthase activity
KS4_RS00120	COG0070	glutamate synthase
KS4_RS00125	COG0493	'glutamate synthase
KS4_RS00130	COG0385	Bile acid
KS4_RS00150	COG0384	phenazine biosynthesis protein PhzF
KS4_RS00165	COG2095	MarC family integral membrane protein
KS4_RS00190	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KS4_RS00230	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KS4_RS00235	COG0232	Belongs to the dGTPase family. Type 2 subfamily
KS4_RS00240	COG2155	Conserved Protein
KS4_RS00250	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
KS4_RS00255	COG0220	tRNA (guanine-N7-)-methyltransferase activity
KS4_RS00270	COG0469	pyruvate kinase activity
KS4_RS00275	COG2204	response regulator
KS4_RS00280	COG0534	Mate efflux family protein
KS4_RS00350	COG0217	transcriptional regulatory protein
KS4_RS00410	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
KS4_RS00420	COG2226	methyltransferase
KS4_RS00495	COG1181	Belongs to the D-alanine--D-alanine ligase family
KS4_RS00500	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KS4_RS00550	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
KS4_RS00600	COG0840	transmembrane signaling receptor activity
KS4_RS00625	COG2010	Cytochrome c
KS4_RS00645	COG2217	Heavy metal translocating P-type atpase
KS4_RS00655	COG0753	catalase activity
KS4_RS00665	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
KS4_RS00700	COG0508	dehydrogenase complex catalyzes the overall conversion of
KS4_RS00710	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KS4_RS00720	COG0529	Catalyzes the synthesis of activated sulfate
KS4_RS00730	COG2165	general secretion pathway protein
KS4_RS00745	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
KS4_RS00760	COG1160	GTP binding
KS4_RS00775	COG1214	PFAM Peptidase M22, glycoprotease
KS4_RS00780	COG3481	metal-dependent phosphohydrolase, HD sub domain
KS4_RS00835	COG0659	secondary active sulfate transmembrane transporter activity
KS4_RS00845	COG1733	regulation of RNA biosynthetic process
KS4_RS00885	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
KS4_RS00895	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
KS4_RS00900	COG2890	protein-(glutamine-N5) methyltransferase activity
KS4_RS00925	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
KS4_RS00940	COG0022	dehydrogenase e1 component
KS4_RS00940	COG0508	dehydrogenase complex catalyzes the overall conversion of
KS4_RS00945	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KS4_RS00960	COG0729	surface antigen
KS4_RS00970	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KS4_RS00975	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KS4_RS00975	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
KS4_RS00980	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KS4_RS01020	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KS4_RS01040	COG3023	N-Acetylmuramoyl-L-alanine amidase
KS4_RS01045	COG2835	tetraacyldisaccharide 4'-kinase activity
KS4_RS01055	COG2186	Transcriptional regulator
KS4_RS01080	COG0673	inositol 2-dehydrogenase activity
KS4_RS01095	COG1904	glucuronate isomerase
KS4_RS01100	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
KS4_RS01120	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
KS4_RS01180	COG1657	PFAM Prenyltransferase squalene oxidase
KS4_RS01205	COG2186	Transcriptional regulator
KS4_RS01210	COG0247	lactate metabolic process
KS4_RS01210	COG0277	FAD linked oxidase domain protein
KS4_RS01220	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KS4_RS01230	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
KS4_RS01260	COG0826	peptidase U32
KS4_RS01320	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
KS4_RS01325	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
KS4_RS01390	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
KS4_RS01415	COG4284	Utp--glucose-1-phosphate uridylyltransferase
KS4_RS01435	COG3458	cephalosporin-C deacetylase activity
KS4_RS01455	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
KS4_RS01460	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KS4_RS01475	COG0205	6-phosphofructokinase activity
KS4_RS01490	COG2723	6-phospho-beta-galactosidase activity
KS4_RS01510	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
KS4_RS01515	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KS4_RS01560	COG0110	maltose O-acetyltransferase activity
KS4_RS01570	COG0110	maltose O-acetyltransferase activity
KS4_RS01625	COG1874	Beta-galactosidase
KS4_RS01630	COG3118	belongs to the thioredoxin family
KS4_RS01635	COG0612	Peptidase, M16
KS4_RS01645	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KS4_RS01645	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KS4_RS01655	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KS4_RS01665	COG0724	RNA recognition motif
KS4_RS01670	COG2207	Transcriptional regulator
KS4_RS01695	COG1595	DNA-templated transcription, initiation
KS4_RS01700	COG0840	transmembrane signaling receptor activity
KS4_RS01705	COG1418	mRNA catabolic process
KS4_RS01710	COG1309	transcriptional regulator
KS4_RS01755	COG2032	superoxide dismutase activity
KS4_RS01760	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
KS4_RS01790	COG0519	Catalyzes the synthesis of GMP from XMP
KS4_RS01805	COG0471	metal ion transport
KS4_RS01835	COG1012	belongs to the aldehyde dehydrogenase family
KS4_RS01840	COG0477	Major facilitator Superfamily
KS4_RS01840	COG2814	Major facilitator Superfamily
KS4_RS01845	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
KS4_RS01870	COG3494	Protein of unknown function (DUF1009)
KS4_RS01880	COG0438	transferase activity, transferring glycosyl groups
KS4_RS01895	COG2226	methyltransferase
KS4_RS01900	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KS4_RS01910	COG0383	alpha-mannosidase activity
KS4_RS01945	COG0714	Associated with various cellular activities
KS4_RS01965	COG0702	epimerase
KS4_RS01970	COG0259	pyridoxamine-phosphate oxidase activity
KS4_RS01975	COG2135	peptidase activity
KS4_RS01980	COG1187	pseudouridine synthase activity
KS4_RS01985	COG1137	ATPase activity
KS4_RS01995	COG0438	transferase activity, transferring glycosyl groups
KS4_RS02005	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KS4_RS02020	COG0667	Aldo Keto reductase
KS4_RS02025	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
KS4_RS02045	COG3314	Sporulation integral membrane protein YlbJ
KS4_RS02090	COG0504	CTP synthase activity
KS4_RS02100	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
KS4_RS02110	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
KS4_RS02115	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KS4_RS02145	COG0211	Belongs to the bacterial ribosomal protein bL27 family
KS4_RS02150	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
KS4_RS02160	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
KS4_RS02165	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
KS4_RS02190	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
KS4_RS02195	COG4864	UPF0365 protein
KS4_RS02210	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KS4_RS02225	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
KS4_RS02240	COG0641	radical SAM
KS4_RS02255	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
KS4_RS02260	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
KS4_RS02265	COG1074	ATP-dependent DNA helicase activity
KS4_RS02275	COG2207	Transcriptional regulator
KS4_RS02280	COG1486	melibiose metabolic process
KS4_RS02290	COG0704	Plays a role in the regulation of phosphate uptake
KS4_RS02295	COG0306	phosphate transporter
KS4_RS02300	COG1392	Phosphate transport regulator
KS4_RS02310	COG5002	protein histidine kinase activity
KS4_RS02315	COG0745	RESPONSE REGULATOR receiver
KS4_RS02355	COG2137	regulation of response to DNA damage stimulus
KS4_RS02375	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
KS4_RS02405	COG3089	Belongs to the UPF0270 family
KS4_RS02415	COG1064	alcohol dehydrogenase
KS4_RS02425	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
KS4_RS02430	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KS4_RS02445	COG1597	lipid kinase activity
KS4_RS02455	COG1139	Iron-sulfur cluster binding protein
KS4_RS02475	COG1032	radical SAM domain protein
KS4_RS02490	COG0477	Major facilitator Superfamily
KS4_RS02500	COG2095	MarC family integral membrane protein
KS4_RS02505	COG0085	RNA polymerase activity
KS4_RS02510	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
KS4_RS02515	COG1028	Short-chain dehydrogenase reductase Sdr
KS4_RS02520	COG1309	transcriptional regulator
KS4_RS02535	COG1678	Uncharacterized ACR, COG1678
KS4_RS02560	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KS4_RS02565	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KS4_RS02570	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KS4_RS02575	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
KS4_RS02605	COG3852	Histidine kinase
KS4_RS02610	COG1278	Cold shock
KS4_RS02615	COG1185	polyribonucleotide nucleotidyltransferase activity
KS4_RS02620	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
KS4_RS02640	COG2391	methyltransferase activity
KS4_RS02650	COG0513	Belongs to the DEAD box helicase family
KS4_RS02660	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
KS4_RS02665	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KS4_RS02670	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KS4_RS02680	COG0657	acetylesterase activity
KS4_RS02695	COG0482	sulfurtransferase activity
KS4_RS02705	COG0812	UDP-N-acetylmuramate dehydrogenase activity
KS4_RS02710	COG1271	oxidase subunit
KS4_RS02715	COG1294	oxidase, subunit
KS4_RS02725	COG0828	Belongs to the bacterial ribosomal protein bS21 family
KS4_RS02735	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
KS4_RS02775	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
KS4_RS02780	COG0037	tRNA processing
KS4_RS02785	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
KS4_RS02800	COG0592	DNA-directed DNA polymerase activity
KS4_RS02820	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
KS4_RS02830	COG1322	Protein conserved in bacteria
KS4_RS02835	COG0438	transferase activity, transferring glycosyl groups
KS4_RS02850	COG2855	membrane
KS4_RS02855	COG0583	DNA-binding transcription factor activity
KS4_RS02860	COG0250	Participates in transcription elongation, termination and antitermination
KS4_RS02890	COG0267	Belongs to the bacterial ribosomal protein bL33 family
KS4_RS02895	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
KS4_RS02905	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
KS4_RS02905	COG0316	Belongs to the HesB IscA family
KS4_RS02910	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
KS4_RS02935	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
KS4_RS02955	COG2326	polyphosphate kinase activity
KS4_RS02970	COG1595	DNA-templated transcription, initiation
KS4_RS02990	COG0028	Belongs to the TPP enzyme family
KS4_RS03010	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
KS4_RS03010	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
KS4_RS03020	COG2385	sporulation resulting in formation of a cellular spore
KS4_RS03035	COG0577	efflux transmembrane transporter activity
KS4_RS03070	COG0673	inositol 2-dehydrogenase activity
KS4_RS03080	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
KS4_RS03085	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KS4_RS03090	COG1136	(ABC) transporter
KS4_RS03095	COG4591	ABC-type transport system involved in lipoprotein release permease component
KS4_RS03100	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
KS4_RS03120	COG0336	Belongs to the RNA methyltransferase TrmD family
KS4_RS03130	COG0228	four-way junction DNA binding
KS4_RS03140	COG4608	Belongs to the ABC transporter superfamily
KS4_RS03150	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KS4_RS03155	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
KS4_RS03165	COG1132	(ABC) transporter
KS4_RS03170	COG1132	(ABC) transporter
KS4_RS03205	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
KS4_RS03230	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KS4_RS03235	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KS4_RS03250	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
KS4_RS03255	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
KS4_RS03260	COG2877	3-deoxy-8-phosphooctulonate synthase activity
KS4_RS03275	COG0714	Associated with various cellular activities
KS4_RS03290	COG0735	belongs to the Fur family
KS4_RS03295	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
KS4_RS03300	COG2199	diguanylate cyclase activity
KS4_RS03300	COG2203	Gaf domain
KS4_RS03310	COG0740	serine-type endopeptidase activity
KS4_RS03315	COG2076	Multidrug Resistance protein
KS4_RS03320	COG1619	proteins homologs of microcin C7 resistance protein MccF
KS4_RS03325	COG0772	Belongs to the SEDS family
KS4_RS03330	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KS4_RS03340	COG0142	geranyltranstransferase activity
KS4_RS03345	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
KS4_RS03365	COG2217	Heavy metal translocating P-type atpase
KS4_RS03390	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
KS4_RS03400	COG1119	ATPase activity
KS4_RS03415	COG4786	Flagellar basal body rod
KS4_RS03420	COG4786	Flagellar basal body rod
KS4_RS03430	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
KS4_RS03435	COG1706	bacterial-type flagellum-dependent cell motility
KS4_RS03460	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
KS4_RS03465	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
KS4_RS03470	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
KS4_RS03520	COG0495	leucyl-tRNA aminoacylation
KS4_RS03585	COG0305	Participates in initiation and elongation during chromosome replication
KS4_RS03605	COG0535	radical SAM domain protein
KS4_RS03610	COG0535	radical SAM domain protein
KS4_RS03615	COG1218	3'(2'),5'-bisphosphate nucleotidase
KS4_RS03625	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
KS4_RS03625	COG2755	lipolytic protein G-D-S-L family
KS4_RS03635	COG0596	Alpha beta hydrolase
KS4_RS03650	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
KS4_RS03665	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
KS4_RS03695	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
KS4_RS03700	COG2207	Transcriptional regulator
KS4_RS03700	COG1609	Transcriptional regulator
KS4_RS03705	COG0450	alkyl hydroperoxide reductase
KS4_RS03730	COG0673	inositol 2-dehydrogenase activity
KS4_RS03740	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
KS4_RS03755	COG1280	lysine exporter protein (LysE YggA)
KS4_RS03765	COG0300	oxidoreductase activity
KS4_RS03770	COG0667	Aldo Keto reductase
KS4_RS03835	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
KS4_RS03855	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
KS4_RS03860	COG0463	Glycosyl transferase, family 2
KS4_RS03875	COG1691	(AIR) carboxylase
KS4_RS03880	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
KS4_RS03880	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
KS4_RS03890	COG2378	regulation of single-species biofilm formation
KS4_RS03900	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
KS4_RS03920	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KS4_RS03925	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
KS4_RS03950	COG0788	formyltetrahydrofolate deformylase activity
KS4_RS03955	COG1191	sigma factor activity
KS4_RS03960	COG0704	Plays a role in the regulation of phosphate uptake
KS4_RS03965	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
KS4_RS03975	COG0573	inorganic phosphate transmembrane transporter activity
KS4_RS03980	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
KS4_RS04010	COG0488	(ABC) transporter
KS4_RS04020	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KS4_RS04025	COG0288	reversible hydration of carbon dioxide
KS4_RS04040	COG0233	cytoplasmic translational termination
KS4_RS04050	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
KS4_RS04085	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KS4_RS04095	COG3706	GGDEF domain
KS4_RS04105	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
KS4_RS04120	COG0356	it plays a direct role in the translocation of protons across the membrane
KS4_RS04125	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
KS4_RS04130	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
KS4_RS04140	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
KS4_RS04155	COG0492	ferredoxin-NADP+ reductase activity
KS4_RS04165	COG3250	beta-galactosidase activity
KS4_RS04180	COG2089	acid synthase
KS4_RS04205	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KS4_RS04230	COG3158	transport of potassium into the cell
KS4_RS04245	COG1335	isochorismatase
KS4_RS04250	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
KS4_RS04285	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KS4_RS04290	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KS4_RS04295	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KS4_RS04300	COG1028	Short-chain dehydrogenase reductase Sdr
KS4_RS04330	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
KS4_RS04360	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KS4_RS04375	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KS4_RS04395	COG0673	inositol 2-dehydrogenase activity
KS4_RS04405	COG0811	peptide transport
KS4_RS04465	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KS4_RS04475	COG0285	dihydrofolate synthase activity
KS4_RS04485	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
KS4_RS04505	COG0066	3-isopropylmalate dehydratase activity
KS4_RS04520	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
KS4_RS04560	COG2813	Specifically methylates the guanine in position
KS4_RS04560	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KS4_RS04570	COG0268	Binds directly to 16S ribosomal RNA
KS4_RS04580	COG0195	Participates in both transcription termination and antitermination
KS4_RS04585	COG3170	Tfp pilus assembly protein FimV
KS4_RS04585	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
KS4_RS04590	COG1550	Protein conserved in bacteria
KS4_RS04595	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
KS4_RS04605	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
KS4_RS04615	COG0187	DNA topoisomerase II activity
KS4_RS04620	COG0519	Catalyzes the synthesis of GMP from XMP
KS4_RS04635	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
KS4_RS04655	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
KS4_RS04670	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
KS4_RS04685	COG0798	PFAM Bile acid sodium symporter
KS4_RS04695	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
KS4_RS04700	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
KS4_RS04700	COG0165	Argininosuccinate lyase
KS4_RS04705	COG0392	lysyltransferase activity
KS4_RS04745	COG0322	excinuclease ABC activity
KS4_RS04760	COG1872	DUF167
KS4_RS04780	COG0395	ABC-type sugar transport system, permease component
KS4_RS04785	COG1175	transmembrane transport
KS4_RS04795	COG0546	phosphoglycolate phosphatase activity
KS4_RS04800	COG0426	domain, Protein
KS4_RS04800	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KS4_RS04815	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KS4_RS04820	COG0297	glycogen (starch) synthase activity
KS4_RS04820	COG0438	transferase activity, transferring glycosyl groups
KS4_RS04825	COG0101	tRNA pseudouridine synthase activity
KS4_RS04835	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
KS4_RS04840	COG0179	Fumarylacetoacetate (FAA) hydrolase
KS4_RS04855	COG0105	UTP biosynthetic process
KS4_RS04890	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KS4_RS04905	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
KS4_RS04930	COG1774	PSP1 C-terminal conserved region
KS4_RS04960	COG0443	Heat shock 70 kDa protein
KS4_RS04965	COG2239	Acts as a magnesium transporter
KS4_RS04970	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KS4_RS04975	COG4806	L-rhamnose isomerase
KS4_RS05020	COG0270	DNA (cytosine-5-)-methyltransferase activity
KS4_RS05070	COG1061	Type III restriction enzyme res subunit
KS4_RS05080	COG1475	DNA binding
KS4_RS05205	COG3586	endonuclease activity
KS4_RS05210	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KS4_RS05230	COG1595	DNA-templated transcription, initiation
KS4_RS05245	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KS4_RS05275	COG0564	pseudouridine synthase activity
KS4_RS05325	COG3091	SprT-like family
KS4_RS05345	COG0402	S-adenosylhomocysteine deaminase activity
KS4_RS05350	COG2084	Dehydrogenase
KS4_RS05370	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KS4_RS05380	COG0542	response to heat
KS4_RS05385	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KS4_RS05400	COG3706	GGDEF domain
KS4_RS05405	COG3706	GGDEF domain
KS4_RS05415	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
KS4_RS05430	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
KS4_RS05440	COG4464	protein tyrosine phosphatase activity
KS4_RS05445	COG1058	Belongs to the CinA family
KS4_RS05445	COG1546	Belongs to the CinA family
KS4_RS05450	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
KS4_RS05470	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
KS4_RS05480	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
KS4_RS05485	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KS4_RS05495	COG0404	The glycine cleavage system catalyzes the degradation of glycine
KS4_RS05500	COG0716	FMN binding
KS4_RS05525	COG0768	penicillin binding
KS4_RS05540	COG0275	rRNA processing
KS4_RS05545	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
KS4_RS05555	COG0604	alcohol dehydrogenase
KS4_RS05575	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
KS4_RS05590	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
KS4_RS05600	COG0805	protein transport
KS4_RS05630	COG0628	permease
KS4_RS05645	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
KS4_RS05650	COG1448	Aminotransferase
KS4_RS05670	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
KS4_RS05690	COG4191	Histidine kinase
KS4_RS05695	COG2204	response regulator
KS4_RS05700	COG1815	bacterial-type flagellum-dependent cell motility
KS4_RS05705	COG1558	bacterial-type flagellum-dependent cell motility
KS4_RS05710	COG1677	Flagellar hook-basal body complex protein FliE
KS4_RS05720	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
KS4_RS05770	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
KS4_RS05795	COG1338	Plays a role in the flagellum-specific transport system
KS4_RS05805	COG1684	flagellar biosynthetic protein fliR
KS4_RS05810	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
KS4_RS05815	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
KS4_RS05825	COG1419	protein localization to endoplasmic reticulum
KS4_RS05840	COG1191	sigma factor activity
KS4_RS05850	COG0018	arginyl-trna synthetase
KS4_RS05865	COG1215	transferase activity, transferring glycosyl groups
KS4_RS05870	COG0823	Involved in the tonB-independent uptake of proteins
KS4_RS05885	COG4974	Belongs to the 'phage' integrase family
KS4_RS05890	COG1741	Belongs to the pirin family
KS4_RS05930	COG1222	aaa ATPase
KS4_RS05960	COG0733	neurotransmitter:sodium symporter activity
KS4_RS05970	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KS4_RS05995	COG0509	glycine decarboxylation via glycine cleavage system
KS4_RS06005	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KS4_RS06010	COG1523	belongs to the glycosyl hydrolase 13 family
KS4_RS06020	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KS4_RS06025	COG1609	Transcriptional regulator
KS4_RS06050	COG2160	L-arabinose isomerase activity
KS4_RS06060	COG1069	ribulokinase activity
KS4_RS06065	COG2207	Transcriptional regulator
KS4_RS06065	COG1609	Transcriptional regulator
KS4_RS06075	COG0315	cyclic pyranopterin monophosphate synthase activity
KS4_RS06085	COG1063	alcohol dehydrogenase
KS4_RS06090	COG0515	serine threonine protein kinase
KS4_RS06090	COG2815	serine threonine protein kinase
KS4_RS06110	COG4962	Type ii secretion system protein e
KS4_RS06125	COG3451	type IV secretory pathway VirB4
KS4_RS06155	COG2948	multi-organism process
KS4_RS06165	COG1584	GPR1 FUN34 yaaH family protein
KS4_RS06180	COG1070	Carbohydrate kinase
KS4_RS06245	COG0459	protein refolding
KS4_RS06255	COG0459	protein refolding
KS4_RS06260	COG0484	heat shock protein binding
KS4_RS06265	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
KS4_RS06285	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
KS4_RS06285	COG0456	acetyltransferase
KS4_RS06290	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
KS4_RS06290	COG1013	pyruvate-flavodoxin oxidoreductase activity
KS4_RS06290	COG0674	pyruvate-flavodoxin oxidoreductase activity
KS4_RS06295	COG1233	COG1233 Phytoene dehydrogenase and related
KS4_RS06300	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
KS4_RS06325	COG0653	protein targeting
KS4_RS06335	COG2188	Transcriptional regulator
KS4_RS06360	COG1573	uracil-dna glycosylase
KS4_RS06370	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
KS4_RS06385	COG0180	Tryptophanyl-tRNA synthetase
KS4_RS06395	COG0135	phosphoribosylanthranilate isomerase activity
KS4_RS06415	COG1045	serine acetyltransferase
KS4_RS06440	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
KS4_RS06445	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
KS4_RS06455	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KS4_RS06460	COG0698	ribose 5-phosphate isomerase
KS4_RS06475	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KS4_RS06515	COG0138	bifunctional purine biosynthesis protein purh
KS4_RS06535	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
KS4_RS06545	COG2815	serine threonine protein kinase
KS4_RS06545	COG0515	serine threonine protein kinase
KS4_RS06550	COG0142	geranyltranstransferase activity
KS4_RS06565	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KS4_RS06565	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
KS4_RS06575	COG0724	RNA recognition motif
KS4_RS06595	COG0203	ribosomal protein L17
KS4_RS06600	COG0202	RNA polymerase activity
KS4_RS06605	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
KS4_RS06610	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
KS4_RS06615	COG0257	Belongs to the bacterial ribosomal protein bL36 family
KS4_RS06625	COG0024	Methionine aminopeptidase
KS4_RS06630	COG0201	protein transport
KS4_RS06635	COG0200	Binds to the 23S rRNA
KS4_RS06640	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
KS4_RS06645	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
KS4_RS06650	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
KS4_RS06655	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
KS4_RS06660	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
KS4_RS06665	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
KS4_RS06675	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
KS4_RS06680	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
KS4_RS06685	COG0255	Belongs to the universal ribosomal protein uL29 family
KS4_RS06690	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
KS4_RS06695	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
KS4_RS06710	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
KS4_RS06715	COG0089	rRNA binding
KS4_RS06720	COG0088	Forms part of the polypeptide exit tunnel
KS4_RS06725	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
KS4_RS06730	COG0051	transcription antitermination factor activity, RNA binding
KS4_RS06735	COG0076	glutamate decarboxylase activity
KS4_RS06745	COG1129	ABC transporter
KS4_RS06750	COG1172	Belongs to the binding-protein-dependent transport system permease family
KS4_RS06755	COG3250	beta-galactosidase activity
KS4_RS06770	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KS4_RS06800	COG0175	sulfate reduction
KS4_RS06805	COG2895	sulfate adenylyltransferase (ATP) activity
KS4_RS06805	COG0529	Catalyzes the synthesis of activated sulfate
KS4_RS06815	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
KS4_RS06820	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
KS4_RS06825	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
KS4_RS06830	COG1414	Transcriptional regulator
KS4_RS06840	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
KS4_RS06845	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
KS4_RS06870	COG4536	flavin adenine dinucleotide binding
KS4_RS06875	COG4535	Mg2 and Co2 transporter CorC
KS4_RS06885	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
KS4_RS06895	COG0395	ABC-type sugar transport system, permease component
KS4_RS06900	COG1175	transmembrane transport
KS4_RS06915	COG3256	nitric oxide reductase
KS4_RS06935	COG0004	ammonium transporteR
KS4_RS06995	COG0202	RNA polymerase activity
KS4_RS07000	COG0463	Glycosyl transferase, family 2
KS4_RS07005	COG0488	(ABC) transporter
KS4_RS07025	COG2207	Transcriptional regulator
KS4_RS07040	COG1175	transmembrane transport
KS4_RS07045	COG0395	ABC-type sugar transport system, permease component
KS4_RS07070	COG0612	Peptidase, M16
KS4_RS07105	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KS4_RS07130	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
KS4_RS07140	COG0432	Pfam Uncharacterised protein family UPF0047
KS4_RS07145	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KS4_RS07150	COG1940	carbohydrate kinase activity
KS4_RS07155	COG0154	amidase activity
KS4_RS07160	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KS4_RS07165	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
KS4_RS07170	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
KS4_RS07205	COG1874	Beta-galactosidase
KS4_RS07220	COG4956	integral membrane protein (PIN domain superfamily)
KS4_RS07230	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
KS4_RS07235	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
KS4_RS07260	COG1562	ergosterol biosynthetic process
KS4_RS07265	COG1562	ergosterol biosynthetic process
KS4_RS07270	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
KS4_RS07275	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KS4_RS07280	COG1196	nuclear chromosome segregation
KS4_RS07280	COG3264	Mechanosensitive ion channel
KS4_RS07285	COG3046	protein related to deoxyribodipyrimidine photolyase
KS4_RS07300	COG3209	COG3209 Rhs family protein
KS4_RS07340	COG0475	glutathione-regulated potassium exporter activity
KS4_RS07350	COG5001	Diguanylate cyclase
KS4_RS07350	COG3300	MHYT domain
KS4_RS07355	COG1609	Transcriptional regulator
KS4_RS07395	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
KS4_RS07400	COG0540	Belongs to the ATCase OTCase family
KS4_RS07405	COG0194	GDP metabolic process
KS4_RS07410	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
KS4_RS07415	COG0859	PFAM glycosyl transferase family 9
KS4_RS07425	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
KS4_RS07430	COG0049	tRNA binding
KS4_RS07435	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KS4_RS07480	COG0318	PFAM AMP-dependent synthetase and ligase
KS4_RS07480	COG0204	Acyl-transferase
KS4_RS07490	COG1469	GTP cyclohydrolase I activity
KS4_RS07500	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
KS4_RS07505	COG2096	Adenosyltransferase
KS4_RS07515	COG0564	pseudouridine synthase activity
KS4_RS07560	COG3104	oligopeptide transport
KS4_RS07655	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KS4_RS07680	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KS4_RS07690	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
KS4_RS07695	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
KS4_RS07725	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
KS4_RS07735	COG1966	Carbon starvation protein
KS4_RS07745	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
KS4_RS07750	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
KS4_RS07760	COG0484	heat shock protein binding
KS4_RS07775	COG0574	Belongs to the PEP-utilizing enzyme family
KS4_RS07775	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KS4_RS07800	COG0616	signal peptide processing
KS4_RS07810	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
KS4_RS07825	COG3459	Glycosyltransferase 36 associated
KS4_RS07865	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
KS4_RS07870	COG0367	asparagine synthase
KS4_RS07885	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KS4_RS07890	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
KS4_RS07910	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KS4_RS07915	COG0287	Prephenate dehydrogenase
KS4_RS07920	COG0825	malonyl-CoA metabolic process
KS4_RS07945	COG2183	response to ionizing radiation
KS4_RS07965	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
KS4_RS07970	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
KS4_RS07975	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
KS4_RS07985	COG0193	aminoacyl-tRNA hydrolase activity
KS4_RS07990	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KS4_RS07990	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KS4_RS07990	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KS4_RS07995	COG0514	ATP-dependent DNA helicase (RecQ)
KS4_RS08000	COG1131	(ABC) transporter
KS4_RS08025	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KS4_RS08035	COG3869	Catalyzes the specific phosphorylation of arginine residues in
KS4_RS08040	COG3880	PFAM UvrB UvrC protein
KS4_RS08045	COG1606	tRNA processing
KS4_RS08065	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KS4_RS08070	COG1612	heme a metabolic process
KS4_RS08075	COG0109	protoheme IX farnesyltransferase activity
KS4_RS08095	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
KS4_RS08100	COG1472	Belongs to the glycosyl hydrolase 3 family
KS4_RS08120	COG0745	RESPONSE REGULATOR receiver
KS4_RS08125	COG1560	Kdo2-lipid A biosynthetic process
KS4_RS08130	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
KS4_RS08150	COG2239	Acts as a magnesium transporter
KS4_RS08155	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
KS4_RS08160	COG1609	Transcriptional regulator
KS4_RS08165	COG0131	Imidazoleglycerol-phosphate dehydratase
KS4_RS08170	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KS4_RS08180	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
KS4_RS08200	COG2204	response regulator
KS4_RS08210	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
KS4_RS08215	COG3525	Glycosyl hydrolase, family 20, catalytic domain
KS4_RS08225	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
KS4_RS08255	COG0360	Binds together with S18 to 16S ribosomal RNA
KS4_RS08260	COG0629	single-stranded DNA binding
KS4_RS08265	COG0359	binds to the 23S rRNA
KS4_RS08280	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KS4_RS08285	COG1012	belongs to the aldehyde dehydrogenase family
KS4_RS08290	COG3189	MarR family transcriptional regulator
KS4_RS08295	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
KS4_RS08310	COG0012	GTP binding
KS4_RS08320	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
KS4_RS08330	COG1648	precorrin-2 dehydrogenase activity
KS4_RS08330	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KS4_RS08345	COG0175	sulfate reduction
KS4_RS08350	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
KS4_RS08355	COG0602	queuosine metabolic process
KS4_RS08360	COG0720	synthase
KS4_RS08370	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
KS4_RS08390	COG1716	ATPase activity
KS4_RS08395	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KS4_RS08400	COG0653	protein targeting
KS4_RS08410	COG0045	succinate-CoA ligase (ADP-forming) activity
KS4_RS08420	COG0668	transmembrane transport
KS4_RS08430	COG1819	glycosyl
KS4_RS08460	COG1136	(ABC) transporter
KS4_RS08465	COG0714	Associated with various cellular activities
KS4_RS08480	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
KS4_RS08500	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KS4_RS08505	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KS4_RS08505	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KS4_RS08510	COG0252	asparaginase activity
KS4_RS08530	COG0820	rRNA (adenine-C2-)-methyltransferase activity
KS4_RS08665	COG2176	DNA-directed DNA polymerase activity
KS4_RS08725	COG3012	SEC-C Motif Domain Protein
KS4_RS08725	COG1405	negative regulation of cell septum assembly
KS4_RS08760	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KS4_RS08790	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KS4_RS08790	COG2111	Na H antiporter
KS4_RS08795	COG2111	Na H antiporter
KS4_RS08800	COG1006	Multisubunit Na H antiporter MnhC subunit
KS4_RS08805	COG0651	ATP synthesis coupled electron transport
KS4_RS08815	COG2212	antiporter activity
KS4_RS08820	COG1320	monovalent cation:proton antiporter activity
KS4_RS08835	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KS4_RS08845	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KS4_RS08855	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
KS4_RS08860	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
KS4_RS08880	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
KS4_RS08890	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
KS4_RS08895	COG0058	SHG alpha-glucan phosphorylase activity
KS4_RS08900	COG0811	peptide transport
KS4_RS08910	COG4566	intracellular signal transduction
KS4_RS08915	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
KS4_RS08920	COG0167	dihydroorotate dehydrogenase activity
KS4_RS08925	COG1040	competence protein
KS4_RS08930	COG0072	phenylalanine-tRNA ligase activity
KS4_RS08945	COG0038	chloride channel
KS4_RS08965	COG1758	RNA polymerase activity
KS4_RS08970	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
KS4_RS08985	COG0436	Aminotransferase
KS4_RS08990	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KS4_RS09030	COG0708	Exodeoxyribonuclease III
KS4_RS09050	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
KS4_RS09055	COG3250	beta-galactosidase activity
KS4_RS09060	COG0544	peptidyl-prolyl cis-trans isomerase activity
KS4_RS09070	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
KS4_RS09075	COG0793	Belongs to the peptidase S41A family
KS4_RS09080	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
KS4_RS09090	COG0657	acetylesterase activity
KS4_RS09100	COG0047	phosphoribosylformylglycinamidine synthase activity
KS4_RS09105	COG2264	protein methyltransferase activity
KS4_RS09120	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
KS4_RS09130	COG1309	transcriptional regulator
KS4_RS09135	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
KS4_RS09145	COG1069	ribulokinase activity
KS4_RS09150	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KS4_RS09160	COG0717	Belongs to the dCTP deaminase family
KS4_RS09165	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
KS4_RS09170	COG0196	riboflavin kinase activity
KS4_RS09175	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
KS4_RS09180	COG0571	ribonuclease III activity
KS4_RS09195	COG0230	Belongs to the bacterial ribosomal protein bL34 family
KS4_RS09200	COG0148	phosphopyruvate hydratase activity
KS4_RS09220	COG1199	ATP-dependent helicase activity
KS4_RS09230	COG0222	ribosome binding
KS4_RS09235	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
KS4_RS09240	COG0081	regulation of translation
KS4_RS09255	COG0800	Aldolase
KS4_RS09280	COG4821	SIS domain
KS4_RS09290	COG1028	Short-chain dehydrogenase reductase Sdr
KS4_RS09300	COG3876	Protein conserved in bacteria
KS4_RS09315	COG1652	LysM domain
KS4_RS09320	COG1349	DNA-binding transcription factor activity
KS4_RS09330	COG0235	Class ii aldolase
KS4_RS09365	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
KS4_RS09370	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
KS4_RS09380	COG4869	propanediol catabolic process
KS4_RS09395	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
KS4_RS09400	COG0237	dephospho-CoA kinase activity
KS4_RS09410	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KS4_RS09425	COG1696	Membrane protein involved in D-alanine export
KS4_RS09445	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KS4_RS09450	COG1459	type II secretion system
KS4_RS09485	COG0537	adenosine 5'-monophosphoramidase activity
KS4_RS09500	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
KS4_RS09505	COG0242	peptide deformylase activity
KS4_RS09510	COG0776	regulation of translation
KS4_RS09515	COG0156	8-amino-7-oxononanoate synthase activity
KS4_RS09530	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KS4_RS09535	COG0489	protein tyrosine kinase activity
KS4_RS09545	COG1131	(ABC) transporter
KS4_RS09560	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
KS4_RS09585	COG0535	radical SAM domain protein
KS4_RS09590	COG0357	Ribosomal RNA small subunit methyltransferase G
KS4_RS09595	COG0772	Belongs to the SEDS family
KS4_RS09605	COG0355	proton-transporting ATP synthase activity, rotational mechanism
KS4_RS09620	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KS4_RS09625	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
KS4_RS09630	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
KS4_RS09645	COG0436	Aminotransferase
KS4_RS09655	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KS4_RS09670	COG0438	transferase activity, transferring glycosyl groups
KS4_RS09670	COG0297	glycogen (starch) synthase activity
KS4_RS09675	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KS4_RS09700	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
KS4_RS09705	COG0606	chelatase, subunit chli
KS4_RS09710	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
KS4_RS09720	COG1408	metallophosphoesterase
KS4_RS09730	COG0688	phosphatidylethanolamine metabolic process
KS4_RS09745	COG1929	Belongs to the glycerate kinase type-1 family
KS4_RS09750	COG2264	protein methyltransferase activity
KS4_RS09755	COG0590	tRNA wobble adenosine to inosine editing
KS4_RS09770	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
KS4_RS09785	COG1640	4-alpha-glucanotransferase
KS4_RS09810	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
KS4_RS09815	COG1242	4 iron, 4 sulfur cluster binding
KS4_RS09820	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
KS4_RS09835	COG3409	Peptidoglycan-binding domain 1 protein
KS4_RS09835	COG3267	Type II secretory pathway component ExeA
KS4_RS09840	COG0489	protein tyrosine kinase activity
KS4_RS09860	COG1702	phosphate starvation-inducible protein PhoH
KS4_RS09865	COG1480	7TM receptor with intracellular HD hydrolase
KS4_RS09890	COG1609	Transcriptional regulator
KS4_RS09930	COG2226	methyltransferase
KS4_RS09935	COG0501	Belongs to the peptidase M48B family
KS4_RS09940	COG5012	cobalamin binding
KS4_RS09945	COG1105	Belongs to the carbohydrate kinase PfkB family
KS4_RS09975	COG0515	serine threonine protein kinase
KS4_RS10005	COG0133	tryptophan synthase activity
KS4_RS10015	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
KS4_RS10045	COG2165	general secretion pathway protein
KS4_RS10050	COG0840	transmembrane signaling receptor activity
KS4_RS10060	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
KS4_RS10085	COG2076	Multidrug Resistance protein
KS4_RS10090	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
KS4_RS10095	COG1722	exodeoxyribonuclease VII activity
KS4_RS10100	COG1570	exodeoxyribonuclease VII activity
KS4_RS10105	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KS4_RS10125	COG0505	Belongs to the CarA family
KS4_RS10135	COG1166	arginine decarboxylase activity
KS4_RS10155	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
KS4_RS10155	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
KS4_RS10165	COG0436	Aminotransferase
KS4_RS10180	COG0736	holo-[acyl-carrier-protein] synthase activity
KS4_RS10185	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
KS4_RS10200	COG4221	oxidoreductase activity
KS4_RS10215	COG1013	pyruvate-flavodoxin oxidoreductase activity
KS4_RS10220	COG0674	pyruvate-flavodoxin oxidoreductase activity
KS4_RS10220	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
KS4_RS10230	COG1333	cytochrome c biogenesis protein
KS4_RS10230	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KS4_RS10235	COG2094	Belongs to the DNA glycosylase MPG family
KS4_RS10245	COG2081	HI0933 family
KS4_RS10250	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
KS4_RS10280	COG1070	Carbohydrate kinase
KS4_RS10290	COG3525	Glycosyl hydrolase, family 20, catalytic domain
KS4_RS10300	COG0693	protein deglycase activity
KS4_RS10310	COG0215	cysteine-tRNA ligase activity
KS4_RS10345	COG0521	Mo-molybdopterin cofactor biosynthetic process
KS4_RS10360	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
KS4_RS10365	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
KS4_RS10370	COG1132	(ABC) transporter
KS4_RS10390	COG1034	ATP synthesis coupled electron transport
KS4_RS10395	COG1309	transcriptional regulator
KS4_RS10400	COG0839	Belongs to the complex I subunit 6 family
KS4_RS10405	COG0713	ATP synthesis coupled electron transport
KS4_RS10420	COG1007	ATP synthesis coupled electron transport
KS4_RS10435	COG0406	alpha-ribazole phosphatase activity
KS4_RS10440	COG1309	transcriptional regulator
KS4_RS10455	COG1918	ferrous iron import across plasma membrane
KS4_RS10455	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
KS4_RS10475	COG0159	tryptophan synthase activity
KS4_RS10485	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
KS4_RS10500	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
KS4_RS10520	COG0084	hydrolase, TatD family'
KS4_RS10525	COG1331	Highly conserved protein containing a thioredoxin domain
KS4_RS10545	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
KS4_RS10550	COG0363	glucosamine-6-phosphate deaminase activity
KS4_RS10555	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
KS4_RS10560	COG0445	tRNA wobble uridine modification
KS4_RS10565	COG2239	Acts as a magnesium transporter
KS4_RS10575	COG0114	fumarate hydratase activity
KS4_RS10610	COG1530	ribonuclease E activity
KS4_RS10615	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
KS4_RS10620	COG0750	zinc metalloprotease
KS4_RS10625	COG0706	membrane insertase activity
KS4_RS10630	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
KS4_RS10635	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
KS4_RS10645	COG0415	Belongs to the DNA photolyase family
KS4_RS10655	COG0556	nucleotide-excision repair
KS4_RS10680	COG0662	Cupin 2, conserved barrel domain protein
KS4_RS10680	COG2207	Transcriptional regulator
KS4_RS10695	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
KS4_RS10705	COG0069	glutamate synthase activity
KS4_RS10740	COG1595	DNA-templated transcription, initiation
KS4_RS10760	COG0191	fructose-bisphosphate aldolase activity
KS4_RS10765	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
KS4_RS10790	COG0442	prolyl-tRNA aminoacylation
KS4_RS10845	COG0473	3-isopropylmalate dehydrogenase activity
KS4_RS10865	COG0616	signal peptide processing
KS4_RS10870	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
KS4_RS10895	COG0439	Biotin carboxylase
KS4_RS10900	COG0511	ligase activity, forming carbon-carbon bonds
KS4_RS10905	COG0006	proline dipeptidase activity
KS4_RS10910	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
KS4_RS10920	COG2009	succinate dehydrogenase
KS4_RS10925	COG1053	succinate dehydrogenase
KS4_RS10930	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
KS4_RS10950	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KS4_RS10960	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
KS4_RS10965	COG0616	signal peptide processing
KS4_RS10975	COG1410	methionine synthase
KS4_RS10975	COG0646	methionine synthase
KS4_RS10980	COG1968	undecaprenyl-diphosphatase activity
KS4_RS11010	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
KS4_RS11270	COG0305	Participates in initiation and elongation during chromosome replication
KS4_RS11275	COG0629	single-stranded DNA binding
KS4_RS11380	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KS4_RS11390	COG1176	ABC-type spermidine putrescine transport system, permease component I
KS4_RS11415	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
KS4_RS11425	COG1482	cell wall glycoprotein biosynthetic process
KS4_RS11430	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
KS4_RS11450	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KS4_RS11465	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KS4_RS11470	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KS4_RS11485	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
KS4_RS11490	COG0649	NAD binding
KS4_RS11495	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
KS4_RS11510	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
KS4_RS11525	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
KS4_RS11530	COG0793	Belongs to the peptidase S41A family
KS4_RS11550	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
KS4_RS11550	COG0321	lipoyl(octanoyl) transferase activity
KS4_RS11560	COG0134	indole-3-glycerol-phosphate synthase activity
KS4_RS11590	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
KS4_RS11610	COG0440	acetolactate synthase activity
KS4_RS11615	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
KS4_RS11625	COG2205	protein histidine kinase activity
KS4_RS11625	COG2202	Pas domain
KS4_RS11640	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KS4_RS11645	COG0366	Alpha amylase catalytic
KS4_RS11650	COG0497	DNA recombination
KS4_RS11665	COG2211	Major facilitator Superfamily
KS4_RS11680	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
KS4_RS11685	COG0371	Dehydrogenase
KS4_RS11695	COG0527	aspartate kinase activity
KS4_RS11715	COG0163	prenyltransferase activity
KS4_RS11725	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
KS4_RS11745	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KS4_RS11765	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
KS4_RS11780	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KS4_RS11810	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KS4_RS11820	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KS4_RS11825	COG0569	domain protein
KS4_RS11860	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KS4_RS11885	COG0363	glucosamine-6-phosphate deaminase activity
KS4_RS11895	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
KS4_RS11900	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
KS4_RS11905	COG1132	(ABC) transporter
KS4_RS11910	COG0673	inositol 2-dehydrogenase activity
KS4_RS11915	COG0673	inositol 2-dehydrogenase activity
KS4_RS11935	COG1216	Glycosyl transferase, family 2
KS4_RS11935	COG0463	Glycosyl transferase, family 2
KS4_RS11940	COG1216	Glycosyl transferase, family 2
KS4_RS11955	COG1215	transferase activity, transferring glycosyl groups
KS4_RS11965	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KS4_RS11970	COG0358	DNA primase activity
KS4_RS11980	COG0227	Belongs to the bacterial ribosomal protein bL28 family
KS4_RS11985	COG3321	synthase
KS4_RS11985	COG0604	alcohol dehydrogenase
KS4_RS11995	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
KS4_RS12000	COG0673	inositol 2-dehydrogenase activity
KS4_RS12010	COG1404	Belongs to the peptidase S8 family
KS4_RS12020	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
KS4_RS12035	COG1127	ABC transporter
KS4_RS12070	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
KS4_RS12075	COG2813	Specifically methylates the guanine in position
KS4_RS12090	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KS4_RS12095	COG1396	sequence-specific DNA binding
KS4_RS12100	COG1063	alcohol dehydrogenase
KS4_RS12105	COG0156	8-amino-7-oxononanoate synthase activity
KS4_RS12115	COG0538	isocitrate dehydrogenase activity
KS4_RS12120	COG2259	Doxx family
KS4_RS12135	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
KS4_RS12145	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KS4_RS12150	COG1196	nuclear chromosome segregation
KS4_RS12170	COG1442	glycosyl transferase family 8
KS4_RS12175	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
KS4_RS12180	COG0758	DNA mediated transformation
KS4_RS12205	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
KS4_RS12225	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
KS4_RS12250	COG0463	Glycosyl transferase, family 2
KS4_RS12280	COG0352	thiamine-phosphate diphosphorylase activity
KS4_RS12300	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
KS4_RS12310	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KS4_RS12325	COG3206	protein involved in exopolysaccharide biosynthesis
KS4_RS12325	COG0489	protein tyrosine kinase activity
KS4_RS12340	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
KS4_RS12350	COG0463	Glycosyl transferase, family 2
KS4_RS12375	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
KS4_RS12430	COG2188	Transcriptional regulator
KS4_RS12440	COG2207	Transcriptional regulator
KS4_RS12445	COG1595	DNA-templated transcription, initiation
KS4_RS12475	COG5652	VanZ like family
KS4_RS12490	COG2723	6-phospho-beta-galactosidase activity
KS4_RS12495	COG1609	Transcriptional regulator
KS4_RS12550	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KS4_RS12555	COG1450	Type ii and iii secretion system protein
KS4_RS12575	COG0516	GMP reductase activity
KS4_RS12575	COG0517	IMP dehydrogenase activity
KS4_RS12600	COG0594	ribonuclease P activity
KS4_RS12640	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
KS4_RS12640	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KS4_RS12665	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KS4_RS12670	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KS4_RS12680	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
KS4_RS12685	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KS4_RS12695	COG2022	thiamine diphosphate biosynthetic process
KS4_RS12725	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KS4_RS12760	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KS4_RS12760	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KS4_RS12785	COG2201	protein-glutamate methylesterase activity
KS4_RS12815	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
KS4_RS12820	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
KS4_RS12825	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KS4_RS12835	COG0174	glutamine synthetase
KS4_RS12840	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KS4_RS12855	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KS4_RS12855	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KS4_RS12870	COG0220	tRNA (guanine-N7-)-methyltransferase activity
KS4_RS12870	COG1519	Transferase
KS4_RS12875	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
KS4_RS12900	COG0848	biopolymer transport protein
KS4_RS12915	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
KS4_RS12920	COG0518	GMP synthase (glutamine-hydrolyzing) activity
KS4_RS12920	COG0519	Catalyzes the synthesis of GMP from XMP
KS4_RS12940	COG0783	Belongs to the Dps family
KS4_RS12945	COG0492	ferredoxin-NADP+ reductase activity
KS4_RS12980	COG2731	YhcH YjgK YiaL family protein
KS4_RS12985	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KS4_RS13015	COG0444	Belongs to the ABC transporter superfamily
KS4_RS13020	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KS4_RS13025	COG0601	transmembrane transport
KS4_RS13035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KS4_RS13045	COG1393	Belongs to the ArsC family
KS4_RS13050	COG2985	domain, Protein
KS4_RS13050	COG0490	domain, Protein
KS4_RS13065	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KS4_RS13075	COG4589	Belongs to the CDS family
KS4_RS13080	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
KS4_RS13095	COG0671	phosphoesterase, PA-phosphatase related
KS4_RS13105	COG3437	response regulator, receiver
KS4_RS13120	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
KS4_RS13125	COG2226	methyltransferase
KS4_RS13140	COG0321	lipoyl(octanoyl) transferase activity
KS4_RS13145	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KS4_RS13155	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
KS4_RS13160	COG1595	DNA-templated transcription, initiation
KS4_RS13170	COG0658	competence protein
KS4_RS13170	COG2333	competence protein COMEC
KS4_RS13180	COG0515	serine threonine protein kinase
KS4_RS13180	COG2815	serine threonine protein kinase
KS4_RS13195	COG0442	prolyl-tRNA aminoacylation
KS4_RS13210	COG0617	tRNA 3'-terminal CCA addition
KS4_RS13215	COG0586	Pfam SNARE associated Golgi protein
KS4_RS13220	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
KS4_RS13235	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
KS4_RS13240	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
KS4_RS13245	COG0314	molybdopterin synthase activity
KS4_RS13255	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
KS4_RS13265	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KS4_RS13270	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
KS4_RS13275	COG0071	Belongs to the small heat shock protein (HSP20) family
KS4_RS13280	COG0561	phosphatase activity
KS4_RS13305	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
KS4_RS13310	COG1073	alpha beta
KS4_RS13315	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KS4_RS13325	COG0667	Aldo Keto reductase
KS4_RS13360	COG0113	porphobilinogen synthase activity
KS4_RS13375	COG4566	intracellular signal transduction
KS4_RS13380	COG4191	Histidine kinase
KS4_RS13390	COG0742	ribosomal rna small subunit methyltransferase
KS4_RS13405	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KS4_RS13410	COG1862	Preprotein translocase
KS4_RS13415	COG0343	queuine tRNA-ribosyltransferase activity
KS4_RS13430	COG0745	RESPONSE REGULATOR receiver
KS4_RS13435	COG5002	protein histidine kinase activity
KS4_RS13455	COG1183	phosphatidylcholine synthase activity
KS4_RS13460	COG0667	Aldo Keto reductase
KS4_RS13465	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
KS4_RS13470	COG0494	nUDIX hydrolase
KS4_RS13485	COG1418	mRNA catabolic process
KS4_RS13500	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
KS4_RS13505	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
KS4_RS13520	COG0151	Belongs to the GarS family
KS4_RS13545	COG0584	glycerophosphoryl diester phosphodiesterase
KS4_RS13550	COG0584	glycerophosphoryl diester phosphodiesterase
KS4_RS13555	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
KS4_RS13560	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
KS4_RS13565	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
KS4_RS13590	COG3706	GGDEF domain
KS4_RS13600	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KS4_RS13610	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
KS4_RS13615	COG1215	transferase activity, transferring glycosyl groups
KS4_RS13625	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KS4_RS13640	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
KS4_RS13645	COG0459	protein refolding
KS4_RS13700	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KS4_RS13755	COG1181	Belongs to the D-alanine--D-alanine ligase family
KS4_RS13775	COG0148	phosphopyruvate hydratase activity
KS4_RS13810	COG0698	ribose 5-phosphate isomerase
KS4_RS13815	COG0039	L-malate dehydrogenase activity
KS4_RS13855	COG0261	This protein binds to 23S rRNA in the presence of protein L20
KS4_RS13890	COG0811	peptide transport
KS4_RS13930	COG0552	protein localization to endoplasmic reticulum
KS4_RS13950	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
KS4_RS13970	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
KS4_RS13990	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
KS4_RS14005	COG0740	serine-type endopeptidase activity
KS4_RS14015	COG1054	Belongs to the UPF0176 family
KS4_RS14070	COG3842	ATPase activity
KS4_RS14075	COG0395	ABC-type sugar transport system, permease component
KS4_RS14080	COG1175	transmembrane transport
KS4_RS14090	COG1609	Transcriptional regulator
KS4_RS14110	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KS4_RS14115	COG0508	dehydrogenase complex catalyzes the overall conversion of
KS4_RS14120	COG0567	Dehydrogenase, E1 component
KS4_RS14125	COG0730	response to heat
KS4_RS14130	COG0501	Belongs to the peptidase M48B family
KS4_RS14145	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
KS4_RS14155	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KS4_RS14180	COG0107	imidazoleglycerol-phosphate synthase activity
KS4_RS14215	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KS4_RS14225	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KS4_RS14230	COG0471	metal ion transport
KS4_RS14230	COG3273	potassium ion transport
KS4_RS14255	COG1459	type II secretion system
KS4_RS14270	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
KS4_RS14290	COG0489	protein tyrosine kinase activity
KS4_RS14295	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KS4_RS14300	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KS4_RS14310	COG2258	MOSC domain
KS4_RS14315	COG0052	Belongs to the universal ribosomal protein uS2 family
KS4_RS14320	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
KS4_RS14345	COG0585	pseudouridine synthase activity
KS4_RS14350	COG2226	methyltransferase
KS4_RS14365	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
KS4_RS14385	COG0659	secondary active sulfate transmembrane transporter activity
KS4_RS14400	COG0423	glycine-tRNA ligase activity
KS4_RS14415	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
KS4_RS14415	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
KS4_RS14425	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KS4_RS14430	COG0728	peptidoglycan biosynthetic process
KS4_RS14435	COG0702	epimerase
KS4_RS14445	COG0740	serine-type endopeptidase activity
KS4_RS14455	COG4537	Required for transformation and DNA binding
KS4_RS14465	COG1609	Transcriptional regulator
KS4_RS14490	COG0842	Transport permease protein
KS4_RS14515	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KS4_RS14545	COG0019	diaminopimelate decarboxylase activity
KS4_RS14550	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KS4_RS14560	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
KS4_RS14565	COG4221	oxidoreductase activity
KS4_RS14600	COG1595	DNA-templated transcription, initiation
KS4_RS14620	COG1024	Enoyl-CoA hydratase
KS4_RS14645	COG3842	ATPase activity
KS4_RS14650	COG0686	Belongs to the AlaDH PNT family
KS4_RS14665	COG1012	belongs to the aldehyde dehydrogenase family
KS4_RS14695	COG1845	cytochrome c oxidase, subunit III
KS4_RS14710	COG1845	cytochrome c oxidase, subunit III
KS4_RS14710	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KS4_RS14750	COG0437	4 iron, 4 sulfur cluster binding
KS4_RS14765	COG0792	nuclease activity
KS4_RS14780	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
KS4_RS14790	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
KS4_RS14805	COG0443	Heat shock 70 kDa protein
KS4_RS14825	COG2252	PERMEase
KS4_RS14845	COG0084	hydrolase, TatD family'
KS4_RS14875	COG0367	asparagine synthase
KS4_RS14890	COG5002	protein histidine kinase activity
KS4_RS14895	COG0165	Argininosuccinate lyase
KS4_RS14900	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KS4_RS14915	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KS4_RS14920	COG1028	Short-chain dehydrogenase reductase Sdr
KS4_RS14935	COG2154	pterin-4-alpha-carbinolamine dehydratase
KS4_RS14960	COG1538	Outer membrane efflux protein
KS4_RS14970	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KS4_RS14980	COG2715	membrane protein required for spore maturation
KS4_RS14985	COG0700	Nucleoside recognition
KS4_RS14995	COG1088	dTDP-glucose 4,6-dehydratase activity
KS4_RS15000	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
KS4_RS15030	COG0632	four-way junction helicase activity
KS4_RS15040	COG1846	Transcriptional regulator
KS4_RS15045	COG0667	Aldo Keto reductase
KS4_RS15050	COG0756	dUTP diphosphatase activity
KS4_RS15055	COG0561	phosphatase activity
KS4_RS15060	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KS4_RS15070	COG0572	uridine kinase
KS4_RS15080	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KS4_RS15090	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KS4_RS15095	COG0604	alcohol dehydrogenase
KS4_RS15100	COG0138	bifunctional purine biosynthesis protein purh
KS4_RS15105	COG1674	ftsk spoiiie
KS4_RS15145	COG0137	argininosuccinate synthase activity
KS4_RS15175	COG0745	RESPONSE REGULATOR receiver
KS4_RS15185	COG4260	virion core protein, lumpy skin disease virus
KS4_RS15190	COG1639	'signal transduction protein
KS4_RS15210	COG0668	transmembrane transport
KS4_RS15235	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KS4_RS15265	COG0492	ferredoxin-NADP+ reductase activity
KS4_RS15285	COG1301	dicarboxylic acid transport
KS4_RS15295	COG0181	hydroxymethylbilane synthase activity
KS4_RS15340	COG0149	triose-phosphate isomerase activity
KS4_RS15350	COG1561	YicC-like family, N-terminal region
KS4_RS15375	COG1070	Carbohydrate kinase
KS4_RS15380	COG0693	protein deglycase activity
KS4_RS15390	COG1011	Hydrolase
KS4_RS15395	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
KS4_RS15400	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KS4_RS15410	COG0187	DNA topoisomerase II activity
KS4_RS15420	COG0745	RESPONSE REGULATOR receiver
KS4_RS15425	COG5002	protein histidine kinase activity
KS4_RS15435	COG1450	Type ii and iii secretion system protein
KS4_RS15470	COG0481	GTPase activity
KS4_RS15480	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
KS4_RS15490	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
KS4_RS15525	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
KS4_RS15530	COG0667	Aldo Keto reductase
KS4_RS15555	COG0126	phosphoglycerate kinase activity
KS4_RS15565	COG0840	transmembrane signaling receptor activity
KS4_RS15585	COG1733	regulation of RNA biosynthetic process
KS4_RS15590	COG1902	pentaerythritol trinitrate reductase activity
KS4_RS15605	COG1649	PFAM Uncharacterised BCR, COG1649
KS4_RS15610	COG2385	sporulation resulting in formation of a cellular spore
KS4_RS15680	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
KS4_RS15690	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KS4_RS15690	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
KS4_RS15700	COG1609	Transcriptional regulator
KS4_RS15705	COG1297	OPT oligopeptide transporter protein
KS4_RS15720	COG1609	Transcriptional regulator
KS4_RS15740	COG0525	valine-tRNA ligase activity
KS4_RS15745	COG1335	isochorismatase
KS4_RS15765	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
KS4_RS15770	COG0742	ribosomal rna small subunit methyltransferase
KS4_RS15780	COG4968	Prepilin-type N-terminal cleavage methylation domain
KS4_RS15805	COG4221	oxidoreductase activity
KS4_RS15830	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
KS4_RS15840	COG2208	phosphoserine phosphatase activity
KS4_RS15845	COG0205	6-phosphofructokinase activity
KS4_RS15870	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
KS4_RS15875	COG0676	glucose-6-phosphate 1-epimerase activity
KS4_RS15890	COG1131	(ABC) transporter
KS4_RS15915	COG0745	RESPONSE REGULATOR receiver
KS4_RS15920	COG3852	Histidine kinase
KS4_RS15925	COG0745	RESPONSE REGULATOR receiver
KS4_RS15935	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
KS4_RS15940	COG0778	Nitroreductase
KS4_RS15960	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
KS4_RS15965	COG1543	Belongs to the glycosyl hydrolase 57 family
KS4_RS15975	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
KS4_RS16000	COG0318	PFAM AMP-dependent synthetase and ligase
KS4_RS16050	COG0300	oxidoreductase activity
KS4_RS16070	COG3228	Belongs to the MtfA family
KS4_RS16080	COG1414	Transcriptional regulator
KS4_RS16085	COG3119	arylsulfatase activity
KS4_RS16090	COG2814	Major facilitator Superfamily
KS4_RS16095	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
KS4_RS16100	COG2204	response regulator
KS4_RS16115	COG0009	L-threonylcarbamoyladenylate synthase
KS4_RS16130	COG1381	Involved in DNA repair and RecF pathway recombination
KS4_RS16140	COG0563	adenylate kinase activity
KS4_RS16150	COG1959	2 iron, 2 sulfur cluster binding
KS4_RS16155	COG1104	cysteine desulfurase activity
KS4_RS16160	COG0822	iron-sulfur transferase activity
KS4_RS16165	COG0316	Belongs to the HesB IscA family
KS4_RS16170	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
KS4_RS16180	COG1830	Aldolase
KS4_RS16185	COG0406	alpha-ribazole phosphatase activity
KS4_RS16205	COG2001	Belongs to the MraZ family
KS4_RS16215	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
KS4_RS16220	COG0557	exoribonuclease II activity
KS4_RS16240	COG0427	acetyl-CoA hydrolase
KS4_RS16255	COG0511	ligase activity, forming carbon-carbon bonds
KS4_RS16270	COG0346	lactoylglutathione lyase activity
KS4_RS16275	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KS4_RS16275	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KS4_RS16280	COG1703	isobutyryl-CoA mutase activity
KS4_RS16285	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KS4_RS16285	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KS4_RS16315	COG0534	Mate efflux family protein
KS4_RS16390	COG1796	DNA polymerase
KS4_RS16390	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
KS4_RS16395	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KS4_RS16395	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KS4_RS16415	COG1054	Belongs to the UPF0176 family
KS4_RS16435	COG1192	Involved in chromosome partitioning
KS4_RS16440	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
KS4_RS16450	COG3961	Belongs to the TPP enzyme family
KS4_RS16455	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KS4_RS16465	COG3119	arylsulfatase activity
KS4_RS16475	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
KS4_RS16480	COG1083	cytidylyl-transferase
KS4_RS16480	COG2755	lipolytic protein G-D-S-L family
KS4_RS16545	COG4974	Belongs to the 'phage' integrase family
KS4_RS16570	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KS4_RS16580	COG3724	N-succinylarginine dihydrolase activity
KS4_RS16620	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
KS4_RS16625	COG1262	PFAM Formylglycine-generating sulfatase enzyme
KS4_RS16650	COG3958	Transketolase
KS4_RS16660	COG0840	transmembrane signaling receptor activity
KS4_RS16665	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
KS4_RS16670	COG0110	maltose O-acetyltransferase activity
KS4_RS16675	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KS4_RS16675	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KS4_RS16685	COG0300	oxidoreductase activity
KS4_RS16755	COG1217	gtp-binding protein TYPA
KS4_RS16760	COG1366	Belongs to the anti-sigma-factor antagonist family
KS4_RS16790	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
KS4_RS16810	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
KS4_RS16815	COG3250	beta-galactosidase activity
KS4_RS16820	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
KS4_RS16840	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KS4_RS16845	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KS4_RS16905	COG0835	chemotaxis
KS4_RS16915	COG2198	Histidine kinase
KS4_RS16915	COG0784	Response regulator, receiver
KS4_RS16915	COG0643	Histidine kinase
KS4_RS16920	COG1406	Chemotaxis phosphatase CheX
KS4_RS16925	COG0745	RESPONSE REGULATOR receiver
KS4_RS16935	COG2201	protein-glutamate methylesterase activity
KS4_RS16960	COG2995	paraquat-inducible protein a
KS4_RS16965	COG3527	Alpha-acetolactate decarboxylase
KS4_RS16990	COG2015	COG2015, Alkyl sulfatase and related hydrolases
KS4_RS17025	COG1874	Beta-galactosidase
KS4_RS17025	COG0366	Alpha amylase catalytic
KS4_RS17030	COG4166	transmembrane transport
KS4_RS17040	COG0438	transferase activity, transferring glycosyl groups
KS4_RS17045	COG4166	transmembrane transport
KS4_RS17055	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KS4_RS17065	COG0601	transmembrane transport
KS4_RS17100	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
KS4_RS17130	COG0011	TIGRFAM Protein of
KS4_RS17145	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
KS4_RS17170	COG0542	response to heat
KS4_RS17190	COG1192	Involved in chromosome partitioning
KS4_RS17200	COG1663	tetraacyldisaccharide 4'-kinase activity
KS4_RS17205	COG3920	Histidine kinase
KS4_RS17215	COG0473	3-isopropylmalate dehydrogenase activity
KS4_RS17265	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
KS4_RS17270	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
KS4_RS17275	COG1692	metallophosphoesterase
KS4_RS17285	COG2199	diguanylate cyclase activity
KS4_RS17285	COG2203	Gaf domain
KS4_RS17300	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KS4_RS17325	COG4651	solute:proton antiporter activity
KS4_RS17325	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KS4_RS17335	COG2329	Antibiotic biosynthesis monooxygenase
KS4_RS17345	COG0730	response to heat
KS4_RS17375	COG3177	Filamentation induced by cAMP protein fic
KS4_RS17395	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain